-- dump date 20140618_210558 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1283330000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1283330000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1283330000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330000004 Walker A motif; other site 1283330000005 ATP binding site [chemical binding]; other site 1283330000006 Walker B motif; other site 1283330000007 arginine finger; other site 1283330000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1283330000009 DnaA box-binding interface [nucleotide binding]; other site 1283330000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1283330000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1283330000012 putative DNA binding surface [nucleotide binding]; other site 1283330000013 dimer interface [polypeptide binding]; other site 1283330000014 beta-clamp/clamp loader binding surface; other site 1283330000015 beta-clamp/translesion DNA polymerase binding surface; other site 1283330000016 recombination protein F; Reviewed; Region: recF; PRK00064 1283330000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330000018 Walker A/P-loop; other site 1283330000019 ATP binding site [chemical binding]; other site 1283330000020 Q-loop/lid; other site 1283330000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330000022 ABC transporter signature motif; other site 1283330000023 Walker B; other site 1283330000024 D-loop; other site 1283330000025 H-loop/switch region; other site 1283330000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1283330000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330000028 Mg2+ binding site [ion binding]; other site 1283330000029 G-X-G motif; other site 1283330000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1283330000031 anchoring element; other site 1283330000032 dimer interface [polypeptide binding]; other site 1283330000033 ATP binding site [chemical binding]; other site 1283330000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1283330000035 active site 1283330000036 putative metal-binding site [ion binding]; other site 1283330000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1283330000038 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1283330000039 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 1283330000040 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1283330000041 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1283330000042 putative acyl-acceptor binding pocket; other site 1283330000043 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1283330000044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330000045 active site 1283330000046 motif I; other site 1283330000047 motif II; other site 1283330000048 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1283330000049 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1283330000050 dimer interface [polypeptide binding]; other site 1283330000051 motif 1; other site 1283330000052 active site 1283330000053 motif 2; other site 1283330000054 motif 3; other site 1283330000055 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1283330000056 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1283330000057 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1283330000058 putative active site [active] 1283330000059 putative metal binding site [ion binding]; other site 1283330000060 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1283330000061 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1283330000062 TrkA-N domain; Region: TrkA_N; pfam02254 1283330000063 TrkA-C domain; Region: TrkA_C; pfam02080 1283330000064 TrkA-N domain; Region: TrkA_N; pfam02254 1283330000065 TrkA-C domain; Region: TrkA_C; pfam02080 1283330000066 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1283330000067 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1283330000068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330000069 S-adenosylmethionine binding site [chemical binding]; other site 1283330000070 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1283330000071 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1283330000072 putative active site [active] 1283330000073 substrate binding site [chemical binding]; other site 1283330000074 putative cosubstrate binding site; other site 1283330000075 catalytic site [active] 1283330000076 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1283330000077 substrate binding site [chemical binding]; other site 1283330000078 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1283330000079 active site 1283330000080 catalytic residues [active] 1283330000081 metal binding site [ion binding]; metal-binding site 1283330000082 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1283330000083 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1283330000084 DNA protecting protein DprA; Region: dprA; TIGR00732 1283330000085 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1283330000086 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1283330000087 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1283330000088 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1283330000089 NADP binding site [chemical binding]; other site 1283330000090 dimer interface [polypeptide binding]; other site 1283330000091 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1283330000092 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1283330000093 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1283330000094 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1283330000095 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1283330000096 shikimate binding site; other site 1283330000097 NAD(P) binding site [chemical binding]; other site 1283330000098 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1283330000099 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1283330000100 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1283330000101 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1283330000102 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1283330000103 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1283330000104 MgtC family; Region: MgtC; pfam02308 1283330000105 Hemerythrin-like domain; Region: Hr-like; cd12108 1283330000106 Fe binding site [ion binding]; other site 1283330000107 Protein of unknown function (DUF3182); Region: DUF3182; pfam11379 1283330000108 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1283330000109 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1283330000110 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283330000111 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1283330000112 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 1283330000113 Cytochrome c; Region: Cytochrom_C; cl11414 1283330000114 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330000115 metal binding site [ion binding]; metal-binding site 1283330000116 active site 1283330000117 I-site; other site 1283330000118 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1283330000119 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1283330000120 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1283330000121 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1283330000122 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1283330000123 dimerization interface [polypeptide binding]; other site 1283330000124 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1283330000125 heme-binding site [chemical binding]; other site 1283330000126 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330000127 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330000128 metal binding site [ion binding]; metal-binding site 1283330000129 active site 1283330000130 I-site; other site 1283330000131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4395 1283330000132 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1283330000133 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1283330000134 putative ligand binding residues [chemical binding]; other site 1283330000135 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1283330000136 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283330000137 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1283330000138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1283330000139 Walker A/P-loop; other site 1283330000140 ATP binding site [chemical binding]; other site 1283330000141 Q-loop/lid; other site 1283330000142 ABC transporter signature motif; other site 1283330000143 Walker B; other site 1283330000144 D-loop; other site 1283330000145 H-loop/switch region; other site 1283330000146 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1283330000147 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1283330000148 ligand-binding site [chemical binding]; other site 1283330000149 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1283330000150 Part of AAA domain; Region: AAA_19; pfam13245 1283330000151 Family description; Region: UvrD_C_2; pfam13538 1283330000152 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330000153 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330000154 metal binding site [ion binding]; metal-binding site 1283330000155 active site 1283330000156 I-site; other site 1283330000157 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283330000158 putative protease; Provisional; Region: PRK15452 1283330000159 Peptidase family U32; Region: Peptidase_U32; pfam01136 1283330000160 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1283330000161 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1283330000162 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1283330000163 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1283330000164 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1283330000165 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1283330000166 Walker A/P-loop; other site 1283330000167 ATP binding site [chemical binding]; other site 1283330000168 Q-loop/lid; other site 1283330000169 ABC transporter signature motif; other site 1283330000170 Walker B; other site 1283330000171 D-loop; other site 1283330000172 H-loop/switch region; other site 1283330000173 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1283330000174 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1283330000175 Walker A/P-loop; other site 1283330000176 ATP binding site [chemical binding]; other site 1283330000177 Q-loop/lid; other site 1283330000178 ABC transporter signature motif; other site 1283330000179 Walker B; other site 1283330000180 D-loop; other site 1283330000181 H-loop/switch region; other site 1283330000182 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1283330000183 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283330000184 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283330000185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283330000186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283330000187 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1283330000188 DNA polymerase I; Provisional; Region: PRK05755 1283330000189 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1283330000190 active site 1283330000191 metal binding site 1 [ion binding]; metal-binding site 1283330000192 putative 5' ssDNA interaction site; other site 1283330000193 metal binding site 3; metal-binding site 1283330000194 metal binding site 2 [ion binding]; metal-binding site 1283330000195 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1283330000196 putative DNA binding site [nucleotide binding]; other site 1283330000197 putative metal binding site [ion binding]; other site 1283330000198 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1283330000199 active site 1283330000200 catalytic site [active] 1283330000201 substrate binding site [chemical binding]; other site 1283330000202 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1283330000203 active site 1283330000204 DNA binding site [nucleotide binding] 1283330000205 catalytic site [active] 1283330000206 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1283330000207 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1283330000208 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1283330000209 putative active site [active] 1283330000210 putative substrate binding site [chemical binding]; other site 1283330000211 ATP binding site [chemical binding]; other site 1283330000212 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1283330000213 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1283330000214 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 1283330000215 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1283330000216 active site 1283330000217 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1283330000218 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330000219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330000220 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1283330000221 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1283330000222 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1283330000223 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1283330000224 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1283330000225 Probable transposase; Region: OrfB_IS605; pfam01385 1283330000226 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1283330000227 Membrane bound O-acyl transferase family; Region: MBOAT_2; pfam13813 1283330000228 Isochorismatase family; Region: Isochorismatase; pfam00857 1283330000229 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1283330000230 catalytic triad [active] 1283330000231 conserved cis-peptide bond; other site 1283330000232 TSCPD domain; Region: TSCPD; pfam12637 1283330000233 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1283330000234 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1283330000235 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1283330000236 active site 1283330000237 dimer interface [polypeptide binding]; other site 1283330000238 effector binding site; other site 1283330000239 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1283330000240 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1283330000241 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1283330000242 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 1283330000243 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1283330000244 metal binding site [ion binding]; metal-binding site 1283330000245 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1283330000246 metal binding site 2 [ion binding]; metal-binding site 1283330000247 putative DNA binding helix; other site 1283330000248 metal binding site 1 [ion binding]; metal-binding site 1283330000249 dimer interface [polypeptide binding]; other site 1283330000250 structural Zn2+ binding site [ion binding]; other site 1283330000251 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1283330000252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330000253 Walker A/P-loop; other site 1283330000254 ATP binding site [chemical binding]; other site 1283330000255 Q-loop/lid; other site 1283330000256 ABC transporter signature motif; other site 1283330000257 Walker B; other site 1283330000258 D-loop; other site 1283330000259 H-loop/switch region; other site 1283330000260 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1283330000261 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1283330000262 dimer interface [polypeptide binding]; other site 1283330000263 putative PBP binding regions; other site 1283330000264 ABC-ATPase subunit interface; other site 1283330000265 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1283330000266 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1283330000267 putative NAD(P) binding site [chemical binding]; other site 1283330000268 putative substrate binding site [chemical binding]; other site 1283330000269 catalytic Zn binding site [ion binding]; other site 1283330000270 structural Zn binding site [ion binding]; other site 1283330000271 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1283330000272 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1283330000273 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1283330000274 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1283330000275 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1283330000276 Cytochrome c; Region: Cytochrom_C; pfam00034 1283330000277 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330000278 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1283330000279 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1283330000280 Cu(I) binding site [ion binding]; other site 1283330000281 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1283330000282 UbiA prenyltransferase family; Region: UbiA; pfam01040 1283330000283 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1283330000284 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1283330000285 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1283330000286 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 1283330000287 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1283330000288 Subunit III/VIIa interface [polypeptide binding]; other site 1283330000289 Phospholipid binding site [chemical binding]; other site 1283330000290 Subunit I/III interface [polypeptide binding]; other site 1283330000291 Subunit III/VIb interface [polypeptide binding]; other site 1283330000292 Subunit III/VIa interface; other site 1283330000293 Subunit III/Vb interface [polypeptide binding]; other site 1283330000294 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 1283330000295 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 1283330000296 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1283330000297 Subunit I/III interface [polypeptide binding]; other site 1283330000298 D-pathway; other site 1283330000299 Subunit I/VIIc interface [polypeptide binding]; other site 1283330000300 Subunit I/IV interface [polypeptide binding]; other site 1283330000301 Subunit I/II interface [polypeptide binding]; other site 1283330000302 Low-spin heme (heme a) binding site [chemical binding]; other site 1283330000303 Subunit I/VIIa interface [polypeptide binding]; other site 1283330000304 Subunit I/VIa interface [polypeptide binding]; other site 1283330000305 Dimer interface; other site 1283330000306 Putative water exit pathway; other site 1283330000307 Binuclear center (heme a3/CuB) [ion binding]; other site 1283330000308 K-pathway; other site 1283330000309 Subunit I/Vb interface [polypeptide binding]; other site 1283330000310 Putative proton exit pathway; other site 1283330000311 Subunit I/VIb interface; other site 1283330000312 Subunit I/VIc interface [polypeptide binding]; other site 1283330000313 Electron transfer pathway; other site 1283330000314 Subunit I/VIIIb interface [polypeptide binding]; other site 1283330000315 Subunit I/VIIb interface [polypeptide binding]; other site 1283330000316 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1283330000317 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1283330000318 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1283330000319 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1283330000320 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1283330000321 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1283330000322 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1283330000323 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1283330000324 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1283330000325 active site clefts [active] 1283330000326 zinc binding site [ion binding]; other site 1283330000327 dimer interface [polypeptide binding]; other site 1283330000328 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 1283330000329 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1283330000330 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1283330000331 active site 1283330000332 Zn binding site [ion binding]; other site 1283330000333 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1283330000334 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330000335 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330000336 DNA binding residues [nucleotide binding] 1283330000337 fec operon regulator FecR; Reviewed; Region: PRK09774 1283330000338 FecR protein; Region: FecR; pfam04773 1283330000339 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283330000340 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283330000341 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330000342 N-terminal plug; other site 1283330000343 ligand-binding site [chemical binding]; other site 1283330000344 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1283330000345 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1283330000346 trimer interface [polypeptide binding]; other site 1283330000347 putative metal binding site [ion binding]; other site 1283330000348 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1283330000349 Predicted aminopeptidase (DUF2265); Region: DUF2265; pfam10023 1283330000350 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1283330000351 active site 1283330000352 homodimer interface [polypeptide binding]; other site 1283330000353 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1283330000354 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1283330000355 ATP-grasp domain; Region: ATP-grasp; pfam02222 1283330000356 Predicted membrane protein [Function unknown]; Region: COG2261 1283330000357 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1283330000358 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1283330000359 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1283330000360 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330000361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330000362 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 1283330000363 Walker A/P-loop; other site 1283330000364 ATP binding site [chemical binding]; other site 1283330000365 Q-loop/lid; other site 1283330000366 ABC transporter signature motif; other site 1283330000367 Walker B; other site 1283330000368 D-loop; other site 1283330000369 H-loop/switch region; other site 1283330000370 TOBE domain; Region: TOBE; cl01440 1283330000371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330000372 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1283330000373 dimer interface [polypeptide binding]; other site 1283330000374 conserved gate region; other site 1283330000375 putative PBP binding loops; other site 1283330000376 ABC-ATPase subunit interface; other site 1283330000377 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1283330000378 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1283330000379 Hemerythrin; Region: Hemerythrin; cd12107 1283330000380 Fe binding site [ion binding]; other site 1283330000381 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1283330000382 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 1283330000383 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1283330000384 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1283330000385 putative acyl-acceptor binding pocket; other site 1283330000386 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1283330000387 acyl-activating enzyme (AAE) consensus motif; other site 1283330000388 AMP binding site [chemical binding]; other site 1283330000389 active site 1283330000390 CoA binding site [chemical binding]; other site 1283330000391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330000392 non-specific DNA binding site [nucleotide binding]; other site 1283330000393 salt bridge; other site 1283330000394 sequence-specific DNA binding site [nucleotide binding]; other site 1283330000395 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1283330000396 nitrogenase iron protein; Region: nifH; TIGR01287 1283330000397 Nucleotide-binding sites [chemical binding]; other site 1283330000398 Walker A motif; other site 1283330000399 Switch I region of nucleotide binding site; other site 1283330000400 Fe4S4 binding sites [ion binding]; other site 1283330000401 Switch II region of nucleotide binding site; other site 1283330000402 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 1283330000403 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 1283330000404 MoFe protein alpha/beta subunit interactions; other site 1283330000405 Alpha subunit P cluster binding residues; other site 1283330000406 FeMoco binding residues [chemical binding]; other site 1283330000407 MoFe protein alpha subunit/Fe protein contacts; other site 1283330000408 MoFe protein dimer/ dimer interactions; other site 1283330000409 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 1283330000410 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 1283330000411 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 1283330000412 MoFe protein beta/alpha subunit interactions; other site 1283330000413 Beta subunit P cluster binding residues; other site 1283330000414 MoFe protein beta subunit/Fe protein contacts; other site 1283330000415 MoFe protein dimer/ dimer interactions; other site 1283330000416 NifT/FixU protein; Region: NifT; pfam06988 1283330000417 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1283330000418 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 1283330000419 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1283330000420 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 1283330000421 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 1283330000422 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1283330000423 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1283330000424 probable nitrogen fixation protein; Region: TIGR02935 1283330000425 Rop-like; Region: Rop-like; pfam05082 1283330000426 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 1283330000427 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1283330000428 dimer interface [polypeptide binding]; other site 1283330000429 [2Fe-2S] cluster binding site [ion binding]; other site 1283330000430 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 1283330000431 Domain of unknown function (DUF364); Region: DUF364; pfam04016 1283330000432 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 1283330000433 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 1283330000434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330000435 Walker A/P-loop; other site 1283330000436 ATP binding site [chemical binding]; other site 1283330000437 Q-loop/lid; other site 1283330000438 ABC transporter signature motif; other site 1283330000439 Walker B; other site 1283330000440 D-loop; other site 1283330000441 H-loop/switch region; other site 1283330000442 TOBE domain; Region: TOBE; pfam03459 1283330000443 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1283330000444 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 1283330000445 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1283330000446 trimerization site [polypeptide binding]; other site 1283330000447 active site 1283330000448 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1283330000449 NifU-like domain; Region: NifU; pfam01106 1283330000450 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1283330000451 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1283330000452 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283330000453 catalytic residue [active] 1283330000454 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 1283330000455 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 1283330000456 active site 1283330000457 catalytic residues [active] 1283330000458 metal binding site [ion binding]; metal-binding site 1283330000459 serine O-acetyltransferase; Region: cysE; TIGR01172 1283330000460 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1283330000461 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1283330000462 trimer interface [polypeptide binding]; other site 1283330000463 active site 1283330000464 substrate binding site [chemical binding]; other site 1283330000465 CoA binding site [chemical binding]; other site 1283330000466 Nitrogen fixation protein NifW; Region: NifW; pfam03206 1283330000467 NifZ domain; Region: NifZ; pfam04319 1283330000468 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 1283330000469 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1283330000470 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1283330000471 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 1283330000472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330000473 Walker A motif; other site 1283330000474 ATP binding site [chemical binding]; other site 1283330000475 Walker B motif; other site 1283330000476 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1283330000477 flavodoxin FldA; Validated; Region: PRK09267 1283330000478 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1283330000479 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1283330000480 Protein of unknown function (DUF3301); Region: DUF3301; pfam11743 1283330000481 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1283330000482 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 1283330000483 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1283330000484 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1283330000485 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1283330000486 Membrane transport protein; Region: Mem_trans; cl09117 1283330000487 Membrane transport protein; Region: Mem_trans; cl09117 1283330000488 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1283330000489 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 1283330000490 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1283330000491 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1283330000492 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1283330000493 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1283330000494 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1283330000495 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1283330000496 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1283330000497 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1283330000498 ligand binding site [chemical binding]; other site 1283330000499 homodimer interface [polypeptide binding]; other site 1283330000500 NAD(P) binding site [chemical binding]; other site 1283330000501 trimer interface B [polypeptide binding]; other site 1283330000502 trimer interface A [polypeptide binding]; other site 1283330000503 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1283330000504 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283330000505 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1283330000506 Protein export membrane protein; Region: SecD_SecF; cl14618 1283330000507 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 1283330000508 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1283330000509 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1283330000510 Predicted transporter component [General function prediction only]; Region: COG2391 1283330000511 Sulphur transport; Region: Sulf_transp; pfam04143 1283330000512 Predicted transporter component [General function prediction only]; Region: COG2391 1283330000513 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1283330000514 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1283330000515 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1283330000516 amidase catalytic site [active] 1283330000517 Zn binding residues [ion binding]; other site 1283330000518 substrate binding site [chemical binding]; other site 1283330000519 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1283330000520 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1283330000521 putative catalytic site [active] 1283330000522 putative metal binding site [ion binding]; other site 1283330000523 putative phosphate binding site [ion binding]; other site 1283330000524 putative catalytic site [active] 1283330000525 putative phosphate binding site [ion binding]; other site 1283330000526 putative metal binding site [ion binding]; other site 1283330000527 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1283330000528 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1283330000529 catalytic residues [active] 1283330000530 hinge region; other site 1283330000531 alpha helical domain; other site 1283330000532 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1283330000533 Cytochrome c; Region: Cytochrom_C; cl11414 1283330000534 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1283330000535 G1 box; other site 1283330000536 GTP/Mg2+ binding site [chemical binding]; other site 1283330000537 Switch I region; other site 1283330000538 G2 box; other site 1283330000539 G3 box; other site 1283330000540 Switch II region; other site 1283330000541 G4 box; other site 1283330000542 G5 box; other site 1283330000543 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1283330000544 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1283330000545 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1283330000546 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1283330000547 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1283330000548 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1283330000549 putative active site [active] 1283330000550 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330000551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330000552 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1283330000553 putative dimerization interface [polypeptide binding]; other site 1283330000554 pyruvate carboxylase subunit A; Validated; Region: PRK07178 1283330000555 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1283330000556 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1283330000557 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1283330000558 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1283330000559 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1283330000560 active site 1283330000561 catalytic residues [active] 1283330000562 metal binding site [ion binding]; metal-binding site 1283330000563 homodimer binding site [polypeptide binding]; other site 1283330000564 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1283330000565 carboxyltransferase (CT) interaction site; other site 1283330000566 biotinylation site [posttranslational modification]; other site 1283330000567 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1283330000568 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1283330000569 Dodecin; Region: Dodecin; pfam07311 1283330000570 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 1283330000571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330000572 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283330000573 dimerization interface [polypeptide binding]; other site 1283330000574 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1283330000575 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1283330000576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330000577 catalytic residue [active] 1283330000578 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1283330000579 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1283330000580 substrate binding site [chemical binding]; other site 1283330000581 active site 1283330000582 catalytic residues [active] 1283330000583 heterodimer interface [polypeptide binding]; other site 1283330000584 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1283330000585 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1283330000586 HSP70 interaction site [polypeptide binding]; other site 1283330000587 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1283330000588 substrate binding site [polypeptide binding]; other site 1283330000589 dimer interface [polypeptide binding]; other site 1283330000590 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1283330000591 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1283330000592 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1283330000593 Cupin domain; Region: Cupin_2; cl17218 1283330000594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330000595 Helix-turn-helix domain; Region: HTH_18; pfam12833 1283330000596 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283330000597 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283330000598 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330000599 N-terminal plug; other site 1283330000600 ligand-binding site [chemical binding]; other site 1283330000601 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283330000602 FecR protein; Region: FecR; pfam04773 1283330000603 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1283330000604 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330000605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330000606 DNA binding residues [nucleotide binding] 1283330000607 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1283330000608 active site 1283330000609 General stress protein [General function prediction only]; Region: GsiB; COG3729 1283330000610 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1283330000611 CsbD-like; Region: CsbD; pfam05532 1283330000612 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1283330000613 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1283330000614 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1283330000615 DNA binding residues [nucleotide binding] 1283330000616 putative dimer interface [polypeptide binding]; other site 1283330000617 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1283330000618 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1283330000619 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283330000620 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1283330000621 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1283330000622 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1283330000623 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1283330000624 putative FMN binding site [chemical binding]; other site 1283330000625 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283330000626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330000627 Walker A/P-loop; other site 1283330000628 ATP binding site [chemical binding]; other site 1283330000629 Q-loop/lid; other site 1283330000630 ABC transporter signature motif; other site 1283330000631 Walker B; other site 1283330000632 D-loop; other site 1283330000633 H-loop/switch region; other site 1283330000634 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283330000635 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1283330000636 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1283330000637 active site 1283330000638 catalytic residues [active] 1283330000639 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1283330000640 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1283330000641 active site 1283330000642 catalytic site [active] 1283330000643 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1283330000644 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1283330000645 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 1283330000646 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1283330000647 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1283330000648 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1283330000649 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1283330000650 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1283330000651 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1283330000652 active site 1283330000653 NTP binding site [chemical binding]; other site 1283330000654 metal binding triad [ion binding]; metal-binding site 1283330000655 antibiotic binding site [chemical binding]; other site 1283330000656 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 1283330000657 thymidylate kinase; Provisional; Region: PRK13975; cl17243 1283330000658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 1283330000659 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 1283330000660 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1283330000661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330000662 dimer interface [polypeptide binding]; other site 1283330000663 conserved gate region; other site 1283330000664 ABC-ATPase subunit interface; other site 1283330000665 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 1283330000666 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1283330000667 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1283330000668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330000669 Walker A/P-loop; other site 1283330000670 ATP binding site [chemical binding]; other site 1283330000671 Q-loop/lid; other site 1283330000672 ABC transporter signature motif; other site 1283330000673 Walker B; other site 1283330000674 D-loop; other site 1283330000675 H-loop/switch region; other site 1283330000676 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1283330000677 Nitrogenase_VFe_beta -like: Nitrogenase VFe protein, beta subunit like. This group contains proteins similar to the beta subunits of the VFe protein of the vanadium-dependent (V-) nitrogenase. Nitrogenase catalyzes the ATP-dependent reduction of...; Region: Nitrogenase_VFe_beta_like; cd01973 1283330000678 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1283330000679 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; pfam03139 1283330000680 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 1283330000681 Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of, the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977 1283330000682 hypothetical protein; Provisional; Region: PRK13795 1283330000683 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1283330000684 nitrogenase iron protein; Region: nifH; TIGR01287 1283330000685 Nucleotide-binding sites [chemical binding]; other site 1283330000686 Walker A motif; other site 1283330000687 Switch I region of nucleotide binding site; other site 1283330000688 Fe4S4 binding sites [ion binding]; other site 1283330000689 Switch II region of nucleotide binding site; other site 1283330000690 benzoate transport; Region: 2A0115; TIGR00895 1283330000691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330000692 putative substrate translocation pore; other site 1283330000693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330000694 hypothetical protein; Validated; Region: PRK07411 1283330000695 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1283330000696 ATP binding site [chemical binding]; other site 1283330000697 substrate interface [chemical binding]; other site 1283330000698 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1283330000699 active site residue [active] 1283330000700 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 1283330000701 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1283330000702 ATP binding site [chemical binding]; other site 1283330000703 substrate interface [chemical binding]; other site 1283330000704 Ubiquitin-like proteins; Region: UBQ; cl00155 1283330000705 charged pocket; other site 1283330000706 hydrophobic patch; other site 1283330000707 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1283330000708 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 1283330000709 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1283330000710 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1283330000711 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1283330000712 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1283330000713 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1283330000714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330000715 Walker A motif; other site 1283330000716 ATP binding site [chemical binding]; other site 1283330000717 Walker B motif; other site 1283330000718 arginine finger; other site 1283330000719 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330000720 NifU-like domain; Region: NifU; pfam01106 1283330000721 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1283330000722 homotrimer interaction site [polypeptide binding]; other site 1283330000723 putative active site [active] 1283330000724 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1283330000725 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1283330000726 Zn2+ binding site [ion binding]; other site 1283330000727 Mg2+ binding site [ion binding]; other site 1283330000728 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1283330000729 synthetase active site [active] 1283330000730 NTP binding site [chemical binding]; other site 1283330000731 metal binding site [ion binding]; metal-binding site 1283330000732 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1283330000733 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1283330000734 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1283330000735 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1283330000736 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1283330000737 catalytic site [active] 1283330000738 G-X2-G-X-G-K; other site 1283330000739 hypothetical protein; Provisional; Region: PRK11820 1283330000740 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1283330000741 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1283330000742 ribonuclease PH; Reviewed; Region: rph; PRK00173 1283330000743 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1283330000744 hexamer interface [polypeptide binding]; other site 1283330000745 active site 1283330000746 Tic20-like protein; Region: Tic20; pfam09685 1283330000747 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1283330000748 putative active site [active] 1283330000749 putative catalytic site [active] 1283330000750 putative DNA binding site [nucleotide binding]; other site 1283330000751 putative phosphate binding site [ion binding]; other site 1283330000752 metal binding site A [ion binding]; metal-binding site 1283330000753 putative AP binding site [nucleotide binding]; other site 1283330000754 putative metal binding site B [ion binding]; other site 1283330000755 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283330000756 active site 1283330000757 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 1283330000758 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1283330000759 feedback inhibition sensing region; other site 1283330000760 homohexameric interface [polypeptide binding]; other site 1283330000761 nucleotide binding site [chemical binding]; other site 1283330000762 N-acetyl-L-glutamate binding site [chemical binding]; other site 1283330000763 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1283330000764 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1283330000765 active site 1283330000766 substrate binding site [chemical binding]; other site 1283330000767 metal binding site [ion binding]; metal-binding site 1283330000768 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1283330000769 trimer interface [polypeptide binding]; other site 1283330000770 active site 1283330000771 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1283330000772 Flavoprotein; Region: Flavoprotein; pfam02441 1283330000773 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1283330000774 hypothetical protein; Reviewed; Region: PRK00024 1283330000775 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1283330000776 MPN+ (JAMM) motif; other site 1283330000777 Zinc-binding site [ion binding]; other site 1283330000778 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1283330000779 Transglycosylase; Region: Transgly; cl17702 1283330000780 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1283330000781 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1283330000782 thiS-thiF/thiG interaction site; other site 1283330000783 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1283330000784 ThiS interaction site; other site 1283330000785 putative active site [active] 1283330000786 tetramer interface [polypeptide binding]; other site 1283330000787 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1283330000788 HemN family oxidoreductase; Provisional; Region: PRK05660 1283330000789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283330000790 FeS/SAM binding site; other site 1283330000791 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1283330000792 active site 1283330000793 dimerization interface [polypeptide binding]; other site 1283330000794 Domain of unknown function (DUF4426); Region: DUF4426; pfam14467 1283330000795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330000796 S-adenosylmethionine binding site [chemical binding]; other site 1283330000797 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1283330000798 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1283330000799 hypothetical protein; Validated; Region: PRK05090 1283330000800 YGGT family; Region: YGGT; pfam02325 1283330000801 YGGT family; Region: YGGT; pfam02325 1283330000802 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1283330000803 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1283330000804 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1283330000805 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1283330000806 catalytic residue [active] 1283330000807 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1283330000808 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1283330000809 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1283330000810 Walker A motif; other site 1283330000811 ATP binding site [chemical binding]; other site 1283330000812 Walker B motif; other site 1283330000813 TM2 domain; Region: TM2; pfam05154 1283330000814 dihydroorotase; Validated; Region: pyrC; PRK09357 1283330000815 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1283330000816 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1283330000817 active site 1283330000818 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1283330000819 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1283330000820 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1283330000821 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1283330000822 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283330000823 active site 1283330000824 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1283330000825 hypothetical protein; Validated; Region: PRK00228 1283330000826 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1283330000827 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1283330000828 glutathione synthetase; Provisional; Region: PRK05246 1283330000829 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1283330000830 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1283330000831 Response regulator receiver domain; Region: Response_reg; pfam00072 1283330000832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330000833 active site 1283330000834 phosphorylation site [posttranslational modification] 1283330000835 intermolecular recognition site; other site 1283330000836 dimerization interface [polypeptide binding]; other site 1283330000837 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1283330000838 RNA methyltransferase, RsmE family; Region: TIGR00046 1283330000839 Protein of unknown function (DUF3087); Region: DUF3087; pfam11286 1283330000840 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK07030 1283330000841 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1283330000842 inhibitor-cofactor binding pocket; inhibition site 1283330000843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330000844 catalytic residue [active] 1283330000845 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1283330000846 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1283330000847 hypothetical protein; Provisional; Region: PRK03757 1283330000848 Cache domain; Region: Cache_1; pfam02743 1283330000849 PAS fold; Region: PAS_3; pfam08447 1283330000850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330000851 putative active site [active] 1283330000852 heme pocket [chemical binding]; other site 1283330000853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283330000854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330000855 dimer interface [polypeptide binding]; other site 1283330000856 phosphorylation site [posttranslational modification] 1283330000857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330000858 ATP binding site [chemical binding]; other site 1283330000859 Mg2+ binding site [ion binding]; other site 1283330000860 G-X-G motif; other site 1283330000861 Response regulator receiver domain; Region: Response_reg; pfam00072 1283330000862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330000863 active site 1283330000864 phosphorylation site [posttranslational modification] 1283330000865 intermolecular recognition site; other site 1283330000866 dimerization interface [polypeptide binding]; other site 1283330000867 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1283330000868 active site 1283330000869 metal binding site [ion binding]; metal-binding site 1283330000870 homotetramer interface [polypeptide binding]; other site 1283330000871 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1283330000872 HipA N-terminal domain; Region: Couple_hipA; cl11853 1283330000873 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1283330000874 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1283330000875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1283330000876 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1283330000877 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1283330000878 putative RNA binding site [nucleotide binding]; other site 1283330000879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330000880 S-adenosylmethionine binding site [chemical binding]; other site 1283330000881 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1283330000882 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1283330000883 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1283330000884 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1283330000885 Walker A/P-loop; other site 1283330000886 ATP binding site [chemical binding]; other site 1283330000887 Q-loop/lid; other site 1283330000888 ABC transporter signature motif; other site 1283330000889 Walker B; other site 1283330000890 D-loop; other site 1283330000891 H-loop/switch region; other site 1283330000892 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283330000893 dimer interface [polypeptide binding]; other site 1283330000894 putative CheW interface [polypeptide binding]; other site 1283330000895 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1283330000896 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1283330000897 proposed catalytic triad [active] 1283330000898 conserved cys residue [active] 1283330000899 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1283330000900 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1283330000901 DNA binding site [nucleotide binding] 1283330000902 catalytic residue [active] 1283330000903 H2TH interface [polypeptide binding]; other site 1283330000904 putative catalytic residues [active] 1283330000905 turnover-facilitating residue; other site 1283330000906 intercalation triad [nucleotide binding]; other site 1283330000907 8OG recognition residue [nucleotide binding]; other site 1283330000908 putative reading head residues; other site 1283330000909 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1283330000910 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1283330000911 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1283330000912 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1283330000913 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1283330000914 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1283330000915 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1283330000916 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1283330000917 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1283330000918 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1283330000919 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1283330000920 active site 1283330000921 (T/H)XGH motif; other site 1283330000922 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1283330000923 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1283330000924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330000925 S-adenosylmethionine binding site [chemical binding]; other site 1283330000926 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1283330000927 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1283330000928 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1283330000929 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1283330000930 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1283330000931 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1283330000932 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1283330000933 ATP binding site [chemical binding]; other site 1283330000934 Mg++ binding site [ion binding]; other site 1283330000935 motif III; other site 1283330000936 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283330000937 nucleotide binding region [chemical binding]; other site 1283330000938 ATP-binding site [chemical binding]; other site 1283330000939 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1283330000940 FAD binding site [chemical binding]; other site 1283330000941 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1283330000942 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1283330000943 homotetramer interface [polypeptide binding]; other site 1283330000944 ligand binding site [chemical binding]; other site 1283330000945 catalytic site [active] 1283330000946 NAD binding site [chemical binding]; other site 1283330000947 Cytochrome C' Region: Cytochrom_C_2; pfam01322 1283330000948 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1283330000949 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1283330000950 nucleotide binding pocket [chemical binding]; other site 1283330000951 K-X-D-G motif; other site 1283330000952 catalytic site [active] 1283330000953 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1283330000954 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1283330000955 L-fucose transporter; Provisional; Region: PRK10133; cl17665 1283330000956 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1283330000957 non-specific DNA interactions [nucleotide binding]; other site 1283330000958 DNA binding site [nucleotide binding] 1283330000959 sequence specific DNA binding site [nucleotide binding]; other site 1283330000960 putative cAMP binding site [chemical binding]; other site 1283330000961 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1283330000962 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1283330000963 nucleotide binding site [chemical binding]; other site 1283330000964 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1283330000965 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1283330000966 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1283330000967 shikimate binding site; other site 1283330000968 NAD(P) binding site [chemical binding]; other site 1283330000969 DctM-like transporters; Region: DctM; pfam06808 1283330000970 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1283330000971 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1283330000972 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1283330000973 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1283330000974 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1283330000975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330000976 active site 1283330000977 phosphorylation site [posttranslational modification] 1283330000978 intermolecular recognition site; other site 1283330000979 dimerization interface [polypeptide binding]; other site 1283330000980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330000981 Walker A motif; other site 1283330000982 ATP binding site [chemical binding]; other site 1283330000983 Walker B motif; other site 1283330000984 arginine finger; other site 1283330000985 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330000986 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1283330000987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330000988 dimer interface [polypeptide binding]; other site 1283330000989 phosphorylation site [posttranslational modification] 1283330000990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330000991 ATP binding site [chemical binding]; other site 1283330000992 Mg2+ binding site [ion binding]; other site 1283330000993 G-X-G motif; other site 1283330000994 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330000995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330000996 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283330000997 dimerization interface [polypeptide binding]; other site 1283330000998 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1283330000999 active site 1283330001000 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1283330001001 dimer interface [polypeptide binding]; other site 1283330001002 non-prolyl cis peptide bond; other site 1283330001003 insertion regions; other site 1283330001004 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1283330001005 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1283330001006 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1283330001007 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1283330001008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1283330001009 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283330001010 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330001011 membrane-bound complex binding site; other site 1283330001012 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283330001013 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1283330001014 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1283330001015 phosphate binding site [ion binding]; other site 1283330001016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330001017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330001018 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283330001019 putative effector binding pocket; other site 1283330001020 dimerization interface [polypeptide binding]; other site 1283330001021 Uncharacterized protein required for formate dehydrogenase activity [Energy production and conversion]; Region: FdhD; COG1526 1283330001022 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1283330001023 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1283330001024 [4Fe-4S] binding site [ion binding]; other site 1283330001025 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1283330001026 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1283330001027 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1283330001028 molybdopterin cofactor binding site; other site 1283330001029 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1283330001030 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1283330001031 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1283330001032 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1283330001033 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1283330001034 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1283330001035 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1283330001036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283330001037 FeS/SAM binding site; other site 1283330001038 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1283330001039 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1283330001040 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330001041 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330001042 DNA binding residues [nucleotide binding] 1283330001043 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283330001044 FecR protein; Region: FecR; pfam04773 1283330001045 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 1283330001046 phasin family protein; Region: phasin; TIGR01841 1283330001047 Nucleoside 2-deoxyribosyltransferase [Nucleotide transport and metabolism]; Region: COG3613 1283330001048 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1283330001049 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1283330001050 HlyD family secretion protein; Region: HlyD; pfam00529 1283330001051 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283330001052 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283330001053 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1283330001054 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1283330001055 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1283330001056 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1283330001057 Outer membrane efflux protein; Region: OEP; pfam02321 1283330001058 Outer membrane efflux protein; Region: OEP; pfam02321 1283330001059 transcriptional regulator; Provisional; Region: PRK10632 1283330001060 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330001061 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283330001062 putative effector binding pocket; other site 1283330001063 dimerization interface [polypeptide binding]; other site 1283330001064 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1283330001065 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283330001066 ligand binding site [chemical binding]; other site 1283330001067 Restriction endonuclease; Region: Mrr_cat; pfam04471 1283330001068 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1283330001069 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 1283330001070 putative active site [active] 1283330001071 putative metal binding site [ion binding]; other site 1283330001072 malate:quinone oxidoreductase; Validated; Region: PRK05257 1283330001073 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1283330001074 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 1283330001075 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1283330001076 glucokinase; Provisional; Region: glk; PRK00292 1283330001077 glucokinase, proteobacterial type; Region: glk; TIGR00749 1283330001078 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1283330001079 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1283330001080 putative metal binding site [ion binding]; other site 1283330001081 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1283330001082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330001083 putative substrate translocation pore; other site 1283330001084 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330001085 salt bridge; other site 1283330001086 non-specific DNA binding site [nucleotide binding]; other site 1283330001087 sequence-specific DNA binding site [nucleotide binding]; other site 1283330001088 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1283330001089 Helix-turn-helix domain; Region: HTH_39; pfam14090 1283330001090 Methyltransferase domain; Region: Methyltransf_32; pfam13679 1283330001091 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1283330001092 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1283330001093 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1283330001094 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1283330001095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1283330001096 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1283330001097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1283330001098 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1283330001099 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1283330001100 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1283330001101 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1283330001102 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 1283330001103 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 1283330001104 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1283330001105 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1283330001106 ligand binding site [chemical binding]; other site 1283330001107 flexible hinge region; other site 1283330001108 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1283330001109 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 1283330001110 FAD binding pocket [chemical binding]; other site 1283330001111 FAD binding motif [chemical binding]; other site 1283330001112 phosphate binding motif [ion binding]; other site 1283330001113 beta-alpha-beta structure motif; other site 1283330001114 NAD binding pocket [chemical binding]; other site 1283330001115 Iron coordination center [ion binding]; other site 1283330001116 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1283330001117 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 1283330001118 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 1283330001119 nickel binding site [ion binding]; other site 1283330001120 hypothetical protein; Provisional; Region: PRK10649 1283330001121 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1283330001122 Sulfatase; Region: Sulfatase; pfam00884 1283330001123 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1283330001124 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1283330001125 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1283330001126 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 1283330001127 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 1283330001128 P-loop; other site 1283330001129 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1283330001130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283330001131 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 1283330001132 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 1283330001133 ACS interaction site; other site 1283330001134 CODH interaction site; other site 1283330001135 cubane metal cluster (B-cluster) [ion binding]; other site 1283330001136 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 1283330001137 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1283330001138 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1283330001139 oxidative damage protection protein; Provisional; Region: PRK05408 1283330001140 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1283330001141 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1283330001142 minor groove reading motif; other site 1283330001143 helix-hairpin-helix signature motif; other site 1283330001144 substrate binding pocket [chemical binding]; other site 1283330001145 active site 1283330001146 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1283330001147 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1283330001148 DNA binding and oxoG recognition site [nucleotide binding] 1283330001149 AsmA family; Region: AsmA; pfam05170 1283330001150 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1283330001151 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1283330001152 hypothetical protein; Validated; Region: PRK06201 1283330001153 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1283330001154 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1283330001155 putative active site pocket [active] 1283330001156 4-fold oligomerization interface [polypeptide binding]; other site 1283330001157 metal binding residues [ion binding]; metal-binding site 1283330001158 3-fold/trimer interface [polypeptide binding]; other site 1283330001159 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1283330001160 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1283330001161 putative active site [active] 1283330001162 oxyanion strand; other site 1283330001163 catalytic triad [active] 1283330001164 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 1283330001165 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1283330001166 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1283330001167 catalytic residues [active] 1283330001168 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1283330001169 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1283330001170 substrate binding site [chemical binding]; other site 1283330001171 glutamase interaction surface [polypeptide binding]; other site 1283330001172 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1283330001173 C-terminal peptidase (prc); Region: prc; TIGR00225 1283330001174 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1283330001175 protein binding site [polypeptide binding]; other site 1283330001176 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1283330001177 Catalytic dyad [active] 1283330001178 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 1283330001179 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1283330001180 Peptidase family M23; Region: Peptidase_M23; pfam01551 1283330001181 phosphoglyceromutase; Provisional; Region: PRK05434 1283330001182 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1283330001183 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1283330001184 active site residue [active] 1283330001185 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1283330001186 GSH binding site [chemical binding]; other site 1283330001187 catalytic residues [active] 1283330001188 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1283330001189 SecA binding site; other site 1283330001190 Preprotein binding site; other site 1283330001191 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1283330001192 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1283330001193 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330001194 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283330001195 dimerization interface [polypeptide binding]; other site 1283330001196 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 1283330001197 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1283330001198 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283330001199 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1283330001200 Protein of unknown function (DUF330); Region: DUF330; cl01135 1283330001201 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1283330001202 mce related protein; Region: MCE; pfam02470 1283330001203 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1283330001204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330001205 Walker A/P-loop; other site 1283330001206 ATP binding site [chemical binding]; other site 1283330001207 Q-loop/lid; other site 1283330001208 ABC transporter signature motif; other site 1283330001209 Walker B; other site 1283330001210 D-loop; other site 1283330001211 H-loop/switch region; other site 1283330001212 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1283330001213 Permease; Region: Permease; pfam02405 1283330001214 Protein of unknown function, DUF480; Region: DUF480; pfam04337 1283330001215 Protein of unknown function (DUF2388); Region: DUF2388; pfam09498 1283330001216 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1283330001217 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1283330001218 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1283330001219 Walker A motif; other site 1283330001220 ATP binding site [chemical binding]; other site 1283330001221 Walker B motif; other site 1283330001222 Protein of unknown function (DUF502); Region: DUF502; cl01107 1283330001223 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1283330001224 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1283330001225 putative active site [active] 1283330001226 putative metal binding residues [ion binding]; other site 1283330001227 signature motif; other site 1283330001228 putative triphosphate binding site [ion binding]; other site 1283330001229 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1283330001230 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 1283330001231 Cl binding site [ion binding]; other site 1283330001232 oligomer interface [polypeptide binding]; other site 1283330001233 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1283330001234 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1283330001235 acetylornithine deacetylase; Provisional; Region: PRK05111 1283330001236 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1283330001237 metal binding site [ion binding]; metal-binding site 1283330001238 putative dimer interface [polypeptide binding]; other site 1283330001239 N-acetylglutamate synthase; Validated; Region: PRK05279 1283330001240 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1283330001241 putative feedback inhibition sensing region; other site 1283330001242 putative nucleotide binding site [chemical binding]; other site 1283330001243 putative substrate binding site [chemical binding]; other site 1283330001244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1283330001245 Coenzyme A binding pocket [chemical binding]; other site 1283330001246 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1283330001247 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1283330001248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330001249 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330001250 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330001251 metal binding site [ion binding]; metal-binding site 1283330001252 active site 1283330001253 I-site; other site 1283330001254 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1283330001255 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1283330001256 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330001257 Phytase; Region: Phytase; cl17685 1283330001258 Phytase; Region: Phytase; cl17685 1283330001259 TolQ protein; Region: tolQ; TIGR02796 1283330001260 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1283330001261 TolR protein; Region: tolR; TIGR02801 1283330001262 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1283330001263 glutamate--cysteine ligase; Provisional; Region: PRK02107 1283330001264 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1283330001265 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1283330001266 CoenzymeA binding site [chemical binding]; other site 1283330001267 subunit interaction site [polypeptide binding]; other site 1283330001268 PHB binding site; other site 1283330001269 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1283330001270 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1283330001271 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1283330001272 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1283330001273 RNA binding site [nucleotide binding]; other site 1283330001274 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1283330001275 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 1283330001276 TPR repeat; Region: TPR_11; pfam13414 1283330001277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283330001278 TPR motif; other site 1283330001279 binding surface 1283330001280 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1283330001281 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1283330001282 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 1283330001283 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1283330001284 DXD motif; other site 1283330001285 PilZ domain; Region: PilZ; pfam07238 1283330001286 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 1283330001287 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 1283330001288 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1283330001289 P-loop; other site 1283330001290 Magnesium ion binding site [ion binding]; other site 1283330001291 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1283330001292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330001293 active site 1283330001294 phosphorylation site [posttranslational modification] 1283330001295 intermolecular recognition site; other site 1283330001296 dimerization interface [polypeptide binding]; other site 1283330001297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283330001298 DNA binding site [nucleotide binding] 1283330001299 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1283330001300 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283330001301 dimerization interface [polypeptide binding]; other site 1283330001302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330001303 ATP binding site [chemical binding]; other site 1283330001304 Mg2+ binding site [ion binding]; other site 1283330001305 G-X-G motif; other site 1283330001306 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1283330001307 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1283330001308 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1283330001309 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1283330001310 RNA binding surface [nucleotide binding]; other site 1283330001311 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330001312 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1283330001313 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1283330001314 dimer interface [polypeptide binding]; other site 1283330001315 NADP binding site [chemical binding]; other site 1283330001316 catalytic residues [active] 1283330001317 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1283330001318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283330001319 DNA-binding site [nucleotide binding]; DNA binding site 1283330001320 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1283330001321 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1283330001322 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1283330001323 putative active site [active] 1283330001324 catalytic residue [active] 1283330001325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330001326 D-galactonate transporter; Region: 2A0114; TIGR00893 1283330001327 putative substrate translocation pore; other site 1283330001328 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1283330001329 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1283330001330 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1283330001331 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1283330001332 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1283330001333 putative ligand binding site [chemical binding]; other site 1283330001334 NAD binding site [chemical binding]; other site 1283330001335 catalytic site [active] 1283330001336 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1283330001337 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1283330001338 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1283330001339 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1283330001340 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1283330001341 putative active site [active] 1283330001342 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 1283330001343 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1283330001344 DXD motif; other site 1283330001345 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1283330001346 active site 1283330001347 O-Antigen ligase; Region: Wzy_C; pfam04932 1283330001348 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1283330001349 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283330001350 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1283330001351 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1283330001352 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 1283330001353 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1283330001354 SLBB domain; Region: SLBB; pfam10531 1283330001355 AAA domain; Region: AAA_31; pfam13614 1283330001356 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1283330001357 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1283330001358 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1283330001359 putative NAD(P) binding site [chemical binding]; other site 1283330001360 active site 1283330001361 putative substrate binding site [chemical binding]; other site 1283330001362 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1283330001363 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1283330001364 dimerization interface [polypeptide binding]; other site 1283330001365 domain crossover interface; other site 1283330001366 redox-dependent activation switch; other site 1283330001367 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1283330001368 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1283330001369 active site 1283330001370 substrate-binding site [chemical binding]; other site 1283330001371 metal-binding site [ion binding] 1283330001372 ATP binding site [chemical binding]; other site 1283330001373 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1283330001374 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1283330001375 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1283330001376 putative active site [active] 1283330001377 catalytic site [active] 1283330001378 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1283330001379 putative active site [active] 1283330001380 catalytic site [active] 1283330001381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1283330001382 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1283330001383 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1283330001384 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1283330001385 dimer interface [polypeptide binding]; other site 1283330001386 ADP-ribose binding site [chemical binding]; other site 1283330001387 active site 1283330001388 nudix motif; other site 1283330001389 metal binding site [ion binding]; metal-binding site 1283330001390 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1283330001391 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1283330001392 active site 1283330001393 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1283330001394 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1283330001395 active site 1283330001396 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1283330001397 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1283330001398 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1283330001399 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1283330001400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283330001401 putative DNA binding site [nucleotide binding]; other site 1283330001402 putative Zn2+ binding site [ion binding]; other site 1283330001403 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1283330001404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330001405 S-adenosylmethionine binding site [chemical binding]; other site 1283330001406 transketolase; Reviewed; Region: PRK12753 1283330001407 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1283330001408 TPP-binding site [chemical binding]; other site 1283330001409 dimer interface [polypeptide binding]; other site 1283330001410 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1283330001411 PYR/PP interface [polypeptide binding]; other site 1283330001412 dimer interface [polypeptide binding]; other site 1283330001413 TPP binding site [chemical binding]; other site 1283330001414 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1283330001415 erythrose-4-phosphate dehydrogenase; Region: E4PD_g-proteo; TIGR01532 1283330001416 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1283330001417 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1283330001418 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1283330001419 Phosphoglycerate kinase; Region: PGK; pfam00162 1283330001420 substrate binding site [chemical binding]; other site 1283330001421 hinge regions; other site 1283330001422 ADP binding site [chemical binding]; other site 1283330001423 catalytic site [active] 1283330001424 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1283330001425 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1283330001426 intersubunit interface [polypeptide binding]; other site 1283330001427 active site 1283330001428 zinc binding site [ion binding]; other site 1283330001429 Na+ binding site [ion binding]; other site 1283330001430 Domain of unknown function (DUF336); Region: DUF336; cl01249 1283330001431 putative oxidoreductase; Provisional; Region: PRK11579 1283330001432 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283330001433 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1283330001434 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1283330001435 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1283330001436 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1283330001437 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1283330001438 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1283330001439 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1283330001440 Protein of unknown function (DUF808); Region: DUF808; pfam05661 1283330001441 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1283330001442 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1283330001443 Cytochrome c; Region: Cytochrom_C; pfam00034 1283330001444 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1283330001445 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1283330001446 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1283330001447 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1283330001448 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 1283330001449 active site residues [active] 1283330001450 dimer interface [polypeptide binding]; other site 1283330001451 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1283330001452 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1283330001453 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1283330001454 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1283330001455 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1283330001456 hexamer interface [polypeptide binding]; other site 1283330001457 ligand binding site [chemical binding]; other site 1283330001458 putative active site [active] 1283330001459 NAD(P) binding site [chemical binding]; other site 1283330001460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283330001461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283330001462 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 1283330001463 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1283330001464 putative C-terminal domain interface [polypeptide binding]; other site 1283330001465 putative GSH binding site (G-site) [chemical binding]; other site 1283330001466 putative dimer interface [polypeptide binding]; other site 1283330001467 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1283330001468 N-terminal domain interface [polypeptide binding]; other site 1283330001469 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1283330001470 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1283330001471 C-terminal domain interface [polypeptide binding]; other site 1283330001472 GSH binding site (G-site) [chemical binding]; other site 1283330001473 dimer interface [polypeptide binding]; other site 1283330001474 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1283330001475 N-terminal domain interface [polypeptide binding]; other site 1283330001476 putative dimer interface [polypeptide binding]; other site 1283330001477 active site 1283330001478 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1283330001479 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1283330001480 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330001481 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330001482 metal binding site [ion binding]; metal-binding site 1283330001483 active site 1283330001484 I-site; other site 1283330001485 putative transporter; Provisional; Region: PRK10504 1283330001486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330001487 putative substrate translocation pore; other site 1283330001488 TraX protein; Region: TraX; pfam05857 1283330001489 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1283330001490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330001491 putative substrate translocation pore; other site 1283330001492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1283330001493 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1283330001494 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1283330001495 putative acyl-acceptor binding pocket; other site 1283330001496 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1283330001497 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1283330001498 dimer interface [polypeptide binding]; other site 1283330001499 active site 1283330001500 heme binding site [chemical binding]; other site 1283330001501 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1283330001502 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1283330001503 active site 1283330001504 catalytic site [active] 1283330001505 substrate binding site [chemical binding]; other site 1283330001506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1283330001507 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1283330001508 Probable transposase; Region: OrfB_IS605; pfam01385 1283330001509 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1283330001510 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1283330001511 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1283330001512 ligand binding site [chemical binding]; other site 1283330001513 flexible hinge region; other site 1283330001514 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 1283330001515 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1283330001516 metal binding triad; other site 1283330001517 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1283330001518 active site 1283330001519 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1283330001520 ACT domain; Region: ACT_6; pfam13740 1283330001521 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1283330001522 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1283330001523 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1283330001524 dimerization domain [polypeptide binding]; other site 1283330001525 dimer interface [polypeptide binding]; other site 1283330001526 catalytic residues [active] 1283330001527 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1283330001528 EamA-like transporter family; Region: EamA; pfam00892 1283330001529 serine/threonine protein kinase; Provisional; Region: PRK11768 1283330001530 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1283330001531 DNA utilization protein GntX; Provisional; Region: PRK11595 1283330001532 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283330001533 active site 1283330001534 biotin synthase; Provisional; Region: PRK15108 1283330001535 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283330001536 FeS/SAM binding site; other site 1283330001537 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1283330001538 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1283330001539 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1283330001540 substrate-cofactor binding pocket; other site 1283330001541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330001542 catalytic residue [active] 1283330001543 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 1283330001544 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1283330001545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330001546 S-adenosylmethionine binding site [chemical binding]; other site 1283330001547 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1283330001548 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1283330001549 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1283330001550 putative acyl-acceptor binding pocket; other site 1283330001551 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1283330001552 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1283330001553 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1283330001554 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1283330001555 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1283330001556 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1283330001557 pantothenate kinase; Reviewed; Region: PRK13322 1283330001558 elongation factor Tu; Reviewed; Region: PRK00049 1283330001559 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1283330001560 G1 box; other site 1283330001561 GEF interaction site [polypeptide binding]; other site 1283330001562 GTP/Mg2+ binding site [chemical binding]; other site 1283330001563 Switch I region; other site 1283330001564 G2 box; other site 1283330001565 G3 box; other site 1283330001566 Switch II region; other site 1283330001567 G4 box; other site 1283330001568 G5 box; other site 1283330001569 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1283330001570 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1283330001571 Antibiotic Binding Site [chemical binding]; other site 1283330001572 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1283330001573 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 1283330001574 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1283330001575 putative homodimer interface [polypeptide binding]; other site 1283330001576 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1283330001577 heterodimer interface [polypeptide binding]; other site 1283330001578 homodimer interface [polypeptide binding]; other site 1283330001579 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1283330001580 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1283330001581 23S rRNA interface [nucleotide binding]; other site 1283330001582 L7/L12 interface [polypeptide binding]; other site 1283330001583 putative thiostrepton binding site; other site 1283330001584 L25 interface [polypeptide binding]; other site 1283330001585 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1283330001586 mRNA/rRNA interface [nucleotide binding]; other site 1283330001587 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1283330001588 23S rRNA interface [nucleotide binding]; other site 1283330001589 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1283330001590 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1283330001591 core dimer interface [polypeptide binding]; other site 1283330001592 peripheral dimer interface [polypeptide binding]; other site 1283330001593 L10 interface [polypeptide binding]; other site 1283330001594 L11 interface [polypeptide binding]; other site 1283330001595 putative EF-Tu interaction site [polypeptide binding]; other site 1283330001596 putative EF-G interaction site [polypeptide binding]; other site 1283330001597 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1283330001598 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1283330001599 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1283330001600 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1283330001601 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1283330001602 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1283330001603 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1283330001604 RPB3 interaction site [polypeptide binding]; other site 1283330001605 RPB1 interaction site [polypeptide binding]; other site 1283330001606 RPB11 interaction site [polypeptide binding]; other site 1283330001607 RPB10 interaction site [polypeptide binding]; other site 1283330001608 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1283330001609 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1283330001610 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1283330001611 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1283330001612 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1283330001613 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1283330001614 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1283330001615 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1283330001616 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1283330001617 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1283330001618 DNA binding site [nucleotide binding] 1283330001619 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1283330001620 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1283330001621 S17 interaction site [polypeptide binding]; other site 1283330001622 S8 interaction site; other site 1283330001623 16S rRNA interaction site [nucleotide binding]; other site 1283330001624 streptomycin interaction site [chemical binding]; other site 1283330001625 23S rRNA interaction site [nucleotide binding]; other site 1283330001626 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1283330001627 30S ribosomal protein S7; Validated; Region: PRK05302 1283330001628 elongation factor G; Reviewed; Region: PRK00007 1283330001629 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1283330001630 Switch I region; other site 1283330001631 G2 box; other site 1283330001632 putative GEF interaction site [polypeptide binding]; other site 1283330001633 G3 box; other site 1283330001634 Switch II region; other site 1283330001635 GTP/Mg2+ binding site [chemical binding]; other site 1283330001636 G4 box; other site 1283330001637 G5 box; other site 1283330001638 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1283330001639 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1283330001640 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1283330001641 elongation factor Tu; Reviewed; Region: PRK00049 1283330001642 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1283330001643 G1 box; other site 1283330001644 GEF interaction site [polypeptide binding]; other site 1283330001645 GTP/Mg2+ binding site [chemical binding]; other site 1283330001646 Switch I region; other site 1283330001647 G2 box; other site 1283330001648 G3 box; other site 1283330001649 Switch II region; other site 1283330001650 G4 box; other site 1283330001651 G5 box; other site 1283330001652 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1283330001653 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1283330001654 Antibiotic Binding Site [chemical binding]; other site 1283330001655 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1283330001656 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1283330001657 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1283330001658 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1283330001659 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1283330001660 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1283330001661 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1283330001662 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1283330001663 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1283330001664 protein-rRNA interface [nucleotide binding]; other site 1283330001665 putative translocon binding site; other site 1283330001666 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1283330001667 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1283330001668 G-X-X-G motif; other site 1283330001669 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1283330001670 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1283330001671 23S rRNA interface [nucleotide binding]; other site 1283330001672 5S rRNA interface [nucleotide binding]; other site 1283330001673 putative antibiotic binding site [chemical binding]; other site 1283330001674 L25 interface [polypeptide binding]; other site 1283330001675 L27 interface [polypeptide binding]; other site 1283330001676 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1283330001677 23S rRNA interface [nucleotide binding]; other site 1283330001678 putative translocon interaction site; other site 1283330001679 signal recognition particle (SRP54) interaction site; other site 1283330001680 L23 interface [polypeptide binding]; other site 1283330001681 trigger factor interaction site; other site 1283330001682 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1283330001683 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1283330001684 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1283330001685 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1283330001686 RNA binding site [nucleotide binding]; other site 1283330001687 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1283330001688 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1283330001689 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1283330001690 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1283330001691 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1283330001692 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1283330001693 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1283330001694 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1283330001695 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1283330001696 5S rRNA interface [nucleotide binding]; other site 1283330001697 23S rRNA interface [nucleotide binding]; other site 1283330001698 L5 interface [polypeptide binding]; other site 1283330001699 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1283330001700 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1283330001701 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1283330001702 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1283330001703 23S rRNA binding site [nucleotide binding]; other site 1283330001704 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1283330001705 preprotein translocase, SecY subunit; Region: 3a0501s007; TIGR00967 1283330001706 SecY translocase; Region: SecY; pfam00344 1283330001707 Ribosomal protein L36 [Translation, ribosomal structure and biogenesis]; Region: RpmJ; COG0257 1283330001708 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1283330001709 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1283330001710 30S ribosomal protein S11; Validated; Region: PRK05309 1283330001711 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1283330001712 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1283330001713 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1283330001714 RNA binding surface [nucleotide binding]; other site 1283330001715 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1283330001716 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1283330001717 alphaNTD homodimer interface [polypeptide binding]; other site 1283330001718 alphaNTD - beta interaction site [polypeptide binding]; other site 1283330001719 alphaNTD - beta' interaction site [polypeptide binding]; other site 1283330001720 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1283330001721 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1283330001722 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1283330001723 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1283330001724 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1283330001725 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1283330001726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330001727 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283330001728 putative substrate translocation pore; other site 1283330001729 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1283330001730 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1283330001731 dimer interface [polypeptide binding]; other site 1283330001732 ssDNA binding site [nucleotide binding]; other site 1283330001733 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1283330001734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330001735 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330001736 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1283330001737 putative effector binding pocket; other site 1283330001738 putative dimerization interface [polypeptide binding]; other site 1283330001739 short chain dehydrogenase; Provisional; Region: PRK12937 1283330001740 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1283330001741 NADP binding site [chemical binding]; other site 1283330001742 homodimer interface [polypeptide binding]; other site 1283330001743 active site 1283330001744 substrate binding site [chemical binding]; other site 1283330001745 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1283330001746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330001747 NAD(P) binding site [chemical binding]; other site 1283330001748 active site 1283330001749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330001750 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1283330001751 NAD(P) binding site [chemical binding]; other site 1283330001752 active site 1283330001753 OmpW family; Region: OmpW; cl17427 1283330001754 OmpW family; Region: OmpW; cl17427 1283330001755 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 1283330001756 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1283330001757 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1283330001758 FtsX-like permease family; Region: FtsX; pfam02687 1283330001759 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1283330001760 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1283330001761 Walker A/P-loop; other site 1283330001762 ATP binding site [chemical binding]; other site 1283330001763 Q-loop/lid; other site 1283330001764 ABC transporter signature motif; other site 1283330001765 Walker B; other site 1283330001766 D-loop; other site 1283330001767 H-loop/switch region; other site 1283330001768 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 1283330001769 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1283330001770 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1283330001771 Predicted methyltransferase [General function prediction only]; Region: COG3897 1283330001772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1283330001773 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 1283330001774 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1283330001775 ATP cone domain; Region: ATP-cone; pfam03477 1283330001776 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1283330001777 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1283330001778 catalytic motif [active] 1283330001779 Zn binding site [ion binding]; other site 1283330001780 RibD C-terminal domain; Region: RibD_C; cl17279 1283330001781 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1283330001782 Lumazine binding domain; Region: Lum_binding; pfam00677 1283330001783 Lumazine binding domain; Region: Lum_binding; pfam00677 1283330001784 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 1283330001785 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1283330001786 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1283330001787 dimerization interface [polypeptide binding]; other site 1283330001788 active site 1283330001789 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1283330001790 homopentamer interface [polypeptide binding]; other site 1283330001791 active site 1283330001792 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1283330001793 thiamine monophosphate kinase; Provisional; Region: PRK05731 1283330001794 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1283330001795 ATP binding site [chemical binding]; other site 1283330001796 dimerization interface [polypeptide binding]; other site 1283330001797 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1283330001798 tetramer interfaces [polypeptide binding]; other site 1283330001799 binuclear metal-binding site [ion binding]; other site 1283330001800 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330001801 membrane-bound complex binding site; other site 1283330001802 hinge residues; other site 1283330001803 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1283330001804 dimerization interface [polypeptide binding]; other site 1283330001805 active site 1283330001806 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1283330001807 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1283330001808 cobalamin binding residues [chemical binding]; other site 1283330001809 putative BtuC binding residues; other site 1283330001810 dimer interface [polypeptide binding]; other site 1283330001811 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1283330001812 putative chaperone; Provisional; Region: PRK11678 1283330001813 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1283330001814 nucleotide binding site [chemical binding]; other site 1283330001815 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1283330001816 SBD interface [polypeptide binding]; other site 1283330001817 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1283330001818 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1283330001819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283330001820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330001821 dimer interface [polypeptide binding]; other site 1283330001822 phosphorylation site [posttranslational modification] 1283330001823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330001824 ATP binding site [chemical binding]; other site 1283330001825 Mg2+ binding site [ion binding]; other site 1283330001826 G-X-G motif; other site 1283330001827 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1283330001828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330001829 active site 1283330001830 phosphorylation site [posttranslational modification] 1283330001831 intermolecular recognition site; other site 1283330001832 dimerization interface [polypeptide binding]; other site 1283330001833 Response regulator receiver domain; Region: Response_reg; pfam00072 1283330001834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330001835 active site 1283330001836 phosphorylation site [posttranslational modification] 1283330001837 intermolecular recognition site; other site 1283330001838 dimerization interface [polypeptide binding]; other site 1283330001839 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1283330001840 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1283330001841 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1283330001842 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1283330001843 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1283330001844 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1283330001845 purine monophosphate binding site [chemical binding]; other site 1283330001846 dimer interface [polypeptide binding]; other site 1283330001847 putative catalytic residues [active] 1283330001848 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1283330001849 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1283330001850 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1283330001851 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1283330001852 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1283330001853 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1283330001854 FMN binding site [chemical binding]; other site 1283330001855 active site 1283330001856 catalytic residues [active] 1283330001857 substrate binding site [chemical binding]; other site 1283330001858 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 1283330001859 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1283330001860 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1283330001861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330001862 S-adenosylmethionine binding site [chemical binding]; other site 1283330001863 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1283330001864 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1283330001865 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1283330001866 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1283330001867 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1283330001868 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1283330001869 carboxyltransferase (CT) interaction site; other site 1283330001870 biotinylation site [posttranslational modification]; other site 1283330001871 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1283330001872 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1283330001873 active site 1283330001874 trimer interface [polypeptide binding]; other site 1283330001875 dimer interface [polypeptide binding]; other site 1283330001876 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1283330001877 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1283330001878 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1283330001879 DsbD alpha interface [polypeptide binding]; other site 1283330001880 catalytic residues [active] 1283330001881 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; pfam10095 1283330001882 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1283330001883 nudix motif; other site 1283330001884 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1283330001885 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1283330001886 putative ligand binding site [chemical binding]; other site 1283330001887 putative NAD binding site [chemical binding]; other site 1283330001888 catalytic site [active] 1283330001889 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 1283330001890 Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Region: NT_PAP_TUTase; cd05402 1283330001891 active site 1283330001892 metal binding triad [ion binding]; metal-binding site 1283330001893 translation initiation factor Sui1; Validated; Region: PRK06824 1283330001894 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1283330001895 putative rRNA binding site [nucleotide binding]; other site 1283330001896 arginine decarboxylase; Provisional; Region: PRK05354 1283330001897 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1283330001898 dimer interface [polypeptide binding]; other site 1283330001899 active site 1283330001900 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1283330001901 catalytic residues [active] 1283330001902 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1283330001903 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1283330001904 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1283330001905 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283330001906 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283330001907 Ligand Binding Site [chemical binding]; other site 1283330001908 SdiA-regulated; Region: SdiA-regulated; pfam06977 1283330001909 SdiA-regulated; Region: SdiA-regulated; cd09971 1283330001910 putative active site [active] 1283330001911 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1283330001912 amphipathic channel; other site 1283330001913 Asn-Pro-Ala signature motifs; other site 1283330001914 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1283330001915 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1283330001916 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1283330001917 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1283330001918 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1283330001919 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1283330001920 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1283330001921 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1283330001922 nucleophile elbow; other site 1283330001923 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1283330001924 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1283330001925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330001926 S-adenosylmethionine binding site [chemical binding]; other site 1283330001927 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1283330001928 homodimer interface [polypeptide binding]; other site 1283330001929 chemical substrate binding site [chemical binding]; other site 1283330001930 oligomer interface [polypeptide binding]; other site 1283330001931 metal binding site [ion binding]; metal-binding site 1283330001932 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 1283330001933 homodimer interface [polypeptide binding]; other site 1283330001934 active site 1283330001935 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1283330001936 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1283330001937 Walker A/P-loop; other site 1283330001938 ATP binding site [chemical binding]; other site 1283330001939 Q-loop/lid; other site 1283330001940 ABC transporter signature motif; other site 1283330001941 Walker B; other site 1283330001942 D-loop; other site 1283330001943 H-loop/switch region; other site 1283330001944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330001945 dimer interface [polypeptide binding]; other site 1283330001946 conserved gate region; other site 1283330001947 putative PBP binding loops; other site 1283330001948 ABC-ATPase subunit interface; other site 1283330001949 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1283330001950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330001951 dimer interface [polypeptide binding]; other site 1283330001952 conserved gate region; other site 1283330001953 putative PBP binding loops; other site 1283330001954 ABC-ATPase subunit interface; other site 1283330001955 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1283330001956 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330001957 substrate binding pocket [chemical binding]; other site 1283330001958 membrane-bound complex binding site; other site 1283330001959 hinge residues; other site 1283330001960 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1283330001961 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1283330001962 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1283330001963 Moco binding site; other site 1283330001964 metal coordination site [ion binding]; other site 1283330001965 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1283330001966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330001967 NAD(P) binding site [chemical binding]; other site 1283330001968 active site 1283330001969 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1283330001970 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283330001971 dimer interface [polypeptide binding]; other site 1283330001972 active site 1283330001973 General stress protein [General function prediction only]; Region: GsiB; COG3729 1283330001974 Bacterial virulence factor haemolysin; Region: SMP_2; cl11479 1283330001975 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1283330001976 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1283330001977 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1283330001978 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1283330001979 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1283330001980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330001981 motif II; other site 1283330001982 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1283330001983 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 1283330001984 tetramer interface [polypeptide binding]; other site 1283330001985 catalytic Zn binding site [ion binding]; other site 1283330001986 NADP binding site [chemical binding]; other site 1283330001987 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1283330001988 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1283330001989 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1283330001990 active site residue [active] 1283330001991 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1283330001992 active site residue [active] 1283330001993 GTPase RsgA; Reviewed; Region: PRK12288 1283330001994 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1283330001995 RNA binding site [nucleotide binding]; other site 1283330001996 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1283330001997 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1283330001998 GTP/Mg2+ binding site [chemical binding]; other site 1283330001999 G4 box; other site 1283330002000 G5 box; other site 1283330002001 G1 box; other site 1283330002002 Switch I region; other site 1283330002003 G2 box; other site 1283330002004 G3 box; other site 1283330002005 Switch II region; other site 1283330002006 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1283330002007 catalytic site [active] 1283330002008 putative active site [active] 1283330002009 putative substrate binding site [chemical binding]; other site 1283330002010 dimer interface [polypeptide binding]; other site 1283330002011 epoxyqueuosine reductase; Region: TIGR00276 1283330002012 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1283330002013 putative carbohydrate kinase; Provisional; Region: PRK10565 1283330002014 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1283330002015 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1283330002016 putative substrate binding site [chemical binding]; other site 1283330002017 putative ATP binding site [chemical binding]; other site 1283330002018 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1283330002019 AMIN domain; Region: AMIN; pfam11741 1283330002020 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1283330002021 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1283330002022 active site 1283330002023 metal binding site [ion binding]; metal-binding site 1283330002024 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1283330002025 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1283330002026 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1283330002027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330002028 ATP binding site [chemical binding]; other site 1283330002029 Mg2+ binding site [ion binding]; other site 1283330002030 G-X-G motif; other site 1283330002031 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1283330002032 ATP binding site [chemical binding]; other site 1283330002033 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1283330002034 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1283330002035 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1283330002036 bacterial Hfq-like; Region: Hfq; cd01716 1283330002037 hexamer interface [polypeptide binding]; other site 1283330002038 Sm1 motif; other site 1283330002039 RNA binding site [nucleotide binding]; other site 1283330002040 Sm2 motif; other site 1283330002041 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1283330002042 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1283330002043 HflX GTPase family; Region: HflX; cd01878 1283330002044 G1 box; other site 1283330002045 GTP/Mg2+ binding site [chemical binding]; other site 1283330002046 Switch I region; other site 1283330002047 G2 box; other site 1283330002048 G3 box; other site 1283330002049 Switch II region; other site 1283330002050 G4 box; other site 1283330002051 G5 box; other site 1283330002052 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1283330002053 HflK protein; Region: hflK; TIGR01933 1283330002054 HflC protein; Region: hflC; TIGR01932 1283330002055 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1283330002056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1283330002057 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 1283330002058 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1283330002059 dimer interface [polypeptide binding]; other site 1283330002060 motif 1; other site 1283330002061 active site 1283330002062 motif 2; other site 1283330002063 motif 3; other site 1283330002064 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1283330002065 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1283330002066 GDP-binding site [chemical binding]; other site 1283330002067 ACT binding site; other site 1283330002068 IMP binding site; other site 1283330002069 ribonuclease R; Region: RNase_R; TIGR02063 1283330002070 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1283330002071 RNB domain; Region: RNB; pfam00773 1283330002072 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1283330002073 RNA binding site [nucleotide binding]; other site 1283330002074 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1283330002075 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1283330002076 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1283330002077 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1283330002078 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1283330002079 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1283330002080 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1283330002081 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1283330002082 replicative DNA helicase; Provisional; Region: PRK05748 1283330002083 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1283330002084 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1283330002085 Walker A motif; other site 1283330002086 ATP binding site [chemical binding]; other site 1283330002087 Walker B motif; other site 1283330002088 DNA binding loops [nucleotide binding] 1283330002089 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283330002090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330002091 hypothetical protein; Provisional; Region: PRK01254 1283330002092 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1283330002093 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1283330002094 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1283330002095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330002096 S-adenosylmethionine binding site [chemical binding]; other site 1283330002097 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1283330002098 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1283330002099 FAD binding pocket [chemical binding]; other site 1283330002100 FAD binding motif [chemical binding]; other site 1283330002101 phosphate binding motif [ion binding]; other site 1283330002102 beta-alpha-beta structure motif; other site 1283330002103 NAD binding pocket [chemical binding]; other site 1283330002104 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1283330002105 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1283330002106 active site 1283330002107 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1283330002108 catalytic triad [active] 1283330002109 dimer interface [polypeptide binding]; other site 1283330002110 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1283330002111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330002112 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1283330002113 Predicted metalloprotease [General function prediction only]; Region: COG2321 1283330002114 Predicted metal-binding protein [General function prediction only]; Region: COG3019 1283330002115 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1283330002116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330002117 S-adenosylmethionine binding site [chemical binding]; other site 1283330002118 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1283330002119 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1283330002120 AAA domain; Region: AAA_18; pfam13238 1283330002121 active site 1283330002122 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1283330002123 catalytic triad [active] 1283330002124 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1283330002125 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330002126 N-terminal plug; other site 1283330002127 ligand-binding site [chemical binding]; other site 1283330002128 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1283330002129 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1283330002130 TPP-binding site; other site 1283330002131 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1283330002132 PYR/PP interface [polypeptide binding]; other site 1283330002133 dimer interface [polypeptide binding]; other site 1283330002134 TPP binding site [chemical binding]; other site 1283330002135 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1283330002136 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1283330002137 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1283330002138 substrate binding pocket [chemical binding]; other site 1283330002139 chain length determination region; other site 1283330002140 substrate-Mg2+ binding site; other site 1283330002141 catalytic residues [active] 1283330002142 aspartate-rich region 1; other site 1283330002143 active site lid residues [active] 1283330002144 aspartate-rich region 2; other site 1283330002145 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1283330002146 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1283330002147 PAS domain S-box; Region: sensory_box; TIGR00229 1283330002148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330002149 putative active site [active] 1283330002150 heme pocket [chemical binding]; other site 1283330002151 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330002152 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330002153 metal binding site [ion binding]; metal-binding site 1283330002154 active site 1283330002155 I-site; other site 1283330002156 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283330002157 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1283330002158 dimer interface [polypeptide binding]; other site 1283330002159 substrate binding site [chemical binding]; other site 1283330002160 metal binding sites [ion binding]; metal-binding site 1283330002161 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 1283330002162 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1283330002163 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1283330002164 NAD binding site [chemical binding]; other site 1283330002165 substrate binding site [chemical binding]; other site 1283330002166 catalytic Zn binding site [ion binding]; other site 1283330002167 tetramer interface [polypeptide binding]; other site 1283330002168 structural Zn binding site [ion binding]; other site 1283330002169 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1283330002170 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1283330002171 dimer interface [polypeptide binding]; other site 1283330002172 active site 1283330002173 metal binding site [ion binding]; metal-binding site 1283330002174 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1283330002175 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1283330002176 NAD(P) binding site [chemical binding]; other site 1283330002177 catalytic residues [active] 1283330002178 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1283330002179 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330002180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330002181 Walker A motif; other site 1283330002182 ATP binding site [chemical binding]; other site 1283330002183 Walker B motif; other site 1283330002184 arginine finger; other site 1283330002185 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330002186 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1283330002187 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1283330002188 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1283330002189 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1283330002190 aromatic acid decarboxylase; Validated; Region: PRK05920 1283330002191 Flavoprotein; Region: Flavoprotein; pfam02441 1283330002192 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 1283330002193 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1283330002194 TolR protein; Region: tolR; TIGR02801 1283330002195 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1283330002196 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1283330002197 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1283330002198 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283330002199 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283330002200 Walker A/P-loop; other site 1283330002201 ATP binding site [chemical binding]; other site 1283330002202 Q-loop/lid; other site 1283330002203 ABC transporter signature motif; other site 1283330002204 Walker B; other site 1283330002205 D-loop; other site 1283330002206 H-loop/switch region; other site 1283330002207 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283330002208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1283330002209 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283330002210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1283330002211 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283330002212 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1283330002213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330002214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330002215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283330002216 dimerization interface [polypeptide binding]; other site 1283330002217 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1283330002218 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330002219 N-terminal plug; other site 1283330002220 ligand-binding site [chemical binding]; other site 1283330002221 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1283330002222 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1283330002223 active site 1283330002224 iron coordination sites [ion binding]; other site 1283330002225 substrate binding pocket [chemical binding]; other site 1283330002226 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1283330002227 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1283330002228 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330002229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330002230 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1283330002231 dimerization interface [polypeptide binding]; other site 1283330002232 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1283330002233 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330002234 N-terminal plug; other site 1283330002235 ligand-binding site [chemical binding]; other site 1283330002236 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1283330002237 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1283330002238 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1283330002239 Cache domain; Region: Cache_1; pfam02743 1283330002240 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330002241 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330002242 metal binding site [ion binding]; metal-binding site 1283330002243 active site 1283330002244 I-site; other site 1283330002245 FtsH Extracellular; Region: FtsH_ext; pfam06480 1283330002246 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1283330002247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330002248 Walker A motif; other site 1283330002249 ATP binding site [chemical binding]; other site 1283330002250 Walker B motif; other site 1283330002251 arginine finger; other site 1283330002252 Peptidase family M41; Region: Peptidase_M41; pfam01434 1283330002253 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1283330002254 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1283330002255 NAD binding site [chemical binding]; other site 1283330002256 active site 1283330002257 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1283330002258 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1283330002259 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1283330002260 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1283330002261 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1283330002262 Ca binding site [ion binding]; other site 1283330002263 active site 1283330002264 catalytic site [active] 1283330002265 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1283330002266 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1283330002267 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1283330002268 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1283330002269 active site 1283330002270 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1283330002271 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1283330002272 putative catalytic cysteine [active] 1283330002273 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1283330002274 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1283330002275 active site 1283330002276 (T/H)XGH motif; other site 1283330002277 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1283330002278 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1283330002279 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1283330002280 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1283330002281 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1283330002282 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1283330002283 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1283330002284 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1283330002285 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1283330002286 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1283330002287 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1283330002288 Sporulation related domain; Region: SPOR; pfam05036 1283330002289 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1283330002290 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1283330002291 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1283330002292 hypothetical protein; Provisional; Region: PRK00341 1283330002293 lipoate-protein ligase B; Provisional; Region: PRK14342 1283330002294 lipoyl synthase; Provisional; Region: PRK05481 1283330002295 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283330002296 FeS/SAM binding site; other site 1283330002297 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1283330002298 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1283330002299 PYR/PP interface [polypeptide binding]; other site 1283330002300 dimer interface [polypeptide binding]; other site 1283330002301 tetramer interface [polypeptide binding]; other site 1283330002302 TPP binding site [chemical binding]; other site 1283330002303 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1283330002304 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1283330002305 TPP-binding site [chemical binding]; other site 1283330002306 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1283330002307 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1283330002308 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1283330002309 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1283330002310 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1283330002311 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1283330002312 carboxyltransferase (CT) interaction site; other site 1283330002313 biotinylation site [posttranslational modification]; other site 1283330002314 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283330002315 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1283330002316 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1283330002317 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330002318 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the chlorocatechol catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_Chlorocatechol; cd08446 1283330002319 dimerization interface [polypeptide binding]; other site 1283330002320 putative substrate binding pocket [chemical binding]; other site 1283330002321 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1283330002322 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1283330002323 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 1283330002324 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 1283330002325 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 1283330002326 putative alpha subunit interface [polypeptide binding]; other site 1283330002327 putative active site [active] 1283330002328 putative substrate binding site [chemical binding]; other site 1283330002329 Fe binding site [ion binding]; other site 1283330002330 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1283330002331 inter-subunit interface; other site 1283330002332 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 1283330002333 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283330002334 catalytic loop [active] 1283330002335 iron binding site [ion binding]; other site 1283330002336 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 1283330002337 FAD binding pocket [chemical binding]; other site 1283330002338 FAD binding motif [chemical binding]; other site 1283330002339 phosphate binding motif [ion binding]; other site 1283330002340 beta-alpha-beta structure motif; other site 1283330002341 NAD binding pocket [chemical binding]; other site 1283330002342 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 1283330002343 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 1283330002344 putative NAD(P) binding site [chemical binding]; other site 1283330002345 active site 1283330002346 benzoate transport; Region: 2A0115; TIGR00895 1283330002347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330002348 putative substrate translocation pore; other site 1283330002349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330002350 putative substrate translocation pore; other site 1283330002351 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330002352 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1283330002353 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1283330002354 hexamer interface [polypeptide binding]; other site 1283330002355 Tautomerase enzyme; Region: Tautomerase; pfam01361 1283330002356 dimer interface [polypeptide binding]; other site 1283330002357 active site 2 [active] 1283330002358 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1283330002359 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1283330002360 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1283330002361 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283330002362 catalytic loop [active] 1283330002363 iron binding site [ion binding]; other site 1283330002364 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1283330002365 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 1283330002366 tetramer interface [polypeptide binding]; other site 1283330002367 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 1283330002368 tetramer interface [polypeptide binding]; other site 1283330002369 active site 1283330002370 Fe binding site [ion binding]; other site 1283330002371 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 1283330002372 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1283330002373 NAD binding site [chemical binding]; other site 1283330002374 catalytic residues [active] 1283330002375 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1283330002376 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1283330002377 active site 1283330002378 catalytic residues [active] 1283330002379 metal binding site [ion binding]; metal-binding site 1283330002380 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1283330002381 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1283330002382 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1283330002383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330002384 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 1283330002385 dimerizarion interface [polypeptide binding]; other site 1283330002386 CrgA pocket; other site 1283330002387 substrate binding pocket [chemical binding]; other site 1283330002388 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1283330002389 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1283330002390 active site 1 [active] 1283330002391 dimer interface [polypeptide binding]; other site 1283330002392 hexamer interface [polypeptide binding]; other site 1283330002393 active site 2 [active] 1283330002394 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1283330002395 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 1283330002396 tetramer interface [polypeptide binding]; other site 1283330002397 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1283330002398 active site 1283330002399 metal binding site [ion binding]; metal-binding site 1283330002400 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1283330002401 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283330002402 catalytic loop [active] 1283330002403 iron binding site [ion binding]; other site 1283330002404 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 1283330002405 FAD binding pocket [chemical binding]; other site 1283330002406 FAD binding motif [chemical binding]; other site 1283330002407 phosphate binding motif [ion binding]; other site 1283330002408 beta-alpha-beta structure motif; other site 1283330002409 NAD binding pocket [chemical binding]; other site 1283330002410 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 1283330002411 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 1283330002412 dimerization interface [polypeptide binding]; other site 1283330002413 putative path to active site cavity [active] 1283330002414 diiron center [ion binding]; other site 1283330002415 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 1283330002416 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 1283330002417 dimerization interface [polypeptide binding]; other site 1283330002418 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 1283330002419 Activator of aromatic catabolism; Region: XylR_N; pfam06505 1283330002420 V4R domain; Region: V4R; pfam02830 1283330002421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330002422 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1283330002423 Walker A motif; other site 1283330002424 ATP binding site [chemical binding]; other site 1283330002425 Walker B motif; other site 1283330002426 arginine finger; other site 1283330002427 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330002428 Putative addiction module component; Region: Unstab_antitox; cl09921 1283330002429 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1283330002430 Domain of unknown function; Region: DUF331; cl01149 1283330002431 Staphylococcal nuclease homologues; Region: SNc; smart00318 1283330002432 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1283330002433 Catalytic site; other site 1283330002434 Domain of unknown function; Region: DUF331; cl01149 1283330002435 YfbU domain; Region: YfbU; cl01137 1283330002436 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1283330002437 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1283330002438 Lipopolysaccharide-assembly; Region: LptE; cl01125 1283330002439 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1283330002440 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1283330002441 HIGH motif; other site 1283330002442 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1283330002443 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1283330002444 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1283330002445 active site 1283330002446 KMSKS motif; other site 1283330002447 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1283330002448 tRNA binding surface [nucleotide binding]; other site 1283330002449 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1283330002450 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1283330002451 putative active site [active] 1283330002452 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1283330002453 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1283330002454 putative active site [active] 1283330002455 catalytic triad [active] 1283330002456 putative dimer interface [polypeptide binding]; other site 1283330002457 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1283330002458 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1283330002459 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1283330002460 metal-binding heat shock protein; Provisional; Region: PRK00016 1283330002461 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1283330002462 PhoH-like protein; Region: PhoH; pfam02562 1283330002463 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1283330002464 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1283330002465 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283330002466 FeS/SAM binding site; other site 1283330002467 TRAM domain; Region: TRAM; pfam01938 1283330002468 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283330002469 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330002470 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330002471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1283330002472 Integrase core domain; Region: rve; pfam00665 1283330002473 Integrase core domain; Region: rve_3; pfam13683 1283330002474 Domain of unknown function (DUF1820); Region: DUF1820; pfam08850 1283330002475 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1283330002476 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330002477 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283330002478 dimerization interface [polypeptide binding]; other site 1283330002479 Domain of unknown function (DUF718); Region: DUF718; pfam05336 1283330002480 rhamnose-proton symporter; Provisional; Region: PRK13499 1283330002481 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1283330002482 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1283330002483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330002484 NAD(P) binding site [chemical binding]; other site 1283330002485 active site 1283330002486 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1283330002487 Amidohydrolase; Region: Amidohydro_2; pfam04909 1283330002488 active site 1283330002489 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283330002490 trimer interface; other site 1283330002491 sugar binding site [chemical binding]; other site 1283330002492 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1283330002493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330002494 putative substrate translocation pore; other site 1283330002495 L-rhamnonate dehydratase; Provisional; Region: PRK15440 1283330002496 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 1283330002497 putative active site pocket [active] 1283330002498 putative metal binding site [ion binding]; other site 1283330002499 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 1283330002500 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1283330002501 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1283330002502 NAD binding site [chemical binding]; other site 1283330002503 catalytic residues [active] 1283330002504 substrate binding site [chemical binding]; other site 1283330002505 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1283330002506 Sel1-like repeats; Region: SEL1; smart00671 1283330002507 Sel1-like repeats; Region: SEL1; smart00671 1283330002508 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1283330002509 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1283330002510 inhibitor-cofactor binding pocket; inhibition site 1283330002511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330002512 catalytic residue [active] 1283330002513 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1283330002514 thiamine phosphate binding site [chemical binding]; other site 1283330002515 active site 1283330002516 pyrophosphate binding site [ion binding]; other site 1283330002517 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1283330002518 dimer interface [polypeptide binding]; other site 1283330002519 substrate binding site [chemical binding]; other site 1283330002520 ATP binding site [chemical binding]; other site 1283330002521 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1283330002522 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283330002523 active site 1283330002524 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 1283330002525 dimer interface [polypeptide binding]; other site 1283330002526 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 1283330002527 active site 1283330002528 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1283330002529 catalytic residues [active] 1283330002530 substrate binding site [chemical binding]; other site 1283330002531 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1283330002532 IucA / IucC family; Region: IucA_IucC; pfam04183 1283330002533 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1283330002534 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1283330002535 IucA / IucC family; Region: IucA_IucC; pfam04183 1283330002536 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1283330002537 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1283330002538 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1283330002539 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330002540 N-terminal plug; other site 1283330002541 ligand-binding site [chemical binding]; other site 1283330002542 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1283330002543 AMP nucleosidase; Provisional; Region: PRK08292 1283330002544 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1283330002545 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1283330002546 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283330002547 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1283330002548 UreF; Region: UreF; pfam01730 1283330002549 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1283330002550 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1283330002551 dimer interface [polypeptide binding]; other site 1283330002552 catalytic residues [active] 1283330002553 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283330002554 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1283330002555 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1283330002556 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1283330002557 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1283330002558 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1283330002559 transcriptional activator TtdR; Provisional; Region: PRK09801 1283330002560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330002561 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1283330002562 putative effector binding pocket; other site 1283330002563 putative dimerization interface [polypeptide binding]; other site 1283330002564 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283330002565 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330002566 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1283330002567 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1283330002568 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 1283330002569 DNA binding site [nucleotide binding] 1283330002570 DNA-binding interface [nucleotide binding]; DNA binding site 1283330002571 domain linker motif; other site 1283330002572 Integrase core domain; Region: rve; pfam00665 1283330002573 transposase/IS protein; Provisional; Region: PRK09183 1283330002574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330002575 Walker A motif; other site 1283330002576 ATP binding site [chemical binding]; other site 1283330002577 Walker B motif; other site 1283330002578 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330002579 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330002580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283330002581 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283330002582 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283330002583 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283330002584 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283330002585 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1283330002586 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283330002587 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1283330002588 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283330002589 Protein of unknown function (DUF2976); Region: DUF2976; cl12739 1283330002590 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1283330002591 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283330002592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330002593 Walker A/P-loop; other site 1283330002594 ATP binding site [chemical binding]; other site 1283330002595 Q-loop/lid; other site 1283330002596 ABC transporter signature motif; other site 1283330002597 Walker B; other site 1283330002598 D-loop; other site 1283330002599 H-loop/switch region; other site 1283330002600 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1283330002601 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1283330002602 catalytic residues [active] 1283330002603 hinge region; other site 1283330002604 alpha helical domain; other site 1283330002605 Condensation domain; Region: Condensation; pfam00668 1283330002606 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283330002607 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1283330002608 acyl-activating enzyme (AAE) consensus motif; other site 1283330002609 AMP binding site [chemical binding]; other site 1283330002610 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330002611 Condensation domain; Region: Condensation; pfam00668 1283330002612 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1283330002613 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283330002614 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1283330002615 acyl-activating enzyme (AAE) consensus motif; other site 1283330002616 AMP binding site [chemical binding]; other site 1283330002617 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330002618 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1283330002619 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1283330002620 active site 1283330002621 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1283330002622 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283330002623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330002624 Walker A/P-loop; other site 1283330002625 ATP binding site [chemical binding]; other site 1283330002626 Q-loop/lid; other site 1283330002627 ABC transporter signature motif; other site 1283330002628 Walker B; other site 1283330002629 D-loop; other site 1283330002630 H-loop/switch region; other site 1283330002631 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1283330002632 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1283330002633 catalytic residues [active] 1283330002634 hinge region; other site 1283330002635 alpha helical domain; other site 1283330002636 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1283330002637 putative transposase OrfB; Reviewed; Region: PHA02517 1283330002638 HTH-like domain; Region: HTH_21; pfam13276 1283330002639 Integrase core domain; Region: rve; pfam00665 1283330002640 Integrase core domain; Region: rve_3; pfam13683 1283330002641 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283330002642 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283330002643 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283330002644 Transposase; Region: HTH_Tnp_1; cl17663 1283330002645 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283330002646 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1283330002647 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1283330002648 hypothetical protein; Provisional; Region: PRK14812 1283330002649 substrate binding site [chemical binding]; other site 1283330002650 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1283330002651 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1283330002652 substrate binding site [chemical binding]; other site 1283330002653 ligand binding site [chemical binding]; other site 1283330002654 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1283330002655 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1283330002656 tellurite resistance protein terB; Region: terB; cd07176 1283330002657 putative metal binding site [ion binding]; other site 1283330002658 Predicted integral membrane protein [Function unknown]; Region: COG0392 1283330002659 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1283330002660 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1283330002661 subunit interactions [polypeptide binding]; other site 1283330002662 active site 1283330002663 flap region; other site 1283330002664 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1283330002665 gamma-beta subunit interface [polypeptide binding]; other site 1283330002666 alpha-beta subunit interface [polypeptide binding]; other site 1283330002667 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1283330002668 alpha-gamma subunit interface [polypeptide binding]; other site 1283330002669 beta-gamma subunit interface [polypeptide binding]; other site 1283330002670 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 1283330002671 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1283330002672 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1283330002673 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1283330002674 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1283330002675 pseudouridine synthase; Region: TIGR00093 1283330002676 active site 1283330002677 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 1283330002678 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1283330002679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283330002680 dimerization interface [polypeptide binding]; other site 1283330002681 putative DNA binding site [nucleotide binding]; other site 1283330002682 putative Zn2+ binding site [ion binding]; other site 1283330002683 AsnC family; Region: AsnC_trans_reg; pfam01037 1283330002684 Cation efflux family; Region: Cation_efflux; cl00316 1283330002685 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1283330002686 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1283330002687 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283330002688 ATP binding site [chemical binding]; other site 1283330002689 putative Mg++ binding site [ion binding]; other site 1283330002690 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283330002691 nucleotide binding region [chemical binding]; other site 1283330002692 ATP-binding site [chemical binding]; other site 1283330002693 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1283330002694 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1283330002695 short chain dehydrogenase; Provisional; Region: PRK06181 1283330002696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330002697 NAD(P) binding site [chemical binding]; other site 1283330002698 active site 1283330002699 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1283330002700 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1283330002701 ATP binding site [chemical binding]; other site 1283330002702 Mg++ binding site [ion binding]; other site 1283330002703 motif III; other site 1283330002704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283330002705 nucleotide binding region [chemical binding]; other site 1283330002706 ATP-binding site [chemical binding]; other site 1283330002707 hypothetical protein; Provisional; Region: PRK07236 1283330002708 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 1283330002709 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1283330002710 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1283330002711 putative active site [active] 1283330002712 Zn binding site [ion binding]; other site 1283330002713 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1283330002714 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1283330002715 heme binding site [chemical binding]; other site 1283330002716 ferroxidase pore; other site 1283330002717 ferroxidase diiron center [ion binding]; other site 1283330002718 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1283330002719 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1283330002720 DNA binding residues [nucleotide binding] 1283330002721 dimer interface [polypeptide binding]; other site 1283330002722 copper binding site [ion binding]; other site 1283330002723 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1283330002724 metal-binding site [ion binding] 1283330002725 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1283330002726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283330002727 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1283330002728 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1283330002729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330002730 putative substrate translocation pore; other site 1283330002731 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1283330002732 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1283330002733 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1283330002734 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1283330002735 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1283330002736 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1283330002737 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1283330002738 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1283330002739 active site 1283330002740 nucleophile elbow; other site 1283330002741 selenophosphate synthetase; Provisional; Region: PRK00943 1283330002742 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1283330002743 dimerization interface [polypeptide binding]; other site 1283330002744 putative ATP binding site [chemical binding]; other site 1283330002745 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1283330002746 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1283330002747 active site residue [active] 1283330002748 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283330002749 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1283330002750 polyribonucleotide nucleotidyltransferase; Provisional; Region: PLN00207 1283330002751 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1283330002752 Haem-binding domain; Region: Haem_bd; pfam14376 1283330002753 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1283330002754 HopJ type III effector protein; Region: HopJ; pfam08888 1283330002755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 1283330002756 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1283330002757 homooctamer interface [polypeptide binding]; other site 1283330002758 active site 1283330002759 dihydromonapterin reductase; Provisional; Region: PRK06483 1283330002760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330002761 NAD(P) binding site [chemical binding]; other site 1283330002762 active site 1283330002763 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 1283330002764 Coenzyme A transferase; Region: CoA_trans; cl17247 1283330002765 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 1283330002766 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 1283330002767 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 1283330002768 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 1283330002769 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 1283330002770 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1283330002771 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 1283330002772 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1283330002773 Malonate transporter MadL subunit; Region: MadL; pfam03817 1283330002774 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 1283330002775 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1283330002776 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1283330002777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330002778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330002779 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 1283330002780 putative dimerization interface [polypeptide binding]; other site 1283330002781 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1283330002782 diiron binding motif [ion binding]; other site 1283330002783 Sulfatase; Region: Sulfatase; pfam00884 1283330002784 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1283330002785 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283330002786 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330002787 N-terminal plug; other site 1283330002788 ligand-binding site [chemical binding]; other site 1283330002789 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283330002790 FecR protein; Region: FecR; pfam04773 1283330002791 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1283330002792 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330002793 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330002794 DNA binding residues [nucleotide binding] 1283330002795 putative cation:proton antiport protein; Provisional; Region: PRK10669 1283330002796 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1283330002797 TrkA-N domain; Region: TrkA_N; pfam02254 1283330002798 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 1283330002799 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1283330002800 Ligand binding site [chemical binding]; other site 1283330002801 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1283330002802 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1283330002803 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1283330002804 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1283330002805 oxidoreductase; Provisional; Region: PRK10015 1283330002806 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283330002807 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1283330002808 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1283330002809 diiron binding motif [ion binding]; other site 1283330002810 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1283330002811 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1283330002812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330002813 active site 1283330002814 phosphorylation site [posttranslational modification] 1283330002815 intermolecular recognition site; other site 1283330002816 dimerization interface [polypeptide binding]; other site 1283330002817 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283330002818 DNA binding site [nucleotide binding] 1283330002819 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1283330002820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330002821 dimer interface [polypeptide binding]; other site 1283330002822 phosphorylation site [posttranslational modification] 1283330002823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330002824 ATP binding site [chemical binding]; other site 1283330002825 Mg2+ binding site [ion binding]; other site 1283330002826 G-X-G motif; other site 1283330002827 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1283330002828 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1283330002829 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1283330002830 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1283330002831 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1283330002832 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1283330002833 tonB-system energizer ExbB; Region: exbB; TIGR02797 1283330002834 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330002835 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1283330002836 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1283330002837 acyl-activating enzyme (AAE) consensus motif; other site 1283330002838 putative AMP binding site [chemical binding]; other site 1283330002839 putative active site [active] 1283330002840 putative CoA binding site [chemical binding]; other site 1283330002841 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330002842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330002843 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1283330002844 dimerization interface [polypeptide binding]; other site 1283330002845 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1283330002846 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283330002847 active site 1283330002848 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1283330002849 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283330002850 substrate binding site [chemical binding]; other site 1283330002851 oxyanion hole (OAH) forming residues; other site 1283330002852 trimer interface [polypeptide binding]; other site 1283330002853 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1283330002854 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1283330002855 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1283330002856 enoyl-CoA hydratase; Provisional; Region: PRK05862 1283330002857 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283330002858 substrate binding site [chemical binding]; other site 1283330002859 oxyanion hole (OAH) forming residues; other site 1283330002860 trimer interface [polypeptide binding]; other site 1283330002861 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1283330002862 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1283330002863 tetrameric interface [polypeptide binding]; other site 1283330002864 NAD binding site [chemical binding]; other site 1283330002865 catalytic residues [active] 1283330002866 transcriptional regulator; Provisional; Region: PRK10632 1283330002867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330002868 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283330002869 putative effector binding pocket; other site 1283330002870 dimerization interface [polypeptide binding]; other site 1283330002871 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1283330002872 B1 nucleotide binding pocket [chemical binding]; other site 1283330002873 B2 nucleotide binding pocket [chemical binding]; other site 1283330002874 CAS motifs; other site 1283330002875 active site 1283330002876 Uncharacterized conserved protein [Function unknown]; Region: COG2912 1283330002877 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1283330002878 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1283330002879 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1283330002880 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1283330002881 NAD binding site [chemical binding]; other site 1283330002882 Phe binding site; other site 1283330002883 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1283330002884 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1283330002885 TPP-binding site [chemical binding]; other site 1283330002886 tetramer interface [polypeptide binding]; other site 1283330002887 heterodimer interface [polypeptide binding]; other site 1283330002888 phosphorylation loop region [posttranslational modification] 1283330002889 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1283330002890 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1283330002891 alpha subunit interface [polypeptide binding]; other site 1283330002892 TPP binding site [chemical binding]; other site 1283330002893 heterodimer interface [polypeptide binding]; other site 1283330002894 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1283330002895 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1283330002896 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1283330002897 E3 interaction surface; other site 1283330002898 lipoyl attachment site [posttranslational modification]; other site 1283330002899 e3 binding domain; Region: E3_binding; pfam02817 1283330002900 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1283330002901 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1283330002902 Predicted membrane protein [Function unknown]; Region: COG3223 1283330002903 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1283330002904 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283330002905 ATP binding site [chemical binding]; other site 1283330002906 putative Mg++ binding site [ion binding]; other site 1283330002907 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283330002908 nucleotide binding region [chemical binding]; other site 1283330002909 ATP-binding site [chemical binding]; other site 1283330002910 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283330002911 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283330002912 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1283330002913 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1283330002914 Substrate binding site; other site 1283330002915 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1283330002916 Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182 1283330002917 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1283330002918 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cd00244 1283330002919 active site 1283330002920 Right handed beta helix region; Region: Beta_helix; pfam13229 1283330002921 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1283330002922 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1283330002923 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1283330002924 Sel1-like repeats; Region: SEL1; smart00671 1283330002925 Sel1-like repeats; Region: SEL1; smart00671 1283330002926 PilZ domain; Region: PilZ; pfam07238 1283330002927 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283330002928 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1283330002929 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1283330002930 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1283330002931 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1283330002932 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1283330002933 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1283330002934 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1283330002935 Small hydrophilic plant seed protein; Region: LEA_5; pfam00477 1283330002936 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1283330002937 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1283330002938 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1283330002939 Predicted membrane protein [Function unknown]; Region: COG2323 1283330002940 short chain dehydrogenase; Provisional; Region: PRK06701 1283330002941 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1283330002942 NAD binding site [chemical binding]; other site 1283330002943 metal binding site [ion binding]; metal-binding site 1283330002944 active site 1283330002945 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1283330002946 dinuclear metal binding motif [ion binding]; other site 1283330002947 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1283330002948 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1283330002949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330002950 active site 1283330002951 phosphorylation site [posttranslational modification] 1283330002952 intermolecular recognition site; other site 1283330002953 dimerization interface [polypeptide binding]; other site 1283330002954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330002955 Walker A motif; other site 1283330002956 ATP binding site [chemical binding]; other site 1283330002957 Walker B motif; other site 1283330002958 arginine finger; other site 1283330002959 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330002960 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 1283330002961 Predicted membrane protein [Function unknown]; Region: COG4244 1283330002962 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1283330002963 Cytochrome c; Region: Cytochrom_C; cl11414 1283330002964 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1283330002965 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1283330002966 D-pathway; other site 1283330002967 Putative ubiquinol binding site [chemical binding]; other site 1283330002968 Low-spin heme (heme b) binding site [chemical binding]; other site 1283330002969 Putative water exit pathway; other site 1283330002970 Binuclear center (heme o3/CuB) [ion binding]; other site 1283330002971 K-pathway; other site 1283330002972 Putative proton exit pathway; other site 1283330002973 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1283330002974 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1283330002975 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1283330002976 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1283330002977 active site 1283330002978 hypothetical protein; Validated; Region: PRK02101 1283330002979 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1283330002980 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1283330002981 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1283330002982 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1283330002983 putative active site [active] 1283330002984 PhoH-like protein; Region: PhoH; pfam02562 1283330002985 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1283330002986 trimer interface [polypeptide binding]; other site 1283330002987 dimer interface [polypeptide binding]; other site 1283330002988 putative active site [active] 1283330002989 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1283330002990 MoaE interaction surface [polypeptide binding]; other site 1283330002991 MoeB interaction surface [polypeptide binding]; other site 1283330002992 thiocarboxylated glycine; other site 1283330002993 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1283330002994 MoaD interaction [polypeptide binding]; other site 1283330002995 active site residues [active] 1283330002996 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 1283330002997 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1283330002998 ATP binding site [chemical binding]; other site 1283330002999 Mg++ binding site [ion binding]; other site 1283330003000 motif III; other site 1283330003001 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283330003002 nucleotide binding region [chemical binding]; other site 1283330003003 ATP-binding site [chemical binding]; other site 1283330003004 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1283330003005 putative hydrolase; Provisional; Region: PRK11460 1283330003006 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283330003007 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330003008 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330003009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1283330003010 Integrase core domain; Region: rve; pfam00665 1283330003011 Integrase core domain; Region: rve_3; pfam13683 1283330003012 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330003013 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1283330003014 GIY-YIG motif/motif A; other site 1283330003015 putative active site [active] 1283330003016 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1283330003017 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1283330003018 C-terminal domain interface [polypeptide binding]; other site 1283330003019 GSH binding site (G-site) [chemical binding]; other site 1283330003020 dimer interface [polypeptide binding]; other site 1283330003021 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1283330003022 N-terminal domain interface [polypeptide binding]; other site 1283330003023 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1283330003024 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1283330003025 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1283330003026 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1283330003027 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 1283330003028 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 1283330003029 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1283330003030 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1283330003031 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1283330003032 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1283330003033 GAF domain; Region: GAF; pfam01590 1283330003034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330003035 Walker A motif; other site 1283330003036 ATP binding site [chemical binding]; other site 1283330003037 Walker B motif; other site 1283330003038 arginine finger; other site 1283330003039 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330003040 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1283330003041 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283330003042 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1283330003043 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1283330003044 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1283330003045 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1283330003046 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1283330003047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330003048 motif II; other site 1283330003049 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1283330003050 transcriptional regulator; Provisional; Region: PRK10632 1283330003051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330003052 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283330003053 putative effector binding pocket; other site 1283330003054 dimerization interface [polypeptide binding]; other site 1283330003055 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1283330003056 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1283330003057 putative active site [active] 1283330003058 metal binding site [ion binding]; metal-binding site 1283330003059 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1283330003060 classical (c) SDRs; Region: SDR_c; cd05233 1283330003061 NAD(P) binding site [chemical binding]; other site 1283330003062 active site 1283330003063 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 1283330003064 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1283330003065 exonuclease subunit SbcD; Provisional; Region: PRK10966 1283330003066 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1283330003067 active site 1283330003068 metal binding site [ion binding]; metal-binding site 1283330003069 DNA binding site [nucleotide binding] 1283330003070 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1283330003071 exonuclease subunit SbcC; Provisional; Region: PRK10246 1283330003072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330003073 Walker A/P-loop; other site 1283330003074 ATP binding site [chemical binding]; other site 1283330003075 Q-loop/lid; other site 1283330003076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330003077 ABC transporter signature motif; other site 1283330003078 Walker B; other site 1283330003079 D-loop; other site 1283330003080 H-loop/switch region; other site 1283330003081 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1283330003082 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1283330003083 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1283330003084 Transporter associated domain; Region: CorC_HlyC; smart01091 1283330003085 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1283330003086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330003087 S-adenosylmethionine binding site [chemical binding]; other site 1283330003088 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330003089 PAS domain; Region: PAS_9; pfam13426 1283330003090 putative active site [active] 1283330003091 heme pocket [chemical binding]; other site 1283330003092 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330003093 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330003094 metal binding site [ion binding]; metal-binding site 1283330003095 active site 1283330003096 I-site; other site 1283330003097 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283330003098 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1283330003099 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1283330003100 HIGH motif; other site 1283330003101 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1283330003102 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1283330003103 active site 1283330003104 KMSKS motif; other site 1283330003105 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1283330003106 tRNA binding surface [nucleotide binding]; other site 1283330003107 anticodon binding site; other site 1283330003108 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1283330003109 DNA polymerase III subunit chi; Validated; Region: PRK05728 1283330003110 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1283330003111 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1283330003112 interface (dimer of trimers) [polypeptide binding]; other site 1283330003113 Substrate-binding/catalytic site; other site 1283330003114 Zn-binding sites [ion binding]; other site 1283330003115 Predicted permeases [General function prediction only]; Region: COG0795 1283330003116 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1283330003117 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1283330003118 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1283330003119 RDD family; Region: RDD; pfam06271 1283330003120 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1283330003121 DNA-binding site [nucleotide binding]; DNA binding site 1283330003122 RNA-binding motif; other site 1283330003123 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1283330003124 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1283330003125 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1283330003126 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1283330003127 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1283330003128 Riboflavin kinase; Region: Flavokinase; smart00904 1283330003129 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1283330003130 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1283330003131 active site 1283330003132 HIGH motif; other site 1283330003133 nucleotide binding site [chemical binding]; other site 1283330003134 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1283330003135 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1283330003136 active site 1283330003137 KMSKS motif; other site 1283330003138 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1283330003139 tRNA binding surface [nucleotide binding]; other site 1283330003140 anticodon binding site; other site 1283330003141 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1283330003142 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1283330003143 lipoprotein signal peptidase; Provisional; Region: PRK14787 1283330003144 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1283330003145 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1283330003146 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1283330003147 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1283330003148 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1283330003149 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1283330003150 Type II transport protein GspH; Region: GspH; pfam12019 1283330003151 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 1283330003152 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1283330003153 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 1283330003154 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 1283330003155 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1283330003156 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1283330003157 NAD synthetase; Provisional; Region: PRK13981 1283330003158 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1283330003159 multimer interface [polypeptide binding]; other site 1283330003160 active site 1283330003161 catalytic triad [active] 1283330003162 protein interface 1 [polypeptide binding]; other site 1283330003163 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1283330003164 homodimer interface [polypeptide binding]; other site 1283330003165 NAD binding pocket [chemical binding]; other site 1283330003166 ATP binding pocket [chemical binding]; other site 1283330003167 Mg binding site [ion binding]; other site 1283330003168 active-site loop [active] 1283330003169 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1283330003170 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1283330003171 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1283330003172 RNA binding surface [nucleotide binding]; other site 1283330003173 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1283330003174 active site 1283330003175 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1283330003176 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1283330003177 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1283330003178 Clp amino terminal domain; Region: Clp_N; pfam02861 1283330003179 Clp amino terminal domain; Region: Clp_N; pfam02861 1283330003180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330003181 Walker A motif; other site 1283330003182 ATP binding site [chemical binding]; other site 1283330003183 Walker B motif; other site 1283330003184 arginine finger; other site 1283330003185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330003186 Walker A motif; other site 1283330003187 ATP binding site [chemical binding]; other site 1283330003188 Walker B motif; other site 1283330003189 arginine finger; other site 1283330003190 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1283330003191 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1283330003192 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283330003193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330003194 Walker A/P-loop; other site 1283330003195 ATP binding site [chemical binding]; other site 1283330003196 Q-loop/lid; other site 1283330003197 ABC transporter signature motif; other site 1283330003198 Walker B; other site 1283330003199 D-loop; other site 1283330003200 H-loop/switch region; other site 1283330003201 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1283330003202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283330003203 Protein of unknown function (DUF3094); Region: DUF3094; pfam11293 1283330003204 putative acetyltransferase; Provisional; Region: PRK03624 1283330003205 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1283330003206 Coenzyme A binding pocket [chemical binding]; other site 1283330003207 Predicted membrane protein [Function unknown]; Region: COG3235 1283330003208 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1283330003209 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1283330003210 CoA-binding site [chemical binding]; other site 1283330003211 ATP-binding [chemical binding]; other site 1283330003212 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1283330003213 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1283330003214 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1283330003215 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1283330003216 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1283330003217 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1283330003218 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1283330003219 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1283330003220 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1283330003221 Walker A motif; other site 1283330003222 ATP binding site [chemical binding]; other site 1283330003223 Walker B motif; other site 1283330003224 Pilin (bacterial filament); Region: Pilin; pfam00114 1283330003225 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK05742 1283330003226 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1283330003227 dimerization interface [polypeptide binding]; other site 1283330003228 active site 1283330003229 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1283330003230 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1283330003231 amidase catalytic site [active] 1283330003232 Zn binding residues [ion binding]; other site 1283330003233 substrate binding site [chemical binding]; other site 1283330003234 Membrane protein required for beta-lactamase induction [Defense mechanisms]; Region: AmpE; cl17896 1283330003235 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1283330003236 active site 1283330003237 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1283330003238 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1283330003239 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1283330003240 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1283330003241 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1283330003242 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1283330003243 putative active site [active] 1283330003244 putative metal binding site [ion binding]; other site 1283330003245 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1283330003246 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1283330003247 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283330003248 DNA binding site [nucleotide binding] 1283330003249 domain linker motif; other site 1283330003250 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1283330003251 dimerization interface [polypeptide binding]; other site 1283330003252 ligand binding site [chemical binding]; other site 1283330003253 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1283330003254 active site 1283330003255 phosphorylation site [posttranslational modification] 1283330003256 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1283330003257 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1283330003258 dimerization domain swap beta strand [polypeptide binding]; other site 1283330003259 regulatory protein interface [polypeptide binding]; other site 1283330003260 active site 1283330003261 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1283330003262 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1283330003263 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1283330003264 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1283330003265 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1283330003266 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1283330003267 putative substrate binding site [chemical binding]; other site 1283330003268 putative ATP binding site [chemical binding]; other site 1283330003269 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1283330003270 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1283330003271 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1283330003272 active site 1283330003273 P-loop; other site 1283330003274 phosphorylation site [posttranslational modification] 1283330003275 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1283330003276 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1283330003277 classical (c) SDRs; Region: SDR_c; cd05233 1283330003278 NAD(P) binding site [chemical binding]; other site 1283330003279 active site 1283330003280 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1283330003281 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1283330003282 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1283330003283 G1 box; other site 1283330003284 putative GEF interaction site [polypeptide binding]; other site 1283330003285 GTP/Mg2+ binding site [chemical binding]; other site 1283330003286 Switch I region; other site 1283330003287 G2 box; other site 1283330003288 G3 box; other site 1283330003289 Switch II region; other site 1283330003290 G4 box; other site 1283330003291 G5 box; other site 1283330003292 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1283330003293 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1283330003294 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1283330003295 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1283330003296 Surface antigen; Region: Bac_surface_Ag; pfam01103 1283330003297 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1283330003298 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 1283330003299 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 1283330003300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330003301 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1283330003302 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330003303 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1283330003304 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1283330003305 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1283330003306 dimer interface [polypeptide binding]; other site 1283330003307 active site 1283330003308 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1283330003309 catalytic residues [active] 1283330003310 substrate binding site [chemical binding]; other site 1283330003311 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1283330003312 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330003313 N-terminal plug; other site 1283330003314 ligand-binding site [chemical binding]; other site 1283330003315 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1283330003316 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1283330003317 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1283330003318 active site 1283330003319 substrate binding site [chemical binding]; other site 1283330003320 FMN binding site [chemical binding]; other site 1283330003321 putative catalytic residues [active] 1283330003322 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1283330003323 Flavodoxin; Region: Flavodoxin_1; pfam00258 1283330003324 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1283330003325 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 1283330003326 FAD binding pocket [chemical binding]; other site 1283330003327 FAD binding motif [chemical binding]; other site 1283330003328 catalytic residues [active] 1283330003329 NAD binding pocket [chemical binding]; other site 1283330003330 phosphate binding motif [ion binding]; other site 1283330003331 beta-alpha-beta structure motif; other site 1283330003332 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1283330003333 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 1283330003334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 1283330003335 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1283330003336 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1283330003337 Sel1-like repeats; Region: SEL1; smart00671 1283330003338 Sel1-like repeats; Region: SEL1; smart00671 1283330003339 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1283330003340 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1283330003341 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330003342 N-terminal plug; other site 1283330003343 ligand-binding site [chemical binding]; other site 1283330003344 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1283330003345 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1283330003346 Flavodoxin; Region: Flavodoxin_1; pfam00258 1283330003347 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like1; cd06200 1283330003348 FAD binding pocket [chemical binding]; other site 1283330003349 FAD binding motif [chemical binding]; other site 1283330003350 catalytic residues [active] 1283330003351 NAD binding pocket [chemical binding]; other site 1283330003352 phosphate binding motif [ion binding]; other site 1283330003353 beta-alpha-beta structure motif; other site 1283330003354 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1283330003355 putative active site [active] 1283330003356 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1283330003357 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1283330003358 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1283330003359 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1283330003360 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283330003361 Walker A/P-loop; other site 1283330003362 ATP binding site [chemical binding]; other site 1283330003363 Q-loop/lid; other site 1283330003364 ABC transporter signature motif; other site 1283330003365 Walker B; other site 1283330003366 D-loop; other site 1283330003367 H-loop/switch region; other site 1283330003368 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1283330003369 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1283330003370 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283330003371 Walker A/P-loop; other site 1283330003372 ATP binding site [chemical binding]; other site 1283330003373 Q-loop/lid; other site 1283330003374 ABC transporter signature motif; other site 1283330003375 Walker B; other site 1283330003376 D-loop; other site 1283330003377 H-loop/switch region; other site 1283330003378 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1283330003379 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1283330003380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1283330003381 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1283330003382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330003383 dimer interface [polypeptide binding]; other site 1283330003384 conserved gate region; other site 1283330003385 putative PBP binding loops; other site 1283330003386 ABC-ATPase subunit interface; other site 1283330003387 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1283330003388 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1283330003389 peptide binding site [polypeptide binding]; other site 1283330003390 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1283330003391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283330003392 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1283330003393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330003394 active site 1283330003395 phosphorylation site [posttranslational modification] 1283330003396 intermolecular recognition site; other site 1283330003397 dimerization interface [polypeptide binding]; other site 1283330003398 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330003399 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1283330003400 Predicted permeases [General function prediction only]; Region: COG0679 1283330003401 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 1283330003402 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1283330003403 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1283330003404 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1283330003405 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1283330003406 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1283330003407 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1283330003408 GatB domain; Region: GatB_Yqey; smart00845 1283330003409 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1283330003410 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1283330003411 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1283330003412 rod shape-determining protein MreB; Provisional; Region: PRK13927 1283330003413 MreB and similar proteins; Region: MreB_like; cd10225 1283330003414 nucleotide binding site [chemical binding]; other site 1283330003415 Mg binding site [ion binding]; other site 1283330003416 putative protofilament interaction site [polypeptide binding]; other site 1283330003417 RodZ interaction site [polypeptide binding]; other site 1283330003418 rod shape-determining protein MreC; Provisional; Region: PRK13922 1283330003419 rod shape-determining protein MreC; Region: MreC; pfam04085 1283330003420 rod shape-determining protein MreD; Region: MreD; cl01087 1283330003421 Maf-like protein; Region: Maf; pfam02545 1283330003422 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1283330003423 active site 1283330003424 dimer interface [polypeptide binding]; other site 1283330003425 ribonuclease G; Provisional; Region: PRK11712 1283330003426 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1283330003427 homodimer interface [polypeptide binding]; other site 1283330003428 oligonucleotide binding site [chemical binding]; other site 1283330003429 TIGR02099 family protein; Region: TIGR02099 1283330003430 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1283330003431 nitrilase; Region: PLN02798 1283330003432 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1283330003433 putative active site [active] 1283330003434 catalytic triad [active] 1283330003435 dimer interface [polypeptide binding]; other site 1283330003436 hypothetical protein; Provisional; Region: PRK05255 1283330003437 peptidase PmbA; Provisional; Region: PRK11040 1283330003438 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1283330003439 dimerization domain swap beta strand [polypeptide binding]; other site 1283330003440 regulatory protein interface [polypeptide binding]; other site 1283330003441 active site 1283330003442 regulatory phosphorylation site [posttranslational modification]; other site 1283330003443 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1283330003444 AAA domain; Region: AAA_18; pfam13238 1283330003445 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1283330003446 active site 1283330003447 phosphorylation site [posttranslational modification] 1283330003448 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1283330003449 30S subunit binding site; other site 1283330003450 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1283330003451 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1283330003452 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1283330003453 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1283330003454 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1283330003455 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1283330003456 Walker A/P-loop; other site 1283330003457 ATP binding site [chemical binding]; other site 1283330003458 Q-loop/lid; other site 1283330003459 ABC transporter signature motif; other site 1283330003460 Walker B; other site 1283330003461 D-loop; other site 1283330003462 H-loop/switch region; other site 1283330003463 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1283330003464 OstA-like protein; Region: OstA; pfam03968 1283330003465 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1283330003466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 1283330003467 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1283330003468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330003469 active site 1283330003470 motif I; other site 1283330003471 motif II; other site 1283330003472 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1283330003473 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1283330003474 putative active site [active] 1283330003475 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1283330003476 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1283330003477 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1283330003478 Walker A/P-loop; other site 1283330003479 ATP binding site [chemical binding]; other site 1283330003480 Q-loop/lid; other site 1283330003481 ABC transporter signature motif; other site 1283330003482 Walker B; other site 1283330003483 D-loop; other site 1283330003484 H-loop/switch region; other site 1283330003485 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1283330003486 Permease; Region: Permease; cl00510 1283330003487 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1283330003488 mce related protein; Region: MCE; pfam02470 1283330003489 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1283330003490 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1283330003491 anti sigma factor interaction site; other site 1283330003492 regulatory phosphorylation site [posttranslational modification]; other site 1283330003493 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1283330003494 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1283330003495 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1283330003496 hinge; other site 1283330003497 active site 1283330003498 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1283330003499 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1283330003500 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1283330003501 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1283330003502 NAD binding site [chemical binding]; other site 1283330003503 dimerization interface [polypeptide binding]; other site 1283330003504 product binding site; other site 1283330003505 substrate binding site [chemical binding]; other site 1283330003506 zinc binding site [ion binding]; other site 1283330003507 catalytic residues [active] 1283330003508 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1283330003509 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283330003510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330003511 homodimer interface [polypeptide binding]; other site 1283330003512 catalytic residue [active] 1283330003513 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1283330003514 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1283330003515 protein binding site [polypeptide binding]; other site 1283330003516 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1283330003517 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1283330003518 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1283330003519 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1283330003520 Active Sites [active] 1283330003521 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1283330003522 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1283330003523 CysD dimerization site [polypeptide binding]; other site 1283330003524 G1 box; other site 1283330003525 putative GEF interaction site [polypeptide binding]; other site 1283330003526 GTP/Mg2+ binding site [chemical binding]; other site 1283330003527 Switch I region; other site 1283330003528 G2 box; other site 1283330003529 G3 box; other site 1283330003530 Switch II region; other site 1283330003531 G4 box; other site 1283330003532 G5 box; other site 1283330003533 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1283330003534 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1283330003535 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1283330003536 ligand-binding site [chemical binding]; other site 1283330003537 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 1283330003538 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1283330003539 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283330003540 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK12284 1283330003541 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1283330003542 active site 1283330003543 HIGH motif; other site 1283330003544 dimer interface [polypeptide binding]; other site 1283330003545 KMSKS motif; other site 1283330003546 Predicted ATPase [General function prediction only]; Region: COG1485 1283330003547 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1283330003548 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1283330003549 Active_site [active] 1283330003550 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1283330003551 23S rRNA interface [nucleotide binding]; other site 1283330003552 L3 interface [polypeptide binding]; other site 1283330003553 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1283330003554 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1283330003555 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1283330003556 [2Fe-2S] cluster binding site [ion binding]; other site 1283330003557 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1283330003558 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1283330003559 Qi binding site; other site 1283330003560 intrachain domain interface; other site 1283330003561 interchain domain interface [polypeptide binding]; other site 1283330003562 heme bH binding site [chemical binding]; other site 1283330003563 heme bL binding site [chemical binding]; other site 1283330003564 Qo binding site; other site 1283330003565 interchain domain interface [polypeptide binding]; other site 1283330003566 intrachain domain interface; other site 1283330003567 Qi binding site; other site 1283330003568 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 1283330003569 Qo binding site; other site 1283330003570 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1283330003571 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1283330003572 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1283330003573 C-terminal domain interface [polypeptide binding]; other site 1283330003574 putative GSH binding site (G-site) [chemical binding]; other site 1283330003575 dimer interface [polypeptide binding]; other site 1283330003576 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1283330003577 N-terminal domain interface [polypeptide binding]; other site 1283330003578 dimer interface [polypeptide binding]; other site 1283330003579 substrate binding pocket (H-site) [chemical binding]; other site 1283330003580 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1283330003581 BON domain; Region: BON; pfam04972 1283330003582 BON domain; Region: BON; cl02771 1283330003583 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1283330003584 dimer interface [polypeptide binding]; other site 1283330003585 active site 1283330003586 hypothetical protein; Reviewed; Region: PRK12497 1283330003587 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1283330003588 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1283330003589 putative ligand binding site [chemical binding]; other site 1283330003590 Predicted methyltransferases [General function prediction only]; Region: COG0313 1283330003591 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1283330003592 putative SAM binding site [chemical binding]; other site 1283330003593 putative homodimer interface [polypeptide binding]; other site 1283330003594 cell division protein MraZ; Reviewed; Region: PRK00326 1283330003595 MraZ protein; Region: MraZ; pfam02381 1283330003596 MraZ protein; Region: MraZ; pfam02381 1283330003597 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1283330003598 MraW methylase family; Region: Methyltransf_5; cl17771 1283330003599 Cell division protein FtsL; Region: FtsL; pfam04999 1283330003600 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1283330003601 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1283330003602 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1283330003603 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1283330003604 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1283330003605 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1283330003606 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1283330003607 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1283330003608 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1283330003609 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1283330003610 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1283330003611 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1283330003612 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1283330003613 Mg++ binding site [ion binding]; other site 1283330003614 putative catalytic motif [active] 1283330003615 putative substrate binding site [chemical binding]; other site 1283330003616 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03803 1283330003617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330003618 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1283330003619 cell division protein FtsW; Region: ftsW; TIGR02614 1283330003620 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1283330003621 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1283330003622 active site 1283330003623 homodimer interface [polypeptide binding]; other site 1283330003624 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1283330003625 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1283330003626 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1283330003627 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1283330003628 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1283330003629 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1283330003630 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1283330003631 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1283330003632 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1283330003633 Cell division protein FtsQ; Region: FtsQ; pfam03799 1283330003634 cell division protein FtsA; Region: ftsA; TIGR01174 1283330003635 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1283330003636 nucleotide binding site [chemical binding]; other site 1283330003637 Cell division protein FtsA; Region: FtsA; pfam14450 1283330003638 cell division protein FtsZ; Validated; Region: PRK09330 1283330003639 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1283330003640 nucleotide binding site [chemical binding]; other site 1283330003641 SulA interaction site; other site 1283330003642 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1283330003643 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1283330003644 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK13103 1283330003645 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1283330003646 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1283330003647 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1283330003648 nucleotide binding region [chemical binding]; other site 1283330003649 ATP-binding site [chemical binding]; other site 1283330003650 SEC-C motif; Region: SEC-C; pfam02810 1283330003651 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1283330003652 heterotetramer interface [polypeptide binding]; other site 1283330003653 active site pocket [active] 1283330003654 cleavage site 1283330003655 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1283330003656 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1283330003657 putative C-terminal domain interface [polypeptide binding]; other site 1283330003658 putative GSH binding site (G-site) [chemical binding]; other site 1283330003659 putative dimer interface [polypeptide binding]; other site 1283330003660 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1283330003661 putative N-terminal domain interface [polypeptide binding]; other site 1283330003662 putative dimer interface [polypeptide binding]; other site 1283330003663 putative substrate binding pocket (H-site) [chemical binding]; other site 1283330003664 hypothetical protein; Provisional; Region: PRK08999 1283330003665 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1283330003666 active site 1283330003667 8-oxo-dGMP binding site [chemical binding]; other site 1283330003668 nudix motif; other site 1283330003669 metal binding site [ion binding]; metal-binding site 1283330003670 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1283330003671 thiamine phosphate binding site [chemical binding]; other site 1283330003672 active site 1283330003673 pyrophosphate binding site [ion binding]; other site 1283330003674 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1283330003675 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1283330003676 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283330003677 dimerization interface [polypeptide binding]; other site 1283330003678 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1283330003679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330003680 putative active site [active] 1283330003681 heme pocket [chemical binding]; other site 1283330003682 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330003683 dimer interface [polypeptide binding]; other site 1283330003684 phosphorylation site [posttranslational modification] 1283330003685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330003686 ATP binding site [chemical binding]; other site 1283330003687 Mg2+ binding site [ion binding]; other site 1283330003688 G-X-G motif; other site 1283330003689 2-dehydropantoate 2-reductase; Provisional; Region: PRK05708 1283330003690 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1283330003691 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1283330003692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1283330003693 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1283330003694 muropeptide transporter; Validated; Region: ampG; cl17669 1283330003695 muropeptide transporter; Validated; Region: ampG; cl17669 1283330003696 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1283330003697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330003698 NAD(P) binding site [chemical binding]; other site 1283330003699 active site 1283330003700 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1283330003701 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 1283330003702 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1283330003703 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1283330003704 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1283330003705 oligomerisation interface [polypeptide binding]; other site 1283330003706 mobile loop; other site 1283330003707 roof hairpin; other site 1283330003708 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1283330003709 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1283330003710 ring oligomerisation interface [polypeptide binding]; other site 1283330003711 ATP/Mg binding site [chemical binding]; other site 1283330003712 stacking interactions; other site 1283330003713 hinge regions; other site 1283330003714 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1283330003715 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283330003716 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1283330003717 putative active site [active] 1283330003718 putative NTP binding site [chemical binding]; other site 1283330003719 putative nucleic acid binding site [nucleotide binding]; other site 1283330003720 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1283330003721 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1283330003722 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1283330003723 active site 1283330003724 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1283330003725 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1283330003726 active site 1283330003727 uracil binding [chemical binding]; other site 1283330003728 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330003729 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330003730 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330003731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330003732 enoyl-CoA hydratase; Provisional; Region: PRK09076 1283330003733 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283330003734 substrate binding site [chemical binding]; other site 1283330003735 oxyanion hole (OAH) forming residues; other site 1283330003736 trimer interface [polypeptide binding]; other site 1283330003737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283330003738 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283330003739 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283330003740 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330003741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330003742 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330003743 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330003744 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1283330003745 ligand binding site [chemical binding]; other site 1283330003746 active site 1283330003747 UGI interface [polypeptide binding]; other site 1283330003748 catalytic site [active] 1283330003749 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1283330003750 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1283330003751 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1283330003752 L-aspartate oxidase; Provisional; Region: PRK09077 1283330003753 L-aspartate oxidase; Provisional; Region: PRK06175 1283330003754 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1283330003755 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1283330003756 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1283330003757 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 1283330003758 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1283330003759 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1283330003760 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1283330003761 MucB/RseB family; Region: MucB_RseB; pfam03888 1283330003762 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 1283330003763 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1283330003764 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1283330003765 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1283330003766 protein binding site [polypeptide binding]; other site 1283330003767 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1283330003768 protein binding site [polypeptide binding]; other site 1283330003769 GTP-binding protein LepA; Provisional; Region: PRK05433 1283330003770 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1283330003771 G1 box; other site 1283330003772 putative GEF interaction site [polypeptide binding]; other site 1283330003773 GTP/Mg2+ binding site [chemical binding]; other site 1283330003774 Switch I region; other site 1283330003775 G2 box; other site 1283330003776 G3 box; other site 1283330003777 Switch II region; other site 1283330003778 G4 box; other site 1283330003779 G5 box; other site 1283330003780 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1283330003781 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1283330003782 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1283330003783 signal peptidase I; Provisional; Region: PRK10861 1283330003784 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1283330003785 Catalytic site [active] 1283330003786 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1283330003787 ribonuclease III; Reviewed; Region: rnc; PRK00102 1283330003788 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1283330003789 dimerization interface [polypeptide binding]; other site 1283330003790 active site 1283330003791 metal binding site [ion binding]; metal-binding site 1283330003792 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1283330003793 dsRNA binding site [nucleotide binding]; other site 1283330003794 GTPase Era; Reviewed; Region: era; PRK00089 1283330003795 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1283330003796 G1 box; other site 1283330003797 GTP/Mg2+ binding site [chemical binding]; other site 1283330003798 Switch I region; other site 1283330003799 G2 box; other site 1283330003800 Switch II region; other site 1283330003801 G3 box; other site 1283330003802 G4 box; other site 1283330003803 G5 box; other site 1283330003804 Alginate lyase; Region: Alginate_lyase2; pfam08787 1283330003805 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1283330003806 Recombination protein O N terminal; Region: RecO_N; pfam11967 1283330003807 Recombination protein O C terminal; Region: RecO_C; pfam02565 1283330003808 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1283330003809 active site 1283330003810 hydrophilic channel; other site 1283330003811 dimerization interface [polypeptide binding]; other site 1283330003812 catalytic residues [active] 1283330003813 active site lid [active] 1283330003814 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1283330003815 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1283330003816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330003817 S-adenosylmethionine binding site [chemical binding]; other site 1283330003818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330003819 S-adenosylmethionine binding site [chemical binding]; other site 1283330003820 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1283330003821 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1283330003822 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1283330003823 Bacterial transcriptional regulator; Region: IclR; pfam01614 1283330003824 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1283330003825 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1283330003826 tetrameric interface [polypeptide binding]; other site 1283330003827 NAD binding site [chemical binding]; other site 1283330003828 catalytic residues [active] 1283330003829 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1283330003830 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 1283330003831 putative active site [active] 1283330003832 metal binding site [ion binding]; metal-binding site 1283330003833 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1283330003834 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1283330003835 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1283330003836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330003837 Walker A motif; other site 1283330003838 ATP binding site [chemical binding]; other site 1283330003839 Walker B motif; other site 1283330003840 arginine finger; other site 1283330003841 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1283330003842 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1283330003843 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1283330003844 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 1283330003845 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1283330003846 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1283330003847 Glutamate binding site [chemical binding]; other site 1283330003848 NAD binding site [chemical binding]; other site 1283330003849 catalytic residues [active] 1283330003850 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1283330003851 Transglycosylase; Region: Transgly; cl17702 1283330003852 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1283330003853 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1283330003854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330003855 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1283330003856 putative dimerization interface [polypeptide binding]; other site 1283330003857 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1283330003858 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1283330003859 THF binding site; other site 1283330003860 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1283330003861 substrate binding site [chemical binding]; other site 1283330003862 THF binding site; other site 1283330003863 zinc-binding site [ion binding]; other site 1283330003864 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1283330003865 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1283330003866 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1283330003867 putative deacylase active site [active] 1283330003868 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1283330003869 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1283330003870 Walker A/P-loop; other site 1283330003871 ATP binding site [chemical binding]; other site 1283330003872 Q-loop/lid; other site 1283330003873 ABC transporter signature motif; other site 1283330003874 Walker B; other site 1283330003875 D-loop; other site 1283330003876 H-loop/switch region; other site 1283330003877 TOBE domain; Region: TOBE_2; pfam08402 1283330003878 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1283330003879 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1283330003880 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1283330003881 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1283330003882 putative GSH binding site [chemical binding]; other site 1283330003883 catalytic residues [active] 1283330003884 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1283330003885 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1283330003886 heme binding site [chemical binding]; other site 1283330003887 ferroxidase pore; other site 1283330003888 ferroxidase diiron center [ion binding]; other site 1283330003889 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1283330003890 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1283330003891 dimer interface [polypeptide binding]; other site 1283330003892 catalytic site [active] 1283330003893 putative active site [active] 1283330003894 putative substrate binding site [chemical binding]; other site 1283330003895 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1283330003896 active site 1283330003897 substrate binding pocket [chemical binding]; other site 1283330003898 dimer interface [polypeptide binding]; other site 1283330003899 argininosuccinate synthase; Provisional; Region: PRK13820 1283330003900 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1283330003901 ANP binding site [chemical binding]; other site 1283330003902 Substrate Binding Site II [chemical binding]; other site 1283330003903 Substrate Binding Site I [chemical binding]; other site 1283330003904 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1283330003905 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1283330003906 GTP binding site; other site 1283330003907 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1283330003908 MPT binding site; other site 1283330003909 trimer interface [polypeptide binding]; other site 1283330003910 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1283330003911 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1283330003912 dimer interface [polypeptide binding]; other site 1283330003913 putative functional site; other site 1283330003914 putative MPT binding site; other site 1283330003915 lipid kinase; Reviewed; Region: PRK13054 1283330003916 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1283330003917 lytic murein transglycosylase; Provisional; Region: PRK11619 1283330003918 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1283330003919 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1283330003920 catalytic residue [active] 1283330003921 ABC transporter ATPase component; Reviewed; Region: PRK11147 1283330003922 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283330003923 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283330003924 ABC transporter; Region: ABC_tran_2; pfam12848 1283330003925 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283330003926 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283330003927 Ligand Binding Site [chemical binding]; other site 1283330003928 benzoate transport; Region: 2A0115; TIGR00895 1283330003929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330003930 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330003931 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1283330003932 active site 1283330003933 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 1283330003934 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283330003935 substrate binding site [chemical binding]; other site 1283330003936 oxyanion hole (OAH) forming residues; other site 1283330003937 trimer interface [polypeptide binding]; other site 1283330003938 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 1283330003939 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1283330003940 NAD(P) binding site [chemical binding]; other site 1283330003941 catalytic residues [active] 1283330003942 feruloyl-CoA synthase; Reviewed; Region: PRK08180 1283330003943 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 1283330003944 acyl-activating enzyme (AAE) consensus motif; other site 1283330003945 putative AMP binding site [chemical binding]; other site 1283330003946 putative active site [active] 1283330003947 putative CoA binding site [chemical binding]; other site 1283330003948 putative acyltransferase; Provisional; Region: PRK05790 1283330003949 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283330003950 dimer interface [polypeptide binding]; other site 1283330003951 active site 1283330003952 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1283330003953 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1283330003954 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283330003955 active site 1283330003956 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1283330003957 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1283330003958 Ligand binding site [chemical binding]; other site 1283330003959 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1283330003960 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1283330003961 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1283330003962 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283330003963 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283330003964 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283330003965 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1283330003966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330003967 active site 1283330003968 phosphorylation site [posttranslational modification] 1283330003969 intermolecular recognition site; other site 1283330003970 dimerization interface [polypeptide binding]; other site 1283330003971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283330003972 DNA binding site [nucleotide binding] 1283330003973 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1283330003974 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283330003975 dimerization interface [polypeptide binding]; other site 1283330003976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330003977 dimer interface [polypeptide binding]; other site 1283330003978 phosphorylation site [posttranslational modification] 1283330003979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330003980 ATP binding site [chemical binding]; other site 1283330003981 Mg2+ binding site [ion binding]; other site 1283330003982 G-X-G motif; other site 1283330003983 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1283330003984 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283330003985 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283330003986 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1283330003987 Protein export membrane protein; Region: SecD_SecF; cl14618 1283330003988 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1283330003989 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1283330003990 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 1283330003991 Protein of unknown function (DUF2501); Region: DUF2501; cl08197 1283330003992 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1283330003993 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1283330003994 NAD(P) binding site [chemical binding]; other site 1283330003995 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1283330003996 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1283330003997 Cupin domain; Region: Cupin_2; cl17218 1283330003998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330003999 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1283330004000 MarR family; Region: MarR_2; pfam12802 1283330004001 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1283330004002 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283330004003 substrate binding site [chemical binding]; other site 1283330004004 oxyanion hole (OAH) forming residues; other site 1283330004005 trimer interface [polypeptide binding]; other site 1283330004006 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283330004007 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283330004008 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283330004009 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1283330004010 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283330004011 dimer interface [polypeptide binding]; other site 1283330004012 active site 1283330004013 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 1283330004014 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1283330004015 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1283330004016 active site 1283330004017 interdomain interaction site; other site 1283330004018 putative metal-binding site [ion binding]; other site 1283330004019 nucleotide binding site [chemical binding]; other site 1283330004020 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1283330004021 domain I; other site 1283330004022 DNA binding groove [nucleotide binding] 1283330004023 phosphate binding site [ion binding]; other site 1283330004024 domain II; other site 1283330004025 domain III; other site 1283330004026 nucleotide binding site [chemical binding]; other site 1283330004027 catalytic site [active] 1283330004028 domain IV; other site 1283330004029 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1283330004030 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1283330004031 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1283330004032 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1283330004033 putative fimbrial outer membrane usher protein SteB; Provisional; Region: PRK15273 1283330004034 Cell division inhibitor SulA; Region: SulA; cl01880 1283330004035 LexA repressor; Validated; Region: PRK00215 1283330004036 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1283330004037 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1283330004038 Catalytic site [active] 1283330004039 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283330004040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283330004041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1283330004042 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1283330004043 beta-hexosaminidase; Provisional; Region: PRK05337 1283330004044 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1283330004045 5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136 1283330004046 Protein of unknown function (DUF2803); Region: DUF2803; pfam10972 1283330004047 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1283330004048 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1283330004049 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283330004050 ATP binding site [chemical binding]; other site 1283330004051 putative Mg++ binding site [ion binding]; other site 1283330004052 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283330004053 nucleotide binding region [chemical binding]; other site 1283330004054 ATP-binding site [chemical binding]; other site 1283330004055 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1283330004056 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 1283330004057 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1283330004058 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1283330004059 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 1283330004060 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1283330004061 E3 interaction surface; other site 1283330004062 lipoyl attachment site [posttranslational modification]; other site 1283330004063 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 1283330004064 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 1283330004065 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 1283330004066 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 1283330004067 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 1283330004068 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 1283330004069 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 1283330004070 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283330004071 catalytic loop [active] 1283330004072 iron binding site [ion binding]; other site 1283330004073 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 1283330004074 FAD binding pocket [chemical binding]; other site 1283330004075 FAD binding motif [chemical binding]; other site 1283330004076 phosphate binding motif [ion binding]; other site 1283330004077 beta-alpha-beta structure motif; other site 1283330004078 NAD binding pocket [chemical binding]; other site 1283330004079 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1283330004080 ApbE family; Region: ApbE; pfam02424 1283330004081 Protein of unknown function (DUF539); Region: DUF539; cl01129 1283330004082 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1283330004083 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1283330004084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283330004085 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1283330004086 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1283330004087 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 1283330004088 active site 1283330004089 catalytic site [active] 1283330004090 metal binding site [ion binding]; metal-binding site 1283330004091 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1283330004092 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1283330004093 FtsX-like permease family; Region: FtsX; pfam02687 1283330004094 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1283330004095 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1283330004096 Walker A/P-loop; other site 1283330004097 ATP binding site [chemical binding]; other site 1283330004098 Q-loop/lid; other site 1283330004099 ABC transporter signature motif; other site 1283330004100 Walker B; other site 1283330004101 D-loop; other site 1283330004102 H-loop/switch region; other site 1283330004103 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1283330004104 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1283330004105 FtsX-like permease family; Region: FtsX; pfam02687 1283330004106 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1283330004107 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1283330004108 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1283330004109 Competence protein; Region: Competence; pfam03772 1283330004110 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1283330004111 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1283330004112 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1283330004113 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1283330004114 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1283330004115 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1283330004116 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1283330004117 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1283330004118 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1283330004119 Ligand binding site; other site 1283330004120 oligomer interface; other site 1283330004121 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1283330004122 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1283330004123 active site 1283330004124 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1283330004125 FAD binding domain; Region: FAD_binding_4; pfam01565 1283330004126 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1283330004127 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1283330004128 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1283330004129 homodimer interface [polypeptide binding]; other site 1283330004130 oligonucleotide binding site [chemical binding]; other site 1283330004131 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1283330004132 active site 1283330004133 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1283330004134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330004135 motif II; other site 1283330004136 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1283330004137 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1283330004138 tandem repeat interface [polypeptide binding]; other site 1283330004139 oligomer interface [polypeptide binding]; other site 1283330004140 active site residues [active] 1283330004141 Maf-like protein; Region: Maf; pfam02545 1283330004142 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1283330004143 active site 1283330004144 dimer interface [polypeptide binding]; other site 1283330004145 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1283330004146 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1283330004147 putative phosphate acyltransferase; Provisional; Region: PRK05331 1283330004148 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1283330004149 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1283330004150 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1283330004151 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1283330004152 NAD(P) binding site [chemical binding]; other site 1283330004153 homotetramer interface [polypeptide binding]; other site 1283330004154 homodimer interface [polypeptide binding]; other site 1283330004155 active site 1283330004156 acyl carrier protein; Provisional; Region: acpP; PRK00982 1283330004157 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1283330004158 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1283330004159 dimer interface [polypeptide binding]; other site 1283330004160 active site 1283330004161 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1283330004162 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1283330004163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330004164 catalytic residue [active] 1283330004165 YceG-like family; Region: YceG; pfam02618 1283330004166 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1283330004167 dimerization interface [polypeptide binding]; other site 1283330004168 thymidylate kinase; Validated; Region: tmk; PRK00698 1283330004169 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1283330004170 TMP-binding site; other site 1283330004171 ATP-binding site [chemical binding]; other site 1283330004172 DNA polymerase III subunit delta'; Validated; Region: PRK05707 1283330004173 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1283330004174 PilZ domain; Region: PilZ; cl01260 1283330004175 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1283330004176 active site 1283330004177 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283330004178 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283330004179 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1283330004180 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1283330004181 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283330004182 catalytic residue [active] 1283330004183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 1283330004184 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1283330004185 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 1283330004186 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1283330004187 putative active site [active] 1283330004188 Fe(II) binding site [ion binding]; other site 1283330004189 putative dimer interface [polypeptide binding]; other site 1283330004190 putative tetramer interface [polypeptide binding]; other site 1283330004191 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283330004192 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1283330004193 active site 1283330004194 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1283330004195 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1283330004196 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1283330004197 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1283330004198 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 1283330004199 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1283330004200 Bacterial transcriptional regulator; Region: IclR; pfam01614 1283330004201 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 1283330004202 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1283330004203 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1283330004204 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1283330004205 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1283330004206 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1283330004207 active site 1283330004208 catalytic residues [active] 1283330004209 metal binding site [ion binding]; metal-binding site 1283330004210 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1283330004211 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1283330004212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330004213 putative substrate translocation pore; other site 1283330004214 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330004215 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1283330004216 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1283330004217 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1283330004218 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1283330004219 Ligand binding site [chemical binding]; other site 1283330004220 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1283330004221 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1283330004222 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1283330004223 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1283330004224 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1283330004225 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1283330004226 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283330004227 ligand binding site [chemical binding]; other site 1283330004228 Protein of unknown function (DUF2897); Region: DUF2897; pfam11446 1283330004229 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1283330004230 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1283330004231 active site 1283330004232 dimer interface [polypeptide binding]; other site 1283330004233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 1283330004234 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 1283330004235 elongation factor P; Validated; Region: PRK00529 1283330004236 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1283330004237 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1283330004238 RNA binding site [nucleotide binding]; other site 1283330004239 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1283330004240 RNA binding site [nucleotide binding]; other site 1283330004241 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1283330004242 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1283330004243 MarR family; Region: MarR; pfam01047 1283330004244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330004245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330004246 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283330004247 putative effector binding pocket; other site 1283330004248 dimerization interface [polypeptide binding]; other site 1283330004249 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1283330004250 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1283330004251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330004252 S-adenosylmethionine binding site [chemical binding]; other site 1283330004253 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1283330004254 helicase 45; Provisional; Region: PTZ00424 1283330004255 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1283330004256 ATP binding site [chemical binding]; other site 1283330004257 Mg++ binding site [ion binding]; other site 1283330004258 motif III; other site 1283330004259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283330004260 nucleotide binding region [chemical binding]; other site 1283330004261 ATP-binding site [chemical binding]; other site 1283330004262 DbpA RNA binding domain; Region: DbpA; pfam03880 1283330004263 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 1283330004264 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 1283330004265 heat shock protein HtpX; Provisional; Region: PRK05457 1283330004266 aminotransferase AlaT; Validated; Region: PRK09265 1283330004267 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283330004268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330004269 homodimer interface [polypeptide binding]; other site 1283330004270 catalytic residue [active] 1283330004271 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1283330004272 SelR domain; Region: SelR; pfam01641 1283330004273 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1283330004274 catalytic residues [active] 1283330004275 dimer interface [polypeptide binding]; other site 1283330004276 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1283330004277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330004278 ATP binding site [chemical binding]; other site 1283330004279 Mg2+ binding site [ion binding]; other site 1283330004280 G-X-G motif; other site 1283330004281 Response regulator receiver domain; Region: Response_reg; pfam00072 1283330004282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330004283 active site 1283330004284 phosphorylation site [posttranslational modification] 1283330004285 intermolecular recognition site; other site 1283330004286 dimerization interface [polypeptide binding]; other site 1283330004287 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1283330004288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330004289 Walker A motif; other site 1283330004290 ATP binding site [chemical binding]; other site 1283330004291 Walker B motif; other site 1283330004292 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1283330004293 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1283330004294 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1283330004295 active site 1283330004296 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1283330004297 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1283330004298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330004299 Walker A/P-loop; other site 1283330004300 ATP binding site [chemical binding]; other site 1283330004301 Q-loop/lid; other site 1283330004302 ABC transporter signature motif; other site 1283330004303 Walker B; other site 1283330004304 D-loop; other site 1283330004305 H-loop/switch region; other site 1283330004306 inner membrane transport permease; Provisional; Region: PRK15066 1283330004307 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1283330004308 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1283330004309 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283330004310 dimerization interface [polypeptide binding]; other site 1283330004311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330004312 dimer interface [polypeptide binding]; other site 1283330004313 phosphorylation site [posttranslational modification] 1283330004314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330004315 ATP binding site [chemical binding]; other site 1283330004316 Mg2+ binding site [ion binding]; other site 1283330004317 G-X-G motif; other site 1283330004318 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1283330004319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330004320 active site 1283330004321 phosphorylation site [posttranslational modification] 1283330004322 intermolecular recognition site; other site 1283330004323 dimerization interface [polypeptide binding]; other site 1283330004324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283330004325 DNA binding site [nucleotide binding] 1283330004326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1283330004327 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1283330004328 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1283330004329 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1283330004330 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1283330004331 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1283330004332 putative FMN binding site [chemical binding]; other site 1283330004333 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1283330004334 dimerization interface [polypeptide binding]; other site 1283330004335 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283330004336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330004337 ATP binding site [chemical binding]; other site 1283330004338 G-X-G motif; other site 1283330004339 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1283330004340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330004341 active site 1283330004342 phosphorylation site [posttranslational modification] 1283330004343 intermolecular recognition site; other site 1283330004344 dimerization interface [polypeptide binding]; other site 1283330004345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283330004346 DNA binding site [nucleotide binding] 1283330004347 YciI-like protein; Reviewed; Region: PRK11370 1283330004348 intracellular septation protein A; Reviewed; Region: PRK00259 1283330004349 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1283330004350 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1283330004351 active site 1283330004352 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1283330004353 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1283330004354 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1283330004355 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1283330004356 phosphogluconate dehydratase; Validated; Region: PRK09054 1283330004357 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1283330004358 glucokinase; Provisional; Region: glk; PRK00292 1283330004359 glucokinase, proteobacterial type; Region: glk; TIGR00749 1283330004360 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1283330004361 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1283330004362 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1283330004363 putative active site [active] 1283330004364 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1283330004365 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1283330004366 putative active site [active] 1283330004367 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1283330004368 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1283330004369 active site 1283330004370 intersubunit interface [polypeptide binding]; other site 1283330004371 catalytic residue [active] 1283330004372 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1283330004373 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1283330004374 RNA binding surface [nucleotide binding]; other site 1283330004375 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1283330004376 probable active site [active] 1283330004377 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1283330004378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330004379 NAD(P) binding site [chemical binding]; other site 1283330004380 active site 1283330004381 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1283330004382 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1283330004383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330004384 motif II; other site 1283330004385 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1283330004386 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1283330004387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330004388 S-adenosylmethionine binding site [chemical binding]; other site 1283330004389 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1283330004390 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1283330004391 active site 1283330004392 putative substrate binding pocket [chemical binding]; other site 1283330004393 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1283330004394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1283330004395 Probable transposase; Region: OrfB_IS605; pfam01385 1283330004396 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1283330004397 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283330004398 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330004399 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330004400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1283330004401 Integrase core domain; Region: rve; pfam00665 1283330004402 Integrase core domain; Region: rve_3; pfam13683 1283330004403 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1283330004404 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1283330004405 DNA gyrase subunit A; Validated; Region: PRK05560 1283330004406 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1283330004407 CAP-like domain; other site 1283330004408 active site 1283330004409 primary dimer interface [polypeptide binding]; other site 1283330004410 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1283330004411 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1283330004412 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1283330004413 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1283330004414 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1283330004415 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1283330004416 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1283330004417 homodimer interface [polypeptide binding]; other site 1283330004418 substrate-cofactor binding pocket; other site 1283330004419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330004420 catalytic residue [active] 1283330004421 Chorismate mutase type II; Region: CM_2; cl00693 1283330004422 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1283330004423 Prephenate dehydratase; Region: PDT; pfam00800 1283330004424 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1283330004425 putative L-Phe binding site [chemical binding]; other site 1283330004426 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1283330004427 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283330004428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330004429 homodimer interface [polypeptide binding]; other site 1283330004430 catalytic residue [active] 1283330004431 bifunctional cyclohexadienyl dehydrogenase/ 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK14806 1283330004432 prephenate dehydrogenase; Validated; Region: PRK08507 1283330004433 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1283330004434 hinge; other site 1283330004435 active site 1283330004436 cytidylate kinase; Provisional; Region: cmk; PRK00023 1283330004437 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1283330004438 CMP-binding site; other site 1283330004439 The sites determining sugar specificity; other site 1283330004440 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1283330004441 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1283330004442 RNA binding site [nucleotide binding]; other site 1283330004443 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1283330004444 RNA binding site [nucleotide binding]; other site 1283330004445 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1283330004446 RNA binding site [nucleotide binding]; other site 1283330004447 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1283330004448 RNA binding site [nucleotide binding]; other site 1283330004449 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1283330004450 RNA binding site [nucleotide binding]; other site 1283330004451 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1283330004452 RNA binding site [nucleotide binding]; other site 1283330004453 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1283330004454 IHF dimer interface [polypeptide binding]; other site 1283330004455 IHF - DNA interface [nucleotide binding]; other site 1283330004456 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1283330004457 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1283330004458 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1283330004459 Beta-Casp domain; Region: Beta-Casp; smart01027 1283330004460 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1283330004461 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1283330004462 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 1283330004463 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1283330004464 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1283330004465 NAD binding site [chemical binding]; other site 1283330004466 substrate binding site [chemical binding]; other site 1283330004467 homodimer interface [polypeptide binding]; other site 1283330004468 active site 1283330004469 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1283330004470 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1283330004471 NADP binding site [chemical binding]; other site 1283330004472 active site 1283330004473 putative substrate binding site [chemical binding]; other site 1283330004474 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1283330004475 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1283330004476 substrate binding site; other site 1283330004477 tetramer interface; other site 1283330004478 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 1283330004479 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1283330004480 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1283330004481 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1283330004482 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1283330004483 Walker A/P-loop; other site 1283330004484 ATP binding site [chemical binding]; other site 1283330004485 Q-loop/lid; other site 1283330004486 ABC transporter signature motif; other site 1283330004487 Walker B; other site 1283330004488 D-loop; other site 1283330004489 H-loop/switch region; other site 1283330004490 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1283330004491 putative carbohydrate binding site [chemical binding]; other site 1283330004492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1283330004493 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1283330004494 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 1283330004495 Probable Catalytic site; other site 1283330004496 metal-binding site 1283330004497 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1283330004498 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1283330004499 Probable Catalytic site; other site 1283330004500 metal-binding site 1283330004501 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610 1283330004502 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1283330004503 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1283330004504 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1283330004505 Ligand binding site; other site 1283330004506 Putative Catalytic site; other site 1283330004507 DXD motif; other site 1283330004508 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1283330004509 Transposase IS200 like; Region: Y1_Tnp; cl00848 1283330004510 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1283330004511 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1283330004512 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1283330004513 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1283330004514 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 1283330004515 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1283330004516 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1283330004517 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1283330004518 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1283330004519 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1283330004520 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1283330004521 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1283330004522 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1283330004523 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1283330004524 Walker A motif; other site 1283330004525 ATP binding site [chemical binding]; other site 1283330004526 Walker B motif; other site 1283330004527 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1283330004528 ligand-binding site [chemical binding]; other site 1283330004529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1283330004530 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1283330004531 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1283330004532 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 1283330004533 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283330004534 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1283330004535 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1283330004536 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1283330004537 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283330004538 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1283330004539 Walker A/P-loop; other site 1283330004540 ATP binding site [chemical binding]; other site 1283330004541 Q-loop/lid; other site 1283330004542 ABC transporter signature motif; other site 1283330004543 Walker B; other site 1283330004544 D-loop; other site 1283330004545 H-loop/switch region; other site 1283330004546 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1283330004547 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283330004548 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283330004549 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1283330004550 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1283330004551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283330004552 ATP binding site [chemical binding]; other site 1283330004553 putative Mg++ binding site [ion binding]; other site 1283330004554 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283330004555 nucleotide binding region [chemical binding]; other site 1283330004556 ATP-binding site [chemical binding]; other site 1283330004557 Helicase associated domain (HA2); Region: HA2; pfam04408 1283330004558 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1283330004559 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1283330004560 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1283330004561 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1283330004562 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1283330004563 MarR family; Region: MarR_2; cl17246 1283330004564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283330004565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330004566 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1283330004567 Protein of unknown function (DUF541); Region: SIMPL; cl01077 1283330004568 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283330004569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330004570 putative substrate translocation pore; other site 1283330004571 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1283330004572 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1283330004573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330004574 beta-ketothiolase; Provisional; Region: PRK09051 1283330004575 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283330004576 dimer interface [polypeptide binding]; other site 1283330004577 active site 1283330004578 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1283330004579 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283330004580 substrate binding site [chemical binding]; other site 1283330004581 oxyanion hole (OAH) forming residues; other site 1283330004582 trimer interface [polypeptide binding]; other site 1283330004583 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283330004584 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283330004585 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283330004586 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1283330004587 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283330004588 active site 1283330004589 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1283330004590 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1283330004591 Ligand binding site [chemical binding]; other site 1283330004592 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1283330004593 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1283330004594 electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022 1283330004595 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1283330004596 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1283330004597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283330004598 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1283330004599 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1283330004600 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1283330004601 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1283330004602 Integrase core domain; Region: rve_3; pfam13683 1283330004603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330004604 NAD(P) binding site [chemical binding]; other site 1283330004605 active site 1283330004606 LysR family transcriptional regulator; Provisional; Region: PRK14997 1283330004607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330004608 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283330004609 putative effector binding pocket; other site 1283330004610 dimerization interface [polypeptide binding]; other site 1283330004611 short chain dehydrogenase; Provisional; Region: PRK06523 1283330004612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330004613 NAD(P) binding site [chemical binding]; other site 1283330004614 active site 1283330004615 L-fucose transporter; Provisional; Region: PRK10133; cl17665 1283330004616 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330004617 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330004618 Transposase; Region: HTH_Tnp_1; cl17663 1283330004619 putative transposase OrfB; Reviewed; Region: PHA02517 1283330004620 HTH-like domain; Region: HTH_21; pfam13276 1283330004621 Integrase core domain; Region: rve; pfam00665 1283330004622 Integrase core domain; Region: rve_3; pfam13683 1283330004623 Transposase domain (DUF772); Region: DUF772; pfam05598 1283330004624 Integrase core domain; Region: rve_3; cl15866 1283330004625 polyol permease family; Region: 2A0118; TIGR00897 1283330004626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330004627 putative substrate translocation pore; other site 1283330004628 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1283330004629 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1283330004630 inhibitor binding site; inhibition site 1283330004631 catalytic Zn binding site [ion binding]; other site 1283330004632 structural Zn binding site [ion binding]; other site 1283330004633 NADP binding site [chemical binding]; other site 1283330004634 tetramer interface [polypeptide binding]; other site 1283330004635 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1283330004636 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1283330004637 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330004638 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1283330004639 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1283330004640 putative substrate binding site [chemical binding]; other site 1283330004641 putative ATP binding site [chemical binding]; other site 1283330004642 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1283330004643 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1283330004644 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1283330004645 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1283330004646 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1283330004647 active site 1283330004648 dimer interface [polypeptide binding]; other site 1283330004649 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1283330004650 dimer interface [polypeptide binding]; other site 1283330004651 active site 1283330004652 Transposase domain (DUF772); Region: DUF772; pfam05598 1283330004653 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283330004654 DDE superfamily endonuclease; Region: DDE_4; cl17710 1283330004655 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1283330004656 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283330004657 trimer interface; other site 1283330004658 sugar binding site [chemical binding]; other site 1283330004659 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 1283330004660 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283330004661 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1283330004662 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1283330004663 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283330004664 catalytic residue [active] 1283330004665 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1283330004666 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1283330004667 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1283330004668 transcriptional regulator; Provisional; Region: PRK10632 1283330004669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330004670 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_10; cd08480 1283330004671 putative effector binding pocket; other site 1283330004672 putative dimerization interface [polypeptide binding]; other site 1283330004673 short chain dehydrogenase; Provisional; Region: PRK08339 1283330004674 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1283330004675 putative NAD(P) binding site [chemical binding]; other site 1283330004676 putative active site [active] 1283330004677 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1283330004678 putative hydrophobic ligand binding site [chemical binding]; other site 1283330004679 protein interface [polypeptide binding]; other site 1283330004680 gate; other site 1283330004681 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1283330004682 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1283330004683 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1283330004684 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1283330004685 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1283330004686 Walker A/P-loop; other site 1283330004687 ATP binding site [chemical binding]; other site 1283330004688 Q-loop/lid; other site 1283330004689 ABC transporter signature motif; other site 1283330004690 Walker B; other site 1283330004691 D-loop; other site 1283330004692 H-loop/switch region; other site 1283330004693 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1283330004694 Walker A/P-loop; other site 1283330004695 ATP binding site [chemical binding]; other site 1283330004696 Q-loop/lid; other site 1283330004697 ABC transporter signature motif; other site 1283330004698 Walker B; other site 1283330004699 D-loop; other site 1283330004700 H-loop/switch region; other site 1283330004701 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1283330004702 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1283330004703 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283330004704 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283330004705 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1283330004706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1283330004707 Probable transposase; Region: OrfB_IS605; pfam01385 1283330004708 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1283330004709 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 1283330004710 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 1283330004711 putative active site [active] 1283330004712 putative FMN binding site [chemical binding]; other site 1283330004713 putative substrate binding site [chemical binding]; other site 1283330004714 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1283330004715 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1283330004716 putative NAD(P) binding site [chemical binding]; other site 1283330004717 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1283330004718 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330004719 substrate binding pocket [chemical binding]; other site 1283330004720 membrane-bound complex binding site; other site 1283330004721 hinge residues; other site 1283330004722 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1283330004723 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1283330004724 active site 1283330004725 nucleophile elbow; other site 1283330004726 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1283330004727 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1283330004728 Protein of unknown function DUF82; Region: DUF82; pfam01927 1283330004729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330004730 NAD(P) binding site [chemical binding]; other site 1283330004731 active site 1283330004732 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1283330004733 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1283330004734 RNA binding surface [nucleotide binding]; other site 1283330004735 Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555 1283330004736 active site 1283330004737 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1283330004738 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1283330004739 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1283330004740 S1 domain; Region: S1_2; pfam13509 1283330004741 S1 domain; Region: S1_2; pfam13509 1283330004742 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283330004743 DNA-binding site [nucleotide binding]; DNA binding site 1283330004744 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 1283330004745 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1283330004746 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1283330004747 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1283330004748 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1283330004749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1283330004750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330004751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330004752 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1283330004753 putative dimerization interface [polypeptide binding]; other site 1283330004754 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1283330004755 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1283330004756 Citrate transporter; Region: CitMHS; pfam03600 1283330004757 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330004758 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330004759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330004760 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1283330004761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1283330004762 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 1283330004763 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 1283330004764 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 1283330004765 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1283330004766 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 1283330004767 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1283330004768 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cl08187 1283330004769 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1283330004770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330004771 non-specific DNA binding site [nucleotide binding]; other site 1283330004772 salt bridge; other site 1283330004773 sequence-specific DNA binding site [nucleotide binding]; other site 1283330004774 TPR repeat; Region: TPR_11; pfam13414 1283330004775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1283330004776 TPR motif; other site 1283330004777 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1283330004778 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1283330004779 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1283330004780 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283330004781 putative ADP-binding pocket [chemical binding]; other site 1283330004782 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1283330004783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330004784 putative substrate translocation pore; other site 1283330004785 MarR family; Region: MarR_2; pfam12802 1283330004786 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330004787 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1283330004788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330004789 active site 1283330004790 phosphorylation site [posttranslational modification] 1283330004791 intermolecular recognition site; other site 1283330004792 dimerization interface [polypeptide binding]; other site 1283330004793 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1283330004794 DNA binding residues [nucleotide binding] 1283330004795 dimerization interface [polypeptide binding]; other site 1283330004796 PAS domain S-box; Region: sensory_box; TIGR00229 1283330004797 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330004798 putative active site [active] 1283330004799 heme pocket [chemical binding]; other site 1283330004800 Histidine kinase; Region: HisKA_3; pfam07730 1283330004801 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1283330004802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330004803 ATP binding site [chemical binding]; other site 1283330004804 Mg2+ binding site [ion binding]; other site 1283330004805 G-X-G motif; other site 1283330004806 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283330004807 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1283330004808 substrate binding site [chemical binding]; other site 1283330004809 oxyanion hole (OAH) forming residues; other site 1283330004810 trimer interface [polypeptide binding]; other site 1283330004811 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283330004812 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283330004813 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283330004814 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1283330004815 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283330004816 dimer interface [polypeptide binding]; other site 1283330004817 active site 1283330004818 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 1283330004819 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1283330004820 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1283330004821 acyl-activating enzyme (AAE) consensus motif; other site 1283330004822 AMP binding site [chemical binding]; other site 1283330004823 active site 1283330004824 CoA binding site [chemical binding]; other site 1283330004825 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1283330004826 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1283330004827 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283330004828 active site 1283330004829 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1283330004830 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1283330004831 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1283330004832 CoenzymeA binding site [chemical binding]; other site 1283330004833 subunit interaction site [polypeptide binding]; other site 1283330004834 PHB binding site; other site 1283330004835 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1283330004836 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283330004837 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1283330004838 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283330004839 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1283330004840 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1283330004841 Nucleoside recognition; Region: Gate; pfam07670 1283330004842 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1283330004843 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1283330004844 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 1283330004845 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1283330004846 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1283330004847 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1283330004848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330004849 dimer interface [polypeptide binding]; other site 1283330004850 conserved gate region; other site 1283330004851 ABC-ATPase subunit interface; other site 1283330004852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330004853 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1283330004854 Walker A/P-loop; other site 1283330004855 ATP binding site [chemical binding]; other site 1283330004856 Q-loop/lid; other site 1283330004857 ABC transporter signature motif; other site 1283330004858 Walker B; other site 1283330004859 D-loop; other site 1283330004860 H-loop/switch region; other site 1283330004861 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330004862 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1283330004863 substrate binding pocket [chemical binding]; other site 1283330004864 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1283330004865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283330004866 DNA-binding site [nucleotide binding]; DNA binding site 1283330004867 FCD domain; Region: FCD; pfam07729 1283330004868 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1283330004869 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1283330004870 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1283330004871 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1283330004872 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1283330004873 NAD binding site [chemical binding]; other site 1283330004874 homotetramer interface [polypeptide binding]; other site 1283330004875 homodimer interface [polypeptide binding]; other site 1283330004876 substrate binding site [chemical binding]; other site 1283330004877 active site 1283330004878 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1283330004879 PAS fold; Region: PAS; pfam00989 1283330004880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330004881 putative active site [active] 1283330004882 heme pocket [chemical binding]; other site 1283330004883 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1283330004884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330004885 Walker B motif; other site 1283330004886 arginine finger; other site 1283330004887 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283330004888 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1283330004889 substrate binding site [chemical binding]; other site 1283330004890 oxyanion hole (OAH) forming residues; other site 1283330004891 trimer interface [polypeptide binding]; other site 1283330004892 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1283330004893 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1283330004894 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1283330004895 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1283330004896 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1283330004897 putative active site [active] 1283330004898 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1283330004899 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1283330004900 active site 1283330004901 dimer interface [polypeptide binding]; other site 1283330004902 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1283330004903 dimer interface [polypeptide binding]; other site 1283330004904 active site 1283330004905 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1283330004906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330004907 putative substrate translocation pore; other site 1283330004908 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1283330004909 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1283330004910 putative substrate binding site [chemical binding]; other site 1283330004911 putative ATP binding site [chemical binding]; other site 1283330004912 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 1283330004913 active site 1283330004914 catalytic residues [active] 1283330004915 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283330004916 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283330004917 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330004918 N-terminal plug; other site 1283330004919 ligand-binding site [chemical binding]; other site 1283330004920 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283330004921 FecR protein; Region: FecR; pfam04773 1283330004922 RNA polymerase sigma factor; Provisional; Region: PRK12528 1283330004923 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330004924 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1283330004925 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1283330004926 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283330004927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330004928 putative substrate translocation pore; other site 1283330004929 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330004930 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330004931 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 1283330004932 putative dimerization interface [polypeptide binding]; other site 1283330004933 putative effector binding pocket; other site 1283330004934 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1283330004935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330004936 S-adenosylmethionine binding site [chemical binding]; other site 1283330004937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283330004938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330004939 dimer interface [polypeptide binding]; other site 1283330004940 phosphorylation site [posttranslational modification] 1283330004941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330004942 ATP binding site [chemical binding]; other site 1283330004943 Mg2+ binding site [ion binding]; other site 1283330004944 G-X-G motif; other site 1283330004945 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1283330004946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330004947 active site 1283330004948 phosphorylation site [posttranslational modification] 1283330004949 intermolecular recognition site; other site 1283330004950 dimerization interface [polypeptide binding]; other site 1283330004951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283330004952 DNA binding site [nucleotide binding] 1283330004953 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1283330004954 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1283330004955 catalytic core [active] 1283330004956 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1283330004957 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1283330004958 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1283330004959 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1283330004960 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1283330004961 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1283330004962 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1283330004963 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1283330004964 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1283330004965 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1283330004966 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283330004967 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1283330004968 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1283330004969 Predicted deacetylase [General function prediction only]; Region: COG3233 1283330004970 putative active site [active] 1283330004971 putative Zn binding site [ion binding]; other site 1283330004972 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1283330004973 DNA-binding site [nucleotide binding]; DNA binding site 1283330004974 RNA-binding motif; other site 1283330004975 Protein of unknown function (DUF2789); Region: DUF2789; pfam10982 1283330004976 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283330004977 Ligand Binding Site [chemical binding]; other site 1283330004978 O-Antigen ligase; Region: Wzy_C; cl04850 1283330004979 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1283330004980 active site 1283330004981 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1283330004982 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283330004983 ATP binding site [chemical binding]; other site 1283330004984 putative Mg++ binding site [ion binding]; other site 1283330004985 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283330004986 nucleotide binding region [chemical binding]; other site 1283330004987 ATP-binding site [chemical binding]; other site 1283330004988 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1283330004989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330004990 dimer interface [polypeptide binding]; other site 1283330004991 phosphorylation site [posttranslational modification] 1283330004992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330004993 ATP binding site [chemical binding]; other site 1283330004994 Mg2+ binding site [ion binding]; other site 1283330004995 G-X-G motif; other site 1283330004996 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1283330004997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330004998 active site 1283330004999 phosphorylation site [posttranslational modification] 1283330005000 intermolecular recognition site; other site 1283330005001 dimerization interface [polypeptide binding]; other site 1283330005002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330005003 Walker A motif; other site 1283330005004 ATP binding site [chemical binding]; other site 1283330005005 Walker B motif; other site 1283330005006 arginine finger; other site 1283330005007 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1283330005008 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330005009 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1283330005010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330005011 putative substrate translocation pore; other site 1283330005012 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1283330005013 apolar tunnel; other site 1283330005014 heme binding site [chemical binding]; other site 1283330005015 dimerization interface [polypeptide binding]; other site 1283330005016 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1283330005017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330005018 Walker A motif; other site 1283330005019 ATP binding site [chemical binding]; other site 1283330005020 Walker B motif; other site 1283330005021 arginine finger; other site 1283330005022 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1283330005023 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1283330005024 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1283330005025 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1283330005026 PhnA protein; Region: PhnA; pfam03831 1283330005027 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330005028 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1283330005029 putative active site [active] 1283330005030 putative catalytic site [active] 1283330005031 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 1283330005032 hypothetical protein; Provisional; Region: PRK12378 1283330005033 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 1283330005034 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1283330005035 hypothetical protein; Provisional; Region: PRK10621 1283330005036 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1283330005037 Cell division protein ZapA; Region: ZapA; pfam05164 1283330005038 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1283330005039 Peptidase family U32; Region: Peptidase_U32; pfam01136 1283330005040 Collagenase; Region: DUF3656; pfam12392 1283330005041 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 1283330005042 30S subunit binding site; other site 1283330005043 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1283330005044 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1283330005045 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1283330005046 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283330005047 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283330005048 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283330005049 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283330005050 dimerization interface [polypeptide binding]; other site 1283330005051 putative DNA binding site [nucleotide binding]; other site 1283330005052 putative Zn2+ binding site [ion binding]; other site 1283330005053 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 1283330005054 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1283330005055 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1283330005056 FMN binding site [chemical binding]; other site 1283330005057 active site 1283330005058 substrate binding site [chemical binding]; other site 1283330005059 catalytic residue [active] 1283330005060 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1283330005061 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1283330005062 NAD(P) binding site [chemical binding]; other site 1283330005063 catalytic residues [active] 1283330005064 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283330005065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283330005066 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1283330005067 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1283330005068 NADP binding site [chemical binding]; other site 1283330005069 dimer interface [polypeptide binding]; other site 1283330005070 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 1283330005071 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1283330005072 IHF dimer interface [polypeptide binding]; other site 1283330005073 IHF - DNA interface [nucleotide binding]; other site 1283330005074 Sodium Bile acid symporter family; Region: SBF; cl17470 1283330005075 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1283330005076 DNA binding residues [nucleotide binding] 1283330005077 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1283330005078 Heavy-metal-associated domain; Region: HMA; pfam00403 1283330005079 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1283330005080 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1283330005081 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1283330005082 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1283330005083 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1283330005084 Thermostable hemolysin; Region: T_hemolysin; pfam12261 1283330005085 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1283330005086 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914 1283330005087 acyl-activating enzyme (AAE) consensus motif; other site 1283330005088 putative AMP binding site [chemical binding]; other site 1283330005089 putative active site [active] 1283330005090 putative CoA binding site [chemical binding]; other site 1283330005091 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1283330005092 heme binding pocket [chemical binding]; other site 1283330005093 heme ligand [chemical binding]; other site 1283330005094 short chain dehydrogenase; Provisional; Region: PRK09072 1283330005095 classical (c) SDRs; Region: SDR_c; cd05233 1283330005096 NAD(P) binding site [chemical binding]; other site 1283330005097 active site 1283330005098 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1283330005099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330005100 active site 1283330005101 phosphorylation site [posttranslational modification] 1283330005102 intermolecular recognition site; other site 1283330005103 dimerization interface [polypeptide binding]; other site 1283330005104 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283330005105 DNA binding site [nucleotide binding] 1283330005106 sensor protein QseC; Provisional; Region: PRK10337 1283330005107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1283330005108 dimer interface [polypeptide binding]; other site 1283330005109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330005110 ATP binding site [chemical binding]; other site 1283330005111 Mg2+ binding site [ion binding]; other site 1283330005112 G-X-G motif; other site 1283330005113 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1283330005114 hypothetical protein; Provisional; Region: PRK00295 1283330005115 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1283330005116 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1283330005117 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1283330005118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330005119 dimer interface [polypeptide binding]; other site 1283330005120 conserved gate region; other site 1283330005121 putative PBP binding loops; other site 1283330005122 ABC-ATPase subunit interface; other site 1283330005123 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1283330005124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330005125 dimer interface [polypeptide binding]; other site 1283330005126 conserved gate region; other site 1283330005127 putative PBP binding loops; other site 1283330005128 ABC-ATPase subunit interface; other site 1283330005129 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1283330005130 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283330005131 Walker A/P-loop; other site 1283330005132 ATP binding site [chemical binding]; other site 1283330005133 Q-loop/lid; other site 1283330005134 ABC transporter signature motif; other site 1283330005135 Walker B; other site 1283330005136 D-loop; other site 1283330005137 H-loop/switch region; other site 1283330005138 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283330005139 Walker A/P-loop; other site 1283330005140 ATP binding site [chemical binding]; other site 1283330005141 Q-loop/lid; other site 1283330005142 ABC transporter signature motif; other site 1283330005143 Walker B; other site 1283330005144 D-loop; other site 1283330005145 H-loop/switch region; other site 1283330005146 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1283330005147 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 1283330005148 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1283330005149 aminopeptidase N; Provisional; Region: pepN; PRK14015 1283330005150 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1283330005151 active site 1283330005152 Zn binding site [ion binding]; other site 1283330005153 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1283330005154 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1283330005155 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1283330005156 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283330005157 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1283330005158 putative active site [active] 1283330005159 putative NTP binding site [chemical binding]; other site 1283330005160 putative nucleic acid binding site [nucleotide binding]; other site 1283330005161 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1283330005162 Protein of unknown function (DUF3144); Region: DUF3144; pfam11342 1283330005163 Oxygen tolerance; Region: BatD; pfam13584 1283330005164 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1283330005165 metal ion-dependent adhesion site (MIDAS); other site 1283330005166 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1283330005167 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1283330005168 metal ion-dependent adhesion site (MIDAS); other site 1283330005169 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 1283330005170 Protein of unknown function DUF58; Region: DUF58; pfam01882 1283330005171 MoxR-like ATPases [General function prediction only]; Region: COG0714 1283330005172 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 1283330005173 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 1283330005174 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 1283330005175 Predicted integral membrane protein [Function unknown]; Region: COG0392 1283330005176 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1283330005177 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1283330005178 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1283330005179 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 1283330005180 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1283330005181 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1283330005182 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1283330005183 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1283330005184 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1283330005185 quinone interaction residues [chemical binding]; other site 1283330005186 active site 1283330005187 catalytic residues [active] 1283330005188 FMN binding site [chemical binding]; other site 1283330005189 substrate binding site [chemical binding]; other site 1283330005190 Ribosome modulation factor; Region: RMF; cl01207 1283330005191 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1283330005192 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1283330005193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1283330005194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330005195 S-adenosylmethionine binding site [chemical binding]; other site 1283330005196 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1283330005197 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1283330005198 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1283330005199 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1283330005200 Zn2+ binding site [ion binding]; other site 1283330005201 Mg2+ binding site [ion binding]; other site 1283330005202 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1283330005203 Predicted membrane protein [Function unknown]; Region: COG5393 1283330005204 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 1283330005205 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1283330005206 Staphylococcal nuclease homologues; Region: SNc; smart00318 1283330005207 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1283330005208 Catalytic site; other site 1283330005209 Dienelactone hydrolase family; Region: DLH; pfam01738 1283330005210 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330005211 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1283330005212 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1283330005213 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1283330005214 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1283330005215 substrate binding site [chemical binding]; other site 1283330005216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330005217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330005218 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1283330005219 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1283330005220 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1283330005221 helicase 45; Provisional; Region: PTZ00424 1283330005222 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1283330005223 ATP binding site [chemical binding]; other site 1283330005224 Mg++ binding site [ion binding]; other site 1283330005225 motif III; other site 1283330005226 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283330005227 nucleotide binding region [chemical binding]; other site 1283330005228 ATP-binding site [chemical binding]; other site 1283330005229 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1283330005230 Methyltransferase domain; Region: Methyltransf_25; pfam13649 1283330005231 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1283330005232 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1283330005233 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1283330005234 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283330005235 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1283330005236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330005237 Walker A/P-loop; other site 1283330005238 ATP binding site [chemical binding]; other site 1283330005239 Q-loop/lid; other site 1283330005240 ABC transporter signature motif; other site 1283330005241 Walker B; other site 1283330005242 D-loop; other site 1283330005243 H-loop/switch region; other site 1283330005244 LysR family transcriptional regulator; Provisional; Region: PRK14997 1283330005245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330005246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283330005247 dimerization interface [polypeptide binding]; other site 1283330005248 heat shock protein 90; Provisional; Region: PRK05218 1283330005249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330005250 ATP binding site [chemical binding]; other site 1283330005251 Mg2+ binding site [ion binding]; other site 1283330005252 G-X-G motif; other site 1283330005253 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1283330005254 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1283330005255 dimer interface [polypeptide binding]; other site 1283330005256 active site 1283330005257 metal binding site [ion binding]; metal-binding site 1283330005258 glutathione binding site [chemical binding]; other site 1283330005259 endonuclease III; Provisional; Region: PRK10702 1283330005260 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1283330005261 minor groove reading motif; other site 1283330005262 helix-hairpin-helix signature motif; other site 1283330005263 substrate binding pocket [chemical binding]; other site 1283330005264 active site 1283330005265 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1283330005266 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1283330005267 FMN-binding domain; Region: FMN_bind; cl01081 1283330005268 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1283330005269 electron transport complex protein RnfC; Provisional; Region: PRK05035 1283330005270 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1283330005271 SLBB domain; Region: SLBB; pfam10531 1283330005272 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1283330005273 ferredoxin; Provisional; Region: PRK08764 1283330005274 Putative Fe-S cluster; Region: FeS; cl17515 1283330005275 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1283330005276 electron transport complex protein RsxA; Provisional; Region: PRK05151 1283330005277 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1283330005278 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1283330005279 active site 1283330005280 HIGH motif; other site 1283330005281 KMSKS motif; other site 1283330005282 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1283330005283 tRNA binding surface [nucleotide binding]; other site 1283330005284 anticodon binding site; other site 1283330005285 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1283330005286 dimer interface [polypeptide binding]; other site 1283330005287 putative tRNA-binding site [nucleotide binding]; other site 1283330005288 antiporter inner membrane protein; Provisional; Region: PRK11670 1283330005289 Domain of unknown function DUF59; Region: DUF59; pfam01883 1283330005290 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1283330005291 Walker A motif; other site 1283330005292 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1283330005293 trimer interface [polypeptide binding]; other site 1283330005294 active site 1283330005295 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283330005296 active site 1283330005297 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1283330005298 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1283330005299 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1283330005300 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1283330005301 active site 1283330005302 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 1283330005303 Water Stress and Hypersensitive response; Region: WHy; smart00769 1283330005304 hypothetical protein; Provisional; Region: PRK00183 1283330005305 SEC-C motif; Region: SEC-C; pfam02810 1283330005306 SEC-C motif; Region: SEC-C; pfam02810 1283330005307 Predicted integral membrane protein [Function unknown]; Region: COG5615 1283330005308 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1283330005309 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1283330005310 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1283330005311 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1283330005312 Beta-lactamase; Region: Beta-lactamase; pfam00144 1283330005313 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1283330005314 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283330005315 ligand binding site [chemical binding]; other site 1283330005316 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1283330005317 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1283330005318 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1283330005319 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1283330005320 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 1283330005321 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1283330005322 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1283330005323 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1283330005324 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 1283330005325 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 1283330005326 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1283330005327 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1283330005328 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 1283330005329 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1283330005330 Predicted membrane protein [Function unknown]; Region: COG3650 1283330005331 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1283330005332 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1283330005333 Walker A/P-loop; other site 1283330005334 ATP binding site [chemical binding]; other site 1283330005335 Q-loop/lid; other site 1283330005336 ABC transporter signature motif; other site 1283330005337 Walker B; other site 1283330005338 D-loop; other site 1283330005339 H-loop/switch region; other site 1283330005340 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1283330005341 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1283330005342 Walker A/P-loop; other site 1283330005343 ATP binding site [chemical binding]; other site 1283330005344 Q-loop/lid; other site 1283330005345 ABC transporter signature motif; other site 1283330005346 Walker B; other site 1283330005347 D-loop; other site 1283330005348 H-loop/switch region; other site 1283330005349 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1283330005350 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1283330005351 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1283330005352 TM-ABC transporter signature motif; other site 1283330005353 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1283330005354 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1283330005355 TM-ABC transporter signature motif; other site 1283330005356 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1283330005357 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1283330005358 dimerization interface [polypeptide binding]; other site 1283330005359 ligand binding site [chemical binding]; other site 1283330005360 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 1283330005361 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 1283330005362 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1283330005363 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1283330005364 alpha subunit interaction interface [polypeptide binding]; other site 1283330005365 Walker A motif; other site 1283330005366 ATP binding site [chemical binding]; other site 1283330005367 Walker B motif; other site 1283330005368 inhibitor binding site; inhibition site 1283330005369 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1283330005370 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 1283330005371 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1283330005372 gamma subunit interface [polypeptide binding]; other site 1283330005373 epsilon subunit interface [polypeptide binding]; other site 1283330005374 LBP interface [polypeptide binding]; other site 1283330005375 F0F1 ATP synthase subunit A; Provisional; Region: PRK13421 1283330005376 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1283330005377 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 1283330005378 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1283330005379 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1283330005380 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 1283330005381 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1283330005382 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1283330005383 Walker A motif; other site 1283330005384 ATP binding site [chemical binding]; other site 1283330005385 Walker B motif; other site 1283330005386 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1283330005387 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1283330005388 delta subunit interface [polypeptide binding]; other site 1283330005389 core domain interface [polypeptide binding]; other site 1283330005390 epsilon subunit interface [polypeptide binding]; other site 1283330005391 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1283330005392 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1283330005393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330005394 dimer interface [polypeptide binding]; other site 1283330005395 conserved gate region; other site 1283330005396 putative PBP binding loops; other site 1283330005397 ABC-ATPase subunit interface; other site 1283330005398 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1283330005399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330005400 Walker A/P-loop; other site 1283330005401 ATP binding site [chemical binding]; other site 1283330005402 Q-loop/lid; other site 1283330005403 ABC transporter signature motif; other site 1283330005404 Walker B; other site 1283330005405 D-loop; other site 1283330005406 H-loop/switch region; other site 1283330005407 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1283330005408 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1283330005409 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1283330005410 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1283330005411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330005412 Walker A motif; other site 1283330005413 ATP binding site [chemical binding]; other site 1283330005414 Walker B motif; other site 1283330005415 arginine finger; other site 1283330005416 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1283330005417 hypothetical protein; Validated; Region: PRK00153 1283330005418 recombination protein RecR; Reviewed; Region: recR; PRK00076 1283330005419 RecR protein; Region: RecR; pfam02132 1283330005420 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1283330005421 putative active site [active] 1283330005422 putative metal-binding site [ion binding]; other site 1283330005423 tetramer interface [polypeptide binding]; other site 1283330005424 Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600 1283330005425 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1283330005426 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1283330005427 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1283330005428 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1283330005429 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1283330005430 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1283330005431 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1283330005432 ligand binding site [chemical binding]; other site 1283330005433 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1283330005434 putative switch regulator; other site 1283330005435 non-specific DNA interactions [nucleotide binding]; other site 1283330005436 DNA binding site [nucleotide binding] 1283330005437 sequence specific DNA binding site [nucleotide binding]; other site 1283330005438 putative cAMP binding site [chemical binding]; other site 1283330005439 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1283330005440 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283330005441 FeS/SAM binding site; other site 1283330005442 HemN C-terminal domain; Region: HemN_C; pfam06969 1283330005443 Uncharacterized conserved protein [Function unknown]; Region: COG2836 1283330005444 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 1283330005445 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1283330005446 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1283330005447 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1283330005448 metal-binding site [ion binding] 1283330005449 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1283330005450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330005451 motif II; other site 1283330005452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 1283330005453 FixH; Region: FixH; pfam05751 1283330005454 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1283330005455 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1283330005456 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1283330005457 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1283330005458 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1283330005459 Cytochrome c; Region: Cytochrom_C; pfam00034 1283330005460 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1283330005461 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1283330005462 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1283330005463 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1283330005464 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1283330005465 Low-spin heme binding site [chemical binding]; other site 1283330005466 Putative water exit pathway; other site 1283330005467 Binuclear center (active site) [active] 1283330005468 Putative proton exit pathway; other site 1283330005469 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1283330005470 aconitate hydratase; Validated; Region: PRK09277 1283330005471 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1283330005472 substrate binding site [chemical binding]; other site 1283330005473 ligand binding site [chemical binding]; other site 1283330005474 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1283330005475 substrate binding site [chemical binding]; other site 1283330005476 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1283330005477 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1283330005478 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1283330005479 CPxP motif; other site 1283330005480 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1283330005481 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1283330005482 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283330005483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330005484 homodimer interface [polypeptide binding]; other site 1283330005485 catalytic residue [active] 1283330005486 excinuclease ABC subunit B; Provisional; Region: PRK05298 1283330005487 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283330005488 ATP binding site [chemical binding]; other site 1283330005489 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283330005490 nucleotide binding region [chemical binding]; other site 1283330005491 ATP-binding site [chemical binding]; other site 1283330005492 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1283330005493 UvrB/uvrC motif; Region: UVR; pfam02151 1283330005494 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1283330005495 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1283330005496 HIGH motif; other site 1283330005497 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1283330005498 active site 1283330005499 KMSKS motif; other site 1283330005500 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1283330005501 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1283330005502 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1283330005503 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1283330005504 tetramer interface [polypeptide binding]; other site 1283330005505 active site 1283330005506 Mg2+/Mn2+ binding site [ion binding]; other site 1283330005507 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1283330005508 metal binding site [ion binding]; metal-binding site 1283330005509 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1283330005510 putative active site [active] 1283330005511 putative metal binding site [ion binding]; other site 1283330005512 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1283330005513 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 1283330005514 probable active site [active] 1283330005515 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1283330005516 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1283330005517 putative dimer interface [polypeptide binding]; other site 1283330005518 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1283330005519 active site 1283330005520 nucleophile elbow; other site 1283330005521 Patatin phospholipase; Region: DUF3734; pfam12536 1283330005522 short chain dehydrogenase; Provisional; Region: PRK07326 1283330005523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330005524 NAD(P) binding site [chemical binding]; other site 1283330005525 active site 1283330005526 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1283330005527 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1283330005528 Bacterial transcriptional regulator; Region: IclR; pfam01614 1283330005529 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1283330005530 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1283330005531 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1283330005532 shikimate binding site; other site 1283330005533 NAD(P) binding site [chemical binding]; other site 1283330005534 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 1283330005535 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1283330005536 NIPSNAP; Region: NIPSNAP; pfam07978 1283330005537 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 1283330005538 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1283330005539 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1283330005540 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1283330005541 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1283330005542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330005543 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1283330005544 L-idonate 5-dehydrogenase; Region: PLN02702 1283330005545 inhibitor binding site; inhibition site 1283330005546 catalytic Zn binding site [ion binding]; other site 1283330005547 structural Zn binding site [ion binding]; other site 1283330005548 NADP binding site [chemical binding]; other site 1283330005549 tetramer interface [polypeptide binding]; other site 1283330005550 polyol permease family; Region: 2A0118; TIGR00897 1283330005551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330005552 putative substrate translocation pore; other site 1283330005553 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1283330005554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330005555 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1283330005556 classical (c) SDRs; Region: SDR_c; cd05233 1283330005557 NAD(P) binding site [chemical binding]; other site 1283330005558 active site 1283330005559 putative succinate dehydrogenase; Reviewed; Region: PRK12842 1283330005560 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1283330005561 NIPSNAP; Region: NIPSNAP; pfam07978 1283330005562 benzoate transport; Region: 2A0115; TIGR00895 1283330005563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330005564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330005565 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1283330005566 putative active site [active] 1283330005567 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1283330005568 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1283330005569 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1283330005570 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283330005571 putative NTP binding site [chemical binding]; other site 1283330005572 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1283330005573 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1283330005574 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1283330005575 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1283330005576 active site 1283330005577 dimer interface [polypeptide binding]; other site 1283330005578 motif 1; other site 1283330005579 motif 2; other site 1283330005580 motif 3; other site 1283330005581 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1283330005582 anticodon binding site; other site 1283330005583 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1283330005584 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1283330005585 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1283330005586 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1283330005587 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1283330005588 23S rRNA binding site [nucleotide binding]; other site 1283330005589 L21 binding site [polypeptide binding]; other site 1283330005590 L13 binding site [polypeptide binding]; other site 1283330005591 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1283330005592 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1283330005593 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1283330005594 dimer interface [polypeptide binding]; other site 1283330005595 motif 1; other site 1283330005596 active site 1283330005597 motif 2; other site 1283330005598 motif 3; other site 1283330005599 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1283330005600 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1283330005601 putative tRNA-binding site [nucleotide binding]; other site 1283330005602 B3/4 domain; Region: B3_4; pfam03483 1283330005603 tRNA synthetase B5 domain; Region: B5; smart00874 1283330005604 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1283330005605 dimer interface [polypeptide binding]; other site 1283330005606 motif 1; other site 1283330005607 motif 3; other site 1283330005608 motif 2; other site 1283330005609 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1283330005610 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1283330005611 IHF dimer interface [polypeptide binding]; other site 1283330005612 IHF - DNA interface [nucleotide binding]; other site 1283330005613 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1283330005614 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1283330005615 active site 1283330005616 DNA binding site [nucleotide binding] 1283330005617 Int/Topo IB signature motif; other site 1283330005618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330005619 non-specific DNA binding site [nucleotide binding]; other site 1283330005620 salt bridge; other site 1283330005621 sequence-specific DNA binding site [nucleotide binding]; other site 1283330005622 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1283330005623 putative transposase OrfB; Reviewed; Region: PHA02517 1283330005624 HTH-like domain; Region: HTH_21; pfam13276 1283330005625 Integrase core domain; Region: rve; pfam00665 1283330005626 Integrase core domain; Region: rve_3; pfam13683 1283330005627 Transposase; Region: HTH_Tnp_1; cl17663 1283330005628 VacJ like lipoprotein; Region: VacJ; cl01073 1283330005629 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1283330005630 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1283330005631 TPP-binding site; other site 1283330005632 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1283330005633 PYR/PP interface [polypeptide binding]; other site 1283330005634 dimer interface [polypeptide binding]; other site 1283330005635 TPP binding site [chemical binding]; other site 1283330005636 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1283330005637 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1283330005638 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1283330005639 substrate binding pocket [chemical binding]; other site 1283330005640 chain length determination region; other site 1283330005641 substrate-Mg2+ binding site; other site 1283330005642 catalytic residues [active] 1283330005643 aspartate-rich region 1; other site 1283330005644 active site lid residues [active] 1283330005645 aspartate-rich region 2; other site 1283330005646 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1283330005647 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1283330005648 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1283330005649 active site 1283330005650 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 1283330005651 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283330005652 FeS/SAM binding site; other site 1283330005653 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 1283330005654 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1283330005655 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1283330005656 active site 1283330005657 metal binding site [ion binding]; metal-binding site 1283330005658 nudix motif; other site 1283330005659 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 1283330005660 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 1283330005661 ligand binding site; other site 1283330005662 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 1283330005663 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1283330005664 B12 binding site [chemical binding]; other site 1283330005665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283330005666 FeS/SAM binding site; other site 1283330005667 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 1283330005668 putative homodimer interface [polypeptide binding]; other site 1283330005669 putative active site [active] 1283330005670 YdjC motif; other site 1283330005671 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1283330005672 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330005673 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330005674 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1283330005675 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1283330005676 putative NADP binding site [chemical binding]; other site 1283330005677 putative substrate binding site [chemical binding]; other site 1283330005678 active site 1283330005679 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 1283330005680 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1283330005681 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1283330005682 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1283330005683 Active site cavity [active] 1283330005684 catalytic acid [active] 1283330005685 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1283330005686 active site lid residues [active] 1283330005687 substrate binding pocket [chemical binding]; other site 1283330005688 catalytic residues [active] 1283330005689 substrate-Mg2+ binding site; other site 1283330005690 aspartate-rich region 1; other site 1283330005691 aspartate-rich region 2; other site 1283330005692 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330005693 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330005694 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 1283330005695 putative substrate binding pocket [chemical binding]; other site 1283330005696 putative dimerization interface [polypeptide binding]; other site 1283330005697 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1283330005698 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1283330005699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330005700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330005701 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283330005702 dimerization interface [polypeptide binding]; other site 1283330005703 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1283330005704 active site 1283330005705 catalytic triad [active] 1283330005706 oxyanion hole [active] 1283330005707 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1283330005708 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1283330005709 FMN binding site [chemical binding]; other site 1283330005710 active site 1283330005711 substrate binding site [chemical binding]; other site 1283330005712 catalytic residue [active] 1283330005713 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283330005714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330005715 putative substrate translocation pore; other site 1283330005716 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 1283330005717 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 1283330005718 TPR repeat; Region: TPR_11; pfam13414 1283330005719 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 1283330005720 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1283330005721 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1283330005722 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1283330005723 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1283330005724 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1283330005725 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 1283330005726 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 1283330005727 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1283330005728 GAF domain; Region: GAF; pfam01590 1283330005729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330005730 Walker A motif; other site 1283330005731 ATP binding site [chemical binding]; other site 1283330005732 Walker B motif; other site 1283330005733 arginine finger; other site 1283330005734 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330005735 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1283330005736 Protein phosphatase 2C; Region: PP2C; pfam00481 1283330005737 active site 1283330005738 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1283330005739 active site residue [active] 1283330005740 serine O-acetyltransferase; Region: cysE; TIGR01172 1283330005741 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1283330005742 trimer interface [polypeptide binding]; other site 1283330005743 active site 1283330005744 substrate binding site [chemical binding]; other site 1283330005745 CoA binding site [chemical binding]; other site 1283330005746 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1283330005747 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1283330005748 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283330005749 catalytic residue [active] 1283330005750 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1283330005751 metal-binding site [ion binding] 1283330005752 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1283330005753 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1283330005754 metal-binding site [ion binding] 1283330005755 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1283330005756 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330005757 motif II; other site 1283330005758 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283330005759 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330005760 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330005761 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1283330005762 Integrase core domain; Region: rve; pfam00665 1283330005763 Integrase core domain; Region: rve_3; pfam13683 1283330005764 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1283330005765 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283330005766 substrate binding site [chemical binding]; other site 1283330005767 oxyanion hole (OAH) forming residues; other site 1283330005768 trimer interface [polypeptide binding]; other site 1283330005769 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1283330005770 Predicted membrane protein [Function unknown]; Region: COG3748 1283330005771 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1283330005772 Cytochrome c; Region: Cytochrom_C; pfam00034 1283330005773 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1283330005774 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1283330005775 allantoicase; Provisional; Region: PRK13257 1283330005776 Allantoicase repeat; Region: Allantoicase; pfam03561 1283330005777 Allantoicase repeat; Region: Allantoicase; pfam03561 1283330005778 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 1283330005779 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1283330005780 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1283330005781 active site 1283330005782 catalytic site [active] 1283330005783 tetramer interface [polypeptide binding]; other site 1283330005784 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1283330005785 active site 1283330005786 homotetramer interface [polypeptide binding]; other site 1283330005787 Condensation domain; Region: Condensation; pfam00668 1283330005788 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1283330005789 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1283330005790 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 1283330005791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330005792 NAD(P) binding site [chemical binding]; other site 1283330005793 active site 1283330005794 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1283330005795 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283330005796 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283330005797 acyl-activating enzyme (AAE) consensus motif; other site 1283330005798 AMP binding site [chemical binding]; other site 1283330005799 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330005800 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1283330005801 Isochorismatase family; Region: Isochorismatase; pfam00857 1283330005802 active site 1283330005803 hydrophobic substrate binding pocket; other site 1283330005804 conserved cis-peptide bond; other site 1283330005805 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1283330005806 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1283330005807 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1283330005808 acyl-activating enzyme (AAE) consensus motif; other site 1283330005809 active site 1283330005810 AMP binding site [chemical binding]; other site 1283330005811 substrate binding site [chemical binding]; other site 1283330005812 isochorismate synthase DhbC; Validated; Region: PRK06923 1283330005813 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1283330005814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330005815 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283330005816 putative substrate translocation pore; other site 1283330005817 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1283330005818 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1283330005819 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1283330005820 tetramer interface [polypeptide binding]; other site 1283330005821 active site 1283330005822 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1283330005823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1283330005824 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330005825 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1283330005826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330005827 Walker A/P-loop; other site 1283330005828 ATP binding site [chemical binding]; other site 1283330005829 Q-loop/lid; other site 1283330005830 ABC transporter signature motif; other site 1283330005831 Walker B; other site 1283330005832 D-loop; other site 1283330005833 H-loop/switch region; other site 1283330005834 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1283330005835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330005836 dimer interface [polypeptide binding]; other site 1283330005837 conserved gate region; other site 1283330005838 putative PBP binding loops; other site 1283330005839 ABC-ATPase subunit interface; other site 1283330005840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330005841 dimer interface [polypeptide binding]; other site 1283330005842 conserved gate region; other site 1283330005843 putative PBP binding loops; other site 1283330005844 ABC-ATPase subunit interface; other site 1283330005845 hypothetical protein; Validated; Region: PRK07121 1283330005846 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1283330005847 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1283330005848 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1283330005849 active site 1283330005850 iron coordination sites [ion binding]; other site 1283330005851 substrate binding pocket [chemical binding]; other site 1283330005852 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283330005853 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283330005854 active site 1283330005855 non-prolyl cis peptide bond; other site 1283330005856 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1283330005857 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1283330005858 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1283330005859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330005860 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1283330005861 putative dimerization interface [polypeptide binding]; other site 1283330005862 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1283330005863 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330005864 substrate binding pocket [chemical binding]; other site 1283330005865 membrane-bound complex binding site; other site 1283330005866 hinge residues; other site 1283330005867 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1283330005868 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1283330005869 FAD binding domain; Region: FAD_binding_4; pfam01565 1283330005870 aspartate aminotransferase; Provisional; Region: PRK06107 1283330005871 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283330005872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330005873 homodimer interface [polypeptide binding]; other site 1283330005874 catalytic residue [active] 1283330005875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330005876 dimer interface [polypeptide binding]; other site 1283330005877 conserved gate region; other site 1283330005878 putative PBP binding loops; other site 1283330005879 ABC-ATPase subunit interface; other site 1283330005880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330005881 dimer interface [polypeptide binding]; other site 1283330005882 conserved gate region; other site 1283330005883 putative PBP binding loops; other site 1283330005884 ABC-ATPase subunit interface; other site 1283330005885 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1283330005886 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1283330005887 Walker A/P-loop; other site 1283330005888 ATP binding site [chemical binding]; other site 1283330005889 Q-loop/lid; other site 1283330005890 ABC transporter signature motif; other site 1283330005891 Walker B; other site 1283330005892 D-loop; other site 1283330005893 H-loop/switch region; other site 1283330005894 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1283330005895 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1283330005896 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1283330005897 C-terminal domain interface [polypeptide binding]; other site 1283330005898 GSH binding site (G-site) [chemical binding]; other site 1283330005899 dimer interface [polypeptide binding]; other site 1283330005900 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1283330005901 N-terminal domain interface [polypeptide binding]; other site 1283330005902 dimer interface [polypeptide binding]; other site 1283330005903 substrate binding pocket (H-site) [chemical binding]; other site 1283330005904 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1283330005905 active site residue [active] 1283330005906 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 1283330005907 active site residue [active] 1283330005908 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1283330005909 active site residue [active] 1283330005910 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1283330005911 active site residue [active] 1283330005912 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1283330005913 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1283330005914 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283330005915 catalytic residue [active] 1283330005916 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283330005917 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283330005918 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330005919 N-terminal plug; other site 1283330005920 ligand-binding site [chemical binding]; other site 1283330005921 fec operon regulator FecR; Reviewed; Region: PRK09774 1283330005922 FecR protein; Region: FecR; pfam04773 1283330005923 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1283330005924 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330005925 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330005926 DNA binding residues [nucleotide binding] 1283330005927 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1283330005928 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1283330005929 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1283330005930 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_15; cd12180 1283330005931 putative ligand binding site [chemical binding]; other site 1283330005932 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1283330005933 putative NAD binding site [chemical binding]; other site 1283330005934 catalytic site [active] 1283330005935 aldolase II superfamily protein; Provisional; Region: PRK07044 1283330005936 intersubunit interface [polypeptide binding]; other site 1283330005937 active site 1283330005938 Zn2+ binding site [ion binding]; other site 1283330005939 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283330005940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330005941 dimer interface [polypeptide binding]; other site 1283330005942 conserved gate region; other site 1283330005943 putative PBP binding loops; other site 1283330005944 ABC-ATPase subunit interface; other site 1283330005945 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283330005946 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283330005947 Walker A/P-loop; other site 1283330005948 ATP binding site [chemical binding]; other site 1283330005949 Q-loop/lid; other site 1283330005950 ABC transporter signature motif; other site 1283330005951 Walker B; other site 1283330005952 D-loop; other site 1283330005953 H-loop/switch region; other site 1283330005954 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1283330005955 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330005956 N-terminal plug; other site 1283330005957 ligand-binding site [chemical binding]; other site 1283330005958 NMT1/THI5 like; Region: NMT1; pfam09084 1283330005959 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330005960 membrane-bound complex binding site; other site 1283330005961 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283330005962 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283330005963 active site 1283330005964 non-prolyl cis peptide bond; other site 1283330005965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330005966 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330005967 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283330005968 dimerization interface [polypeptide binding]; other site 1283330005969 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1283330005970 TolR protein; Region: tolR; TIGR02801 1283330005971 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1283330005972 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1283330005973 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1283330005974 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283330005975 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330005976 substrate binding pocket [chemical binding]; other site 1283330005977 membrane-bound complex binding site; other site 1283330005978 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283330005979 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283330005980 active site 1283330005981 catalytic tetrad [active] 1283330005982 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283330005983 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283330005984 active site 1283330005985 non-prolyl cis peptide bond; other site 1283330005986 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330005987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330005988 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1283330005989 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283330005990 DNA binding site [nucleotide binding] 1283330005991 domain linker motif; other site 1283330005992 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1283330005993 putative ligand binding site [chemical binding]; other site 1283330005994 putative dimerization interface [polypeptide binding]; other site 1283330005995 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1283330005996 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1283330005997 RES domain; Region: RES; smart00953 1283330005998 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1283330005999 TolR protein; Region: tolR; TIGR02801 1283330006000 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1283330006001 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1283330006002 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1283330006003 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1283330006004 active site 1283330006005 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1283330006006 dimer interface [polypeptide binding]; other site 1283330006007 non-prolyl cis peptide bond; other site 1283330006008 insertion regions; other site 1283330006009 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1283330006010 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1283330006011 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1283330006012 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1283330006013 putative catalytic residues [active] 1283330006014 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283330006015 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283330006016 active site 1283330006017 non-prolyl cis peptide bond; other site 1283330006018 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1283330006019 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1283330006020 FMN binding site [chemical binding]; other site 1283330006021 active site 1283330006022 substrate binding site [chemical binding]; other site 1283330006023 catalytic residue [active] 1283330006024 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283330006025 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330006026 membrane-bound complex binding site; other site 1283330006027 Ferredoxin [Energy production and conversion]; Region: COG1146 1283330006028 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1283330006029 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1283330006030 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1283330006031 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1283330006032 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1283330006033 molybdopterin cofactor binding site [chemical binding]; other site 1283330006034 substrate binding site [chemical binding]; other site 1283330006035 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1283330006036 molybdopterin cofactor binding site; other site 1283330006037 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1283330006038 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1283330006039 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1283330006040 substrate binding pocket [chemical binding]; other site 1283330006041 active site 1283330006042 iron coordination sites [ion binding]; other site 1283330006043 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1283330006044 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283330006045 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283330006046 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283330006047 Walker A/P-loop; other site 1283330006048 ATP binding site [chemical binding]; other site 1283330006049 Q-loop/lid; other site 1283330006050 ABC transporter signature motif; other site 1283330006051 Walker B; other site 1283330006052 D-loop; other site 1283330006053 H-loop/switch region; other site 1283330006054 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283330006055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330006056 dimer interface [polypeptide binding]; other site 1283330006057 conserved gate region; other site 1283330006058 putative PBP binding loops; other site 1283330006059 ABC-ATPase subunit interface; other site 1283330006060 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1283330006061 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1283330006062 ligand binding site [chemical binding]; other site 1283330006063 flexible hinge region; other site 1283330006064 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1283330006065 non-specific DNA interactions [nucleotide binding]; other site 1283330006066 DNA binding site [nucleotide binding] 1283330006067 sequence specific DNA binding site [nucleotide binding]; other site 1283330006068 putative cAMP binding site [chemical binding]; other site 1283330006069 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283330006070 trimer interface; other site 1283330006071 sugar binding site [chemical binding]; other site 1283330006072 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1283330006073 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 1283330006074 putative NAD(P) binding site [chemical binding]; other site 1283330006075 catalytic Zn binding site [ion binding]; other site 1283330006076 structural Zn binding site [ion binding]; other site 1283330006077 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1283330006078 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1283330006079 tetrameric interface [polypeptide binding]; other site 1283330006080 activator binding site; other site 1283330006081 NADP binding site [chemical binding]; other site 1283330006082 substrate binding site [chemical binding]; other site 1283330006083 catalytic residues [active] 1283330006084 DAK2 domain; Region: Dak2; pfam02734 1283330006085 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1283330006086 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1283330006087 short chain dehydrogenase; Provisional; Region: PRK06841 1283330006088 classical (c) SDRs; Region: SDR_c; cd05233 1283330006089 NAD(P) binding site [chemical binding]; other site 1283330006090 active site 1283330006091 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1283330006092 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1283330006093 putative ligand binding site [chemical binding]; other site 1283330006094 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1283330006095 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1283330006096 TM-ABC transporter signature motif; other site 1283330006097 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1283330006098 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1283330006099 Walker A/P-loop; other site 1283330006100 ATP binding site [chemical binding]; other site 1283330006101 Q-loop/lid; other site 1283330006102 ABC transporter signature motif; other site 1283330006103 Walker B; other site 1283330006104 D-loop; other site 1283330006105 H-loop/switch region; other site 1283330006106 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1283330006107 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1283330006108 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1283330006109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330006110 motif I; other site 1283330006111 motif II; other site 1283330006112 transaldolase-like protein; Provisional; Region: PTZ00411 1283330006113 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1283330006114 active site 1283330006115 dimer interface [polypeptide binding]; other site 1283330006116 catalytic residue [active] 1283330006117 transketolase; Reviewed; Region: PRK12753 1283330006118 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1283330006119 TPP-binding site [chemical binding]; other site 1283330006120 dimer interface [polypeptide binding]; other site 1283330006121 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1283330006122 PYR/PP interface [polypeptide binding]; other site 1283330006123 dimer interface [polypeptide binding]; other site 1283330006124 TPP binding site [chemical binding]; other site 1283330006125 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1283330006126 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1283330006127 active site 1283330006128 dimer interface [polypeptide binding]; other site 1283330006129 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1283330006130 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1283330006131 pyruvate kinase; Provisional; Region: PRK05826 1283330006132 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1283330006133 domain interfaces; other site 1283330006134 active site 1283330006135 enolase; Provisional; Region: eno; PRK00077 1283330006136 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1283330006137 dimer interface [polypeptide binding]; other site 1283330006138 metal binding site [ion binding]; metal-binding site 1283330006139 substrate binding pocket [chemical binding]; other site 1283330006140 PAS domain; Region: PAS_9; pfam13426 1283330006141 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330006142 putative active site [active] 1283330006143 heme pocket [chemical binding]; other site 1283330006144 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1283330006145 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1283330006146 DNA binding residues [nucleotide binding] 1283330006147 dimerization interface [polypeptide binding]; other site 1283330006148 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 1283330006149 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1283330006150 active site 1283330006151 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1283330006152 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1283330006153 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1283330006154 acyl-activating enzyme (AAE) consensus motif; other site 1283330006155 acyl-activating enzyme (AAE) consensus motif; other site 1283330006156 putative AMP binding site [chemical binding]; other site 1283330006157 putative active site [active] 1283330006158 putative CoA binding site [chemical binding]; other site 1283330006159 guanine deaminase; Provisional; Region: PRK09228 1283330006160 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1283330006161 active site 1283330006162 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1283330006163 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1283330006164 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1283330006165 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1283330006166 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1283330006167 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283330006168 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1283330006169 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283330006170 catalytic loop [active] 1283330006171 iron binding site [ion binding]; other site 1283330006172 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1283330006173 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1283330006174 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1283330006175 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1283330006176 active site 1283330006177 purine riboside binding site [chemical binding]; other site 1283330006178 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283330006179 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330006180 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330006181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1283330006182 Integrase core domain; Region: rve; pfam00665 1283330006183 Integrase core domain; Region: rve_3; pfam13683 1283330006184 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1283330006185 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1283330006186 active site 1283330006187 iron coordination sites [ion binding]; other site 1283330006188 substrate binding pocket [chemical binding]; other site 1283330006189 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1283330006190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330006191 Walker A motif; other site 1283330006192 ATP binding site [chemical binding]; other site 1283330006193 Walker B motif; other site 1283330006194 arginine finger; other site 1283330006195 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1283330006196 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1283330006197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1283330006198 Coenzyme A binding pocket [chemical binding]; other site 1283330006199 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283330006200 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283330006201 active site 1283330006202 catalytic tetrad [active] 1283330006203 glutathionine S-transferase; Provisional; Region: PRK10542 1283330006204 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1283330006205 C-terminal domain interface [polypeptide binding]; other site 1283330006206 GSH binding site (G-site) [chemical binding]; other site 1283330006207 dimer interface [polypeptide binding]; other site 1283330006208 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1283330006209 N-terminal domain interface [polypeptide binding]; other site 1283330006210 dimer interface [polypeptide binding]; other site 1283330006211 substrate binding pocket (H-site) [chemical binding]; other site 1283330006212 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1283330006213 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1283330006214 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283330006215 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283330006216 active site 1283330006217 non-prolyl cis peptide bond; other site 1283330006218 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283330006219 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330006220 substrate binding pocket [chemical binding]; other site 1283330006221 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1283330006222 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330006223 GntP family permease; Region: GntP_permease; pfam02447 1283330006224 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1283330006225 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1283330006226 AAA domain; Region: AAA_33; pfam13671 1283330006227 ATP-binding site [chemical binding]; other site 1283330006228 Gluconate-6-phosphate binding site [chemical binding]; other site 1283330006229 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1283330006230 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1283330006231 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283330006232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330006233 dimer interface [polypeptide binding]; other site 1283330006234 putative PBP binding loops; other site 1283330006235 ABC-ATPase subunit interface; other site 1283330006236 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283330006237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330006238 putative PBP binding loops; other site 1283330006239 ABC-ATPase subunit interface; other site 1283330006240 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283330006241 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283330006242 Walker A/P-loop; other site 1283330006243 ATP binding site [chemical binding]; other site 1283330006244 Q-loop/lid; other site 1283330006245 ABC transporter signature motif; other site 1283330006246 Walker B; other site 1283330006247 D-loop; other site 1283330006248 H-loop/switch region; other site 1283330006249 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330006250 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1283330006251 TOBE domain; Region: TOBE; cl01440 1283330006252 NAD-dependent deacetylase; Provisional; Region: PRK05333 1283330006253 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1283330006254 glutathionine S-transferase; Provisional; Region: PRK10542 1283330006255 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1283330006256 C-terminal domain interface [polypeptide binding]; other site 1283330006257 GSH binding site (G-site) [chemical binding]; other site 1283330006258 dimer interface [polypeptide binding]; other site 1283330006259 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1283330006260 dimer interface [polypeptide binding]; other site 1283330006261 N-terminal domain interface [polypeptide binding]; other site 1283330006262 substrate binding pocket (H-site) [chemical binding]; other site 1283330006263 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1283330006264 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330006265 N-terminal plug; other site 1283330006266 ligand-binding site [chemical binding]; other site 1283330006267 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283330006268 FecR protein; Region: FecR; pfam04773 1283330006269 RNA polymerase sigma factor; Provisional; Region: PRK12525 1283330006270 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330006271 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330006272 DNA binding residues [nucleotide binding] 1283330006273 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1283330006274 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 1283330006275 diiron binding motif [ion binding]; other site 1283330006276 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1283330006277 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1283330006278 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1283330006279 FeoA domain; Region: FeoA; pfam04023 1283330006280 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1283330006281 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1283330006282 G1 box; other site 1283330006283 GTP/Mg2+ binding site [chemical binding]; other site 1283330006284 Switch I region; other site 1283330006285 G2 box; other site 1283330006286 G3 box; other site 1283330006287 Switch II region; other site 1283330006288 G4 box; other site 1283330006289 G5 box; other site 1283330006290 Nucleoside recognition; Region: Gate; pfam07670 1283330006291 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1283330006292 FeoC like transcriptional regulator; Region: FeoC; pfam09012 1283330006293 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1283330006294 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1283330006295 dimerization interface [polypeptide binding]; other site 1283330006296 DPS ferroxidase diiron center [ion binding]; other site 1283330006297 ion pore; other site 1283330006298 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 1283330006299 PAS domain; Region: PAS_9; pfam13426 1283330006300 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330006301 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330006302 metal binding site [ion binding]; metal-binding site 1283330006303 active site 1283330006304 I-site; other site 1283330006305 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1283330006306 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1283330006307 inhibitor-cofactor binding pocket; inhibition site 1283330006308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330006309 catalytic residue [active] 1283330006310 Ion channel; Region: Ion_trans_2; pfam07885 1283330006311 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1283330006312 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330006313 N-terminal plug; other site 1283330006314 ligand-binding site [chemical binding]; other site 1283330006315 SdiA-regulated; Region: SdiA-regulated; pfam06977 1283330006316 SdiA-regulated; Region: SdiA-regulated; cd09971 1283330006317 putative active site [active] 1283330006318 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 1283330006319 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1283330006320 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1283330006321 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 1283330006322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1283330006323 Walker A motif; other site 1283330006324 ATP binding site [chemical binding]; other site 1283330006325 Walker B motif; other site 1283330006326 arginine finger; other site 1283330006327 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1283330006328 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1283330006329 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1283330006330 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1283330006331 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1283330006332 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1283330006333 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1283330006334 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1283330006335 CHAD domain; Region: CHAD; pfam05235 1283330006336 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1283330006337 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1283330006338 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1283330006339 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1283330006340 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 1283330006341 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1283330006342 active site 1283330006343 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330006344 substrate binding pocket [chemical binding]; other site 1283330006345 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1283330006346 membrane-bound complex binding site; other site 1283330006347 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1283330006348 hinge residues; other site 1283330006349 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1283330006350 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1283330006351 catalytic residue [active] 1283330006352 2'-5' RNA ligase; Provisional; Region: PRK15124 1283330006353 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1283330006354 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1283330006355 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1283330006356 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1283330006357 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1283330006358 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1283330006359 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1283330006360 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1283330006361 Walker A/P-loop; other site 1283330006362 ATP binding site [chemical binding]; other site 1283330006363 Q-loop/lid; other site 1283330006364 ABC transporter signature motif; other site 1283330006365 Walker B; other site 1283330006366 D-loop; other site 1283330006367 H-loop/switch region; other site 1283330006368 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1283330006369 active site 1283330006370 catalytic triad [active] 1283330006371 oxyanion hole [active] 1283330006372 switch loop; other site 1283330006373 L,D-transpeptidase; Provisional; Region: PRK10260 1283330006374 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1283330006375 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1283330006376 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1283330006377 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1283330006378 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1283330006379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330006380 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 1283330006381 substrate binding site [chemical binding]; other site 1283330006382 dimerization interface [polypeptide binding]; other site 1283330006383 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1283330006384 Active Sites [active] 1283330006385 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1283330006386 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1283330006387 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1283330006388 alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291 1283330006389 Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400 1283330006390 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 1283330006391 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1283330006392 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1283330006393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283330006394 DNA-binding site [nucleotide binding]; DNA binding site 1283330006395 FCD domain; Region: FCD; pfam07729 1283330006396 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1283330006397 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1283330006398 tetramer interface [polypeptide binding]; other site 1283330006399 active site 1283330006400 Mg2+/Mn2+ binding site [ion binding]; other site 1283330006401 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1283330006402 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1283330006403 dimer interface [polypeptide binding]; other site 1283330006404 active site 1283330006405 citrylCoA binding site [chemical binding]; other site 1283330006406 oxalacetate/citrate binding site [chemical binding]; other site 1283330006407 coenzyme A binding site [chemical binding]; other site 1283330006408 catalytic triad [active] 1283330006409 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 1283330006410 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1283330006411 substrate binding site [chemical binding]; other site 1283330006412 ligand binding site [chemical binding]; other site 1283330006413 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1283330006414 substrate binding site [chemical binding]; other site 1283330006415 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 1283330006416 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1283330006417 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1283330006418 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1283330006419 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1283330006420 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1283330006421 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1283330006422 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1283330006423 RNA polymerase sigma factor SigX; Reviewed; Region: PRK09640 1283330006424 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330006425 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330006426 DNA binding residues [nucleotide binding] 1283330006427 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1283330006428 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1283330006429 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283330006430 ligand binding site [chemical binding]; other site 1283330006431 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1283330006432 active site 1283330006433 SAM binding site [chemical binding]; other site 1283330006434 homodimer interface [polypeptide binding]; other site 1283330006435 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1283330006436 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1283330006437 [4Fe-4S] binding site [ion binding]; other site 1283330006438 molybdopterin cofactor binding site; other site 1283330006439 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1283330006440 molybdopterin cofactor binding site; other site 1283330006441 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1283330006442 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1283330006443 [2Fe-2S] cluster binding site [ion binding]; other site 1283330006444 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1283330006445 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283330006446 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1283330006447 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1283330006448 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1283330006449 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1283330006450 active site 1283330006451 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1283330006452 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1283330006453 active site 1283330006454 ATP binding site [chemical binding]; other site 1283330006455 substrate binding site [chemical binding]; other site 1283330006456 activation loop (A-loop); other site 1283330006457 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1283330006458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330006459 putative substrate translocation pore; other site 1283330006460 Sulfatase; Region: Sulfatase; cl17466 1283330006461 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1283330006462 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1283330006463 putative substrate binding site [chemical binding]; other site 1283330006464 putative ATP binding site [chemical binding]; other site 1283330006465 Leucine rich repeat; Region: LRR_8; pfam13855 1283330006466 Leucine rich repeat; Region: LRR_8; pfam13855 1283330006467 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1283330006468 active site 1283330006469 ATP binding site [chemical binding]; other site 1283330006470 substrate binding site [chemical binding]; other site 1283330006471 activation loop (A-loop); other site 1283330006472 aminotransferase; Validated; Region: PRK08175 1283330006473 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283330006474 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330006475 homodimer interface [polypeptide binding]; other site 1283330006476 catalytic residue [active] 1283330006477 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1283330006478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330006479 active site 1283330006480 phosphorylation site [posttranslational modification] 1283330006481 intermolecular recognition site; other site 1283330006482 dimerization interface [polypeptide binding]; other site 1283330006483 ANTAR domain; Region: ANTAR; pfam03861 1283330006484 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1283330006485 NMT1-like family; Region: NMT1_2; pfam13379 1283330006486 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1283330006487 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1283330006488 substrate binding site [chemical binding]; other site 1283330006489 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1283330006490 substrate binding site [chemical binding]; other site 1283330006491 ligand binding site [chemical binding]; other site 1283330006492 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1283330006493 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1283330006494 dinuclear metal binding motif [ion binding]; other site 1283330006495 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1283330006496 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1283330006497 putative active site [active] 1283330006498 putative metal binding site [ion binding]; other site 1283330006499 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1283330006500 substrate binding site [chemical binding]; other site 1283330006501 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1283330006502 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1283330006503 active site 1283330006504 HIGH motif; other site 1283330006505 nucleotide binding site [chemical binding]; other site 1283330006506 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1283330006507 KMSKS motif; other site 1283330006508 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1283330006509 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1283330006510 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1283330006511 active site 1283330006512 HIGH motif; other site 1283330006513 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1283330006514 KMSKS motif; other site 1283330006515 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1283330006516 tRNA binding surface [nucleotide binding]; other site 1283330006517 anticodon binding site; other site 1283330006518 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1283330006519 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1283330006520 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1283330006521 homodimer interface [polypeptide binding]; other site 1283330006522 NADP binding site [chemical binding]; other site 1283330006523 substrate binding site [chemical binding]; other site 1283330006524 trigger factor; Provisional; Region: tig; PRK01490 1283330006525 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1283330006526 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1283330006527 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1283330006528 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1283330006529 oligomer interface [polypeptide binding]; other site 1283330006530 active site residues [active] 1283330006531 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1283330006532 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1283330006533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330006534 Walker A motif; other site 1283330006535 ATP binding site [chemical binding]; other site 1283330006536 Walker B motif; other site 1283330006537 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1283330006538 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1283330006539 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1283330006540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330006541 Walker A motif; other site 1283330006542 ATP binding site [chemical binding]; other site 1283330006543 Walker B motif; other site 1283330006544 arginine finger; other site 1283330006545 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1283330006546 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1283330006547 IHF dimer interface [polypeptide binding]; other site 1283330006548 IHF - DNA interface [nucleotide binding]; other site 1283330006549 periplasmic folding chaperone; Provisional; Region: PRK10788 1283330006550 SurA N-terminal domain; Region: SurA_N_3; pfam13624 1283330006551 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1283330006552 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1283330006553 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1283330006554 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 1283330006555 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283330006556 dimer interface [polypeptide binding]; other site 1283330006557 active site 1283330006558 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1283330006559 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1283330006560 NAD(P) binding site [chemical binding]; other site 1283330006561 homotetramer interface [polypeptide binding]; other site 1283330006562 homodimer interface [polypeptide binding]; other site 1283330006563 active site 1283330006564 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1283330006565 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1283330006566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330006567 phasin family protein; Region: phasin; TIGR01841 1283330006568 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 1283330006569 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 1283330006570 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1283330006571 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1283330006572 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1283330006573 homodecamer interface [polypeptide binding]; other site 1283330006574 GTP cyclohydrolase I; Provisional; Region: PLN03044 1283330006575 active site 1283330006576 putative catalytic site residues [active] 1283330006577 zinc binding site [ion binding]; other site 1283330006578 GTP-CH-I/GFRP interaction surface; other site 1283330006579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1283330006580 Smr domain; Region: Smr; pfam01713 1283330006581 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1283330006582 Isochorismatase family; Region: Isochorismatase; pfam00857 1283330006583 catalytic triad [active] 1283330006584 conserved cis-peptide bond; other site 1283330006585 HemK family putative methylases; Region: hemK_fam; TIGR00536 1283330006586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330006587 S-adenosylmethionine binding site [chemical binding]; other site 1283330006588 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1283330006589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330006590 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283330006591 putative substrate translocation pore; other site 1283330006592 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 1283330006593 intersubunit interface [polypeptide binding]; other site 1283330006594 active site 1283330006595 Zn2+ binding site [ion binding]; other site 1283330006596 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1283330006597 Cupin domain; Region: Cupin_2; cl17218 1283330006598 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 1283330006599 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1283330006600 motif II; other site 1283330006601 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1283330006602 spermidine synthase; Provisional; Region: PRK00811 1283330006603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330006604 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1283330006605 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1283330006606 Cytochrome c; Region: Cytochrom_C; pfam00034 1283330006607 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1283330006608 Predicted ATPase [General function prediction only]; Region: COG1485 1283330006609 Predicted permeases [General function prediction only]; Region: COG0679 1283330006610 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330006611 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330006612 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283330006613 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283330006614 Alginate lyase; Region: Alginate_lyase2; pfam08787 1283330006615 FlgN protein; Region: FlgN; pfam05130 1283330006616 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1283330006617 SAF-like; Region: SAF_2; pfam13144 1283330006618 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1283330006619 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1283330006620 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1283330006621 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1283330006622 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1283330006623 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1283330006624 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1283330006625 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1283330006626 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1283330006627 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1283330006628 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1283330006629 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1283330006630 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 1283330006631 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1283330006632 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1283330006633 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1283330006634 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1283330006635 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1283330006636 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1283330006637 Flagellar L-ring protein; Region: FlgH; pfam02107 1283330006638 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1283330006639 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1283330006640 Rod binding protein; Region: Rod-binding; cl01626 1283330006641 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1283330006642 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1283330006643 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1283330006644 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1283330006645 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1283330006646 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 1283330006647 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1283330006648 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1283330006649 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1283330006650 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1283330006651 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1283330006652 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1283330006653 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1283330006654 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1283330006655 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1283330006656 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1283330006657 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1283330006658 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1283330006659 Flagellar FliJ protein; Region: FliJ; pfam02050 1283330006660 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1283330006661 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1283330006662 Walker A motif/ATP binding site; other site 1283330006663 Walker B motif; other site 1283330006664 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1283330006665 Flagellar assembly protein FliH; Region: FliH; pfam02108 1283330006666 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1283330006667 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1283330006668 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1283330006669 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1283330006670 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1283330006671 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1283330006672 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1283330006673 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1283330006674 flagellar protein FliS; Validated; Region: fliS; PRK05685 1283330006675 Flagellar protein FliT; Region: FliT; pfam05400 1283330006676 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1283330006677 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1283330006678 Flagellar transcriptional activator (FlhD); Region: FlhD; pfam05247 1283330006679 transcriptional activator FlhC; Provisional; Region: PRK12722 1283330006680 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1283330006681 flagellar motor protein MotA; Validated; Region: PRK09110 1283330006682 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1283330006683 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1283330006684 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283330006685 ligand binding site [chemical binding]; other site 1283330006686 chemotaxis protein CheA; Provisional; Region: PRK10547 1283330006687 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1283330006688 putative binding surface; other site 1283330006689 active site 1283330006690 CheY binding; Region: CheY-binding; pfam09078 1283330006691 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1283330006692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330006693 ATP binding site [chemical binding]; other site 1283330006694 Mg2+ binding site [ion binding]; other site 1283330006695 G-X-G motif; other site 1283330006696 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1283330006697 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1283330006698 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1283330006699 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283330006700 dimer interface [polypeptide binding]; other site 1283330006701 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1283330006702 putative CheW interface [polypeptide binding]; other site 1283330006703 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283330006704 dimerization interface [polypeptide binding]; other site 1283330006705 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1283330006706 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283330006707 dimer interface [polypeptide binding]; other site 1283330006708 putative CheW interface [polypeptide binding]; other site 1283330006709 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330006710 PAS fold; Region: PAS_3; pfam08447 1283330006711 putative active site [active] 1283330006712 heme pocket [chemical binding]; other site 1283330006713 HAMP domain; Region: HAMP; pfam00672 1283330006714 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1283330006715 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283330006716 dimer interface [polypeptide binding]; other site 1283330006717 putative CheW interface [polypeptide binding]; other site 1283330006718 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1283330006719 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1283330006720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330006721 S-adenosylmethionine binding site [chemical binding]; other site 1283330006722 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1283330006723 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283330006724 Walker A/P-loop; other site 1283330006725 ATP binding site [chemical binding]; other site 1283330006726 Q-loop/lid; other site 1283330006727 ABC transporter signature motif; other site 1283330006728 Walker B; other site 1283330006729 D-loop; other site 1283330006730 H-loop/switch region; other site 1283330006731 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1283330006732 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283330006733 Walker A/P-loop; other site 1283330006734 ATP binding site [chemical binding]; other site 1283330006735 Q-loop/lid; other site 1283330006736 ABC transporter signature motif; other site 1283330006737 Walker B; other site 1283330006738 D-loop; other site 1283330006739 H-loop/switch region; other site 1283330006740 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1283330006741 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1283330006742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330006743 dimer interface [polypeptide binding]; other site 1283330006744 conserved gate region; other site 1283330006745 putative PBP binding loops; other site 1283330006746 ABC-ATPase subunit interface; other site 1283330006747 nickel transporter permease NikB; Provisional; Region: PRK10352 1283330006748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330006749 dimer interface [polypeptide binding]; other site 1283330006750 conserved gate region; other site 1283330006751 putative PBP binding loops; other site 1283330006752 ABC-ATPase subunit interface; other site 1283330006753 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1283330006754 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1283330006755 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 1283330006756 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1283330006757 DNA methylase; Region: N6_N4_Mtase; pfam01555 1283330006758 conjugal transfer protein TraL; Provisional; Region: PRK13886 1283330006759 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1283330006760 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1283330006761 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1283330006762 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1283330006763 Ligand Binding Site [chemical binding]; other site 1283330006764 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1283330006765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330006766 dimer interface [polypeptide binding]; other site 1283330006767 phosphorylation site [posttranslational modification] 1283330006768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330006769 ATP binding site [chemical binding]; other site 1283330006770 Mg2+ binding site [ion binding]; other site 1283330006771 G-X-G motif; other site 1283330006772 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1283330006773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330006774 active site 1283330006775 phosphorylation site [posttranslational modification] 1283330006776 intermolecular recognition site; other site 1283330006777 dimerization interface [polypeptide binding]; other site 1283330006778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283330006779 DNA binding site [nucleotide binding] 1283330006780 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1283330006781 potassium uptake protein; Region: kup; TIGR00794 1283330006782 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330006783 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330006784 Transposase domain (DUF772); Region: DUF772; pfam05598 1283330006785 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283330006786 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1283330006787 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 1283330006788 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283330006789 putative active site [active] 1283330006790 putative NTP binding site [chemical binding]; other site 1283330006791 putative nucleic acid binding site [nucleotide binding]; other site 1283330006792 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1283330006793 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1283330006794 NAD(P) binding site [chemical binding]; other site 1283330006795 substrate binding site [chemical binding]; other site 1283330006796 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1283330006797 active site 1283330006798 metal-binding site [ion binding] 1283330006799 nucleotide-binding site [chemical binding]; other site 1283330006800 Transposase domain (DUF772); Region: DUF772; pfam05598 1283330006801 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283330006802 DDE superfamily endonuclease; Region: DDE_4; cl17710 1283330006803 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1283330006804 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1283330006805 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1283330006806 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1283330006807 ligand-binding site [chemical binding]; other site 1283330006808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330006809 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283330006810 putative substrate translocation pore; other site 1283330006811 Transposase domain (DUF772); Region: DUF772; pfam05598 1283330006812 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283330006813 DDE superfamily endonuclease; Region: DDE_4; cl17710 1283330006814 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 1283330006815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330006816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330006817 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1283330006818 dimerization interface [polypeptide binding]; other site 1283330006819 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283330006820 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1283330006821 putative active site [active] 1283330006822 putative NTP binding site [chemical binding]; other site 1283330006823 putative nucleic acid binding site [nucleotide binding]; other site 1283330006824 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1283330006825 dimer interface [polypeptide binding]; other site 1283330006826 FMN binding site [chemical binding]; other site 1283330006827 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330006828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330006829 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283330006830 putative effector binding pocket; other site 1283330006831 dimerization interface [polypeptide binding]; other site 1283330006832 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1283330006833 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1283330006834 NADP binding site [chemical binding]; other site 1283330006835 dimer interface [polypeptide binding]; other site 1283330006836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1283330006837 Coenzyme A binding pocket [chemical binding]; other site 1283330006838 Predicted integral membrane protein [Function unknown]; Region: COG0392 1283330006839 cardiolipin synthase 2; Provisional; Region: PRK11263 1283330006840 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1283330006841 putative active site [active] 1283330006842 catalytic site [active] 1283330006843 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1283330006844 putative active site [active] 1283330006845 catalytic site [active] 1283330006846 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1283330006847 putative catalytic site [active] 1283330006848 putative metal binding site [ion binding]; other site 1283330006849 putative phosphate binding site [ion binding]; other site 1283330006850 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1283330006851 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1283330006852 NAD binding site [chemical binding]; other site 1283330006853 catalytic Zn binding site [ion binding]; other site 1283330006854 structural Zn binding site [ion binding]; other site 1283330006855 FOG: CBS domain [General function prediction only]; Region: COG0517 1283330006856 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1283330006857 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1283330006858 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1283330006859 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1283330006860 active site 1283330006861 catalytic site [active] 1283330006862 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1283330006863 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1283330006864 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1283330006865 active site 1283330006866 catalytic site [active] 1283330006867 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1283330006868 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1283330006869 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1283330006870 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1283330006871 catalytic site [active] 1283330006872 active site 1283330006873 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1283330006874 glycogen synthase; Provisional; Region: glgA; PRK00654 1283330006875 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1283330006876 ADP-binding pocket [chemical binding]; other site 1283330006877 homodimer interface [polypeptide binding]; other site 1283330006878 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1283330006879 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1283330006880 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1283330006881 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1283330006882 FAD binding site [chemical binding]; other site 1283330006883 substrate binding pocket [chemical binding]; other site 1283330006884 catalytic base [active] 1283330006885 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1283330006886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330006887 putative substrate translocation pore; other site 1283330006888 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1283330006889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330006890 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 1283330006891 dimerization interface [polypeptide binding]; other site 1283330006892 substrate binding pocket [chemical binding]; other site 1283330006893 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1283330006894 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1283330006895 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1283330006896 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1283330006897 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1283330006898 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1283330006899 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1283330006900 active site 1283330006901 tetramer interface; other site 1283330006902 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1283330006903 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1283330006904 active site 1283330006905 metal binding site [ion binding]; metal-binding site 1283330006906 glutathione reductase; Validated; Region: PRK06116 1283330006907 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283330006908 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283330006909 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1283330006910 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1283330006911 response regulator; Provisional; Region: PRK09483 1283330006912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330006913 active site 1283330006914 phosphorylation site [posttranslational modification] 1283330006915 intermolecular recognition site; other site 1283330006916 dimerization interface [polypeptide binding]; other site 1283330006917 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1283330006918 DNA binding residues [nucleotide binding] 1283330006919 dimerization interface [polypeptide binding]; other site 1283330006920 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1283330006921 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1283330006922 GIY-YIG motif/motif A; other site 1283330006923 active site 1283330006924 catalytic site [active] 1283330006925 putative DNA binding site [nucleotide binding]; other site 1283330006926 metal binding site [ion binding]; metal-binding site 1283330006927 UvrB/uvrC motif; Region: UVR; pfam02151 1283330006928 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1283330006929 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1283330006930 DNA binding site [nucleotide binding] 1283330006931 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1283330006932 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283330006933 active site 1283330006934 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1283330006935 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283330006936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283330006937 H+ Antiporter protein; Region: 2A0121; TIGR00900 1283330006938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330006939 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1283330006940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330006941 NAD(P) binding site [chemical binding]; other site 1283330006942 active site 1283330006943 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1283330006944 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1283330006945 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330006946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330006947 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1283330006948 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 1283330006949 PIN domain; Region: PIN_3; cl17397 1283330006950 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1283330006951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330006952 active site 1283330006953 phosphorylation site [posttranslational modification] 1283330006954 intermolecular recognition site; other site 1283330006955 dimerization interface [polypeptide binding]; other site 1283330006956 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1283330006957 Zn2+ binding site [ion binding]; other site 1283330006958 Mg2+ binding site [ion binding]; other site 1283330006959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330006960 dimer interface [polypeptide binding]; other site 1283330006961 phosphorylation site [posttranslational modification] 1283330006962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330006963 ATP binding site [chemical binding]; other site 1283330006964 Mg2+ binding site [ion binding]; other site 1283330006965 G-X-G motif; other site 1283330006966 Response regulator receiver domain; Region: Response_reg; pfam00072 1283330006967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330006968 active site 1283330006969 phosphorylation site [posttranslational modification] 1283330006970 intermolecular recognition site; other site 1283330006971 dimerization interface [polypeptide binding]; other site 1283330006972 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1283330006973 putative binding surface; other site 1283330006974 active site 1283330006975 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1283330006976 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1283330006977 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 1283330006978 PAS domain; Region: PAS; smart00091 1283330006979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330006980 putative active site [active] 1283330006981 heme pocket [chemical binding]; other site 1283330006982 GAF domain; Region: GAF; cl17456 1283330006983 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330006984 metal binding site [ion binding]; metal-binding site 1283330006985 active site 1283330006986 I-site; other site 1283330006987 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283330006988 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330006989 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330006990 metal binding site [ion binding]; metal-binding site 1283330006991 active site 1283330006992 I-site; other site 1283330006993 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1283330006994 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1283330006995 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283330006996 active site 1283330006997 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1283330006998 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1283330006999 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283330007000 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283330007001 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1283330007002 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1283330007003 Na binding site [ion binding]; other site 1283330007004 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1283330007005 acyl-CoA synthetase; Validated; Region: PRK08162 1283330007006 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1283330007007 acyl-activating enzyme (AAE) consensus motif; other site 1283330007008 putative active site [active] 1283330007009 AMP binding site [chemical binding]; other site 1283330007010 putative CoA binding site [chemical binding]; other site 1283330007011 PAS domain S-box; Region: sensory_box; TIGR00229 1283330007012 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330007013 putative active site [active] 1283330007014 heme pocket [chemical binding]; other site 1283330007015 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1283330007016 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330007017 putative active site [active] 1283330007018 heme pocket [chemical binding]; other site 1283330007019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330007020 dimer interface [polypeptide binding]; other site 1283330007021 phosphorylation site [posttranslational modification] 1283330007022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330007023 ATP binding site [chemical binding]; other site 1283330007024 G-X-G motif; other site 1283330007025 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1283330007026 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330007027 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330007028 DNA binding residues [nucleotide binding] 1283330007029 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 1283330007030 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1283330007031 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1283330007032 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1283330007033 Water Stress and Hypersensitive response; Region: WHy; smart00769 1283330007034 Penicillin amidase; Region: Penicil_amidase; pfam01804 1283330007035 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1283330007036 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 1283330007037 active site 1283330007038 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1283330007039 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1283330007040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330007041 active site 1283330007042 phosphorylation site [posttranslational modification] 1283330007043 intermolecular recognition site; other site 1283330007044 dimerization interface [polypeptide binding]; other site 1283330007045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1283330007046 DNA binding residues [nucleotide binding] 1283330007047 dimerization interface [polypeptide binding]; other site 1283330007048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283330007049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283330007050 patatin-related protein; Region: TIGR03607 1283330007051 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1283330007052 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330007053 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1283330007054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330007055 DNA binding residues [nucleotide binding] 1283330007056 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283330007057 FecR protein; Region: FecR; pfam04773 1283330007058 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1283330007059 Cupin-like domain; Region: Cupin_8; pfam13621 1283330007060 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1283330007061 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1283330007062 active site 1283330007063 dimer interface [polypeptide binding]; other site 1283330007064 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1283330007065 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1283330007066 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1283330007067 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1283330007068 Transposase; Region: HTH_Tnp_1; cl17663 1283330007069 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330007070 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330007071 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283330007072 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1283330007073 Integrase core domain; Region: rve; pfam00665 1283330007074 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283330007075 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283330007076 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330007077 N-terminal plug; other site 1283330007078 ligand-binding site [chemical binding]; other site 1283330007079 Condensation domain; Region: Condensation; pfam00668 1283330007080 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1283330007081 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283330007082 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283330007083 acyl-activating enzyme (AAE) consensus motif; other site 1283330007084 AMP binding site [chemical binding]; other site 1283330007085 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330007086 Condensation domain; Region: Condensation; pfam00668 1283330007087 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1283330007088 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1283330007089 Condensation domain; Region: Condensation; pfam00668 1283330007090 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1283330007091 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283330007092 acyl-activating enzyme (AAE) consensus motif; other site 1283330007093 AMP binding site [chemical binding]; other site 1283330007094 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330007095 peptide synthase; Provisional; Region: PRK12316 1283330007096 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283330007097 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283330007098 acyl-activating enzyme (AAE) consensus motif; other site 1283330007099 AMP binding site [chemical binding]; other site 1283330007100 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330007101 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1283330007102 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283330007103 acyl-activating enzyme (AAE) consensus motif; other site 1283330007104 AMP binding site [chemical binding]; other site 1283330007105 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330007106 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283330007107 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283330007108 acyl-activating enzyme (AAE) consensus motif; other site 1283330007109 AMP binding site [chemical binding]; other site 1283330007110 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330007111 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1283330007112 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283330007113 acyl-activating enzyme (AAE) consensus motif; other site 1283330007114 AMP binding site [chemical binding]; other site 1283330007115 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330007116 peptide synthase; Provisional; Region: PRK12467 1283330007117 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283330007118 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283330007119 acyl-activating enzyme (AAE) consensus motif; other site 1283330007120 AMP binding site [chemical binding]; other site 1283330007121 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330007122 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283330007123 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283330007124 acyl-activating enzyme (AAE) consensus motif; other site 1283330007125 AMP binding site [chemical binding]; other site 1283330007126 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330007127 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1283330007128 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283330007129 acyl-activating enzyme (AAE) consensus motif; other site 1283330007130 AMP binding site [chemical binding]; other site 1283330007131 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330007132 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1283330007133 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283330007134 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283330007135 acyl-activating enzyme (AAE) consensus motif; other site 1283330007136 AMP binding site [chemical binding]; other site 1283330007137 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330007138 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1283330007139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283330007140 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1283330007141 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1283330007142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1283330007143 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 1283330007144 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1283330007145 inhibitor-cofactor binding pocket; inhibition site 1283330007146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330007147 catalytic residue [active] 1283330007148 peptide synthase; Validated; Region: PRK05691 1283330007149 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1283330007150 acyl-activating enzyme (AAE) consensus motif; other site 1283330007151 active site 1283330007152 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330007153 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283330007154 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283330007155 acyl-activating enzyme (AAE) consensus motif; other site 1283330007156 AMP binding site [chemical binding]; other site 1283330007157 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330007158 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283330007159 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283330007160 acyl-activating enzyme (AAE) consensus motif; other site 1283330007161 AMP binding site [chemical binding]; other site 1283330007162 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330007163 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1283330007164 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1283330007165 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1283330007166 acyl-activating enzyme (AAE) consensus motif; other site 1283330007167 AMP binding site [chemical binding]; other site 1283330007168 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330007169 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 1283330007170 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330007171 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330007172 DNA binding residues [nucleotide binding] 1283330007173 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1283330007174 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1283330007175 active site 1283330007176 FMN binding site [chemical binding]; other site 1283330007177 substrate binding site [chemical binding]; other site 1283330007178 3Fe-4S cluster binding site [ion binding]; other site 1283330007179 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1283330007180 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 1283330007181 Int/Topo IB signature motif; other site 1283330007182 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 1283330007183 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1283330007184 DNA binding site [nucleotide binding] 1283330007185 dimer interface [polypeptide binding]; other site 1283330007186 active site 1283330007187 Int/Topo IB signature motif; other site 1283330007188 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1283330007189 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283330007190 active site 1283330007191 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 1283330007192 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 1283330007193 FAD binding pocket [chemical binding]; other site 1283330007194 FAD binding motif [chemical binding]; other site 1283330007195 phosphate binding motif [ion binding]; other site 1283330007196 beta-alpha-beta structure motif; other site 1283330007197 NAD binding pocket [chemical binding]; other site 1283330007198 Iron coordination center [ion binding]; other site 1283330007199 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1283330007200 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1283330007201 putative dimer interface [polypeptide binding]; other site 1283330007202 chaperonin GroEL; Reviewed; Region: groEL; PRK12851 1283330007203 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1283330007204 ring oligomerisation interface [polypeptide binding]; other site 1283330007205 ATP/Mg binding site [chemical binding]; other site 1283330007206 stacking interactions; other site 1283330007207 hinge regions; other site 1283330007208 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283330007209 Ligand Binding Site [chemical binding]; other site 1283330007210 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283330007211 Ligand Binding Site [chemical binding]; other site 1283330007212 Staphylococcal nuclease homologue; Region: SNase; pfam00565 1283330007213 Catalytic site; other site 1283330007214 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1283330007215 Ligand binding site; other site 1283330007216 metal-binding site 1283330007217 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1283330007218 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1283330007219 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1283330007220 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1283330007221 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1283330007222 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283330007223 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283330007224 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1283330007225 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283330007226 catalytic loop [active] 1283330007227 iron binding site [ion binding]; other site 1283330007228 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1283330007229 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283330007230 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283330007231 active site 1283330007232 catalytic tetrad [active] 1283330007233 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330007234 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330007235 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1283330007236 putative effector binding pocket; other site 1283330007237 putative dimerization interface [polypeptide binding]; other site 1283330007238 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1283330007239 Sulfatase; Region: Sulfatase; pfam00884 1283330007240 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 1283330007241 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1283330007242 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1283330007243 hypothetical protein; Provisional; Region: PRK02237 1283330007244 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1283330007245 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1283330007246 active site 1283330007247 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283330007248 dimerization interface [polypeptide binding]; other site 1283330007249 putative DNA binding site [nucleotide binding]; other site 1283330007250 putative Zn2+ binding site [ion binding]; other site 1283330007251 Sodium Bile acid symporter family; Region: SBF; cl17470 1283330007252 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 1283330007253 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1283330007254 putative aromatic amino acid binding site; other site 1283330007255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330007256 Walker A motif; other site 1283330007257 ATP binding site [chemical binding]; other site 1283330007258 Walker B motif; other site 1283330007259 arginine finger; other site 1283330007260 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330007261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330007262 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1283330007263 putative substrate translocation pore; other site 1283330007264 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1283330007265 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1283330007266 active site 1283330007267 catalytic residues [active] 1283330007268 metal binding site [ion binding]; metal-binding site 1283330007269 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1283330007270 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1283330007271 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330007272 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330007273 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1283330007274 putative dimerization interface [polypeptide binding]; other site 1283330007275 glycine dehydrogenase; Provisional; Region: PRK05367 1283330007276 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1283330007277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330007278 tetramer interface [polypeptide binding]; other site 1283330007279 catalytic residue [active] 1283330007280 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1283330007281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330007282 tetramer interface [polypeptide binding]; other site 1283330007283 catalytic residue [active] 1283330007284 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1283330007285 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1283330007286 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1283330007287 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1283330007288 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1283330007289 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1283330007290 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283330007291 catalytic loop [active] 1283330007292 iron binding site [ion binding]; other site 1283330007293 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1283330007294 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1283330007295 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283330007296 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1283330007297 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283330007298 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283330007299 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1283330007300 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1283330007301 Walker A/P-loop; other site 1283330007302 ATP binding site [chemical binding]; other site 1283330007303 Q-loop/lid; other site 1283330007304 ABC transporter signature motif; other site 1283330007305 Walker B; other site 1283330007306 D-loop; other site 1283330007307 H-loop/switch region; other site 1283330007308 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1283330007309 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1283330007310 Walker A/P-loop; other site 1283330007311 ATP binding site [chemical binding]; other site 1283330007312 Q-loop/lid; other site 1283330007313 ABC transporter signature motif; other site 1283330007314 Walker B; other site 1283330007315 D-loop; other site 1283330007316 H-loop/switch region; other site 1283330007317 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1283330007318 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1283330007319 TM-ABC transporter signature motif; other site 1283330007320 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1283330007321 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1283330007322 TM-ABC transporter signature motif; other site 1283330007323 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1283330007324 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1283330007325 dimerization interface [polypeptide binding]; other site 1283330007326 ligand binding site [chemical binding]; other site 1283330007327 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1283330007328 imidazolonepropionase; Validated; Region: PRK09356 1283330007329 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1283330007330 active site 1283330007331 urocanate hydratase; Provisional; Region: PRK05414 1283330007332 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1283330007333 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283330007334 DNA binding site [nucleotide binding] 1283330007335 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1283330007336 putative ligand binding site [chemical binding]; other site 1283330007337 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1283330007338 short chain dehydrogenase; Provisional; Region: PRK06198 1283330007339 classical (c) SDRs; Region: SDR_c; cd05233 1283330007340 NAD(P) binding site [chemical binding]; other site 1283330007341 active site 1283330007342 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1283330007343 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1283330007344 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283330007345 putative ligand binding site [chemical binding]; other site 1283330007346 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1283330007347 RES domain; Region: RES; pfam08808 1283330007348 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1283330007349 active sites [active] 1283330007350 tetramer interface [polypeptide binding]; other site 1283330007351 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1283330007352 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1283330007353 active site 1283330007354 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1283330007355 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1283330007356 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1283330007357 catalytic residue [active] 1283330007358 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1283330007359 catalytic residues [active] 1283330007360 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283330007361 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283330007362 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330007363 PAS domain; Region: PAS_9; pfam13426 1283330007364 putative active site [active] 1283330007365 PAS domain S-box; Region: sensory_box; TIGR00229 1283330007366 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330007367 putative active site [active] 1283330007368 heme pocket [chemical binding]; other site 1283330007369 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330007370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330007371 metal binding site [ion binding]; metal-binding site 1283330007372 active site 1283330007373 I-site; other site 1283330007374 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283330007375 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283330007376 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283330007377 active site 1283330007378 catalytic tetrad [active] 1283330007379 TLC ATP/ADP transporter; Region: TLC; cl03940 1283330007380 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1283330007381 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330007382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330007383 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283330007384 putative effector binding pocket; other site 1283330007385 dimerization interface [polypeptide binding]; other site 1283330007386 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283330007387 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330007388 N-terminal plug; other site 1283330007389 ligand-binding site [chemical binding]; other site 1283330007390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1283330007391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330007392 S-adenosylmethionine binding site [chemical binding]; other site 1283330007393 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1283330007394 putative ligand binding residues [chemical binding]; other site 1283330007395 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1283330007396 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1283330007397 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1283330007398 dimer interface [polypeptide binding]; other site 1283330007399 putative PBP binding regions; other site 1283330007400 ABC-ATPase subunit interface; other site 1283330007401 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1283330007402 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1283330007403 Walker A/P-loop; other site 1283330007404 ATP binding site [chemical binding]; other site 1283330007405 Q-loop/lid; other site 1283330007406 ABC transporter signature motif; other site 1283330007407 Walker B; other site 1283330007408 D-loop; other site 1283330007409 H-loop/switch region; other site 1283330007410 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1283330007411 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1283330007412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330007413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330007414 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283330007415 dimerization interface [polypeptide binding]; other site 1283330007416 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1283330007417 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1283330007418 Nif-specific regulatory protein; Region: nifA; TIGR01817 1283330007419 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1283330007420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330007421 Walker A motif; other site 1283330007422 ATP binding site [chemical binding]; other site 1283330007423 Walker B motif; other site 1283330007424 arginine finger; other site 1283330007425 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330007426 Lysine efflux permease [General function prediction only]; Region: COG1279 1283330007427 Uncharacterized conserved protein [Function unknown]; Region: COG3603 1283330007428 Family description; Region: ACT_7; pfam13840 1283330007429 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1283330007430 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1283330007431 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283330007432 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1283330007433 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 1283330007434 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1283330007435 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1283330007436 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1283330007437 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1283330007438 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1283330007439 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1283330007440 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1283330007441 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1283330007442 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1283330007443 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1283330007444 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1283330007445 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1283330007446 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1283330007447 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1283330007448 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1283330007449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330007450 Walker A motif; other site 1283330007451 ATP binding site [chemical binding]; other site 1283330007452 Walker B motif; other site 1283330007453 arginine finger; other site 1283330007454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330007455 Walker A motif; other site 1283330007456 ATP binding site [chemical binding]; other site 1283330007457 Walker B motif; other site 1283330007458 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1283330007459 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1283330007460 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1283330007461 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1283330007462 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1283330007463 Protein of unknown function (DUF796); Region: DUF796; pfam05638 1283330007464 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1283330007465 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1283330007466 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1283330007467 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1283330007468 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1283330007469 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1283330007470 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1283330007471 active site 1283330007472 ATP binding site [chemical binding]; other site 1283330007473 substrate binding site [chemical binding]; other site 1283330007474 activation loop (A-loop); other site 1283330007475 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 1283330007476 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1283330007477 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1283330007478 G1 box; other site 1283330007479 GTP/Mg2+ binding site [chemical binding]; other site 1283330007480 G2 box; other site 1283330007481 G3 box; other site 1283330007482 Switch II region; other site 1283330007483 G4 box; other site 1283330007484 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1283330007485 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1283330007486 hypothetical protein; Provisional; Region: PRK07033 1283330007487 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 1283330007488 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283330007489 ligand binding site [chemical binding]; other site 1283330007490 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1283330007491 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1283330007492 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1283330007493 FHA domain; Region: FHA; pfam00498 1283330007494 phosphopeptide binding site; other site 1283330007495 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 1283330007496 active site 1283330007497 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 1283330007498 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283330007499 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1283330007500 Walker A/P-loop; other site 1283330007501 ATP binding site [chemical binding]; other site 1283330007502 Q-loop/lid; other site 1283330007503 ABC transporter signature motif; other site 1283330007504 Walker B; other site 1283330007505 D-loop; other site 1283330007506 H-loop/switch region; other site 1283330007507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330007508 metabolite-proton symporter; Region: 2A0106; TIGR00883 1283330007509 putative substrate translocation pore; other site 1283330007510 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1283330007511 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1283330007512 Transposase domain (DUF772); Region: DUF772; pfam05598 1283330007513 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283330007514 DDE superfamily endonuclease; Region: DDE_4; cl17710 1283330007515 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1283330007516 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1283330007517 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283330007518 DNA-binding site [nucleotide binding]; DNA binding site 1283330007519 FCD domain; Region: FCD; pfam07729 1283330007520 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1283330007521 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283330007522 DNA binding site [nucleotide binding] 1283330007523 domain linker motif; other site 1283330007524 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1283330007525 putative dimerization interface [polypeptide binding]; other site 1283330007526 putative ligand binding site [chemical binding]; other site 1283330007527 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1283330007528 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1283330007529 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1283330007530 substrate binding site [chemical binding]; other site 1283330007531 ATP binding site [chemical binding]; other site 1283330007532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330007533 D-galactonate transporter; Region: 2A0114; TIGR00893 1283330007534 putative substrate translocation pore; other site 1283330007535 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1283330007536 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1283330007537 dimerization interface [polypeptide binding]; other site 1283330007538 ligand binding site [chemical binding]; other site 1283330007539 NADP binding site [chemical binding]; other site 1283330007540 catalytic site [active] 1283330007541 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330007542 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283330007543 trimer interface; other site 1283330007544 sugar binding site [chemical binding]; other site 1283330007545 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1283330007546 Na binding site [ion binding]; other site 1283330007547 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 1283330007548 Domain interface; other site 1283330007549 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 1283330007550 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1283330007551 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 1283330007552 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1283330007553 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 1283330007554 active site 1283330007555 putative lithium-binding site [ion binding]; other site 1283330007556 substrate binding site [chemical binding]; other site 1283330007557 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1283330007558 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1283330007559 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1283330007560 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1283330007561 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1283330007562 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1283330007563 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 1283330007564 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1283330007565 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1283330007566 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1283330007567 putative arabinose transporter; Provisional; Region: PRK03545 1283330007568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330007569 putative substrate translocation pore; other site 1283330007570 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1283330007571 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1283330007572 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1283330007573 Class II fumarases; Region: Fumarase_classII; cd01362 1283330007574 active site 1283330007575 tetramer interface [polypeptide binding]; other site 1283330007576 DNA topoisomerase III; Provisional; Region: PRK07726 1283330007577 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1283330007578 active site 1283330007579 putative interdomain interaction site [polypeptide binding]; other site 1283330007580 putative metal-binding site [ion binding]; other site 1283330007581 putative nucleotide binding site [chemical binding]; other site 1283330007582 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1283330007583 domain I; other site 1283330007584 DNA binding groove [nucleotide binding] 1283330007585 phosphate binding site [ion binding]; other site 1283330007586 domain II; other site 1283330007587 domain III; other site 1283330007588 nucleotide binding site [chemical binding]; other site 1283330007589 catalytic site [active] 1283330007590 domain IV; other site 1283330007591 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283330007592 trimer interface; other site 1283330007593 sugar binding site [chemical binding]; other site 1283330007594 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1283330007595 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1283330007596 tetrameric interface [polypeptide binding]; other site 1283330007597 activator binding site; other site 1283330007598 NADP binding site [chemical binding]; other site 1283330007599 substrate binding site [chemical binding]; other site 1283330007600 catalytic residues [active] 1283330007601 enolase; Provisional; Region: eno; PRK00077 1283330007602 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1283330007603 dimer interface [polypeptide binding]; other site 1283330007604 metal binding site [ion binding]; metal-binding site 1283330007605 substrate binding pocket [chemical binding]; other site 1283330007606 pyruvate kinase; Provisional; Region: PRK05826 1283330007607 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1283330007608 domain interfaces; other site 1283330007609 active site 1283330007610 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1283330007611 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1283330007612 active site 1283330007613 intersubunit interface [polypeptide binding]; other site 1283330007614 catalytic residue [active] 1283330007615 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1283330007616 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1283330007617 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1283330007618 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1283330007619 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1283330007620 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1283330007621 putative active site [active] 1283330007622 phosphogluconate dehydratase; Validated; Region: PRK09054 1283330007623 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1283330007624 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1283330007625 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283330007626 DNA binding site [nucleotide binding] 1283330007627 domain linker motif; other site 1283330007628 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1283330007629 putative dimerization interface [polypeptide binding]; other site 1283330007630 putative ligand binding site [chemical binding]; other site 1283330007631 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1283330007632 AAA domain; Region: AAA_33; pfam13671 1283330007633 ATP-binding site [chemical binding]; other site 1283330007634 Gluconate-6-phosphate binding site [chemical binding]; other site 1283330007635 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 1283330007636 N- and C-terminal domain interface [polypeptide binding]; other site 1283330007637 D-xylulose kinase; Region: XylB; TIGR01312 1283330007638 active site 1283330007639 MgATP binding site [chemical binding]; other site 1283330007640 catalytic site [active] 1283330007641 metal binding site [ion binding]; metal-binding site 1283330007642 xylulose binding site [chemical binding]; other site 1283330007643 putative homodimer interface [polypeptide binding]; other site 1283330007644 transketolase; Reviewed; Region: PRK12753 1283330007645 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1283330007646 TPP-binding site [chemical binding]; other site 1283330007647 dimer interface [polypeptide binding]; other site 1283330007648 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1283330007649 PYR/PP interface [polypeptide binding]; other site 1283330007650 dimer interface [polypeptide binding]; other site 1283330007651 TPP binding site [chemical binding]; other site 1283330007652 transaldolase-like protein; Provisional; Region: PTZ00411 1283330007653 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1283330007654 active site 1283330007655 dimer interface [polypeptide binding]; other site 1283330007656 catalytic residue [active] 1283330007657 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1283330007658 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1283330007659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330007660 motif I; other site 1283330007661 motif II; other site 1283330007662 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1283330007663 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1283330007664 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1283330007665 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1283330007666 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1283330007667 Walker A/P-loop; other site 1283330007668 ATP binding site [chemical binding]; other site 1283330007669 Q-loop/lid; other site 1283330007670 ABC transporter signature motif; other site 1283330007671 Walker B; other site 1283330007672 D-loop; other site 1283330007673 H-loop/switch region; other site 1283330007674 TOBE domain; Region: TOBE_2; pfam08402 1283330007675 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1283330007676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330007677 dimer interface [polypeptide binding]; other site 1283330007678 conserved gate region; other site 1283330007679 ABC-ATPase subunit interface; other site 1283330007680 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1283330007681 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1283330007682 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1283330007683 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1283330007684 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1283330007685 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330007686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330007687 phosphoglyceromutase; Provisional; Region: PRK05434 1283330007688 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1283330007689 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1283330007690 Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919 1283330007691 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1283330007692 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1283330007693 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 1283330007694 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1283330007695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1283330007696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330007697 S-adenosylmethionine binding site [chemical binding]; other site 1283330007698 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 1283330007699 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1283330007700 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1283330007701 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1283330007702 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1283330007703 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283330007704 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1283330007705 putative active site [active] 1283330007706 putative NTP binding site [chemical binding]; other site 1283330007707 putative nucleic acid binding site [nucleotide binding]; other site 1283330007708 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1283330007709 putative inner membrane peptidase; Provisional; Region: PRK11778 1283330007710 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1283330007711 tandem repeat interface [polypeptide binding]; other site 1283330007712 oligomer interface [polypeptide binding]; other site 1283330007713 active site residues [active] 1283330007714 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1283330007715 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1283330007716 catalytic core [active] 1283330007717 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1283330007718 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1283330007719 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1283330007720 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1283330007721 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1283330007722 putative NADH binding site [chemical binding]; other site 1283330007723 putative active site [active] 1283330007724 nudix motif; other site 1283330007725 putative metal binding site [ion binding]; other site 1283330007726 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283330007727 ligand binding site [chemical binding]; other site 1283330007728 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1283330007729 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1283330007730 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 1283330007731 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 1283330007732 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1283330007733 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1283330007734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330007735 non-specific DNA binding site [nucleotide binding]; other site 1283330007736 salt bridge; other site 1283330007737 sequence-specific DNA binding site [nucleotide binding]; other site 1283330007738 flagellin; Validated; Region: PRK08026 1283330007739 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1283330007740 Flagellin protein; Region: FliC; pfam12445 1283330007741 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1283330007742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283330007743 TPR motif; other site 1283330007744 TPR repeat; Region: TPR_11; pfam13414 1283330007745 binding surface 1283330007746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283330007747 binding surface 1283330007748 TPR motif; other site 1283330007749 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1283330007750 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1283330007751 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1283330007752 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1283330007753 active site 1283330007754 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1283330007755 Cephalosporin hydroxylase; Region: CmcI; pfam04989 1283330007756 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1283330007757 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1283330007758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330007759 S-adenosylmethionine binding site [chemical binding]; other site 1283330007760 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1283330007761 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1283330007762 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1283330007763 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1283330007764 NAD binding site [chemical binding]; other site 1283330007765 homotetramer interface [polypeptide binding]; other site 1283330007766 homodimer interface [polypeptide binding]; other site 1283330007767 substrate binding site [chemical binding]; other site 1283330007768 active site 1283330007769 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1283330007770 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1283330007771 substrate binding site; other site 1283330007772 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1283330007773 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283330007774 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1283330007775 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1283330007776 Helix-turn-helix domain; Region: HTH_37; pfam13744 1283330007777 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1283330007778 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1283330007779 HicB family; Region: HicB; pfam05534 1283330007780 FlaG protein; Region: FlaG; pfam03646 1283330007781 PilZ domain; Region: PilZ; pfam07238 1283330007782 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1283330007783 Zn2+ binding site [ion binding]; other site 1283330007784 Mg2+ binding site [ion binding]; other site 1283330007785 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1283330007786 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330007787 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1283330007788 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330007789 DNA binding residues [nucleotide binding] 1283330007790 Flagellar protein FlhE; Region: FlhE; pfam06366 1283330007791 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 1283330007792 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283330007793 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1283330007794 FHIPEP family; Region: FHIPEP; pfam00771 1283330007795 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1283330007796 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1283330007797 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1283330007798 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1283330007799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330007800 active site 1283330007801 phosphorylation site [posttranslational modification] 1283330007802 intermolecular recognition site; other site 1283330007803 dimerization interface [polypeptide binding]; other site 1283330007804 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283330007805 dimerization interface [polypeptide binding]; other site 1283330007806 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1283330007807 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283330007808 dimer interface [polypeptide binding]; other site 1283330007809 putative CheW interface [polypeptide binding]; other site 1283330007810 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283330007811 dimerization interface [polypeptide binding]; other site 1283330007812 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1283330007813 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283330007814 dimer interface [polypeptide binding]; other site 1283330007815 putative CheW interface [polypeptide binding]; other site 1283330007816 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1283330007817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330007818 active site 1283330007819 phosphorylation site [posttranslational modification] 1283330007820 intermolecular recognition site; other site 1283330007821 dimerization interface [polypeptide binding]; other site 1283330007822 CheB methylesterase; Region: CheB_methylest; pfam01339 1283330007823 glycogen branching enzyme; Provisional; Region: PRK05402 1283330007824 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 1283330007825 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1283330007826 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1283330007827 active site 1283330007828 catalytic site [active] 1283330007829 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1283330007830 trehalose synthase; Region: treS_nterm; TIGR02456 1283330007831 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1283330007832 active site 1283330007833 catalytic site [active] 1283330007834 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1283330007835 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1283330007836 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1283330007837 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1283330007838 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1283330007839 active site 1283330007840 homodimer interface [polypeptide binding]; other site 1283330007841 catalytic site [active] 1283330007842 acceptor binding site [chemical binding]; other site 1283330007843 YcaO domain protein; Region: TIGR03549 1283330007844 OsmC-like protein; Region: OsmC; pfam02566 1283330007845 YcaO-like family; Region: YcaO; pfam02624 1283330007846 Predicted flavoproteins [General function prediction only]; Region: COG2081 1283330007847 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1283330007848 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1283330007849 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283330007850 catalytic residue [active] 1283330007851 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1283330007852 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283330007853 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330007854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330007855 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1283330007856 YccA-like proteins; Region: YccA_like; cd10433 1283330007857 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1283330007858 sulfur relay protein TusC; Validated; Region: PRK00211 1283330007859 DsrH like protein; Region: DsrH; pfam04077 1283330007860 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1283330007861 DsrC like protein; Region: DsrC; cl01101 1283330007862 hypothetical protein; Validated; Region: PRK09071 1283330007863 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1283330007864 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1283330007865 siroheme synthase; Provisional; Region: cysG; PRK10637 1283330007866 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1283330007867 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1283330007868 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1283330007869 active site 1283330007870 SAM binding site [chemical binding]; other site 1283330007871 homodimer interface [polypeptide binding]; other site 1283330007872 seryl-tRNA synthetase; Provisional; Region: PRK05431 1283330007873 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1283330007874 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1283330007875 dimer interface [polypeptide binding]; other site 1283330007876 active site 1283330007877 motif 1; other site 1283330007878 motif 2; other site 1283330007879 motif 3; other site 1283330007880 camphor resistance protein CrcB; Provisional; Region: PRK14234 1283330007881 recombination factor protein RarA; Reviewed; Region: PRK13342 1283330007882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330007883 Walker A motif; other site 1283330007884 ATP binding site [chemical binding]; other site 1283330007885 Walker B motif; other site 1283330007886 arginine finger; other site 1283330007887 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1283330007888 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1283330007889 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1283330007890 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1283330007891 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1283330007892 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1283330007893 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1283330007894 thioredoxin reductase; Provisional; Region: PRK10262 1283330007895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283330007896 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283330007897 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1283330007898 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1283330007899 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1283330007900 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1283330007901 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1283330007902 rRNA binding site [nucleotide binding]; other site 1283330007903 predicted 30S ribosome binding site; other site 1283330007904 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1283330007905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330007906 Walker A motif; other site 1283330007907 ATP binding site [chemical binding]; other site 1283330007908 Walker B motif; other site 1283330007909 arginine finger; other site 1283330007910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330007911 Walker A motif; other site 1283330007912 ATP binding site [chemical binding]; other site 1283330007913 Walker B motif; other site 1283330007914 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1283330007915 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1283330007916 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1283330007917 DNA-binding site [nucleotide binding]; DNA binding site 1283330007918 RNA-binding motif; other site 1283330007919 isocitrate dehydrogenase, NADP-dependent, monomeric type; Region: monomer_idh; TIGR00178 1283330007920 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1283330007921 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1283330007922 nudix motif; other site 1283330007923 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1283330007924 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1283330007925 putative lysogenization regulator; Reviewed; Region: PRK00218 1283330007926 adenylosuccinate lyase; Provisional; Region: PRK09285 1283330007927 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1283330007928 tetramer interface [polypeptide binding]; other site 1283330007929 active site 1283330007930 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1283330007931 Cupin domain; Region: Cupin_2; cl17218 1283330007932 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1283330007933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1283330007934 Coenzyme A binding pocket [chemical binding]; other site 1283330007935 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1283330007936 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1283330007937 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1283330007938 tetramer interface [polypeptide binding]; other site 1283330007939 active site 1283330007940 Mg2+/Mn2+ binding site [ion binding]; other site 1283330007941 isocitrate lyase; Region: PLN02892 1283330007942 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1283330007943 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1283330007944 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1283330007945 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1283330007946 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1283330007947 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1283330007948 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1283330007949 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1283330007950 putative dimer interface [polypeptide binding]; other site 1283330007951 [2Fe-2S] cluster binding site [ion binding]; other site 1283330007952 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1283330007953 SLBB domain; Region: SLBB; pfam10531 1283330007954 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1283330007955 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1283330007956 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283330007957 catalytic loop [active] 1283330007958 iron binding site [ion binding]; other site 1283330007959 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1283330007960 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1283330007961 [4Fe-4S] binding site [ion binding]; other site 1283330007962 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1283330007963 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1283330007964 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1283330007965 4Fe-4S binding domain; Region: Fer4; pfam00037 1283330007966 4Fe-4S binding domain; Region: Fer4; pfam00037 1283330007967 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1283330007968 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1283330007969 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1283330007970 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1283330007971 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1283330007972 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1283330007973 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1283330007974 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1283330007975 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1283330007976 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1283330007977 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283330007978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330007979 ATP binding site [chemical binding]; other site 1283330007980 Mg2+ binding site [ion binding]; other site 1283330007981 G-X-G motif; other site 1283330007982 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1283330007983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330007984 active site 1283330007985 phosphorylation site [posttranslational modification] 1283330007986 intermolecular recognition site; other site 1283330007987 dimerization interface [polypeptide binding]; other site 1283330007988 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283330007989 DNA binding site [nucleotide binding] 1283330007990 Predicted membrane protein [Function unknown]; Region: COG3212 1283330007991 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1283330007992 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1283330007993 active site 1283330007994 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1283330007995 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1283330007996 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1283330007997 catalytic residue [active] 1283330007998 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1283330007999 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1283330008000 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1283330008001 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1283330008002 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1283330008003 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330008004 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330008005 metal binding site [ion binding]; metal-binding site 1283330008006 active site 1283330008007 I-site; other site 1283330008008 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283330008009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1283330008010 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1283330008011 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1283330008012 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330008013 Walker A/P-loop; other site 1283330008014 ATP binding site [chemical binding]; other site 1283330008015 Q-loop/lid; other site 1283330008016 ABC transporter signature motif; other site 1283330008017 Walker B; other site 1283330008018 D-loop; other site 1283330008019 H-loop/switch region; other site 1283330008020 ABC transporter; Region: ABC_tran_2; pfam12848 1283330008021 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283330008022 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1283330008023 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1283330008024 IscR-regulated protein YhgI; Region: YhgI_GntY; TIGR03341 1283330008025 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1283330008026 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 1283330008027 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1283330008028 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1283330008029 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1283330008030 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1283330008031 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283330008032 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283330008033 Strictosidine synthase; Region: Str_synth; pfam03088 1283330008034 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1283330008035 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1283330008036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1283330008037 Family of unknown function (DUF490); Region: DUF490; pfam04357 1283330008038 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1283330008039 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1283330008040 Surface antigen; Region: Bac_surface_Ag; pfam01103 1283330008041 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1283330008042 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1283330008043 putative catalytic site [active] 1283330008044 putative phosphate binding site [ion binding]; other site 1283330008045 active site 1283330008046 metal binding site A [ion binding]; metal-binding site 1283330008047 DNA binding site [nucleotide binding] 1283330008048 putative AP binding site [nucleotide binding]; other site 1283330008049 putative metal binding site B [ion binding]; other site 1283330008050 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1283330008051 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283330008052 ligand binding site [chemical binding]; other site 1283330008053 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1283330008054 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1283330008055 NAD(P) binding site [chemical binding]; other site 1283330008056 short chain dehydrogenase; Validated; Region: PRK06182 1283330008057 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1283330008058 NADP binding site [chemical binding]; other site 1283330008059 active site 1283330008060 steroid binding site; other site 1283330008061 Cupin; Region: Cupin_6; pfam12852 1283330008062 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1283330008063 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330008064 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1283330008065 major facilitator superfamily transporter; Provisional; Region: PRK05122 1283330008066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330008067 putative substrate translocation pore; other site 1283330008068 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1283330008069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330008070 active site 1283330008071 phosphorylation site [posttranslational modification] 1283330008072 intermolecular recognition site; other site 1283330008073 dimerization interface [polypeptide binding]; other site 1283330008074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330008075 Walker A motif; other site 1283330008076 ATP binding site [chemical binding]; other site 1283330008077 Walker B motif; other site 1283330008078 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330008079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330008080 dimer interface [polypeptide binding]; other site 1283330008081 phosphorylation site [posttranslational modification] 1283330008082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330008083 ATP binding site [chemical binding]; other site 1283330008084 Mg2+ binding site [ion binding]; other site 1283330008085 G-X-G motif; other site 1283330008086 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1283330008087 catalytic core [active] 1283330008088 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1283330008089 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1283330008090 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1283330008091 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1283330008092 active site 1 [active] 1283330008093 dimer interface [polypeptide binding]; other site 1283330008094 active site 2 [active] 1283330008095 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1283330008096 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1283330008097 dimer interface [polypeptide binding]; other site 1283330008098 active site 1283330008099 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1283330008100 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1283330008101 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1283330008102 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1283330008103 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1283330008104 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1283330008105 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283330008106 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1283330008107 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1283330008108 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1283330008109 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1283330008110 Walker A motif; other site 1283330008111 ATP binding site [chemical binding]; other site 1283330008112 Walker B motif; other site 1283330008113 Response regulator receiver domain; Region: Response_reg; pfam00072 1283330008114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330008115 active site 1283330008116 phosphorylation site [posttranslational modification] 1283330008117 intermolecular recognition site; other site 1283330008118 dimerization interface [polypeptide binding]; other site 1283330008119 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1283330008120 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1283330008121 motif 3; other site 1283330008122 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1283330008123 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 1283330008124 trimer interface [polypeptide binding]; other site 1283330008125 active site 1283330008126 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1283330008127 AMIN domain; Region: AMIN; pfam11741 1283330008128 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1283330008129 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1283330008130 active site 1283330008131 metal binding site [ion binding]; metal-binding site 1283330008132 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1283330008133 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1283330008134 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1283330008135 substrate binding pocket [chemical binding]; other site 1283330008136 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1283330008137 B12 binding site [chemical binding]; other site 1283330008138 cobalt ligand [ion binding]; other site 1283330008139 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1283330008140 Protein with unknown function (DUF469); Region: DUF469; pfam04320 1283330008141 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1283330008142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1283330008143 dimerization interface [polypeptide binding]; other site 1283330008144 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283330008145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330008146 dimer interface [polypeptide binding]; other site 1283330008147 phosphorylation site [posttranslational modification] 1283330008148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330008149 ATP binding site [chemical binding]; other site 1283330008150 Mg2+ binding site [ion binding]; other site 1283330008151 G-X-G motif; other site 1283330008152 Response regulator receiver domain; Region: Response_reg; pfam00072 1283330008153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330008154 active site 1283330008155 phosphorylation site [posttranslational modification] 1283330008156 intermolecular recognition site; other site 1283330008157 dimerization interface [polypeptide binding]; other site 1283330008158 Response regulator receiver domain; Region: Response_reg; pfam00072 1283330008159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330008160 active site 1283330008161 phosphorylation site [posttranslational modification] 1283330008162 intermolecular recognition site; other site 1283330008163 dimerization interface [polypeptide binding]; other site 1283330008164 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330008165 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330008166 metal binding site [ion binding]; metal-binding site 1283330008167 active site 1283330008168 I-site; other site 1283330008169 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1283330008170 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1283330008171 GIY-YIG motif/motif A; other site 1283330008172 active site 1283330008173 catalytic site [active] 1283330008174 putative DNA binding site [nucleotide binding]; other site 1283330008175 metal binding site [ion binding]; metal-binding site 1283330008176 hypothetical protein; Provisional; Region: PRK02487 1283330008177 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 1283330008178 ArsC family; Region: ArsC; pfam03960 1283330008179 putative catalytic residues [active] 1283330008180 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1283330008181 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14464 1283330008182 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1283330008183 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1283330008184 dimer interface [polypeptide binding]; other site 1283330008185 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1283330008186 metal binding site [ion binding]; metal-binding site 1283330008187 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283330008188 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330008189 substrate binding pocket [chemical binding]; other site 1283330008190 membrane-bound complex binding site; other site 1283330008191 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283330008192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330008193 putative PBP binding loops; other site 1283330008194 dimer interface [polypeptide binding]; other site 1283330008195 ABC-ATPase subunit interface; other site 1283330008196 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283330008197 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283330008198 Walker A/P-loop; other site 1283330008199 ATP binding site [chemical binding]; other site 1283330008200 Q-loop/lid; other site 1283330008201 ABC transporter signature motif; other site 1283330008202 Walker B; other site 1283330008203 D-loop; other site 1283330008204 H-loop/switch region; other site 1283330008205 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283330008206 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283330008207 active site 1283330008208 non-prolyl cis peptide bond; other site 1283330008209 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1283330008210 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1283330008211 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1283330008212 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1283330008213 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283330008214 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1283330008215 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1283330008216 FtsX-like permease family; Region: FtsX; pfam02687 1283330008217 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1283330008218 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1283330008219 Walker A/P-loop; other site 1283330008220 ATP binding site [chemical binding]; other site 1283330008221 Q-loop/lid; other site 1283330008222 ABC transporter signature motif; other site 1283330008223 Walker B; other site 1283330008224 D-loop; other site 1283330008225 H-loop/switch region; other site 1283330008226 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1283330008227 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1283330008228 active site 1283330008229 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1283330008230 malonyl-CoA binding site [chemical binding]; other site 1283330008231 dimer interface [polypeptide binding]; other site 1283330008232 active site 1283330008233 product binding site; other site 1283330008234 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1283330008235 2-Nitropropane dioxygenase (NPD)-like domain, associated with polyketide synthases (PKS). NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and...; Region: NPD_PKS; cd04743 1283330008236 FMN binding site [chemical binding]; other site 1283330008237 substrate binding site [chemical binding]; other site 1283330008238 putative catalytic residue [active] 1283330008239 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1283330008240 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1283330008241 active site 1283330008242 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1283330008243 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1283330008244 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330008245 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1283330008246 putative NADP binding site [chemical binding]; other site 1283330008247 active site 1283330008248 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1283330008249 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1283330008250 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1283330008251 homodimer interface [polypeptide binding]; other site 1283330008252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330008253 catalytic residue [active] 1283330008254 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1283330008255 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1283330008256 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1283330008257 active site 1283330008258 catalytic site [active] 1283330008259 substrate binding site [chemical binding]; other site 1283330008260 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1283330008261 RNA/DNA hybrid binding site [nucleotide binding]; other site 1283330008262 active site 1283330008263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330008264 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1283330008265 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1283330008266 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1283330008267 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1283330008268 catalytic residue [active] 1283330008269 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1283330008270 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1283330008271 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1283330008272 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1283330008273 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1283330008274 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1283330008275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330008276 dimer interface [polypeptide binding]; other site 1283330008277 conserved gate region; other site 1283330008278 putative PBP binding loops; other site 1283330008279 ABC-ATPase subunit interface; other site 1283330008280 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1283330008281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330008282 dimer interface [polypeptide binding]; other site 1283330008283 conserved gate region; other site 1283330008284 putative PBP binding loops; other site 1283330008285 ABC-ATPase subunit interface; other site 1283330008286 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1283330008287 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283330008288 Walker A/P-loop; other site 1283330008289 ATP binding site [chemical binding]; other site 1283330008290 Q-loop/lid; other site 1283330008291 ABC transporter signature motif; other site 1283330008292 Walker B; other site 1283330008293 D-loop; other site 1283330008294 H-loop/switch region; other site 1283330008295 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1283330008296 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283330008297 Walker A/P-loop; other site 1283330008298 ATP binding site [chemical binding]; other site 1283330008299 Q-loop/lid; other site 1283330008300 ABC transporter signature motif; other site 1283330008301 Walker B; other site 1283330008302 D-loop; other site 1283330008303 H-loop/switch region; other site 1283330008304 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1283330008305 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1283330008306 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1283330008307 NAD binding site [chemical binding]; other site 1283330008308 homotetramer interface [polypeptide binding]; other site 1283330008309 homodimer interface [polypeptide binding]; other site 1283330008310 substrate binding site [chemical binding]; other site 1283330008311 active site 1283330008312 xanthine permease; Region: pbuX; TIGR03173 1283330008313 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1283330008314 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1283330008315 EamA-like transporter family; Region: EamA; pfam00892 1283330008316 EamA-like transporter family; Region: EamA; pfam00892 1283330008317 Predicted membrane protein [Function unknown]; Region: COG3821 1283330008318 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1283330008319 CoA binding domain; Region: CoA_binding; pfam02629 1283330008320 CoA-ligase; Region: Ligase_CoA; pfam00549 1283330008321 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1283330008322 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1283330008323 CoA-ligase; Region: Ligase_CoA; pfam00549 1283330008324 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1283330008325 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1283330008326 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1283330008327 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1283330008328 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1283330008329 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1283330008330 E3 interaction surface; other site 1283330008331 lipoyl attachment site [posttranslational modification]; other site 1283330008332 e3 binding domain; Region: E3_binding; pfam02817 1283330008333 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1283330008334 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1283330008335 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1283330008336 TPP-binding site [chemical binding]; other site 1283330008337 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1283330008338 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1283330008339 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1283330008340 L-aspartate oxidase; Provisional; Region: PRK06175 1283330008341 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1283330008342 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1283330008343 SdhC subunit interface [polypeptide binding]; other site 1283330008344 proximal heme binding site [chemical binding]; other site 1283330008345 cardiolipin binding site; other site 1283330008346 Iron-sulfur protein interface; other site 1283330008347 proximal quinone binding site [chemical binding]; other site 1283330008348 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1283330008349 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1283330008350 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1283330008351 dimer interface [polypeptide binding]; other site 1283330008352 active site 1283330008353 citrylCoA binding site [chemical binding]; other site 1283330008354 NADH binding [chemical binding]; other site 1283330008355 cationic pore residues; other site 1283330008356 oxalacetate/citrate binding site [chemical binding]; other site 1283330008357 coenzyme A binding site [chemical binding]; other site 1283330008358 catalytic triad [active] 1283330008359 Flagellin N-methylase; Region: FliB; cl00497 1283330008360 Protein of unknown function, DUF486; Region: DUF486; pfam04342 1283330008361 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1283330008362 active site 1283330008363 catalytic site [active] 1283330008364 substrate binding site [chemical binding]; other site 1283330008365 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1283330008366 erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257 1283330008367 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1283330008368 ligand binding site [chemical binding]; other site 1283330008369 NAD binding site [chemical binding]; other site 1283330008370 catalytic site [active] 1283330008371 homodimer interface [polypeptide binding]; other site 1283330008372 multidrug efflux protein; Reviewed; Region: PRK01766 1283330008373 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1283330008374 cation binding site [ion binding]; other site 1283330008375 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1283330008376 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1283330008377 active site 1283330008378 tyrosine kinase; Provisional; Region: PRK11519 1283330008379 Chain length determinant protein; Region: Wzz; pfam02706 1283330008380 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1283330008381 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1283330008382 Nucleotide binding site [chemical binding]; other site 1283330008383 DTAP/Switch II; other site 1283330008384 Switch I; other site 1283330008385 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1283330008386 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283330008387 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1283330008388 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1283330008389 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 1283330008390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330008391 NAD(P) binding site [chemical binding]; other site 1283330008392 active site 1283330008393 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1283330008394 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1283330008395 Walker A/P-loop; other site 1283330008396 ATP binding site [chemical binding]; other site 1283330008397 Q-loop/lid; other site 1283330008398 ABC transporter signature motif; other site 1283330008399 Walker B; other site 1283330008400 D-loop; other site 1283330008401 H-loop/switch region; other site 1283330008402 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283330008403 active site 1283330008404 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1283330008405 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 1283330008406 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1283330008407 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1283330008408 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1283330008409 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1283330008410 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1283330008411 active site 1283330008412 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1283330008413 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1283330008414 Probable Catalytic site; other site 1283330008415 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1283330008416 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1283330008417 putative ADP-binding pocket [chemical binding]; other site 1283330008418 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1283330008419 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1283330008420 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1283330008421 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283330008422 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1283330008423 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283330008424 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1283330008425 putative ADP-binding pocket [chemical binding]; other site 1283330008426 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1283330008427 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1283330008428 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1283330008429 putative trimer interface [polypeptide binding]; other site 1283330008430 putative CoA binding site [chemical binding]; other site 1283330008431 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1283330008432 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1283330008433 inhibitor-cofactor binding pocket; inhibition site 1283330008434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330008435 catalytic residue [active] 1283330008436 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1283330008437 CoA binding domain; Region: CoA_binding; cl17356 1283330008438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330008439 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1283330008440 NAD(P) binding site [chemical binding]; other site 1283330008441 homodimer interface [polypeptide binding]; other site 1283330008442 substrate binding site [chemical binding]; other site 1283330008443 active site 1283330008444 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1283330008445 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1283330008446 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1283330008447 active site 1283330008448 putative glycosyl transferase; Provisional; Region: PRK10073 1283330008449 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1283330008450 active site 1283330008451 polysaccharide export protein Wza; Provisional; Region: PRK15078 1283330008452 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1283330008453 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05677 1283330008454 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1283330008455 acyl-activating enzyme (AAE) consensus motif; other site 1283330008456 putative AMP binding site [chemical binding]; other site 1283330008457 putative active site [active] 1283330008458 putative CoA binding site [chemical binding]; other site 1283330008459 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1283330008460 dimer interaction site [polypeptide binding]; other site 1283330008461 substrate-binding tunnel; other site 1283330008462 active site 1283330008463 catalytic site [active] 1283330008464 substrate binding site [chemical binding]; other site 1283330008465 cytosine deaminase; Provisional; Region: PRK09230 1283330008466 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1283330008467 active site 1283330008468 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1283330008469 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1283330008470 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283330008471 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330008472 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330008473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283330008474 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283330008475 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283330008476 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1283330008477 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1283330008478 Bacterial transcriptional regulator; Region: IclR; pfam01614 1283330008479 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 1283330008480 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1283330008481 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1283330008482 ATP-dependent helicase HepA; Validated; Region: PRK04914 1283330008483 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283330008484 ATP binding site [chemical binding]; other site 1283330008485 putative Mg++ binding site [ion binding]; other site 1283330008486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283330008487 nucleotide binding region [chemical binding]; other site 1283330008488 ATP-binding site [chemical binding]; other site 1283330008489 Ligase N family; Region: LIGANc; smart00532 1283330008490 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1283330008491 nucleotide binding pocket [chemical binding]; other site 1283330008492 K-X-D-G motif; other site 1283330008493 catalytic site [active] 1283330008494 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1283330008495 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1283330008496 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1283330008497 Dimer interface [polypeptide binding]; other site 1283330008498 BRCT sequence motif; other site 1283330008499 cell division protein ZipA; Reviewed; Region: zipA; PRK00269 1283330008500 Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115 1283330008501 FtsZ protein binding site [polypeptide binding]; other site 1283330008502 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1283330008503 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1283330008504 Walker A/P-loop; other site 1283330008505 ATP binding site [chemical binding]; other site 1283330008506 Q-loop/lid; other site 1283330008507 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1283330008508 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1283330008509 ABC transporter signature motif; other site 1283330008510 Walker B; other site 1283330008511 D-loop; other site 1283330008512 H-loop/switch region; other site 1283330008513 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 1283330008514 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283330008515 FeS/SAM binding site; other site 1283330008516 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1283330008517 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1283330008518 Ion channel; Region: Ion_trans_2; pfam07885 1283330008519 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1283330008520 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1283330008521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283330008522 binding surface 1283330008523 TPR motif; other site 1283330008524 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1283330008525 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1283330008526 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1283330008527 catalytic residues [active] 1283330008528 central insert; other site 1283330008529 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1283330008530 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1283330008531 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1283330008532 heme exporter protein CcmC; Region: ccmC; TIGR01191 1283330008533 heme exporter protein CcmB; Region: ccmB; TIGR01190 1283330008534 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1283330008535 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1283330008536 Walker A/P-loop; other site 1283330008537 ATP binding site [chemical binding]; other site 1283330008538 Q-loop/lid; other site 1283330008539 ABC transporter signature motif; other site 1283330008540 Walker B; other site 1283330008541 D-loop; other site 1283330008542 H-loop/switch region; other site 1283330008543 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1283330008544 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1283330008545 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1283330008546 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1283330008547 E-class dimer interface [polypeptide binding]; other site 1283330008548 P-class dimer interface [polypeptide binding]; other site 1283330008549 active site 1283330008550 Cu2+ binding site [ion binding]; other site 1283330008551 Zn2+ binding site [ion binding]; other site 1283330008552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330008553 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1283330008554 Walker A/P-loop; other site 1283330008555 ATP binding site [chemical binding]; other site 1283330008556 Q-loop/lid; other site 1283330008557 ABC transporter signature motif; other site 1283330008558 Walker B; other site 1283330008559 D-loop; other site 1283330008560 H-loop/switch region; other site 1283330008561 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283330008562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330008563 dimer interface [polypeptide binding]; other site 1283330008564 conserved gate region; other site 1283330008565 putative PBP binding loops; other site 1283330008566 ABC-ATPase subunit interface; other site 1283330008567 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1283330008568 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1283330008569 active site 1283330008570 dimer interface [polypeptide binding]; other site 1283330008571 non-prolyl cis peptide bond; other site 1283330008572 insertion regions; other site 1283330008573 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283330008574 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330008575 substrate binding pocket [chemical binding]; other site 1283330008576 membrane-bound complex binding site; other site 1283330008577 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1283330008578 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1283330008579 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1283330008580 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1283330008581 dimer interface [polypeptide binding]; other site 1283330008582 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1283330008583 catalytic triad [active] 1283330008584 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1283330008585 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1283330008586 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1283330008587 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1283330008588 dimerization interface [polypeptide binding]; other site 1283330008589 ligand binding site [chemical binding]; other site 1283330008590 NADP binding site [chemical binding]; other site 1283330008591 catalytic site [active] 1283330008592 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1283330008593 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1283330008594 active site 1283330008595 catalytic residues [active] 1283330008596 metal binding site [ion binding]; metal-binding site 1283330008597 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1283330008598 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1283330008599 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1283330008600 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1283330008601 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1283330008602 active site 1 [active] 1283330008603 dimer interface [polypeptide binding]; other site 1283330008604 hexamer interface [polypeptide binding]; other site 1283330008605 active site 2 [active] 1283330008606 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1283330008607 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1283330008608 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 1283330008609 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1283330008610 NAD binding site [chemical binding]; other site 1283330008611 catalytic residues [active] 1283330008612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330008613 non-specific DNA binding site [nucleotide binding]; other site 1283330008614 salt bridge; other site 1283330008615 sequence-specific DNA binding site [nucleotide binding]; other site 1283330008616 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1283330008617 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1283330008618 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1283330008619 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1283330008620 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 1283330008621 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1283330008622 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1283330008623 HicB family; Region: HicB; pfam05534 1283330008624 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1283330008625 ArsC family; Region: ArsC; pfam03960 1283330008626 catalytic residues [active] 1283330008627 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1283330008628 arsenical-resistance protein; Region: acr3; TIGR00832 1283330008629 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1283330008630 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1283330008631 active site 1283330008632 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283330008633 dimerization interface [polypeptide binding]; other site 1283330008634 putative DNA binding site [nucleotide binding]; other site 1283330008635 putative Zn2+ binding site [ion binding]; other site 1283330008636 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1283330008637 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283330008638 catalytic loop [active] 1283330008639 iron binding site [ion binding]; other site 1283330008640 Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211 1283330008641 FAD binding pocket [chemical binding]; other site 1283330008642 FAD binding motif [chemical binding]; other site 1283330008643 phosphate binding motif [ion binding]; other site 1283330008644 beta-alpha-beta structure motif; other site 1283330008645 NAD binding pocket [chemical binding]; other site 1283330008646 Phenol hydroxylase conserved region; Region: Phenol_monoox; pfam04663 1283330008647 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 1283330008648 dimerization interface [polypeptide binding]; other site 1283330008649 putative path to active site cavity [active] 1283330008650 diiron center [ion binding]; other site 1283330008651 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 1283330008652 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 1283330008653 dimerization interface [polypeptide binding]; other site 1283330008654 Phenol hydroxylase subunit; Region: Phenol_hyd_sub; pfam06099 1283330008655 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1283330008656 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 1283330008657 tetramer interface [polypeptide binding]; other site 1283330008658 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 1283330008659 tetramer interface [polypeptide binding]; other site 1283330008660 active site 1283330008661 Fe binding site [ion binding]; other site 1283330008662 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 1283330008663 putative uracil binding site [chemical binding]; other site 1283330008664 putative active site [active] 1283330008665 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330008666 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330008667 Activator of aromatic catabolism; Region: XylR_N; pfam06505 1283330008668 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 1283330008669 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1283330008670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330008671 Walker A motif; other site 1283330008672 ATP binding site [chemical binding]; other site 1283330008673 Walker B motif; other site 1283330008674 arginine finger; other site 1283330008675 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330008676 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1283330008677 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1283330008678 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1283330008679 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330008680 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the chlorocatechol catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_Chlorocatechol; cd08446 1283330008681 dimerization interface [polypeptide binding]; other site 1283330008682 putative substrate binding pocket [chemical binding]; other site 1283330008683 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283330008684 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330008685 N-terminal plug; other site 1283330008686 ligand-binding site [chemical binding]; other site 1283330008687 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1283330008688 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1283330008689 putative ligand binding residues [chemical binding]; other site 1283330008690 NMT1-like family; Region: NMT1_2; pfam13379 1283330008691 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283330008692 substrate binding pocket [chemical binding]; other site 1283330008693 membrane-bound complex binding site; other site 1283330008694 hinge residues; other site 1283330008695 malonic semialdehyde reductase; Provisional; Region: PRK10538 1283330008696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330008697 NAD(P) binding site [chemical binding]; other site 1283330008698 active site 1283330008699 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283330008700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330008701 putative PBP binding loops; other site 1283330008702 ABC-ATPase subunit interface; other site 1283330008703 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283330008704 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283330008705 Walker A/P-loop; other site 1283330008706 ATP binding site [chemical binding]; other site 1283330008707 Q-loop/lid; other site 1283330008708 ABC transporter signature motif; other site 1283330008709 Walker B; other site 1283330008710 D-loop; other site 1283330008711 H-loop/switch region; other site 1283330008712 NMT1-like family; Region: NMT1_2; pfam13379 1283330008713 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283330008714 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1283330008715 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1283330008716 active site 1283330008717 iron coordination sites [ion binding]; other site 1283330008718 substrate binding pocket [chemical binding]; other site 1283330008719 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1283330008720 active site residue [active] 1283330008721 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 1283330008722 active site residue [active] 1283330008723 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 1283330008724 active site residue [active] 1283330008725 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 1283330008726 active site residue [active] 1283330008727 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1283330008728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330008729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330008730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283330008731 dimerization interface [polypeptide binding]; other site 1283330008732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330008733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330008734 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283330008735 putative effector binding pocket; other site 1283330008736 dimerization interface [polypeptide binding]; other site 1283330008737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330008738 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1283330008739 NAD(P) binding site [chemical binding]; other site 1283330008740 active site 1283330008741 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1283330008742 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1283330008743 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1283330008744 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1283330008745 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1283330008746 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330008747 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 1283330008748 putative effector binding pocket; other site 1283330008749 putative dimerization interface [polypeptide binding]; other site 1283330008750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330008751 salt bridge; other site 1283330008752 non-specific DNA binding site [nucleotide binding]; other site 1283330008753 sequence-specific DNA binding site [nucleotide binding]; other site 1283330008754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1283330008755 non-specific DNA binding site [nucleotide binding]; other site 1283330008756 salt bridge; other site 1283330008757 sequence-specific DNA binding site [nucleotide binding]; other site 1283330008758 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1283330008759 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1283330008760 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1283330008761 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1283330008762 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1283330008763 active site 1283330008764 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1283330008765 NMT1/THI5 like; Region: NMT1; pfam09084 1283330008766 substrate binding pocket [chemical binding]; other site 1283330008767 membrane-bound complex binding site; other site 1283330008768 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283330008769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330008770 dimer interface [polypeptide binding]; other site 1283330008771 conserved gate region; other site 1283330008772 putative PBP binding loops; other site 1283330008773 ABC-ATPase subunit interface; other site 1283330008774 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283330008775 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283330008776 Walker A/P-loop; other site 1283330008777 ATP binding site [chemical binding]; other site 1283330008778 Q-loop/lid; other site 1283330008779 ABC transporter signature motif; other site 1283330008780 Walker B; other site 1283330008781 D-loop; other site 1283330008782 H-loop/switch region; other site 1283330008783 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283330008784 dimerization interface [polypeptide binding]; other site 1283330008785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330008786 dimer interface [polypeptide binding]; other site 1283330008787 phosphorylation site [posttranslational modification] 1283330008788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330008789 ATP binding site [chemical binding]; other site 1283330008790 Mg2+ binding site [ion binding]; other site 1283330008791 G-X-G motif; other site 1283330008792 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1283330008793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330008794 active site 1283330008795 phosphorylation site [posttranslational modification] 1283330008796 intermolecular recognition site; other site 1283330008797 dimerization interface [polypeptide binding]; other site 1283330008798 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283330008799 DNA binding site [nucleotide binding] 1283330008800 Bacterial SH3 domain; Region: SH3_3; pfam08239 1283330008801 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330008802 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1283330008803 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1283330008804 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1283330008805 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1283330008806 transcriptional activator TtdR; Provisional; Region: PRK09801 1283330008807 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330008808 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1283330008809 putative effector binding pocket; other site 1283330008810 putative dimerization interface [polypeptide binding]; other site 1283330008811 benzoate transport; Region: 2A0115; TIGR00895 1283330008812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330008813 putative substrate translocation pore; other site 1283330008814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330008815 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 1283330008816 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 1283330008817 putative active site [active] 1283330008818 Fe(II) binding site [ion binding]; other site 1283330008819 putative dimer interface [polypeptide binding]; other site 1283330008820 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 1283330008821 putative dimer interface [polypeptide binding]; other site 1283330008822 putative N- and C-terminal domain interface [polypeptide binding]; other site 1283330008823 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330008824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330008825 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1283330008826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330008827 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1283330008828 putative dimerization interface [polypeptide binding]; other site 1283330008829 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1283330008830 hypothetical protein; Provisional; Region: PRK09262 1283330008831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1283330008832 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330008833 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1283330008834 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1283330008835 dimer interface [polypeptide binding]; other site 1283330008836 active site 1283330008837 non-prolyl cis peptide bond; other site 1283330008838 insertion regions; other site 1283330008839 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1283330008840 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283330008841 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283330008842 active site 1283330008843 non-prolyl cis peptide bond; other site 1283330008844 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1283330008845 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283330008846 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283330008847 active site 1283330008848 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330008849 substrate binding pocket [chemical binding]; other site 1283330008850 membrane-bound complex binding site; other site 1283330008851 hinge residues; other site 1283330008852 aldolase II superfamily protein; Provisional; Region: PRK07044 1283330008853 active site 1283330008854 intersubunit interface [polypeptide binding]; other site 1283330008855 Zn2+ binding site [ion binding]; other site 1283330008856 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1283330008857 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283330008858 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330008859 membrane-bound complex binding site; other site 1283330008860 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283330008861 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330008862 membrane-bound complex binding site; other site 1283330008863 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1283330008864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330008865 Walker A motif; other site 1283330008866 ATP binding site [chemical binding]; other site 1283330008867 Walker B motif; other site 1283330008868 arginine finger; other site 1283330008869 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330008870 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1283330008871 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283330008872 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1283330008873 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1283330008874 Isochorismatase family; Region: Isochorismatase; pfam00857 1283330008875 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1283330008876 catalytic triad [active] 1283330008877 dimer interface [polypeptide binding]; other site 1283330008878 conserved cis-peptide bond; other site 1283330008879 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1283330008880 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1283330008881 active site 1283330008882 metal binding site [ion binding]; metal-binding site 1283330008883 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283330008884 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283330008885 active site 1283330008886 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283330008887 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1283330008888 Flavin binding site [chemical binding]; other site 1283330008889 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283330008890 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283330008891 active site 1283330008892 non-prolyl cis peptide bond; other site 1283330008893 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1283330008894 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1283330008895 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1283330008896 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1283330008897 Walker A/P-loop; other site 1283330008898 ATP binding site [chemical binding]; other site 1283330008899 Q-loop/lid; other site 1283330008900 ABC transporter signature motif; other site 1283330008901 Walker B; other site 1283330008902 D-loop; other site 1283330008903 H-loop/switch region; other site 1283330008904 NIL domain; Region: NIL; pfam09383 1283330008905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330008906 dimer interface [polypeptide binding]; other site 1283330008907 conserved gate region; other site 1283330008908 ABC-ATPase subunit interface; other site 1283330008909 transposase/IS protein; Provisional; Region: PRK09183 1283330008910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330008911 Walker A motif; other site 1283330008912 ATP binding site [chemical binding]; other site 1283330008913 Walker B motif; other site 1283330008914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1283330008915 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1283330008916 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 1283330008917 DNA binding site [nucleotide binding] 1283330008918 DNA-binding interface [nucleotide binding]; DNA binding site 1283330008919 domain linker motif; other site 1283330008920 Integrase core domain; Region: rve; pfam00665 1283330008921 Integrase core domain; Region: rve_3; cl15866 1283330008922 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1283330008923 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 1283330008924 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 1283330008925 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 1283330008926 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 1283330008927 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1283330008928 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 1283330008929 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1283330008930 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1283330008931 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1283330008932 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1283330008933 dimerization interface [polypeptide binding]; other site 1283330008934 substrate binding pocket [chemical binding]; other site 1283330008935 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330008936 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283330008937 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330008938 substrate binding pocket [chemical binding]; other site 1283330008939 membrane-bound complex binding site; other site 1283330008940 hinge residues; other site 1283330008941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330008942 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1283330008943 Walker A motif; other site 1283330008944 ATP binding site [chemical binding]; other site 1283330008945 Walker B motif; other site 1283330008946 Serine hydrolase; Region: Ser_hydrolase; pfam06821 1283330008947 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1283330008948 Uncharacterized small protein [Function unknown]; Region: COG5583 1283330008949 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1283330008950 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1283330008951 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1283330008952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330008953 dimer interface [polypeptide binding]; other site 1283330008954 conserved gate region; other site 1283330008955 putative PBP binding loops; other site 1283330008956 ABC-ATPase subunit interface; other site 1283330008957 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1283330008958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330008959 dimer interface [polypeptide binding]; other site 1283330008960 conserved gate region; other site 1283330008961 putative PBP binding loops; other site 1283330008962 ABC-ATPase subunit interface; other site 1283330008963 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1283330008964 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1283330008965 Walker A/P-loop; other site 1283330008966 ATP binding site [chemical binding]; other site 1283330008967 Q-loop/lid; other site 1283330008968 ABC transporter signature motif; other site 1283330008969 Walker B; other site 1283330008970 D-loop; other site 1283330008971 H-loop/switch region; other site 1283330008972 TOBE-like domain; Region: TOBE_3; pfam12857 1283330008973 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1283330008974 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1283330008975 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1283330008976 Alginate lyase; Region: Alginate_lyase2; pfam08787 1283330008977 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 1283330008978 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1283330008979 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1283330008980 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1283330008981 putative active site [active] 1283330008982 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1283330008983 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 1283330008984 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1283330008985 active site 1283330008986 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 1283330008987 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330008988 non-specific DNA binding site [nucleotide binding]; other site 1283330008989 salt bridge; other site 1283330008990 sequence-specific DNA binding site [nucleotide binding]; other site 1283330008991 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 1283330008992 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1283330008993 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1283330008994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330008995 non-specific DNA binding site [nucleotide binding]; other site 1283330008996 salt bridge; other site 1283330008997 sequence-specific DNA binding site [nucleotide binding]; other site 1283330008998 Tim44-like domain; Region: Tim44; cl09208 1283330008999 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 1283330009000 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 1283330009001 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 1283330009002 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1283330009003 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1283330009004 flavodoxin FldA; Validated; Region: PRK09267 1283330009005 Protein of unknown function (DUF2023); Region: DUF2023; pfam09633 1283330009006 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1283330009007 Phage Tail Protein X; Region: Phage_tail_X; cl02088 1283330009008 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1283330009009 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1283330009010 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1283330009011 Flavin binding site [chemical binding]; other site 1283330009012 Transposase domain (DUF772); Region: DUF772; pfam05598 1283330009013 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283330009014 DDE superfamily endonuclease; Region: DDE_4; cl17710 1283330009015 MarR family; Region: MarR_2; cl17246 1283330009016 succinic semialdehyde dehydrogenase; Region: PLN02278 1283330009017 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1283330009018 tetramerization interface [polypeptide binding]; other site 1283330009019 NAD(P) binding site [chemical binding]; other site 1283330009020 catalytic residues [active] 1283330009021 D-galactonate transporter; Region: 2A0114; TIGR00893 1283330009022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330009023 putative substrate translocation pore; other site 1283330009024 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1283330009025 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1283330009026 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330009027 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283330009028 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330009029 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330009030 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1283330009031 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 1283330009032 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1283330009033 catalytic site [active] 1283330009034 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1283330009035 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1283330009036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330009037 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1283330009038 putative substrate translocation pore; other site 1283330009039 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1283330009040 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1283330009041 putative NAD(P) binding site [chemical binding]; other site 1283330009042 putative substrate binding site [chemical binding]; other site 1283330009043 catalytic Zn binding site [ion binding]; other site 1283330009044 structural Zn binding site [ion binding]; other site 1283330009045 dimer interface [polypeptide binding]; other site 1283330009046 RES domain; Region: RES; smart00953 1283330009047 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1283330009048 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1283330009049 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1283330009050 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1283330009051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330009052 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1283330009053 NAD(P) binding site [chemical binding]; other site 1283330009054 active site 1283330009055 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1283330009056 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330009057 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1283330009058 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330009059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330009060 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1283330009061 putative effector binding pocket; other site 1283330009062 putative dimerization interface [polypeptide binding]; other site 1283330009063 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330009064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330009065 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1283330009066 putative effector binding pocket; other site 1283330009067 putative dimerization interface [polypeptide binding]; other site 1283330009068 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283330009069 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283330009070 active site 1283330009071 catalytic tetrad [active] 1283330009072 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1283330009073 short chain dehydrogenase; Provisional; Region: PRK06180 1283330009074 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1283330009075 NADP binding site [chemical binding]; other site 1283330009076 active site 1283330009077 steroid binding site; other site 1283330009078 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283330009079 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283330009080 active site 1283330009081 catalytic tetrad [active] 1283330009082 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283330009083 active site 1283330009084 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283330009085 catalytic tetrad [active] 1283330009086 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1283330009087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1283330009088 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283330009089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330009090 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1283330009091 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1283330009092 FMN binding site [chemical binding]; other site 1283330009093 active site 1283330009094 catalytic residues [active] 1283330009095 substrate binding site [chemical binding]; other site 1283330009096 transaldolase-like protein; Provisional; Region: PTZ00411 1283330009097 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1283330009098 active site 1283330009099 dimer interface [polypeptide binding]; other site 1283330009100 catalytic residue [active] 1283330009101 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1283330009102 anti sigma factor interaction site; other site 1283330009103 regulatory phosphorylation site [posttranslational modification]; other site 1283330009104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330009105 active site 1283330009106 phosphorylation site [posttranslational modification] 1283330009107 intermolecular recognition site; other site 1283330009108 dimerization interface [polypeptide binding]; other site 1283330009109 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1283330009110 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1283330009111 VacJ like lipoprotein; Region: VacJ; cl01073 1283330009112 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 1283330009113 MASE2 domain; Region: MASE2; pfam05230 1283330009114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1283330009115 cyclase homology domain; Region: CHD; cd07302 1283330009116 nucleotidyl binding site; other site 1283330009117 metal binding site [ion binding]; metal-binding site 1283330009118 dimer interface [polypeptide binding]; other site 1283330009119 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283330009120 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1283330009121 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1283330009122 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1283330009123 putative active site [active] 1283330009124 putative metal binding site [ion binding]; other site 1283330009125 Uncharacterized protein conserved in bacteria [Posttranslational modification, protein turnover, chaperones]; Region: COG3526 1283330009126 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1283330009127 MarR family; Region: MarR_2; pfam12802 1283330009128 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1283330009129 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283330009130 ATP binding site [chemical binding]; other site 1283330009131 putative Mg++ binding site [ion binding]; other site 1283330009132 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283330009133 nucleotide binding region [chemical binding]; other site 1283330009134 ATP-binding site [chemical binding]; other site 1283330009135 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1283330009136 HRDC domain; Region: HRDC; pfam00570 1283330009137 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1283330009138 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1283330009139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1283330009140 DTW domain; Region: DTW; cl01221 1283330009141 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1283330009142 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1283330009143 dimer interface [polypeptide binding]; other site 1283330009144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330009145 catalytic residue [active] 1283330009146 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1283330009147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330009148 Walker A motif; other site 1283330009149 ATP binding site [chemical binding]; other site 1283330009150 Walker B motif; other site 1283330009151 arginine finger; other site 1283330009152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1283330009153 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1283330009154 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1283330009155 putative active site [active] 1283330009156 putative dimer interface [polypeptide binding]; other site 1283330009157 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1283330009158 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283330009159 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1283330009160 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1283330009161 hypothetical protein; Provisional; Region: PRK05170 1283330009162 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1283330009163 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1283330009164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1283330009165 ribonuclease D; Region: rnd; TIGR01388 1283330009166 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1283330009167 catalytic site [active] 1283330009168 putative active site [active] 1283330009169 putative substrate binding site [chemical binding]; other site 1283330009170 HRDC domain; Region: HRDC; cl02578 1283330009171 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1283330009172 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1283330009173 active site residue [active] 1283330009174 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1283330009175 active site residue [active] 1283330009176 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1283330009177 dimerization interface [polypeptide binding]; other site 1283330009178 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1283330009179 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1283330009180 catalytic core [active] 1283330009181 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1283330009182 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1283330009183 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1283330009184 putative dimer interface [polypeptide binding]; other site 1283330009185 active site pocket [active] 1283330009186 putative cataytic base [active] 1283330009187 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1283330009188 homotrimer interface [polypeptide binding]; other site 1283330009189 Walker A motif; other site 1283330009190 GTP binding site [chemical binding]; other site 1283330009191 Walker B motif; other site 1283330009192 cobyric acid synthase; Provisional; Region: PRK00784 1283330009193 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1283330009194 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1283330009195 catalytic triad [active] 1283330009196 threonine-phosphate decarboxylase; Reviewed; Region: PRK05664 1283330009197 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1283330009198 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283330009199 catalytic residue [active] 1283330009200 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1283330009201 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1283330009202 FMN binding site [chemical binding]; other site 1283330009203 dimer interface [polypeptide binding]; other site 1283330009204 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1283330009205 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283330009206 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1283330009207 catalytic triad [active] 1283330009208 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 1283330009209 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330009210 N-terminal plug; other site 1283330009211 ligand-binding site [chemical binding]; other site 1283330009212 NAD-dependent deacetylase; Provisional; Region: PRK00481 1283330009213 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1283330009214 NAD+ binding site [chemical binding]; other site 1283330009215 substrate binding site [chemical binding]; other site 1283330009216 Zn binding site [ion binding]; other site 1283330009217 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1283330009218 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1283330009219 catalytic triad [active] 1283330009220 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1283330009221 NlpC/P60 family; Region: NLPC_P60; pfam00877 1283330009222 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1283330009223 NlpC/P60 family; Region: NLPC_P60; pfam00877 1283330009224 NAD-dependent deacetylase; Provisional; Region: PRK00481 1283330009225 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1283330009226 NAD+ binding site [chemical binding]; other site 1283330009227 substrate binding site [chemical binding]; other site 1283330009228 Zn binding site [ion binding]; other site 1283330009229 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1283330009230 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1283330009231 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1283330009232 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1283330009233 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1283330009234 Ligand Binding Site [chemical binding]; other site 1283330009235 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1283330009236 hypothetical protein; Provisional; Region: PRK04860 1283330009237 SprT homologues; Region: SprT; cl01182 1283330009238 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1283330009239 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1283330009240 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1283330009241 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1283330009242 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283330009243 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1283330009244 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1283330009245 ATP cone domain; Region: ATP-cone; pfam03477 1283330009246 ATP cone domain; Region: ATP-cone; pfam03477 1283330009247 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1283330009248 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1283330009249 protein-splicing catalytic site; other site 1283330009250 thioester formation/cholesterol transfer; other site 1283330009251 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1283330009252 R2 peptide binding site; other site 1283330009253 catalytic residues [active] 1283330009254 active site 1283330009255 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1283330009256 dimer interface [polypeptide binding]; other site 1283330009257 putative radical transfer pathway; other site 1283330009258 diiron center [ion binding]; other site 1283330009259 tyrosyl radical; other site 1283330009260 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283330009261 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283330009262 Transposase IS200 like; Region: Y1_Tnp; cl00848 1283330009263 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1283330009264 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1283330009265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330009266 S-adenosylmethionine binding site [chemical binding]; other site 1283330009267 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 1283330009268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330009269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330009270 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1283330009271 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1283330009272 TOBE domain; Region: TOBE; cl01440 1283330009273 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1283330009274 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1283330009275 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1283330009276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330009277 Walker A motif; other site 1283330009278 ATP binding site [chemical binding]; other site 1283330009279 Walker B motif; other site 1283330009280 arginine finger; other site 1283330009281 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330009282 Integrase core domain; Region: rve_3; pfam13683 1283330009283 Integral membrane protein TerC family; Region: TerC; cl10468 1283330009284 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 1283330009285 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1283330009286 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283330009287 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283330009288 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330009289 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330009290 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1283330009291 Integrase core domain; Region: rve; pfam00665 1283330009292 Integrase core domain; Region: rve_3; pfam13683 1283330009293 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330009294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330009295 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 1283330009296 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 1283330009297 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283330009298 trimer interface; other site 1283330009299 sugar binding site [chemical binding]; other site 1283330009300 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1283330009301 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1283330009302 Cytochrome c; Region: Cytochrom_C; pfam00034 1283330009303 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1283330009304 TrkA-N domain; Region: TrkA_N; pfam02254 1283330009305 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1283330009306 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1283330009307 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1283330009308 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283330009309 DNA binding site [nucleotide binding] 1283330009310 domain linker motif; other site 1283330009311 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 1283330009312 putative dimerization interface [polypeptide binding]; other site 1283330009313 putative ligand binding site [chemical binding]; other site 1283330009314 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1283330009315 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1283330009316 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1283330009317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330009318 putative substrate translocation pore; other site 1283330009319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330009320 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1283330009321 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1283330009322 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283330009323 Right handed beta helix region; Region: Beta_helix; pfam13229 1283330009324 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1283330009325 Transposase; Region: HTH_Tnp_1; cl17663 1283330009326 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330009327 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330009328 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283330009329 dimerization interface [polypeptide binding]; other site 1283330009330 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283330009331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330009332 putative substrate translocation pore; other site 1283330009333 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1283330009334 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130 1283330009335 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283330009336 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1283330009337 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1283330009338 dimer interface [polypeptide binding]; other site 1283330009339 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1283330009340 active site 1283330009341 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 1283330009342 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1283330009343 putative NAD(P) binding site [chemical binding]; other site 1283330009344 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330009345 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330009346 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1283330009347 putative substrate binding pocket [chemical binding]; other site 1283330009348 putative dimerization interface [polypeptide binding]; other site 1283330009349 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1283330009350 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283330009351 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283330009352 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1283330009353 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1283330009354 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1283330009355 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1283330009356 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283330009357 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283330009358 active site 1283330009359 catalytic tetrad [active] 1283330009360 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1283330009361 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1283330009362 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283330009363 DNA binding site [nucleotide binding] 1283330009364 domain linker motif; other site 1283330009365 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1283330009366 putative dimerization interface [polypeptide binding]; other site 1283330009367 putative ligand binding site [chemical binding]; other site 1283330009368 hypothetical protein; Provisional; Region: PRK06847 1283330009369 Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867 1283330009370 substrate binding pocket [chemical binding]; other site 1283330009371 substrate-Mg2+ binding site; other site 1283330009372 aspartate-rich region 1; other site 1283330009373 aspartate-rich region 2; other site 1283330009374 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330009375 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1283330009376 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1283330009377 active site 1283330009378 metal binding site [ion binding]; metal-binding site 1283330009379 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01231 1283330009380 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1283330009381 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 1283330009382 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1283330009383 oxidoreductase; Validated; Region: PRK05717 1283330009384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330009385 NAD(P) binding site [chemical binding]; other site 1283330009386 active site 1283330009387 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 1283330009388 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1283330009389 homodimer interface [polypeptide binding]; other site 1283330009390 substrate-cofactor binding pocket; other site 1283330009391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330009392 catalytic residue [active] 1283330009393 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1283330009394 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1283330009395 active site 1283330009396 tetramer interface [polypeptide binding]; other site 1283330009397 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283330009398 active site 1283330009399 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1283330009400 Colicin V production protein; Region: Colicin_V; cl00567 1283330009401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 1283330009402 Sporulation related domain; Region: SPOR; pfam05036 1283330009403 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1283330009404 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1283330009405 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1283330009406 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1283330009407 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1283330009408 active site 1283330009409 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1283330009410 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1283330009411 dimerization interface 3.5A [polypeptide binding]; other site 1283330009412 active site 1283330009413 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 1283330009414 FimV N-terminal domain; Region: FimV_core; TIGR03505 1283330009415 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 1283330009416 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK05671 1283330009417 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1283330009418 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1283330009419 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1283330009420 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1283330009421 tartrate dehydrogenase; Region: TTC; TIGR02089 1283330009422 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1283330009423 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1283330009424 substrate binding site [chemical binding]; other site 1283330009425 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1283330009426 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1283330009427 substrate binding site [chemical binding]; other site 1283330009428 ligand binding site [chemical binding]; other site 1283330009429 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330009430 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330009431 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283330009432 dimerization interface [polypeptide binding]; other site 1283330009433 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1283330009434 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1283330009435 putative dimer interface [polypeptide binding]; other site 1283330009436 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 1283330009437 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1283330009438 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1283330009439 FMN binding site [chemical binding]; other site 1283330009440 active site 1283330009441 catalytic residues [active] 1283330009442 substrate binding site [chemical binding]; other site 1283330009443 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1283330009444 active site 1283330009445 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1283330009446 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1283330009447 active site 1283330009448 intersubunit interface [polypeptide binding]; other site 1283330009449 catalytic residue [active] 1283330009450 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1283330009451 Response regulator receiver domain; Region: Response_reg; pfam00072 1283330009452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330009453 active site 1283330009454 phosphorylation site [posttranslational modification] 1283330009455 intermolecular recognition site; other site 1283330009456 dimerization interface [polypeptide binding]; other site 1283330009457 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1283330009458 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1283330009459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330009460 ATP binding site [chemical binding]; other site 1283330009461 Mg2+ binding site [ion binding]; other site 1283330009462 G-X-G motif; other site 1283330009463 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1283330009464 anti sigma factor interaction site; other site 1283330009465 regulatory phosphorylation site [posttranslational modification]; other site 1283330009466 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1283330009467 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 1283330009468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330009469 Walker A motif; other site 1283330009470 ATP binding site [chemical binding]; other site 1283330009471 Walker B motif; other site 1283330009472 arginine finger; other site 1283330009473 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1283330009474 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1283330009475 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1283330009476 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1283330009477 Arc-like DNA binding domain; Region: Arc; pfam03869 1283330009478 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1283330009479 MgtE intracellular N domain; Region: MgtE_N; smart00924 1283330009480 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1283330009481 Divalent cation transporter; Region: MgtE; cl00786 1283330009482 Global regulator protein family; Region: CsrA; cl00670 1283330009483 aspartate kinase; Reviewed; Region: PRK06635 1283330009484 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1283330009485 putative nucleotide binding site [chemical binding]; other site 1283330009486 putative catalytic residues [active] 1283330009487 putative Mg ion binding site [ion binding]; other site 1283330009488 putative aspartate binding site [chemical binding]; other site 1283330009489 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1283330009490 putative allosteric regulatory site; other site 1283330009491 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1283330009492 putative allosteric regulatory residue; other site 1283330009493 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1283330009494 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1283330009495 motif 1; other site 1283330009496 active site 1283330009497 motif 2; other site 1283330009498 motif 3; other site 1283330009499 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1283330009500 DHHA1 domain; Region: DHHA1; pfam02272 1283330009501 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1283330009502 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1283330009503 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1283330009504 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1283330009505 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1283330009506 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1283330009507 inhibitor-cofactor binding pocket; inhibition site 1283330009508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330009509 catalytic residue [active] 1283330009510 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1283330009511 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 1283330009512 conserved cys residue [active] 1283330009513 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330009514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330009515 acetyl-CoA synthetase; Provisional; Region: PRK00174 1283330009516 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1283330009517 active site 1283330009518 CoA binding site [chemical binding]; other site 1283330009519 acyl-activating enzyme (AAE) consensus motif; other site 1283330009520 AMP binding site [chemical binding]; other site 1283330009521 acetate binding site [chemical binding]; other site 1283330009522 phosphate acetyltransferase; Reviewed; Region: PRK05632 1283330009523 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283330009524 DRTGG domain; Region: DRTGG; pfam07085 1283330009525 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1283330009526 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1283330009527 propionate/acetate kinase; Provisional; Region: PRK12379 1283330009528 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1283330009529 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1283330009530 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1283330009531 dinuclear metal binding motif [ion binding]; other site 1283330009532 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 1283330009533 cofactor binding site; other site 1283330009534 metal binding site [ion binding]; metal-binding site 1283330009535 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 1283330009536 aromatic arch; other site 1283330009537 DCoH dimer interaction site [polypeptide binding]; other site 1283330009538 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1283330009539 DCoH tetramer interaction site [polypeptide binding]; other site 1283330009540 substrate binding site [chemical binding]; other site 1283330009541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330009542 putative MFS family transporter protein; Provisional; Region: PRK03633 1283330009543 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 1283330009544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330009545 active site 1283330009546 motif I; other site 1283330009547 motif II; other site 1283330009548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330009549 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1283330009550 glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398 1283330009551 active site 1283330009552 homotetramer interface [polypeptide binding]; other site 1283330009553 hypothetical protein; Provisional; Region: PRK09256 1283330009554 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1283330009555 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 1283330009556 Dienelactone hydrolase family; Region: DLH; pfam01738 1283330009557 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1283330009558 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1283330009559 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1283330009560 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1283330009561 dimer interface [polypeptide binding]; other site 1283330009562 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1283330009563 active site 1283330009564 Fe binding site [ion binding]; other site 1283330009565 BON domain; Region: BON; pfam04972 1283330009566 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 1283330009567 putative hydrophobic ligand binding site [chemical binding]; other site 1283330009568 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1283330009569 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 1283330009570 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283330009571 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562 1283330009572 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283330009573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330009574 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1283330009575 Walker A/P-loop; other site 1283330009576 ATP binding site [chemical binding]; other site 1283330009577 Q-loop/lid; other site 1283330009578 ABC transporter signature motif; other site 1283330009579 Walker B; other site 1283330009580 D-loop; other site 1283330009581 H-loop/switch region; other site 1283330009582 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1283330009583 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1283330009584 catalytic residues [active] 1283330009585 BolA-like protein; Region: BolA; pfam01722 1283330009586 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 1283330009587 fumarate hydratase; Provisional; Region: PRK12425 1283330009588 Class II fumarases; Region: Fumarase_classII; cd01362 1283330009589 active site 1283330009590 tetramer interface [polypeptide binding]; other site 1283330009591 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1283330009592 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1283330009593 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 1283330009594 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1283330009595 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1283330009596 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283330009597 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1283330009598 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1283330009599 MarR family; Region: MarR_2; cl17246 1283330009600 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1283330009601 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1283330009602 active site 1283330009603 dimer interface [polypeptide binding]; other site 1283330009604 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1283330009605 Ligand Binding Site [chemical binding]; other site 1283330009606 Molecular Tunnel; other site 1283330009607 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1283330009608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1283330009609 Coenzyme A binding pocket [chemical binding]; other site 1283330009610 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1283330009611 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1283330009612 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1283330009613 putative oligomer interface [polypeptide binding]; other site 1283330009614 putative active site [active] 1283330009615 metal binding site [ion binding]; metal-binding site 1283330009616 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1283330009617 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1283330009618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330009619 dimer interface [polypeptide binding]; other site 1283330009620 phosphorylation site [posttranslational modification] 1283330009621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330009622 ATP binding site [chemical binding]; other site 1283330009623 Mg2+ binding site [ion binding]; other site 1283330009624 G-X-G motif; other site 1283330009625 Response regulator receiver domain; Region: Response_reg; pfam00072 1283330009626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330009627 active site 1283330009628 phosphorylation site [posttranslational modification] 1283330009629 intermolecular recognition site; other site 1283330009630 dimerization interface [polypeptide binding]; other site 1283330009631 hypothetical protein; Provisional; Region: PRK00304 1283330009632 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1283330009633 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1283330009634 Domain of unknown function DUF21; Region: DUF21; pfam01595 1283330009635 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1283330009636 Transporter associated domain; Region: CorC_HlyC; smart01091 1283330009637 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1283330009638 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1283330009639 Na binding site [ion binding]; other site 1283330009640 Predicted membrane protein [Function unknown]; Region: COG3162 1283330009641 Predicted membrane protein [Function unknown]; Region: COG3205 1283330009642 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1283330009643 VacJ like lipoprotein; Region: VacJ; cl01073 1283330009644 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1283330009645 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1283330009646 putative acyl-acceptor binding pocket; other site 1283330009647 septum formation inhibitor; Reviewed; Region: minC; PRK00339 1283330009648 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1283330009649 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1283330009650 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1283330009651 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1283330009652 Switch I; other site 1283330009653 Switch II; other site 1283330009654 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1283330009655 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1283330009656 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1283330009657 active site 1283330009658 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1283330009659 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1283330009660 active site 1283330009661 metal binding site [ion binding]; metal-binding site 1283330009662 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1283330009663 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1283330009664 NAD(P) binding site [chemical binding]; other site 1283330009665 carboxy-terminal protease; Provisional; Region: PRK11186 1283330009666 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1283330009667 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1283330009668 protein binding site [polypeptide binding]; other site 1283330009669 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1283330009670 Catalytic dyad [active] 1283330009671 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1283330009672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330009673 non-specific DNA binding site [nucleotide binding]; other site 1283330009674 salt bridge; other site 1283330009675 sequence-specific DNA binding site [nucleotide binding]; other site 1283330009676 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1283330009677 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1283330009678 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1283330009679 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1283330009680 recombination associated protein; Reviewed; Region: rdgC; PRK00321 1283330009681 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1283330009682 Na binding site [ion binding]; other site 1283330009683 PAS domain; Region: PAS; smart00091 1283330009684 PAS fold; Region: PAS_7; pfam12860 1283330009685 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283330009686 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330009687 dimer interface [polypeptide binding]; other site 1283330009688 phosphorylation site [posttranslational modification] 1283330009689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330009690 ATP binding site [chemical binding]; other site 1283330009691 Mg2+ binding site [ion binding]; other site 1283330009692 G-X-G motif; other site 1283330009693 Response regulator receiver domain; Region: Response_reg; pfam00072 1283330009694 Predicted membrane protein [Function unknown]; Region: COG3174 1283330009695 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 1283330009696 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1283330009697 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 1283330009698 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1283330009699 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 1283330009700 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1283330009701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330009702 S-adenosylmethionine binding site [chemical binding]; other site 1283330009703 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1283330009704 ATP binding site [chemical binding]; other site 1283330009705 active site 1283330009706 substrate binding site [chemical binding]; other site 1283330009707 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1283330009708 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1283330009709 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1283330009710 dimer interface [polypeptide binding]; other site 1283330009711 active site 1283330009712 catalytic residue [active] 1283330009713 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1283330009714 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1283330009715 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 1283330009716 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1283330009717 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1283330009718 catalytic triad [active] 1283330009719 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1283330009720 CPxP motif; other site 1283330009721 Peptidase family M48; Region: Peptidase_M48; cl12018 1283330009722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1283330009723 binding surface 1283330009724 TPR motif; other site 1283330009725 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1283330009726 quinolinate synthetase; Provisional; Region: PRK09375 1283330009727 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1283330009728 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1283330009729 transmembrane helices; other site 1283330009730 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 1283330009731 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1283330009732 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1283330009733 putative NAD(P) binding site [chemical binding]; other site 1283330009734 putative substrate binding site [chemical binding]; other site 1283330009735 catalytic Zn binding site [ion binding]; other site 1283330009736 structural Zn binding site [ion binding]; other site 1283330009737 dimer interface [polypeptide binding]; other site 1283330009738 classical (c) SDRs; Region: SDR_c; cd05233 1283330009739 NAD(P) binding site [chemical binding]; other site 1283330009740 active site 1283330009741 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330009742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330009743 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1283330009744 putative effector binding pocket; other site 1283330009745 putative dimerization interface [polypeptide binding]; other site 1283330009746 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1283330009747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330009748 putative substrate translocation pore; other site 1283330009749 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330009750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330009751 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1283330009752 putative effector binding pocket; other site 1283330009753 putative dimerization interface [polypeptide binding]; other site 1283330009754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283330009755 FeS/SAM binding site; other site 1283330009756 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1283330009757 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1283330009758 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1283330009759 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1283330009760 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1283330009761 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283330009762 catalytic loop [active] 1283330009763 iron binding site [ion binding]; other site 1283330009764 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1283330009765 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1283330009766 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283330009767 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1283330009768 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283330009769 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1283330009770 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1283330009771 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1283330009772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283330009773 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283330009774 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283330009775 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 1283330009776 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283330009777 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 1283330009778 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1283330009779 VirB7 interaction site; other site 1283330009780 conjugal transfer protein TrbF; Provisional; Region: PRK13872 1283330009781 conjugal transfer protein TrbL; Provisional; Region: PRK13875 1283330009782 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 1283330009783 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 1283330009784 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 1283330009785 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 1283330009786 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1283330009787 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1283330009788 Walker A motif; other site 1283330009789 ATP binding site [chemical binding]; other site 1283330009790 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1283330009791 Type IV secretory pathway, TrbD component [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TrbD; COG5268 1283330009792 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 1283330009793 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 1283330009794 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1283330009795 ATP binding site [chemical binding]; other site 1283330009796 Walker A motif; other site 1283330009797 hexamer interface [polypeptide binding]; other site 1283330009798 Walker B motif; other site 1283330009799 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 1283330009800 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1283330009801 Walker A motif; other site 1283330009802 ATP binding site [chemical binding]; other site 1283330009803 Walker B motif; other site 1283330009804 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330009805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330009806 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1283330009807 dimerization interface [polypeptide binding]; other site 1283330009808 substrate binding pocket [chemical binding]; other site 1283330009809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330009810 putative substrate translocation pore; other site 1283330009811 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283330009812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330009813 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283330009814 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283330009815 Major royal jelly protein; Region: MRJP; pfam03022 1283330009816 SnoaL-like domain; Region: SnoaL_2; pfam12680 1283330009817 SnoaL-like domain; Region: SnoaL_2; pfam12680 1283330009818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283330009819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283330009820 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1283330009821 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1283330009822 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330009823 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330009824 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283330009825 dimerization interface [polypeptide binding]; other site 1283330009826 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330009827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330009828 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1283330009829 dimerization interface [polypeptide binding]; other site 1283330009830 substrate binding pocket [chemical binding]; other site 1283330009831 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283330009832 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283330009833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330009834 putative substrate translocation pore; other site 1283330009835 Beta-lactamase; Region: Beta-lactamase; pfam00144 1283330009836 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1283330009837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330009838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330009839 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 1283330009840 putative dimerization interface [polypeptide binding]; other site 1283330009841 putative effector binding pocket; other site 1283330009842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330009843 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283330009844 putative substrate translocation pore; other site 1283330009845 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330009846 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330009847 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283330009848 dimerization interface [polypeptide binding]; other site 1283330009849 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 1283330009850 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 1283330009851 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 1283330009852 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 1283330009853 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 1283330009854 ParA-like protein; Provisional; Region: PHA02518 1283330009855 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1283330009856 P-loop; other site 1283330009857 Magnesium ion binding site [ion binding]; other site 1283330009858 Replication initiator protein A; Region: RPA; pfam10134 1283330009859 Helix-turn-helix domain; Region: HTH_17; cl17695 1283330009860 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 1283330009861 Protein of unknown function (DUF2958); Region: DUF2958; pfam11171 1283330009862 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1283330009863 sequence-specific DNA binding site [nucleotide binding]; other site 1283330009864 salt bridge; other site 1283330009865 Protein of unknown function (DUF736); Region: DUF736; cl02303 1283330009866 hypothetical protein; Reviewed; Region: PRK00024 1283330009867 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1283330009868 MPN+ (JAMM) motif; other site 1283330009869 Zinc-binding site [ion binding]; other site 1283330009870 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1283330009871 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1283330009872 cofactor binding site; other site 1283330009873 DNA binding site [nucleotide binding] 1283330009874 substrate interaction site [chemical binding]; other site 1283330009875 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1283330009876 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1283330009877 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1283330009878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330009879 ATP binding site [chemical binding]; other site 1283330009880 G-X-G motif; other site 1283330009881 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1283330009882 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1283330009883 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1283330009884 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1283330009885 active site 1283330009886 Int/Topo IB signature motif; other site 1283330009887 DNA binding site [nucleotide binding] 1283330009888 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330009889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330009890 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 1283330009891 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1283330009892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283330009893 DNA-binding site [nucleotide binding]; DNA binding site 1283330009894 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283330009895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330009896 homodimer interface [polypeptide binding]; other site 1283330009897 catalytic residue [active] 1283330009898 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283330009899 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283330009900 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1283330009901 oligomeric interface; other site 1283330009902 putative active site [active] 1283330009903 homodimer interface [polypeptide binding]; other site 1283330009904 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1283330009905 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 1283330009906 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 1283330009907 Protein of unknown function (DUF3262); Region: DUF3262; pfam11660 1283330009908 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 1283330009909 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 1283330009910 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 1283330009911 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 1283330009912 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 1283330009913 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1283330009914 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 1283330009915 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 1283330009916 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 1283330009917 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1283330009918 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1283330009919 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1283330009920 catalytic residues [active] 1283330009921 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1283330009922 active site 1283330009923 ATP binding site [chemical binding]; other site 1283330009924 substrate binding site [chemical binding]; other site 1283330009925 activation loop (A-loop); other site 1283330009926 Protein of unknown function (DUF1525); Region: DUF1525; pfam07511 1283330009927 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 1283330009928 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 1283330009929 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 1283330009930 PemK-like protein; Region: PemK; pfam02452 1283330009931 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1283330009932 Homeodomain-like domain; Region: HTH_23; pfam13384 1283330009933 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330009934 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330009935 Winged helix-turn helix; Region: HTH_33; pfam13592 1283330009936 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330009937 Transposase domain (DUF772); Region: DUF772; pfam05598 1283330009938 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283330009939 DDE superfamily endonuclease; Region: DDE_4; cl17710 1283330009940 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1283330009941 Integrase core domain; Region: rve; pfam00665 1283330009942 Integrase core domain; Region: rve_3; pfam13683 1283330009943 transposase/IS protein; Provisional; Region: PRK09183 1283330009944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330009945 Walker A motif; other site 1283330009946 ATP binding site [chemical binding]; other site 1283330009947 Walker B motif; other site 1283330009948 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1283330009949 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1283330009950 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 1283330009951 DNA binding site [nucleotide binding] 1283330009952 DNA-binding interface [nucleotide binding]; DNA binding site 1283330009953 domain linker motif; other site 1283330009954 Integrase core domain; Region: rve; pfam00665 1283330009955 Integrase core domain; Region: rve_3; cl15866 1283330009956 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1283330009957 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 1283330009958 Fic family protein [Function unknown]; Region: COG3177 1283330009959 Fic/DOC family; Region: Fic; pfam02661 1283330009960 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 1283330009961 Putative helicase; Region: TraI_2; pfam07514 1283330009962 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 1283330009963 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1283330009964 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1283330009965 active site 1283330009966 catalytic residues [active] 1283330009967 DNA binding site [nucleotide binding] 1283330009968 Int/Topo IB signature motif; other site 1283330009969 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1283330009970 Ligand Binding Site [chemical binding]; other site 1283330009971 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 1283330009972 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283330009973 FeS/SAM binding site; other site 1283330009974 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1283330009975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283330009976 binding surface 1283330009977 TPR motif; other site 1283330009978 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1283330009979 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283330009980 ligand binding site [chemical binding]; other site 1283330009981 translocation protein TolB; Provisional; Region: tolB; PRK00178 1283330009982 TolB amino-terminal domain; Region: TolB_N; pfam04052 1283330009983 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1283330009984 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1283330009985 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1283330009986 TolA protein; Region: tolA_full; TIGR02794 1283330009987 TolA protein; Region: tolA_full; TIGR02794 1283330009988 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1283330009989 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1283330009990 TolR protein; Region: tolR; TIGR02801 1283330009991 TolQ protein; Region: tolQ; TIGR02796 1283330009992 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1283330009993 active site 1283330009994 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1283330009995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330009996 Walker A motif; other site 1283330009997 ATP binding site [chemical binding]; other site 1283330009998 Walker B motif; other site 1283330009999 arginine finger; other site 1283330010000 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1283330010001 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1283330010002 RuvA N terminal domain; Region: RuvA_N; pfam01330 1283330010003 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1283330010004 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1283330010005 active site 1283330010006 putative DNA-binding cleft [nucleotide binding]; other site 1283330010007 dimer interface [polypeptide binding]; other site 1283330010008 hypothetical protein; Validated; Region: PRK00110 1283330010009 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1283330010010 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1283330010011 dimer interface [polypeptide binding]; other site 1283330010012 anticodon binding site; other site 1283330010013 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1283330010014 homodimer interface [polypeptide binding]; other site 1283330010015 motif 1; other site 1283330010016 active site 1283330010017 motif 2; other site 1283330010018 GAD domain; Region: GAD; pfam02938 1283330010019 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1283330010020 active site 1283330010021 motif 3; other site 1283330010022 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1283330010023 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1283330010024 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1283330010025 dimer interface [polypeptide binding]; other site 1283330010026 motif 1; other site 1283330010027 active site 1283330010028 motif 2; other site 1283330010029 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1283330010030 putative deacylase active site [active] 1283330010031 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1283330010032 active site 1283330010033 motif 3; other site 1283330010034 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1283330010035 anticodon binding site; other site 1283330010036 acylphosphatase; Provisional; Region: PRK14442 1283330010037 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1283330010038 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1283330010039 catalytic residues [active] 1283330010040 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1283330010041 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 1283330010042 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1283330010043 ArsC family; Region: ArsC; pfam03960 1283330010044 catalytic residues [active] 1283330010045 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1283330010046 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1283330010047 Predicted membrane protein (DUF2069); Region: DUF2069; cl01299 1283330010048 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1283330010049 DNA replication initiation factor; Validated; Region: PRK05642 1283330010050 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1283330010051 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1283330010052 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1283330010053 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1283330010054 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1283330010055 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1283330010056 dimerization interface [polypeptide binding]; other site 1283330010057 putative ATP binding site [chemical binding]; other site 1283330010058 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1283330010059 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1283330010060 active site 1283330010061 substrate binding site [chemical binding]; other site 1283330010062 cosubstrate binding site; other site 1283330010063 catalytic site [active] 1283330010064 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1283330010065 RelB antitoxin; Region: RelB; cl01171 1283330010066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 1283330010067 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831 1283330010068 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1283330010069 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1283330010070 homodimer interface [polypeptide binding]; other site 1283330010071 metal binding site [ion binding]; metal-binding site 1283330010072 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1283330010073 homodimer interface [polypeptide binding]; other site 1283330010074 active site 1283330010075 putative chemical substrate binding site [chemical binding]; other site 1283330010076 metal binding site [ion binding]; metal-binding site 1283330010077 Protein of unknown function (DUF3325); Region: DUF3325; pfam11804 1283330010078 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1283330010079 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1283330010080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330010081 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 1283330010082 outer membrane receptor FepA; Provisional; Region: PRK13528 1283330010083 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330010084 N-terminal plug; other site 1283330010085 ligand-binding site [chemical binding]; other site 1283330010086 outer membrane receptor FepA; Provisional; Region: PRK13524 1283330010087 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330010088 N-terminal plug; other site 1283330010089 ligand-binding site [chemical binding]; other site 1283330010090 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283330010091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283330010092 dimerization interface [polypeptide binding]; other site 1283330010093 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1283330010094 dimer interface [polypeptide binding]; other site 1283330010095 phosphorylation site [posttranslational modification] 1283330010096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330010097 ATP binding site [chemical binding]; other site 1283330010098 Mg2+ binding site [ion binding]; other site 1283330010099 G-X-G motif; other site 1283330010100 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1283330010101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330010102 active site 1283330010103 phosphorylation site [posttranslational modification] 1283330010104 intermolecular recognition site; other site 1283330010105 dimerization interface [polypeptide binding]; other site 1283330010106 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283330010107 DNA binding site [nucleotide binding] 1283330010108 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1283330010109 HD domain; Region: HD_4; pfam13328 1283330010110 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1283330010111 synthetase active site [active] 1283330010112 NTP binding site [chemical binding]; other site 1283330010113 metal binding site [ion binding]; metal-binding site 1283330010114 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1283330010115 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1283330010116 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1283330010117 TRAM domain; Region: TRAM; pfam01938 1283330010118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330010119 S-adenosylmethionine binding site [chemical binding]; other site 1283330010120 cysteine synthase B; Region: cysM; TIGR01138 1283330010121 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1283330010122 dimer interface [polypeptide binding]; other site 1283330010123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330010124 catalytic residue [active] 1283330010125 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1283330010126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283330010127 dimerization interface [polypeptide binding]; other site 1283330010128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330010129 dimer interface [polypeptide binding]; other site 1283330010130 phosphorylation site [posttranslational modification] 1283330010131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330010132 ATP binding site [chemical binding]; other site 1283330010133 Mg2+ binding site [ion binding]; other site 1283330010134 G-X-G motif; other site 1283330010135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330010136 active site 1283330010137 phosphorylation site [posttranslational modification] 1283330010138 intermolecular recognition site; other site 1283330010139 dimerization interface [polypeptide binding]; other site 1283330010140 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1283330010141 putative binding surface; other site 1283330010142 active site 1283330010143 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1283330010144 active site 1283330010145 DNA polymerase IV; Validated; Region: PRK02406 1283330010146 DNA binding site [nucleotide binding] 1283330010147 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1283330010148 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1283330010149 catalytic residues [active] 1283330010150 catalytic nucleophile [active] 1283330010151 Recombinase; Region: Recombinase; pfam07508 1283330010152 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1283330010153 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 1283330010154 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1283330010155 active site 1283330010156 metal binding site [ion binding]; metal-binding site 1283330010157 interdomain interaction site; other site 1283330010158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330010159 Walker A/P-loop; other site 1283330010160 ATP binding site [chemical binding]; other site 1283330010161 Q-loop/lid; other site 1283330010162 AntA/AntB antirepressor; Region: AntA; pfam08346 1283330010163 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 1283330010164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1283330010165 non-specific DNA binding site [nucleotide binding]; other site 1283330010166 salt bridge; other site 1283330010167 sequence-specific DNA binding site [nucleotide binding]; other site 1283330010168 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1283330010169 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1283330010170 Domain of unknown function (DUF955); Region: DUF955; cl01076 1283330010171 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1283330010172 P2 prophage; not known if it is functional in this host 1283330010173 tail protein; Provisional; Region: D; PHA02561 1283330010174 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1283330010175 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1283330010176 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1283330010177 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1283330010178 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1283330010179 major tail tube protein; Provisional; Region: FII; PHA02600 1283330010180 major tail sheath protein; Provisional; Region: FI; PHA02560 1283330010181 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1283330010182 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 1283330010183 Baseplate J-like protein; Region: Baseplate_J; cl01294 1283330010184 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1283330010185 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1283330010186 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1283330010187 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 1283330010188 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1283330010189 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1283330010190 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1283330010191 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 1283330010192 Phage holin family (Lysis protein S); Region: Phage_holin_3; pfam05106 1283330010193 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 1283330010194 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1283330010195 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1283330010196 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1283330010197 capsid protein; Provisional; Region: N; PHA02538 1283330010198 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 1283330010199 terminase ATPase subunit; Provisional; Region: P; PHA02535 1283330010200 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1283330010201 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 1283330010202 portal vertex protein; Provisional; Region: Q; PHA02536 1283330010203 Phage portal protein; Region: Phage_portal; pfam04860 1283330010204 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1283330010205 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1283330010206 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1283330010207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283330010208 FeS/SAM binding site; other site 1283330010209 TRAM domain; Region: TRAM; cl01282 1283330010210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1283330010211 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1283330010212 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1283330010213 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1283330010214 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1283330010215 conserved cys residue [active] 1283330010216 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1283330010217 putative active site [active] 1283330010218 catalytic site [active] 1283330010219 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1283330010220 PLD-like domain; Region: PLDc_2; pfam13091 1283330010221 putative active site [active] 1283330010222 catalytic site [active] 1283330010223 Beta-lactamase; Region: Beta-lactamase; pfam00144 1283330010224 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1283330010225 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1283330010226 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1283330010227 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1283330010228 putative acyl-acceptor binding pocket; other site 1283330010229 Protein of unknown function, DUF479; Region: DUF479; cl01203 1283330010230 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283330010231 dimerization interface [polypeptide binding]; other site 1283330010232 putative DNA binding site [nucleotide binding]; other site 1283330010233 putative Zn2+ binding site [ion binding]; other site 1283330010234 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1283330010235 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1283330010236 FMN binding site [chemical binding]; other site 1283330010237 active site 1283330010238 substrate binding site [chemical binding]; other site 1283330010239 catalytic residue [active] 1283330010240 superoxide dismutase; Provisional; Region: PRK10543 1283330010241 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1283330010242 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1283330010243 biofilm formation regulator HmsP; Provisional; Region: PRK11829 1283330010244 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330010245 metal binding site [ion binding]; metal-binding site 1283330010246 active site 1283330010247 I-site; other site 1283330010248 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283330010249 Imelysin; Region: Peptidase_M75; cl09159 1283330010250 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1283330010251 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1283330010252 Imelysin; Region: Peptidase_M75; cl09159 1283330010253 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 1283330010254 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1283330010255 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1283330010256 Surface antigen; Region: Bac_surface_Ag; pfam01103 1283330010257 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1283330010258 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1283330010259 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1283330010260 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1283330010261 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283330010262 ligand binding site [chemical binding]; other site 1283330010263 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330010264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330010265 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283330010266 dimerization interface [polypeptide binding]; other site 1283330010267 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 1283330010268 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1283330010269 putative NAD(P) binding site [chemical binding]; other site 1283330010270 substrate binding site [chemical binding]; other site 1283330010271 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1283330010272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330010273 S-adenosylmethionine binding site [chemical binding]; other site 1283330010274 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1283330010275 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283330010276 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1283330010277 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330010278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330010279 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1283330010280 putative effector binding pocket; other site 1283330010281 putative dimerization interface [polypeptide binding]; other site 1283330010282 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283330010283 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283330010284 active site 1283330010285 catalytic tetrad [active] 1283330010286 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283330010287 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283330010288 active site 1283330010289 catalytic tetrad [active] 1283330010290 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1283330010291 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1283330010292 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1283330010293 active site 1283330010294 trimer interface [polypeptide binding]; other site 1283330010295 dimer interface [polypeptide binding]; other site 1283330010296 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1283330010297 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1283330010298 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1283330010299 shikimate binding site; other site 1283330010300 NAD(P) binding site [chemical binding]; other site 1283330010301 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283330010302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283330010303 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1283330010304 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1283330010305 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1283330010306 dimer interface [polypeptide binding]; other site 1283330010307 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1283330010308 active site 1283330010309 Fe binding site [ion binding]; other site 1283330010310 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330010311 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330010312 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283330010313 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283330010314 active site 1283330010315 catalytic tetrad [active] 1283330010316 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 1283330010317 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1283330010318 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 1283330010319 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1283330010320 tetramer interface [polypeptide binding]; other site 1283330010321 active site 1283330010322 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1283330010323 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283330010324 dimer interface [polypeptide binding]; other site 1283330010325 active site 1283330010326 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 1283330010327 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1283330010328 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1283330010329 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1283330010330 Bacterial transcriptional regulator; Region: IclR; pfam01614 1283330010331 Predicted ATPase [General function prediction only]; Region: COG1485 1283330010332 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 1283330010333 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 1283330010334 heterodimer interface [polypeptide binding]; other site 1283330010335 active site 1283330010336 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1283330010337 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1283330010338 active site 1283330010339 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1283330010340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330010341 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283330010342 dimerization interface [polypeptide binding]; other site 1283330010343 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1283330010344 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1283330010345 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1283330010346 putative active site [active] 1283330010347 putative substrate binding site [chemical binding]; other site 1283330010348 putative cosubstrate binding site; other site 1283330010349 catalytic site [active] 1283330010350 exonuclease I; Provisional; Region: sbcB; PRK11779 1283330010351 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1283330010352 active site 1283330010353 catalytic site [active] 1283330010354 substrate binding site [chemical binding]; other site 1283330010355 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1283330010356 RDD family; Region: RDD; pfam06271 1283330010357 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1283330010358 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1283330010359 MoxR-like ATPases [General function prediction only]; Region: COG0714 1283330010360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330010361 Walker A motif; other site 1283330010362 ATP binding site [chemical binding]; other site 1283330010363 Walker B motif; other site 1283330010364 arginine finger; other site 1283330010365 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1283330010366 Protein of unknown function DUF58; Region: DUF58; pfam01882 1283330010367 PilZ domain; Region: PilZ; pfam07238 1283330010368 universal stress protein UspE; Provisional; Region: PRK11175 1283330010369 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283330010370 Ligand Binding Site [chemical binding]; other site 1283330010371 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283330010372 Ligand Binding Site [chemical binding]; other site 1283330010373 pyruvate kinase; Provisional; Region: PRK05826 1283330010374 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1283330010375 domain interfaces; other site 1283330010376 active site 1283330010377 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330010378 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330010379 metal binding site [ion binding]; metal-binding site 1283330010380 active site 1283330010381 I-site; other site 1283330010382 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1283330010383 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1283330010384 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1283330010385 homodimer interaction site [polypeptide binding]; other site 1283330010386 cofactor binding site; other site 1283330010387 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1283330010388 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1283330010389 FAD binding pocket [chemical binding]; other site 1283330010390 FAD binding motif [chemical binding]; other site 1283330010391 phosphate binding motif [ion binding]; other site 1283330010392 beta-alpha-beta structure motif; other site 1283330010393 NAD binding pocket [chemical binding]; other site 1283330010394 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1283330010395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330010396 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1283330010397 putative dimerization interface [polypeptide binding]; other site 1283330010398 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1283330010399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330010400 active site 1283330010401 phosphorylation site [posttranslational modification] 1283330010402 intermolecular recognition site; other site 1283330010403 dimerization interface [polypeptide binding]; other site 1283330010404 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1283330010405 DNA binding residues [nucleotide binding] 1283330010406 dimerization interface [polypeptide binding]; other site 1283330010407 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1283330010408 Domain of unknown function (DUF4146); Region: DUF4146; pfam13652 1283330010409 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 1283330010410 XFP N-terminal domain; Region: XFP_N; pfam09364 1283330010411 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1283330010412 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1283330010413 Beta-Casp domain; Region: Beta-Casp; smart01027 1283330010414 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1283330010415 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1283330010416 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1283330010417 recombinase A; Provisional; Region: recA; PRK09354 1283330010418 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1283330010419 hexamer interface [polypeptide binding]; other site 1283330010420 Walker A motif; other site 1283330010421 ATP binding site [chemical binding]; other site 1283330010422 Walker B motif; other site 1283330010423 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1283330010424 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1283330010425 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1283330010426 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1283330010427 putative dimer interface [polypeptide binding]; other site 1283330010428 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1283330010429 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1283330010430 putative dimer interface [polypeptide binding]; other site 1283330010431 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1283330010432 MutS domain I; Region: MutS_I; pfam01624 1283330010433 MutS domain II; Region: MutS_II; pfam05188 1283330010434 MutS domain III; Region: MutS_III; pfam05192 1283330010435 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1283330010436 Walker A/P-loop; other site 1283330010437 ATP binding site [chemical binding]; other site 1283330010438 Q-loop/lid; other site 1283330010439 ABC transporter signature motif; other site 1283330010440 Walker B; other site 1283330010441 D-loop; other site 1283330010442 H-loop/switch region; other site 1283330010443 Ferredoxin [Energy production and conversion]; Region: COG1146 1283330010444 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1283330010445 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283330010446 dimer interface [polypeptide binding]; other site 1283330010447 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1283330010448 putative CheW interface [polypeptide binding]; other site 1283330010449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330010450 PAS fold; Region: PAS_3; pfam08447 1283330010451 putative active site [active] 1283330010452 heme pocket [chemical binding]; other site 1283330010453 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1283330010454 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 1283330010455 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1283330010456 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330010457 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1283330010458 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330010459 DNA binding residues [nucleotide binding] 1283330010460 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1283330010461 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1283330010462 Peptidase family M23; Region: Peptidase_M23; pfam01551 1283330010463 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1283330010464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330010465 S-adenosylmethionine binding site [chemical binding]; other site 1283330010466 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1283330010467 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1283330010468 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1283330010469 Permutation of conserved domain; other site 1283330010470 active site 1283330010471 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1283330010472 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1283330010473 homotrimer interaction site [polypeptide binding]; other site 1283330010474 zinc binding site [ion binding]; other site 1283330010475 CDP-binding sites; other site 1283330010476 S-formylglutathione hydrolase; Region: PLN02442 1283330010477 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1283330010478 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1283330010479 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1283330010480 substrate binding site [chemical binding]; other site 1283330010481 catalytic Zn binding site [ion binding]; other site 1283330010482 NAD binding site [chemical binding]; other site 1283330010483 structural Zn binding site [ion binding]; other site 1283330010484 dimer interface [polypeptide binding]; other site 1283330010485 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1283330010486 substrate binding site; other site 1283330010487 dimer interface; other site 1283330010488 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1283330010489 Septum formation initiator; Region: DivIC; cl17659 1283330010490 enolase; Provisional; Region: eno; PRK00077 1283330010491 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1283330010492 dimer interface [polypeptide binding]; other site 1283330010493 metal binding site [ion binding]; metal-binding site 1283330010494 substrate binding pocket [chemical binding]; other site 1283330010495 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1283330010496 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1283330010497 CTP synthetase; Validated; Region: pyrG; PRK05380 1283330010498 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1283330010499 Catalytic site [active] 1283330010500 active site 1283330010501 UTP binding site [chemical binding]; other site 1283330010502 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1283330010503 active site 1283330010504 putative oxyanion hole; other site 1283330010505 catalytic triad [active] 1283330010506 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1283330010507 TilS substrate binding domain; Region: TilS; pfam09179 1283330010508 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1283330010509 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1283330010510 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1283330010511 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1283330010512 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1283330010513 putative active site [active] 1283330010514 putative PHP Thumb interface [polypeptide binding]; other site 1283330010515 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1283330010516 generic binding surface II; other site 1283330010517 generic binding surface I; other site 1283330010518 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1283330010519 RNA/DNA hybrid binding site [nucleotide binding]; other site 1283330010520 active site 1283330010521 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1283330010522 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1283330010523 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1283330010524 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1283330010525 active site 1283330010526 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1283330010527 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1283330010528 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1283330010529 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1283330010530 trimer interface [polypeptide binding]; other site 1283330010531 active site 1283330010532 UDP-GlcNAc binding site [chemical binding]; other site 1283330010533 lipid binding site [chemical binding]; lipid-binding site 1283330010534 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 1283330010535 periplasmic chaperone; Provisional; Region: PRK10780 1283330010536 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1283330010537 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1283330010538 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1283330010539 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1283330010540 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1283330010541 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1283330010542 Surface antigen; Region: Bac_surface_Ag; pfam01103 1283330010543 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1283330010544 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1283330010545 active site 1283330010546 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1283330010547 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1283330010548 protein binding site [polypeptide binding]; other site 1283330010549 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1283330010550 putative substrate binding region [chemical binding]; other site 1283330010551 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1283330010552 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1283330010553 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1283330010554 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1283330010555 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1283330010556 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1283330010557 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1283330010558 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1283330010559 catalytic residue [active] 1283330010560 putative FPP diphosphate binding site; other site 1283330010561 putative FPP binding hydrophobic cleft; other site 1283330010562 dimer interface [polypeptide binding]; other site 1283330010563 putative IPP diphosphate binding site; other site 1283330010564 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1283330010565 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1283330010566 hinge region; other site 1283330010567 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1283330010568 putative nucleotide binding site [chemical binding]; other site 1283330010569 uridine monophosphate binding site [chemical binding]; other site 1283330010570 homohexameric interface [polypeptide binding]; other site 1283330010571 elongation factor Ts; Provisional; Region: tsf; PRK09377 1283330010572 UBA/TS-N domain; Region: UBA; pfam00627 1283330010573 Elongation factor TS; Region: EF_TS; pfam00889 1283330010574 Elongation factor TS; Region: EF_TS; pfam00889 1283330010575 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1283330010576 rRNA interaction site [nucleotide binding]; other site 1283330010577 S8 interaction site; other site 1283330010578 putative laminin-1 binding site; other site 1283330010579 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1283330010580 active site 1283330010581 PII uridylyl-transferase; Provisional; Region: glnD; PRK00275 1283330010582 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1283330010583 metal binding triad; other site 1283330010584 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1283330010585 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1283330010586 Zn2+ binding site [ion binding]; other site 1283330010587 Mg2+ binding site [ion binding]; other site 1283330010588 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1283330010589 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1283330010590 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1283330010591 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283330010592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330010593 homodimer interface [polypeptide binding]; other site 1283330010594 catalytic residue [active] 1283330010595 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1283330010596 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 1283330010597 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 1283330010598 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1283330010599 ArsC family; Region: ArsC; pfam03960 1283330010600 putative catalytic residues [active] 1283330010601 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536 1283330010602 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1283330010603 putative trimer interface [polypeptide binding]; other site 1283330010604 putative CoA binding site [chemical binding]; other site 1283330010605 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1283330010606 Aminotransferase class-V; Region: Aminotran_5; pfam00266 1283330010607 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283330010608 catalytic residue [active] 1283330010609 Fe-S metabolism associated domain; Region: SufE; cl00951 1283330010610 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1283330010611 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1283330010612 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1283330010613 putative ATP binding site [chemical binding]; other site 1283330010614 putative substrate interface [chemical binding]; other site 1283330010615 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1283330010616 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1283330010617 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 1283330010618 Ligand binding site; other site 1283330010619 DXD motif; other site 1283330010620 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1283330010621 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1283330010622 metal binding site [ion binding]; metal-binding site 1283330010623 dimer interface [polypeptide binding]; other site 1283330010624 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1283330010625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1283330010626 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1283330010627 DNA-binding site [nucleotide binding]; DNA binding site 1283330010628 RNA-binding motif; other site 1283330010629 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 1283330010630 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1283330010631 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1283330010632 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 1283330010633 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1283330010634 Walker A/P-loop; other site 1283330010635 ATP binding site [chemical binding]; other site 1283330010636 Q-loop/lid; other site 1283330010637 ABC transporter signature motif; other site 1283330010638 Walker B; other site 1283330010639 D-loop; other site 1283330010640 H-loop/switch region; other site 1283330010641 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 1283330010642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330010643 S-adenosylmethionine binding site [chemical binding]; other site 1283330010644 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1283330010645 Protein of unknown function DUF72; Region: DUF72; cl00777 1283330010646 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1283330010647 Glycoprotease family; Region: Peptidase_M22; pfam00814 1283330010648 adenylate kinase; Reviewed; Region: adk; PRK00279 1283330010649 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1283330010650 AMP-binding site [chemical binding]; other site 1283330010651 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1283330010652 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1283330010653 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1283330010654 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1283330010655 putative ADP-ribose binding site [chemical binding]; other site 1283330010656 putative active site [active] 1283330010657 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1283330010658 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1283330010659 Secretory lipase; Region: LIP; pfam03583 1283330010660 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1283330010661 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 1283330010662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1283330010663 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1283330010664 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1283330010665 dimer interface [polypeptide binding]; other site 1283330010666 putative anticodon binding site; other site 1283330010667 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1283330010668 motif 1; other site 1283330010669 active site 1283330010670 motif 2; other site 1283330010671 motif 3; other site 1283330010672 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1283330010673 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1283330010674 RF-1 domain; Region: RF-1; pfam00472 1283330010675 Protein of unknown function (DUF533); Region: DUF533; pfam04391 1283330010676 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1283330010677 putative metal binding site [ion binding]; other site 1283330010678 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1283330010679 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1283330010680 active site 1283330010681 FMN binding site [chemical binding]; other site 1283330010682 substrate binding site [chemical binding]; other site 1283330010683 homotetramer interface [polypeptide binding]; other site 1283330010684 catalytic residue [active] 1283330010685 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1283330010686 DHH family; Region: DHH; pfam01368 1283330010687 DHHA1 domain; Region: DHHA1; pfam02272 1283330010688 YaeQ protein; Region: YaeQ; pfam07152 1283330010689 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330010690 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330010691 metal binding site [ion binding]; metal-binding site 1283330010692 active site 1283330010693 I-site; other site 1283330010694 Protein of unknown function (DUF3509); Region: DUF3509; pfam12021 1283330010695 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1283330010696 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1283330010697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330010698 catalytic residue [active] 1283330010699 homoserine dehydrogenase; Provisional; Region: PRK06349 1283330010700 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1283330010701 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1283330010702 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1283330010703 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1283330010704 dimerization domain [polypeptide binding]; other site 1283330010705 dimer interface [polypeptide binding]; other site 1283330010706 catalytic residues [active] 1283330010707 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1283330010708 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1283330010709 active site 1283330010710 Int/Topo IB signature motif; other site 1283330010711 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1283330010712 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1283330010713 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1283330010714 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1283330010715 RimM N-terminal domain; Region: RimM; pfam01782 1283330010716 PRC-barrel domain; Region: PRC; pfam05239 1283330010717 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1283330010718 signal recognition particle protein; Provisional; Region: PRK10867 1283330010719 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1283330010720 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1283330010721 P loop; other site 1283330010722 GTP binding site [chemical binding]; other site 1283330010723 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1283330010724 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1283330010725 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1283330010726 Domain of unknown function DUF21; Region: DUF21; pfam01595 1283330010727 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1283330010728 Transporter associated domain; Region: CorC_HlyC; smart01091 1283330010729 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1283330010730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330010731 ATP-grasp domain; Region: ATP-grasp; pfam02222 1283330010732 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1283330010733 putative active site [active] 1283330010734 putative CoA binding site [chemical binding]; other site 1283330010735 nudix motif; other site 1283330010736 metal binding site [ion binding]; metal-binding site 1283330010737 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 1283330010738 nudix motif; other site 1283330010739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1283330010740 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1283330010741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1283330010742 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1283330010743 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1283330010744 dimerization interface [polypeptide binding]; other site 1283330010745 ATP binding site [chemical binding]; other site 1283330010746 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1283330010747 dimerization interface [polypeptide binding]; other site 1283330010748 ATP binding site [chemical binding]; other site 1283330010749 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1283330010750 putative active site [active] 1283330010751 catalytic triad [active] 1283330010752 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1283330010753 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330010754 substrate binding pocket [chemical binding]; other site 1283330010755 membrane-bound complex binding site; other site 1283330010756 hinge residues; other site 1283330010757 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1283330010758 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1283330010759 catalytic residue [active] 1283330010760 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1283330010761 nucleoside/Zn binding site; other site 1283330010762 dimer interface [polypeptide binding]; other site 1283330010763 catalytic motif [active] 1283330010764 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 1283330010765 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1283330010766 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1283330010767 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1283330010768 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1283330010769 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283330010770 catalytic loop [active] 1283330010771 iron binding site [ion binding]; other site 1283330010772 GMP synthase; Reviewed; Region: guaA; PRK00074 1283330010773 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1283330010774 AMP/PPi binding site [chemical binding]; other site 1283330010775 candidate oxyanion hole; other site 1283330010776 catalytic triad [active] 1283330010777 potential glutamine specificity residues [chemical binding]; other site 1283330010778 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1283330010779 ATP Binding subdomain [chemical binding]; other site 1283330010780 Ligand Binding sites [chemical binding]; other site 1283330010781 Dimerization subdomain; other site 1283330010782 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1283330010783 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1283330010784 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1283330010785 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1283330010786 active site 1283330010787 Family description; Region: UvrD_C_2; pfam13538 1283330010788 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1283330010789 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1283330010790 dimerization interface [polypeptide binding]; other site 1283330010791 NAD binding site [chemical binding]; other site 1283330010792 ligand binding site [chemical binding]; other site 1283330010793 catalytic site [active] 1283330010794 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1283330010795 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1283330010796 generic binding surface II; other site 1283330010797 generic binding surface I; other site 1283330010798 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1283330010799 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1283330010800 Peptidase family M23; Region: Peptidase_M23; pfam01551 1283330010801 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1283330010802 Coenzyme A binding pocket [chemical binding]; other site 1283330010803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1283330010804 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1283330010805 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1283330010806 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1283330010807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330010808 S-adenosylmethionine binding site [chemical binding]; other site 1283330010809 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1283330010810 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1283330010811 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1283330010812 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1283330010813 intersubunit interface [polypeptide binding]; other site 1283330010814 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283330010815 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330010816 N-terminal plug; other site 1283330010817 ligand-binding site [chemical binding]; other site 1283330010818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330010819 transcriptional activator TtdR; Provisional; Region: PRK09801 1283330010820 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283330010821 putative effector binding pocket; other site 1283330010822 dimerization interface [polypeptide binding]; other site 1283330010823 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1283330010824 hypothetical protein; Provisional; Region: PRK08204 1283330010825 active site 1283330010826 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1283330010827 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1283330010828 NAD(P) binding site [chemical binding]; other site 1283330010829 active site 1283330010830 hypothetical protein; Provisional; Region: PRK07877 1283330010831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330010832 putative transporter; Provisional; Region: PRK10504 1283330010833 putative substrate translocation pore; other site 1283330010834 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1283330010835 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1283330010836 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1283330010837 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1283330010838 DNA binding residues [nucleotide binding] 1283330010839 dimerization interface [polypeptide binding]; other site 1283330010840 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1283330010841 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1283330010842 dimer interface [polypeptide binding]; other site 1283330010843 active site 1283330010844 metal binding site [ion binding]; metal-binding site 1283330010845 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330010846 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 1283330010847 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1283330010848 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1283330010849 FAD binding pocket [chemical binding]; other site 1283330010850 FAD binding motif [chemical binding]; other site 1283330010851 phosphate binding motif [ion binding]; other site 1283330010852 beta-alpha-beta structure motif; other site 1283330010853 NAD binding pocket [chemical binding]; other site 1283330010854 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1283330010855 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1283330010856 Trp docking motif [polypeptide binding]; other site 1283330010857 putative active site [active] 1283330010858 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330010859 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1283330010860 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330010861 substrate binding pocket [chemical binding]; other site 1283330010862 membrane-bound complex binding site; other site 1283330010863 hinge residues; other site 1283330010864 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330010865 N-terminal plug; other site 1283330010866 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1283330010867 ligand-binding site [chemical binding]; other site 1283330010868 2-isopropylmalate synthase; Validated; Region: PRK03739 1283330010869 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1283330010870 active site 1283330010871 catalytic residues [active] 1283330010872 metal binding site [ion binding]; metal-binding site 1283330010873 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1283330010874 DNA-specific endonuclease I; Provisional; Region: PRK15137 1283330010875 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1283330010876 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 1283330010877 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1283330010878 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1283330010879 C-N hydrolase family amidase; Provisional; Region: PRK10438 1283330010880 putative active site [active] 1283330010881 catalytic triad [active] 1283330010882 dimer interface [polypeptide binding]; other site 1283330010883 multimer interface [polypeptide binding]; other site 1283330010884 methionine aminotransferase; Validated; Region: PRK09082 1283330010885 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283330010886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330010887 homodimer interface [polypeptide binding]; other site 1283330010888 catalytic residue [active] 1283330010889 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283330010890 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283330010891 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330010892 N-terminal plug; other site 1283330010893 ligand-binding site [chemical binding]; other site 1283330010894 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283330010895 FecR protein; Region: FecR; pfam04773 1283330010896 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1283330010897 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330010898 DNA binding residues [nucleotide binding] 1283330010899 GTP-binding protein Der; Reviewed; Region: PRK00093 1283330010900 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1283330010901 G1 box; other site 1283330010902 GTP/Mg2+ binding site [chemical binding]; other site 1283330010903 Switch I region; other site 1283330010904 G2 box; other site 1283330010905 Switch II region; other site 1283330010906 G3 box; other site 1283330010907 G4 box; other site 1283330010908 G5 box; other site 1283330010909 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1283330010910 G1 box; other site 1283330010911 GTP/Mg2+ binding site [chemical binding]; other site 1283330010912 Switch I region; other site 1283330010913 G2 box; other site 1283330010914 G3 box; other site 1283330010915 Switch II region; other site 1283330010916 G4 box; other site 1283330010917 G5 box; other site 1283330010918 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1283330010919 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1283330010920 Trp docking motif [polypeptide binding]; other site 1283330010921 active site 1283330010922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1283330010923 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1283330010924 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1283330010925 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1283330010926 dimer interface [polypeptide binding]; other site 1283330010927 motif 1; other site 1283330010928 active site 1283330010929 motif 2; other site 1283330010930 motif 3; other site 1283330010931 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1283330010932 anticodon binding site; other site 1283330010933 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1283330010934 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1283330010935 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1283330010936 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1283330010937 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330010938 non-specific DNA binding site [nucleotide binding]; other site 1283330010939 salt bridge; other site 1283330010940 sequence-specific DNA binding site [nucleotide binding]; other site 1283330010941 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1283330010942 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1283330010943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283330010944 binding surface 1283330010945 TPR motif; other site 1283330010946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283330010947 binding surface 1283330010948 TPR motif; other site 1283330010949 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1283330010950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283330010951 FeS/SAM binding site; other site 1283330010952 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1283330010953 active site 1283330010954 multimer interface [polypeptide binding]; other site 1283330010955 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 1283330010956 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1283330010957 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283330010958 catalytic loop [active] 1283330010959 iron binding site [ion binding]; other site 1283330010960 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1283330010961 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1283330010962 nucleotide binding site [chemical binding]; other site 1283330010963 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1283330010964 SBD interface [polypeptide binding]; other site 1283330010965 co-chaperone HscB; Provisional; Region: hscB; PRK00294 1283330010966 DnaJ domain; Region: DnaJ; pfam00226 1283330010967 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 1283330010968 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1283330010969 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1283330010970 trimerization site [polypeptide binding]; other site 1283330010971 active site 1283330010972 cysteine desulfurase; Provisional; Region: PRK14012 1283330010973 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1283330010974 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283330010975 catalytic residue [active] 1283330010976 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 1283330010977 Rrf2 family protein; Region: rrf2_super; TIGR00738 1283330010978 serine O-acetyltransferase; Region: cysE; TIGR01172 1283330010979 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1283330010980 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1283330010981 trimer interface [polypeptide binding]; other site 1283330010982 active site 1283330010983 substrate binding site [chemical binding]; other site 1283330010984 CoA binding site [chemical binding]; other site 1283330010985 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1283330010986 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1283330010987 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1283330010988 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1283330010989 active site 1283330010990 dimerization interface [polypeptide binding]; other site 1283330010991 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1283330010992 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1283330010993 Protein export membrane protein; Region: SecD_SecF; pfam02355 1283330010994 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1283330010995 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1283330010996 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1283330010997 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1283330010998 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1283330010999 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1283330011000 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1283330011001 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1283330011002 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1283330011003 integrase; Provisional; Region: PRK09692 1283330011004 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1283330011005 active site 1283330011006 Int/Topo IB signature motif; other site 1283330011007 putative transposase OrfB; Reviewed; Region: PHA02517 1283330011008 HTH-like domain; Region: HTH_21; pfam13276 1283330011009 Integrase core domain; Region: rve; pfam00665 1283330011010 Integrase core domain; Region: rve_3; pfam13683 1283330011011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283330011012 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283330011013 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283330011014 Transposase; Region: HTH_Tnp_1; cl17663 1283330011015 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1283330011016 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 1283330011017 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1283330011018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330011019 non-specific DNA binding site [nucleotide binding]; other site 1283330011020 salt bridge; other site 1283330011021 sequence-specific DNA binding site [nucleotide binding]; other site 1283330011022 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 1283330011023 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1283330011024 active site 1283330011025 metal binding site [ion binding]; metal-binding site 1283330011026 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1283330011027 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1283330011028 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1283330011029 DNA binding site [nucleotide binding] 1283330011030 active site 1283330011031 CreA protein; Region: CreA; pfam05981 1283330011032 gamma-glutamyl kinase; Provisional; Region: PRK05429 1283330011033 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1283330011034 nucleotide binding site [chemical binding]; other site 1283330011035 homotetrameric interface [polypeptide binding]; other site 1283330011036 putative phosphate binding site [ion binding]; other site 1283330011037 putative allosteric binding site; other site 1283330011038 PUA domain; Region: PUA; pfam01472 1283330011039 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1283330011040 GTP1/OBG; Region: GTP1_OBG; pfam01018 1283330011041 Obg GTPase; Region: Obg; cd01898 1283330011042 G1 box; other site 1283330011043 GTP/Mg2+ binding site [chemical binding]; other site 1283330011044 Switch I region; other site 1283330011045 G2 box; other site 1283330011046 G3 box; other site 1283330011047 Switch II region; other site 1283330011048 G4 box; other site 1283330011049 G5 box; other site 1283330011050 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1283330011051 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1283330011052 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1283330011053 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1283330011054 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1283330011055 substrate binding pocket [chemical binding]; other site 1283330011056 chain length determination region; other site 1283330011057 substrate-Mg2+ binding site; other site 1283330011058 catalytic residues [active] 1283330011059 aspartate-rich region 1; other site 1283330011060 active site lid residues [active] 1283330011061 aspartate-rich region 2; other site 1283330011062 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1283330011063 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1283330011064 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1283330011065 hypothetical protein; Provisional; Region: PRK05208 1283330011066 AAA domain; Region: AAA_32; pfam13654 1283330011067 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1283330011068 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1283330011069 Protein of unknown function (DUF3015); Region: DUF3015; pfam11220 1283330011070 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1283330011071 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283330011072 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330011073 N-terminal plug; other site 1283330011074 ligand-binding site [chemical binding]; other site 1283330011075 fec operon regulator FecR; Reviewed; Region: PRK09774 1283330011076 FecR protein; Region: FecR; pfam04773 1283330011077 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1283330011078 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330011079 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330011080 DNA binding residues [nucleotide binding] 1283330011081 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1283330011082 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283330011083 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283330011084 ABC transporter; Region: ABC_tran_2; pfam12848 1283330011085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283330011086 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1283330011087 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1283330011088 dimer interface [polypeptide binding]; other site 1283330011089 active site 1283330011090 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1283330011091 folate binding site [chemical binding]; other site 1283330011092 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1283330011093 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1283330011094 P-loop, Walker A motif; other site 1283330011095 Base recognition motif; other site 1283330011096 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1283330011097 Uncharacterized small protein [Function unknown]; Region: COG2879 1283330011098 carbon starvation protein A; Provisional; Region: PRK15015 1283330011099 Carbon starvation protein CstA; Region: CstA; pfam02554 1283330011100 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1283330011101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 1283330011102 Cache domain; Region: Cache_2; pfam08269 1283330011103 Histidine kinase; Region: HisKA_3; pfam07730 1283330011104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330011105 ATP binding site [chemical binding]; other site 1283330011106 Mg2+ binding site [ion binding]; other site 1283330011107 G-X-G motif; other site 1283330011108 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1283330011109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330011110 active site 1283330011111 phosphorylation site [posttranslational modification] 1283330011112 intermolecular recognition site; other site 1283330011113 dimerization interface [polypeptide binding]; other site 1283330011114 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1283330011115 DNA binding residues [nucleotide binding] 1283330011116 dimerization interface [polypeptide binding]; other site 1283330011117 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1283330011118 DNA repair protein RadA; Provisional; Region: PRK11823 1283330011119 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1283330011120 Walker A motif; other site 1283330011121 ATP binding site [chemical binding]; other site 1283330011122 Walker B motif; other site 1283330011123 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1283330011124 Protein of unknown function (DUF465); Region: DUF465; cl01070 1283330011125 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1283330011126 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1283330011127 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1283330011128 catalytic residues [active] 1283330011129 dimer interface [polypeptide binding]; other site 1283330011130 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1283330011131 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1283330011132 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1283330011133 propionate/acetate kinase; Provisional; Region: PRK12379 1283330011134 phosphate acetyltransferase; Reviewed; Region: PRK05632 1283330011135 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1283330011136 DRTGG domain; Region: DRTGG; pfam07085 1283330011137 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1283330011138 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1283330011139 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283330011140 ligand binding site [chemical binding]; other site 1283330011141 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1283330011142 Response regulator receiver domain; Region: Response_reg; pfam00072 1283330011143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330011144 active site 1283330011145 phosphorylation site [posttranslational modification] 1283330011146 intermolecular recognition site; other site 1283330011147 dimerization interface [polypeptide binding]; other site 1283330011148 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1283330011149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330011150 Staphylococcal nuclease homologues; Region: SNc; smart00318 1283330011151 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1283330011152 Catalytic site; other site 1283330011153 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1283330011154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283330011155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330011156 dimer interface [polypeptide binding]; other site 1283330011157 phosphorylation site [posttranslational modification] 1283330011158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330011159 ATP binding site [chemical binding]; other site 1283330011160 Mg2+ binding site [ion binding]; other site 1283330011161 G-X-G motif; other site 1283330011162 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1283330011163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330011164 active site 1283330011165 phosphorylation site [posttranslational modification] 1283330011166 intermolecular recognition site; other site 1283330011167 dimerization interface [polypeptide binding]; other site 1283330011168 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 1283330011169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1283330011170 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1283330011171 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1283330011172 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 1283330011173 glycerate dehydrogenase; Provisional; Region: PRK06487 1283330011174 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1283330011175 putative ligand binding site [chemical binding]; other site 1283330011176 putative NAD binding site [chemical binding]; other site 1283330011177 catalytic site [active] 1283330011178 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1283330011179 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1283330011180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330011181 S-adenosylmethionine binding site [chemical binding]; other site 1283330011182 yybP-ykoY; predicted by Infernal 1283330011183 Predicted membrane protein [Function unknown]; Region: COG2119 1283330011184 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1283330011185 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1283330011186 Predicted membrane protein [Function unknown]; Region: COG2119 1283330011187 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1283330011188 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1283330011189 Peptidase family M48; Region: Peptidase_M48; pfam01435 1283330011190 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1283330011191 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1283330011192 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1283330011193 putative acyl-acceptor binding pocket; other site 1283330011194 malate:quinone oxidoreductase; Reviewed; Region: PRK13339 1283330011195 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1283330011196 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283330011197 active site 1283330011198 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283330011199 active site 1283330011200 ferrochelatase; Reviewed; Region: hemH; PRK00035 1283330011201 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1283330011202 C-terminal domain interface [polypeptide binding]; other site 1283330011203 active site 1283330011204 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1283330011205 active site 1283330011206 N-terminal domain interface [polypeptide binding]; other site 1283330011207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330011208 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1283330011209 NAD(P) binding site [chemical binding]; other site 1283330011210 active site 1283330011211 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1283330011212 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1283330011213 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1283330011214 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1283330011215 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1283330011216 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1283330011217 DNA binding residues [nucleotide binding] 1283330011218 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1283330011219 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1283330011220 DNA photolyase; Region: DNA_photolyase; pfam00875 1283330011221 glutamate racemase; Provisional; Region: PRK00865 1283330011222 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1283330011223 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1283330011224 ATP binding site [chemical binding]; other site 1283330011225 substrate interface [chemical binding]; other site 1283330011226 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1283330011227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330011228 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1283330011229 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1283330011230 RF-1 domain; Region: RF-1; pfam00472 1283330011231 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1283330011232 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1283330011233 tRNA; other site 1283330011234 putative tRNA binding site [nucleotide binding]; other site 1283330011235 putative NADP binding site [chemical binding]; other site 1283330011236 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1283330011237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283330011238 TPR motif; other site 1283330011239 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1283330011240 binding surface 1283330011241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283330011242 binding surface 1283330011243 TPR motif; other site 1283330011244 TPR repeat; Region: TPR_11; pfam13414 1283330011245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283330011246 binding surface 1283330011247 TPR motif; other site 1283330011248 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1283330011249 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1283330011250 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1283330011251 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1283330011252 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1283330011253 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283330011254 active site 1283330011255 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1283330011256 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1283330011257 5S rRNA interface [nucleotide binding]; other site 1283330011258 CTC domain interface [polypeptide binding]; other site 1283330011259 L16 interface [polypeptide binding]; other site 1283330011260 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1283330011261 putative active site [active] 1283330011262 catalytic residue [active] 1283330011263 GTP-binding protein YchF; Reviewed; Region: PRK09601 1283330011264 YchF GTPase; Region: YchF; cd01900 1283330011265 G1 box; other site 1283330011266 GTP/Mg2+ binding site [chemical binding]; other site 1283330011267 Switch I region; other site 1283330011268 G2 box; other site 1283330011269 Switch II region; other site 1283330011270 G3 box; other site 1283330011271 G4 box; other site 1283330011272 G5 box; other site 1283330011273 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1283330011274 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330011275 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330011276 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283330011277 dimerization interface [polypeptide binding]; other site 1283330011278 putative DNA binding site [nucleotide binding]; other site 1283330011279 putative Zn2+ binding site [ion binding]; other site 1283330011280 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1283330011281 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1283330011282 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1283330011283 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1283330011284 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1283330011285 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1283330011286 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1283330011287 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283330011288 FeS/SAM binding site; other site 1283330011289 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1283330011290 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 1283330011291 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1283330011292 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1283330011293 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1283330011294 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1283330011295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330011296 Walker A motif; other site 1283330011297 ATP binding site [chemical binding]; other site 1283330011298 Walker B motif; other site 1283330011299 arginine finger; other site 1283330011300 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330011301 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1283330011302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330011303 NAD(P) binding site [chemical binding]; other site 1283330011304 active site 1283330011305 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 1283330011306 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1283330011307 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1283330011308 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1283330011309 tetramer interface [polypeptide binding]; other site 1283330011310 TPP-binding site [chemical binding]; other site 1283330011311 heterodimer interface [polypeptide binding]; other site 1283330011312 phosphorylation loop region [posttranslational modification] 1283330011313 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1283330011314 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1283330011315 alpha subunit interface [polypeptide binding]; other site 1283330011316 TPP binding site [chemical binding]; other site 1283330011317 heterodimer interface [polypeptide binding]; other site 1283330011318 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1283330011319 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 1283330011320 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1283330011321 E3 interaction surface; other site 1283330011322 lipoyl attachment site [posttranslational modification]; other site 1283330011323 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1283330011324 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1283330011325 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1283330011326 putative NAD(P) binding site [chemical binding]; other site 1283330011327 catalytic Zn binding site [ion binding]; other site 1283330011328 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1283330011329 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1283330011330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330011331 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283330011332 putative substrate translocation pore; other site 1283330011333 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1283330011334 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1283330011335 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1283330011336 FeS/SAM binding site; other site 1283330011337 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330011338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330011339 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1283330011340 dimerization interface [polypeptide binding]; other site 1283330011341 DDE superfamily endonuclease; Region: DDE_5; cl17874 1283330011342 putative transposase OrfB; Reviewed; Region: PHA02517 1283330011343 HTH-like domain; Region: HTH_21; pfam13276 1283330011344 Integrase core domain; Region: rve; pfam00665 1283330011345 Integrase core domain; Region: rve_3; pfam13683 1283330011346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283330011347 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283330011348 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283330011349 Transposase; Region: HTH_Tnp_1; cl17663 1283330011350 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1283330011351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330011352 putative substrate translocation pore; other site 1283330011353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330011354 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283330011355 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330011356 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283330011357 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1283330011358 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1283330011359 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1283330011360 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1283330011361 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1283330011362 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1283330011363 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1283330011364 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1283330011365 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1283330011366 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1283330011367 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1283330011368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330011369 sequence-specific DNA binding site [nucleotide binding]; other site 1283330011370 salt bridge; other site 1283330011371 Fic family protein [Function unknown]; Region: COG3177 1283330011372 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 1283330011373 Fic/DOC family; Region: Fic; pfam02661 1283330011374 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1283330011375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330011376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330011377 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1283330011378 putative effector binding pocket; other site 1283330011379 putative dimerization interface [polypeptide binding]; other site 1283330011380 Benzoate membrane transport protein; Region: BenE; pfam03594 1283330011381 benzoate transporter; Region: benE; TIGR00843 1283330011382 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330011383 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1283330011384 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283330011385 catalytic loop [active] 1283330011386 iron binding site [ion binding]; other site 1283330011387 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1283330011388 FAD binding pocket [chemical binding]; other site 1283330011389 FAD binding motif [chemical binding]; other site 1283330011390 phosphate binding motif [ion binding]; other site 1283330011391 beta-alpha-beta structure motif; other site 1283330011392 NAD binding pocket [chemical binding]; other site 1283330011393 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1283330011394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330011395 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1283330011396 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1283330011397 active site 1283330011398 catalytic residues [active] 1283330011399 metal binding site [ion binding]; metal-binding site 1283330011400 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1283330011401 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1283330011402 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1283330011403 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1283330011404 feruloyl-CoA synthase; Reviewed; Region: PRK08180 1283330011405 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 1283330011406 acyl-activating enzyme (AAE) consensus motif; other site 1283330011407 putative AMP binding site [chemical binding]; other site 1283330011408 putative active site [active] 1283330011409 putative CoA binding site [chemical binding]; other site 1283330011410 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1283330011411 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1283330011412 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1283330011413 FMN binding site [chemical binding]; other site 1283330011414 substrate binding site [chemical binding]; other site 1283330011415 putative catalytic residue [active] 1283330011416 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1283330011417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330011418 NAD(P) binding site [chemical binding]; other site 1283330011419 active site 1283330011420 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1283330011421 inter-subunit interface; other site 1283330011422 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1283330011423 iron-sulfur cluster [ion binding]; other site 1283330011424 [2Fe-2S] cluster binding site [ion binding]; other site 1283330011425 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1283330011426 beta subunit interface [polypeptide binding]; other site 1283330011427 alpha subunit interface [polypeptide binding]; other site 1283330011428 active site 1283330011429 substrate binding site [chemical binding]; other site 1283330011430 Fe binding site [ion binding]; other site 1283330011431 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1283330011432 [2Fe-2S] cluster binding site [ion binding]; other site 1283330011433 PhnC is a Class III Extradiol ring-cleavage dioxygenase involved in the polycyclic aromatic hydrocarbon (PAH) catabolic pathway; Region: PhnC_Bs_like; cd07368 1283330011434 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1283330011435 putative active site [active] 1283330011436 Fe(II) binding site [ion binding]; other site 1283330011437 putative dimer interface [polypeptide binding]; other site 1283330011438 putative tetramer interface [polypeptide binding]; other site 1283330011439 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cd07321 1283330011440 dimer interface [polypeptide binding]; other site 1283330011441 tetramer interface [polypeptide binding]; other site 1283330011442 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1283330011443 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1283330011444 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283330011445 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330011446 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330011447 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330011448 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330011449 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330011450 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330011451 Transmembrane secretion effector; Region: MFS_3; pfam05977 1283330011452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330011453 putative substrate translocation pore; other site 1283330011454 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1283330011455 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1283330011456 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1283330011457 active site 1283330011458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1283330011459 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1283330011460 Isochorismatase family; Region: Isochorismatase; pfam00857 1283330011461 catalytic triad [active] 1283330011462 dimer interface [polypeptide binding]; other site 1283330011463 conserved cis-peptide bond; other site 1283330011464 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1283330011465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330011466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330011467 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1283330011468 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1283330011469 Probable transposase; Region: OrfB_IS605; pfam01385 1283330011470 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1283330011471 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1283330011472 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1283330011473 active site 1283330011474 homotetramer interface [polypeptide binding]; other site 1283330011475 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1283330011476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330011477 active site 1283330011478 motif I; other site 1283330011479 motif II; other site 1283330011480 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1283330011481 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1283330011482 2-isopropylmalate synthase; Validated; Region: PRK00915 1283330011483 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1283330011484 active site 1283330011485 catalytic residues [active] 1283330011486 metal binding site [ion binding]; metal-binding site 1283330011487 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1283330011488 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1283330011489 mce related protein; Region: MCE; pfam02470 1283330011490 mce related protein; Region: MCE; pfam02470 1283330011491 mce related protein; Region: MCE; pfam02470 1283330011492 mce related protein; Region: MCE; pfam02470 1283330011493 mce related protein; Region: MCE; pfam02470 1283330011494 mce related protein; Region: MCE; pfam02470 1283330011495 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1283330011496 Paraquat-inducible protein A; Region: PqiA; pfam04403 1283330011497 Paraquat-inducible protein A; Region: PqiA; pfam04403 1283330011498 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1283330011499 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1283330011500 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1283330011501 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1283330011502 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1283330011503 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1283330011504 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1283330011505 putative valine binding site [chemical binding]; other site 1283330011506 dimer interface [polypeptide binding]; other site 1283330011507 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1283330011508 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06466 1283330011509 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1283330011510 PYR/PP interface [polypeptide binding]; other site 1283330011511 dimer interface [polypeptide binding]; other site 1283330011512 TPP binding site [chemical binding]; other site 1283330011513 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1283330011514 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1283330011515 TPP-binding site [chemical binding]; other site 1283330011516 dimer interface [polypeptide binding]; other site 1283330011517 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1283330011518 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 1283330011519 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 1283330011520 Transglycosylase; Region: Transgly; pfam00912 1283330011521 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1283330011522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1283330011523 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1283330011524 AAA domain; Region: AAA_33; pfam13671 1283330011525 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1283330011526 active site 1283330011527 Protein of unknown function, DUF399; Region: DUF399; cl01139 1283330011528 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1283330011529 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1283330011530 Walker A/P-loop; other site 1283330011531 ATP binding site [chemical binding]; other site 1283330011532 Q-loop/lid; other site 1283330011533 ABC transporter signature motif; other site 1283330011534 Walker B; other site 1283330011535 D-loop; other site 1283330011536 H-loop/switch region; other site 1283330011537 FecCD transport family; Region: FecCD; pfam01032 1283330011538 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1283330011539 iron-sulfur cluster [ion binding]; other site 1283330011540 [2Fe-2S] cluster binding site [ion binding]; other site 1283330011541 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1283330011542 hypothetical protein; Provisional; Region: PRK08960 1283330011543 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283330011544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330011545 homodimer interface [polypeptide binding]; other site 1283330011546 catalytic residue [active] 1283330011547 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1283330011548 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 1283330011549 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1283330011550 active site 1283330011551 HIGH motif; other site 1283330011552 nucleotide binding site [chemical binding]; other site 1283330011553 active site 1283330011554 KMSKS motif; other site 1283330011555 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1283330011556 Na binding site [ion binding]; other site 1283330011557 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1283330011558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330011559 putative active site [active] 1283330011560 heme pocket [chemical binding]; other site 1283330011561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330011562 dimer interface [polypeptide binding]; other site 1283330011563 phosphorylation site [posttranslational modification] 1283330011564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330011565 ATP binding site [chemical binding]; other site 1283330011566 Mg2+ binding site [ion binding]; other site 1283330011567 G-X-G motif; other site 1283330011568 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1283330011569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330011570 active site 1283330011571 phosphorylation site [posttranslational modification] 1283330011572 intermolecular recognition site; other site 1283330011573 dimerization interface [polypeptide binding]; other site 1283330011574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330011575 Walker A motif; other site 1283330011576 ATP binding site [chemical binding]; other site 1283330011577 Walker B motif; other site 1283330011578 arginine finger; other site 1283330011579 poly(A) polymerase; Region: pcnB; TIGR01942 1283330011580 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1283330011581 active site 1283330011582 NTP binding site [chemical binding]; other site 1283330011583 metal binding triad [ion binding]; metal-binding site 1283330011584 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1283330011585 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1283330011586 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1283330011587 catalytic center binding site [active] 1283330011588 ATP binding site [chemical binding]; other site 1283330011589 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1283330011590 oligomerization interface [polypeptide binding]; other site 1283330011591 active site 1283330011592 metal binding site [ion binding]; metal-binding site 1283330011593 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1283330011594 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1283330011595 active site 1283330011596 ATP-binding site [chemical binding]; other site 1283330011597 pantoate-binding site; other site 1283330011598 HXXH motif; other site 1283330011599 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1283330011600 tetramerization interface [polypeptide binding]; other site 1283330011601 active site 1283330011602 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1283330011603 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1283330011604 active site 1283330011605 dimer interface [polypeptide binding]; other site 1283330011606 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1283330011607 dimer interface [polypeptide binding]; other site 1283330011608 active site 1283330011609 acetyl-CoA synthetase; Provisional; Region: PRK00174 1283330011610 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1283330011611 active site 1283330011612 CoA binding site [chemical binding]; other site 1283330011613 acyl-activating enzyme (AAE) consensus motif; other site 1283330011614 AMP binding site [chemical binding]; other site 1283330011615 acetate binding site [chemical binding]; other site 1283330011616 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1283330011617 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1283330011618 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1283330011619 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1283330011620 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 1283330011621 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1283330011622 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1283330011623 RNase E interface [polypeptide binding]; other site 1283330011624 trimer interface [polypeptide binding]; other site 1283330011625 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1283330011626 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1283330011627 RNase E interface [polypeptide binding]; other site 1283330011628 trimer interface [polypeptide binding]; other site 1283330011629 active site 1283330011630 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1283330011631 putative nucleic acid binding region [nucleotide binding]; other site 1283330011632 G-X-X-G motif; other site 1283330011633 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1283330011634 RNA binding site [nucleotide binding]; other site 1283330011635 domain interface; other site 1283330011636 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1283330011637 16S/18S rRNA binding site [nucleotide binding]; other site 1283330011638 S13e-L30e interaction site [polypeptide binding]; other site 1283330011639 25S rRNA binding site [nucleotide binding]; other site 1283330011640 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1283330011641 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1283330011642 RNA binding site [nucleotide binding]; other site 1283330011643 active site 1283330011644 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1283330011645 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1283330011646 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1283330011647 translation initiation factor IF-2; Region: IF-2; TIGR00487 1283330011648 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1283330011649 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1283330011650 G1 box; other site 1283330011651 putative GEF interaction site [polypeptide binding]; other site 1283330011652 GTP/Mg2+ binding site [chemical binding]; other site 1283330011653 Switch I region; other site 1283330011654 G2 box; other site 1283330011655 G3 box; other site 1283330011656 Switch II region; other site 1283330011657 G4 box; other site 1283330011658 G5 box; other site 1283330011659 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1283330011660 Translation-initiation factor 2; Region: IF-2; pfam11987 1283330011661 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1283330011662 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1283330011663 NusA N-terminal domain; Region: NusA_N; pfam08529 1283330011664 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1283330011665 RNA binding site [nucleotide binding]; other site 1283330011666 homodimer interface [polypeptide binding]; other site 1283330011667 NusA-like KH domain; Region: KH_5; pfam13184 1283330011668 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1283330011669 G-X-X-G motif; other site 1283330011670 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1283330011671 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1283330011672 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1283330011673 Sm and related proteins; Region: Sm_like; cl00259 1283330011674 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1283330011675 putative oligomer interface [polypeptide binding]; other site 1283330011676 putative RNA binding site [nucleotide binding]; other site 1283330011677 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1283330011678 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1283330011679 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1283330011680 active site 1283330011681 substrate binding site [chemical binding]; other site 1283330011682 metal binding site [ion binding]; metal-binding site 1283330011683 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1283330011684 dihydropteroate synthase; Region: DHPS; TIGR01496 1283330011685 substrate binding pocket [chemical binding]; other site 1283330011686 dimer interface [polypeptide binding]; other site 1283330011687 inhibitor binding site; inhibition site 1283330011688 FtsH Extracellular; Region: FtsH_ext; pfam06480 1283330011689 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1283330011690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330011691 Walker A motif; other site 1283330011692 ATP binding site [chemical binding]; other site 1283330011693 Walker B motif; other site 1283330011694 arginine finger; other site 1283330011695 Peptidase family M41; Region: Peptidase_M41; pfam01434 1283330011696 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1283330011697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330011698 S-adenosylmethionine binding site [chemical binding]; other site 1283330011699 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1283330011700 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1283330011701 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1283330011702 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1283330011703 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1283330011704 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1283330011705 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1283330011706 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1283330011707 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1283330011708 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1283330011709 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1283330011710 IMP binding site; other site 1283330011711 dimer interface [polypeptide binding]; other site 1283330011712 interdomain contacts; other site 1283330011713 partial ornithine binding site; other site 1283330011714 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1283330011715 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1283330011716 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1283330011717 catalytic site [active] 1283330011718 subunit interface [polypeptide binding]; other site 1283330011719 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1283330011720 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1283330011721 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1283330011722 chaperone protein DnaJ; Provisional; Region: PRK10767 1283330011723 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1283330011724 HSP70 interaction site [polypeptide binding]; other site 1283330011725 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1283330011726 substrate binding site [polypeptide binding]; other site 1283330011727 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1283330011728 Zn binding sites [ion binding]; other site 1283330011729 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1283330011730 dimer interface [polypeptide binding]; other site 1283330011731 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1283330011732 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1283330011733 nucleotide binding site [chemical binding]; other site 1283330011734 NEF interaction site [polypeptide binding]; other site 1283330011735 SBD interface [polypeptide binding]; other site 1283330011736 GrpE; Region: GrpE; pfam01025 1283330011737 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1283330011738 dimer interface [polypeptide binding]; other site 1283330011739 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1283330011740 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1283330011741 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1283330011742 Walker A/P-loop; other site 1283330011743 ATP binding site [chemical binding]; other site 1283330011744 Q-loop/lid; other site 1283330011745 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1283330011746 ABC transporter signature motif; other site 1283330011747 Walker B; other site 1283330011748 D-loop; other site 1283330011749 H-loop/switch region; other site 1283330011750 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1283330011751 metal binding site 2 [ion binding]; metal-binding site 1283330011752 putative DNA binding helix; other site 1283330011753 metal binding site 1 [ion binding]; metal-binding site 1283330011754 dimer interface [polypeptide binding]; other site 1283330011755 structural Zn2+ binding site [ion binding]; other site 1283330011756 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1283330011757 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1283330011758 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1283330011759 RnfH family Ubiquitin; Region: Ub-RnfH; cl17382 1283330011760 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1283330011761 putative coenzyme Q binding site [chemical binding]; other site 1283330011762 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1283330011763 SmpB-tmRNA interface; other site 1283330011764 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 1283330011765 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283330011766 DNA-binding site [nucleotide binding]; DNA binding site 1283330011767 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1283330011768 L-lactate permease; Region: Lactate_perm; cl00701 1283330011769 glycolate transporter; Provisional; Region: PRK09695 1283330011770 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1283330011771 Cysteine-rich domain; Region: CCG; pfam02754 1283330011772 Cysteine-rich domain; Region: CCG; pfam02754 1283330011773 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1283330011774 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1283330011775 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1283330011776 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1283330011777 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1283330011778 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1283330011779 FAD binding domain; Region: FAD_binding_4; pfam01565 1283330011780 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1283330011781 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1283330011782 Cysteine-rich domain; Region: CCG; pfam02754 1283330011783 Cache domain; Region: Cache_1; pfam02743 1283330011784 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283330011785 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1283330011786 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330011787 dimer interface [polypeptide binding]; other site 1283330011788 phosphorylation site [posttranslational modification] 1283330011789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330011790 ATP binding site [chemical binding]; other site 1283330011791 Mg2+ binding site [ion binding]; other site 1283330011792 G-X-G motif; other site 1283330011793 INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184 1283330011794 Int/Topo IB signature motif; other site 1283330011795 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1283330011796 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1283330011797 catalytic residues [active] 1283330011798 catalytic nucleophile [active] 1283330011799 Presynaptic Site I dimer interface [polypeptide binding]; other site 1283330011800 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1283330011801 Synaptic Flat tetramer interface [polypeptide binding]; other site 1283330011802 Synaptic Site I dimer interface [polypeptide binding]; other site 1283330011803 DNA binding site [nucleotide binding] 1283330011804 AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255 1283330011805 putative nucleotide binding site [chemical binding]; other site 1283330011806 putative substrate binding site [chemical binding]; other site 1283330011807 AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255 1283330011808 putative nucleotide binding site [chemical binding]; other site 1283330011809 putative substrate binding site [chemical binding]; other site 1283330011810 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1283330011811 PYR/PP interface [polypeptide binding]; other site 1283330011812 dimer interface [polypeptide binding]; other site 1283330011813 TPP binding site [chemical binding]; other site 1283330011814 transcriptional activator TtdR; Provisional; Region: PRK09801 1283330011815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330011816 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283330011817 putative effector binding pocket; other site 1283330011818 dimerization interface [polypeptide binding]; other site 1283330011819 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1283330011820 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1283330011821 putative NAD(P) binding site [chemical binding]; other site 1283330011822 glycolate transporter; Provisional; Region: PRK09695 1283330011823 L-lactate permease; Region: Lactate_perm; cl00701 1283330011824 malate synthase G; Provisional; Region: PRK02999 1283330011825 active site 1283330011826 Domain of unknown function (DUF336); Region: DUF336; cl01249 1283330011827 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1283330011828 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1283330011829 Cysteine-rich domain; Region: CCG; pfam02754 1283330011830 Cysteine-rich domain; Region: CCG; pfam02754 1283330011831 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1283330011832 FAD binding domain; Region: FAD_binding_4; pfam01565 1283330011833 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1283330011834 FAD binding domain; Region: FAD_binding_4; pfam01565 1283330011835 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 1283330011836 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283330011837 DNA-binding site [nucleotide binding]; DNA binding site 1283330011838 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1283330011839 enolase; Provisional; Region: eno; PRK00077 1283330011840 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1283330011841 dimer interface [polypeptide binding]; other site 1283330011842 metal binding site [ion binding]; metal-binding site 1283330011843 substrate binding pocket [chemical binding]; other site 1283330011844 pyruvate kinase; Provisional; Region: PRK05826 1283330011845 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1283330011846 domain interfaces; other site 1283330011847 active site 1283330011848 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1283330011849 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1283330011850 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1283330011851 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1283330011852 glyoxylate carboligase; Provisional; Region: PRK11269 1283330011853 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1283330011854 TPP binding site [chemical binding]; other site 1283330011855 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1283330011856 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1283330011857 TPP-binding site [chemical binding]; other site 1283330011858 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1283330011859 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1283330011860 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1283330011861 Pirin-related protein [General function prediction only]; Region: COG1741 1283330011862 Pirin; Region: Pirin; pfam02678 1283330011863 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1283330011864 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1283330011865 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1283330011866 CAP-like domain; other site 1283330011867 active site 1283330011868 primary dimer interface [polypeptide binding]; other site 1283330011869 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1283330011870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330011871 ATP binding site [chemical binding]; other site 1283330011872 Mg2+ binding site [ion binding]; other site 1283330011873 G-X-G motif; other site 1283330011874 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1283330011875 anchoring element; other site 1283330011876 dimer interface [polypeptide binding]; other site 1283330011877 ATP binding site [chemical binding]; other site 1283330011878 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1283330011879 active site 1283330011880 metal binding site [ion binding]; metal-binding site 1283330011881 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1283330011882 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1283330011883 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1283330011884 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1283330011885 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1283330011886 active site 1283330011887 metal binding site [ion binding]; metal-binding site 1283330011888 hexamer interface [polypeptide binding]; other site 1283330011889 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1283330011890 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1283330011891 putative ligand binding site [chemical binding]; other site 1283330011892 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1283330011893 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1283330011894 TM-ABC transporter signature motif; other site 1283330011895 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1283330011896 TM-ABC transporter signature motif; other site 1283330011897 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1283330011898 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1283330011899 Walker A/P-loop; other site 1283330011900 ATP binding site [chemical binding]; other site 1283330011901 Q-loop/lid; other site 1283330011902 ABC transporter signature motif; other site 1283330011903 Walker B; other site 1283330011904 D-loop; other site 1283330011905 H-loop/switch region; other site 1283330011906 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1283330011907 acyl-activating enzyme (AAE) consensus motif; other site 1283330011908 CoA binding site [chemical binding]; other site 1283330011909 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1283330011910 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1283330011911 active site 1283330011912 dimer interface [polypeptide binding]; other site 1283330011913 non-prolyl cis peptide bond; other site 1283330011914 insertion regions; other site 1283330011915 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1283330011916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330011917 non-specific DNA binding site [nucleotide binding]; other site 1283330011918 salt bridge; other site 1283330011919 sequence-specific DNA binding site [nucleotide binding]; other site 1283330011920 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1283330011921 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1283330011922 TM-ABC transporter signature motif; other site 1283330011923 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1283330011924 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1283330011925 TM-ABC transporter signature motif; other site 1283330011926 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1283330011927 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1283330011928 Walker A/P-loop; other site 1283330011929 ATP binding site [chemical binding]; other site 1283330011930 Q-loop/lid; other site 1283330011931 ABC transporter signature motif; other site 1283330011932 Walker B; other site 1283330011933 D-loop; other site 1283330011934 H-loop/switch region; other site 1283330011935 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1283330011936 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1283330011937 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283330011938 putative ligand binding site [chemical binding]; other site 1283330011939 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1283330011940 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283330011941 putative ligand binding site [chemical binding]; other site 1283330011942 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283330011943 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1283330011944 Flavin binding site [chemical binding]; other site 1283330011945 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283330011946 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1283330011947 Flavin binding site [chemical binding]; other site 1283330011948 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1283330011949 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1283330011950 putative ligand binding site [chemical binding]; other site 1283330011951 NAD binding site [chemical binding]; other site 1283330011952 catalytic site [active] 1283330011953 BON domain; Region: BON; pfam04972 1283330011954 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1283330011955 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1283330011956 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1283330011957 dimerization interface [polypeptide binding]; other site 1283330011958 active site 1283330011959 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1283330011960 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1283330011961 Walker A/P-loop; other site 1283330011962 ATP binding site [chemical binding]; other site 1283330011963 Q-loop/lid; other site 1283330011964 ABC transporter signature motif; other site 1283330011965 Walker B; other site 1283330011966 D-loop; other site 1283330011967 H-loop/switch region; other site 1283330011968 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1283330011969 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1283330011970 putative ligand binding site [chemical binding]; other site 1283330011971 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1283330011972 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1283330011973 putative ligand binding site [chemical binding]; other site 1283330011974 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283330011975 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1283330011976 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1283330011977 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1283330011978 putative ligand binding site [chemical binding]; other site 1283330011979 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1283330011980 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1283330011981 TM-ABC transporter signature motif; other site 1283330011982 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1283330011983 TM-ABC transporter signature motif; other site 1283330011984 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1283330011985 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1283330011986 Walker A/P-loop; other site 1283330011987 ATP binding site [chemical binding]; other site 1283330011988 Q-loop/lid; other site 1283330011989 ABC transporter signature motif; other site 1283330011990 Walker B; other site 1283330011991 D-loop; other site 1283330011992 H-loop/switch region; other site 1283330011993 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1283330011994 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283330011995 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283330011996 active site 1283330011997 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283330011998 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283330011999 active site 1283330012000 non-prolyl cis peptide bond; other site 1283330012001 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330012002 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1283330012003 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1283330012004 homodimer interface [polypeptide binding]; other site 1283330012005 substrate-cofactor binding pocket; other site 1283330012006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330012007 catalytic residue [active] 1283330012008 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1283330012009 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1283330012010 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1283330012011 active site 1283330012012 dimer interface [polypeptide binding]; other site 1283330012013 non-prolyl cis peptide bond; other site 1283330012014 insertion regions; other site 1283330012015 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283330012016 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1283330012017 Flavin binding site [chemical binding]; other site 1283330012018 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1283330012019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330012020 Walker A motif; other site 1283330012021 ATP binding site [chemical binding]; other site 1283330012022 Walker B motif; other site 1283330012023 arginine finger; other site 1283330012024 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1283330012025 Chromate transporter; Region: Chromate_transp; pfam02417 1283330012026 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1283330012027 IHF dimer interface [polypeptide binding]; other site 1283330012028 IHF - DNA interface [nucleotide binding]; other site 1283330012029 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283330012030 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283330012031 active site 1283330012032 non-prolyl cis peptide bond; other site 1283330012033 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283330012034 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330012035 N-terminal plug; other site 1283330012036 ligand-binding site [chemical binding]; other site 1283330012037 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1283330012038 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1283330012039 active site 1283330012040 non-prolyl cis peptide bond; other site 1283330012041 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1283330012042 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330012043 membrane-bound complex binding site; other site 1283330012044 hinge residues; other site 1283330012045 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1283330012046 intersubunit interface [polypeptide binding]; other site 1283330012047 active site 1283330012048 Zn2+ binding site [ion binding]; other site 1283330012049 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330012050 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330012051 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1283330012052 putative dimerization interface [polypeptide binding]; other site 1283330012053 transmembrane helices; other site 1283330012054 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1283330012055 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1283330012056 Protein of unknown function (DUF3141); Region: DUF3141; pfam11339 1283330012057 phosphate acetyltransferase; Provisional; Region: PRK11890 1283330012058 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 1283330012059 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 1283330012060 propionate/acetate kinase; Provisional; Region: PRK12379 1283330012061 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 1283330012062 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1283330012063 NAD binding site [chemical binding]; other site 1283330012064 homotetramer interface [polypeptide binding]; other site 1283330012065 homodimer interface [polypeptide binding]; other site 1283330012066 substrate binding site [chemical binding]; other site 1283330012067 active site 1283330012068 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1283330012069 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283330012070 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283330012071 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1283330012072 Paraquat-inducible protein A; Region: PqiA; pfam04403 1283330012073 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 1283330012074 Paraquat-inducible protein A; Region: PqiA; pfam04403 1283330012075 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1283330012076 mce related protein; Region: MCE; pfam02470 1283330012077 mce related protein; Region: MCE; pfam02470 1283330012078 mce related protein; Region: MCE; pfam02470 1283330012079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1283330012080 Transposase; Region: HTH_Tnp_1; pfam01527 1283330012081 Integrase core domain; Region: rve; pfam00665 1283330012082 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283330012083 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283330012084 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330012085 N-terminal plug; other site 1283330012086 ligand-binding site [chemical binding]; other site 1283330012087 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283330012088 FecR protein; Region: FecR; pfam04773 1283330012089 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1283330012090 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330012091 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330012092 DNA binding residues [nucleotide binding] 1283330012093 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1283330012094 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1283330012095 Ion channel; Region: Ion_trans_2; pfam07885 1283330012096 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 1283330012097 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1283330012098 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283330012099 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283330012100 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1283330012101 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1283330012102 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1283330012103 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283330012104 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1283330012105 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330012106 Walker A/P-loop; other site 1283330012107 ATP binding site [chemical binding]; other site 1283330012108 Q-loop/lid; other site 1283330012109 ABC transporter signature motif; other site 1283330012110 Walker B; other site 1283330012111 D-loop; other site 1283330012112 H-loop/switch region; other site 1283330012113 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1283330012114 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1283330012115 substrate-cofactor binding pocket; other site 1283330012116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330012117 catalytic residue [active] 1283330012118 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1283330012119 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1283330012120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330012121 NAD(P) binding site [chemical binding]; other site 1283330012122 active site 1283330012123 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 1283330012124 active site 1283330012125 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 1283330012126 active site 1283330012127 metal-binding site 1283330012128 Predicted permeases [General function prediction only]; Region: COG0795 1283330012129 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1283330012130 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1283330012131 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1283330012132 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1283330012133 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1283330012134 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 1283330012135 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1283330012136 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 1283330012137 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1283330012138 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 1283330012139 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1283330012140 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1283330012141 active site 1283330012142 metal binding site [ion binding]; metal-binding site 1283330012143 Phosphotransferase enzyme family; Region: APH; pfam01636 1283330012144 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1283330012145 active site 1283330012146 ATP binding site [chemical binding]; other site 1283330012147 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1283330012148 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1283330012149 active site 1283330012150 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1283330012151 CHASE domain; Region: CHASE; pfam03924 1283330012152 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330012153 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330012154 metal binding site [ion binding]; metal-binding site 1283330012155 active site 1283330012156 I-site; other site 1283330012157 Predicted permeases [General function prediction only]; Region: COG0679 1283330012158 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1283330012159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330012160 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1283330012161 dimerization interface [polypeptide binding]; other site 1283330012162 substrate binding pocket [chemical binding]; other site 1283330012163 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283330012164 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1283330012165 active site 1283330012166 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1283330012167 substrate binding pocket [chemical binding]; other site 1283330012168 membrane-bound complex binding site; other site 1283330012169 hinge residues; other site 1283330012170 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1283330012171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330012172 dimer interface [polypeptide binding]; other site 1283330012173 conserved gate region; other site 1283330012174 putative PBP binding loops; other site 1283330012175 ABC-ATPase subunit interface; other site 1283330012176 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1283330012177 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1283330012178 Walker A/P-loop; other site 1283330012179 ATP binding site [chemical binding]; other site 1283330012180 Q-loop/lid; other site 1283330012181 ABC transporter signature motif; other site 1283330012182 Walker B; other site 1283330012183 D-loop; other site 1283330012184 H-loop/switch region; other site 1283330012185 NMT1/THI5 like; Region: NMT1; pfam09084 1283330012186 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1283330012187 Protein of unknown function (DUF1249); Region: DUF1249; cl01223 1283330012188 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1283330012189 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1283330012190 dimer interface [polypeptide binding]; other site 1283330012191 ADP-ribose binding site [chemical binding]; other site 1283330012192 active site 1283330012193 nudix motif; other site 1283330012194 metal binding site [ion binding]; metal-binding site 1283330012195 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1283330012196 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1283330012197 ThiC-associated domain; Region: ThiC-associated; pfam13667 1283330012198 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1283330012199 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1283330012200 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1283330012201 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1283330012202 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1283330012203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1283330012204 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283330012205 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283330012206 active site 1283330012207 catalytic tetrad [active] 1283330012208 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283330012209 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283330012210 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283330012211 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330012212 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330012213 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1283330012214 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1283330012215 putative ribose interaction site [chemical binding]; other site 1283330012216 putative ADP binding site [chemical binding]; other site 1283330012217 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1283330012218 active site 1283330012219 nucleotide binding site [chemical binding]; other site 1283330012220 HIGH motif; other site 1283330012221 KMSKS motif; other site 1283330012222 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1283330012223 Mig-14; Region: Mig-14; pfam07395 1283330012224 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1283330012225 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1283330012226 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1283330012227 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1283330012228 Walker A/P-loop; other site 1283330012229 ATP binding site [chemical binding]; other site 1283330012230 Q-loop/lid; other site 1283330012231 ABC transporter signature motif; other site 1283330012232 Walker B; other site 1283330012233 D-loop; other site 1283330012234 H-loop/switch region; other site 1283330012235 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1283330012236 active site 1283330012237 ATP binding site [chemical binding]; other site 1283330012238 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1283330012239 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1283330012240 NAD binding site [chemical binding]; other site 1283330012241 homodimer interface [polypeptide binding]; other site 1283330012242 active site 1283330012243 substrate binding site [chemical binding]; other site 1283330012244 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1283330012245 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1283330012246 Ligand binding site; other site 1283330012247 metal-binding site 1283330012248 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1283330012249 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1283330012250 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1283330012251 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1283330012252 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283330012253 putative ADP-binding pocket [chemical binding]; other site 1283330012254 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1283330012255 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1283330012256 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1283330012257 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1283330012258 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1283330012259 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1283330012260 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1283330012261 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1283330012262 putative active site [active] 1283330012263 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1283330012264 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1283330012265 putative active site [active] 1283330012266 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1283330012267 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1283330012268 homodimer interface [polypeptide binding]; other site 1283330012269 substrate-cofactor binding pocket; other site 1283330012270 catalytic residue [active] 1283330012271 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1283330012272 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1283330012273 metal binding triad; other site 1283330012274 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1283330012275 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1283330012276 metal binding triad; other site 1283330012277 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1283330012278 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1283330012279 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1283330012280 dimer interface [polypeptide binding]; other site 1283330012281 TPP-binding site [chemical binding]; other site 1283330012282 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1283330012283 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1283330012284 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1283330012285 E3 interaction surface; other site 1283330012286 lipoyl attachment site [posttranslational modification]; other site 1283330012287 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1283330012288 E3 interaction surface; other site 1283330012289 lipoyl attachment site [posttranslational modification]; other site 1283330012290 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1283330012291 E3 interaction surface; other site 1283330012292 lipoyl attachment site [posttranslational modification]; other site 1283330012293 e3 binding domain; Region: E3_binding; pfam02817 1283330012294 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1283330012295 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1283330012296 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1283330012297 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1283330012298 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1283330012299 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1283330012300 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1283330012301 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283330012302 Ligand Binding Site [chemical binding]; other site 1283330012303 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283330012304 Ligand Binding Site [chemical binding]; other site 1283330012305 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1283330012306 AAA domain; Region: AAA_33; pfam13671 1283330012307 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1283330012308 active site 1283330012309 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283330012310 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 1283330012311 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330012312 N-terminal plug; other site 1283330012313 ligand-binding site [chemical binding]; other site 1283330012314 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 1283330012315 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1283330012316 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283330012317 FecR protein; Region: FecR; pfam04773 1283330012318 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330012319 RNA polymerase sigma factor; Reviewed; Region: PRK12527 1283330012320 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330012321 DNA binding residues [nucleotide binding] 1283330012322 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1283330012323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330012324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330012325 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283330012326 dimerization interface [polypeptide binding]; other site 1283330012327 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1283330012328 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1283330012329 active site 1 [active] 1283330012330 dimer interface [polypeptide binding]; other site 1283330012331 hexamer interface [polypeptide binding]; other site 1283330012332 active site 2 [active] 1283330012333 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1283330012334 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1283330012335 TrkA-C domain; Region: TrkA_C; pfam02080 1283330012336 Transporter associated domain; Region: CorC_HlyC; smart01091 1283330012337 hypothetical protein; Provisional; Region: PRK11281 1283330012338 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1283330012339 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1283330012340 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1283330012341 hypothetical protein; Validated; Region: PRK00029 1283330012342 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1283330012343 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1283330012344 thioredoxin 2; Provisional; Region: PRK10996 1283330012345 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1283330012346 catalytic residues [active] 1283330012347 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283330012348 Ligand Binding Site [chemical binding]; other site 1283330012349 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283330012350 Ligand Binding Site [chemical binding]; other site 1283330012351 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1283330012352 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1283330012353 P-loop; other site 1283330012354 Magnesium ion binding site [ion binding]; other site 1283330012355 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1283330012356 Magnesium ion binding site [ion binding]; other site 1283330012357 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1283330012358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330012359 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1283330012360 dimerization interface [polypeptide binding]; other site 1283330012361 substrate binding pocket [chemical binding]; other site 1283330012362 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283330012363 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1283330012364 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1283330012365 substrate binding site [chemical binding]; other site 1283330012366 active site 1283330012367 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1283330012368 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1283330012369 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1283330012370 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1283330012371 active site 1283330012372 dimer interface [polypeptide binding]; other site 1283330012373 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1283330012374 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1283330012375 active site 1283330012376 FMN binding site [chemical binding]; other site 1283330012377 substrate binding site [chemical binding]; other site 1283330012378 3Fe-4S cluster binding site [ion binding]; other site 1283330012379 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1283330012380 domain interface; other site 1283330012381 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 1283330012382 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1283330012383 Sporulation related domain; Region: SPOR; pfam05036 1283330012384 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1283330012385 active site 1283330012386 dimer interface [polypeptide binding]; other site 1283330012387 metal binding site [ion binding]; metal-binding site 1283330012388 shikimate kinase; Reviewed; Region: aroK; PRK00131 1283330012389 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1283330012390 ADP binding site [chemical binding]; other site 1283330012391 magnesium binding site [ion binding]; other site 1283330012392 putative shikimate binding site; other site 1283330012393 AMIN domain; Region: AMIN; pfam11741 1283330012394 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1283330012395 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283330012396 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1283330012397 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1283330012398 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 1283330012399 Pilus assembly protein, PilP; Region: PilP; pfam04351 1283330012400 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 1283330012401 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1283330012402 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1283330012403 Competence protein A; Region: Competence_A; pfam11104 1283330012404 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1283330012405 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1283330012406 Transglycosylase; Region: Transgly; pfam00912 1283330012407 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1283330012408 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1283330012409 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1283330012410 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1283330012411 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1283330012412 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1283330012413 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1283330012414 putative NAD(P) binding site [chemical binding]; other site 1283330012415 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1283330012416 primosome assembly protein PriA; Validated; Region: PRK05580 1283330012417 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283330012418 ATP binding site [chemical binding]; other site 1283330012419 putative Mg++ binding site [ion binding]; other site 1283330012420 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1283330012421 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 1283330012422 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1283330012423 ATP-binding site [chemical binding]; other site 1283330012424 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1283330012425 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1283330012426 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1283330012427 active site 1283330012428 HIGH motif; other site 1283330012429 KMSK motif region; other site 1283330012430 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1283330012431 tRNA binding surface [nucleotide binding]; other site 1283330012432 anticodon binding site; other site 1283330012433 Sporulation related domain; Region: SPOR; pfam05036 1283330012434 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1283330012435 active site 1283330012436 HslU subunit interaction site [polypeptide binding]; other site 1283330012437 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1283330012438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330012439 Walker A motif; other site 1283330012440 ATP binding site [chemical binding]; other site 1283330012441 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1283330012442 Walker B motif; other site 1283330012443 arginine finger; other site 1283330012444 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1283330012445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 1283330012446 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1283330012447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330012448 S-adenosylmethionine binding site [chemical binding]; other site 1283330012449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1283330012450 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1283330012451 ABC1 family; Region: ABC1; cl17513 1283330012452 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1283330012453 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1283330012454 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1283330012455 metal binding site [ion binding]; metal-binding site 1283330012456 twin arginine translocase protein A; Provisional; Region: tatA; PRK00442 1283330012457 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1283330012458 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 1283330012459 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1283330012460 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1283330012461 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1283330012462 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1283330012463 Ligand binding site; other site 1283330012464 DXD motif; other site 1283330012465 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1283330012466 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1283330012467 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1283330012468 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1283330012469 Ligand binding site; other site 1283330012470 DXD motif; other site 1283330012471 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1283330012472 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 1283330012473 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 1283330012474 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1283330012475 putative active site [active] 1283330012476 dimerization interface [polypeptide binding]; other site 1283330012477 putative tRNAtyr binding site [nucleotide binding]; other site 1283330012478 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1283330012479 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1283330012480 TAP-like protein; Region: Abhydrolase_4; pfam08386 1283330012481 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 1283330012482 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1283330012483 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1283330012484 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1283330012485 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1283330012486 active site 1283330012487 Cupin domain; Region: Cupin_2; cl17218 1283330012488 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1283330012489 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1283330012490 fructose-1,6-bisphosphatase family protein; Region: PLN02628 1283330012491 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1283330012492 AMP binding site [chemical binding]; other site 1283330012493 metal binding site [ion binding]; metal-binding site 1283330012494 active site 1283330012495 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1283330012496 homodimer interface [polypeptide binding]; other site 1283330012497 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1283330012498 active site pocket [active] 1283330012499 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1283330012500 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1283330012501 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1283330012502 amphipathic channel; other site 1283330012503 Asn-Pro-Ala signature motifs; other site 1283330012504 glycerol kinase; Provisional; Region: glpK; PRK00047 1283330012505 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1283330012506 N- and C-terminal domain interface [polypeptide binding]; other site 1283330012507 active site 1283330012508 MgATP binding site [chemical binding]; other site 1283330012509 catalytic site [active] 1283330012510 metal binding site [ion binding]; metal-binding site 1283330012511 glycerol binding site [chemical binding]; other site 1283330012512 homotetramer interface [polypeptide binding]; other site 1283330012513 homodimer interface [polypeptide binding]; other site 1283330012514 FBP binding site [chemical binding]; other site 1283330012515 protein IIAGlc interface [polypeptide binding]; other site 1283330012516 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1283330012517 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1283330012518 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1283330012519 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1283330012520 enolase; Provisional; Region: eno; PRK00077 1283330012521 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1283330012522 dimer interface [polypeptide binding]; other site 1283330012523 metal binding site [ion binding]; metal-binding site 1283330012524 substrate binding pocket [chemical binding]; other site 1283330012525 triosephosphate isomerase; Provisional; Region: PRK14567 1283330012526 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1283330012527 substrate binding site [chemical binding]; other site 1283330012528 dimer interface [polypeptide binding]; other site 1283330012529 catalytic triad [active] 1283330012530 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1283330012531 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1283330012532 NAD(P) binding site [chemical binding]; other site 1283330012533 catalytic residues [active] 1283330012534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283330012535 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283330012536 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283330012537 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330012538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330012539 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1283330012540 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283330012541 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1283330012542 putative active site [active] 1283330012543 putative NTP binding site [chemical binding]; other site 1283330012544 putative nucleic acid binding site [nucleotide binding]; other site 1283330012545 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1283330012546 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1283330012547 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1283330012548 G1 box; other site 1283330012549 putative GEF interaction site [polypeptide binding]; other site 1283330012550 GTP/Mg2+ binding site [chemical binding]; other site 1283330012551 Switch I region; other site 1283330012552 G2 box; other site 1283330012553 G3 box; other site 1283330012554 Switch II region; other site 1283330012555 G4 box; other site 1283330012556 G5 box; other site 1283330012557 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1283330012558 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1283330012559 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1283330012560 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1283330012561 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1283330012562 Ligand Binding Site [chemical binding]; other site 1283330012563 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1283330012564 active site residue [active] 1283330012565 glutamine synthetase; Provisional; Region: glnA; PRK09469 1283330012566 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1283330012567 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1283330012568 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1283330012569 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1283330012570 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1283330012571 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330012572 dimer interface [polypeptide binding]; other site 1283330012573 phosphorylation site [posttranslational modification] 1283330012574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330012575 ATP binding site [chemical binding]; other site 1283330012576 Mg2+ binding site [ion binding]; other site 1283330012577 G-X-G motif; other site 1283330012578 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1283330012579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330012580 active site 1283330012581 phosphorylation site [posttranslational modification] 1283330012582 intermolecular recognition site; other site 1283330012583 dimerization interface [polypeptide binding]; other site 1283330012584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330012585 Walker A motif; other site 1283330012586 ATP binding site [chemical binding]; other site 1283330012587 Walker B motif; other site 1283330012588 arginine finger; other site 1283330012589 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330012590 peroxiredoxin; Region: AhpC; TIGR03137 1283330012591 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1283330012592 dimer interface [polypeptide binding]; other site 1283330012593 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1283330012594 catalytic triad [active] 1283330012595 peroxidatic and resolving cysteines [active] 1283330012596 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1283330012597 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1283330012598 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1283330012599 active site 1283330012600 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1283330012601 AAA domain; Region: AAA_26; pfam13500 1283330012602 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1283330012603 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1283330012604 dimer interface [polypeptide binding]; other site 1283330012605 FMN binding site [chemical binding]; other site 1283330012606 NADPH bind site [chemical binding]; other site 1283330012607 flavodoxin FldA; Validated; Region: PRK09267 1283330012608 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1283330012609 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1283330012610 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1283330012611 active site 1283330012612 HIGH motif; other site 1283330012613 dimer interface [polypeptide binding]; other site 1283330012614 KMSKS motif; other site 1283330012615 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1283330012616 putative peptidase; Provisional; Region: PRK11649 1283330012617 Peptidase family M23; Region: Peptidase_M23; pfam01551 1283330012618 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1283330012619 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1283330012620 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1283330012621 putative active site [active] 1283330012622 putative NTP binding site [chemical binding]; other site 1283330012623 putative nucleic acid binding site [nucleotide binding]; other site 1283330012624 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1283330012625 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1283330012626 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1283330012627 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1283330012628 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1283330012629 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1283330012630 nucleotide binding site/active site [active] 1283330012631 HIT family signature motif; other site 1283330012632 catalytic residue [active] 1283330012633 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 1283330012634 diiron binding motif [ion binding]; other site 1283330012635 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1283330012636 OsmC-like protein; Region: OsmC; cl00767 1283330012637 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1283330012638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1283330012639 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1283330012640 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1283330012641 ligand binding site [chemical binding]; other site 1283330012642 flexible hinge region; other site 1283330012643 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1283330012644 putative switch regulator; other site 1283330012645 non-specific DNA interactions [nucleotide binding]; other site 1283330012646 DNA binding site [nucleotide binding] 1283330012647 sequence specific DNA binding site [nucleotide binding]; other site 1283330012648 putative cAMP binding site [chemical binding]; other site 1283330012649 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1283330012650 active site 1283330012651 ribulose/triose binding site [chemical binding]; other site 1283330012652 phosphate binding site [ion binding]; other site 1283330012653 substrate (anthranilate) binding pocket [chemical binding]; other site 1283330012654 product (indole) binding pocket [chemical binding]; other site 1283330012655 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1283330012656 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1283330012657 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1283330012658 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1283330012659 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1283330012660 glutamine binding [chemical binding]; other site 1283330012661 catalytic triad [active] 1283330012662 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1283330012663 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1283330012664 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1283330012665 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1283330012666 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1283330012667 alpha subunit interface [polypeptide binding]; other site 1283330012668 TPP binding site [chemical binding]; other site 1283330012669 heterodimer interface [polypeptide binding]; other site 1283330012670 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1283330012671 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1283330012672 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1283330012673 tetramer interface [polypeptide binding]; other site 1283330012674 TPP-binding site [chemical binding]; other site 1283330012675 heterodimer interface [polypeptide binding]; other site 1283330012676 phosphorylation loop region [posttranslational modification] 1283330012677 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1283330012678 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 1283330012679 DNA binding residues [nucleotide binding] 1283330012680 dimer interface [polypeptide binding]; other site 1283330012681 putative metal binding site [ion binding]; other site 1283330012682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1283330012683 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 1283330012684 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1283330012685 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283330012686 active site 1283330012687 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1283330012688 catalytic triad [active] 1283330012689 metal binding site [ion binding]; metal-binding site 1283330012690 conserved cis-peptide bond; other site 1283330012691 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1283330012692 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1283330012693 active site 1283330012694 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1283330012695 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1283330012696 putative active site [active] 1283330012697 putative metal binding site [ion binding]; other site 1283330012698 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1283330012699 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 1283330012700 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1283330012701 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1283330012702 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1283330012703 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1283330012704 DNA binding site [nucleotide binding] 1283330012705 active site 1283330012706 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 1283330012707 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1283330012708 catalytic site [active] 1283330012709 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 1283330012710 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1283330012711 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1283330012712 protein binding site [polypeptide binding]; other site 1283330012713 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1283330012714 active site 1283330012715 catalytic residues [active] 1283330012716 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1283330012717 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330012718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330012719 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1283330012720 putative substrate binding pocket [chemical binding]; other site 1283330012721 putative dimerization interface [polypeptide binding]; other site 1283330012722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330012723 putative substrate translocation pore; other site 1283330012724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330012725 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1283330012726 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283330012727 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283330012728 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1283330012729 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1283330012730 Ligand Binding Site [chemical binding]; other site 1283330012731 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1283330012732 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1283330012733 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1283330012734 dimer interaction site [polypeptide binding]; other site 1283330012735 substrate-binding tunnel; other site 1283330012736 active site 1283330012737 catalytic site [active] 1283330012738 substrate binding site [chemical binding]; other site 1283330012739 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1283330012740 oligomerization interface [polypeptide binding]; other site 1283330012741 active site 1283330012742 metal binding site [ion binding]; metal-binding site 1283330012743 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1283330012744 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1283330012745 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283330012746 putative DNA binding site [nucleotide binding]; other site 1283330012747 putative Zn2+ binding site [ion binding]; other site 1283330012748 AsnC family; Region: AsnC_trans_reg; pfam01037 1283330012749 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330012750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330012751 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1283330012752 putative dimerization interface [polypeptide binding]; other site 1283330012753 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 1283330012754 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 1283330012755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1283330012756 TPR motif; other site 1283330012757 binding surface 1283330012758 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1283330012759 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1283330012760 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1283330012761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330012762 active site 1283330012763 phosphorylation site [posttranslational modification] 1283330012764 intermolecular recognition site; other site 1283330012765 dimerization interface [polypeptide binding]; other site 1283330012766 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283330012767 DNA binding site [nucleotide binding] 1283330012768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283330012769 dimerization interface [polypeptide binding]; other site 1283330012770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330012771 dimer interface [polypeptide binding]; other site 1283330012772 phosphorylation site [posttranslational modification] 1283330012773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330012774 ATP binding site [chemical binding]; other site 1283330012775 Mg2+ binding site [ion binding]; other site 1283330012776 G-X-G motif; other site 1283330012777 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1283330012778 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1283330012779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1283330012780 anthranilate synthase component I; Provisional; Region: PRK13565 1283330012781 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1283330012782 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1283330012783 putative active site [active] 1283330012784 anthranilate synthase component I; Provisional; Region: PRK13565 1283330012785 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1283330012786 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1283330012787 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 1283330012788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330012789 motif II; other site 1283330012790 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1283330012791 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1283330012792 substrate binding site [chemical binding]; other site 1283330012793 hexamer interface [polypeptide binding]; other site 1283330012794 metal binding site [ion binding]; metal-binding site 1283330012795 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1283330012796 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1283330012797 inhibitor-cofactor binding pocket; inhibition site 1283330012798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330012799 catalytic residue [active] 1283330012800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330012801 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1283330012802 dimerization interface [polypeptide binding]; other site 1283330012803 substrate binding pocket [chemical binding]; other site 1283330012804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1283330012805 active site 1283330012806 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1283330012807 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1283330012808 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1283330012809 shikimate binding site; other site 1283330012810 NAD(P) binding site [chemical binding]; other site 1283330012811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330012812 putative substrate translocation pore; other site 1283330012813 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1283330012814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330012815 D-galactonate transporter; Region: 2A0114; TIGR00893 1283330012816 putative substrate translocation pore; other site 1283330012817 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1283330012818 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 1283330012819 NADP binding site [chemical binding]; other site 1283330012820 homodimer interface [polypeptide binding]; other site 1283330012821 active site 1283330012822 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1283330012823 putative metal binding site [ion binding]; other site 1283330012824 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 1283330012825 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1283330012826 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1283330012827 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1283330012828 Substrate binding site; other site 1283330012829 metal-binding site 1283330012830 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1283330012831 Phosphotransferase enzyme family; Region: APH; pfam01636 1283330012832 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1283330012833 OstA-like protein; Region: OstA; cl00844 1283330012834 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1283330012835 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1283330012836 SurA N-terminal domain; Region: SurA_N; pfam09312 1283330012837 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1283330012838 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 1283330012839 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1283330012840 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1283330012841 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1283330012842 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1283330012843 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1283330012844 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1283330012845 active site 1283330012846 metal binding site [ion binding]; metal-binding site 1283330012847 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1283330012848 active site residue [active] 1283330012849 PrkA family serine protein kinase; Provisional; Region: PRK15455 1283330012850 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1283330012851 hypothetical protein; Provisional; Region: PRK05325 1283330012852 SpoVR family protein; Provisional; Region: PRK11767 1283330012853 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1283330012854 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1283330012855 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1283330012856 active site 1283330012857 NTP binding site [chemical binding]; other site 1283330012858 metal binding triad [ion binding]; metal-binding site 1283330012859 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1283330012860 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1283330012861 Zn2+ binding site [ion binding]; other site 1283330012862 Mg2+ binding site [ion binding]; other site 1283330012863 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1283330012864 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1283330012865 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1283330012866 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1283330012867 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1283330012868 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1283330012869 active site residue [active] 1283330012870 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1283330012871 catalytic center binding site [active] 1283330012872 ATP binding site [chemical binding]; other site 1283330012873 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 1283330012874 active site 1283330012875 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1283330012876 UGMP family protein; Validated; Region: PRK09604 1283330012877 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1283330012878 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1283330012879 DNA primase; Validated; Region: dnaG; PRK05667 1283330012880 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1283330012881 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1283330012882 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1283330012883 active site 1283330012884 metal binding site [ion binding]; metal-binding site 1283330012885 interdomain interaction site; other site 1283330012886 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1283330012887 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1283330012888 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1283330012889 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1283330012890 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1283330012891 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1283330012892 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330012893 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1283330012894 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330012895 DNA binding residues [nucleotide binding] 1283330012896 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1283330012897 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1283330012898 ligand binding site [chemical binding]; other site 1283330012899 flexible hinge region; other site 1283330012900 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1283330012901 putative switch regulator; other site 1283330012902 non-specific DNA interactions [nucleotide binding]; other site 1283330012903 DNA binding site [nucleotide binding] 1283330012904 sequence specific DNA binding site [nucleotide binding]; other site 1283330012905 putative cAMP binding site [chemical binding]; other site 1283330012906 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1283330012907 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1283330012908 Repair protein; Region: Repair_PSII; pfam04536 1283330012909 Repair protein; Region: Repair_PSII; cl01535 1283330012910 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1283330012911 Competence-damaged protein; Region: CinA; pfam02464 1283330012912 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1283330012913 dimanganese center [ion binding]; other site 1283330012914 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1283330012915 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1283330012916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330012917 Walker A motif; other site 1283330012918 ATP binding site [chemical binding]; other site 1283330012919 Walker B motif; other site 1283330012920 arginine finger; other site 1283330012921 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330012922 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1283330012923 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283330012924 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1283330012925 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 1283330012926 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1283330012927 putative ligand binding residues [chemical binding]; other site 1283330012928 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1283330012929 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1283330012930 ABC-ATPase subunit interface; other site 1283330012931 dimer interface [polypeptide binding]; other site 1283330012932 putative PBP binding regions; other site 1283330012933 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1283330012934 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1283330012935 Walker A/P-loop; other site 1283330012936 ATP binding site [chemical binding]; other site 1283330012937 Q-loop/lid; other site 1283330012938 ABC transporter signature motif; other site 1283330012939 Walker B; other site 1283330012940 D-loop; other site 1283330012941 H-loop/switch region; other site 1283330012942 RNA polymerase sigma factor; Provisional; Region: PRK12528 1283330012943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330012944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330012945 DNA binding residues [nucleotide binding] 1283330012946 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1283330012947 FecR protein; Region: FecR; pfam04773 1283330012948 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1283330012949 Secretin and TonB N terminus short domain; Region: STN; smart00965 1283330012950 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330012951 N-terminal plug; other site 1283330012952 ligand-binding site [chemical binding]; other site 1283330012953 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1283330012954 CGNR zinc finger; Region: zf-CGNR; pfam11706 1283330012955 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1283330012956 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 1283330012957 Predicted membrane protein [Function unknown]; Region: COG3212 1283330012958 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1283330012959 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 1283330012960 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1283330012961 putative FMN binding site [chemical binding]; other site 1283330012962 glycine dehydrogenase; Provisional; Region: PRK05367 1283330012963 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1283330012964 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1283330012965 catalytic residue [active] 1283330012966 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1283330012967 tetramer interface [polypeptide binding]; other site 1283330012968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330012969 catalytic residue [active] 1283330012970 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1283330012971 lipoyl attachment site [posttranslational modification]; other site 1283330012972 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1283330012973 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1283330012974 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1283330012975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330012976 dimer interface [polypeptide binding]; other site 1283330012977 conserved gate region; other site 1283330012978 putative PBP binding loops; other site 1283330012979 ABC-ATPase subunit interface; other site 1283330012980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330012981 dimer interface [polypeptide binding]; other site 1283330012982 conserved gate region; other site 1283330012983 putative PBP binding loops; other site 1283330012984 ABC-ATPase subunit interface; other site 1283330012985 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1283330012986 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1283330012987 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK05714 1283330012988 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1283330012989 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 1283330012990 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1283330012991 proline aminopeptidase P II; Provisional; Region: PRK10879 1283330012992 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1283330012993 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1283330012994 active site 1283330012995 hypothetical protein; Reviewed; Region: PRK02166 1283330012996 TIGR02449 family protein; Region: TIGR02449 1283330012997 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 1283330012998 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1283330012999 EVE domain; Region: EVE; cl00728 1283330013000 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1283330013001 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1283330013002 catalytic loop [active] 1283330013003 iron binding site [ion binding]; other site 1283330013004 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1283330013005 FAD binding pocket [chemical binding]; other site 1283330013006 FAD binding motif [chemical binding]; other site 1283330013007 phosphate binding motif [ion binding]; other site 1283330013008 beta-alpha-beta structure motif; other site 1283330013009 NAD binding pocket [chemical binding]; other site 1283330013010 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1283330013011 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1283330013012 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1283330013013 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1283330013014 RNA binding site [nucleotide binding]; other site 1283330013015 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1283330013016 multimer interface [polypeptide binding]; other site 1283330013017 Walker A motif; other site 1283330013018 ATP binding site [chemical binding]; other site 1283330013019 Walker B motif; other site 1283330013020 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1283330013021 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1283330013022 catalytic residues [active] 1283330013023 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1283330013024 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1283330013025 polyphosphate kinase; Provisional; Region: PRK05443 1283330013026 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1283330013027 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1283330013028 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1283330013029 putative domain interface [polypeptide binding]; other site 1283330013030 putative active site [active] 1283330013031 catalytic site [active] 1283330013032 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1283330013033 putative domain interface [polypeptide binding]; other site 1283330013034 putative active site [active] 1283330013035 catalytic site [active] 1283330013036 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1283330013037 dimer interface [polypeptide binding]; other site 1283330013038 allosteric magnesium binding site [ion binding]; other site 1283330013039 active site 1283330013040 aspartate-rich active site metal binding site; other site 1283330013041 Schiff base residues; other site 1283330013042 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1283330013043 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1283330013044 conserved cys residue [active] 1283330013045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1283330013046 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1283330013047 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1283330013048 G1 box; other site 1283330013049 GTP/Mg2+ binding site [chemical binding]; other site 1283330013050 Switch I region; other site 1283330013051 G2 box; other site 1283330013052 G3 box; other site 1283330013053 Switch II region; other site 1283330013054 G4 box; other site 1283330013055 G5 box; other site 1283330013056 Nucleoside recognition; Region: Gate; pfam07670 1283330013057 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1283330013058 Nucleoside recognition; Region: Gate; pfam07670 1283330013059 FeoA domain; Region: FeoA; pfam04023 1283330013060 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1283330013061 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1283330013062 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283330013063 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283330013064 ABC transporter; Region: ABC_tran_2; pfam12848 1283330013065 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1283330013066 Protein of unknown function (DUF2390); Region: DUF2390; pfam09523 1283330013067 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 1283330013068 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; pfam04353 1283330013069 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1283330013070 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 1283330013071 HemY protein N-terminus; Region: HemY_N; pfam07219 1283330013072 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1283330013073 uroporphyrinogen-III synthase; Validated; Region: PRK05752 1283330013074 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1283330013075 active site 1283330013076 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1283330013077 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1283330013078 domain interfaces; other site 1283330013079 active site 1283330013080 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1283330013081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330013082 active site 1283330013083 phosphorylation site [posttranslational modification] 1283330013084 intermolecular recognition site; other site 1283330013085 dimerization interface [polypeptide binding]; other site 1283330013086 LytTr DNA-binding domain; Region: LytTR; pfam04397 1283330013087 argininosuccinate lyase; Provisional; Region: PRK00855 1283330013088 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1283330013089 active sites [active] 1283330013090 tetramer interface [polypeptide binding]; other site 1283330013091 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1283330013092 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 1283330013093 Cl binding site [ion binding]; other site 1283330013094 oligomer interface [polypeptide binding]; other site 1283330013095 TIGR02647 family protein; Region: DNA 1283330013096 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1283330013097 putative iron binding site [ion binding]; other site 1283330013098 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 1283330013099 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1283330013100 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1283330013101 active site 1283330013102 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1283330013103 substrate binding site [chemical binding]; other site 1283330013104 catalytic residues [active] 1283330013105 dimer interface [polypeptide binding]; other site 1283330013106 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1283330013107 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1283330013108 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1283330013109 Protein of unknown function, DUF484; Region: DUF484; cl17449 1283330013110 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1283330013111 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1283330013112 active site 1283330013113 DNA binding site [nucleotide binding] 1283330013114 Int/Topo IB signature motif; other site 1283330013115 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1283330013116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1283330013117 motif II; other site 1283330013118 CAAX protease self-immunity; Region: Abi; pfam02517 1283330013119 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1283330013120 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1283330013121 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1283330013122 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1283330013123 Membrane fusogenic activity; Region: BMFP; pfam04380 1283330013124 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1283330013125 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1283330013126 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1283330013127 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1283330013128 Predicted ATPase [General function prediction only]; Region: COG4637 1283330013129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330013130 Walker A/P-loop; other site 1283330013131 ATP binding site [chemical binding]; other site 1283330013132 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330013133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330013134 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1283330013135 putative effector binding pocket; other site 1283330013136 dimerization interface [polypeptide binding]; other site 1283330013137 Predicted membrane protein [Function unknown]; Region: COG2259 1283330013138 Pirin-related protein [General function prediction only]; Region: COG1741 1283330013139 Pirin; Region: Pirin; pfam02678 1283330013140 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 1283330013141 Part of AAA domain; Region: AAA_19; pfam13245 1283330013142 Family description; Region: UvrD_C_2; pfam13538 1283330013143 Staphylococcal nuclease homologues; Region: SNc; smart00318 1283330013144 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1283330013145 Catalytic site; other site 1283330013146 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1283330013147 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1283330013148 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1283330013149 putative heme binding pocket [chemical binding]; other site 1283330013150 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1283330013151 active site 1283330013152 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 1283330013153 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1283330013154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330013155 non-specific DNA binding site [nucleotide binding]; other site 1283330013156 salt bridge; other site 1283330013157 sequence-specific DNA binding site [nucleotide binding]; other site 1283330013158 Cupin domain; Region: Cupin_2; pfam07883 1283330013159 alanine racemase; Reviewed; Region: dadX; PRK03646 1283330013160 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1283330013161 active site 1283330013162 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1283330013163 substrate binding site [chemical binding]; other site 1283330013164 catalytic residues [active] 1283330013165 dimer interface [polypeptide binding]; other site 1283330013166 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1283330013167 homotrimer interaction site [polypeptide binding]; other site 1283330013168 putative active site [active] 1283330013169 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1283330013170 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283330013171 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1283330013172 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1283330013173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283330013174 putative DNA binding site [nucleotide binding]; other site 1283330013175 putative Zn2+ binding site [ion binding]; other site 1283330013176 AsnC family; Region: AsnC_trans_reg; pfam01037 1283330013177 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1283330013178 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1283330013179 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1283330013180 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1283330013181 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1283330013182 NAD(P) binding site [chemical binding]; other site 1283330013183 catalytic residues [active] 1283330013184 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1283330013185 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1283330013186 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1283330013187 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1283330013188 peptide binding site [polypeptide binding]; other site 1283330013189 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1283330013190 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1283330013191 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1283330013192 DNA binding residues [nucleotide binding] 1283330013193 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1283330013194 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1283330013195 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1283330013196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330013197 Walker A/P-loop; other site 1283330013198 ATP binding site [chemical binding]; other site 1283330013199 Q-loop/lid; other site 1283330013200 ABC transporter signature motif; other site 1283330013201 Walker B; other site 1283330013202 D-loop; other site 1283330013203 H-loop/switch region; other site 1283330013204 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1283330013205 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1283330013206 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1283330013207 P loop; other site 1283330013208 GTP binding site [chemical binding]; other site 1283330013209 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1283330013210 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1283330013211 folate binding site [chemical binding]; other site 1283330013212 NADP+ binding site [chemical binding]; other site 1283330013213 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1283330013214 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 1283330013215 putative active site [active] 1283330013216 catalytic site [active] 1283330013217 putative metal binding site [ion binding]; other site 1283330013218 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 1283330013219 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1283330013220 G1 box; other site 1283330013221 GTP/Mg2+ binding site [chemical binding]; other site 1283330013222 G2 box; other site 1283330013223 Switch I region; other site 1283330013224 G3 box; other site 1283330013225 Switch II region; other site 1283330013226 G4 box; other site 1283330013227 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 1283330013228 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1283330013229 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1283330013230 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283330013231 DNA-binding site [nucleotide binding]; DNA binding site 1283330013232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1283330013233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330013234 homodimer interface [polypeptide binding]; other site 1283330013235 catalytic residue [active] 1283330013236 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1283330013237 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1283330013238 dimerization interface [polypeptide binding]; other site 1283330013239 active site 1283330013240 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1283330013241 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1283330013242 NRDE protein; Region: NRDE; cl01315 1283330013243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330013244 PAS fold; Region: PAS_3; pfam08447 1283330013245 putative active site [active] 1283330013246 heme pocket [chemical binding]; other site 1283330013247 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330013248 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330013249 metal binding site [ion binding]; metal-binding site 1283330013250 active site 1283330013251 I-site; other site 1283330013252 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1283330013253 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1283330013254 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1283330013255 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1283330013256 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1283330013257 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1283330013258 putative active site [active] 1283330013259 Ap4A binding site [chemical binding]; other site 1283330013260 nudix motif; other site 1283330013261 putative metal binding site [ion binding]; other site 1283330013262 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1283330013263 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1283330013264 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 1283330013265 threonine dehydratase; Reviewed; Region: PRK09224 1283330013266 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1283330013267 tetramer interface [polypeptide binding]; other site 1283330013268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330013269 catalytic residue [active] 1283330013270 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1283330013271 putative Ile/Val binding site [chemical binding]; other site 1283330013272 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1283330013273 putative Ile/Val binding site [chemical binding]; other site 1283330013274 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1283330013275 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1283330013276 active site 1283330013277 dimer interface [polypeptide binding]; other site 1283330013278 SdiA-regulated; Region: SdiA-regulated; pfam06977 1283330013279 SdiA-regulated; Region: SdiA-regulated; cd09971 1283330013280 putative active site [active] 1283330013281 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1283330013282 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1283330013283 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1283330013284 FAD binding domain; Region: FAD_binding_4; pfam01565 1283330013285 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1283330013286 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1283330013287 ligand binding site [chemical binding]; other site 1283330013288 NAD binding site [chemical binding]; other site 1283330013289 tetramer interface [polypeptide binding]; other site 1283330013290 catalytic site [active] 1283330013291 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1283330013292 L-serine binding site [chemical binding]; other site 1283330013293 ACT domain interface; other site 1283330013294 Predicted permeases [General function prediction only]; Region: COG0679 1283330013295 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1283330013296 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1283330013297 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1283330013298 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1283330013299 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 1283330013300 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1283330013301 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 1283330013302 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1283330013303 monoglyceride lipase; Provisional; Region: PHA02857 1283330013304 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1283330013305 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1283330013306 putative NAD(P) binding site [chemical binding]; other site 1283330013307 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1283330013308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330013309 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1283330013310 dimerization interface [polypeptide binding]; other site 1283330013311 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1283330013312 Y-family of DNA polymerases; Region: PolY; cl12025 1283330013313 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1283330013314 generic binding surface II; other site 1283330013315 ssDNA binding site; other site 1283330013316 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283330013317 ATP binding site [chemical binding]; other site 1283330013318 putative Mg++ binding site [ion binding]; other site 1283330013319 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283330013320 nucleotide binding region [chemical binding]; other site 1283330013321 ATP-binding site [chemical binding]; other site 1283330013322 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1283330013323 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1283330013324 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 1283330013325 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1283330013326 IHF dimer interface [polypeptide binding]; other site 1283330013327 IHF - DNA interface [nucleotide binding]; other site 1283330013328 Rubredoxin [Energy production and conversion]; Region: COG1773 1283330013329 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1283330013330 iron binding site [ion binding]; other site 1283330013331 Chorismate lyase; Region: Chor_lyase; cl01230 1283330013332 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1283330013333 UbiA prenyltransferase family; Region: UbiA; pfam01040 1283330013334 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1283330013335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330013336 active site 1283330013337 phosphorylation site [posttranslational modification] 1283330013338 intermolecular recognition site; other site 1283330013339 dimerization interface [polypeptide binding]; other site 1283330013340 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283330013341 DNA binding site [nucleotide binding] 1283330013342 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1283330013343 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1283330013344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330013345 putative active site [active] 1283330013346 heme pocket [chemical binding]; other site 1283330013347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330013348 dimer interface [polypeptide binding]; other site 1283330013349 phosphorylation site [posttranslational modification] 1283330013350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330013351 ATP binding site [chemical binding]; other site 1283330013352 Mg2+ binding site [ion binding]; other site 1283330013353 G-X-G motif; other site 1283330013354 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1283330013355 Domain of unknown function DUF21; Region: DUF21; pfam01595 1283330013356 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1283330013357 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1283330013358 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1283330013359 Peptidase family M23; Region: Peptidase_M23; pfam01551 1283330013360 transcriptional regulator PhoU; Provisional; Region: PRK11115 1283330013361 PhoU domain; Region: PhoU; pfam01895 1283330013362 PhoU domain; Region: PhoU; pfam01895 1283330013363 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 1283330013364 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1283330013365 Walker A/P-loop; other site 1283330013366 ATP binding site [chemical binding]; other site 1283330013367 Q-loop/lid; other site 1283330013368 ABC transporter signature motif; other site 1283330013369 Walker B; other site 1283330013370 D-loop; other site 1283330013371 H-loop/switch region; other site 1283330013372 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 1283330013373 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1283330013374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330013375 dimer interface [polypeptide binding]; other site 1283330013376 conserved gate region; other site 1283330013377 putative PBP binding loops; other site 1283330013378 ABC-ATPase subunit interface; other site 1283330013379 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 1283330013380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330013381 ABC-ATPase subunit interface; other site 1283330013382 PBP superfamily domain; Region: PBP_like_2; cl17296 1283330013383 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1283330013384 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1283330013385 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1283330013386 active site 1283330013387 phosphate binding residues; other site 1283330013388 catalytic residues [active] 1283330013389 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 1283330013390 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 1283330013391 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1283330013392 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1283330013393 ligand binding site [chemical binding]; other site 1283330013394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330013395 S-adenosylmethionine binding site [chemical binding]; other site 1283330013396 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 1283330013397 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1283330013398 NADPH bind site [chemical binding]; other site 1283330013399 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1283330013400 putative FMN binding site [chemical binding]; other site 1283330013401 NADPH bind site [chemical binding]; other site 1283330013402 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1283330013403 active site residue [active] 1283330013404 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1283330013405 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1283330013406 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 1283330013407 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1283330013408 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1283330013409 C-terminal domain interface [polypeptide binding]; other site 1283330013410 GSH binding site (G-site) [chemical binding]; other site 1283330013411 dimer interface [polypeptide binding]; other site 1283330013412 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1283330013413 dimer interface [polypeptide binding]; other site 1283330013414 substrate binding pocket (H-site) [chemical binding]; other site 1283330013415 N-terminal domain interface [polypeptide binding]; other site 1283330013416 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1283330013417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330013418 dimer interface [polypeptide binding]; other site 1283330013419 conserved gate region; other site 1283330013420 putative PBP binding loops; other site 1283330013421 ABC-ATPase subunit interface; other site 1283330013422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330013423 dimer interface [polypeptide binding]; other site 1283330013424 conserved gate region; other site 1283330013425 putative PBP binding loops; other site 1283330013426 ABC-ATPase subunit interface; other site 1283330013427 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1283330013428 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1283330013429 Walker A/P-loop; other site 1283330013430 ATP binding site [chemical binding]; other site 1283330013431 Q-loop/lid; other site 1283330013432 ABC transporter signature motif; other site 1283330013433 Walker B; other site 1283330013434 D-loop; other site 1283330013435 H-loop/switch region; other site 1283330013436 TOBE domain; Region: TOBE_2; pfam08402 1283330013437 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1283330013438 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1283330013439 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 1283330013440 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1283330013441 active site 1283330013442 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1283330013443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1283330013444 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1283330013445 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1283330013446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1283330013447 S-adenosylmethionine binding site [chemical binding]; other site 1283330013448 Predicted transcriptional regulator [Transcription]; Region: COG2944 1283330013449 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1283330013450 non-specific DNA binding site [nucleotide binding]; other site 1283330013451 salt bridge; other site 1283330013452 sequence-specific DNA binding site [nucleotide binding]; other site 1283330013453 putative aminotransferase; Validated; Region: PRK07480 1283330013454 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1283330013455 inhibitor-cofactor binding pocket; inhibition site 1283330013456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1283330013457 catalytic residue [active] 1283330013458 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1283330013459 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1283330013460 Peptidase C26; Region: Peptidase_C26; pfam07722 1283330013461 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1283330013462 catalytic triad [active] 1283330013463 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1283330013464 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1283330013465 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1283330013466 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1283330013467 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1283330013468 putative active site; other site 1283330013469 catalytic triad [active] 1283330013470 putative dimer interface [polypeptide binding]; other site 1283330013471 agmatine deiminase; Provisional; Region: PRK13551 1283330013472 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1283330013473 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283330013474 dimerization interface [polypeptide binding]; other site 1283330013475 putative DNA binding site [nucleotide binding]; other site 1283330013476 putative Zn2+ binding site [ion binding]; other site 1283330013477 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330013478 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330013479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330013480 metal binding site [ion binding]; metal-binding site 1283330013481 active site 1283330013482 I-site; other site 1283330013483 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1283330013484 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1283330013485 Di-iron ligands [ion binding]; other site 1283330013486 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1283330013487 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1283330013488 putative active site pocket [active] 1283330013489 dimerization interface [polypeptide binding]; other site 1283330013490 putative catalytic residue [active] 1283330013491 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; pfam09582 1283330013492 Nitrogenase_VFe_beta -like: Nitrogenase VFe protein, beta subunit like. This group contains proteins similar to the beta subunits of the VFe protein of the vanadium-dependent (V-) nitrogenase. Nitrogenase catalyzes the ATP-dependent reduction of...; Region: Nitrogenase_VFe_beta_like; cd01973 1283330013493 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1283330013494 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; pfam03139 1283330013495 nitrogenase iron-iron protein, alpha chain; Region: ANFD; TIGR01861 1283330013496 Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of, the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977 1283330013497 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; Region: Fer4_NifH; pfam00142 1283330013498 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1283330013499 Nucleotide-binding sites [chemical binding]; other site 1283330013500 Walker A motif; other site 1283330013501 Switch I region of nucleotide binding site; other site 1283330013502 Fe4S4 binding sites [ion binding]; other site 1283330013503 Switch II region of nucleotide binding site; other site 1283330013504 Nif-specific regulatory protein; Region: nifA; TIGR01817 1283330013505 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1283330013506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330013507 Walker A motif; other site 1283330013508 ATP binding site [chemical binding]; other site 1283330013509 Walker B motif; other site 1283330013510 arginine finger; other site 1283330013511 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330013512 NifU-like domain; Region: NifU; cl00484 1283330013513 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1283330013514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330013515 PAS domain; Region: PAS_9; pfam13426 1283330013516 putative active site [active] 1283330013517 heme pocket [chemical binding]; other site 1283330013518 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330013519 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330013520 metal binding site [ion binding]; metal-binding site 1283330013521 active site 1283330013522 I-site; other site 1283330013523 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283330013524 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 1283330013525 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1283330013526 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1283330013527 tetramerization interface [polypeptide binding]; other site 1283330013528 NAD(P) binding site [chemical binding]; other site 1283330013529 catalytic residues [active] 1283330013530 Cytochrome C' Region: Cytochrom_C_2; pfam01322 1283330013531 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1283330013532 OsmC-like protein; Region: OsmC; pfam02566 1283330013533 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283330013534 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283330013535 active site 1283330013536 catalytic tetrad [active] 1283330013537 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1283330013538 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1283330013539 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1283330013540 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330013541 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330013542 metal binding site [ion binding]; metal-binding site 1283330013543 active site 1283330013544 I-site; other site 1283330013545 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283330013546 PGAP1-like protein; Region: PGAP1; pfam07819 1283330013547 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1283330013548 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1283330013549 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283330013550 ligand binding site [chemical binding]; other site 1283330013551 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1283330013552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1283330013553 DNA-binding site [nucleotide binding]; DNA binding site 1283330013554 FCD domain; Region: FCD; pfam07729 1283330013555 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1283330013556 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1283330013557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330013558 putative substrate translocation pore; other site 1283330013559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 1283330013560 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1283330013561 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1283330013562 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1283330013563 dimer interface [polypeptide binding]; other site 1283330013564 NADP binding site [chemical binding]; other site 1283330013565 catalytic residues [active] 1283330013566 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330013567 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330013568 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1283330013569 active sites [active] 1283330013570 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 1283330013571 tetramer interface [polypeptide binding]; other site 1283330013572 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1283330013573 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1283330013574 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1283330013575 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330013576 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 1283330013577 putative dimerization interface [polypeptide binding]; other site 1283330013578 putative substrate binding pocket [chemical binding]; other site 1283330013579 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330013580 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330013581 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330013582 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330013583 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330013584 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330013585 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1283330013586 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330013587 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330013588 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330013589 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330013590 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330013591 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330013592 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1283330013593 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1283330013594 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283330013595 Right handed beta helix region; Region: Beta_helix; pfam13229 1283330013596 Protein of unknown function (DUF2790); Region: DUF2790; pfam10976 1283330013597 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1283330013598 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1283330013599 HAMP domain; Region: HAMP; pfam00672 1283330013600 dimerization interface [polypeptide binding]; other site 1283330013601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330013602 dimer interface [polypeptide binding]; other site 1283330013603 phosphorylation site [posttranslational modification] 1283330013604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330013605 ATP binding site [chemical binding]; other site 1283330013606 Mg2+ binding site [ion binding]; other site 1283330013607 G-X-G motif; other site 1283330013608 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 1283330013609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330013610 active site 1283330013611 phosphorylation site [posttranslational modification] 1283330013612 intermolecular recognition site; other site 1283330013613 dimerization interface [polypeptide binding]; other site 1283330013614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1283330013615 DNA binding site [nucleotide binding] 1283330013616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1283330013617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1283330013618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1283330013619 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1283330013620 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1283330013621 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1283330013622 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1283330013623 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1283330013624 active site 1283330013625 catalytic residues [active] 1283330013626 metal binding site [ion binding]; metal-binding site 1283330013627 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1283330013628 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1283330013629 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1283330013630 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1283330013631 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1283330013632 carboxyltransferase (CT) interaction site; other site 1283330013633 biotinylation site [posttranslational modification]; other site 1283330013634 gamma-carboxygeranoyl-CoA hydratase; Validated; Region: PRK05674 1283330013635 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1283330013636 substrate binding site [chemical binding]; other site 1283330013637 oxyanion hole (OAH) forming residues; other site 1283330013638 trimer interface [polypeptide binding]; other site 1283330013639 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1283330013640 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1283330013641 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1283330013642 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1283330013643 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1283330013644 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1283330013645 substrate binding site [chemical binding]; other site 1283330013646 FAD binding site [chemical binding]; other site 1283330013647 catalytic base [active] 1283330013648 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 1283330013649 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1283330013650 DNA binding residues [nucleotide binding] 1283330013651 putative dimer interface [polypeptide binding]; other site 1283330013652 outer membrane porin, OprD family; Region: OprD; pfam03573 1283330013653 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1283330013654 Citrate transporter; Region: CitMHS; pfam03600 1283330013655 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1283330013656 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1283330013657 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1283330013658 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 1283330013659 DNA binding site [nucleotide binding] 1283330013660 DNA-binding interface [nucleotide binding]; DNA binding site 1283330013661 domain linker motif; other site 1283330013662 Integrase core domain; Region: rve; pfam00665 1283330013663 Integrase core domain; Region: rve_3; cl15866 1283330013664 transposase/IS protein; Provisional; Region: PRK09183 1283330013665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330013666 Walker A motif; other site 1283330013667 ATP binding site [chemical binding]; other site 1283330013668 Walker B motif; other site 1283330013669 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1283330013670 non-specific DNA binding site [nucleotide binding]; other site 1283330013671 salt bridge; other site 1283330013672 sequence-specific DNA binding site [nucleotide binding]; other site 1283330013673 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330013674 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330013675 Fic family protein [Function unknown]; Region: COG3177 1283330013676 Fic/DOC family; Region: Fic; pfam02661 1283330013677 Transposase domain (DUF772); Region: DUF772; pfam05598 1283330013678 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1283330013679 DDE superfamily endonuclease; Region: DDE_4; cl17710 1283330013680 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1283330013681 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 1283330013682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1283330013683 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1283330013684 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1283330013685 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1283330013686 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1283330013687 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1283330013688 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1283330013689 30S subunit binding site; other site 1283330013690 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1283330013691 DNA-binding site [nucleotide binding]; DNA binding site 1283330013692 RNA-binding motif; other site 1283330013693 H+ Antiporter protein; Region: 2A0121; TIGR00900 1283330013694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330013695 putative substrate translocation pore; other site 1283330013696 Predicted permeases [General function prediction only]; Region: COG0679 1283330013697 triosephosphate isomerase; Provisional; Region: PRK14567 1283330013698 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1283330013699 substrate binding site [chemical binding]; other site 1283330013700 dimer interface [polypeptide binding]; other site 1283330013701 catalytic triad [active] 1283330013702 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1283330013703 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1283330013704 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1283330013705 putative active site [active] 1283330013706 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1283330013707 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1283330013708 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1283330013709 tetrameric interface [polypeptide binding]; other site 1283330013710 activator binding site; other site 1283330013711 NADP binding site [chemical binding]; other site 1283330013712 substrate binding site [chemical binding]; other site 1283330013713 catalytic residues [active] 1283330013714 triosephosphate isomerase; Provisional; Region: PRK14567 1283330013715 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1283330013716 substrate binding site [chemical binding]; other site 1283330013717 dimer interface [polypeptide binding]; other site 1283330013718 catalytic triad [active] 1283330013719 enolase; Provisional; Region: eno; PRK00077 1283330013720 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1283330013721 dimer interface [polypeptide binding]; other site 1283330013722 metal binding site [ion binding]; metal-binding site 1283330013723 substrate binding pocket [chemical binding]; other site 1283330013724 pyruvate kinase; Provisional; Region: PRK05826 1283330013725 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1283330013726 domain interfaces; other site 1283330013727 active site 1283330013728 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1283330013729 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1283330013730 putative active site [active] 1283330013731 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1283330013732 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1283330013733 substrate binding site [chemical binding]; other site 1283330013734 ATP binding site [chemical binding]; other site 1283330013735 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 1283330013736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 1283330013737 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1283330013738 KduI/IolB family; Region: KduI; pfam04962 1283330013739 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1283330013740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330013741 putative substrate translocation pore; other site 1283330013742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330013743 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1283330013744 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1283330013745 tetrameric interface [polypeptide binding]; other site 1283330013746 NAD binding site [chemical binding]; other site 1283330013747 catalytic residues [active] 1283330013748 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 1283330013749 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1283330013750 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1283330013751 PYR/PP interface [polypeptide binding]; other site 1283330013752 dimer interface [polypeptide binding]; other site 1283330013753 TPP binding site [chemical binding]; other site 1283330013754 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1283330013755 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1283330013756 TPP-binding site; other site 1283330013757 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1283330013758 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283330013759 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1283330013760 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1283330013761 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1283330013762 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283330013763 putative ligand binding site [chemical binding]; other site 1283330013764 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1283330013765 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283330013766 putative ligand binding site [chemical binding]; other site 1283330013767 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1283330013768 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283330013769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330013770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330013771 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1283330013772 dimerization interface [polypeptide binding]; other site 1283330013773 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1283330013774 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1283330013775 dimer interface [polypeptide binding]; other site 1283330013776 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1283330013777 active site 1283330013778 Fe binding site [ion binding]; other site 1283330013779 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1283330013780 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1283330013781 Zn binding site [ion binding]; other site 1283330013782 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 1283330013783 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1283330013784 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1283330013785 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1283330013786 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1283330013787 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1283330013788 dimer interface [polypeptide binding]; other site 1283330013789 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1283330013790 N-terminal domain interface [polypeptide binding]; other site 1283330013791 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283330013792 trimer interface; other site 1283330013793 sugar binding site [chemical binding]; other site 1283330013794 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283330013795 DNA binding site [nucleotide binding] 1283330013796 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1283330013797 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1283330013798 putative ligand binding site [chemical binding]; other site 1283330013799 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1283330013800 active site 1283330013801 NTP binding site [chemical binding]; other site 1283330013802 metal binding triad [ion binding]; metal-binding site 1283330013803 antibiotic binding site [chemical binding]; other site 1283330013804 Uncharacterized conserved protein [Function unknown]; Region: COG2361 1283330013805 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1283330013806 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1283330013807 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283330013808 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1283330013809 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283330013810 trimer interface; other site 1283330013811 sugar binding site [chemical binding]; other site 1283330013812 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1283330013813 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1283330013814 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1283330013815 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1283330013816 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1283330013817 TM-ABC transporter signature motif; other site 1283330013818 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1283330013819 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1283330013820 Walker A/P-loop; other site 1283330013821 ATP binding site [chemical binding]; other site 1283330013822 Q-loop/lid; other site 1283330013823 ABC transporter signature motif; other site 1283330013824 Walker B; other site 1283330013825 D-loop; other site 1283330013826 H-loop/switch region; other site 1283330013827 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1283330013828 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1283330013829 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 1283330013830 putative ligand binding site [chemical binding]; other site 1283330013831 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1283330013832 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1283330013833 Walker A/P-loop; other site 1283330013834 ATP binding site [chemical binding]; other site 1283330013835 Q-loop/lid; other site 1283330013836 ABC transporter signature motif; other site 1283330013837 Walker B; other site 1283330013838 D-loop; other site 1283330013839 H-loop/switch region; other site 1283330013840 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1283330013841 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1283330013842 siderophore binding site; other site 1283330013843 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1283330013844 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1283330013845 ABC-ATPase subunit interface; other site 1283330013846 dimer interface [polypeptide binding]; other site 1283330013847 putative PBP binding regions; other site 1283330013848 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1283330013849 Condensation domain; Region: Condensation; pfam00668 1283330013850 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1283330013851 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1283330013852 MbtH-like protein; Region: MbtH; cl01279 1283330013853 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1283330013854 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1283330013855 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1283330013856 dimerization interface [polypeptide binding]; other site 1283330013857 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1283330013858 ATP binding site [chemical binding]; other site 1283330013859 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1283330013860 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1283330013861 HupF/HypC family; Region: HupF_HypC; pfam01455 1283330013862 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1283330013863 Acylphosphatase; Region: Acylphosphatase; pfam00708 1283330013864 HypF finger; Region: zf-HYPF; pfam07503 1283330013865 HypF finger; Region: zf-HYPF; pfam07503 1283330013866 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1283330013867 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1283330013868 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1283330013869 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1283330013870 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1283330013871 [NiFe] hydrogenase assembly chaperone, HybE family; Region: hydrog_HybE; TIGR03993 1283330013872 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1283330013873 Rubredoxin; Region: Rubredoxin; pfam00301 1283330013874 iron binding site [ion binding]; other site 1283330013875 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1283330013876 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1283330013877 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1283330013878 HupF/HypC family; Region: HupF_HypC; cl00394 1283330013879 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1283330013880 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1283330013881 nickel binding site [ion binding]; other site 1283330013882 putative substrate-binding site; other site 1283330013883 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 1283330013884 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1283330013885 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1283330013886 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1283330013887 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1283330013888 Helix-turn-helix domain; Region: HTH_28; pfam13518 1283330013889 Winged helix-turn helix; Region: HTH_29; pfam13551 1283330013890 Homeodomain-like domain; Region: HTH_32; pfam13565 1283330013891 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1283330013892 Integrase core domain; Region: rve; pfam00665 1283330013893 Integrase core domain; Region: rve_3; pfam13683 1283330013894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330013895 metabolite-proton symporter; Region: 2A0106; TIGR00883 1283330013896 putative substrate translocation pore; other site 1283330013897 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1283330013898 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330013899 putative active site [active] 1283330013900 heme pocket [chemical binding]; other site 1283330013901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1283330013902 dimer interface [polypeptide binding]; other site 1283330013903 phosphorylation site [posttranslational modification] 1283330013904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330013905 ATP binding site [chemical binding]; other site 1283330013906 Mg2+ binding site [ion binding]; other site 1283330013907 G-X-G motif; other site 1283330013908 Response regulator receiver domain; Region: Response_reg; pfam00072 1283330013909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330013910 active site 1283330013911 phosphorylation site [posttranslational modification] 1283330013912 intermolecular recognition site; other site 1283330013913 dimerization interface [polypeptide binding]; other site 1283330013914 Response regulator receiver domain; Region: Response_reg; pfam00072 1283330013915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330013916 active site 1283330013917 phosphorylation site [posttranslational modification] 1283330013918 intermolecular recognition site; other site 1283330013919 dimerization interface [polypeptide binding]; other site 1283330013920 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1283330013921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1283330013922 active site 1283330013923 phosphorylation site [posttranslational modification] 1283330013924 intermolecular recognition site; other site 1283330013925 dimerization interface [polypeptide binding]; other site 1283330013926 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1283330013927 Zn2+ binding site [ion binding]; other site 1283330013928 Mg2+ binding site [ion binding]; other site 1283330013929 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 1283330013930 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330013931 Walker A/P-loop; other site 1283330013932 ATP binding site [chemical binding]; other site 1283330013933 Q-loop/lid; other site 1283330013934 ABC transporter signature motif; other site 1283330013935 Walker B; other site 1283330013936 D-loop; other site 1283330013937 H-loop/switch region; other site 1283330013938 TOBE domain; Region: TOBE; pfam03459 1283330013939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330013940 putative PBP binding loops; other site 1283330013941 dimer interface [polypeptide binding]; other site 1283330013942 ABC-ATPase subunit interface; other site 1283330013943 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1283330013944 molybdenum ABC transporter, periplasmic molybdate-binding protein; Region: modA; TIGR01256 1283330013945 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1283330013946 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1283330013947 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1283330013948 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1283330013949 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1283330013950 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1283330013951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330013952 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1283330013953 Walker A/P-loop; other site 1283330013954 ATP binding site [chemical binding]; other site 1283330013955 Q-loop/lid; other site 1283330013956 ABC transporter signature motif; other site 1283330013957 Walker B; other site 1283330013958 D-loop; other site 1283330013959 H-loop/switch region; other site 1283330013960 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 1283330013961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1283330013962 dimer interface [polypeptide binding]; other site 1283330013963 conserved gate region; other site 1283330013964 putative PBP binding loops; other site 1283330013965 ABC-ATPase subunit interface; other site 1283330013966 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1283330013967 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1283330013968 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 1283330013969 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1283330013970 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 1283330013971 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1283330013972 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1283330013973 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1283330013974 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 1283330013975 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 1283330013976 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1283330013977 Protein of unknown function (DUF796); Region: DUF796; cl01226 1283330013978 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1283330013979 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1283330013980 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1283330013981 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1283330013982 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1283330013983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330013984 Walker A motif; other site 1283330013985 ATP binding site [chemical binding]; other site 1283330013986 Walker B motif; other site 1283330013987 arginine finger; other site 1283330013988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330013989 Walker A motif; other site 1283330013990 ATP binding site [chemical binding]; other site 1283330013991 Walker B motif; other site 1283330013992 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1283330013993 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1283330013994 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1283330013995 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1283330013996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1283330013997 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1283330013998 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1283330013999 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1283330014000 RnfH family Ubiquitin; Region: Ub-RnfH; pfam03658 1283330014001 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1283330014002 electron transport complex, RnfABCDGE type, G subunit; Region: rnfG; TIGR01947 1283330014003 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 1283330014004 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 1283330014005 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1283330014006 SLBB domain; Region: SLBB; pfam10531 1283330014007 electron transport complex protein RnfB; Provisional; Region: PRK05113 1283330014008 Putative Fe-S cluster; Region: FeS; cl17515 1283330014009 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1283330014010 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1283330014011 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 1283330014012 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1283330014013 putative active site [active] 1283330014014 heme pocket [chemical binding]; other site 1283330014015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1283330014016 ATP binding site [chemical binding]; other site 1283330014017 Mg2+ binding site [ion binding]; other site 1283330014018 G-X-G motif; other site 1283330014019 Nif-specific regulatory protein; Region: nifA; TIGR01817 1283330014020 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1283330014021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330014022 Walker A motif; other site 1283330014023 ATP binding site [chemical binding]; other site 1283330014024 Walker B motif; other site 1283330014025 arginine finger; other site 1283330014026 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1283330014027 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1283330014028 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1283330014029 FeS/SAM binding site; other site 1283330014030 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 1283330014031 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1283330014032 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 1283330014033 putative catalytic residues [active] 1283330014034 NifQ; Region: NifQ; pfam04891 1283330014035 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1283330014036 active site residue [active] 1283330014037 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1283330014038 putative GSH binding site [chemical binding]; other site 1283330014039 catalytic residues [active] 1283330014040 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1283330014041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1283330014042 Walker A motif; other site 1283330014043 ATP binding site [chemical binding]; other site 1283330014044 Walker B motif; other site 1283330014045 arginine finger; other site 1283330014046 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1283330014047 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1283330014048 heme-binding site [chemical binding]; other site 1283330014049 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1283330014050 FAD binding pocket [chemical binding]; other site 1283330014051 FAD binding motif [chemical binding]; other site 1283330014052 phosphate binding motif [ion binding]; other site 1283330014053 beta-alpha-beta structure motif; other site 1283330014054 NAD binding pocket [chemical binding]; other site 1283330014055 Heme binding pocket [chemical binding]; other site 1283330014056 HPP family; Region: HPP; pfam04982 1283330014057 FOG: CBS domain [General function prediction only]; Region: COG0517 1283330014058 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 1283330014059 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1283330014060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330014061 D-galactonate transporter; Region: 2A0114; TIGR00893 1283330014062 putative substrate translocation pore; other site 1283330014063 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330014064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330014065 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1283330014066 dimerization interface [polypeptide binding]; other site 1283330014067 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283330014068 Right handed beta helix region; Region: Beta_helix; pfam13229 1283330014069 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283330014070 Right handed beta helix region; Region: Beta_helix; pfam13229 1283330014071 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283330014072 Right handed beta helix region; Region: Beta_helix; pfam13229 1283330014073 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283330014074 Right handed beta helix region; Region: Beta_helix; pfam13229 1283330014075 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283330014076 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283330014077 Right handed beta helix region; Region: Beta_helix; pfam13229 1283330014078 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283330014079 Right handed beta helix region; Region: Beta_helix; pfam13229 1283330014080 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283330014081 Right handed beta helix region; Region: Beta_helix; pfam13229 1283330014082 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283330014083 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283330014084 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283330014085 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283330014086 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283330014087 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283330014088 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283330014089 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1283330014090 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1283330014091 Right handed beta helix region; Region: Beta_helix; pfam13229 1283330014092 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1283330014093 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1283330014094 putative ligand binding site [chemical binding]; other site 1283330014095 NAD binding site [chemical binding]; other site 1283330014096 catalytic site [active] 1283330014097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330014098 D-galactonate transporter; Region: 2A0114; TIGR00893 1283330014099 putative substrate translocation pore; other site 1283330014100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330014101 D-galactonate transporter; Region: 2A0114; TIGR00893 1283330014102 putative substrate translocation pore; other site 1283330014103 galactonate dehydratase; Provisional; Region: PRK14017 1283330014104 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1283330014105 putative active site pocket [active] 1283330014106 putative metal binding site [ion binding]; other site 1283330014107 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1283330014108 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1283330014109 active site 1283330014110 intersubunit interface [polypeptide binding]; other site 1283330014111 catalytic residue [active] 1283330014112 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1283330014113 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1283330014114 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1283330014115 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1283330014116 Bacterial transcriptional regulator; Region: IclR; pfam01614 1283330014117 pyruvate kinase; Provisional; Region: PRK05826 1283330014118 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1283330014119 domain interfaces; other site 1283330014120 active site 1283330014121 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283330014122 trimer interface; other site 1283330014123 sugar binding site [chemical binding]; other site 1283330014124 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1283330014125 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330014126 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1283330014127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1283330014128 Melibiase; Region: Melibiase; pfam02065 1283330014129 alpha-galactosidase; Provisional; Region: PRK15076 1283330014130 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1283330014131 NAD binding site [chemical binding]; other site 1283330014132 sugar binding site [chemical binding]; other site 1283330014133 divalent metal binding site [ion binding]; other site 1283330014134 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1283330014135 dimer interface [polypeptide binding]; other site 1283330014136 galactoside permease; Reviewed; Region: lacY; PRK09528 1283330014137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330014138 putative substrate translocation pore; other site 1283330014139 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1283330014140 classical (c) SDRs; Region: SDR_c; cd05233 1283330014141 NAD(P) binding site [chemical binding]; other site 1283330014142 active site 1283330014143 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1283330014144 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1283330014145 active site 1283330014146 catalytic residues [active] 1283330014147 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1283330014148 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1283330014149 active site 1283330014150 catalytic site [active] 1283330014151 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1283330014152 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1283330014153 putative trimer interface [polypeptide binding]; other site 1283330014154 putative CoA binding site [chemical binding]; other site 1283330014155 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283330014156 trimer interface; other site 1283330014157 sugar binding site [chemical binding]; other site 1283330014158 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1283330014159 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1283330014160 active site 1283330014161 catalytic tetrad [active] 1283330014162 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1283330014163 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1283330014164 Bacterial transcriptional regulator; Region: IclR; pfam01614 1283330014165 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1283330014166 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1283330014167 HlyD family secretion protein; Region: HlyD_3; pfam13437 1283330014168 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1283330014169 Protein export membrane protein; Region: SecD_SecF; cl14618 1283330014170 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1283330014171 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1283330014172 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1283330014173 acetyl-CoA acetyltransferase; Provisional; Region: PRK05656 1283330014174 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1283330014175 dimer interface [polypeptide binding]; other site 1283330014176 active site 1283330014177 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1283330014178 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1283330014179 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1283330014180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1283330014181 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1283330014182 putative dimerization interface [polypeptide binding]; other site 1283330014183 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1283330014184 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1283330014185 ligand binding site [chemical binding]; other site 1283330014186 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1283330014187 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1283330014188 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 1283330014189 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1283330014190 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1283330014191 metal binding site [ion binding]; metal-binding site 1283330014192 active site 1283330014193 I-site; other site 1283330014194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1283330014195 dimerization interface [polypeptide binding]; other site 1283330014196 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1283330014197 dimer interface [polypeptide binding]; other site 1283330014198 putative CheW interface [polypeptide binding]; other site 1283330014199 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1283330014200 putative active site [active] 1283330014201 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1283330014202 AAA domain; Region: AAA_30; pfam13604 1283330014203 Family description; Region: UvrD_C_2; pfam13538 1283330014204 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1283330014205 Part of AAA domain; Region: AAA_19; pfam13245 1283330014206 Family description; Region: UvrD_C_2; pfam13538 1283330014207 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1283330014208 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1283330014209 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1283330014210 Arc-like DNA binding domain; Region: Arc; pfam03869 1283330014211 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1283330014212 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1283330014213 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 1283330014214 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1283330014215 trimer interface; other site 1283330014216 sugar binding site [chemical binding]; other site 1283330014217 galactoside permease; Reviewed; Region: lacY; PRK09528 1283330014218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1283330014219 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1283330014220 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1283330014221 substrate binding [chemical binding]; other site 1283330014222 active site 1283330014223 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1283330014224 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1283330014225 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1283330014226 DNA binding site [nucleotide binding] 1283330014227 domain linker motif; other site 1283330014228 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1283330014229 putative dimerization interface [polypeptide binding]; other site 1283330014230 putative ligand binding site [chemical binding]; other site 1283330014231 Staphylococcal nuclease homologues; Region: SNc; smart00318 1283330014232 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1283330014233 Catalytic site; other site 1283330014234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1283330014235 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1283330014236 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1283330014237 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1283330014238 N-terminal domain interface [polypeptide binding]; other site 1283330014239 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 1283330014240 PLD-like domain; Region: PLDc_2; pfam13091 1283330014241 putative active site [active] 1283330014242 putative catalytic site [active] 1283330014243 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 1283330014244 PLD-like domain; Region: PLDc_2; pfam13091 1283330014245 putative active site [active] 1283330014246 putative catalytic site [active] 1283330014247 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1283330014248 active site 1283330014249 ATP binding site [chemical binding]; other site 1283330014250 substrate binding site [chemical binding]; other site 1283330014251 activation loop (A-loop); other site 1283330014252 AAA ATPase domain; Region: AAA_16; pfam13191 1283330014253 AAA domain; Region: AAA_11; pfam13086 1283330014254 Walker A motif; other site 1283330014255 ATP binding site [chemical binding]; other site 1283330014256 Walker B motif; other site 1283330014257 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1283330014258 AAA domain; Region: AAA_12; pfam13087 1283330014259 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1283330014260 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1283330014261 glutaminase active site [active] 1283330014262 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1283330014263 dimer interface [polypeptide binding]; other site 1283330014264 active site 1283330014265 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1283330014266 dimer interface [polypeptide binding]; other site 1283330014267 active site 1283330014268 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283330014269 putative DNA binding site [nucleotide binding]; other site 1283330014270 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1283330014271 putative Zn2+ binding site [ion binding]; other site 1283330014272 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1283330014273 Family description; Region: UvrD_C_2; pfam13538 1283330014274 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1283330014275 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1283330014276 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 1283330014277 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1283330014278 Substrate binding site; other site 1283330014279 Mg++ binding site; other site 1283330014280 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1283330014281 active site 1283330014282 substrate binding site [chemical binding]; other site 1283330014283 CoA binding site [chemical binding]; other site 1283330014284 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1283330014285 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330014286 N-terminal plug; other site 1283330014287 ligand-binding site [chemical binding]; other site 1283330014288 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1283330014289 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1283330014290 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1283330014291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1283330014292 dimer interface [polypeptide binding]; other site 1283330014293 conserved gate region; other site 1283330014294 putative PBP binding loops; other site 1283330014295 ABC-ATPase subunit interface; other site 1283330014296 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1283330014297 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1283330014298 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1283330014299 Walker A/P-loop; other site 1283330014300 ATP binding site [chemical binding]; other site 1283330014301 Q-loop/lid; other site 1283330014302 ABC transporter signature motif; other site 1283330014303 Walker B; other site 1283330014304 D-loop; other site 1283330014305 H-loop/switch region; other site 1283330014306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330014307 Walker A/P-loop; other site 1283330014308 ATP binding site [chemical binding]; other site 1283330014309 Q-loop/lid; other site 1283330014310 ABC transporter signature motif; other site 1283330014311 Walker B; other site 1283330014312 D-loop; other site 1283330014313 H-loop/switch region; other site 1283330014314 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1283330014315 metal ion-dependent adhesion site (MIDAS); other site 1283330014316 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1283330014317 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1283330014318 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1283330014319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1283330014320 Walker A/P-loop; other site 1283330014321 ATP binding site [chemical binding]; other site 1283330014322 Q-loop/lid; other site 1283330014323 ABC transporter signature motif; other site 1283330014324 Walker B; other site 1283330014325 D-loop; other site 1283330014326 H-loop/switch region; other site 1283330014327 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1283330014328 metal ion-dependent adhesion site (MIDAS); other site 1283330014329 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 1283330014330 Virulence factor SrfB; Region: SrfB; pfam07520 1283330014331 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1283330014332 N-terminal plug; other site 1283330014333 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1283330014334 ligand-binding site [chemical binding]; other site 1283330014335 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1283330014336 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1283330014337 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1283330014338 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1283330014339 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1283330014340 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1283330014341 gamma subunit interface [polypeptide binding]; other site 1283330014342 epsilon subunit interface [polypeptide binding]; other site 1283330014343 LBP interface [polypeptide binding]; other site 1283330014344 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1283330014345 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1283330014346 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1283330014347 alpha subunit interaction interface [polypeptide binding]; other site 1283330014348 Walker A motif; other site 1283330014349 ATP binding site [chemical binding]; other site 1283330014350 Walker B motif; other site 1283330014351 inhibitor binding site; inhibition site 1283330014352 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1283330014353 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1283330014354 core domain interface [polypeptide binding]; other site 1283330014355 delta subunit interface [polypeptide binding]; other site 1283330014356 epsilon subunit interface [polypeptide binding]; other site 1283330014357 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1283330014358 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1283330014359 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1283330014360 beta subunit interaction interface [polypeptide binding]; other site 1283330014361 Walker A motif; other site 1283330014362 ATP binding site [chemical binding]; other site 1283330014363 Walker B motif; other site 1283330014364 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1283330014365 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1283330014366 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1283330014367 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1283330014368 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1283330014369 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1283330014370 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1283330014371 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1283330014372 F0F1 ATP synthase subunit I; Validated; Region: PRK05760 1283330014373 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1283330014374 ParB-like nuclease domain; Region: ParB; smart00470 1283330014375 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1283330014376 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1283330014377 P-loop; other site 1283330014378 Magnesium ion binding site [ion binding]; other site 1283330014379 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1283330014380 Magnesium ion binding site [ion binding]; other site 1283330014381 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1283330014382 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1283330014383 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1283330014384 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1283330014385 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1283330014386 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1283330014387 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1283330014388 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1283330014389 active site 1283330014390 catalytic residues [active] 1283330014391 DNA binding site [nucleotide binding] 1283330014392 Int/Topo IB signature motif; other site 1283330014393 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1283330014394 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1283330014395 Virulence protein [General function prediction only]; Region: COG3943 1283330014396 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1283330014397 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1283330014398 DNA methylase; Region: N6_N4_Mtase; pfam01555 1283330014399 DNA methylase; Region: N6_N4_Mtase; pfam01555 1283330014400 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1283330014401 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1283330014402 ATP binding site [chemical binding]; other site 1283330014403 putative Mg++ binding site [ion binding]; other site 1283330014404 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1283330014405 nucleotide binding region [chemical binding]; other site 1283330014406 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1283330014407 ATP-binding site [chemical binding]; other site 1283330014408 Uncharacterized conserved protein [Function unknown]; Region: COG4127 1283330014409 Restriction endonuclease; Region: Mrr_cat; pfam04471 1283330014410 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1283330014411 dimerization interface [polypeptide binding]; other site 1283330014412 putative DNA binding site [nucleotide binding]; other site 1283330014413 putative Zn2+ binding site [ion binding]; other site 1283330014414 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1283330014415 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1283330014416 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1283330014417 G1 box; other site 1283330014418 GTP/Mg2+ binding site [chemical binding]; other site 1283330014419 Switch I region; other site 1283330014420 G2 box; other site 1283330014421 Switch II region; other site 1283330014422 G3 box; other site 1283330014423 G4 box; other site 1283330014424 G5 box; other site 1283330014425 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1283330014426 membrane protein insertase; Provisional; Region: PRK01318 1283330014427 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1283330014428 hypothetical protein; Provisional; Region: PRK14371 1283330014429 ribonuclease P; Reviewed; Region: rnpA; PRK00396 1283330014430 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399