-- dump date 20140618_222717 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1127744000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1127744000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1127744000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744000004 Walker A motif; other site 1127744000005 ATP binding site [chemical binding]; other site 1127744000006 Walker B motif; other site 1127744000007 arginine finger; other site 1127744000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1127744000009 DnaA box-binding interface [nucleotide binding]; other site 1127744000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1127744000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1127744000012 putative DNA binding surface [nucleotide binding]; other site 1127744000013 dimer interface [polypeptide binding]; other site 1127744000014 beta-clamp/clamp loader binding surface; other site 1127744000015 beta-clamp/translesion DNA polymerase binding surface; other site 1127744000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1127744000017 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 1127744000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1127744000019 Walker A/P-loop; other site 1127744000020 ATP binding site [chemical binding]; other site 1127744000021 Q-loop/lid; other site 1127744000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1127744000023 ABC transporter signature motif; other site 1127744000024 Walker B; other site 1127744000025 D-loop; other site 1127744000026 H-loop/switch region; other site 1127744000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1127744000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744000029 ATP binding site [chemical binding]; other site 1127744000030 Mg2+ binding site [ion binding]; other site 1127744000031 G-X-G motif; other site 1127744000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1127744000033 anchoring element; other site 1127744000034 dimer interface [polypeptide binding]; other site 1127744000035 ATP binding site [chemical binding]; other site 1127744000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1127744000037 active site 1127744000038 putative metal-binding site [ion binding]; other site 1127744000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1127744000040 DNA gyrase subunit A; Validated; Region: PRK05560 1127744000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1127744000042 CAP-like domain; other site 1127744000043 active site 1127744000044 primary dimer interface [polypeptide binding]; other site 1127744000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127744000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127744000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127744000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127744000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127744000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127744000051 YaaC-like Protein; Region: YaaC; pfam14175 1127744000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1127744000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1127744000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1127744000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1127744000056 active site 1127744000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1127744000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1127744000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1127744000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1127744000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1127744000062 active site 1127744000063 multimer interface [polypeptide binding]; other site 1127744000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1127744000065 predicted active site [active] 1127744000066 catalytic triad [active] 1127744000067 seryl-tRNA synthetase; Provisional; Region: PRK05431 1127744000068 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1127744000069 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1127744000070 dimer interface [polypeptide binding]; other site 1127744000071 active site 1127744000072 motif 1; other site 1127744000073 motif 2; other site 1127744000074 motif 3; other site 1127744000075 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1127744000076 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1127744000077 Substrate-binding site [chemical binding]; other site 1127744000078 Substrate specificity [chemical binding]; other site 1127744000079 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1127744000080 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1127744000081 Substrate-binding site [chemical binding]; other site 1127744000082 Substrate specificity [chemical binding]; other site 1127744000083 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1127744000084 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744000085 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1127744000086 active site 1127744000087 Isochorismatase family; Region: Isochorismatase; pfam00857 1127744000088 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1127744000089 catalytic triad [active] 1127744000090 conserved cis-peptide bond; other site 1127744000091 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1127744000092 nucleoside/Zn binding site; other site 1127744000093 dimer interface [polypeptide binding]; other site 1127744000094 catalytic motif [active] 1127744000095 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1127744000096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744000097 Walker A motif; other site 1127744000098 ATP binding site [chemical binding]; other site 1127744000099 Walker B motif; other site 1127744000100 arginine finger; other site 1127744000101 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1127744000102 hypothetical protein; Validated; Region: PRK00153 1127744000103 recombination protein RecR; Reviewed; Region: recR; PRK00076 1127744000104 RecR protein; Region: RecR; pfam02132 1127744000105 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1127744000106 putative active site [active] 1127744000107 putative metal-binding site [ion binding]; other site 1127744000108 tetramer interface [polypeptide binding]; other site 1127744000109 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1127744000110 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 1127744000111 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1127744000112 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1127744000113 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1127744000114 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 1127744000115 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1127744000116 homodimer interface [polypeptide binding]; other site 1127744000117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744000118 catalytic residue [active] 1127744000119 thymidylate kinase; Validated; Region: tmk; PRK00698 1127744000120 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1127744000121 TMP-binding site; other site 1127744000122 ATP-binding site [chemical binding]; other site 1127744000123 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1127744000124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1728 1127744000125 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1127744000126 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1127744000127 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1127744000128 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1127744000129 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1127744000130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744000131 S-adenosylmethionine binding site [chemical binding]; other site 1127744000132 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1127744000133 GIY-YIG motif/motif A; other site 1127744000134 putative active site [active] 1127744000135 putative metal binding site [ion binding]; other site 1127744000136 Predicted methyltransferases [General function prediction only]; Region: COG0313 1127744000137 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1127744000138 putative SAM binding site [chemical binding]; other site 1127744000139 putative homodimer interface [polypeptide binding]; other site 1127744000140 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1127744000141 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1127744000142 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1127744000143 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1127744000144 active site 1127744000145 HIGH motif; other site 1127744000146 KMSKS motif; other site 1127744000147 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1127744000148 tRNA binding surface [nucleotide binding]; other site 1127744000149 anticodon binding site; other site 1127744000150 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1127744000151 dimer interface [polypeptide binding]; other site 1127744000152 putative tRNA-binding site [nucleotide binding]; other site 1127744000153 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1127744000154 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1127744000155 active site 1127744000156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1127744000157 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1127744000158 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1127744000159 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1127744000160 G5 domain; Region: G5; pfam07501 1127744000161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1127744000162 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1127744000163 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1127744000164 putative active site [active] 1127744000165 putative metal binding site [ion binding]; other site 1127744000166 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1127744000167 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1127744000168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744000169 S-adenosylmethionine binding site [chemical binding]; other site 1127744000170 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1127744000171 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1127744000172 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1127744000173 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1127744000174 pur operon repressor; Provisional; Region: PRK09213 1127744000175 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1127744000176 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127744000177 active site 1127744000178 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1127744000179 homotrimer interaction site [polypeptide binding]; other site 1127744000180 putative active site [active] 1127744000181 regulatory protein SpoVG; Reviewed; Region: PRK13259 1127744000182 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1127744000183 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1127744000184 Substrate binding site; other site 1127744000185 Mg++ binding site; other site 1127744000186 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1127744000187 active site 1127744000188 substrate binding site [chemical binding]; other site 1127744000189 CoA binding site [chemical binding]; other site 1127744000190 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1127744000191 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1127744000192 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127744000193 active site 1127744000194 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1127744000195 putative active site [active] 1127744000196 catalytic residue [active] 1127744000197 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1127744000198 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1127744000199 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1127744000200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127744000201 ATP binding site [chemical binding]; other site 1127744000202 putative Mg++ binding site [ion binding]; other site 1127744000203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127744000204 nucleotide binding region [chemical binding]; other site 1127744000205 ATP-binding site [chemical binding]; other site 1127744000206 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1127744000207 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1127744000208 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1127744000209 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1127744000210 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1127744000211 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1127744000212 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1127744000213 putative SAM binding site [chemical binding]; other site 1127744000214 putative homodimer interface [polypeptide binding]; other site 1127744000215 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1127744000216 homodimer interface [polypeptide binding]; other site 1127744000217 metal binding site [ion binding]; metal-binding site 1127744000218 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1127744000219 homodimer interface [polypeptide binding]; other site 1127744000220 active site 1127744000221 putative chemical substrate binding site [chemical binding]; other site 1127744000222 metal binding site [ion binding]; metal-binding site 1127744000223 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127744000224 RNA binding surface [nucleotide binding]; other site 1127744000225 sporulation protein YabP; Region: spore_yabP; TIGR02892 1127744000226 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1127744000227 hypothetical protein; Provisional; Region: PRK08582 1127744000228 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1127744000229 RNA binding site [nucleotide binding]; other site 1127744000230 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1127744000231 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1127744000232 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1127744000233 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1127744000234 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1127744000235 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1127744000236 metal ion-dependent adhesion site (MIDAS); other site 1127744000237 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1127744000238 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127744000239 active site 1127744000240 ATP binding site [chemical binding]; other site 1127744000241 substrate binding site [chemical binding]; other site 1127744000242 activation loop (A-loop); other site 1127744000243 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127744000244 active site 1127744000245 FtsH Extracellular; Region: FtsH_ext; pfam06480 1127744000246 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1127744000247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744000248 Walker A motif; other site 1127744000249 ATP binding site [chemical binding]; other site 1127744000250 Walker B motif; other site 1127744000251 arginine finger; other site 1127744000252 Peptidase family M41; Region: Peptidase_M41; pfam01434 1127744000253 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1127744000254 nucleotide binding site [chemical binding]; other site 1127744000255 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1127744000256 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1127744000257 dimerization interface [polypeptide binding]; other site 1127744000258 domain crossover interface; other site 1127744000259 redox-dependent activation switch; other site 1127744000260 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1127744000261 SurA N-terminal domain; Region: SurA_N_3; cl07813 1127744000262 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1127744000263 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1127744000264 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1127744000265 dimer interface [polypeptide binding]; other site 1127744000266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744000267 catalytic residue [active] 1127744000268 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1127744000269 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1127744000270 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1127744000271 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1127744000272 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1127744000273 glutamine binding [chemical binding]; other site 1127744000274 catalytic triad [active] 1127744000275 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1127744000276 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1127744000277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744000278 catalytic residue [active] 1127744000279 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1127744000280 dihydropteroate synthase; Region: DHPS; TIGR01496 1127744000281 substrate binding pocket [chemical binding]; other site 1127744000282 dimer interface [polypeptide binding]; other site 1127744000283 inhibitor binding site; inhibition site 1127744000284 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1127744000285 homooctamer interface [polypeptide binding]; other site 1127744000286 active site 1127744000287 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1127744000288 catalytic center binding site [active] 1127744000289 ATP binding site [chemical binding]; other site 1127744000290 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127744000291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127744000292 non-specific DNA binding site [nucleotide binding]; other site 1127744000293 salt bridge; other site 1127744000294 sequence-specific DNA binding site [nucleotide binding]; other site 1127744000295 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1127744000296 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1127744000297 FMN binding site [chemical binding]; other site 1127744000298 active site 1127744000299 catalytic residues [active] 1127744000300 substrate binding site [chemical binding]; other site 1127744000301 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1127744000302 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1127744000303 dimer interface [polypeptide binding]; other site 1127744000304 putative anticodon binding site; other site 1127744000305 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1127744000306 motif 1; other site 1127744000307 active site 1127744000308 motif 2; other site 1127744000309 motif 3; other site 1127744000310 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1127744000311 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1127744000312 UvrB/uvrC motif; Region: UVR; pfam02151 1127744000313 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1127744000314 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1127744000315 ADP binding site [chemical binding]; other site 1127744000316 phosphagen binding site; other site 1127744000317 substrate specificity loop; other site 1127744000318 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1127744000319 Clp amino terminal domain; Region: Clp_N; pfam02861 1127744000320 Clp amino terminal domain; Region: Clp_N; pfam02861 1127744000321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744000322 Walker A motif; other site 1127744000323 ATP binding site [chemical binding]; other site 1127744000324 Walker B motif; other site 1127744000325 arginine finger; other site 1127744000326 UvrB/uvrC motif; Region: UVR; pfam02151 1127744000327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744000328 Walker A motif; other site 1127744000329 ATP binding site [chemical binding]; other site 1127744000330 Walker B motif; other site 1127744000331 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1127744000332 DNA repair protein RadA; Provisional; Region: PRK11823 1127744000333 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1127744000334 Walker A motif/ATP binding site; other site 1127744000335 ATP binding site [chemical binding]; other site 1127744000336 Walker B motif; other site 1127744000337 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1127744000338 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1127744000339 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1127744000340 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1127744000341 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1127744000342 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1127744000343 putative active site [active] 1127744000344 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1127744000345 substrate binding site; other site 1127744000346 dimer interface; other site 1127744000347 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1127744000348 homotrimer interaction site [polypeptide binding]; other site 1127744000349 zinc binding site [ion binding]; other site 1127744000350 CDP-binding sites; other site 1127744000351 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1127744000352 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1127744000353 active site 1127744000354 HIGH motif; other site 1127744000355 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1127744000356 active site 1127744000357 KMSKS motif; other site 1127744000358 serine O-acetyltransferase; Region: cysE; TIGR01172 1127744000359 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1127744000360 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1127744000361 trimer interface [polypeptide binding]; other site 1127744000362 active site 1127744000363 substrate binding site [chemical binding]; other site 1127744000364 CoA binding site [chemical binding]; other site 1127744000365 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1127744000366 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1127744000367 active site 1127744000368 HIGH motif; other site 1127744000369 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1127744000370 KMSKS motif; other site 1127744000371 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1127744000372 tRNA binding surface [nucleotide binding]; other site 1127744000373 anticodon binding site; other site 1127744000374 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1127744000375 active site 1127744000376 metal binding site [ion binding]; metal-binding site 1127744000377 dimerization interface [polypeptide binding]; other site 1127744000378 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1127744000379 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1127744000380 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1127744000381 YacP-like NYN domain; Region: NYN_YacP; cl01491 1127744000382 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1127744000383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744000384 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1127744000385 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1127744000386 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1127744000387 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1127744000388 putative homodimer interface [polypeptide binding]; other site 1127744000389 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1127744000390 heterodimer interface [polypeptide binding]; other site 1127744000391 homodimer interface [polypeptide binding]; other site 1127744000392 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1127744000393 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1127744000394 23S rRNA interface [nucleotide binding]; other site 1127744000395 L7/L12 interface [polypeptide binding]; other site 1127744000396 putative thiostrepton binding site; other site 1127744000397 L25 interface [polypeptide binding]; other site 1127744000398 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1127744000399 mRNA/rRNA interface [nucleotide binding]; other site 1127744000400 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1127744000401 23S rRNA interface [nucleotide binding]; other site 1127744000402 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1127744000403 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1127744000404 core dimer interface [polypeptide binding]; other site 1127744000405 peripheral dimer interface [polypeptide binding]; other site 1127744000406 L10 interface [polypeptide binding]; other site 1127744000407 L11 interface [polypeptide binding]; other site 1127744000408 putative EF-Tu interaction site [polypeptide binding]; other site 1127744000409 putative EF-G interaction site [polypeptide binding]; other site 1127744000410 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1127744000411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744000412 S-adenosylmethionine binding site [chemical binding]; other site 1127744000413 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1127744000414 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1127744000415 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1127744000416 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1127744000417 RPB1 interaction site [polypeptide binding]; other site 1127744000418 RPB10 interaction site [polypeptide binding]; other site 1127744000419 RPB11 interaction site [polypeptide binding]; other site 1127744000420 RPB3 interaction site [polypeptide binding]; other site 1127744000421 RPB12 interaction site [polypeptide binding]; other site 1127744000422 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1127744000423 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1127744000424 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1127744000425 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1127744000426 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1127744000427 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1127744000428 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1127744000429 G-loop; other site 1127744000430 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1127744000431 DNA binding site [nucleotide binding] 1127744000432 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1127744000433 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1127744000434 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1127744000435 S17 interaction site [polypeptide binding]; other site 1127744000436 S8 interaction site; other site 1127744000437 16S rRNA interaction site [nucleotide binding]; other site 1127744000438 streptomycin interaction site [chemical binding]; other site 1127744000439 23S rRNA interaction site [nucleotide binding]; other site 1127744000440 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1127744000441 30S ribosomal protein S7; Validated; Region: PRK05302 1127744000442 elongation factor G; Reviewed; Region: PRK00007 1127744000443 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1127744000444 G1 box; other site 1127744000445 putative GEF interaction site [polypeptide binding]; other site 1127744000446 GTP/Mg2+ binding site [chemical binding]; other site 1127744000447 Switch I region; other site 1127744000448 G2 box; other site 1127744000449 G3 box; other site 1127744000450 Switch II region; other site 1127744000451 G4 box; other site 1127744000452 G5 box; other site 1127744000453 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1127744000454 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1127744000455 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1127744000456 elongation factor Tu; Reviewed; Region: PRK00049 1127744000457 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1127744000458 G1 box; other site 1127744000459 GEF interaction site [polypeptide binding]; other site 1127744000460 GTP/Mg2+ binding site [chemical binding]; other site 1127744000461 Switch I region; other site 1127744000462 G2 box; other site 1127744000463 G3 box; other site 1127744000464 Switch II region; other site 1127744000465 G4 box; other site 1127744000466 G5 box; other site 1127744000467 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1127744000468 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1127744000469 Antibiotic Binding Site [chemical binding]; other site 1127744000470 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1127744000471 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1127744000472 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1127744000473 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1127744000474 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1127744000475 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1127744000476 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1127744000477 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1127744000478 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1127744000479 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1127744000480 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1127744000481 putative translocon binding site; other site 1127744000482 protein-rRNA interface [nucleotide binding]; other site 1127744000483 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1127744000484 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1127744000485 G-X-X-G motif; other site 1127744000486 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1127744000487 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1127744000488 23S rRNA interface [nucleotide binding]; other site 1127744000489 5S rRNA interface [nucleotide binding]; other site 1127744000490 putative antibiotic binding site [chemical binding]; other site 1127744000491 L25 interface [polypeptide binding]; other site 1127744000492 L27 interface [polypeptide binding]; other site 1127744000493 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1127744000494 23S rRNA interface [nucleotide binding]; other site 1127744000495 putative translocon interaction site; other site 1127744000496 signal recognition particle (SRP54) interaction site; other site 1127744000497 L23 interface [polypeptide binding]; other site 1127744000498 trigger factor interaction site; other site 1127744000499 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1127744000500 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1127744000501 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1127744000502 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1127744000503 RNA binding site [nucleotide binding]; other site 1127744000504 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1127744000505 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1127744000506 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1127744000507 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1127744000508 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1127744000509 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1127744000510 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1127744000511 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1127744000512 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1127744000513 5S rRNA interface [nucleotide binding]; other site 1127744000514 L27 interface [polypeptide binding]; other site 1127744000515 23S rRNA interface [nucleotide binding]; other site 1127744000516 L5 interface [polypeptide binding]; other site 1127744000517 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1127744000518 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1127744000519 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1127744000520 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1127744000521 23S rRNA binding site [nucleotide binding]; other site 1127744000522 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1127744000523 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1127744000524 SecY translocase; Region: SecY; pfam00344 1127744000525 adenylate kinase; Reviewed; Region: adk; PRK00279 1127744000526 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1127744000527 AMP-binding site [chemical binding]; other site 1127744000528 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1127744000529 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1127744000530 active site 1127744000531 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 1127744000532 RNA binding site [nucleotide binding]; other site 1127744000533 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1127744000534 rRNA binding site [nucleotide binding]; other site 1127744000535 predicted 30S ribosome binding site; other site 1127744000536 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1127744000537 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1127744000538 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1127744000539 30S ribosomal protein S11; Validated; Region: PRK05309 1127744000540 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1127744000541 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1127744000542 alphaNTD homodimer interface [polypeptide binding]; other site 1127744000543 alphaNTD - beta interaction site [polypeptide binding]; other site 1127744000544 alphaNTD - beta' interaction site [polypeptide binding]; other site 1127744000545 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1127744000546 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1127744000547 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1127744000548 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1127744000549 Walker A/P-loop; other site 1127744000550 ATP binding site [chemical binding]; other site 1127744000551 Q-loop/lid; other site 1127744000552 ABC transporter signature motif; other site 1127744000553 Walker B; other site 1127744000554 D-loop; other site 1127744000555 H-loop/switch region; other site 1127744000556 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1127744000557 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1127744000558 Walker A/P-loop; other site 1127744000559 ATP binding site [chemical binding]; other site 1127744000560 Q-loop/lid; other site 1127744000561 ABC transporter signature motif; other site 1127744000562 Walker B; other site 1127744000563 D-loop; other site 1127744000564 H-loop/switch region; other site 1127744000565 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1127744000566 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1127744000567 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1127744000568 dimerization interface 3.5A [polypeptide binding]; other site 1127744000569 active site 1127744000570 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1127744000571 23S rRNA interface [nucleotide binding]; other site 1127744000572 L3 interface [polypeptide binding]; other site 1127744000573 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1127744000574 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1127744000575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744000576 S-adenosylmethionine binding site [chemical binding]; other site 1127744000577 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1127744000578 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1127744000579 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1127744000580 active site 1127744000581 metal binding site [ion binding]; metal-binding site 1127744000582 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1127744000583 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1127744000584 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1127744000585 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1127744000586 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 1127744000587 NodB motif; other site 1127744000588 putative active site [active] 1127744000589 putative catalytic site [active] 1127744000590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744000591 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744000592 putative substrate translocation pore; other site 1127744000593 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1127744000594 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127744000595 inhibitor-cofactor binding pocket; inhibition site 1127744000596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744000597 catalytic residue [active] 1127744000598 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1127744000599 active site 1127744000600 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1127744000601 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1127744000602 NAD(P) binding site [chemical binding]; other site 1127744000603 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1127744000604 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1127744000605 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1127744000606 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1127744000607 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1127744000608 Sodium Bile acid symporter family; Region: SBF; cl17470 1127744000609 Sodium Bile acid symporter family; Region: SBF; cl17470 1127744000610 Putative esterase; Region: Esterase; pfam00756 1127744000611 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1127744000612 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1127744000613 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127744000614 dimer interface [polypeptide binding]; other site 1127744000615 putative PBP binding regions; other site 1127744000616 ABC-ATPase subunit interface; other site 1127744000617 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1127744000618 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1127744000619 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127744000620 ABC-ATPase subunit interface; other site 1127744000621 dimer interface [polypeptide binding]; other site 1127744000622 putative PBP binding regions; other site 1127744000623 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1127744000624 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1127744000625 putative ligand binding residues [chemical binding]; other site 1127744000626 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127744000627 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127744000628 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1127744000629 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1127744000630 putative ligand binding residues [chemical binding]; other site 1127744000631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 1127744000632 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1127744000633 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1127744000634 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1127744000635 putative periplasmic esterase; Provisional; Region: PRK03642 1127744000636 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1127744000637 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1127744000638 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1127744000639 active site turn [active] 1127744000640 phosphorylation site [posttranslational modification] 1127744000641 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1127744000642 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1127744000643 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1127744000644 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1127744000645 putative active site [active] 1127744000646 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1127744000647 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1127744000648 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1127744000649 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744000650 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744000651 DNA binding residues [nucleotide binding] 1127744000652 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1127744000653 Putative zinc-finger; Region: zf-HC2; pfam13490 1127744000654 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1127744000655 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1127744000656 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1127744000657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1127744000658 YbbR-like protein; Region: YbbR; pfam07949 1127744000659 YbbR-like protein; Region: YbbR; pfam07949 1127744000660 YbbR-like protein; Region: YbbR; pfam07949 1127744000661 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1127744000662 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1127744000663 active site 1127744000664 substrate binding site [chemical binding]; other site 1127744000665 metal binding site [ion binding]; metal-binding site 1127744000666 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1127744000667 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1127744000668 glutaminase active site [active] 1127744000669 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1127744000670 dimer interface [polypeptide binding]; other site 1127744000671 active site 1127744000672 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1127744000673 dimer interface [polypeptide binding]; other site 1127744000674 active site 1127744000675 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1127744000676 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 1127744000677 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1127744000678 minor groove reading motif; other site 1127744000679 helix-hairpin-helix signature motif; other site 1127744000680 substrate binding pocket [chemical binding]; other site 1127744000681 active site 1127744000682 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1127744000683 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1127744000684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127744000685 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127744000686 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1127744000687 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1127744000688 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1127744000689 DNA binding site [nucleotide binding] 1127744000690 active site 1127744000691 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1127744000692 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1127744000693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1127744000694 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1127744000695 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: CynT; COG0288 1127744000696 zinc binding site [ion binding]; other site 1127744000697 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1127744000698 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127744000699 dimerization interface [polypeptide binding]; other site 1127744000700 putative DNA binding site [nucleotide binding]; other site 1127744000701 putative Zn2+ binding site [ion binding]; other site 1127744000702 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1127744000703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744000704 putative substrate translocation pore; other site 1127744000705 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1127744000706 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1127744000707 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1127744000708 DNA binding residues [nucleotide binding] 1127744000709 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1127744000710 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127744000711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744000712 active site 1127744000713 phosphorylation site [posttranslational modification] 1127744000714 intermolecular recognition site; other site 1127744000715 dimerization interface [polypeptide binding]; other site 1127744000716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127744000717 DNA binding site [nucleotide binding] 1127744000718 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1127744000719 dimerization interface [polypeptide binding]; other site 1127744000720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1127744000721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1127744000722 phosphorylation site [posttranslational modification] 1127744000723 dimer interface [polypeptide binding]; other site 1127744000724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744000725 ATP binding site [chemical binding]; other site 1127744000726 Mg2+ binding site [ion binding]; other site 1127744000727 G-X-G motif; other site 1127744000728 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127744000729 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1127744000730 active site 1127744000731 ATP binding site [chemical binding]; other site 1127744000732 substrate binding site [chemical binding]; other site 1127744000733 activation loop (A-loop); other site 1127744000734 putative transport protein YifK; Provisional; Region: PRK10746 1127744000735 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1127744000736 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1127744000737 Cytochrome P450; Region: p450; cl12078 1127744000738 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1127744000739 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1127744000740 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1127744000741 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1127744000742 PhoU domain; Region: PhoU; pfam01895 1127744000743 PhoU domain; Region: PhoU; pfam01895 1127744000744 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1127744000745 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1127744000746 active site 1127744000747 catalytic site [active] 1127744000748 metal binding site [ion binding]; metal-binding site 1127744000749 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1127744000750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744000751 putative substrate translocation pore; other site 1127744000752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744000753 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1127744000754 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744000755 MarR family; Region: MarR; pfam01047 1127744000756 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1127744000757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744000758 Coenzyme A binding pocket [chemical binding]; other site 1127744000759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744000760 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744000761 putative substrate translocation pore; other site 1127744000762 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1127744000763 EamA-like transporter family; Region: EamA; pfam00892 1127744000764 EamA-like transporter family; Region: EamA; pfam00892 1127744000765 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1127744000766 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127744000767 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127744000768 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127744000769 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1127744000770 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127744000771 ATP-grasp domain; Region: ATP-grasp; pfam02222 1127744000772 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1127744000773 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1127744000774 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1127744000775 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1127744000776 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1127744000777 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1127744000778 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1127744000779 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1127744000780 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1127744000781 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1127744000782 active site residue [active] 1127744000783 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1127744000784 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1127744000785 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1127744000786 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1127744000787 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1127744000788 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1127744000789 active site turn [active] 1127744000790 phosphorylation site [posttranslational modification] 1127744000791 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1127744000792 HPr interaction site; other site 1127744000793 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1127744000794 active site 1127744000795 phosphorylation site [posttranslational modification] 1127744000796 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1127744000797 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1127744000798 active site 1127744000799 trimer interface [polypeptide binding]; other site 1127744000800 allosteric site; other site 1127744000801 active site lid [active] 1127744000802 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1127744000803 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1127744000804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744000805 DNA-binding site [nucleotide binding]; DNA binding site 1127744000806 UTRA domain; Region: UTRA; pfam07702 1127744000807 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1127744000808 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1127744000809 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1127744000810 homodimer interface [polypeptide binding]; other site 1127744000811 substrate-cofactor binding pocket; other site 1127744000812 catalytic residue [active] 1127744000813 S-methylmethionine transporter; Provisional; Region: PRK11387 1127744000814 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1127744000815 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1127744000816 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1127744000817 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1127744000818 glutaminase; Reviewed; Region: PRK12357 1127744000819 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1127744000820 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1127744000821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744000822 ATP binding site [chemical binding]; other site 1127744000823 Mg2+ binding site [ion binding]; other site 1127744000824 G-X-G motif; other site 1127744000825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744000826 Response regulator receiver domain; Region: Response_reg; pfam00072 1127744000827 active site 1127744000828 phosphorylation site [posttranslational modification] 1127744000829 intermolecular recognition site; other site 1127744000830 dimerization interface [polypeptide binding]; other site 1127744000831 YcbB domain; Region: YcbB; pfam08664 1127744000832 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1127744000833 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127744000834 NAD(P) binding site [chemical binding]; other site 1127744000835 catalytic residues [active] 1127744000836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744000837 D-galactonate transporter; Region: 2A0114; TIGR00893 1127744000838 putative substrate translocation pore; other site 1127744000839 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1127744000840 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1127744000841 active site 1127744000842 tetramer interface [polypeptide binding]; other site 1127744000843 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1127744000844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744000845 DNA-binding site [nucleotide binding]; DNA binding site 1127744000846 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1127744000847 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1127744000848 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1127744000849 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1127744000850 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1127744000851 putative active site [active] 1127744000852 putative substrate binding site [chemical binding]; other site 1127744000853 Phosphotransferase enzyme family; Region: APH; pfam01636 1127744000854 ATP binding site [chemical binding]; other site 1127744000855 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1127744000856 dodecamer interface 1 [polypeptide binding]; other site 1127744000857 dodecamer interface 2 [polypeptide binding]; other site 1127744000858 trimer interface [polypeptide binding]; other site 1127744000859 TRAP binding interface [polypeptide binding]; other site 1127744000860 Zn binding site [ion binding]; other site 1127744000861 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1127744000862 EamA-like transporter family; Region: EamA; pfam00892 1127744000863 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127744000864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744000865 active site 1127744000866 phosphorylation site [posttranslational modification] 1127744000867 intermolecular recognition site; other site 1127744000868 dimerization interface [polypeptide binding]; other site 1127744000869 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127744000870 DNA binding site [nucleotide binding] 1127744000871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1127744000872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744000873 dimer interface [polypeptide binding]; other site 1127744000874 phosphorylation site [posttranslational modification] 1127744000875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744000876 ATP binding site [chemical binding]; other site 1127744000877 Mg2+ binding site [ion binding]; other site 1127744000878 G-X-G motif; other site 1127744000879 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1127744000880 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1127744000881 Walker A/P-loop; other site 1127744000882 ATP binding site [chemical binding]; other site 1127744000883 Q-loop/lid; other site 1127744000884 ABC transporter signature motif; other site 1127744000885 Walker B; other site 1127744000886 D-loop; other site 1127744000887 H-loop/switch region; other site 1127744000888 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1127744000889 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1127744000890 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1127744000891 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1127744000892 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1127744000893 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1127744000894 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1127744000895 putative active site [active] 1127744000896 putative metal binding site [ion binding]; other site 1127744000897 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1127744000898 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1127744000899 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1127744000900 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1127744000901 putative substrate binding pocket [chemical binding]; other site 1127744000902 AC domain interface; other site 1127744000903 catalytic triad [active] 1127744000904 AB domain interface; other site 1127744000905 interchain disulfide; other site 1127744000906 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1127744000907 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1127744000908 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127744000909 catalytic residue [active] 1127744000910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744000911 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744000912 putative substrate translocation pore; other site 1127744000913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744000914 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744000915 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744000916 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1127744000917 active site 1127744000918 homotetramer interface [polypeptide binding]; other site 1127744000919 homodimer interface [polypeptide binding]; other site 1127744000920 Lipase (class 2); Region: Lipase_2; pfam01674 1127744000921 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127744000922 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1127744000923 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1127744000924 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1127744000925 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1127744000926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744000927 ATP binding site [chemical binding]; other site 1127744000928 Mg2+ binding site [ion binding]; other site 1127744000929 G-X-G motif; other site 1127744000930 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1127744000931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744000932 active site 1127744000933 phosphorylation site [posttranslational modification] 1127744000934 intermolecular recognition site; other site 1127744000935 dimerization interface [polypeptide binding]; other site 1127744000936 LytTr DNA-binding domain; Region: LytTR; pfam04397 1127744000937 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1127744000938 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 1127744000939 Walker A/P-loop; other site 1127744000940 ATP binding site [chemical binding]; other site 1127744000941 Q-loop/lid; other site 1127744000942 ABC transporter signature motif; other site 1127744000943 Walker B; other site 1127744000944 D-loop; other site 1127744000945 H-loop/switch region; other site 1127744000946 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1127744000947 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1127744000948 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1127744000949 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1127744000950 active site 1127744000951 catalytic tetrad [active] 1127744000952 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1127744000953 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1127744000954 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1127744000955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744000956 binding surface 1127744000957 TPR motif; other site 1127744000958 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744000959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744000960 binding surface 1127744000961 TPR motif; other site 1127744000962 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1127744000963 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1127744000964 NAD binding site [chemical binding]; other site 1127744000965 homodimer interface [polypeptide binding]; other site 1127744000966 active site 1127744000967 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1127744000968 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1127744000969 Ca binding site [ion binding]; other site 1127744000970 active site 1127744000971 catalytic site [active] 1127744000972 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1127744000973 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1127744000974 metal binding site [ion binding]; metal-binding site 1127744000975 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1127744000976 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1127744000977 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1127744000978 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127744000979 ABC-ATPase subunit interface; other site 1127744000980 dimer interface [polypeptide binding]; other site 1127744000981 putative PBP binding regions; other site 1127744000982 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1127744000983 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1127744000984 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1127744000985 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1127744000986 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127744000987 putative metal binding site [ion binding]; other site 1127744000988 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1127744000989 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127744000990 putative metal binding site [ion binding]; other site 1127744000991 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1127744000992 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1127744000993 putative metal binding site [ion binding]; other site 1127744000994 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1127744000995 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1127744000996 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 1127744000997 benzoate transport; Region: 2A0115; TIGR00895 1127744000998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744000999 putative substrate translocation pore; other site 1127744001000 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1127744001001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744001002 putative substrate translocation pore; other site 1127744001003 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127744001004 dimerization interface [polypeptide binding]; other site 1127744001005 putative DNA binding site [nucleotide binding]; other site 1127744001006 putative Zn2+ binding site [ion binding]; other site 1127744001007 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1127744001008 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1127744001009 Walker A/P-loop; other site 1127744001010 ATP binding site [chemical binding]; other site 1127744001011 Q-loop/lid; other site 1127744001012 ABC transporter signature motif; other site 1127744001013 Walker B; other site 1127744001014 D-loop; other site 1127744001015 H-loop/switch region; other site 1127744001016 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1127744001017 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1127744001018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744001019 dimer interface [polypeptide binding]; other site 1127744001020 conserved gate region; other site 1127744001021 putative PBP binding loops; other site 1127744001022 ABC-ATPase subunit interface; other site 1127744001023 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1127744001024 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1127744001025 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1127744001026 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1127744001027 amidohydrolase; Region: amidohydrolases; TIGR01891 1127744001028 metal binding site [ion binding]; metal-binding site 1127744001029 putative dimer interface [polypeptide binding]; other site 1127744001030 Predicted membrane protein [Function unknown]; Region: COG1288 1127744001031 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1127744001032 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1127744001033 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1127744001034 active site 1127744001035 Ca binding site [ion binding]; other site 1127744001036 catalytic site [active] 1127744001037 Aamy_C domain; Region: Aamy_C; smart00632 1127744001038 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1127744001039 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1127744001040 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1127744001041 NAD binding site [chemical binding]; other site 1127744001042 dimer interface [polypeptide binding]; other site 1127744001043 substrate binding site [chemical binding]; other site 1127744001044 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1127744001045 L-lactate permease; Region: Lactate_perm; pfam02652 1127744001046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744001047 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744001048 putative substrate translocation pore; other site 1127744001049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744001050 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744001051 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127744001052 putative DNA binding site [nucleotide binding]; other site 1127744001053 putative Zn2+ binding site [ion binding]; other site 1127744001054 LysE type translocator; Region: LysE; pfam01810 1127744001055 Uncharacterized conserved protein [Function unknown]; Region: COG3403 1127744001056 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1127744001057 Spore germination protein; Region: Spore_permease; cl17796 1127744001058 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1127744001059 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1127744001060 NAD+ synthetase; Region: nadE; TIGR00552 1127744001061 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1127744001062 homodimer interface [polypeptide binding]; other site 1127744001063 NAD binding pocket [chemical binding]; other site 1127744001064 ATP binding pocket [chemical binding]; other site 1127744001065 Mg binding site [ion binding]; other site 1127744001066 active-site loop [active] 1127744001067 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1127744001068 AAA domain; Region: AAA_18; pfam13238 1127744001069 shikimate kinase; Reviewed; Region: aroK; PRK00131 1127744001070 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1127744001071 ADP binding site [chemical binding]; other site 1127744001072 magnesium binding site [ion binding]; other site 1127744001073 putative shikimate binding site; other site 1127744001074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744001075 S-adenosylmethionine binding site [chemical binding]; other site 1127744001076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744001077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744001078 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1127744001079 dimerization interface [polypeptide binding]; other site 1127744001080 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1127744001081 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1127744001082 Proline dehydrogenase; Region: Pro_dh; pfam01619 1127744001083 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1127744001084 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1127744001085 Glutamate binding site [chemical binding]; other site 1127744001086 homodimer interface [polypeptide binding]; other site 1127744001087 NAD binding site [chemical binding]; other site 1127744001088 catalytic residues [active] 1127744001089 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1127744001090 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1127744001091 Na binding site [ion binding]; other site 1127744001092 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1127744001093 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1127744001094 Predicted membrane protein [Function unknown]; Region: COG3689 1127744001095 Predicted permeases [General function prediction only]; Region: COG0701 1127744001096 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1127744001097 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1127744001098 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1127744001099 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1127744001100 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 1127744001101 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1127744001102 active site 1127744001103 SAM binding site [chemical binding]; other site 1127744001104 homodimer interface [polypeptide binding]; other site 1127744001105 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1127744001106 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1127744001107 [2Fe-2S] cluster binding site [ion binding]; other site 1127744001108 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1127744001109 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127744001110 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1127744001111 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1127744001112 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1127744001113 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1127744001114 [4Fe-4S] binding site [ion binding]; other site 1127744001115 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1127744001116 molybdopterin cofactor binding site; other site 1127744001117 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1127744001118 molybdopterin cofactor binding site; other site 1127744001119 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1127744001120 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1127744001121 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127744001122 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1127744001123 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1127744001124 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1127744001125 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1127744001126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744001127 putative substrate translocation pore; other site 1127744001128 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 1127744001129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1127744001130 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1127744001131 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1127744001132 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1127744001133 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1127744001134 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1127744001135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744001136 dimer interface [polypeptide binding]; other site 1127744001137 conserved gate region; other site 1127744001138 putative PBP binding loops; other site 1127744001139 ABC-ATPase subunit interface; other site 1127744001140 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1127744001141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1127744001142 substrate binding pocket [chemical binding]; other site 1127744001143 membrane-bound complex binding site; other site 1127744001144 hinge residues; other site 1127744001145 RDD family; Region: RDD; pfam06271 1127744001146 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1127744001147 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744001148 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127744001149 putative Zn2+ binding site [ion binding]; other site 1127744001150 putative DNA binding site [nucleotide binding]; other site 1127744001151 hypothetical protein; Provisional; Region: PRK09272 1127744001152 Predicted ATPase [General function prediction only]; Region: COG3910 1127744001153 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1127744001154 Walker A/P-loop; other site 1127744001155 ATP binding site [chemical binding]; other site 1127744001156 Q-loop/lid; other site 1127744001157 ABC transporter signature motif; other site 1127744001158 Walker B; other site 1127744001159 D-loop; other site 1127744001160 H-loop/switch region; other site 1127744001161 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1127744001162 beta-galactosidase; Region: BGL; TIGR03356 1127744001163 Competence protein J (ComJ); Region: ComJ; pfam11033 1127744001164 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1127744001165 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744001166 dimerization interface [polypeptide binding]; other site 1127744001167 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1127744001168 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1127744001169 dimer interface [polypeptide binding]; other site 1127744001170 putative CheW interface [polypeptide binding]; other site 1127744001171 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1127744001172 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1127744001173 tetramer interface [polypeptide binding]; other site 1127744001174 active site 1127744001175 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1127744001176 active site 1127744001177 dimer interface [polypeptide binding]; other site 1127744001178 magnesium binding site [ion binding]; other site 1127744001179 Predicted transcriptional regulators [Transcription]; Region: COG1733 1127744001180 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1127744001181 Condensation domain; Region: Condensation; pfam00668 1127744001182 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744001183 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744001184 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744001185 acyl-activating enzyme (AAE) consensus motif; other site 1127744001186 AMP binding site [chemical binding]; other site 1127744001187 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744001188 Condensation domain; Region: Condensation; pfam00668 1127744001189 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744001190 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744001191 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1127744001192 acyl-activating enzyme (AAE) consensus motif; other site 1127744001193 AMP binding site [chemical binding]; other site 1127744001194 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744001195 Condensation domain; Region: Condensation; pfam00668 1127744001196 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744001197 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744001198 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744001199 acyl-activating enzyme (AAE) consensus motif; other site 1127744001200 AMP binding site [chemical binding]; other site 1127744001201 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744001202 Condensation domain; Region: Condensation; pfam00668 1127744001203 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744001204 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1127744001205 Condensation domain; Region: Condensation; pfam00668 1127744001206 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744001207 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1127744001208 acyl-activating enzyme (AAE) consensus motif; other site 1127744001209 AMP binding site [chemical binding]; other site 1127744001210 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744001211 Condensation domain; Region: Condensation; pfam00668 1127744001212 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744001213 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744001214 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744001215 acyl-activating enzyme (AAE) consensus motif; other site 1127744001216 AMP binding site [chemical binding]; other site 1127744001217 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744001218 Condensation domain; Region: Condensation; pfam00668 1127744001219 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744001220 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744001221 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744001222 acyl-activating enzyme (AAE) consensus motif; other site 1127744001223 AMP binding site [chemical binding]; other site 1127744001224 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744001225 Condensation domain; Region: Condensation; pfam00668 1127744001226 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1127744001227 Condensation domain; Region: Condensation; pfam00668 1127744001228 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744001229 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1127744001230 acyl-activating enzyme (AAE) consensus motif; other site 1127744001231 AMP binding site [chemical binding]; other site 1127744001232 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744001233 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1127744001234 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1127744001235 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 1127744001236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744001237 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744001238 putative substrate translocation pore; other site 1127744001239 YcxB-like protein; Region: YcxB; pfam14317 1127744001240 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1127744001241 EamA-like transporter family; Region: EamA; pfam00892 1127744001242 EamA-like transporter family; Region: EamA; pfam00892 1127744001243 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1127744001244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744001245 DNA-binding site [nucleotide binding]; DNA binding site 1127744001246 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127744001247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744001248 homodimer interface [polypeptide binding]; other site 1127744001249 catalytic residue [active] 1127744001250 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1127744001251 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 1127744001252 Predicted membrane protein [Function unknown]; Region: COG2364 1127744001253 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127744001254 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1127744001255 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1127744001256 Walker A/P-loop; other site 1127744001257 ATP binding site [chemical binding]; other site 1127744001258 Q-loop/lid; other site 1127744001259 ABC transporter signature motif; other site 1127744001260 Walker B; other site 1127744001261 D-loop; other site 1127744001262 H-loop/switch region; other site 1127744001263 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1127744001264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744001265 dimer interface [polypeptide binding]; other site 1127744001266 conserved gate region; other site 1127744001267 putative PBP binding loops; other site 1127744001268 ABC-ATPase subunit interface; other site 1127744001269 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1127744001270 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1127744001271 substrate binding pocket [chemical binding]; other site 1127744001272 membrane-bound complex binding site; other site 1127744001273 hinge residues; other site 1127744001274 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744001275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744001276 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1127744001277 dimerization interface [polypeptide binding]; other site 1127744001278 UbiD family decarboxylase; Region: TIGR00148 1127744001279 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1127744001280 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1127744001281 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1127744001282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744001283 putative substrate translocation pore; other site 1127744001284 POT family; Region: PTR2; pfam00854 1127744001285 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1127744001286 Right handed beta helix region; Region: Beta_helix; pfam13229 1127744001287 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1127744001288 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1127744001289 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1127744001290 Spore germination protein; Region: Spore_permease; pfam03845 1127744001291 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1127744001292 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1127744001293 Walker A/P-loop; other site 1127744001294 ATP binding site [chemical binding]; other site 1127744001295 Q-loop/lid; other site 1127744001296 ABC transporter signature motif; other site 1127744001297 Walker B; other site 1127744001298 D-loop; other site 1127744001299 H-loop/switch region; other site 1127744001300 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1127744001301 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1127744001302 FtsX-like permease family; Region: FtsX; pfam02687 1127744001303 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127744001304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744001305 active site 1127744001306 phosphorylation site [posttranslational modification] 1127744001307 intermolecular recognition site; other site 1127744001308 dimerization interface [polypeptide binding]; other site 1127744001309 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127744001310 DNA binding site [nucleotide binding] 1127744001311 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1127744001312 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744001313 dimerization interface [polypeptide binding]; other site 1127744001314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744001315 dimer interface [polypeptide binding]; other site 1127744001316 phosphorylation site [posttranslational modification] 1127744001317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744001318 ATP binding site [chemical binding]; other site 1127744001319 Mg2+ binding site [ion binding]; other site 1127744001320 G-X-G motif; other site 1127744001321 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744001322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744001323 TPR motif; other site 1127744001324 binding surface 1127744001325 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744001326 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1127744001327 aspartate kinase; Reviewed; Region: PRK09034 1127744001328 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1127744001329 putative catalytic residues [active] 1127744001330 putative nucleotide binding site [chemical binding]; other site 1127744001331 putative aspartate binding site [chemical binding]; other site 1127744001332 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1127744001333 allosteric regulatory residue; other site 1127744001334 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1127744001335 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1127744001336 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127744001337 ABC-ATPase subunit interface; other site 1127744001338 dimer interface [polypeptide binding]; other site 1127744001339 putative PBP binding regions; other site 1127744001340 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127744001341 ABC-ATPase subunit interface; other site 1127744001342 dimer interface [polypeptide binding]; other site 1127744001343 putative PBP binding regions; other site 1127744001344 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1127744001345 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1127744001346 Walker A/P-loop; other site 1127744001347 ATP binding site [chemical binding]; other site 1127744001348 Q-loop/lid; other site 1127744001349 ABC transporter signature motif; other site 1127744001350 Walker B; other site 1127744001351 D-loop; other site 1127744001352 H-loop/switch region; other site 1127744001353 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1127744001354 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1127744001355 putative ligand binding residues [chemical binding]; other site 1127744001356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744001357 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744001358 putative substrate translocation pore; other site 1127744001359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744001360 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744001361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744001362 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1127744001363 dimer interface [polypeptide binding]; other site 1127744001364 FMN binding site [chemical binding]; other site 1127744001365 NADPH bind site [chemical binding]; other site 1127744001366 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1127744001367 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127744001368 dimerization interface [polypeptide binding]; other site 1127744001369 putative DNA binding site [nucleotide binding]; other site 1127744001370 putative Zn2+ binding site [ion binding]; other site 1127744001371 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1127744001372 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744001373 DNA-binding site [nucleotide binding]; DNA binding site 1127744001374 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127744001375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744001376 homodimer interface [polypeptide binding]; other site 1127744001377 catalytic residue [active] 1127744001378 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1127744001379 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127744001380 inhibitor-cofactor binding pocket; inhibition site 1127744001381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744001382 catalytic residue [active] 1127744001383 succinic semialdehyde dehydrogenase; Region: PLN02278 1127744001384 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1127744001385 tetramerization interface [polypeptide binding]; other site 1127744001386 NAD(P) binding site [chemical binding]; other site 1127744001387 catalytic residues [active] 1127744001388 Sugar transport protein; Region: Sugar_transport; pfam06800 1127744001389 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1127744001390 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1127744001391 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1127744001392 NAD binding site [chemical binding]; other site 1127744001393 homodimer interface [polypeptide binding]; other site 1127744001394 active site 1127744001395 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1127744001396 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1127744001397 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1127744001398 YtkA-like; Region: YtkA; pfam13115 1127744001399 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1127744001400 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1127744001401 NosL; Region: NosL; cl01769 1127744001402 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1127744001403 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1127744001404 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1127744001405 active site 1127744001406 P-loop; other site 1127744001407 phosphorylation site [posttranslational modification] 1127744001408 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1127744001409 active site 1127744001410 phosphorylation site [posttranslational modification] 1127744001411 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1127744001412 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1127744001413 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1127744001414 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1127744001415 tartrate dehydrogenase; Provisional; Region: PRK08194 1127744001416 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1127744001417 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1127744001418 Catalytic site [active] 1127744001419 Dienelactone hydrolase family; Region: DLH; pfam01738 1127744001420 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1127744001421 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1127744001422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744001423 active site 1127744001424 motif I; other site 1127744001425 motif II; other site 1127744001426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744001427 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1127744001428 putative active site [active] 1127744001429 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1127744001430 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1127744001431 hypothetical protein; Provisional; Region: PRK05463 1127744001432 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1127744001433 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1127744001434 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1127744001435 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1127744001436 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1127744001437 Bacterial transcriptional regulator; Region: IclR; pfam01614 1127744001438 Lysophospholipase L1 and related esterases [Amino acid transport and metabolism]; Region: TesA; COG2755 1127744001439 active site 1127744001440 catalytic triad [active] 1127744001441 oxyanion hole [active] 1127744001442 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1127744001443 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1127744001444 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1127744001445 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1127744001446 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1127744001447 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1127744001448 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1127744001449 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1127744001450 active site 1127744001451 catalytic tetrad [active] 1127744001452 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1127744001453 HTH domain; Region: HTH_11; pfam08279 1127744001454 PRD domain; Region: PRD; pfam00874 1127744001455 PRD domain; Region: PRD; pfam00874 1127744001456 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1127744001457 active site 1127744001458 P-loop; other site 1127744001459 phosphorylation site [posttranslational modification] 1127744001460 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1127744001461 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1127744001462 acyl-activating enzyme (AAE) consensus motif; other site 1127744001463 putative AMP binding site [chemical binding]; other site 1127744001464 putative active site [active] 1127744001465 putative CoA binding site [chemical binding]; other site 1127744001466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744001467 S-adenosylmethionine binding site [chemical binding]; other site 1127744001468 short chain dehydrogenase; Provisional; Region: PRK06701 1127744001469 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1127744001470 NAD binding site [chemical binding]; other site 1127744001471 metal binding site [ion binding]; metal-binding site 1127744001472 active site 1127744001473 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1127744001474 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1127744001475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1127744001476 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1127744001477 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1127744001478 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1127744001479 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1127744001480 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1127744001481 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1127744001482 putative DNA binding site [nucleotide binding]; other site 1127744001483 putative Zn2+ binding site [ion binding]; other site 1127744001484 AsnC family; Region: AsnC_trans_reg; pfam01037 1127744001485 DNA topoisomerase III; Provisional; Region: PRK07726 1127744001486 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1127744001487 active site 1127744001488 putative interdomain interaction site [polypeptide binding]; other site 1127744001489 putative metal-binding site [ion binding]; other site 1127744001490 putative nucleotide binding site [chemical binding]; other site 1127744001491 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1127744001492 domain I; other site 1127744001493 DNA binding groove [nucleotide binding] 1127744001494 phosphate binding site [ion binding]; other site 1127744001495 domain II; other site 1127744001496 domain III; other site 1127744001497 nucleotide binding site [chemical binding]; other site 1127744001498 catalytic site [active] 1127744001499 domain IV; other site 1127744001500 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1127744001501 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1127744001502 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1127744001503 VIT family; Region: VIT1; pfam01988 1127744001504 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1127744001505 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1127744001506 metal binding site [ion binding]; metal-binding site 1127744001507 active site 1127744001508 I-site; other site 1127744001509 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1127744001510 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1127744001511 NodB motif; other site 1127744001512 putative active site [active] 1127744001513 putative catalytic site [active] 1127744001514 putative Zn binding site [ion binding]; other site 1127744001515 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1127744001516 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1127744001517 DXD motif; other site 1127744001518 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1127744001519 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1127744001520 Amino acid permease; Region: AA_permease_2; pfam13520 1127744001521 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1127744001522 nudix motif; other site 1127744001523 pyruvate oxidase; Provisional; Region: PRK08611 1127744001524 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1127744001525 PYR/PP interface [polypeptide binding]; other site 1127744001526 tetramer interface [polypeptide binding]; other site 1127744001527 dimer interface [polypeptide binding]; other site 1127744001528 TPP binding site [chemical binding]; other site 1127744001529 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1127744001530 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1127744001531 TPP-binding site [chemical binding]; other site 1127744001532 manganese transport protein MntH; Reviewed; Region: PRK00701 1127744001533 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1127744001534 Predicted membrane protein [Function unknown]; Region: COG2261 1127744001535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1127744001536 EcsC protein family; Region: EcsC; pfam12787 1127744001537 General stress protein [General function prediction only]; Region: GsiB; COG3729 1127744001538 General stress protein [General function prediction only]; Region: GsiB; COG3729 1127744001539 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1127744001540 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1127744001541 dimanganese center [ion binding]; other site 1127744001542 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1127744001543 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1127744001544 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1127744001545 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1127744001546 putative active site [active] 1127744001547 heme pocket [chemical binding]; other site 1127744001548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744001549 ATP binding site [chemical binding]; other site 1127744001550 Mg2+ binding site [ion binding]; other site 1127744001551 G-X-G motif; other site 1127744001552 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1127744001553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744001554 active site 1127744001555 phosphorylation site [posttranslational modification] 1127744001556 intermolecular recognition site; other site 1127744001557 dimerization interface [polypeptide binding]; other site 1127744001558 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1127744001559 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1127744001560 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1127744001561 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1127744001562 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1127744001563 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1127744001564 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1127744001565 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1127744001566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1127744001567 Walker A/P-loop; other site 1127744001568 ATP binding site [chemical binding]; other site 1127744001569 Q-loop/lid; other site 1127744001570 ABC transporter signature motif; other site 1127744001571 Walker B; other site 1127744001572 D-loop; other site 1127744001573 H-loop/switch region; other site 1127744001574 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1127744001575 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1127744001576 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127744001577 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1127744001578 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1127744001579 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1127744001580 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1127744001581 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1127744001582 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1127744001583 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1127744001584 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1127744001585 catalytic residues [active] 1127744001586 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1127744001587 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1127744001588 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1127744001589 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1127744001590 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1127744001591 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1127744001592 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1127744001593 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1127744001594 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1127744001595 ATP binding site [chemical binding]; other site 1127744001596 Mg++ binding site [ion binding]; other site 1127744001597 motif III; other site 1127744001598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127744001599 nucleotide binding region [chemical binding]; other site 1127744001600 ATP-binding site [chemical binding]; other site 1127744001601 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1127744001602 Predicted membrane protein [Function unknown]; Region: COG3428 1127744001603 Bacterial PH domain; Region: DUF304; pfam03703 1127744001604 Bacterial PH domain; Region: DUF304; pfam03703 1127744001605 Bacterial PH domain; Region: DUF304; pfam03703 1127744001606 Rhomboid family; Region: Rhomboid; pfam01694 1127744001607 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1127744001608 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1127744001609 alanine racemase; Region: alr; TIGR00492 1127744001610 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1127744001611 active site 1127744001612 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1127744001613 dimer interface [polypeptide binding]; other site 1127744001614 substrate binding site [chemical binding]; other site 1127744001615 catalytic residues [active] 1127744001616 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1127744001617 ribbon-helix-helix domain containing protein; Region: PHA00617 1127744001618 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1127744001619 Rsbr N terminal; Region: Rsbr_N; pfam08678 1127744001620 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1127744001621 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1127744001622 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1127744001623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744001624 ATP binding site [chemical binding]; other site 1127744001625 Mg2+ binding site [ion binding]; other site 1127744001626 G-X-G motif; other site 1127744001627 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1127744001628 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1127744001629 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1127744001630 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1127744001631 anti sigma factor interaction site; other site 1127744001632 regulatory phosphorylation site [posttranslational modification]; other site 1127744001633 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1127744001634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744001635 ATP binding site [chemical binding]; other site 1127744001636 Mg2+ binding site [ion binding]; other site 1127744001637 G-X-G motif; other site 1127744001638 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1127744001639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744001640 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1127744001641 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744001642 DNA binding residues [nucleotide binding] 1127744001643 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1127744001644 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1127744001645 hydrophobic ligand binding site; other site 1127744001646 hypothetical protein; Provisional; Region: PRK02268 1127744001647 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744001648 MarR family; Region: MarR; pfam01047 1127744001649 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1127744001650 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1127744001651 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1127744001652 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1127744001653 RNA binding site [nucleotide binding]; other site 1127744001654 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1127744001655 hypothetical protein; Provisional; Region: PRK04351 1127744001656 integrase; Provisional; Region: int; PHA02601 1127744001657 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1127744001658 Int/Topo IB signature motif; other site 1127744001659 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 1127744001660 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127744001661 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127744001662 non-specific DNA binding site [nucleotide binding]; other site 1127744001663 salt bridge; other site 1127744001664 sequence-specific DNA binding site [nucleotide binding]; other site 1127744001665 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1127744001666 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1127744001667 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1127744001668 Replication initiation factor; Region: Rep_trans; pfam02486 1127744001669 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1127744001670 nudix motif; other site 1127744001671 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1127744001672 TcpE family; Region: TcpE; pfam12648 1127744001673 AAA-like domain; Region: AAA_10; pfam12846 1127744001674 Domain of unknown function (DUF1874); Region: DUF1874; pfam08960 1127744001675 MAEBL; Provisional; Region: PTZ00121 1127744001676 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1127744001677 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1127744001678 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1127744001679 catalytic residue [active] 1127744001680 NlpC/P60 family; Region: NLPC_P60; pfam00877 1127744001681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744001682 binding surface 1127744001683 TPR motif; other site 1127744001684 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744001685 FRG domain; Region: FRG; pfam08867 1127744001686 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1127744001687 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1127744001688 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1127744001689 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 1127744001690 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1127744001691 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1127744001692 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1127744001693 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1127744001694 conserved cys residue [active] 1127744001695 N-acetylneuraminate lyase; Region: nanA; TIGR00683 1127744001696 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1127744001697 inhibitor site; inhibition site 1127744001698 active site 1127744001699 dimer interface [polypeptide binding]; other site 1127744001700 catalytic residue [active] 1127744001701 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1127744001702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744001703 putative substrate translocation pore; other site 1127744001704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744001705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744001706 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1127744001707 dimerization interface [polypeptide binding]; other site 1127744001708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1127744001709 MOSC domain; Region: MOSC; pfam03473 1127744001710 3-alpha domain; Region: 3-alpha; pfam03475 1127744001711 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1127744001712 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 1127744001713 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1127744001714 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1127744001715 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1127744001716 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1127744001717 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1127744001718 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1127744001719 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1127744001720 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1127744001721 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1127744001722 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1127744001723 active site 1127744001724 catalytic site [active] 1127744001725 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1127744001726 DNA-binding site [nucleotide binding]; DNA binding site 1127744001727 RNA-binding motif; other site 1127744001728 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1127744001729 EamA-like transporter family; Region: EamA; pfam00892 1127744001730 EamA-like transporter family; Region: EamA; pfam00892 1127744001731 Cupin domain; Region: Cupin_2; pfam07883 1127744001732 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127744001733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127744001734 EamA-like transporter family; Region: EamA; pfam00892 1127744001735 EamA-like transporter family; Region: EamA; pfam00892 1127744001736 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127744001737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127744001738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1127744001739 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1127744001740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744001741 DNA-binding site [nucleotide binding]; DNA binding site 1127744001742 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127744001743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744001744 homodimer interface [polypeptide binding]; other site 1127744001745 catalytic residue [active] 1127744001746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744001747 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744001748 putative substrate translocation pore; other site 1127744001749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1127744001750 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1127744001751 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1127744001752 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1127744001753 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1127744001754 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744001755 DNA-binding site [nucleotide binding]; DNA binding site 1127744001756 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127744001757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744001758 homodimer interface [polypeptide binding]; other site 1127744001759 catalytic residue [active] 1127744001760 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1127744001761 putative active site [active] 1127744001762 putative catalytic site [active] 1127744001763 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1127744001764 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127744001765 Predicted transcriptional regulators [Transcription]; Region: COG1733 1127744001766 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1127744001767 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1127744001768 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127744001769 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127744001770 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1127744001771 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1127744001772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744001773 putative substrate translocation pore; other site 1127744001774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744001775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744001776 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1127744001777 putative DNA binding site [nucleotide binding]; other site 1127744001778 arsenical pump membrane protein; Provisional; Region: PRK15445 1127744001779 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1127744001780 transmembrane helices; other site 1127744001781 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1127744001782 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 1127744001783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1127744001784 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1127744001785 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1127744001786 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1127744001787 NodB motif; other site 1127744001788 active site 1127744001789 catalytic site [active] 1127744001790 Zn binding site [ion binding]; other site 1127744001791 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 1127744001792 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1127744001793 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744001794 dimerization interface [polypeptide binding]; other site 1127744001795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744001796 dimer interface [polypeptide binding]; other site 1127744001797 phosphorylation site [posttranslational modification] 1127744001798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744001799 ATP binding site [chemical binding]; other site 1127744001800 Mg2+ binding site [ion binding]; other site 1127744001801 G-X-G motif; other site 1127744001802 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127744001803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744001804 active site 1127744001805 phosphorylation site [posttranslational modification] 1127744001806 intermolecular recognition site; other site 1127744001807 dimerization interface [polypeptide binding]; other site 1127744001808 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127744001809 DNA binding site [nucleotide binding] 1127744001810 EamA-like transporter family; Region: EamA; pfam00892 1127744001811 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1127744001812 EamA-like transporter family; Region: EamA; pfam00892 1127744001813 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1127744001814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744001815 DNA-binding site [nucleotide binding]; DNA binding site 1127744001816 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127744001817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744001818 homodimer interface [polypeptide binding]; other site 1127744001819 catalytic residue [active] 1127744001820 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1127744001821 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127744001822 putative Zn2+ binding site [ion binding]; other site 1127744001823 putative DNA binding site [nucleotide binding]; other site 1127744001824 dimerization interface [polypeptide binding]; other site 1127744001825 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1127744001826 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1127744001827 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127744001828 Histidine kinase; Region: HisKA_3; pfam07730 1127744001829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744001830 ATP binding site [chemical binding]; other site 1127744001831 Mg2+ binding site [ion binding]; other site 1127744001832 G-X-G motif; other site 1127744001833 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127744001834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744001835 active site 1127744001836 phosphorylation site [posttranslational modification] 1127744001837 intermolecular recognition site; other site 1127744001838 dimerization interface [polypeptide binding]; other site 1127744001839 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127744001840 DNA binding residues [nucleotide binding] 1127744001841 dimerization interface [polypeptide binding]; other site 1127744001842 MMPL family; Region: MMPL; pfam03176 1127744001843 MMPL family; Region: MMPL; pfam03176 1127744001844 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1127744001845 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1127744001846 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744001847 DNA-binding site [nucleotide binding]; DNA binding site 1127744001848 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127744001849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744001850 homodimer interface [polypeptide binding]; other site 1127744001851 catalytic residue [active] 1127744001852 4-azaleucine resistance probable transporter AzlC; Region: azlC; TIGR00346 1127744001853 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 1127744001854 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1127744001855 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1127744001856 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1127744001857 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127744001858 DNA binding residues [nucleotide binding] 1127744001859 drug binding residues [chemical binding]; other site 1127744001860 dimer interface [polypeptide binding]; other site 1127744001861 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1127744001862 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1127744001863 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1127744001864 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1127744001865 dimer interface [polypeptide binding]; other site 1127744001866 FMN binding site [chemical binding]; other site 1127744001867 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1127744001868 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127744001869 Zn binding site [ion binding]; other site 1127744001870 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1127744001871 Zn binding site [ion binding]; other site 1127744001872 Predicted membrane protein [Function unknown]; Region: COG2259 1127744001873 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1127744001874 catalytic residues [active] 1127744001875 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1127744001876 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1127744001877 Predicted membrane protein [Function unknown]; Region: COG2323 1127744001878 Predicted membrane protein [Function unknown]; Region: COG2323 1127744001879 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1127744001880 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1127744001881 putative dimer interface [polypeptide binding]; other site 1127744001882 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1127744001883 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1127744001884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744001885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744001886 DoxX-like family; Region: DoxX_2; pfam13564 1127744001887 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1127744001888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744001889 Coenzyme A binding pocket [chemical binding]; other site 1127744001890 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1127744001891 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1127744001892 ABC transporter; Region: ABC_tran_2; pfam12848 1127744001893 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1127744001894 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1127744001895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1127744001896 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744001897 MarR family; Region: MarR; pfam01047 1127744001898 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1127744001899 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1127744001900 dimer interface [polypeptide binding]; other site 1127744001901 FMN binding site [chemical binding]; other site 1127744001902 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744001903 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127744001904 putative DNA binding site [nucleotide binding]; other site 1127744001905 putative Zn2+ binding site [ion binding]; other site 1127744001906 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1127744001907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744001908 putative substrate translocation pore; other site 1127744001909 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1127744001910 hypothetical protein; Provisional; Region: PRK10621 1127744001911 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1127744001912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744001913 DNA-binding site [nucleotide binding]; DNA binding site 1127744001914 FCD domain; Region: FCD; pfam07729 1127744001915 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1127744001916 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744001917 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744001918 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1127744001919 active site 1127744001920 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1127744001921 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1127744001922 homodimer interface [polypeptide binding]; other site 1127744001923 active site 1127744001924 TDP-binding site; other site 1127744001925 acceptor substrate-binding pocket; other site 1127744001926 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1127744001927 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1127744001928 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1127744001929 dimer interface [polypeptide binding]; other site 1127744001930 active site 1127744001931 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1127744001932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744001933 Coenzyme A binding pocket [chemical binding]; other site 1127744001934 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1127744001935 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1127744001936 Zn2+ binding site [ion binding]; other site 1127744001937 Mg2+ binding site [ion binding]; other site 1127744001938 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1127744001939 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1127744001940 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1127744001941 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1127744001942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744001943 putative substrate translocation pore; other site 1127744001944 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1127744001945 active site 1127744001946 P-loop; other site 1127744001947 phosphorylation site [posttranslational modification] 1127744001948 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1127744001949 active site 1127744001950 methionine cluster; other site 1127744001951 phosphorylation site [posttranslational modification] 1127744001952 metal binding site [ion binding]; metal-binding site 1127744001953 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1127744001954 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1127744001955 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1127744001956 beta-galactosidase; Region: BGL; TIGR03356 1127744001957 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1127744001958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744001959 DNA-binding site [nucleotide binding]; DNA binding site 1127744001960 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1127744001961 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1127744001962 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1127744001963 nucleotide binding site [chemical binding]; other site 1127744001964 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1127744001965 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1127744001966 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1127744001967 thiamine-monophosphate kinase; Region: thiL; TIGR01379 1127744001968 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1127744001969 ATP binding site [chemical binding]; other site 1127744001970 dimerization interface [polypeptide binding]; other site 1127744001971 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1127744001972 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1127744001973 Glycoprotease family; Region: Peptidase_M22; pfam00814 1127744001974 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1127744001975 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744001976 Coenzyme A binding pocket [chemical binding]; other site 1127744001977 UGMP family protein; Validated; Region: PRK09604 1127744001978 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1127744001979 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1127744001980 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1127744001981 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1127744001982 ABC transporter; Region: ABC_tran_2; pfam12848 1127744001983 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1127744001984 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1127744001985 trimer interface [polypeptide binding]; other site 1127744001986 dimer interface [polypeptide binding]; other site 1127744001987 putative active site [active] 1127744001988 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1127744001989 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1127744001990 CoA binding domain; Region: CoA_binding; pfam02629 1127744001991 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1127744001992 Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945 1127744001993 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1127744001994 CAAX protease self-immunity; Region: Abi; pfam02517 1127744001995 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1127744001996 oligomerisation interface [polypeptide binding]; other site 1127744001997 mobile loop; other site 1127744001998 roof hairpin; other site 1127744001999 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1127744002000 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1127744002001 ring oligomerisation interface [polypeptide binding]; other site 1127744002002 ATP/Mg binding site [chemical binding]; other site 1127744002003 stacking interactions; other site 1127744002004 hinge regions; other site 1127744002005 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1127744002006 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127744002007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127744002008 acyl carrier protein; Provisional; Region: PRK07081 1127744002009 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1127744002010 active site 1127744002011 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1127744002012 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1127744002013 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1127744002014 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1127744002015 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1127744002016 GTP cyclohydrolase I; Provisional; Region: PLN03044 1127744002017 homodecamer interface [polypeptide binding]; other site 1127744002018 active site 1127744002019 putative catalytic site residues [active] 1127744002020 zinc binding site [ion binding]; other site 1127744002021 GTP-CH-I/GFRP interaction surface; other site 1127744002022 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744002023 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1127744002024 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1127744002025 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1127744002026 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1127744002027 dimer interface [polypeptide binding]; other site 1127744002028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744002029 catalytic residue [active] 1127744002030 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744002031 AMP-binding enzyme; Region: AMP-binding; pfam00501 1127744002032 acyl-activating enzyme (AAE) consensus motif; other site 1127744002033 AMP binding site [chemical binding]; other site 1127744002034 Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603 1127744002035 Ligand Binding Site [chemical binding]; other site 1127744002036 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1127744002037 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127744002038 catalytic residue [active] 1127744002039 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1127744002040 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1127744002041 active site 1127744002042 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127744002043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1127744002044 Walker A/P-loop; other site 1127744002045 ATP binding site [chemical binding]; other site 1127744002046 Q-loop/lid; other site 1127744002047 ABC transporter signature motif; other site 1127744002048 Walker B; other site 1127744002049 D-loop; other site 1127744002050 H-loop/switch region; other site 1127744002051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1127744002052 Walker A motif; other site 1127744002053 ATP binding site [chemical binding]; other site 1127744002054 Walker B motif; other site 1127744002055 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744002056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744002057 TPR motif; other site 1127744002058 TPR repeat; Region: TPR_11; pfam13414 1127744002059 binding surface 1127744002060 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1127744002061 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1127744002062 inhibitor binding site; inhibition site 1127744002063 catalytic Zn binding site [ion binding]; other site 1127744002064 structural Zn binding site [ion binding]; other site 1127744002065 NADP binding site [chemical binding]; other site 1127744002066 tetramer interface [polypeptide binding]; other site 1127744002067 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1127744002068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744002069 putative substrate translocation pore; other site 1127744002070 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1127744002071 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1127744002072 putative substrate binding site [chemical binding]; other site 1127744002073 putative ATP binding site [chemical binding]; other site 1127744002074 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1127744002075 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 1127744002076 DNA-directed RNA polymerase subunit F; Provisional; Region: PRK14981 1127744002077 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1127744002078 Repair protein; Region: Repair_PSII; pfam04536 1127744002079 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1127744002080 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1127744002081 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1127744002082 Ion channel; Region: Ion_trans_2; pfam07885 1127744002083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744002084 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1127744002085 putative substrate translocation pore; other site 1127744002086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744002087 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1127744002088 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1127744002089 putative NAD(P) binding site [chemical binding]; other site 1127744002090 catalytic Zn binding site [ion binding]; other site 1127744002091 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1127744002092 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1127744002093 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1127744002094 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1127744002095 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1127744002096 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1127744002097 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1127744002098 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1127744002099 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1127744002100 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1127744002101 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1127744002102 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1127744002103 MoxR-like ATPases [General function prediction only]; Region: COG0714 1127744002104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744002105 Walker A motif; other site 1127744002106 ATP binding site [chemical binding]; other site 1127744002107 Walker B motif; other site 1127744002108 arginine finger; other site 1127744002109 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1127744002110 Protein of unknown function DUF58; Region: DUF58; pfam01882 1127744002111 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1127744002112 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1127744002113 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1127744002114 GMP synthase; Reviewed; Region: guaA; PRK00074 1127744002115 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1127744002116 AMP/PPi binding site [chemical binding]; other site 1127744002117 candidate oxyanion hole; other site 1127744002118 catalytic triad [active] 1127744002119 potential glutamine specificity residues [chemical binding]; other site 1127744002120 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1127744002121 ATP Binding subdomain [chemical binding]; other site 1127744002122 Ligand Binding sites [chemical binding]; other site 1127744002123 Dimerization subdomain; other site 1127744002124 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1127744002125 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744002126 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744002127 DNA binding residues [nucleotide binding] 1127744002128 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1127744002129 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1127744002130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1127744002131 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1127744002132 NETI protein; Region: NETI; pfam14044 1127744002133 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1127744002134 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1127744002135 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1127744002136 NAD binding site [chemical binding]; other site 1127744002137 ATP-grasp domain; Region: ATP-grasp; pfam02222 1127744002138 adenylosuccinate lyase; Provisional; Region: PRK07492 1127744002139 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1127744002140 tetramer interface [polypeptide binding]; other site 1127744002141 active site 1127744002142 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1127744002143 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1127744002144 ATP binding site [chemical binding]; other site 1127744002145 active site 1127744002146 substrate binding site [chemical binding]; other site 1127744002147 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1127744002148 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1127744002149 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1127744002150 putative active site [active] 1127744002151 catalytic triad [active] 1127744002152 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1127744002153 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1127744002154 dimerization interface [polypeptide binding]; other site 1127744002155 ATP binding site [chemical binding]; other site 1127744002156 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1127744002157 dimerization interface [polypeptide binding]; other site 1127744002158 ATP binding site [chemical binding]; other site 1127744002159 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1127744002160 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1127744002161 active site 1127744002162 tetramer interface [polypeptide binding]; other site 1127744002163 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127744002164 active site 1127744002165 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1127744002166 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1127744002167 dimerization interface [polypeptide binding]; other site 1127744002168 putative ATP binding site [chemical binding]; other site 1127744002169 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1127744002170 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1127744002171 active site 1127744002172 substrate binding site [chemical binding]; other site 1127744002173 cosubstrate binding site; other site 1127744002174 catalytic site [active] 1127744002175 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1127744002176 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1127744002177 purine monophosphate binding site [chemical binding]; other site 1127744002178 dimer interface [polypeptide binding]; other site 1127744002179 putative catalytic residues [active] 1127744002180 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1127744002181 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1127744002182 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1127744002183 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1127744002184 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1127744002185 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1127744002186 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1127744002187 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127744002188 putative DNA binding site [nucleotide binding]; other site 1127744002189 putative Zn2+ binding site [ion binding]; other site 1127744002190 AsnC family; Region: AsnC_trans_reg; pfam01037 1127744002191 putative transporter; Provisional; Region: PRK11021 1127744002192 Spore germination protein; Region: Spore_permease; cl17796 1127744002193 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1127744002194 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127744002195 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1127744002196 active site 1127744002197 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127744002198 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1127744002199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1127744002200 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1127744002201 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1127744002202 active site 1127744002203 FMN binding site [chemical binding]; other site 1127744002204 substrate binding site [chemical binding]; other site 1127744002205 3Fe-4S cluster binding site [ion binding]; other site 1127744002206 PcrB family; Region: PcrB; pfam01884 1127744002207 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1127744002208 substrate binding site [chemical binding]; other site 1127744002209 putative active site [active] 1127744002210 dimer interface [polypeptide binding]; other site 1127744002211 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1127744002212 Part of AAA domain; Region: AAA_19; pfam13245 1127744002213 Family description; Region: UvrD_C_2; pfam13538 1127744002214 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1127744002215 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1127744002216 nucleotide binding pocket [chemical binding]; other site 1127744002217 K-X-D-G motif; other site 1127744002218 catalytic site [active] 1127744002219 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1127744002220 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1127744002221 Helix-hairpin-helix motif; Region: HHH; pfam00633 1127744002222 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1127744002223 Dimer interface [polypeptide binding]; other site 1127744002224 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1127744002225 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1127744002226 putative dimer interface [polypeptide binding]; other site 1127744002227 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1127744002228 putative dimer interface [polypeptide binding]; other site 1127744002229 H+ Antiporter protein; Region: 2A0121; TIGR00900 1127744002230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744002231 putative substrate translocation pore; other site 1127744002232 Condensation domain; Region: Condensation; pfam00668 1127744002233 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744002234 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744002235 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1127744002236 acyl-activating enzyme (AAE) consensus motif; other site 1127744002237 AMP binding site [chemical binding]; other site 1127744002238 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744002239 Condensation domain; Region: Condensation; pfam00668 1127744002240 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1127744002241 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1127744002242 Beta-lactamase; Region: Beta-lactamase; pfam00144 1127744002243 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1127744002244 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1127744002245 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1127744002246 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1127744002247 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1127744002248 FkbH-like domain; Region: FkbH; TIGR01686 1127744002249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744002250 active site 1127744002251 motif I; other site 1127744002252 motif II; other site 1127744002253 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1127744002254 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127744002255 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127744002256 active site 1127744002257 Condensation domain; Region: Condensation; pfam00668 1127744002258 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744002259 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744002260 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744002261 acyl-activating enzyme (AAE) consensus motif; other site 1127744002262 AMP binding site [chemical binding]; other site 1127744002263 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744002264 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744002265 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1127744002266 active site 1127744002267 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1127744002268 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1127744002269 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1127744002270 putative NADP binding site [chemical binding]; other site 1127744002271 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1127744002272 active site 1127744002273 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744002274 Condensation domain; Region: Condensation; pfam00668 1127744002275 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744002276 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744002277 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744002278 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744002279 acyl-activating enzyme (AAE) consensus motif; other site 1127744002280 AMP binding site [chemical binding]; other site 1127744002281 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744002282 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744002283 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1127744002284 active site 1127744002285 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1127744002286 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1127744002287 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1127744002288 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1127744002289 putative NADP binding site [chemical binding]; other site 1127744002290 active site 1127744002291 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744002292 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744002293 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1127744002294 active site 1127744002295 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1127744002296 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744002297 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744002298 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1127744002299 active site 1127744002300 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1127744002301 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1127744002302 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1127744002303 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1127744002304 putative NADP binding site [chemical binding]; other site 1127744002305 active site 1127744002306 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744002307 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744002308 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1127744002309 active site 1127744002310 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1127744002311 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744002312 Condensation domain; Region: Condensation; pfam00668 1127744002313 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744002314 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744002315 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 1127744002316 Acid Phosphatase; Region: Acid_PPase; cl17256 1127744002317 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744002318 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1127744002319 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1127744002320 active site 1127744002321 ATP binding site [chemical binding]; other site 1127744002322 substrate binding site [chemical binding]; other site 1127744002323 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1127744002324 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1127744002325 active site 1127744002326 dimer interface [polypeptide binding]; other site 1127744002327 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1127744002328 MgtC family; Region: MgtC; pfam02308 1127744002329 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1127744002330 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1127744002331 Na binding site [ion binding]; other site 1127744002332 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1127744002333 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1127744002334 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1127744002335 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1127744002336 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1127744002337 GatB domain; Region: GatB_Yqey; pfam02637 1127744002338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744002339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744002340 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1127744002341 Protein export membrane protein; Region: SecD_SecF; cl14618 1127744002342 putative lipid kinase; Reviewed; Region: PRK13337 1127744002343 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1127744002344 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1127744002345 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1127744002346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744002347 S-adenosylmethionine binding site [chemical binding]; other site 1127744002348 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 1127744002349 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1127744002350 active site 1127744002351 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1127744002352 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1127744002353 Predicted membrane protein [Function unknown]; Region: COG2323 1127744002354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744002355 binding surface 1127744002356 TPR motif; other site 1127744002357 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744002358 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744002359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1127744002360 TPR motif; other site 1127744002361 binding surface 1127744002362 hypothetical protein; Provisional; Region: PRK12378 1127744002363 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744002364 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744002365 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1127744002366 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1127744002367 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1127744002368 NADP binding site [chemical binding]; other site 1127744002369 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1127744002370 CotJB protein; Region: CotJB; pfam12652 1127744002371 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1127744002372 dimanganese center [ion binding]; other site 1127744002373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744002374 Coenzyme A binding pocket [chemical binding]; other site 1127744002375 YesK-like protein; Region: YesK; pfam14150 1127744002376 Predicted integral membrane protein [Function unknown]; Region: COG5578 1127744002377 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1127744002378 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744002379 dimerization interface [polypeptide binding]; other site 1127744002380 Histidine kinase; Region: His_kinase; pfam06580 1127744002381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744002382 ATP binding site [chemical binding]; other site 1127744002383 Mg2+ binding site [ion binding]; other site 1127744002384 G-X-G motif; other site 1127744002385 Response regulator receiver domain; Region: Response_reg; pfam00072 1127744002386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744002387 active site 1127744002388 phosphorylation site [posttranslational modification] 1127744002389 intermolecular recognition site; other site 1127744002390 dimerization interface [polypeptide binding]; other site 1127744002391 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127744002392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127744002393 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1127744002394 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1127744002395 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1127744002396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744002397 dimer interface [polypeptide binding]; other site 1127744002398 conserved gate region; other site 1127744002399 putative PBP binding loops; other site 1127744002400 ABC-ATPase subunit interface; other site 1127744002401 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1127744002402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744002403 dimer interface [polypeptide binding]; other site 1127744002404 conserved gate region; other site 1127744002405 putative PBP binding loops; other site 1127744002406 ABC-ATPase subunit interface; other site 1127744002407 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1127744002408 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127744002409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127744002410 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1127744002411 active site 1127744002412 catalytic triad [active] 1127744002413 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 1127744002414 Predicted integral membrane protein [Function unknown]; Region: COG5578 1127744002415 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1127744002416 metal binding site [ion binding]; metal-binding site 1127744002417 active site 1127744002418 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1127744002419 metal binding site [ion binding]; metal-binding site 1127744002420 active site 1127744002421 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1127744002422 active site 1127744002423 catalytic triad [active] 1127744002424 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1127744002425 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1127744002426 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1127744002427 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1127744002428 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1127744002429 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1127744002430 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1127744002431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744002432 dimer interface [polypeptide binding]; other site 1127744002433 putative PBP binding loops; other site 1127744002434 ABC-ATPase subunit interface; other site 1127744002435 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1127744002436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744002437 dimer interface [polypeptide binding]; other site 1127744002438 conserved gate region; other site 1127744002439 putative PBP binding loops; other site 1127744002440 ABC-ATPase subunit interface; other site 1127744002441 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1127744002442 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1127744002443 NAD(P) binding site [chemical binding]; other site 1127744002444 LDH/MDH dimer interface [polypeptide binding]; other site 1127744002445 substrate binding site [chemical binding]; other site 1127744002446 Predicted membrane protein [Function unknown]; Region: COG2323 1127744002447 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1127744002448 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127744002449 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1127744002450 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1127744002451 Uncharacterized small protein [Function unknown]; Region: COG5583 1127744002452 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1127744002453 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1127744002454 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1127744002455 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1127744002456 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1127744002457 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1127744002458 Cytochrome P450; Region: p450; pfam00067 1127744002459 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1127744002460 Flavodoxin; Region: Flavodoxin_1; pfam00258 1127744002461 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1127744002462 FAD binding pocket [chemical binding]; other site 1127744002463 FAD binding motif [chemical binding]; other site 1127744002464 catalytic residues [active] 1127744002465 NAD binding pocket [chemical binding]; other site 1127744002466 phosphate binding motif [ion binding]; other site 1127744002467 beta-alpha-beta structure motif; other site 1127744002468 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1127744002469 Sulfatase; Region: Sulfatase; pfam00884 1127744002470 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1127744002471 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1127744002472 substrate binding site; other site 1127744002473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127744002474 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1127744002475 NAD(P) binding site [chemical binding]; other site 1127744002476 active site 1127744002477 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1127744002478 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1127744002479 active site 1127744002480 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1127744002481 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 1127744002482 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744002483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744002484 putative substrate translocation pore; other site 1127744002485 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1127744002486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744002487 active site 1127744002488 motif I; other site 1127744002489 motif II; other site 1127744002490 amino acid transporter; Region: 2A0306; TIGR00909 1127744002491 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1127744002492 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1127744002493 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127744002494 NAD(P) binding site [chemical binding]; other site 1127744002495 catalytic residues [active] 1127744002496 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1127744002497 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1127744002498 dimer interface [polypeptide binding]; other site 1127744002499 putative CheW interface [polypeptide binding]; other site 1127744002500 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1127744002501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1127744002502 Walker A/P-loop; other site 1127744002503 ATP binding site [chemical binding]; other site 1127744002504 Q-loop/lid; other site 1127744002505 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1127744002506 ABC transporter signature motif; other site 1127744002507 Walker B; other site 1127744002508 D-loop; other site 1127744002509 ABC transporter; Region: ABC_tran_2; pfam12848 1127744002510 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1127744002511 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1127744002512 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1127744002513 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1127744002514 DNA binding residues [nucleotide binding] 1127744002515 putative dimer interface [polypeptide binding]; other site 1127744002516 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1127744002517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744002518 putative substrate translocation pore; other site 1127744002519 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1127744002520 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1127744002521 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1127744002522 ABC transporter; Region: ABC_tran_2; pfam12848 1127744002523 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1127744002524 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1127744002525 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1127744002526 ATP binding site [chemical binding]; other site 1127744002527 putative Mg++ binding site [ion binding]; other site 1127744002528 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127744002529 nucleotide binding region [chemical binding]; other site 1127744002530 ATP-binding site [chemical binding]; other site 1127744002531 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1127744002532 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1127744002533 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1127744002534 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1127744002535 NAD(P) binding site [chemical binding]; other site 1127744002536 substrate binding site [chemical binding]; other site 1127744002537 dimer interface [polypeptide binding]; other site 1127744002538 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1127744002539 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1127744002540 Walker A/P-loop; other site 1127744002541 ATP binding site [chemical binding]; other site 1127744002542 Q-loop/lid; other site 1127744002543 ABC transporter signature motif; other site 1127744002544 Walker B; other site 1127744002545 D-loop; other site 1127744002546 H-loop/switch region; other site 1127744002547 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1127744002548 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127744002549 ABC-ATPase subunit interface; other site 1127744002550 dimer interface [polypeptide binding]; other site 1127744002551 putative PBP binding regions; other site 1127744002552 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1127744002553 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127744002554 ABC-ATPase subunit interface; other site 1127744002555 dimer interface [polypeptide binding]; other site 1127744002556 putative PBP binding regions; other site 1127744002557 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1127744002558 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1127744002559 siderophore binding site; other site 1127744002560 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1127744002561 Heat induced stress protein YflT; Region: YflT; pfam11181 1127744002562 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1127744002563 Amb_all domain; Region: Amb_all; smart00656 1127744002564 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1127744002565 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1127744002566 transmembrane helices; other site 1127744002567 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1127744002568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744002569 ATP binding site [chemical binding]; other site 1127744002570 Mg2+ binding site [ion binding]; other site 1127744002571 G-X-G motif; other site 1127744002572 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1127744002573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744002574 active site 1127744002575 phosphorylation site [posttranslational modification] 1127744002576 intermolecular recognition site; other site 1127744002577 dimerization interface [polypeptide binding]; other site 1127744002578 Transcriptional regulator; Region: CitT; pfam12431 1127744002579 HTH domain; Region: HTH_11; cl17392 1127744002580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1127744002581 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1127744002582 Citrate transporter; Region: CitMHS; pfam03600 1127744002583 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1127744002584 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1127744002585 active site 1127744002586 dimer interface [polypeptide binding]; other site 1127744002587 acylphosphatase; Provisional; Region: PRK14420 1127744002588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1127744002589 MOSC domain; Region: MOSC; pfam03473 1127744002590 3-alpha domain; Region: 3-alpha; pfam03475 1127744002591 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1127744002592 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1127744002593 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1127744002594 active site 1127744002595 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1127744002596 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1127744002597 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1127744002598 active site turn [active] 1127744002599 phosphorylation site [posttranslational modification] 1127744002600 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1127744002601 Sulfatase; Region: Sulfatase; pfam00884 1127744002602 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1127744002603 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1127744002604 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1127744002605 Spore germination protein; Region: Spore_permease; cl17796 1127744002606 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1127744002607 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1127744002608 active site turn [active] 1127744002609 phosphorylation site [posttranslational modification] 1127744002610 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1127744002611 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1127744002612 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1127744002613 Ca binding site [ion binding]; other site 1127744002614 active site 1127744002615 catalytic site [active] 1127744002616 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1127744002617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744002618 DNA-binding site [nucleotide binding]; DNA binding site 1127744002619 UTRA domain; Region: UTRA; pfam07702 1127744002620 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1127744002621 dimer interface [polypeptide binding]; other site 1127744002622 FMN binding site [chemical binding]; other site 1127744002623 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1127744002624 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1127744002625 active site 1127744002626 metal binding site [ion binding]; metal-binding site 1127744002627 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1127744002628 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1127744002629 active site 1127744002630 metal binding site [ion binding]; metal-binding site 1127744002631 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1127744002632 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1127744002633 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1127744002634 proposed catalytic triad [active] 1127744002635 conserved cys residue [active] 1127744002636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744002637 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744002638 putative substrate translocation pore; other site 1127744002639 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1127744002640 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1127744002641 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1127744002642 active site 1127744002643 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1127744002644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744002645 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744002646 putative substrate translocation pore; other site 1127744002647 calcium/proton exchanger (cax); Region: cax; TIGR00378 1127744002648 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1127744002649 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1127744002650 YfkD-like protein; Region: YfkD; pfam14167 1127744002651 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1127744002652 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1127744002653 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1127744002654 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127744002655 FeS/SAM binding site; other site 1127744002656 YfkB-like domain; Region: YfkB; pfam08756 1127744002657 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1127744002658 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1127744002659 NodB motif; other site 1127744002660 active site 1127744002661 catalytic site [active] 1127744002662 Cd binding site [ion binding]; other site 1127744002663 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1127744002664 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1127744002665 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1127744002666 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1127744002667 oligomer interface [polypeptide binding]; other site 1127744002668 metal binding site [ion binding]; metal-binding site 1127744002669 metal binding site [ion binding]; metal-binding site 1127744002670 putative Cl binding site [ion binding]; other site 1127744002671 aspartate ring; other site 1127744002672 basic sphincter; other site 1127744002673 hydrophobic gate; other site 1127744002674 periplasmic entrance; other site 1127744002675 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1127744002676 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1127744002677 minor groove reading motif; other site 1127744002678 helix-hairpin-helix signature motif; other site 1127744002679 substrate binding pocket [chemical binding]; other site 1127744002680 active site 1127744002681 YfzA-like protein; Region: YfzA; pfam14118 1127744002682 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1127744002683 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1127744002684 FMN binding site [chemical binding]; other site 1127744002685 active site 1127744002686 catalytic residues [active] 1127744002687 substrate binding site [chemical binding]; other site 1127744002688 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 1127744002689 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1127744002690 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1127744002691 tetramer interface [polypeptide binding]; other site 1127744002692 TPP-binding site [chemical binding]; other site 1127744002693 heterodimer interface [polypeptide binding]; other site 1127744002694 phosphorylation loop region [posttranslational modification] 1127744002695 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1127744002696 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1127744002697 alpha subunit interface [polypeptide binding]; other site 1127744002698 TPP binding site [chemical binding]; other site 1127744002699 heterodimer interface [polypeptide binding]; other site 1127744002700 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1127744002701 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1127744002702 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1127744002703 E3 interaction surface; other site 1127744002704 lipoyl attachment site [posttranslational modification]; other site 1127744002705 e3 binding domain; Region: E3_binding; pfam02817 1127744002706 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1127744002707 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1127744002708 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127744002709 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1127744002710 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1127744002711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744002712 Walker A motif; other site 1127744002713 ATP binding site [chemical binding]; other site 1127744002714 Walker B motif; other site 1127744002715 arginine finger; other site 1127744002716 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1127744002717 acid-soluble spore protein H; Provisional; Region: sspH; PRK03174 1127744002718 hypothetical protein; Provisional; Region: PRK02237 1127744002719 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1127744002720 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1127744002721 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1127744002722 NAD binding site [chemical binding]; other site 1127744002723 sugar binding site [chemical binding]; other site 1127744002724 divalent metal binding site [ion binding]; other site 1127744002725 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1127744002726 dimer interface [polypeptide binding]; other site 1127744002727 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1127744002728 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1127744002729 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1127744002730 putative active site [active] 1127744002731 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1127744002732 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1127744002733 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1127744002734 active site turn [active] 1127744002735 phosphorylation site [posttranslational modification] 1127744002736 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1127744002737 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1127744002738 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127744002739 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1127744002740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1127744002741 Walker A/P-loop; other site 1127744002742 ATP binding site [chemical binding]; other site 1127744002743 Q-loop/lid; other site 1127744002744 ABC transporter signature motif; other site 1127744002745 Walker B; other site 1127744002746 D-loop; other site 1127744002747 H-loop/switch region; other site 1127744002748 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127744002749 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1127744002750 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1127744002751 Walker A/P-loop; other site 1127744002752 ATP binding site [chemical binding]; other site 1127744002753 Q-loop/lid; other site 1127744002754 ABC transporter signature motif; other site 1127744002755 Walker B; other site 1127744002756 D-loop; other site 1127744002757 H-loop/switch region; other site 1127744002758 Predicted membrane protein [Function unknown]; Region: COG2259 1127744002759 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1127744002760 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1127744002761 putative metal binding site [ion binding]; other site 1127744002762 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127744002763 active site 1127744002764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127744002765 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1127744002766 Histidine kinase; Region: HisKA_3; pfam07730 1127744002767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744002768 ATP binding site [chemical binding]; other site 1127744002769 Mg2+ binding site [ion binding]; other site 1127744002770 G-X-G motif; other site 1127744002771 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127744002772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744002773 active site 1127744002774 phosphorylation site [posttranslational modification] 1127744002775 intermolecular recognition site; other site 1127744002776 dimerization interface [polypeptide binding]; other site 1127744002777 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127744002778 DNA binding residues [nucleotide binding] 1127744002779 dimerization interface [polypeptide binding]; other site 1127744002780 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1127744002781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1127744002782 Walker A/P-loop; other site 1127744002783 ATP binding site [chemical binding]; other site 1127744002784 Q-loop/lid; other site 1127744002785 ABC transporter signature motif; other site 1127744002786 Walker B; other site 1127744002787 D-loop; other site 1127744002788 H-loop/switch region; other site 1127744002789 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1127744002790 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1127744002791 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1127744002792 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1127744002793 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1127744002794 Predicted transcriptional regulators [Transcription]; Region: COG1695 1127744002795 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1127744002796 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1127744002797 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1127744002798 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1127744002799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744002800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744002801 H+ Antiporter protein; Region: 2A0121; TIGR00900 1127744002802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744002803 putative substrate translocation pore; other site 1127744002804 metal-dependent hydrolase; Provisional; Region: PRK13291 1127744002805 DinB superfamily; Region: DinB_2; pfam12867 1127744002806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744002807 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744002808 putative substrate translocation pore; other site 1127744002809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744002810 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744002811 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127744002812 putative Zn2+ binding site [ion binding]; other site 1127744002813 putative DNA binding site [nucleotide binding]; other site 1127744002814 Predicted integral membrane protein [Function unknown]; Region: COG0392 1127744002815 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1127744002816 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1127744002817 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1127744002818 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1127744002819 siderophore binding site; other site 1127744002820 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1127744002821 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127744002822 ABC-ATPase subunit interface; other site 1127744002823 dimer interface [polypeptide binding]; other site 1127744002824 putative PBP binding regions; other site 1127744002825 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1127744002826 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127744002827 ABC-ATPase subunit interface; other site 1127744002828 dimer interface [polypeptide binding]; other site 1127744002829 putative PBP binding regions; other site 1127744002830 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1127744002831 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1127744002832 putative FMN binding site [chemical binding]; other site 1127744002833 YfhD-like protein; Region: YfhD; pfam14151 1127744002834 YfhE-like protein; Region: YfhE; pfam14152 1127744002835 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1127744002836 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1127744002837 putative NAD(P) binding site [chemical binding]; other site 1127744002838 putative active site [active] 1127744002839 recombination regulator RecX; Provisional; Region: recX; PRK14135 1127744002840 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1127744002841 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1127744002842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744002843 putative substrate translocation pore; other site 1127744002844 Small acid-soluble spore protein K family; Region: SspK; pfam08176 1127744002845 WVELL protein; Region: WVELL; pfam14043 1127744002846 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1127744002847 Bacterial SH3 domain; Region: SH3_3; pfam08239 1127744002848 SdpI/YhfL protein family; Region: SdpI; pfam13630 1127744002849 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1127744002850 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1127744002851 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1127744002852 catalytic site [active] 1127744002853 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1127744002854 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1127744002855 Ligand binding site; other site 1127744002856 Putative Catalytic site; other site 1127744002857 DXD motif; other site 1127744002858 Predicted membrane protein [Function unknown]; Region: COG4485 1127744002859 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1127744002860 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1127744002861 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1127744002862 minor groove reading motif; other site 1127744002863 helix-hairpin-helix signature motif; other site 1127744002864 substrate binding pocket [chemical binding]; other site 1127744002865 active site 1127744002866 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1127744002867 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1127744002868 DNA binding and oxoG recognition site [nucleotide binding] 1127744002869 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1127744002870 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1127744002871 putative NAD(P) binding site [chemical binding]; other site 1127744002872 active site 1127744002873 YgaB-like protein; Region: YgaB; pfam14182 1127744002874 hypothetical protein; Provisional; Region: PRK13662 1127744002875 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127744002876 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1127744002877 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1127744002878 Walker A/P-loop; other site 1127744002879 ATP binding site [chemical binding]; other site 1127744002880 Q-loop/lid; other site 1127744002881 ABC transporter signature motif; other site 1127744002882 Walker B; other site 1127744002883 D-loop; other site 1127744002884 H-loop/switch region; other site 1127744002885 Predicted membrane protein [Function unknown]; Region: COG4129 1127744002886 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1127744002887 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1127744002888 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127744002889 inhibitor-cofactor binding pocket; inhibition site 1127744002890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744002891 catalytic residue [active] 1127744002892 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1127744002893 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1127744002894 catalytic triad [active] 1127744002895 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1127744002896 metal binding site 2 [ion binding]; metal-binding site 1127744002897 putative DNA binding helix; other site 1127744002898 metal binding site 1 [ion binding]; metal-binding site 1127744002899 dimer interface [polypeptide binding]; other site 1127744002900 structural Zn2+ binding site [ion binding]; other site 1127744002901 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1127744002902 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1127744002903 SpoOM protein; Region: Spo0M; pfam07070 1127744002904 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1127744002905 Coat F domain; Region: Coat_F; pfam07875 1127744002906 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1127744002907 active site pocket [active] 1127744002908 oxyanion hole [active] 1127744002909 catalytic triad [active] 1127744002910 active site nucleophile [active] 1127744002911 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1127744002912 ThiC-associated domain; Region: ThiC-associated; pfam13667 1127744002913 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1127744002914 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1127744002915 FAD binding domain; Region: FAD_binding_4; pfam01565 1127744002916 Berberine and berberine like; Region: BBE; pfam08031 1127744002917 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1127744002918 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1127744002919 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1127744002920 tetramer interface [polypeptide binding]; other site 1127744002921 heme binding pocket [chemical binding]; other site 1127744002922 NADPH binding site [chemical binding]; other site 1127744002923 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1127744002924 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1127744002925 Walker A/P-loop; other site 1127744002926 ATP binding site [chemical binding]; other site 1127744002927 Q-loop/lid; other site 1127744002928 ABC transporter signature motif; other site 1127744002929 Walker B; other site 1127744002930 D-loop; other site 1127744002931 H-loop/switch region; other site 1127744002932 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1127744002933 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1127744002934 substrate binding pocket [chemical binding]; other site 1127744002935 membrane-bound complex binding site; other site 1127744002936 hinge residues; other site 1127744002937 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1127744002938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744002939 dimer interface [polypeptide binding]; other site 1127744002940 conserved gate region; other site 1127744002941 putative PBP binding loops; other site 1127744002942 ABC-ATPase subunit interface; other site 1127744002943 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1127744002944 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1127744002945 active site 1127744002946 dimer interface [polypeptide binding]; other site 1127744002947 non-prolyl cis peptide bond; other site 1127744002948 insertion regions; other site 1127744002949 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1127744002950 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127744002951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127744002952 non-specific DNA binding site [nucleotide binding]; other site 1127744002953 salt bridge; other site 1127744002954 sequence-specific DNA binding site [nucleotide binding]; other site 1127744002955 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1127744002956 epoxyqueuosine reductase; Region: TIGR00276 1127744002957 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1127744002958 Putative amidase domain; Region: Amidase_6; pfam12671 1127744002959 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 1127744002960 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1127744002961 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1127744002962 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1127744002963 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1127744002964 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1127744002965 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1127744002966 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744002967 MarR family; Region: MarR; pfam01047 1127744002968 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1127744002969 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1127744002970 carboxyltransferase (CT) interaction site; other site 1127744002971 biotinylation site [posttranslational modification]; other site 1127744002972 HlyD family secretion protein; Region: HlyD_3; pfam13437 1127744002973 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1127744002974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744002975 putative substrate translocation pore; other site 1127744002976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744002977 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1127744002978 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1127744002979 Predicted transcriptional regulators [Transcription]; Region: COG1725 1127744002980 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744002981 DNA-binding site [nucleotide binding]; DNA binding site 1127744002982 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1127744002983 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1127744002984 Walker A/P-loop; other site 1127744002985 ATP binding site [chemical binding]; other site 1127744002986 Q-loop/lid; other site 1127744002987 ABC transporter signature motif; other site 1127744002988 Walker B; other site 1127744002989 D-loop; other site 1127744002990 H-loop/switch region; other site 1127744002991 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1127744002992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1127744002993 Walker A/P-loop; other site 1127744002994 ATP binding site [chemical binding]; other site 1127744002995 Q-loop/lid; other site 1127744002996 ABC transporter signature motif; other site 1127744002997 Walker B; other site 1127744002998 D-loop; other site 1127744002999 H-loop/switch region; other site 1127744003000 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1127744003001 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1127744003002 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1127744003003 DNA-binding site [nucleotide binding]; DNA binding site 1127744003004 RNA-binding motif; other site 1127744003005 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1127744003006 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1127744003007 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1127744003008 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1127744003009 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1127744003010 metal binding site [ion binding]; metal-binding site 1127744003011 active site 1127744003012 I-site; other site 1127744003013 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1127744003014 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1127744003015 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1127744003016 Predicted transcriptional regulators [Transcription]; Region: COG1695 1127744003017 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1127744003018 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1127744003019 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1127744003020 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1127744003021 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1127744003022 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1127744003023 generic binding surface II; other site 1127744003024 generic binding surface I; other site 1127744003025 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1127744003026 generic binding surface II; other site 1127744003027 generic binding surface I; other site 1127744003028 Staphylococcal nuclease homologues; Region: SNc; smart00318 1127744003029 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1127744003030 Catalytic site; other site 1127744003031 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1127744003032 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1127744003033 putative active site [active] 1127744003034 putative metal binding site [ion binding]; other site 1127744003035 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1127744003036 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1127744003037 active site 1127744003038 catalytic site [active] 1127744003039 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1127744003040 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127744003041 RNA binding surface [nucleotide binding]; other site 1127744003042 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1127744003043 active site 1127744003044 FOG: CBS domain [General function prediction only]; Region: COG0517 1127744003045 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1127744003046 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1127744003047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744003048 motif II; other site 1127744003049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744003050 Coenzyme A binding pocket [chemical binding]; other site 1127744003051 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1127744003052 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1127744003053 putative active site [active] 1127744003054 catalytic triad [active] 1127744003055 putative dimer interface [polypeptide binding]; other site 1127744003056 aminotransferase; Validated; Region: PRK07678 1127744003057 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127744003058 inhibitor-cofactor binding pocket; inhibition site 1127744003059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744003060 catalytic residue [active] 1127744003061 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1127744003062 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1127744003063 amphipathic channel; other site 1127744003064 Asn-Pro-Ala signature motifs; other site 1127744003065 glycerol kinase; Provisional; Region: glpK; PRK00047 1127744003066 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1127744003067 N- and C-terminal domain interface [polypeptide binding]; other site 1127744003068 active site 1127744003069 MgATP binding site [chemical binding]; other site 1127744003070 catalytic site [active] 1127744003071 metal binding site [ion binding]; metal-binding site 1127744003072 glycerol binding site [chemical binding]; other site 1127744003073 homotetramer interface [polypeptide binding]; other site 1127744003074 homodimer interface [polypeptide binding]; other site 1127744003075 FBP binding site [chemical binding]; other site 1127744003076 protein IIAGlc interface [polypeptide binding]; other site 1127744003077 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1127744003078 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1127744003079 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1127744003080 active site 1127744003081 substrate binding site [chemical binding]; other site 1127744003082 metal binding site [ion binding]; metal-binding site 1127744003083 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1127744003084 GAF domain; Region: GAF; pfam01590 1127744003085 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127744003086 Histidine kinase; Region: HisKA_3; pfam07730 1127744003087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744003088 ATP binding site [chemical binding]; other site 1127744003089 Mg2+ binding site [ion binding]; other site 1127744003090 G-X-G motif; other site 1127744003091 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127744003092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744003093 active site 1127744003094 phosphorylation site [posttranslational modification] 1127744003095 intermolecular recognition site; other site 1127744003096 dimerization interface [polypeptide binding]; other site 1127744003097 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127744003098 DNA binding residues [nucleotide binding] 1127744003099 dimerization interface [polypeptide binding]; other site 1127744003100 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1127744003101 Predicted flavoprotein [General function prediction only]; Region: COG0431 1127744003102 YhdB-like protein; Region: YhdB; pfam14148 1127744003103 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1127744003104 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744003105 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744003106 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744003107 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744003108 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744003109 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1127744003110 NlpC/P60 family; Region: NLPC_P60; pfam00877 1127744003111 Transcriptional regulator; Region: Rrf2; cl17282 1127744003112 Rrf2 family protein; Region: rrf2_super; TIGR00738 1127744003113 Conserved TM helix; Region: TM_helix; pfam05552 1127744003114 Conserved TM helix; Region: TM_helix; pfam05552 1127744003115 Conserved TM helix; Region: TM_helix; pfam05552 1127744003116 Conserved TM helix; Region: TM_helix; pfam05552 1127744003117 Conserved TM helix; Region: TM_helix; pfam05552 1127744003118 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1127744003119 SpoVR like protein; Region: SpoVR; pfam04293 1127744003120 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1127744003121 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1127744003122 dimer interface [polypeptide binding]; other site 1127744003123 active site 1127744003124 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744003125 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744003126 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744003127 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1127744003128 NlpC/P60 family; Region: NLPC_P60; pfam00877 1127744003129 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744003130 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744003131 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1127744003132 dimerization interface [polypeptide binding]; other site 1127744003133 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1127744003134 dimer interface [polypeptide binding]; other site 1127744003135 Citrate synthase; Region: Citrate_synt; pfam00285 1127744003136 active site 1127744003137 citrylCoA binding site [chemical binding]; other site 1127744003138 oxalacetate/citrate binding site [chemical binding]; other site 1127744003139 coenzyme A binding site [chemical binding]; other site 1127744003140 catalytic triad [active] 1127744003141 short chain dehydrogenase; Provisional; Region: PRK06701 1127744003142 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1127744003143 NAD binding site [chemical binding]; other site 1127744003144 metal binding site [ion binding]; metal-binding site 1127744003145 active site 1127744003146 amino acid transporter; Region: 2A0306; TIGR00909 1127744003147 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1127744003148 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1127744003149 Na2 binding site [ion binding]; other site 1127744003150 putative substrate binding site 1 [chemical binding]; other site 1127744003151 Na binding site 1 [ion binding]; other site 1127744003152 putative substrate binding site 2 [chemical binding]; other site 1127744003153 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1127744003154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744003155 DNA-binding site [nucleotide binding]; DNA binding site 1127744003156 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127744003157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744003158 homodimer interface [polypeptide binding]; other site 1127744003159 catalytic residue [active] 1127744003160 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1127744003161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744003162 Coenzyme A binding pocket [chemical binding]; other site 1127744003163 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1127744003164 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1127744003165 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1127744003166 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744003167 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744003168 DNA binding residues [nucleotide binding] 1127744003169 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1127744003170 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1127744003171 active site 1127744003172 catalytic tetrad [active] 1127744003173 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1127744003174 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1127744003175 putative acyl-acceptor binding pocket; other site 1127744003176 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1127744003177 Domain of unknown function DUF21; Region: DUF21; pfam01595 1127744003178 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1127744003179 Transporter associated domain; Region: CorC_HlyC; smart01091 1127744003180 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1127744003181 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127744003182 DNA binding residues [nucleotide binding] 1127744003183 putative dimer interface [polypeptide binding]; other site 1127744003184 aspartate aminotransferase; Provisional; Region: PRK06836 1127744003185 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127744003186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744003187 homodimer interface [polypeptide binding]; other site 1127744003188 catalytic residue [active] 1127744003189 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1127744003190 Domain of unknown function DUF21; Region: DUF21; pfam01595 1127744003191 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1127744003192 Transporter associated domain; Region: CorC_HlyC; smart01091 1127744003193 camphor resistance protein CrcB; Provisional; Region: PRK14213 1127744003194 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1127744003195 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1127744003196 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1127744003197 active site 1127744003198 catalytic site [active] 1127744003199 metal binding site [ion binding]; metal-binding site 1127744003200 dimer interface [polypeptide binding]; other site 1127744003201 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1127744003202 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1127744003203 NAD-dependent deacetylase; Provisional; Region: PRK00481 1127744003204 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1127744003205 NAD+ binding site [chemical binding]; other site 1127744003206 substrate binding site [chemical binding]; other site 1127744003207 Zn binding site [ion binding]; other site 1127744003208 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1127744003209 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1127744003210 NodB motif; other site 1127744003211 active site 1127744003212 catalytic site [active] 1127744003213 Zn binding site [ion binding]; other site 1127744003214 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1127744003215 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1127744003216 homodimer interface [polypeptide binding]; other site 1127744003217 substrate-cofactor binding pocket; other site 1127744003218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744003219 catalytic residue [active] 1127744003220 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1127744003221 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1127744003222 Ligand Binding Site [chemical binding]; other site 1127744003223 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1127744003224 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1127744003225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1127744003226 Walker A/P-loop; other site 1127744003227 ATP binding site [chemical binding]; other site 1127744003228 Q-loop/lid; other site 1127744003229 ABC transporter signature motif; other site 1127744003230 Walker B; other site 1127744003231 D-loop; other site 1127744003232 H-loop/switch region; other site 1127744003233 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1127744003234 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127744003235 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1127744003236 Walker A/P-loop; other site 1127744003237 ATP binding site [chemical binding]; other site 1127744003238 Q-loop/lid; other site 1127744003239 ABC transporter signature motif; other site 1127744003240 Walker B; other site 1127744003241 D-loop; other site 1127744003242 H-loop/switch region; other site 1127744003243 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1127744003244 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1127744003245 NAD binding site [chemical binding]; other site 1127744003246 substrate binding site [chemical binding]; other site 1127744003247 putative active site [active] 1127744003248 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1127744003249 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1127744003250 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1127744003251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1127744003252 hypothetical protein; Provisional; Region: PRK13676 1127744003253 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1127744003254 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1127744003255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744003256 active site 1127744003257 motif I; other site 1127744003258 motif II; other site 1127744003259 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1127744003260 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1127744003261 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127744003262 FeS/SAM binding site; other site 1127744003263 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1127744003264 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1127744003265 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1127744003266 TrkA-C domain; Region: TrkA_C; pfam02080 1127744003267 enoyl-CoA hydratase; Provisional; Region: PRK07659 1127744003268 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127744003269 substrate binding site [chemical binding]; other site 1127744003270 oxyanion hole (OAH) forming residues; other site 1127744003271 trimer interface [polypeptide binding]; other site 1127744003272 YhzD-like protein; Region: YhzD; pfam14120 1127744003273 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1127744003274 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1127744003275 Walker A/P-loop; other site 1127744003276 ATP binding site [chemical binding]; other site 1127744003277 Q-loop/lid; other site 1127744003278 ABC transporter signature motif; other site 1127744003279 Walker B; other site 1127744003280 D-loop; other site 1127744003281 H-loop/switch region; other site 1127744003282 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1127744003283 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1127744003284 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1127744003285 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1127744003286 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1127744003287 active site 1127744003288 metal binding site [ion binding]; metal-binding site 1127744003289 DNA binding site [nucleotide binding] 1127744003290 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1127744003291 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1127744003292 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1127744003293 generic binding surface II; other site 1127744003294 generic binding surface I; other site 1127744003295 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1127744003296 Zn2+ binding site [ion binding]; other site 1127744003297 Mg2+ binding site [ion binding]; other site 1127744003298 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1127744003299 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1127744003300 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1127744003301 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1127744003302 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1127744003303 transcriptional regulator Hpr; Provisional; Region: PRK13777 1127744003304 MarR family; Region: MarR; pfam01047 1127744003305 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1127744003306 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1127744003307 homodimer interface [polypeptide binding]; other site 1127744003308 substrate-cofactor binding pocket; other site 1127744003309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744003310 catalytic residue [active] 1127744003311 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1127744003312 HIT family signature motif; other site 1127744003313 catalytic residue [active] 1127744003314 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1127744003315 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1127744003316 Walker A/P-loop; other site 1127744003317 ATP binding site [chemical binding]; other site 1127744003318 Q-loop/lid; other site 1127744003319 ABC transporter signature motif; other site 1127744003320 Walker B; other site 1127744003321 D-loop; other site 1127744003322 H-loop/switch region; other site 1127744003323 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1127744003324 EcsC protein family; Region: EcsC; pfam12787 1127744003325 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1127744003326 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1127744003327 metal binding site [ion binding]; metal-binding site 1127744003328 dimer interface [polypeptide binding]; other site 1127744003329 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1127744003330 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1127744003331 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1127744003332 Transglycosylase; Region: Transgly; pfam00912 1127744003333 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1127744003334 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1127744003335 substrate binding site [chemical binding]; other site 1127744003336 active site 1127744003337 ferrochelatase; Provisional; Region: PRK12435 1127744003338 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1127744003339 C-terminal domain interface [polypeptide binding]; other site 1127744003340 active site 1127744003341 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1127744003342 active site 1127744003343 N-terminal domain interface [polypeptide binding]; other site 1127744003344 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1127744003345 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1127744003346 SEA domain; Region: SEA; cl02507 1127744003347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744003348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744003349 Predicted membrane protein [Function unknown]; Region: COG1511 1127744003350 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1127744003351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744003352 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1127744003353 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1127744003354 dimer interface [polypeptide binding]; other site 1127744003355 active site 1127744003356 CoA binding pocket [chemical binding]; other site 1127744003357 Predicted membrane protein [Function unknown]; Region: COG4377 1127744003358 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1127744003359 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1127744003360 putative oligomer interface [polypeptide binding]; other site 1127744003361 putative active site [active] 1127744003362 metal binding site [ion binding]; metal-binding site 1127744003363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4405 1127744003364 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1127744003365 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1127744003366 YhfH-like protein; Region: YhfH; pfam14149 1127744003367 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1127744003368 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1127744003369 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1127744003370 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1127744003371 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1127744003372 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1127744003373 NAD(P) binding site [chemical binding]; other site 1127744003374 putative active site [active] 1127744003375 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1127744003376 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1127744003377 acyl-activating enzyme (AAE) consensus motif; other site 1127744003378 putative AMP binding site [chemical binding]; other site 1127744003379 putative active site [active] 1127744003380 putative CoA binding site [chemical binding]; other site 1127744003381 Peptidase family M48; Region: Peptidase_M48; pfam01435 1127744003382 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1127744003383 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1127744003384 active site 1127744003385 catalytic residues [active] 1127744003386 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1127744003387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744003388 Coenzyme A binding pocket [chemical binding]; other site 1127744003389 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1127744003390 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1127744003391 putative NADP binding site [chemical binding]; other site 1127744003392 putative dimer interface [polypeptide binding]; other site 1127744003393 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1127744003394 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1127744003395 siderophore binding site; other site 1127744003396 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1127744003397 catalytic core [active] 1127744003398 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1127744003399 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1127744003400 dimer interface [polypeptide binding]; other site 1127744003401 active site 1127744003402 acyl-CoA synthetase; Validated; Region: PRK07638 1127744003403 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1127744003404 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1127744003405 acyl-activating enzyme (AAE) consensus motif; other site 1127744003406 acyl-activating enzyme (AAE) consensus motif; other site 1127744003407 AMP binding site [chemical binding]; other site 1127744003408 active site 1127744003409 CoA binding site [chemical binding]; other site 1127744003410 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1127744003411 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1127744003412 heme-binding site [chemical binding]; other site 1127744003413 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1127744003414 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1127744003415 dimer interface [polypeptide binding]; other site 1127744003416 putative CheW interface [polypeptide binding]; other site 1127744003417 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1127744003418 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1127744003419 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1127744003420 [2Fe-2S] cluster binding site [ion binding]; other site 1127744003421 short chain dehydrogenase; Provisional; Region: PRK06701 1127744003422 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1127744003423 NAD binding site [chemical binding]; other site 1127744003424 metal binding site [ion binding]; metal-binding site 1127744003425 active site 1127744003426 IDEAL domain; Region: IDEAL; pfam08858 1127744003427 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1127744003428 oxidoreductase; Provisional; Region: PRK07985 1127744003429 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1127744003430 NAD binding site [chemical binding]; other site 1127744003431 metal binding site [ion binding]; metal-binding site 1127744003432 active site 1127744003433 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1127744003434 Na binding site [ion binding]; other site 1127744003435 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1127744003436 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1127744003437 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1127744003438 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1127744003439 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1127744003440 Catalytic site [active] 1127744003441 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1127744003442 hypothetical protein; Provisional; Region: PRK08244 1127744003443 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1127744003444 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744003445 MarR family; Region: MarR; pfam01047 1127744003446 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1127744003447 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1127744003448 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1127744003449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744003450 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744003451 putative substrate translocation pore; other site 1127744003452 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1127744003453 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1127744003454 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1127744003455 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1127744003456 dimerization interface [polypeptide binding]; other site 1127744003457 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1127744003458 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1127744003459 dinuclear metal binding motif [ion binding]; other site 1127744003460 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1127744003461 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1127744003462 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1127744003463 Part of AAA domain; Region: AAA_19; pfam13245 1127744003464 Family description; Region: UvrD_C_2; pfam13538 1127744003465 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1127744003466 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1127744003467 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1127744003468 active site 1127744003469 metal binding site [ion binding]; metal-binding site 1127744003470 DNA binding site [nucleotide binding] 1127744003471 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1127744003472 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1127744003473 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1127744003474 Walker A/P-loop; other site 1127744003475 ATP binding site [chemical binding]; other site 1127744003476 Q-loop/lid; other site 1127744003477 ABC transporter signature motif; other site 1127744003478 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1127744003479 ABC transporter signature motif; other site 1127744003480 Walker B; other site 1127744003481 D-loop; other site 1127744003482 H-loop/switch region; other site 1127744003483 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1127744003484 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1127744003485 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1127744003486 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1127744003487 Spore germination protein GerPC; Region: GerPC; pfam10737 1127744003488 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1127744003489 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1127744003490 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1127744003491 CotH protein; Region: CotH; pfam08757 1127744003492 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1127744003493 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1127744003494 hypothetical protein; Provisional; Region: PRK13673 1127744003495 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1127744003496 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1127744003497 active site 1127744003498 catalytic triad [active] 1127744003499 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1127744003500 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1127744003501 active site 1127744003502 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1127744003503 dimer interface [polypeptide binding]; other site 1127744003504 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1127744003505 Ligand Binding Site [chemical binding]; other site 1127744003506 Molecular Tunnel; other site 1127744003507 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1127744003508 substrate binding pocket [chemical binding]; other site 1127744003509 aspartate-rich region 2; other site 1127744003510 substrate-Mg2+ binding site; other site 1127744003511 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1127744003512 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1127744003513 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1127744003514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127744003515 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127744003516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127744003517 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1127744003518 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1127744003519 DNA binding site [nucleotide binding] 1127744003520 domain linker motif; other site 1127744003521 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1127744003522 dimerization interface [polypeptide binding]; other site 1127744003523 ligand binding site [chemical binding]; other site 1127744003524 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1127744003525 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1127744003526 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1127744003527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1127744003528 Lysine efflux permease [General function prediction only]; Region: COG1279 1127744003529 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1127744003530 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1127744003531 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1127744003532 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1127744003533 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1127744003534 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1127744003535 ligand-binding site [chemical binding]; other site 1127744003536 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1127744003537 ATP-sulfurylase; Region: ATPS; cd00517 1127744003538 active site 1127744003539 HXXH motif; other site 1127744003540 flexible loop; other site 1127744003541 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1127744003542 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1127744003543 Active Sites [active] 1127744003544 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1127744003545 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 1127744003546 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 1127744003547 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1127744003548 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127744003549 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1127744003550 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1127744003551 active site pocket [active] 1127744003552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744003553 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744003554 putative substrate translocation pore; other site 1127744003555 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1127744003556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744003557 Coenzyme A binding pocket [chemical binding]; other site 1127744003558 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1127744003559 Coenzyme A binding pocket [chemical binding]; other site 1127744003560 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1127744003561 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1127744003562 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1127744003563 FAD binding site [chemical binding]; other site 1127744003564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1127744003565 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1127744003566 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1127744003567 S1 domain; Region: S1_2; pfam13509 1127744003568 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1127744003569 RNA binding site [nucleotide binding]; other site 1127744003570 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1127744003571 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1127744003572 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 1127744003573 Predicted transcriptional regulators [Transcription]; Region: COG1695 1127744003574 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1127744003575 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1127744003576 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1127744003577 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1127744003578 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1127744003579 active site 1127744003580 Zn binding site [ion binding]; other site 1127744003581 EDD domain protein, DegV family; Region: DegV; TIGR00762 1127744003582 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1127744003583 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1127744003584 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127744003585 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127744003586 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1127744003587 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1127744003588 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1127744003589 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1127744003590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744003591 motif II; other site 1127744003592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744003593 esterase; Provisional; Region: PRK10566 1127744003594 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1127744003595 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1127744003596 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1127744003597 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1127744003598 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1127744003599 FAD binding domain; Region: FAD_binding_4; pfam01565 1127744003600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744003601 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744003602 putative substrate translocation pore; other site 1127744003603 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1127744003604 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1127744003605 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1127744003606 heterotetramer interface [polypeptide binding]; other site 1127744003607 active site pocket [active] 1127744003608 cleavage site 1127744003609 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1127744003610 nucleotide binding site [chemical binding]; other site 1127744003611 N-acetyl-L-glutamate binding site [chemical binding]; other site 1127744003612 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1127744003613 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127744003614 inhibitor-cofactor binding pocket; inhibition site 1127744003615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744003616 catalytic residue [active] 1127744003617 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1127744003618 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1127744003619 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1127744003620 catalytic site [active] 1127744003621 subunit interface [polypeptide binding]; other site 1127744003622 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1127744003623 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127744003624 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1127744003625 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1127744003626 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127744003627 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1127744003628 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1127744003629 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1127744003630 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1127744003631 YjzC-like protein; Region: YjzC; pfam14168 1127744003632 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1127744003633 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1127744003634 UDP-apiose/xylose synthase; Region: PLN02427 1127744003635 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1127744003636 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1127744003637 putative ligand binding site [chemical binding]; other site 1127744003638 ComZ; Region: ComZ; pfam10815 1127744003639 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1127744003640 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1127744003641 dimer interface [polypeptide binding]; other site 1127744003642 active site 1127744003643 CoA binding pocket [chemical binding]; other site 1127744003644 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1127744003645 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1127744003646 dimer interface [polypeptide binding]; other site 1127744003647 active site 1127744003648 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1127744003649 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1127744003650 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1127744003651 Walker A/P-loop; other site 1127744003652 ATP binding site [chemical binding]; other site 1127744003653 Q-loop/lid; other site 1127744003654 ABC transporter signature motif; other site 1127744003655 Walker B; other site 1127744003656 D-loop; other site 1127744003657 H-loop/switch region; other site 1127744003658 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1127744003659 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1127744003660 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1127744003661 Walker A/P-loop; other site 1127744003662 ATP binding site [chemical binding]; other site 1127744003663 Q-loop/lid; other site 1127744003664 ABC transporter signature motif; other site 1127744003665 Walker B; other site 1127744003666 D-loop; other site 1127744003667 H-loop/switch region; other site 1127744003668 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1127744003669 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1127744003670 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1127744003671 peptide binding site [polypeptide binding]; other site 1127744003672 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1127744003673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744003674 dimer interface [polypeptide binding]; other site 1127744003675 conserved gate region; other site 1127744003676 putative PBP binding loops; other site 1127744003677 ABC-ATPase subunit interface; other site 1127744003678 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1127744003679 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1127744003680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744003681 dimer interface [polypeptide binding]; other site 1127744003682 conserved gate region; other site 1127744003683 putative PBP binding loops; other site 1127744003684 ABC-ATPase subunit interface; other site 1127744003685 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1127744003686 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1127744003687 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1127744003688 active site 1127744003689 HIGH motif; other site 1127744003690 dimer interface [polypeptide binding]; other site 1127744003691 KMSKS motif; other site 1127744003692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1127744003693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744003694 dimer interface [polypeptide binding]; other site 1127744003695 conserved gate region; other site 1127744003696 putative PBP binding loops; other site 1127744003697 ABC-ATPase subunit interface; other site 1127744003698 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1127744003699 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1127744003700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744003701 dimer interface [polypeptide binding]; other site 1127744003702 conserved gate region; other site 1127744003703 putative PBP binding loops; other site 1127744003704 ABC-ATPase subunit interface; other site 1127744003705 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1127744003706 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1127744003707 Walker A/P-loop; other site 1127744003708 ATP binding site [chemical binding]; other site 1127744003709 Q-loop/lid; other site 1127744003710 ABC transporter signature motif; other site 1127744003711 Walker B; other site 1127744003712 D-loop; other site 1127744003713 H-loop/switch region; other site 1127744003714 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1127744003715 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1127744003716 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1127744003717 Walker A/P-loop; other site 1127744003718 ATP binding site [chemical binding]; other site 1127744003719 Q-loop/lid; other site 1127744003720 ABC transporter signature motif; other site 1127744003721 Walker B; other site 1127744003722 D-loop; other site 1127744003723 H-loop/switch region; other site 1127744003724 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1127744003725 H+ Antiporter protein; Region: 2A0121; TIGR00900 1127744003726 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1127744003727 ArsC family; Region: ArsC; pfam03960 1127744003728 putative catalytic residues [active] 1127744003729 thiol/disulfide switch; other site 1127744003730 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1127744003731 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 1127744003732 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 1127744003733 oligoendopeptidase F; Region: pepF; TIGR00181 1127744003734 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1127744003735 active site 1127744003736 Zn binding site [ion binding]; other site 1127744003737 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1127744003738 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1127744003739 catalytic residues [active] 1127744003740 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1127744003741 apolar tunnel; other site 1127744003742 heme binding site [chemical binding]; other site 1127744003743 dimerization interface [polypeptide binding]; other site 1127744003744 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1127744003745 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1127744003746 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1127744003747 catalytic residue [active] 1127744003748 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1127744003749 putative active site [active] 1127744003750 putative metal binding residues [ion binding]; other site 1127744003751 signature motif; other site 1127744003752 putative triphosphate binding site [ion binding]; other site 1127744003753 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1127744003754 synthetase active site [active] 1127744003755 NTP binding site [chemical binding]; other site 1127744003756 metal binding site [ion binding]; metal-binding site 1127744003757 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1127744003758 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1127744003759 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1127744003760 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1127744003761 active site 1127744003762 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1127744003763 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1127744003764 active site 1127744003765 metal binding site [ion binding]; metal-binding site 1127744003766 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1127744003767 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1127744003768 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1127744003769 TrkA-N domain; Region: TrkA_N; pfam02254 1127744003770 TrkA-C domain; Region: TrkA_C; pfam02080 1127744003771 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1127744003772 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1127744003773 thiamine phosphate binding site [chemical binding]; other site 1127744003774 active site 1127744003775 pyrophosphate binding site [ion binding]; other site 1127744003776 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1127744003777 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1127744003778 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1127744003779 thiS-thiF/thiG interaction site; other site 1127744003780 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1127744003781 ThiS interaction site; other site 1127744003782 putative active site [active] 1127744003783 tetramer interface [polypeptide binding]; other site 1127744003784 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1127744003785 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1127744003786 ATP binding site [chemical binding]; other site 1127744003787 substrate interface [chemical binding]; other site 1127744003788 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1127744003789 dimer interface [polypeptide binding]; other site 1127744003790 substrate binding site [chemical binding]; other site 1127744003791 ATP binding site [chemical binding]; other site 1127744003792 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1127744003793 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1127744003794 NAD binding site [chemical binding]; other site 1127744003795 homotetramer interface [polypeptide binding]; other site 1127744003796 homodimer interface [polypeptide binding]; other site 1127744003797 substrate binding site [chemical binding]; other site 1127744003798 active site 1127744003799 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1127744003800 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1127744003801 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1127744003802 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1127744003803 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1127744003804 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1127744003805 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1127744003806 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1127744003807 Part of AAA domain; Region: AAA_19; pfam13245 1127744003808 Family description; Region: UvrD_C_2; pfam13538 1127744003809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744003810 Coenzyme A binding pocket [chemical binding]; other site 1127744003811 hypothetical protein; Provisional; Region: PRK13679 1127744003812 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1127744003813 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1127744003814 Putative esterase; Region: Esterase; pfam00756 1127744003815 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1127744003816 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1127744003817 homodimer interface [polypeptide binding]; other site 1127744003818 substrate-cofactor binding pocket; other site 1127744003819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744003820 catalytic residue [active] 1127744003821 cystathionine beta-lyase; Provisional; Region: PRK08064 1127744003822 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1127744003823 homodimer interface [polypeptide binding]; other site 1127744003824 substrate-cofactor binding pocket; other site 1127744003825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744003826 catalytic residue [active] 1127744003827 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1127744003828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1127744003829 Predicted integral membrane protein [Function unknown]; Region: COG5505 1127744003830 LXG domain of WXG superfamily; Region: LXG; pfam04740 1127744003831 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1127744003832 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1127744003833 HTH domain; Region: HTH_11; pfam08279 1127744003834 PRD domain; Region: PRD; pfam00874 1127744003835 PRD domain; Region: PRD; pfam00874 1127744003836 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1127744003837 active site 1127744003838 P-loop; other site 1127744003839 phosphorylation site [posttranslational modification] 1127744003840 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1127744003841 active site 1127744003842 phosphorylation site [posttranslational modification] 1127744003843 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1127744003844 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1127744003845 active site 1127744003846 P-loop; other site 1127744003847 phosphorylation site [posttranslational modification] 1127744003848 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1127744003849 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1127744003850 active site 1127744003851 phosphorylation site [posttranslational modification] 1127744003852 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1127744003853 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1127744003854 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1127744003855 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1127744003856 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1127744003857 Coenzyme A binding pocket [chemical binding]; other site 1127744003858 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1127744003859 putative deacylase active site [active] 1127744003860 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1127744003861 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1127744003862 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 1127744003863 UbiA prenyltransferase family; Region: UbiA; pfam01040 1127744003864 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1127744003865 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1127744003866 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1127744003867 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 1127744003868 NodB motif; other site 1127744003869 active site 1127744003870 catalytic site [active] 1127744003871 Zn binding site [ion binding]; other site 1127744003872 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1127744003873 Putative motility protein; Region: YjfB_motility; pfam14070 1127744003874 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1127744003875 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1127744003876 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1127744003877 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1127744003878 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1127744003879 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1127744003880 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1127744003881 4Fe-4S binding domain; Region: Fer4; pfam00037 1127744003882 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1127744003883 [4Fe-4S] binding site [ion binding]; other site 1127744003884 molybdopterin cofactor binding site; other site 1127744003885 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1127744003886 molybdopterin cofactor binding site; other site 1127744003887 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1127744003888 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1127744003889 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1127744003890 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1127744003891 nudix motif; other site 1127744003892 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1127744003893 Cytochrome P450; Region: p450; cl12078 1127744003894 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1127744003895 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1127744003896 active site 1127744003897 TDP-binding site; other site 1127744003898 acceptor substrate-binding pocket; other site 1127744003899 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1127744003900 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1127744003901 active site 1127744003902 TIGR00245 family protein; Region: TIGR00245 1127744003903 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1127744003904 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1127744003905 Walker A/P-loop; other site 1127744003906 ATP binding site [chemical binding]; other site 1127744003907 Q-loop/lid; other site 1127744003908 ABC transporter signature motif; other site 1127744003909 Walker B; other site 1127744003910 D-loop; other site 1127744003911 H-loop/switch region; other site 1127744003912 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1127744003913 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1127744003914 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1127744003915 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1127744003916 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127744003917 Glucuronate isomerase; Region: UxaC; pfam02614 1127744003918 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1127744003919 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1127744003920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744003921 putative substrate translocation pore; other site 1127744003922 Malate/L-lactate dehydrogenase; Region: Ldh_2; pfam02615 1127744003923 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1127744003924 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1127744003925 putative NAD(P) binding site [chemical binding]; other site 1127744003926 catalytic Zn binding site [ion binding]; other site 1127744003927 structural Zn binding site [ion binding]; other site 1127744003928 mannonate dehydratase; Provisional; Region: PRK03906 1127744003929 mannonate dehydratase; Region: uxuA; TIGR00695 1127744003930 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1127744003931 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1127744003932 putative NAD(P) binding site [chemical binding]; other site 1127744003933 active site 1127744003934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744003935 D-galactonate transporter; Region: 2A0114; TIGR00893 1127744003936 putative substrate translocation pore; other site 1127744003937 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1127744003938 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1127744003939 DNA binding site [nucleotide binding] 1127744003940 domain linker motif; other site 1127744003941 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1127744003942 dimerization interface [polypeptide binding]; other site 1127744003943 ligand binding site [chemical binding]; other site 1127744003944 altronate oxidoreductase; Provisional; Region: PRK03643 1127744003945 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1127744003946 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1127744003947 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1127744003948 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1127744003949 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1127744003950 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1127744003951 DinB family; Region: DinB; pfam05163 1127744003952 DinB superfamily; Region: DinB_2; pfam12867 1127744003953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744003954 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1127744003955 Walker A motif; other site 1127744003956 ATP binding site [chemical binding]; other site 1127744003957 Walker B motif; other site 1127744003958 arginine finger; other site 1127744003959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744003960 binding surface 1127744003961 TPR motif; other site 1127744003962 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744003963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744003964 binding surface 1127744003965 TPR motif; other site 1127744003966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1127744003967 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1127744003968 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1127744003969 amidase catalytic site [active] 1127744003970 Zn binding residues [ion binding]; other site 1127744003971 substrate binding site [chemical binding]; other site 1127744003972 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1127744003973 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744003974 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1127744003975 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1127744003976 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1127744003977 pentamer interface [polypeptide binding]; other site 1127744003978 dodecaamer interface [polypeptide binding]; other site 1127744003979 Phage-related replication protein [General function prediction only]; Region: COG4195 1127744003980 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1127744003981 dimanganese center [ion binding]; other site 1127744003982 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1127744003983 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127744003984 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127744003985 non-specific DNA binding site [nucleotide binding]; other site 1127744003986 salt bridge; other site 1127744003987 sequence-specific DNA binding site [nucleotide binding]; other site 1127744003988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744003989 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1127744003990 Walker A motif; other site 1127744003991 ATP binding site [chemical binding]; other site 1127744003992 Walker B motif; other site 1127744003993 arginine finger; other site 1127744003994 positive control sigma-like factor; Validated; Region: PRK06930 1127744003995 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744003996 DNA binding residues [nucleotide binding] 1127744003997 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1127744003998 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1127744003999 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 1127744004000 Terminase-like family; Region: Terminase_6; pfam03237 1127744004001 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 1127744004002 Phage capsid family; Region: Phage_capsid; pfam05065 1127744004003 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 1127744004004 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1127744004005 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1127744004006 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1127744004007 Phage XkdN-like protein; Region: XkdN; pfam08890 1127744004008 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1127744004009 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1127744004010 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1127744004011 catalytic residue [active] 1127744004012 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1127744004013 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744004014 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 1127744004015 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1127744004016 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1127744004017 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1127744004018 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1127744004019 XkdW protein; Region: XkdW; pfam09636 1127744004020 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1127744004021 Haemolysin XhlA; Region: XhlA; pfam10779 1127744004022 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1127744004023 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1127744004024 amidase catalytic site [active] 1127744004025 Zn binding residues [ion binding]; other site 1127744004026 substrate binding site [chemical binding]; other site 1127744004027 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744004028 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1127744004029 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1127744004030 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1127744004031 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1127744004032 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1127744004033 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1127744004034 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1127744004035 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1127744004036 Zn binding site [ion binding]; other site 1127744004037 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1127744004038 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127744004039 Zn binding site [ion binding]; other site 1127744004040 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1127744004041 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1127744004042 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1127744004043 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1127744004044 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1127744004045 Ligand binding site; other site 1127744004046 Putative Catalytic site; other site 1127744004047 DXD motif; other site 1127744004048 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1127744004049 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1127744004050 protein binding site [polypeptide binding]; other site 1127744004051 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 1127744004052 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1127744004053 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1127744004054 SxDxEG motif; other site 1127744004055 active site 1127744004056 metal binding site [ion binding]; metal-binding site 1127744004057 homopentamer interface [polypeptide binding]; other site 1127744004058 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1127744004059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744004060 dimer interface [polypeptide binding]; other site 1127744004061 conserved gate region; other site 1127744004062 putative PBP binding loops; other site 1127744004063 ABC-ATPase subunit interface; other site 1127744004064 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1127744004065 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1127744004066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744004067 putative PBP binding loops; other site 1127744004068 dimer interface [polypeptide binding]; other site 1127744004069 ABC-ATPase subunit interface; other site 1127744004070 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1127744004071 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1127744004072 Walker A/P-loop; other site 1127744004073 ATP binding site [chemical binding]; other site 1127744004074 Q-loop/lid; other site 1127744004075 ABC transporter signature motif; other site 1127744004076 Walker B; other site 1127744004077 D-loop; other site 1127744004078 H-loop/switch region; other site 1127744004079 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1127744004080 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1127744004081 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1127744004082 peptide binding site [polypeptide binding]; other site 1127744004083 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1127744004084 dimer interface [polypeptide binding]; other site 1127744004085 catalytic triad [active] 1127744004086 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1127744004087 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1127744004088 active site 1127744004089 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1127744004090 NlpC/P60 family; Region: NLPC_P60; pfam00877 1127744004091 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1127744004092 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1127744004093 Walker A/P-loop; other site 1127744004094 ATP binding site [chemical binding]; other site 1127744004095 Q-loop/lid; other site 1127744004096 ABC transporter signature motif; other site 1127744004097 Walker B; other site 1127744004098 D-loop; other site 1127744004099 H-loop/switch region; other site 1127744004100 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1127744004101 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1127744004102 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1127744004103 Amidinotransferase; Region: Amidinotransf; pfam02274 1127744004104 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1127744004105 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1127744004106 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1127744004107 heme-binding site [chemical binding]; other site 1127744004108 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1127744004109 FAD binding pocket [chemical binding]; other site 1127744004110 FAD binding motif [chemical binding]; other site 1127744004111 phosphate binding motif [ion binding]; other site 1127744004112 beta-alpha-beta structure motif; other site 1127744004113 NAD binding pocket [chemical binding]; other site 1127744004114 Heme binding pocket [chemical binding]; other site 1127744004115 Predicted membrane protein [Function unknown]; Region: COG2323 1127744004116 DinB superfamily; Region: DinB_2; pfam12867 1127744004117 metal-dependent hydrolase; Provisional; Region: PRK13291 1127744004118 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1127744004119 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1127744004120 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1127744004121 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1127744004122 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1127744004123 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1127744004124 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1127744004125 putative active site [active] 1127744004126 putative substrate binding site [chemical binding]; other site 1127744004127 putative cosubstrate binding site; other site 1127744004128 catalytic site [active] 1127744004129 glutamate 5-kinase; Region: proB; TIGR01027 1127744004130 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1127744004131 nucleotide binding site [chemical binding]; other site 1127744004132 homotetrameric interface [polypeptide binding]; other site 1127744004133 putative phosphate binding site [ion binding]; other site 1127744004134 putative allosteric binding site; other site 1127744004135 PUA domain; Region: PUA; pfam01472 1127744004136 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1127744004137 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1127744004138 putative catalytic cysteine [active] 1127744004139 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1127744004140 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744004141 MarR family; Region: MarR; pfam01047 1127744004142 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1127744004143 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1127744004144 nucleoside/Zn binding site; other site 1127744004145 dimer interface [polypeptide binding]; other site 1127744004146 catalytic motif [active] 1127744004147 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1127744004148 catalytic core [active] 1127744004149 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1127744004150 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 1127744004151 THF binding site; other site 1127744004152 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1127744004153 substrate binding site [chemical binding]; other site 1127744004154 THF binding site; other site 1127744004155 zinc-binding site [ion binding]; other site 1127744004156 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1127744004157 active site 1127744004158 catalytic residues [active] 1127744004159 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1127744004160 Cobalt transport protein; Region: CbiQ; pfam02361 1127744004161 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1127744004162 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1127744004163 Walker A/P-loop; other site 1127744004164 ATP binding site [chemical binding]; other site 1127744004165 Q-loop/lid; other site 1127744004166 ABC transporter signature motif; other site 1127744004167 Walker B; other site 1127744004168 D-loop; other site 1127744004169 H-loop/switch region; other site 1127744004170 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1127744004171 Walker A/P-loop; other site 1127744004172 ATP binding site [chemical binding]; other site 1127744004173 Q-loop/lid; other site 1127744004174 ABC transporter signature motif; other site 1127744004175 Walker B; other site 1127744004176 D-loop; other site 1127744004177 H-loop/switch region; other site 1127744004178 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 1127744004179 YKOF-related Family; Region: Ykof; pfam07615 1127744004180 YKOF-related Family; Region: Ykof; pfam07615 1127744004181 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127744004182 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744004183 active site 1127744004184 phosphorylation site [posttranslational modification] 1127744004185 intermolecular recognition site; other site 1127744004186 dimerization interface [polypeptide binding]; other site 1127744004187 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127744004188 DNA binding site [nucleotide binding] 1127744004189 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744004190 dimerization interface [polypeptide binding]; other site 1127744004191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1127744004192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744004193 dimer interface [polypeptide binding]; other site 1127744004194 phosphorylation site [posttranslational modification] 1127744004195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744004196 ATP binding site [chemical binding]; other site 1127744004197 Mg2+ binding site [ion binding]; other site 1127744004198 G-X-G motif; other site 1127744004199 Predicted membrane protein [Function unknown]; Region: COG3212 1127744004200 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1127744004201 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1127744004202 MgtE intracellular N domain; Region: MgtE_N; smart00924 1127744004203 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1127744004204 Divalent cation transporter; Region: MgtE; pfam01769 1127744004205 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1127744004206 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1127744004207 DNA binding residues [nucleotide binding] 1127744004208 putative dimer interface [polypeptide binding]; other site 1127744004209 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744004210 MarR family; Region: MarR; pfam01047 1127744004211 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 1127744004212 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1127744004213 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1127744004214 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1127744004215 putative active site [active] 1127744004216 putative metal binding site [ion binding]; other site 1127744004217 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1127744004218 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 1127744004219 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1127744004220 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1127744004221 Ligand binding site; other site 1127744004222 Putative Catalytic site; other site 1127744004223 DXD motif; other site 1127744004224 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1127744004225 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1127744004226 active site 1127744004227 DNA binding site [nucleotide binding] 1127744004228 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1127744004229 nucleotide binding site [chemical binding]; other site 1127744004230 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1127744004231 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1127744004232 putative DNA binding site [nucleotide binding]; other site 1127744004233 putative homodimer interface [polypeptide binding]; other site 1127744004234 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1127744004235 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1127744004236 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1127744004237 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1127744004238 PAS domain S-box; Region: sensory_box; TIGR00229 1127744004239 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1127744004240 metal binding site [ion binding]; metal-binding site 1127744004241 active site 1127744004242 I-site; other site 1127744004243 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1127744004244 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1127744004245 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1127744004246 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1127744004247 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1127744004248 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744004249 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1127744004250 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1127744004251 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1127744004252 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1127744004253 heat shock protein HtpX; Provisional; Region: PRK05457 1127744004254 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1127744004255 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1127744004256 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1127744004257 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1127744004258 putative active site [active] 1127744004259 heme pocket [chemical binding]; other site 1127744004260 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1127744004261 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1127744004262 putative active site [active] 1127744004263 heme pocket [chemical binding]; other site 1127744004264 PAS domain; Region: PAS; smart00091 1127744004265 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1127744004266 PAS domain; Region: PAS; smart00091 1127744004267 putative active site [active] 1127744004268 heme pocket [chemical binding]; other site 1127744004269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744004270 dimer interface [polypeptide binding]; other site 1127744004271 phosphorylation site [posttranslational modification] 1127744004272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744004273 ATP binding site [chemical binding]; other site 1127744004274 Mg2+ binding site [ion binding]; other site 1127744004275 G-X-G motif; other site 1127744004276 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1127744004277 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1127744004278 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1127744004279 DNA binding site [nucleotide binding] 1127744004280 active site 1127744004281 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1127744004282 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 1127744004283 Predicted kinase [General function prediction only]; Region: COG4857 1127744004284 Phosphotransferase enzyme family; Region: APH; pfam01636 1127744004285 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1127744004286 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1127744004287 putative active site [active] 1127744004288 catalytic triad [active] 1127744004289 putative dimer interface [polypeptide binding]; other site 1127744004290 transaminase; Reviewed; Region: PRK08068 1127744004291 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127744004292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744004293 homodimer interface [polypeptide binding]; other site 1127744004294 catalytic residue [active] 1127744004295 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 1127744004296 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1127744004297 dimer interface [polypeptide binding]; other site 1127744004298 active site 1127744004299 catalytic residue [active] 1127744004300 metal binding site [ion binding]; metal-binding site 1127744004301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744004302 motif II; other site 1127744004303 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1127744004304 intersubunit interface [polypeptide binding]; other site 1127744004305 active site 1127744004306 Zn2+ binding site [ion binding]; other site 1127744004307 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1127744004308 Cupin domain; Region: Cupin_2; pfam07883 1127744004309 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1127744004310 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1127744004311 Cache domain; Region: Cache_1; pfam02743 1127744004312 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1127744004313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744004314 dimer interface [polypeptide binding]; other site 1127744004315 phosphorylation site [posttranslational modification] 1127744004316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744004317 ATP binding site [chemical binding]; other site 1127744004318 Mg2+ binding site [ion binding]; other site 1127744004319 G-X-G motif; other site 1127744004320 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744004321 MarR family; Region: MarR; pfam01047 1127744004322 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1127744004323 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1127744004324 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1127744004325 ligand binding site [chemical binding]; other site 1127744004326 flagellar motor protein MotA; Validated; Region: PRK08124 1127744004327 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1127744004328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744004329 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1127744004330 Walker A motif; other site 1127744004331 ATP binding site [chemical binding]; other site 1127744004332 Walker B motif; other site 1127744004333 arginine finger; other site 1127744004334 UvrB/uvrC motif; Region: UVR; pfam02151 1127744004335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744004336 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1127744004337 Walker A motif; other site 1127744004338 ATP binding site [chemical binding]; other site 1127744004339 Walker B motif; other site 1127744004340 arginine finger; other site 1127744004341 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1127744004342 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1127744004343 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1127744004344 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1127744004345 Ligand Binding Site [chemical binding]; other site 1127744004346 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 1127744004347 active site 1127744004348 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1127744004349 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127744004350 FeS/SAM binding site; other site 1127744004351 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127744004352 non-specific DNA binding site [nucleotide binding]; other site 1127744004353 salt bridge; other site 1127744004354 sequence-specific DNA binding site [nucleotide binding]; other site 1127744004355 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1127744004356 nucleophilic elbow; other site 1127744004357 catalytic triad; other site 1127744004358 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1127744004359 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1127744004360 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1127744004361 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1127744004362 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1127744004363 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1127744004364 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1127744004365 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1127744004366 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1127744004367 catalytic residues [active] 1127744004368 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1127744004369 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1127744004370 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744004371 motif II; other site 1127744004372 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1127744004373 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1127744004374 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1127744004375 active site 1127744004376 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1127744004377 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1127744004378 DNA binding site [nucleotide binding] 1127744004379 domain linker motif; other site 1127744004380 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1127744004381 putative dimerization interface [polypeptide binding]; other site 1127744004382 putative ligand binding site [chemical binding]; other site 1127744004383 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1127744004384 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1127744004385 PRD domain; Region: PRD; pfam00874 1127744004386 PRD domain; Region: PRD; pfam00874 1127744004387 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1127744004388 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1127744004389 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1127744004390 active site turn [active] 1127744004391 phosphorylation site [posttranslational modification] 1127744004392 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1127744004393 HPr interaction site; other site 1127744004394 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1127744004395 active site 1127744004396 phosphorylation site [posttranslational modification] 1127744004397 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1127744004398 dimerization domain swap beta strand [polypeptide binding]; other site 1127744004399 regulatory protein interface [polypeptide binding]; other site 1127744004400 active site 1127744004401 regulatory phosphorylation site [posttranslational modification]; other site 1127744004402 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1127744004403 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1127744004404 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1127744004405 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1127744004406 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1127744004407 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1127744004408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127744004409 FeS/SAM binding site; other site 1127744004410 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1127744004411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744004412 Coenzyme A binding pocket [chemical binding]; other site 1127744004413 Cache domain; Region: Cache_1; pfam02743 1127744004414 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744004415 dimerization interface [polypeptide binding]; other site 1127744004416 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1127744004417 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1127744004418 dimer interface [polypeptide binding]; other site 1127744004419 putative CheW interface [polypeptide binding]; other site 1127744004420 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 1127744004421 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1127744004422 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1127744004423 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1127744004424 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1127744004425 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1127744004426 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1127744004427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1127744004428 putative active site [active] 1127744004429 heme pocket [chemical binding]; other site 1127744004430 PAS fold; Region: PAS; pfam00989 1127744004431 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1127744004432 putative active site [active] 1127744004433 heme pocket [chemical binding]; other site 1127744004434 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1127744004435 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1127744004436 putative active site [active] 1127744004437 heme pocket [chemical binding]; other site 1127744004438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744004439 dimer interface [polypeptide binding]; other site 1127744004440 phosphorylation site [posttranslational modification] 1127744004441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744004442 ATP binding site [chemical binding]; other site 1127744004443 Mg2+ binding site [ion binding]; other site 1127744004444 G-X-G motif; other site 1127744004445 aminotransferase A; Validated; Region: PRK07683 1127744004446 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127744004447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744004448 homodimer interface [polypeptide binding]; other site 1127744004449 catalytic residue [active] 1127744004450 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1127744004451 putative CheA interaction surface; other site 1127744004452 Response regulator receiver domain; Region: Response_reg; pfam00072 1127744004453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744004454 active site 1127744004455 phosphorylation site [posttranslational modification] 1127744004456 intermolecular recognition site; other site 1127744004457 dimerization interface [polypeptide binding]; other site 1127744004458 YkyB-like protein; Region: YkyB; pfam14177 1127744004459 H+ Antiporter protein; Region: 2A0121; TIGR00900 1127744004460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744004461 putative substrate translocation pore; other site 1127744004462 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744004463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1127744004464 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1127744004465 phosphodiesterase YaeI; Provisional; Region: PRK11340 1127744004466 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1127744004467 putative active site [active] 1127744004468 putative metal binding site [ion binding]; other site 1127744004469 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1127744004470 short chain dehydrogenase; Provisional; Region: PRK07677 1127744004471 NAD(P) binding site [chemical binding]; other site 1127744004472 substrate binding site [chemical binding]; other site 1127744004473 homotetramer interface [polypeptide binding]; other site 1127744004474 active site 1127744004475 homodimer interface [polypeptide binding]; other site 1127744004476 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1127744004477 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1127744004478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 1127744004479 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1127744004480 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1127744004481 FOG: CBS domain [General function prediction only]; Region: COG0517 1127744004482 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1127744004483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744004484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744004485 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1127744004486 dimerization interface [polypeptide binding]; other site 1127744004487 flavodoxin; Provisional; Region: PRK06703 1127744004488 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1127744004489 flavodoxin, short chain; Region: flav_short; TIGR01753 1127744004490 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1127744004491 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1127744004492 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1127744004493 active site 1127744004494 trimer interface [polypeptide binding]; other site 1127744004495 substrate binding site [chemical binding]; other site 1127744004496 CoA binding site [chemical binding]; other site 1127744004497 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1127744004498 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1127744004499 metal binding site [ion binding]; metal-binding site 1127744004500 putative dimer interface [polypeptide binding]; other site 1127744004501 hypothetical protein; Provisional; Region: PRK03094 1127744004502 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1127744004503 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1127744004504 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1127744004505 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1127744004506 dimer interface [polypeptide binding]; other site 1127744004507 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1127744004508 catalytic triad [active] 1127744004509 peroxidatic and resolving cysteines [active] 1127744004510 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1127744004511 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1127744004512 catalytic residues [active] 1127744004513 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1127744004514 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1127744004515 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1127744004516 GTP binding site; other site 1127744004517 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1127744004518 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1127744004519 ATP binding site [chemical binding]; other site 1127744004520 substrate interface [chemical binding]; other site 1127744004521 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1127744004522 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1127744004523 dimer interface [polypeptide binding]; other site 1127744004524 putative functional site; other site 1127744004525 putative MPT binding site; other site 1127744004526 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1127744004527 Walker A motif; other site 1127744004528 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1127744004529 MoaE homodimer interface [polypeptide binding]; other site 1127744004530 MoaD interaction [polypeptide binding]; other site 1127744004531 active site residues [active] 1127744004532 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1127744004533 MoaE interaction surface [polypeptide binding]; other site 1127744004534 MoeB interaction surface [polypeptide binding]; other site 1127744004535 thiocarboxylated glycine; other site 1127744004536 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127744004537 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1127744004538 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1127744004539 Walker A/P-loop; other site 1127744004540 ATP binding site [chemical binding]; other site 1127744004541 Q-loop/lid; other site 1127744004542 ABC transporter signature motif; other site 1127744004543 Walker B; other site 1127744004544 D-loop; other site 1127744004545 H-loop/switch region; other site 1127744004546 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127744004547 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1127744004548 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1127744004549 Walker A/P-loop; other site 1127744004550 ATP binding site [chemical binding]; other site 1127744004551 Q-loop/lid; other site 1127744004552 ABC transporter signature motif; other site 1127744004553 Walker B; other site 1127744004554 D-loop; other site 1127744004555 H-loop/switch region; other site 1127744004556 Yip1 domain; Region: Yip1; pfam04893 1127744004557 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1127744004558 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1127744004559 HlyD family secretion protein; Region: HlyD_3; pfam13437 1127744004560 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1127744004561 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1127744004562 Walker A/P-loop; other site 1127744004563 ATP binding site [chemical binding]; other site 1127744004564 Q-loop/lid; other site 1127744004565 ABC transporter signature motif; other site 1127744004566 Walker B; other site 1127744004567 D-loop; other site 1127744004568 H-loop/switch region; other site 1127744004569 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1127744004570 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1127744004571 FtsX-like permease family; Region: FtsX; pfam02687 1127744004572 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1127744004573 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1127744004574 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1127744004575 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1127744004576 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1127744004577 putative substrate binding site [chemical binding]; other site 1127744004578 putative ATP binding site [chemical binding]; other site 1127744004579 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1127744004580 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1127744004581 active site 1127744004582 phosphorylation site [posttranslational modification] 1127744004583 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1127744004584 active site 1127744004585 P-loop; other site 1127744004586 phosphorylation site [posttranslational modification] 1127744004587 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1127744004588 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1127744004589 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1127744004590 Catalytic site [active] 1127744004591 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1127744004592 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1127744004593 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1127744004594 ABC transporter; Region: ABC_tran_2; pfam12848 1127744004595 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1127744004596 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1127744004597 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1127744004598 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1127744004599 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1127744004600 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1127744004601 rod-share determining protein MreBH; Provisional; Region: PRK13929 1127744004602 MreB and similar proteins; Region: MreB_like; cd10225 1127744004603 nucleotide binding site [chemical binding]; other site 1127744004604 Mg binding site [ion binding]; other site 1127744004605 putative protofilament interaction site [polypeptide binding]; other site 1127744004606 RodZ interaction site [polypeptide binding]; other site 1127744004607 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1127744004608 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1127744004609 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1127744004610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1127744004611 putative active site [active] 1127744004612 heme pocket [chemical binding]; other site 1127744004613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744004614 dimer interface [polypeptide binding]; other site 1127744004615 phosphorylation site [posttranslational modification] 1127744004616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744004617 ATP binding site [chemical binding]; other site 1127744004618 Mg2+ binding site [ion binding]; other site 1127744004619 G-X-G motif; other site 1127744004620 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1127744004621 putative active site pocket [active] 1127744004622 dimerization interface [polypeptide binding]; other site 1127744004623 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1127744004624 putative active site pocket [active] 1127744004625 dimerization interface [polypeptide binding]; other site 1127744004626 putative catalytic residue [active] 1127744004627 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1127744004628 TrkA-N domain; Region: TrkA_N; pfam02254 1127744004629 TrkA-C domain; Region: TrkA_C; pfam02080 1127744004630 adenine deaminase; Region: ade; TIGR01178 1127744004631 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127744004632 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1127744004633 active site 1127744004634 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1127744004635 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1127744004636 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1127744004637 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1127744004638 hypothetical protein; Provisional; Region: PRK13667 1127744004639 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1127744004640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744004641 active site 1127744004642 motif I; other site 1127744004643 motif II; other site 1127744004644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744004645 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1127744004646 active site 1127744004647 catalytic residues [active] 1127744004648 metal binding site [ion binding]; metal-binding site 1127744004649 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1127744004650 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1127744004651 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1127744004652 TPP-binding site [chemical binding]; other site 1127744004653 tetramer interface [polypeptide binding]; other site 1127744004654 heterodimer interface [polypeptide binding]; other site 1127744004655 phosphorylation loop region [posttranslational modification] 1127744004656 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1127744004657 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1127744004658 alpha subunit interface [polypeptide binding]; other site 1127744004659 TPP binding site [chemical binding]; other site 1127744004660 heterodimer interface [polypeptide binding]; other site 1127744004661 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1127744004662 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1127744004663 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1127744004664 E3 interaction surface; other site 1127744004665 lipoyl attachment site [posttranslational modification]; other site 1127744004666 e3 binding domain; Region: E3_binding; pfam02817 1127744004667 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1127744004668 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1127744004669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1127744004670 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127744004671 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1127744004672 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1127744004673 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1127744004674 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1127744004675 homodimer interface [polypeptide binding]; other site 1127744004676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744004677 catalytic residue [active] 1127744004678 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1127744004679 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1127744004680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1127744004681 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1127744004682 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1127744004683 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1127744004684 active site 1127744004685 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1127744004686 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1127744004687 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1127744004688 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1127744004689 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1127744004690 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1127744004691 active site 1127744004692 Zn binding site [ion binding]; other site 1127744004693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744004694 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 1127744004695 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744004696 DNA binding residues [nucleotide binding] 1127744004697 Putative zinc-finger; Region: zf-HC2; pfam13490 1127744004698 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1127744004699 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1127744004700 G1 box; other site 1127744004701 putative GEF interaction site [polypeptide binding]; other site 1127744004702 GTP/Mg2+ binding site [chemical binding]; other site 1127744004703 Switch I region; other site 1127744004704 G2 box; other site 1127744004705 G3 box; other site 1127744004706 Switch II region; other site 1127744004707 G4 box; other site 1127744004708 G5 box; other site 1127744004709 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1127744004710 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1127744004711 YlaH-like protein; Region: YlaH; pfam14036 1127744004712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 1127744004713 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1127744004714 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1127744004715 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1127744004716 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1127744004717 putative active site [active] 1127744004718 PhoH-like protein; Region: PhoH; pfam02562 1127744004719 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1127744004720 glutaminase A; Region: Gln_ase; TIGR03814 1127744004721 hypothetical protein; Provisional; Region: PRK13666 1127744004722 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1127744004723 pyruvate carboxylase; Reviewed; Region: PRK12999 1127744004724 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127744004725 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1127744004726 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1127744004727 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1127744004728 active site 1127744004729 catalytic residues [active] 1127744004730 metal binding site [ion binding]; metal-binding site 1127744004731 homodimer binding site [polypeptide binding]; other site 1127744004732 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1127744004733 carboxyltransferase (CT) interaction site; other site 1127744004734 biotinylation site [posttranslational modification]; other site 1127744004735 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1127744004736 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1127744004737 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1127744004738 UbiA prenyltransferase family; Region: UbiA; pfam01040 1127744004739 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1127744004740 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1127744004741 Cytochrome c; Region: Cytochrom_C; pfam00034 1127744004742 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1127744004743 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1127744004744 D-pathway; other site 1127744004745 Putative ubiquinol binding site [chemical binding]; other site 1127744004746 Low-spin heme (heme b) binding site [chemical binding]; other site 1127744004747 Putative water exit pathway; other site 1127744004748 Binuclear center (heme o3/CuB) [ion binding]; other site 1127744004749 K-pathway; other site 1127744004750 Putative proton exit pathway; other site 1127744004751 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1127744004752 Subunit I/III interface [polypeptide binding]; other site 1127744004753 Subunit III/IV interface [polypeptide binding]; other site 1127744004754 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 1127744004755 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 1127744004756 YugN-like family; Region: YugN; pfam08868 1127744004757 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1127744004758 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1127744004759 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1127744004760 Putative coat protein; Region: YlbD_coat; pfam14071 1127744004761 YlbE-like protein; Region: YlbE; pfam14003 1127744004762 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1127744004763 hypothetical protein; Provisional; Region: PRK02886 1127744004764 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1127744004765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744004766 S-adenosylmethionine binding site [chemical binding]; other site 1127744004767 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1127744004768 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1127744004769 active site 1127744004770 (T/H)XGH motif; other site 1127744004771 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1127744004772 Nucleoside recognition; Region: Gate; pfam07670 1127744004773 Nucleoside recognition; Region: Gate; pfam07670 1127744004774 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1127744004775 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1127744004776 nucleophile elbow; other site 1127744004777 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1127744004778 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1127744004779 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1127744004780 protein binding site [polypeptide binding]; other site 1127744004781 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1127744004782 hypothetical protein; Provisional; Region: PRK13670 1127744004783 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1127744004784 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1127744004785 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1127744004786 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1127744004787 hypothetical protein; Provisional; Region: PRK13688 1127744004788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744004789 Coenzyme A binding pocket [chemical binding]; other site 1127744004790 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1127744004791 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1127744004792 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1127744004793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1127744004794 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1127744004795 mraZ protein; Region: TIGR00242 1127744004796 MraZ protein; Region: MraZ; pfam02381 1127744004797 MraZ protein; Region: MraZ; pfam02381 1127744004798 MraW methylase family; Region: Methyltransf_5; pfam01795 1127744004799 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1127744004800 Cell division protein FtsL; Region: FtsL; cl11433 1127744004801 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1127744004802 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1127744004803 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1127744004804 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1127744004805 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1127744004806 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1127744004807 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1127744004808 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1127744004809 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1127744004810 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1127744004811 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1127744004812 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1127744004813 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1127744004814 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1127744004815 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1127744004816 Mg++ binding site [ion binding]; other site 1127744004817 putative catalytic motif [active] 1127744004818 putative substrate binding site [chemical binding]; other site 1127744004819 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1127744004820 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1127744004821 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1127744004822 stage V sporulation protein E; Region: spoVE; TIGR02615 1127744004823 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1127744004824 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1127744004825 active site 1127744004826 homodimer interface [polypeptide binding]; other site 1127744004827 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1127744004828 FAD binding domain; Region: FAD_binding_4; pfam01565 1127744004829 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1127744004830 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1127744004831 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1127744004832 Cell division protein FtsQ; Region: FtsQ; pfam03799 1127744004833 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1127744004834 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1127744004835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1127744004836 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1127744004837 Uncharacterized conserved protein (small basic protein) [Function unknown]; Region: Sbp; COG3856 1127744004838 cell division protein FtsA; Region: ftsA; TIGR01174 1127744004839 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1127744004840 nucleotide binding site [chemical binding]; other site 1127744004841 Cell division protein FtsA; Region: FtsA; pfam14450 1127744004842 cell division protein FtsZ; Validated; Region: PRK09330 1127744004843 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1127744004844 nucleotide binding site [chemical binding]; other site 1127744004845 SulA interaction site; other site 1127744004846 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1127744004847 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1127744004848 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1127744004849 active site 1127744004850 catalytic triad [active] 1127744004851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1127744004852 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1127744004853 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1127744004854 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1127744004855 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1127744004856 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1127744004857 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1127744004858 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744004859 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744004860 DNA binding residues [nucleotide binding] 1127744004861 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1127744004862 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744004863 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1127744004864 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744004865 DNA binding residues [nucleotide binding] 1127744004866 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1127744004867 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1127744004868 Walker A/P-loop; other site 1127744004869 ATP binding site [chemical binding]; other site 1127744004870 Q-loop/lid; other site 1127744004871 ABC transporter signature motif; other site 1127744004872 Walker B; other site 1127744004873 D-loop; other site 1127744004874 H-loop/switch region; other site 1127744004875 acetylornithine deacetylase; Validated; Region: PRK08596 1127744004876 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1127744004877 metal binding site [ion binding]; metal-binding site 1127744004878 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1127744004879 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1127744004880 uncharacterized protein, YfiH family; Region: TIGR00726 1127744004881 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1127744004882 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1127744004883 catalytic residue [active] 1127744004884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1127744004885 YGGT family; Region: YGGT; pfam02325 1127744004886 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1127744004887 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127744004888 RNA binding surface [nucleotide binding]; other site 1127744004889 DivIVA protein; Region: DivIVA; pfam05103 1127744004890 DivIVA domain; Region: DivI1A_domain; TIGR03544 1127744004891 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1127744004892 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1127744004893 HIGH motif; other site 1127744004894 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1127744004895 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1127744004896 active site 1127744004897 KMSKS motif; other site 1127744004898 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1127744004899 tRNA binding surface [nucleotide binding]; other site 1127744004900 anticodon binding site; other site 1127744004901 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1127744004902 lipoprotein signal peptidase; Region: lspA; TIGR00077 1127744004903 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1127744004904 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127744004905 RNA binding surface [nucleotide binding]; other site 1127744004906 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1127744004907 active site 1127744004908 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1127744004909 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127744004910 active site 1127744004911 uracil-xanthine permease; Region: ncs2; TIGR00801 1127744004912 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1127744004913 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1127744004914 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1127744004915 dihydroorotase; Validated; Region: pyrC; PRK09357 1127744004916 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1127744004917 active site 1127744004918 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1127744004919 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1127744004920 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1127744004921 catalytic site [active] 1127744004922 subunit interface [polypeptide binding]; other site 1127744004923 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1127744004924 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127744004925 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1127744004926 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1127744004927 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127744004928 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1127744004929 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1127744004930 IMP binding site; other site 1127744004931 dimer interface [polypeptide binding]; other site 1127744004932 interdomain contacts; other site 1127744004933 partial ornithine binding site; other site 1127744004934 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1127744004935 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1127744004936 FAD binding pocket [chemical binding]; other site 1127744004937 FAD binding motif [chemical binding]; other site 1127744004938 phosphate binding motif [ion binding]; other site 1127744004939 beta-alpha-beta structure motif; other site 1127744004940 NAD binding pocket [chemical binding]; other site 1127744004941 Iron coordination center [ion binding]; other site 1127744004942 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1127744004943 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1127744004944 heterodimer interface [polypeptide binding]; other site 1127744004945 active site 1127744004946 FMN binding site [chemical binding]; other site 1127744004947 homodimer interface [polypeptide binding]; other site 1127744004948 substrate binding site [chemical binding]; other site 1127744004949 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1127744004950 active site 1127744004951 dimer interface [polypeptide binding]; other site 1127744004952 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127744004953 active site 1127744004954 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1127744004955 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1127744004956 Active Sites [active] 1127744004957 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1127744004958 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1127744004959 ATP-sulfurylase; Region: ATPS; cd00517 1127744004960 active site 1127744004961 HXXH motif; other site 1127744004962 flexible loop; other site 1127744004963 AAA domain; Region: AAA_33; pfam13671 1127744004964 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1127744004965 ligand-binding site [chemical binding]; other site 1127744004966 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1127744004967 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1127744004968 active site 1127744004969 SAM binding site [chemical binding]; other site 1127744004970 homodimer interface [polypeptide binding]; other site 1127744004971 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1127744004972 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1127744004973 putative active site [active] 1127744004974 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1127744004975 putative active site [active] 1127744004976 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1127744004977 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1127744004978 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1127744004979 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1127744004980 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1127744004981 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1127744004982 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1127744004983 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1127744004984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744004985 motif II; other site 1127744004986 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1127744004987 TIGR00255 family protein; Region: TIGR00255 1127744004988 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1127744004989 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1127744004990 hypothetical protein; Provisional; Region: PRK04323 1127744004991 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1127744004992 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1127744004993 catalytic site [active] 1127744004994 G-X2-G-X-G-K; other site 1127744004995 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1127744004996 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1127744004997 Flavoprotein; Region: Flavoprotein; pfam02441 1127744004998 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1127744004999 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1127744005000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127744005001 ATP binding site [chemical binding]; other site 1127744005002 putative Mg++ binding site [ion binding]; other site 1127744005003 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127744005004 nucleotide binding region [chemical binding]; other site 1127744005005 ATP-binding site [chemical binding]; other site 1127744005006 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1127744005007 active site 1127744005008 catalytic residues [active] 1127744005009 metal binding site [ion binding]; metal-binding site 1127744005010 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1127744005011 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1127744005012 putative active site [active] 1127744005013 substrate binding site [chemical binding]; other site 1127744005014 putative cosubstrate binding site; other site 1127744005015 catalytic site [active] 1127744005016 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1127744005017 substrate binding site [chemical binding]; other site 1127744005018 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1127744005019 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1127744005020 putative RNA binding site [nucleotide binding]; other site 1127744005021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744005022 S-adenosylmethionine binding site [chemical binding]; other site 1127744005023 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1127744005024 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127744005025 FeS/SAM binding site; other site 1127744005026 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1127744005027 Protein phosphatase 2C; Region: PP2C; pfam00481 1127744005028 active site 1127744005029 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1127744005030 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1127744005031 active site 1127744005032 ATP binding site [chemical binding]; other site 1127744005033 substrate binding site [chemical binding]; other site 1127744005034 activation loop (A-loop); other site 1127744005035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1127744005036 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1127744005037 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1127744005038 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1127744005039 GTPase RsgA; Reviewed; Region: PRK00098 1127744005040 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1127744005041 RNA binding site [nucleotide binding]; other site 1127744005042 homodimer interface [polypeptide binding]; other site 1127744005043 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1127744005044 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1127744005045 GTP/Mg2+ binding site [chemical binding]; other site 1127744005046 G4 box; other site 1127744005047 G5 box; other site 1127744005048 G1 box; other site 1127744005049 Switch I region; other site 1127744005050 G2 box; other site 1127744005051 G3 box; other site 1127744005052 Switch II region; other site 1127744005053 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1127744005054 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1127744005055 substrate binding site [chemical binding]; other site 1127744005056 hexamer interface [polypeptide binding]; other site 1127744005057 metal binding site [ion binding]; metal-binding site 1127744005058 Thiamine pyrophosphokinase; Region: TPK; cd07995 1127744005059 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1127744005060 active site 1127744005061 dimerization interface [polypeptide binding]; other site 1127744005062 thiamine binding site [chemical binding]; other site 1127744005063 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 1127744005064 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1127744005065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1127744005066 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1127744005067 DAK2 domain; Region: Dak2; pfam02734 1127744005068 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1127744005069 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1127744005070 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1127744005071 putative L-serine binding site [chemical binding]; other site 1127744005072 L-serine dehydratase, iron-sulfur-dependent, alpha subunit; Region: sda_alpha; TIGR00718 1127744005073 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1127744005074 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1127744005075 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1127744005076 generic binding surface II; other site 1127744005077 ssDNA binding site; other site 1127744005078 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127744005079 ATP binding site [chemical binding]; other site 1127744005080 putative Mg++ binding site [ion binding]; other site 1127744005081 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127744005082 nucleotide binding region [chemical binding]; other site 1127744005083 ATP-binding site [chemical binding]; other site 1127744005084 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1127744005085 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1127744005086 putative phosphate acyltransferase; Provisional; Region: PRK05331 1127744005087 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1127744005088 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1127744005089 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1127744005090 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1127744005091 NAD(P) binding site [chemical binding]; other site 1127744005092 homotetramer interface [polypeptide binding]; other site 1127744005093 homodimer interface [polypeptide binding]; other site 1127744005094 active site 1127744005095 acyl carrier protein; Provisional; Region: acpP; PRK00982 1127744005096 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1127744005097 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1127744005098 dimerization interface [polypeptide binding]; other site 1127744005099 active site 1127744005100 metal binding site [ion binding]; metal-binding site 1127744005101 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1127744005102 dsRNA binding site [nucleotide binding]; other site 1127744005103 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1127744005104 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1127744005105 Walker A/P-loop; other site 1127744005106 ATP binding site [chemical binding]; other site 1127744005107 Q-loop/lid; other site 1127744005108 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1127744005109 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1127744005110 ABC transporter signature motif; other site 1127744005111 Walker B; other site 1127744005112 D-loop; other site 1127744005113 H-loop/switch region; other site 1127744005114 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1127744005115 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1127744005116 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1127744005117 GTP binding site [chemical binding]; other site 1127744005118 Phosphotransferase enzyme family; Region: APH; pfam01636 1127744005119 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1127744005120 active site 1127744005121 ATP binding site [chemical binding]; other site 1127744005122 substrate binding site [chemical binding]; other site 1127744005123 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1127744005124 putative DNA-binding protein; Validated; Region: PRK00118 1127744005125 signal recognition particle protein; Provisional; Region: PRK10867 1127744005126 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1127744005127 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1127744005128 P loop; other site 1127744005129 GTP binding site [chemical binding]; other site 1127744005130 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1127744005131 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1127744005132 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1127744005133 KH domain; Region: KH_4; pfam13083 1127744005134 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1127744005135 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1127744005136 RimM N-terminal domain; Region: RimM; pfam01782 1127744005137 PRC-barrel domain; Region: PRC; pfam05239 1127744005138 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1127744005139 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1127744005140 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1127744005141 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1127744005142 GTP/Mg2+ binding site [chemical binding]; other site 1127744005143 G4 box; other site 1127744005144 G5 box; other site 1127744005145 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1127744005146 G1 box; other site 1127744005147 G1 box; other site 1127744005148 GTP/Mg2+ binding site [chemical binding]; other site 1127744005149 Switch I region; other site 1127744005150 G2 box; other site 1127744005151 G2 box; other site 1127744005152 G3 box; other site 1127744005153 G3 box; other site 1127744005154 Switch II region; other site 1127744005155 Switch II region; other site 1127744005156 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1127744005157 RNA/DNA hybrid binding site [nucleotide binding]; other site 1127744005158 active site 1127744005159 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1127744005160 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1127744005161 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1127744005162 CoA-ligase; Region: Ligase_CoA; pfam00549 1127744005163 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1127744005164 CoA binding domain; Region: CoA_binding; smart00881 1127744005165 CoA-ligase; Region: Ligase_CoA; pfam00549 1127744005166 DNA protecting protein DprA; Region: dprA; TIGR00732 1127744005167 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1127744005168 DNA topoisomerase I; Validated; Region: PRK05582 1127744005169 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1127744005170 active site 1127744005171 interdomain interaction site; other site 1127744005172 putative metal-binding site [ion binding]; other site 1127744005173 nucleotide binding site [chemical binding]; other site 1127744005174 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1127744005175 domain I; other site 1127744005176 DNA binding groove [nucleotide binding] 1127744005177 phosphate binding site [ion binding]; other site 1127744005178 domain II; other site 1127744005179 domain III; other site 1127744005180 nucleotide binding site [chemical binding]; other site 1127744005181 catalytic site [active] 1127744005182 domain IV; other site 1127744005183 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1127744005184 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1127744005185 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1127744005186 Glucose inhibited division protein A; Region: GIDA; pfam01134 1127744005187 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1127744005188 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1127744005189 active site 1127744005190 Int/Topo IB signature motif; other site 1127744005191 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1127744005192 active site 1127744005193 HslU subunit interaction site [polypeptide binding]; other site 1127744005194 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1127744005195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744005196 Walker A motif; other site 1127744005197 ATP binding site [chemical binding]; other site 1127744005198 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1127744005199 Walker B motif; other site 1127744005200 arginine finger; other site 1127744005201 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1127744005202 transcriptional repressor CodY; Validated; Region: PRK04158 1127744005203 CodY GAF-like domain; Region: CodY; pfam06018 1127744005204 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1127744005205 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1127744005206 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1127744005207 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1127744005208 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1127744005209 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1127744005210 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1127744005211 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 1127744005212 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1127744005213 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1127744005214 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1127744005215 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1127744005216 MgtE intracellular N domain; Region: MgtE_N; smart00924 1127744005217 FliG C-terminal domain; Region: FliG_C; pfam01706 1127744005218 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 1127744005219 Flagellar assembly protein FliH; Region: FliH; pfam02108 1127744005220 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1127744005221 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1127744005222 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1127744005223 Walker A motif/ATP binding site; other site 1127744005224 Walker B motif; other site 1127744005225 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1127744005226 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1127744005227 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1127744005228 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1127744005229 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1127744005230 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1127744005231 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1127744005232 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1127744005233 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1127744005234 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1127744005235 Uncharacterized protein, possibly involved in motility [Cell motility and secretion]; Region: FlgEa; COG1582 1127744005236 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1127744005237 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 1127744005238 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1127744005239 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1127744005240 flagellar motor switch protein; Validated; Region: PRK08119 1127744005241 CheC-like family; Region: CheC; pfam04509 1127744005242 CheC-like family; Region: CheC; pfam04509 1127744005243 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1127744005244 Response regulator receiver domain; Region: Response_reg; pfam00072 1127744005245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744005246 active site 1127744005247 phosphorylation site [posttranslational modification] 1127744005248 intermolecular recognition site; other site 1127744005249 dimerization interface [polypeptide binding]; other site 1127744005250 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 1127744005251 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1127744005252 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1127744005253 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1127744005254 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1127744005255 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1127744005256 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1127744005257 FHIPEP family; Region: FHIPEP; pfam00771 1127744005258 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1127744005259 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1127744005260 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1127744005261 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1127744005262 P-loop; other site 1127744005263 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1127744005264 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1127744005265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744005266 active site 1127744005267 phosphorylation site [posttranslational modification] 1127744005268 intermolecular recognition site; other site 1127744005269 dimerization interface [polypeptide binding]; other site 1127744005270 CheB methylesterase; Region: CheB_methylest; pfam01339 1127744005271 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1127744005272 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1127744005273 putative binding surface; other site 1127744005274 active site 1127744005275 P2 response regulator binding domain; Region: P2; pfam07194 1127744005276 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1127744005277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744005278 ATP binding site [chemical binding]; other site 1127744005279 Mg2+ binding site [ion binding]; other site 1127744005280 G-X-G motif; other site 1127744005281 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1127744005282 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1127744005283 putative CheA interaction surface; other site 1127744005284 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1127744005285 CheC-like family; Region: CheC; pfam04509 1127744005286 CheC-like family; Region: CheC; pfam04509 1127744005287 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1127744005288 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1127744005289 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744005290 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1127744005291 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744005292 DNA binding residues [nucleotide binding] 1127744005293 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1127744005294 rRNA interaction site [nucleotide binding]; other site 1127744005295 S8 interaction site; other site 1127744005296 putative laminin-1 binding site; other site 1127744005297 elongation factor Ts; Provisional; Region: tsf; PRK09377 1127744005298 UBA/TS-N domain; Region: UBA; pfam00627 1127744005299 Elongation factor TS; Region: EF_TS; pfam00889 1127744005300 Elongation factor TS; Region: EF_TS; pfam00889 1127744005301 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1127744005302 putative nucleotide binding site [chemical binding]; other site 1127744005303 uridine monophosphate binding site [chemical binding]; other site 1127744005304 homohexameric interface [polypeptide binding]; other site 1127744005305 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1127744005306 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1127744005307 hinge region; other site 1127744005308 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1127744005309 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1127744005310 catalytic residue [active] 1127744005311 putative FPP diphosphate binding site; other site 1127744005312 putative FPP binding hydrophobic cleft; other site 1127744005313 dimer interface [polypeptide binding]; other site 1127744005314 putative IPP diphosphate binding site; other site 1127744005315 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1127744005316 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1127744005317 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1127744005318 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1127744005319 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1127744005320 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1127744005321 RIP metalloprotease RseP; Region: TIGR00054 1127744005322 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1127744005323 active site 1127744005324 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1127744005325 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1127744005326 protein binding site [polypeptide binding]; other site 1127744005327 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1127744005328 putative substrate binding region [chemical binding]; other site 1127744005329 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1127744005330 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1127744005331 dimer interface [polypeptide binding]; other site 1127744005332 motif 1; other site 1127744005333 active site 1127744005334 motif 2; other site 1127744005335 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1127744005336 putative deacylase active site [active] 1127744005337 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1127744005338 active site 1127744005339 motif 3; other site 1127744005340 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1127744005341 anticodon binding site; other site 1127744005342 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1127744005343 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1127744005344 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1127744005345 generic binding surface II; other site 1127744005346 generic binding surface I; other site 1127744005347 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1127744005348 active site 1127744005349 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1127744005350 active site 1127744005351 catalytic site [active] 1127744005352 substrate binding site [chemical binding]; other site 1127744005353 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1127744005354 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1127744005355 Sm and related proteins; Region: Sm_like; cl00259 1127744005356 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1127744005357 putative oligomer interface [polypeptide binding]; other site 1127744005358 putative RNA binding site [nucleotide binding]; other site 1127744005359 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1127744005360 NusA N-terminal domain; Region: NusA_N; pfam08529 1127744005361 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1127744005362 RNA binding site [nucleotide binding]; other site 1127744005363 homodimer interface [polypeptide binding]; other site 1127744005364 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1127744005365 G-X-X-G motif; other site 1127744005366 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1127744005367 G-X-X-G motif; other site 1127744005368 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1127744005369 putative RNA binding cleft [nucleotide binding]; other site 1127744005370 hypothetical protein; Provisional; Region: PRK07714 1127744005371 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1127744005372 translation initiation factor IF-2; Region: IF-2; TIGR00487 1127744005373 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1127744005374 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1127744005375 G1 box; other site 1127744005376 putative GEF interaction site [polypeptide binding]; other site 1127744005377 GTP/Mg2+ binding site [chemical binding]; other site 1127744005378 Switch I region; other site 1127744005379 G2 box; other site 1127744005380 G3 box; other site 1127744005381 Switch II region; other site 1127744005382 G4 box; other site 1127744005383 G5 box; other site 1127744005384 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1127744005385 Translation-initiation factor 2; Region: IF-2; pfam11987 1127744005386 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1127744005387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1127744005388 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1127744005389 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1127744005390 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1127744005391 RNA binding site [nucleotide binding]; other site 1127744005392 active site 1127744005393 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1127744005394 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 1127744005395 active site 1127744005396 Riboflavin kinase; Region: Flavokinase; smart00904 1127744005397 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1127744005398 16S/18S rRNA binding site [nucleotide binding]; other site 1127744005399 S13e-L30e interaction site [polypeptide binding]; other site 1127744005400 25S rRNA binding site [nucleotide binding]; other site 1127744005401 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1127744005402 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1127744005403 RNase E interface [polypeptide binding]; other site 1127744005404 trimer interface [polypeptide binding]; other site 1127744005405 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1127744005406 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1127744005407 RNase E interface [polypeptide binding]; other site 1127744005408 trimer interface [polypeptide binding]; other site 1127744005409 active site 1127744005410 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1127744005411 putative nucleic acid binding region [nucleotide binding]; other site 1127744005412 G-X-X-G motif; other site 1127744005413 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1127744005414 RNA binding site [nucleotide binding]; other site 1127744005415 domain interface; other site 1127744005416 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1127744005417 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1127744005418 NodB motif; other site 1127744005419 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1127744005420 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1127744005421 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1127744005422 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1127744005423 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1127744005424 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1127744005425 NAD binding site [chemical binding]; other site 1127744005426 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 1127744005427 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1127744005428 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1127744005429 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1127744005430 aspartate kinase I; Reviewed; Region: PRK08210 1127744005431 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1127744005432 putative catalytic residues [active] 1127744005433 putative nucleotide binding site [chemical binding]; other site 1127744005434 putative aspartate binding site [chemical binding]; other site 1127744005435 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1127744005436 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1127744005437 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1127744005438 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1127744005439 dimer interface [polypeptide binding]; other site 1127744005440 active site 1127744005441 catalytic residue [active] 1127744005442 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1127744005443 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1127744005444 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1127744005445 Clp protease; Region: CLP_protease; pfam00574 1127744005446 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1127744005447 active site 1127744005448 YlzJ-like protein; Region: YlzJ; pfam14035 1127744005449 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1127744005450 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1127744005451 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1127744005452 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1127744005453 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1127744005454 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744005455 DNA-binding site [nucleotide binding]; DNA binding site 1127744005456 UTRA domain; Region: UTRA; pfam07702 1127744005457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744005458 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744005459 putative substrate translocation pore; other site 1127744005460 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1127744005461 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1127744005462 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1127744005463 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1127744005464 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1127744005465 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1127744005466 classical (c) SDRs; Region: SDR_c; cd05233 1127744005467 NAD(P) binding site [chemical binding]; other site 1127744005468 active site 1127744005469 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1127744005470 ACT domain; Region: ACT; pfam01842 1127744005471 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1127744005472 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1127744005473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127744005474 non-specific DNA binding site [nucleotide binding]; other site 1127744005475 salt bridge; other site 1127744005476 sequence-specific DNA binding site [nucleotide binding]; other site 1127744005477 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1127744005478 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1127744005479 competence damage-inducible protein A; Provisional; Region: PRK00549 1127744005480 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1127744005481 putative MPT binding site; other site 1127744005482 competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199 1127744005483 recombinase A; Provisional; Region: recA; PRK09354 1127744005484 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1127744005485 hexamer interface [polypeptide binding]; other site 1127744005486 Walker A motif; other site 1127744005487 ATP binding site [chemical binding]; other site 1127744005488 Walker B motif; other site 1127744005489 Beta-lactamase; Region: Beta-lactamase; pfam00144 1127744005490 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1127744005491 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1127744005492 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1127744005493 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1127744005494 Zn2+ binding site [ion binding]; other site 1127744005495 Mg2+ binding site [ion binding]; other site 1127744005496 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1127744005497 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1127744005498 putative active site [active] 1127744005499 metal binding site [ion binding]; metal-binding site 1127744005500 homodimer binding site [polypeptide binding]; other site 1127744005501 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1127744005502 Threonine dehydrogenase; Region: TDH; cd05281 1127744005503 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 1127744005504 structural Zn binding site [ion binding]; other site 1127744005505 catalytic Zn binding site [ion binding]; other site 1127744005506 tetramer interface [polypeptide binding]; other site 1127744005507 NADP binding site [chemical binding]; other site 1127744005508 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1127744005509 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1127744005510 substrate-cofactor binding pocket; other site 1127744005511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744005512 catalytic residue [active] 1127744005513 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1127744005514 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1127744005515 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127744005516 FeS/SAM binding site; other site 1127744005517 TRAM domain; Region: TRAM; pfam01938 1127744005518 Predicted membrane protein [Function unknown]; Region: COG4550 1127744005519 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1127744005520 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1127744005521 MutS domain I; Region: MutS_I; pfam01624 1127744005522 MutS domain II; Region: MutS_II; pfam05188 1127744005523 MutS domain III; Region: MutS_III; pfam05192 1127744005524 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1127744005525 Walker A/P-loop; other site 1127744005526 ATP binding site [chemical binding]; other site 1127744005527 Q-loop/lid; other site 1127744005528 ABC transporter signature motif; other site 1127744005529 Walker B; other site 1127744005530 D-loop; other site 1127744005531 H-loop/switch region; other site 1127744005532 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1127744005533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744005534 ATP binding site [chemical binding]; other site 1127744005535 Mg2+ binding site [ion binding]; other site 1127744005536 G-X-G motif; other site 1127744005537 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1127744005538 ATP binding site [chemical binding]; other site 1127744005539 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1127744005540 Regulatory protein YrvL; Region: YrvL; pfam14184 1127744005541 transcriptional regulator BetI; Validated; Region: PRK00767 1127744005542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744005543 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1127744005544 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1127744005545 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1127744005546 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1127744005547 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1127744005548 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1127744005549 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1127744005550 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1127744005551 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1127744005552 FMN binding site [chemical binding]; other site 1127744005553 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1127744005554 substrate binding site [chemical binding]; other site 1127744005555 putative catalytic residue [active] 1127744005556 acyl carrier protein; Validated; Region: PRK07117 1127744005557 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1127744005558 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1127744005559 dimer interface [polypeptide binding]; other site 1127744005560 active site 1127744005561 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1127744005562 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1127744005563 dimer interface [polypeptide binding]; other site 1127744005564 active site 1127744005565 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127744005566 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1127744005567 substrate binding site [chemical binding]; other site 1127744005568 oxyanion hole (OAH) forming residues; other site 1127744005569 trimer interface [polypeptide binding]; other site 1127744005570 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1127744005571 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127744005572 substrate binding site [chemical binding]; other site 1127744005573 oxyanion hole (OAH) forming residues; other site 1127744005574 trimer interface [polypeptide binding]; other site 1127744005575 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 1127744005576 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1127744005577 acyl-activating enzyme (AAE) consensus motif; other site 1127744005578 putative AMP binding site [chemical binding]; other site 1127744005579 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744005580 Condensation domain; Region: Condensation; pfam00668 1127744005581 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744005582 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744005583 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1127744005584 acyl-activating enzyme (AAE) consensus motif; other site 1127744005585 AMP binding site [chemical binding]; other site 1127744005586 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744005587 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1127744005588 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744005589 active site 1127744005590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127744005591 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1127744005592 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1127744005593 KR domain; Region: KR; pfam08659 1127744005594 putative NADP binding site [chemical binding]; other site 1127744005595 active site 1127744005596 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1127744005597 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1127744005598 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1127744005599 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744005600 active site 1127744005601 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1127744005602 putative NADP binding site [chemical binding]; other site 1127744005603 active site 1127744005604 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744005605 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744005606 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1127744005607 active site 1127744005608 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1127744005609 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744005610 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1127744005611 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744005612 active site 1127744005613 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1127744005614 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1127744005615 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1127744005616 putative NADP binding site [chemical binding]; other site 1127744005617 active site 1127744005618 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744005619 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1127744005620 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744005621 active site 1127744005622 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1127744005623 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1127744005624 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1127744005625 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744005626 active site 1127744005627 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1127744005628 putative NADP binding site [chemical binding]; other site 1127744005629 active site 1127744005630 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744005631 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744005632 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1127744005633 active site 1127744005634 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1127744005635 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1127744005636 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1127744005637 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744005638 active site 1127744005639 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1127744005640 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1127744005641 putative NADP binding site [chemical binding]; other site 1127744005642 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1127744005643 active site 1127744005644 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1127744005645 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1127744005646 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1127744005647 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744005648 active site 1127744005649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127744005650 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1127744005651 putative NADP binding site [chemical binding]; other site 1127744005652 active site 1127744005653 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744005654 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744005655 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1127744005656 active site 1127744005657 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744005658 Condensation domain; Region: Condensation; pfam00668 1127744005659 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744005660 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744005661 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744005662 acyl-activating enzyme (AAE) consensus motif; other site 1127744005663 AMP binding site [chemical binding]; other site 1127744005664 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744005665 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1127744005666 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744005667 active site 1127744005668 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1127744005669 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1127744005670 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1127744005671 putative NADP binding site [chemical binding]; other site 1127744005672 active site 1127744005673 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1127744005674 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1127744005675 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744005676 active site 1127744005677 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1127744005678 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1127744005679 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1127744005680 putative NADP binding site [chemical binding]; other site 1127744005681 active site 1127744005682 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1127744005683 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1127744005684 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744005685 active site 1127744005686 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1127744005687 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1127744005688 putative NADP binding site [chemical binding]; other site 1127744005689 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1127744005690 active site 1127744005691 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1127744005692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744005693 S-adenosylmethionine binding site [chemical binding]; other site 1127744005694 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1127744005695 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744005696 active site 1127744005697 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744005698 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1127744005699 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1127744005700 active site 1127744005701 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744005702 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1127744005703 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1127744005704 Cytochrome P450; Region: p450; cl12078 1127744005705 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1127744005706 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1127744005707 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1127744005708 active site 1127744005709 catalytic triad [active] 1127744005710 WYL domain; Region: WYL; cl14852 1127744005711 Phage-related replication protein [General function prediction only]; Region: COG4195 1127744005712 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1127744005713 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1127744005714 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1127744005715 YmaF family; Region: YmaF; pfam12788 1127744005716 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1127744005717 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1127744005718 bacterial Hfq-like; Region: Hfq; cd01716 1127744005719 hexamer interface [polypeptide binding]; other site 1127744005720 Sm1 motif; other site 1127744005721 RNA binding site [nucleotide binding]; other site 1127744005722 Sm2 motif; other site 1127744005723 YmzC-like protein; Region: YmzC; pfam14157 1127744005724 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1127744005725 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1127744005726 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1127744005727 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1127744005728 active site 1127744005729 dimer interface [polypeptide binding]; other site 1127744005730 catalytic residues [active] 1127744005731 effector binding site; other site 1127744005732 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1127744005733 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1127744005734 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1127744005735 dimer interface [polypeptide binding]; other site 1127744005736 putative radical transfer pathway; other site 1127744005737 diiron center [ion binding]; other site 1127744005738 tyrosyl radical; other site 1127744005739 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1127744005740 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1127744005741 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1127744005742 active site 1127744005743 metal binding site [ion binding]; metal-binding site 1127744005744 Sporulation related domain; Region: SPOR; pfam05036 1127744005745 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1127744005746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744005747 Walker A motif; other site 1127744005748 ATP binding site [chemical binding]; other site 1127744005749 Walker B motif; other site 1127744005750 arginine finger; other site 1127744005751 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1127744005752 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1127744005753 HflX GTPase family; Region: HflX; cd01878 1127744005754 G1 box; other site 1127744005755 GTP/Mg2+ binding site [chemical binding]; other site 1127744005756 Switch I region; other site 1127744005757 G2 box; other site 1127744005758 G3 box; other site 1127744005759 Switch II region; other site 1127744005760 G4 box; other site 1127744005761 G5 box; other site 1127744005762 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1127744005763 Aluminium resistance protein; Region: Alum_res; pfam06838 1127744005764 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1127744005765 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127744005766 DNA binding residues [nucleotide binding] 1127744005767 putative dimer interface [polypeptide binding]; other site 1127744005768 glutamine synthetase, type I; Region: GlnA; TIGR00653 1127744005769 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1127744005770 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1127744005771 LXG domain of WXG superfamily; Region: LXG; pfam04740 1127744005772 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1127744005773 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1127744005774 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1127744005775 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744005776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744005777 binding surface 1127744005778 TPR motif; other site 1127744005779 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1127744005780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744005781 Coenzyme A binding pocket [chemical binding]; other site 1127744005782 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1127744005783 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1127744005784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744005785 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1127744005786 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1127744005787 inhibitor binding site; inhibition site 1127744005788 active site 1127744005789 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1127744005790 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1127744005791 non-specific DNA interactions [nucleotide binding]; other site 1127744005792 DNA binding site [nucleotide binding] 1127744005793 sequence specific DNA binding site [nucleotide binding]; other site 1127744005794 putative cAMP binding site [chemical binding]; other site 1127744005795 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1127744005796 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1127744005797 nucleotide binding site [chemical binding]; other site 1127744005798 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1127744005799 xylose isomerase; Provisional; Region: PRK05474 1127744005800 xylose isomerase; Region: xylose_isom_A; TIGR02630 1127744005801 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1127744005802 N- and C-terminal domain interface [polypeptide binding]; other site 1127744005803 D-xylulose kinase; Region: XylB; TIGR01312 1127744005804 active site 1127744005805 MgATP binding site [chemical binding]; other site 1127744005806 catalytic site [active] 1127744005807 metal binding site [ion binding]; metal-binding site 1127744005808 xylulose binding site [chemical binding]; other site 1127744005809 homodimer interface [polypeptide binding]; other site 1127744005810 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1127744005811 Staphylococcal nuclease homologues; Region: SNc; smart00318 1127744005812 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1127744005813 Catalytic site; other site 1127744005814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744005815 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1127744005816 putative substrate translocation pore; other site 1127744005817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744005818 alanine racemase; Region: alr; TIGR00492 1127744005819 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1127744005820 active site 1127744005821 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1127744005822 dimer interface [polypeptide binding]; other site 1127744005823 substrate binding site [chemical binding]; other site 1127744005824 catalytic residues [active] 1127744005825 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1127744005826 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1127744005827 trimer interface [polypeptide binding]; other site 1127744005828 active site 1127744005829 VanZ like family; Region: VanZ; cl01971 1127744005830 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1127744005831 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1127744005832 dimerization interface [polypeptide binding]; other site 1127744005833 active site 1127744005834 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1127744005835 putative binding site; other site 1127744005836 putative dimer interface [polypeptide binding]; other site 1127744005837 YoqO-like protein; Region: YoqO; pfam14037 1127744005838 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1127744005839 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1127744005840 putative hydrophobic ligand binding site [chemical binding]; other site 1127744005841 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1127744005842 Spore germination protein; Region: Spore_permease; pfam03845 1127744005843 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1127744005844 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1127744005845 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1127744005846 YndJ-like protein; Region: YndJ; pfam14158 1127744005847 Phage-related replication protein [General function prediction only]; Region: COG4195 1127744005848 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1127744005849 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1127744005850 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 1127744005851 putative active site [active] 1127744005852 putative Mg binding site [ion binding]; other site 1127744005853 LexA repressor; Validated; Region: PRK00215 1127744005854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127744005855 putative DNA binding site [nucleotide binding]; other site 1127744005856 putative Zn2+ binding site [ion binding]; other site 1127744005857 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1127744005858 Catalytic site [active] 1127744005859 cell division suppressor protein YneA; Provisional; Region: PRK14125 1127744005860 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744005861 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1127744005862 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1127744005863 catalytic residues [active] 1127744005864 catalytic nucleophile [active] 1127744005865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 1127744005866 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1127744005867 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1127744005868 TPP-binding site [chemical binding]; other site 1127744005869 dimer interface [polypeptide binding]; other site 1127744005870 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1127744005871 PYR/PP interface [polypeptide binding]; other site 1127744005872 dimer interface [polypeptide binding]; other site 1127744005873 TPP binding site [chemical binding]; other site 1127744005874 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1127744005875 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1127744005876 hypothetical protein; Provisional; Region: PRK01844 1127744005877 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1127744005878 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1127744005879 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1127744005880 Response regulator receiver domain; Region: Response_reg; pfam00072 1127744005881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744005882 active site 1127744005883 phosphorylation site [posttranslational modification] 1127744005884 intermolecular recognition site; other site 1127744005885 dimerization interface [polypeptide binding]; other site 1127744005886 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 1127744005887 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1127744005888 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1127744005889 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1127744005890 putative dimer interface [polypeptide binding]; other site 1127744005891 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 1127744005892 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1127744005893 aconitate hydratase; Validated; Region: PRK09277 1127744005894 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1127744005895 substrate binding site [chemical binding]; other site 1127744005896 ligand binding site [chemical binding]; other site 1127744005897 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1127744005898 substrate binding site [chemical binding]; other site 1127744005899 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1127744005900 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1127744005901 catalytic residues [active] 1127744005902 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1127744005903 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1127744005904 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1127744005905 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1127744005906 active site 1127744005907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1127744005908 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1127744005909 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1127744005910 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1127744005911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744005912 ATP binding site [chemical binding]; other site 1127744005913 Mg2+ binding site [ion binding]; other site 1127744005914 G-X-G motif; other site 1127744005915 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1127744005916 anchoring element; other site 1127744005917 dimer interface [polypeptide binding]; other site 1127744005918 ATP binding site [chemical binding]; other site 1127744005919 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1127744005920 active site 1127744005921 putative metal-binding site [ion binding]; other site 1127744005922 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1127744005923 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1127744005924 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1127744005925 CAP-like domain; other site 1127744005926 active site 1127744005927 primary dimer interface [polypeptide binding]; other site 1127744005928 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127744005929 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127744005930 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127744005931 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1127744005932 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1127744005933 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1127744005934 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1127744005935 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1127744005936 Cellulose binding domain; Region: CBM_3; pfam00942 1127744005937 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1127744005938 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1127744005939 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1127744005940 substrate binding site [chemical binding]; other site 1127744005941 active site 1127744005942 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1127744005943 metal binding site [ion binding]; metal-binding site 1127744005944 ligand binding site [chemical binding]; other site 1127744005945 Predicted membrane protein [Function unknown]; Region: COG2246 1127744005946 GtrA-like protein; Region: GtrA; pfam04138 1127744005947 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1127744005948 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1127744005949 active site 1127744005950 tetramer interface; other site 1127744005951 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1127744005952 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1127744005953 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1127744005954 DHH family; Region: DHH; pfam01368 1127744005955 DHHA1 domain; Region: DHHA1; pfam02272 1127744005956 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1127744005957 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1127744005958 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1127744005959 enoyl-CoA hydratase; Provisional; Region: PRK07657 1127744005960 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127744005961 substrate binding site [chemical binding]; other site 1127744005962 oxyanion hole (OAH) forming residues; other site 1127744005963 trimer interface [polypeptide binding]; other site 1127744005964 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1127744005965 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1127744005966 active site 1127744005967 catalytic residues [active] 1127744005968 metal binding site [ion binding]; metal-binding site 1127744005969 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1127744005970 carboxyltransferase (CT) interaction site; other site 1127744005971 biotinylation site [posttranslational modification]; other site 1127744005972 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1127744005973 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127744005974 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1127744005975 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1127744005976 AMP-binding domain protein; Validated; Region: PRK08315 1127744005977 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1127744005978 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1127744005979 acyl-activating enzyme (AAE) consensus motif; other site 1127744005980 acyl-activating enzyme (AAE) consensus motif; other site 1127744005981 putative AMP binding site [chemical binding]; other site 1127744005982 putative active site [active] 1127744005983 putative CoA binding site [chemical binding]; other site 1127744005984 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127744005985 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127744005986 active site 1127744005987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1127744005988 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1127744005989 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1127744005990 Condensation domain; Region: Condensation; pfam00668 1127744005991 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744005992 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1127744005993 acyl-activating enzyme (AAE) consensus motif; other site 1127744005994 AMP binding site [chemical binding]; other site 1127744005995 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744005996 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1127744005997 Condensation domain; Region: Condensation; pfam00668 1127744005998 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744005999 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744006000 acyl-activating enzyme (AAE) consensus motif; other site 1127744006001 AMP binding site [chemical binding]; other site 1127744006002 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744006003 Condensation domain; Region: Condensation; pfam00668 1127744006004 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744006005 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744006006 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744006007 acyl-activating enzyme (AAE) consensus motif; other site 1127744006008 AMP binding site [chemical binding]; other site 1127744006009 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744006010 Condensation domain; Region: Condensation; pfam00668 1127744006011 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744006012 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744006013 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744006014 acyl-activating enzyme (AAE) consensus motif; other site 1127744006015 AMP binding site [chemical binding]; other site 1127744006016 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744006017 Condensation domain; Region: Condensation; pfam00668 1127744006018 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744006019 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1127744006020 Condensation domain; Region: Condensation; pfam00668 1127744006021 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744006022 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744006023 acyl-activating enzyme (AAE) consensus motif; other site 1127744006024 AMP binding site [chemical binding]; other site 1127744006025 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744006026 Condensation domain; Region: Condensation; pfam00668 1127744006027 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744006028 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744006029 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1127744006030 acyl-activating enzyme (AAE) consensus motif; other site 1127744006031 AMP binding site [chemical binding]; other site 1127744006032 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744006033 Condensation domain; Region: Condensation; pfam00668 1127744006034 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1127744006035 Condensation domain; Region: Condensation; pfam00668 1127744006036 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744006037 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744006038 acyl-activating enzyme (AAE) consensus motif; other site 1127744006039 AMP binding site [chemical binding]; other site 1127744006040 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744006041 Condensation domain; Region: Condensation; pfam00668 1127744006042 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744006043 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744006044 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744006045 acyl-activating enzyme (AAE) consensus motif; other site 1127744006046 AMP binding site [chemical binding]; other site 1127744006047 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744006048 Condensation domain; Region: Condensation; pfam00668 1127744006049 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744006050 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1127744006051 Condensation domain; Region: Condensation; pfam00668 1127744006052 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744006053 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744006054 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744006055 acyl-activating enzyme (AAE) consensus motif; other site 1127744006056 AMP binding site [chemical binding]; other site 1127744006057 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744006058 Condensation domain; Region: Condensation; pfam00668 1127744006059 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744006060 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744006061 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744006062 acyl-activating enzyme (AAE) consensus motif; other site 1127744006063 AMP binding site [chemical binding]; other site 1127744006064 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744006065 Condensation domain; Region: Condensation; pfam00668 1127744006066 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1127744006067 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1127744006068 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1127744006069 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1127744006070 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1127744006071 active site 1127744006072 catalytic residues [active] 1127744006073 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1127744006074 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1127744006075 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1127744006076 Int/Topo IB signature motif; other site 1127744006077 Helix-turn-helix domain; Region: HTH_17; cl17695 1127744006078 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1127744006079 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1127744006080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744006081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744006082 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1127744006083 putative dimerization interface [polypeptide binding]; other site 1127744006084 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1127744006085 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1127744006086 NAD(P) binding site [chemical binding]; other site 1127744006087 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1127744006088 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1127744006089 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1127744006090 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1127744006091 active site 1127744006092 dimer interface [polypeptide binding]; other site 1127744006093 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1127744006094 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1127744006095 active site 1127744006096 FMN binding site [chemical binding]; other site 1127744006097 substrate binding site [chemical binding]; other site 1127744006098 3Fe-4S cluster binding site [ion binding]; other site 1127744006099 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1127744006100 domain interface; other site 1127744006101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744006102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744006103 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1127744006104 putative dimerization interface [polypeptide binding]; other site 1127744006105 gamma-glutamyl kinase; Provisional; Region: PRK13402 1127744006106 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1127744006107 nucleotide binding site [chemical binding]; other site 1127744006108 homotetrameric interface [polypeptide binding]; other site 1127744006109 putative phosphate binding site [ion binding]; other site 1127744006110 putative allosteric binding site; other site 1127744006111 PUA domain; Region: PUA; pfam01472 1127744006112 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1127744006113 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1127744006114 Replication terminator protein; Region: RTP; pfam02334 1127744006115 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1127744006116 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1127744006117 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1127744006118 polyol permease family; Region: 2A0118; TIGR00897 1127744006119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744006120 putative substrate translocation pore; other site 1127744006121 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1127744006122 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 1127744006123 putative N- and C-terminal domain interface [polypeptide binding]; other site 1127744006124 putative active site [active] 1127744006125 putative MgATP binding site [chemical binding]; other site 1127744006126 catalytic site [active] 1127744006127 metal binding site [ion binding]; metal-binding site 1127744006128 carbohydrate binding site [chemical binding]; other site 1127744006129 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1127744006130 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1127744006131 putative ligand binding site [chemical binding]; other site 1127744006132 putative NAD binding site [chemical binding]; other site 1127744006133 catalytic site [active] 1127744006134 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1127744006135 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1127744006136 putative [4Fe-4S] binding site [ion binding]; other site 1127744006137 putative molybdopterin cofactor binding site [chemical binding]; other site 1127744006138 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1127744006139 putative molybdopterin cofactor binding site; other site 1127744006140 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 1127744006141 CHASE3 domain; Region: CHASE3; cl05000 1127744006142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744006143 dimerization interface [polypeptide binding]; other site 1127744006144 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1127744006145 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1127744006146 dimer interface [polypeptide binding]; other site 1127744006147 putative CheW interface [polypeptide binding]; other site 1127744006148 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1127744006149 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1127744006150 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 1127744006151 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1127744006152 Predicted membrane protein [Function unknown]; Region: COG3619 1127744006153 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1127744006154 Amb_all domain; Region: Amb_all; smart00656 1127744006155 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1127744006156 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1127744006157 Cupin; Region: Cupin_1; smart00835 1127744006158 Cupin; Region: Cupin_1; smart00835 1127744006159 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1127744006160 Coenzyme A binding pocket [chemical binding]; other site 1127744006161 YoaP-like; Region: YoaP; pfam14268 1127744006162 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1127744006163 VanW like protein; Region: VanW; pfam04294 1127744006164 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1127744006165 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127744006166 salt bridge; other site 1127744006167 non-specific DNA binding site [nucleotide binding]; other site 1127744006168 sequence-specific DNA binding site [nucleotide binding]; other site 1127744006169 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 1127744006170 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744006171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744006172 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1127744006173 dimerization interface [polypeptide binding]; other site 1127744006174 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1127744006175 EamA-like transporter family; Region: EamA; pfam00892 1127744006176 EamA-like transporter family; Region: EamA; pfam00892 1127744006177 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 1127744006178 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1127744006179 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1127744006180 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1127744006181 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1127744006182 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1127744006183 CAAX protease self-immunity; Region: Abi; pfam02517 1127744006184 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1127744006185 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 1127744006186 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1127744006187 short chain dehydrogenase; Provisional; Region: PRK06500 1127744006188 classical (c) SDRs; Region: SDR_c; cd05233 1127744006189 NAD(P) binding site [chemical binding]; other site 1127744006190 active site 1127744006191 Predicted transcriptional regulators [Transcription]; Region: COG1733 1127744006192 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1127744006193 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1127744006194 dimer interface [polypeptide binding]; other site 1127744006195 putative tRNA-binding site [nucleotide binding]; other site 1127744006196 Cupin domain; Region: Cupin_2; pfam07883 1127744006197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127744006198 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127744006199 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744006200 Coenzyme A binding pocket [chemical binding]; other site 1127744006201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744006202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744006203 WHG domain; Region: WHG; pfam13305 1127744006204 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1127744006205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1127744006206 Predicted transcriptional regulator [Transcription]; Region: COG2378 1127744006207 HTH domain; Region: HTH_11; pfam08279 1127744006208 WYL domain; Region: WYL; pfam13280 1127744006209 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127744006210 dimerization interface [polypeptide binding]; other site 1127744006211 putative DNA binding site [nucleotide binding]; other site 1127744006212 putative Zn2+ binding site [ion binding]; other site 1127744006213 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1127744006214 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1127744006215 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1127744006216 catalytic residue [active] 1127744006217 Predicted membrane protein [Function unknown]; Region: COG2322 1127744006218 Protein required for attachment to host cells; Region: Host_attach; cl02398 1127744006219 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1127744006220 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1127744006221 putative dimer interface [polypeptide binding]; other site 1127744006222 catalytic triad [active] 1127744006223 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1127744006224 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1127744006225 putative di-iron ligands [ion binding]; other site 1127744006226 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127744006227 Histidine kinase; Region: HisKA_3; pfam07730 1127744006228 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1127744006229 ATP binding site [chemical binding]; other site 1127744006230 Mg2+ binding site [ion binding]; other site 1127744006231 G-X-G motif; other site 1127744006232 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127744006233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744006234 active site 1127744006235 phosphorylation site [posttranslational modification] 1127744006236 intermolecular recognition site; other site 1127744006237 dimerization interface [polypeptide binding]; other site 1127744006238 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127744006239 DNA binding residues [nucleotide binding] 1127744006240 dimerization interface [polypeptide binding]; other site 1127744006241 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744006242 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1127744006243 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744006244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1127744006245 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1127744006246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127744006247 ATP binding site [chemical binding]; other site 1127744006248 putative Mg++ binding site [ion binding]; other site 1127744006249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127744006250 nucleotide binding region [chemical binding]; other site 1127744006251 ATP-binding site [chemical binding]; other site 1127744006252 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1127744006253 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1127744006254 azoreductase; Provisional; Region: PRK13556 1127744006255 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1127744006256 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1127744006257 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1127744006258 putative dimer interface [polypeptide binding]; other site 1127744006259 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1127744006260 pentamer interface [polypeptide binding]; other site 1127744006261 dodecaamer interface [polypeptide binding]; other site 1127744006262 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1127744006263 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127744006264 NAD(P) binding site [chemical binding]; other site 1127744006265 catalytic residues [active] 1127744006266 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1127744006267 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1127744006268 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1127744006269 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1127744006270 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1127744006271 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1127744006272 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1127744006273 Na2 binding site [ion binding]; other site 1127744006274 putative substrate binding site 1 [chemical binding]; other site 1127744006275 Na binding site 1 [ion binding]; other site 1127744006276 putative substrate binding site 2 [chemical binding]; other site 1127744006277 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1127744006278 Sodium Bile acid symporter family; Region: SBF; pfam01758 1127744006279 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1127744006280 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1127744006281 E3 interaction surface; other site 1127744006282 lipoyl attachment site [posttranslational modification]; other site 1127744006283 e3 binding domain; Region: E3_binding; pfam02817 1127744006284 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1127744006285 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1127744006286 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1127744006287 TPP-binding site [chemical binding]; other site 1127744006288 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1127744006289 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1127744006290 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1127744006291 metal ion-dependent adhesion site (MIDAS); other site 1127744006292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744006293 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1127744006294 Walker A motif; other site 1127744006295 ATP binding site [chemical binding]; other site 1127744006296 Walker B motif; other site 1127744006297 arginine finger; other site 1127744006298 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1127744006299 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1127744006300 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 1127744006301 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1127744006302 E-class dimer interface [polypeptide binding]; other site 1127744006303 P-class dimer interface [polypeptide binding]; other site 1127744006304 active site 1127744006305 Cu2+ binding site [ion binding]; other site 1127744006306 Zn2+ binding site [ion binding]; other site 1127744006307 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744006308 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744006309 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744006310 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744006311 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1127744006312 NlpC/P60 family; Region: NLPC_P60; pfam00877 1127744006313 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1127744006314 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1127744006315 active site 1127744006316 TDP-binding site; other site 1127744006317 acceptor substrate-binding pocket; other site 1127744006318 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1127744006319 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1127744006320 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1127744006321 multidrug efflux protein; Reviewed; Region: PRK01766 1127744006322 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1127744006323 cation binding site [ion binding]; other site 1127744006324 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1127744006325 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1127744006326 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1127744006327 rarD protein; Region: rarD; TIGR00688 1127744006328 EamA-like transporter family; Region: EamA; pfam00892 1127744006329 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1127744006330 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1127744006331 Tautomerase enzyme; Region: Tautomerase; pfam01361 1127744006332 Predicted transcriptional regulators [Transcription]; Region: COG1733 1127744006333 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127744006334 dimerization interface [polypeptide binding]; other site 1127744006335 putative DNA binding site [nucleotide binding]; other site 1127744006336 putative Zn2+ binding site [ion binding]; other site 1127744006337 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1127744006338 dimer interface [polypeptide binding]; other site 1127744006339 FMN binding site [chemical binding]; other site 1127744006340 Predicted esterase [General function prediction only]; Region: COG0400 1127744006341 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1127744006342 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1127744006343 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1127744006344 Na binding site [ion binding]; other site 1127744006345 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1127744006346 C-terminal peptidase (prc); Region: prc; TIGR00225 1127744006347 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1127744006348 protein binding site [polypeptide binding]; other site 1127744006349 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1127744006350 Catalytic dyad [active] 1127744006351 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1127744006352 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1127744006353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744006354 S-adenosylmethionine binding site [chemical binding]; other site 1127744006355 Prokaryotic E2 family A; Region: Prok-E2_A; pfam14457 1127744006356 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1127744006357 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1127744006358 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1127744006359 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1127744006360 YodL-like; Region: YodL; pfam14191 1127744006361 YozD-like protein; Region: YozD; pfam14162 1127744006362 hypothetical protein; Provisional; Region: PRK13672 1127744006363 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1127744006364 toxin interface [polypeptide binding]; other site 1127744006365 Zn binding site [ion binding]; other site 1127744006366 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1127744006367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127744006368 FeS/SAM binding site; other site 1127744006369 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1127744006370 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1127744006371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744006372 Coenzyme A binding pocket [chemical binding]; other site 1127744006373 acetylornithine deacetylase; Validated; Region: PRK06915 1127744006374 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1127744006375 metal binding site [ion binding]; metal-binding site 1127744006376 dimer interface [polypeptide binding]; other site 1127744006377 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1127744006378 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1127744006379 hypothetical protein; Provisional; Region: PRK06917 1127744006380 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127744006381 inhibitor-cofactor binding pocket; inhibition site 1127744006382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744006383 catalytic residue [active] 1127744006384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744006385 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1127744006386 Coenzyme A binding pocket [chemical binding]; other site 1127744006387 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1127744006388 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1127744006389 active site 1127744006390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1127744006391 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1127744006392 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1127744006393 Phytase; Region: Phytase; cl17685 1127744006394 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1127744006395 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1127744006396 NAD(P) binding site [chemical binding]; other site 1127744006397 homodimer interface [polypeptide binding]; other site 1127744006398 substrate binding site [chemical binding]; other site 1127744006399 active site 1127744006400 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1127744006401 SelR domain; Region: SelR; pfam01641 1127744006402 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1127744006403 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744006404 MarR family; Region: MarR; pfam01047 1127744006405 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1127744006406 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1127744006407 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 1127744006408 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1127744006409 active site 1127744006410 catalytic triad [active] 1127744006411 oxyanion hole [active] 1127744006412 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1127744006413 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1127744006414 Cu(I) binding site [ion binding]; other site 1127744006415 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1127744006416 threonine dehydratase; Validated; Region: PRK08639 1127744006417 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1127744006418 tetramer interface [polypeptide binding]; other site 1127744006419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744006420 catalytic residue [active] 1127744006421 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1127744006422 putative Ile/Val binding site [chemical binding]; other site 1127744006423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744006424 Walker A motif; other site 1127744006425 ATP binding site [chemical binding]; other site 1127744006426 Walker B motif; other site 1127744006427 arginine finger; other site 1127744006428 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1127744006429 Haemolysin-III related; Region: HlyIII; cl03831 1127744006430 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1127744006431 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1127744006432 putative acyl-acceptor binding pocket; other site 1127744006433 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1127744006434 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1127744006435 folate binding site [chemical binding]; other site 1127744006436 NADP+ binding site [chemical binding]; other site 1127744006437 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1127744006438 tetramer interfaces [polypeptide binding]; other site 1127744006439 binuclear metal-binding site [ion binding]; other site 1127744006440 ribosomal biogenesis protein; Validated; Region: PRK00933 1127744006441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744006442 S-adenosylmethionine binding site [chemical binding]; other site 1127744006443 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1127744006444 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1127744006445 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1127744006446 Virulence factor; Region: Virulence_fact; pfam13769 1127744006447 HEAT repeats; Region: HEAT_2; pfam13646 1127744006448 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1127744006449 HEAT repeats; Region: HEAT_2; pfam13646 1127744006450 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1127744006451 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1127744006452 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1127744006453 Zn2+ binding site [ion binding]; other site 1127744006454 Mg2+ binding site [ion binding]; other site 1127744006455 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1127744006456 catalytic residues [active] 1127744006457 dimer interface [polypeptide binding]; other site 1127744006458 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1127744006459 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1127744006460 proposed active site lysine [active] 1127744006461 conserved cys residue [active] 1127744006462 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1127744006463 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1127744006464 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1127744006465 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1127744006466 DNA-binding site [nucleotide binding]; DNA binding site 1127744006467 RNA-binding motif; other site 1127744006468 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1127744006469 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1127744006470 hypothetical protein; Validated; Region: PRK07708 1127744006471 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1127744006472 RNA/DNA hybrid binding site [nucleotide binding]; other site 1127744006473 active site 1127744006474 conserved hypothetical integral membrane protein; Region: TIGR00697 1127744006475 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1127744006476 RNA/DNA hybrid binding site [nucleotide binding]; other site 1127744006477 active site 1127744006478 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1127744006479 5'-3' exonuclease; Region: 53EXOc; smart00475 1127744006480 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1127744006481 active site 1127744006482 metal binding site 1 [ion binding]; metal-binding site 1127744006483 putative 5' ssDNA interaction site; other site 1127744006484 metal binding site 3; metal-binding site 1127744006485 metal binding site 2 [ion binding]; metal-binding site 1127744006486 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1127744006487 putative DNA binding site [nucleotide binding]; other site 1127744006488 putative metal binding site [ion binding]; other site 1127744006489 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1127744006490 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1127744006491 Dynamin family; Region: Dynamin_N; pfam00350 1127744006492 G1 box; other site 1127744006493 GTP/Mg2+ binding site [chemical binding]; other site 1127744006494 G2 box; other site 1127744006495 Switch I region; other site 1127744006496 G3 box; other site 1127744006497 Switch II region; other site 1127744006498 G4 box; other site 1127744006499 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1127744006500 G1 box; other site 1127744006501 GTP/Mg2+ binding site [chemical binding]; other site 1127744006502 Dynamin family; Region: Dynamin_N; pfam00350 1127744006503 G2 box; other site 1127744006504 Switch I region; other site 1127744006505 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1127744006506 G3 box; other site 1127744006507 Switch II region; other site 1127744006508 GTP/Mg2+ binding site [chemical binding]; other site 1127744006509 G4 box; other site 1127744006510 G5 box; other site 1127744006511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1127744006512 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1127744006513 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1127744006514 malonyl-CoA binding site [chemical binding]; other site 1127744006515 dimer interface [polypeptide binding]; other site 1127744006516 active site 1127744006517 product binding site; other site 1127744006518 xanthine permease; Region: pbuX; TIGR03173 1127744006519 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1127744006520 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127744006521 active site 1127744006522 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1127744006523 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1127744006524 active site 1127744006525 Zn binding site [ion binding]; other site 1127744006526 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1127744006527 Entner-Doudoroff aldolase; Region: eda; TIGR01182 1127744006528 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1127744006529 active site 1127744006530 intersubunit interface [polypeptide binding]; other site 1127744006531 catalytic residue [active] 1127744006532 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1127744006533 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1127744006534 substrate binding site [chemical binding]; other site 1127744006535 ATP binding site [chemical binding]; other site 1127744006536 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1127744006537 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1127744006538 DNA binding site [nucleotide binding] 1127744006539 domain linker motif; other site 1127744006540 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1127744006541 putative dimerization interface [polypeptide binding]; other site 1127744006542 putative ligand binding site [chemical binding]; other site 1127744006543 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1127744006544 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1127744006545 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1127744006546 NADP binding site [chemical binding]; other site 1127744006547 homodimer interface [polypeptide binding]; other site 1127744006548 active site 1127744006549 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1127744006550 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1127744006551 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1127744006552 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1127744006553 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1127744006554 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1127744006555 cell division protein GpsB; Provisional; Region: PRK14127 1127744006556 DivIVA domain; Region: DivI1A_domain; TIGR03544 1127744006557 hypothetical protein; Provisional; Region: PRK13660 1127744006558 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 1127744006559 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1127744006560 RNase_H superfamily; Region: RNase_H_2; pfam13482 1127744006561 active site 1127744006562 substrate binding site [chemical binding]; other site 1127744006563 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1127744006564 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1127744006565 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127744006566 ATP binding site [chemical binding]; other site 1127744006567 putative Mg++ binding site [ion binding]; other site 1127744006568 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127744006569 nucleotide binding region [chemical binding]; other site 1127744006570 ATP-binding site [chemical binding]; other site 1127744006571 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1127744006572 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1127744006573 HPr interaction site; other site 1127744006574 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1127744006575 active site 1127744006576 phosphorylation site [posttranslational modification] 1127744006577 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1127744006578 YppG-like protein; Region: YppG; pfam14179 1127744006579 YppF-like protein; Region: YppF; pfam14178 1127744006580 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1127744006581 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1127744006582 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1127744006583 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1127744006584 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1127744006585 Transglycosylase; Region: Transgly; pfam00912 1127744006586 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1127744006587 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1127744006588 Interdomain contacts; other site 1127744006589 Cytokine receptor motif; other site 1127744006590 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1127744006591 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1127744006592 minor groove reading motif; other site 1127744006593 helix-hairpin-helix signature motif; other site 1127744006594 substrate binding pocket [chemical binding]; other site 1127744006595 active site 1127744006596 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1127744006597 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1127744006598 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1127744006599 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1127744006600 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1127744006601 putative dimer interface [polypeptide binding]; other site 1127744006602 putative anticodon binding site; other site 1127744006603 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1127744006604 homodimer interface [polypeptide binding]; other site 1127744006605 motif 1; other site 1127744006606 motif 2; other site 1127744006607 active site 1127744006608 motif 3; other site 1127744006609 aspartate aminotransferase; Provisional; Region: PRK05764 1127744006610 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127744006611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744006612 homodimer interface [polypeptide binding]; other site 1127744006613 catalytic residue [active] 1127744006614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1127744006615 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1127744006616 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1127744006617 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1127744006618 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1127744006619 active site 1127744006620 catalytic site [active] 1127744006621 substrate binding site [chemical binding]; other site 1127744006622 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1127744006623 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1127744006624 tetramerization interface [polypeptide binding]; other site 1127744006625 active site 1127744006626 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1127744006627 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1127744006628 active site 1127744006629 ATP-binding site [chemical binding]; other site 1127744006630 pantoate-binding site; other site 1127744006631 HXXH motif; other site 1127744006632 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1127744006633 oligomerization interface [polypeptide binding]; other site 1127744006634 active site 1127744006635 metal binding site [ion binding]; metal-binding site 1127744006636 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1127744006637 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1127744006638 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1127744006639 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1127744006640 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1127744006641 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1127744006642 active site 1127744006643 NTP binding site [chemical binding]; other site 1127744006644 metal binding triad [ion binding]; metal-binding site 1127744006645 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1127744006646 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1127744006647 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1127744006648 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1127744006649 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1127744006650 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1127744006651 active site 1127744006652 dimer interfaces [polypeptide binding]; other site 1127744006653 catalytic residues [active] 1127744006654 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1127744006655 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1127744006656 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1127744006657 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1127744006658 homodimer interface [polypeptide binding]; other site 1127744006659 metal binding site [ion binding]; metal-binding site 1127744006660 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1127744006661 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127744006662 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127744006663 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1127744006664 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 1127744006665 Predicted membrane protein [Function unknown]; Region: COG4347 1127744006666 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1127744006667 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1127744006668 intrachain domain interface; other site 1127744006669 Qi binding site; other site 1127744006670 Qo binding site; other site 1127744006671 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1127744006672 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1127744006673 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1127744006674 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1127744006675 interchain domain interface [polypeptide binding]; other site 1127744006676 intrachain domain interface; other site 1127744006677 heme bH binding site [chemical binding]; other site 1127744006678 Qi binding site; other site 1127744006679 heme bL binding site [chemical binding]; other site 1127744006680 Qo binding site; other site 1127744006681 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1127744006682 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1127744006683 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1127744006684 iron-sulfur cluster [ion binding]; other site 1127744006685 [2Fe-2S] cluster binding site [ion binding]; other site 1127744006686 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1127744006687 hypothetical protein; Provisional; Region: PRK03636 1127744006688 UPF0302 domain; Region: UPF0302; pfam08864 1127744006689 IDEAL domain; Region: IDEAL; pfam08858 1127744006690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744006691 TPR motif; other site 1127744006692 binding surface 1127744006693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744006694 binding surface 1127744006695 TPR motif; other site 1127744006696 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1127744006697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744006698 TPR motif; other site 1127744006699 binding surface 1127744006700 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1127744006701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744006702 binding surface 1127744006703 TPR motif; other site 1127744006704 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1127744006705 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1127744006706 hinge; other site 1127744006707 active site 1127744006708 prephenate dehydrogenase; Validated; Region: PRK06545 1127744006709 prephenate dehydrogenase; Validated; Region: PRK08507 1127744006710 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1127744006711 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1127744006712 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127744006713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744006714 homodimer interface [polypeptide binding]; other site 1127744006715 catalytic residue [active] 1127744006716 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1127744006717 substrate binding site [chemical binding]; other site 1127744006718 active site 1127744006719 catalytic residues [active] 1127744006720 heterodimer interface [polypeptide binding]; other site 1127744006721 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1127744006722 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1127744006723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744006724 catalytic residue [active] 1127744006725 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1127744006726 active site 1127744006727 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1127744006728 active site 1127744006729 ribulose/triose binding site [chemical binding]; other site 1127744006730 phosphate binding site [ion binding]; other site 1127744006731 substrate (anthranilate) binding pocket [chemical binding]; other site 1127744006732 product (indole) binding pocket [chemical binding]; other site 1127744006733 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1127744006734 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1127744006735 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1127744006736 anthranilate synthase component I; Provisional; Region: PRK13569 1127744006737 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1127744006738 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1127744006739 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1127744006740 homotrimer interaction site [polypeptide binding]; other site 1127744006741 active site 1127744006742 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1127744006743 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1127744006744 active site 1127744006745 dimer interface [polypeptide binding]; other site 1127744006746 metal binding site [ion binding]; metal-binding site 1127744006747 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1127744006748 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1127744006749 Tetramer interface [polypeptide binding]; other site 1127744006750 active site 1127744006751 FMN-binding site [chemical binding]; other site 1127744006752 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1127744006753 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1127744006754 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1127744006755 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1127744006756 active site 1127744006757 multimer interface [polypeptide binding]; other site 1127744006758 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1127744006759 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1127744006760 substrate binding pocket [chemical binding]; other site 1127744006761 chain length determination region; other site 1127744006762 substrate-Mg2+ binding site; other site 1127744006763 catalytic residues [active] 1127744006764 aspartate-rich region 1; other site 1127744006765 active site lid residues [active] 1127744006766 aspartate-rich region 2; other site 1127744006767 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1127744006768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744006769 S-adenosylmethionine binding site [chemical binding]; other site 1127744006770 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1127744006771 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 1127744006772 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1127744006773 homodecamer interface [polypeptide binding]; other site 1127744006774 GTP cyclohydrolase I; Provisional; Region: PLN03044 1127744006775 active site 1127744006776 putative catalytic site residues [active] 1127744006777 zinc binding site [ion binding]; other site 1127744006778 GTP-CH-I/GFRP interaction surface; other site 1127744006779 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1127744006780 IHF dimer interface [polypeptide binding]; other site 1127744006781 IHF - DNA interface [nucleotide binding]; other site 1127744006782 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1127744006783 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1127744006784 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1127744006785 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1127744006786 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1127744006787 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1127744006788 GTP-binding protein Der; Reviewed; Region: PRK00093 1127744006789 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1127744006790 G1 box; other site 1127744006791 GTP/Mg2+ binding site [chemical binding]; other site 1127744006792 Switch I region; other site 1127744006793 G2 box; other site 1127744006794 Switch II region; other site 1127744006795 G3 box; other site 1127744006796 G4 box; other site 1127744006797 G5 box; other site 1127744006798 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1127744006799 G1 box; other site 1127744006800 GTP/Mg2+ binding site [chemical binding]; other site 1127744006801 Switch I region; other site 1127744006802 G2 box; other site 1127744006803 G3 box; other site 1127744006804 Switch II region; other site 1127744006805 G4 box; other site 1127744006806 G5 box; other site 1127744006807 YIEGIA protein; Region: YIEGIA; pfam14045 1127744006808 YpzI-like protein; Region: YpzI; pfam14140 1127744006809 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1127744006810 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1127744006811 homotetramer interface [polypeptide binding]; other site 1127744006812 FMN binding site [chemical binding]; other site 1127744006813 homodimer contacts [polypeptide binding]; other site 1127744006814 putative active site [active] 1127744006815 putative substrate binding site [chemical binding]; other site 1127744006816 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1127744006817 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1127744006818 RNA binding site [nucleotide binding]; other site 1127744006819 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1127744006820 RNA binding site [nucleotide binding]; other site 1127744006821 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1127744006822 RNA binding site [nucleotide binding]; other site 1127744006823 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1127744006824 RNA binding site [nucleotide binding]; other site 1127744006825 cytidylate kinase; Provisional; Region: cmk; PRK00023 1127744006826 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1127744006827 CMP-binding site; other site 1127744006828 The sites determining sugar specificity; other site 1127744006829 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1127744006830 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1127744006831 PilZ domain; Region: PilZ; pfam07238 1127744006832 germination protein YpeB; Region: spore_YpeB; TIGR02889 1127744006833 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1127744006834 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1127744006835 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1127744006836 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1127744006837 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1127744006838 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127744006839 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1127744006840 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1127744006841 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1127744006842 NAD(P) binding site [chemical binding]; other site 1127744006843 adaptor protein; Provisional; Region: PRK02899 1127744006844 phosphodiesterase YaeI; Provisional; Region: PRK11340 1127744006845 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1127744006846 putative active site [active] 1127744006847 putative metal binding site [ion binding]; other site 1127744006848 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1127744006849 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744006850 CAAX protease self-immunity; Region: Abi; pfam02517 1127744006851 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1127744006852 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127744006853 ATP binding site [chemical binding]; other site 1127744006854 putative Mg++ binding site [ion binding]; other site 1127744006855 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127744006856 nucleotide binding region [chemical binding]; other site 1127744006857 ATP-binding site [chemical binding]; other site 1127744006858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1127744006859 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1127744006860 Predicted membrane protein [Function unknown]; Region: COG3601 1127744006861 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1127744006862 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1127744006863 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1127744006864 ligand binding site [chemical binding]; other site 1127744006865 NAD binding site [chemical binding]; other site 1127744006866 dimerization interface [polypeptide binding]; other site 1127744006867 catalytic site [active] 1127744006868 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1127744006869 putative L-serine binding site [chemical binding]; other site 1127744006870 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1127744006871 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1127744006872 active site 1127744006873 catalytic residue [active] 1127744006874 dimer interface [polypeptide binding]; other site 1127744006875 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1127744006876 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744006877 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744006878 DNA binding residues [nucleotide binding] 1127744006879 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1127744006880 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744006881 dimerization interface [polypeptide binding]; other site 1127744006882 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1127744006883 putative active site [active] 1127744006884 heme pocket [chemical binding]; other site 1127744006885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744006886 dimer interface [polypeptide binding]; other site 1127744006887 phosphorylation site [posttranslational modification] 1127744006888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744006889 ATP binding site [chemical binding]; other site 1127744006890 Mg2+ binding site [ion binding]; other site 1127744006891 G-X-G motif; other site 1127744006892 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127744006893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744006894 active site 1127744006895 phosphorylation site [posttranslational modification] 1127744006896 intermolecular recognition site; other site 1127744006897 dimerization interface [polypeptide binding]; other site 1127744006898 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127744006899 DNA binding site [nucleotide binding] 1127744006900 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1127744006901 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1127744006902 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1127744006903 ResB-like family; Region: ResB; pfam05140 1127744006904 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1127744006905 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1127744006906 catalytic residues [active] 1127744006907 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1127744006908 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127744006909 RNA binding surface [nucleotide binding]; other site 1127744006910 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1127744006911 active site 1127744006912 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1127744006913 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1127744006914 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1127744006915 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1127744006916 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1127744006917 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1127744006918 segregation and condensation protein B; Region: TIGR00281 1127744006919 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1127744006920 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547 1127744006921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744006922 Coenzyme A binding pocket [chemical binding]; other site 1127744006923 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1127744006924 homopentamer interface [polypeptide binding]; other site 1127744006925 active site 1127744006926 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1127744006927 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1127744006928 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1127744006929 dimerization interface [polypeptide binding]; other site 1127744006930 active site 1127744006931 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1127744006932 Lumazine binding domain; Region: Lum_binding; pfam00677 1127744006933 Lumazine binding domain; Region: Lum_binding; pfam00677 1127744006934 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1127744006935 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1127744006936 catalytic motif [active] 1127744006937 Zn binding site [ion binding]; other site 1127744006938 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1127744006939 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1127744006940 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1127744006941 Catalytic site [active] 1127744006942 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 1127744006943 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1127744006944 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1127744006945 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1127744006946 active site 1127744006947 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1127744006948 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1127744006949 active site 1127744006950 Predicted secreted protein [Function unknown]; Region: COG4086 1127744006951 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1127744006952 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1127744006953 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1127744006954 active site 1127744006955 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1127744006956 substrate binding site [chemical binding]; other site 1127744006957 catalytic residues [active] 1127744006958 dimer interface [polypeptide binding]; other site 1127744006959 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1127744006960 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1127744006961 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1127744006962 stage V sporulation protein AD; Validated; Region: PRK08304 1127744006963 stage V sporulation protein AD; Provisional; Region: PRK12404 1127744006964 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1127744006965 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1127744006966 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1127744006967 sporulation sigma factor SigF; Validated; Region: PRK05572 1127744006968 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744006969 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1127744006970 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744006971 DNA binding residues [nucleotide binding] 1127744006972 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1127744006973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744006974 ATP binding site [chemical binding]; other site 1127744006975 Mg2+ binding site [ion binding]; other site 1127744006976 G-X-G motif; other site 1127744006977 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1127744006978 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1127744006979 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1127744006980 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1127744006981 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1127744006982 phosphopentomutase; Provisional; Region: PRK05362 1127744006983 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1127744006984 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1127744006985 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1127744006986 active site 1127744006987 Int/Topo IB signature motif; other site 1127744006988 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1127744006989 ferric uptake regulator; Provisional; Region: fur; PRK09462 1127744006990 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1127744006991 metal binding site 2 [ion binding]; metal-binding site 1127744006992 putative DNA binding helix; other site 1127744006993 metal binding site 1 [ion binding]; metal-binding site 1127744006994 dimer interface [polypeptide binding]; other site 1127744006995 structural Zn2+ binding site [ion binding]; other site 1127744006996 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1127744006997 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1127744006998 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1127744006999 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1127744007000 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1127744007001 NAD(P) binding pocket [chemical binding]; other site 1127744007002 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1127744007003 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1127744007004 Aspartase; Region: Aspartase; cd01357 1127744007005 active sites [active] 1127744007006 tetramer interface [polypeptide binding]; other site 1127744007007 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1127744007008 active site 1127744007009 homodimer interface [polypeptide binding]; other site 1127744007010 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127744007011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127744007012 non-specific DNA binding site [nucleotide binding]; other site 1127744007013 salt bridge; other site 1127744007014 sequence-specific DNA binding site [nucleotide binding]; other site 1127744007015 TIGR00375 family protein; Region: TIGR00375 1127744007016 PHP-associated; Region: PHP_C; pfam13263 1127744007017 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1127744007018 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1127744007019 dimer interface [polypeptide binding]; other site 1127744007020 ADP-ribose binding site [chemical binding]; other site 1127744007021 active site 1127744007022 nudix motif; other site 1127744007023 metal binding site [ion binding]; metal-binding site 1127744007024 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1127744007025 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1127744007026 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1127744007027 active site 1127744007028 catalytic tetrad [active] 1127744007029 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1127744007030 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1127744007031 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 1127744007032 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1127744007033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1127744007034 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1127744007035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744007036 Coenzyme A binding pocket [chemical binding]; other site 1127744007037 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1127744007038 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1127744007039 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1127744007040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744007041 Coenzyme A binding pocket [chemical binding]; other site 1127744007042 YolD-like protein; Region: YolD; pfam08863 1127744007043 DNA polymerase IV; Reviewed; Region: PRK03103 1127744007044 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1127744007045 active site 1127744007046 DNA binding site [nucleotide binding] 1127744007047 YqzH-like protein; Region: YqzH; pfam14164 1127744007048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744007049 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744007050 putative substrate translocation pore; other site 1127744007051 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1127744007052 putative dimer interface [polypeptide binding]; other site 1127744007053 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127744007054 ligand binding site [chemical binding]; other site 1127744007055 Zn binding site [ion binding]; other site 1127744007056 pantothenate kinase; Provisional; Region: PRK05439 1127744007057 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1127744007058 ATP-binding site [chemical binding]; other site 1127744007059 CoA-binding site [chemical binding]; other site 1127744007060 Mg2+-binding site [ion binding]; other site 1127744007061 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1127744007062 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1127744007063 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127744007064 catalytic residue [active] 1127744007065 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1127744007066 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 1127744007067 NADP binding site [chemical binding]; other site 1127744007068 homodimer interface [polypeptide binding]; other site 1127744007069 substrate binding site [chemical binding]; other site 1127744007070 active site 1127744007071 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1127744007072 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1127744007073 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1127744007074 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1127744007075 putative metal binding site [ion binding]; other site 1127744007076 putative dimer interface [polypeptide binding]; other site 1127744007077 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1127744007078 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1127744007079 active site 1127744007080 FMN binding site [chemical binding]; other site 1127744007081 substrate binding site [chemical binding]; other site 1127744007082 homotetramer interface [polypeptide binding]; other site 1127744007083 catalytic residue [active] 1127744007084 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1127744007085 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1127744007086 putative hydrolase; Provisional; Region: PRK02113 1127744007087 ribonuclease Z; Region: RNase_Z; TIGR02651 1127744007088 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1127744007089 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1127744007090 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1127744007091 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1127744007092 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1127744007093 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1127744007094 DNA polymerase IV; Validated; Region: PRK01810 1127744007095 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1127744007096 active site 1127744007097 DNA binding site [nucleotide binding] 1127744007098 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1127744007099 OxaA-like protein precursor; Validated; Region: PRK01622 1127744007100 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1127744007101 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 1127744007102 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1127744007103 peptidase T-like protein; Region: PepT-like; TIGR01883 1127744007104 metal binding site [ion binding]; metal-binding site 1127744007105 putative dimer interface [polypeptide binding]; other site 1127744007106 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1127744007107 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1127744007108 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1127744007109 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127744007110 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1127744007111 dimer interface [polypeptide binding]; other site 1127744007112 substrate binding site [chemical binding]; other site 1127744007113 metal binding site [ion binding]; metal-binding site 1127744007114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1127744007115 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1127744007116 Predicted membrane protein [Function unknown]; Region: COG4129 1127744007117 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1127744007118 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1127744007119 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1127744007120 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1127744007121 Walker A/P-loop; other site 1127744007122 ATP binding site [chemical binding]; other site 1127744007123 Q-loop/lid; other site 1127744007124 ABC transporter signature motif; other site 1127744007125 Walker B; other site 1127744007126 D-loop; other site 1127744007127 H-loop/switch region; other site 1127744007128 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1127744007129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744007130 dimer interface [polypeptide binding]; other site 1127744007131 conserved gate region; other site 1127744007132 putative PBP binding loops; other site 1127744007133 ABC-ATPase subunit interface; other site 1127744007134 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1127744007135 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1127744007136 substrate binding pocket [chemical binding]; other site 1127744007137 membrane-bound complex binding site; other site 1127744007138 hinge residues; other site 1127744007139 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1127744007140 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1127744007141 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1127744007142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744007143 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744007144 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1127744007145 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127744007146 DNA binding residues [nucleotide binding] 1127744007147 drug binding residues [chemical binding]; other site 1127744007148 dimer interface [polypeptide binding]; other site 1127744007149 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1127744007150 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1127744007151 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1127744007152 E3 interaction surface; other site 1127744007153 lipoyl attachment site [posttranslational modification]; other site 1127744007154 e3 binding domain; Region: E3_binding; pfam02817 1127744007155 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1127744007156 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1127744007157 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1127744007158 tetramer interface [polypeptide binding]; other site 1127744007159 TPP-binding site [chemical binding]; other site 1127744007160 heterodimer interface [polypeptide binding]; other site 1127744007161 phosphorylation loop region [posttranslational modification] 1127744007162 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1127744007163 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1127744007164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127744007165 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1127744007166 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1127744007167 nucleotide binding site [chemical binding]; other site 1127744007168 Acetokinase family; Region: Acetate_kinase; cl17229 1127744007169 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1127744007170 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1127744007171 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1127744007172 NAD binding site [chemical binding]; other site 1127744007173 Phe binding site; other site 1127744007174 phosphate butyryltransferase; Validated; Region: PRK07742 1127744007175 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1127744007176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1127744007177 putative active site [active] 1127744007178 heme pocket [chemical binding]; other site 1127744007179 PAS domain; Region: PAS; smart00091 1127744007180 putative active site [active] 1127744007181 heme pocket [chemical binding]; other site 1127744007182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744007183 Walker A motif; other site 1127744007184 ATP binding site [chemical binding]; other site 1127744007185 Walker B motif; other site 1127744007186 arginine finger; other site 1127744007187 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1127744007188 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1127744007189 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1127744007190 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1127744007191 tetramer interface [polypeptide binding]; other site 1127744007192 active site 1127744007193 Mg2+/Mn2+ binding site [ion binding]; other site 1127744007194 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1127744007195 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1127744007196 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1127744007197 dimer interface [polypeptide binding]; other site 1127744007198 Citrate synthase; Region: Citrate_synt; pfam00285 1127744007199 active site 1127744007200 coenzyme A binding site [chemical binding]; other site 1127744007201 citrylCoA binding site [chemical binding]; other site 1127744007202 oxalacetate/citrate binding site [chemical binding]; other site 1127744007203 catalytic triad [active] 1127744007204 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127744007205 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127744007206 active site 1127744007207 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1127744007208 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1127744007209 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1127744007210 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1127744007211 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1127744007212 dimer interface [polypeptide binding]; other site 1127744007213 active site 1127744007214 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1127744007215 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1127744007216 active site 1127744007217 catalytic site [active] 1127744007218 metal binding site [ion binding]; metal-binding site 1127744007219 dimer interface [polypeptide binding]; other site 1127744007220 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1127744007221 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1127744007222 active site 1127744007223 metal binding site [ion binding]; metal-binding site 1127744007224 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1127744007225 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1127744007226 putative active site [active] 1127744007227 putative FMN binding site [chemical binding]; other site 1127744007228 putative substrate binding site [chemical binding]; other site 1127744007229 putative catalytic residue [active] 1127744007230 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1127744007231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744007232 active site 1127744007233 phosphorylation site [posttranslational modification] 1127744007234 intermolecular recognition site; other site 1127744007235 dimerization interface [polypeptide binding]; other site 1127744007236 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1127744007237 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1127744007238 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1127744007239 protein binding site [polypeptide binding]; other site 1127744007240 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1127744007241 DNA repair protein RecN; Region: recN; TIGR00634 1127744007242 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1127744007243 Walker A/P-loop; other site 1127744007244 ATP binding site [chemical binding]; other site 1127744007245 Q-loop/lid; other site 1127744007246 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1127744007247 ABC transporter signature motif; other site 1127744007248 Walker B; other site 1127744007249 D-loop; other site 1127744007250 H-loop/switch region; other site 1127744007251 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1127744007252 arginine repressor; Provisional; Region: PRK04280 1127744007253 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1127744007254 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1127744007255 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127744007256 RNA binding surface [nucleotide binding]; other site 1127744007257 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1127744007258 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1127744007259 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1127744007260 TPP-binding site; other site 1127744007261 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1127744007262 PYR/PP interface [polypeptide binding]; other site 1127744007263 dimer interface [polypeptide binding]; other site 1127744007264 TPP binding site [chemical binding]; other site 1127744007265 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1127744007266 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1127744007267 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1127744007268 substrate binding pocket [chemical binding]; other site 1127744007269 chain length determination region; other site 1127744007270 substrate-Mg2+ binding site; other site 1127744007271 catalytic residues [active] 1127744007272 aspartate-rich region 1; other site 1127744007273 active site lid residues [active] 1127744007274 aspartate-rich region 2; other site 1127744007275 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1127744007276 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1127744007277 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1127744007278 generic binding surface II; other site 1127744007279 generic binding surface I; other site 1127744007280 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1127744007281 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1127744007282 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1127744007283 homodimer interface [polypeptide binding]; other site 1127744007284 NADP binding site [chemical binding]; other site 1127744007285 substrate binding site [chemical binding]; other site 1127744007286 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1127744007287 putative RNA binding site [nucleotide binding]; other site 1127744007288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1127744007289 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1127744007290 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1127744007291 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1127744007292 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1127744007293 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1127744007294 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1127744007295 carboxyltransferase (CT) interaction site; other site 1127744007296 biotinylation site [posttranslational modification]; other site 1127744007297 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1127744007298 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1127744007299 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1127744007300 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1127744007301 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1127744007302 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1127744007303 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1127744007304 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 1127744007305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744007306 Walker A motif; other site 1127744007307 ATP binding site [chemical binding]; other site 1127744007308 Walker B motif; other site 1127744007309 arginine finger; other site 1127744007310 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1127744007311 elongation factor P; Validated; Region: PRK00529 1127744007312 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1127744007313 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1127744007314 RNA binding site [nucleotide binding]; other site 1127744007315 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1127744007316 RNA binding site [nucleotide binding]; other site 1127744007317 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1127744007318 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1127744007319 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1127744007320 active site 1127744007321 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1127744007322 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1127744007323 trimer interface [polypeptide binding]; other site 1127744007324 active site 1127744007325 dimer interface [polypeptide binding]; other site 1127744007326 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1127744007327 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1127744007328 putative sialic acid transporter; Provisional; Region: PRK03893 1127744007329 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1127744007330 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1127744007331 active site 1127744007332 nucleophile elbow; other site 1127744007333 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1127744007334 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1127744007335 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1127744007336 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1127744007337 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1127744007338 active site residue [active] 1127744007339 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1127744007340 tetramer interface [polypeptide binding]; other site 1127744007341 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744007342 catalytic residue [active] 1127744007343 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1127744007344 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1127744007345 tetramer interface [polypeptide binding]; other site 1127744007346 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744007347 catalytic residue [active] 1127744007348 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1127744007349 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1127744007350 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1127744007351 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1127744007352 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127744007353 ATP binding site [chemical binding]; other site 1127744007354 putative Mg++ binding site [ion binding]; other site 1127744007355 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127744007356 nucleotide binding region [chemical binding]; other site 1127744007357 ATP-binding site [chemical binding]; other site 1127744007358 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1127744007359 Anti-repressor SinI; Region: SinI; pfam08671 1127744007360 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127744007361 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127744007362 non-specific DNA binding site [nucleotide binding]; other site 1127744007363 salt bridge; other site 1127744007364 sequence-specific DNA binding site [nucleotide binding]; other site 1127744007365 Anti-repressor SinI; Region: SinI; pfam08671 1127744007366 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1127744007367 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1127744007368 Catalytic site [active] 1127744007369 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1127744007370 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1127744007371 YqzE-like protein; Region: YqzE; pfam14038 1127744007372 ComG operon protein 7; Region: ComGG; pfam14173 1127744007373 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1127744007374 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1127744007375 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1127744007376 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1127744007377 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1127744007378 Type II/IV secretion system protein; Region: T2SE; pfam00437 1127744007379 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1127744007380 Walker A motif; other site 1127744007381 ATP binding site [chemical binding]; other site 1127744007382 Walker B motif; other site 1127744007383 FOG: CBS domain [General function prediction only]; Region: COG0517 1127744007384 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1127744007385 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1127744007386 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1127744007387 Cl binding site [ion binding]; other site 1127744007388 oligomer interface [polypeptide binding]; other site 1127744007389 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1127744007390 Domain of unknown function DUF21; Region: DUF21; pfam01595 1127744007391 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1127744007392 Transporter associated domain; Region: CorC_HlyC; smart01091 1127744007393 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1127744007394 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1127744007395 ArsC family; Region: ArsC; pfam03960 1127744007396 putative catalytic residues [active] 1127744007397 thiol/disulfide switch; other site 1127744007398 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1127744007399 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1127744007400 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1127744007401 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1127744007402 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1127744007403 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1127744007404 putative active site [active] 1127744007405 Zn binding site [ion binding]; other site 1127744007406 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1127744007407 Sulfatase; Region: Sulfatase; pfam00884 1127744007408 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1127744007409 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1127744007410 nucleotide binding site [chemical binding]; other site 1127744007411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1127744007412 Rhomboid family; Region: Rhomboid; pfam01694 1127744007413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744007414 binding surface 1127744007415 TPR motif; other site 1127744007416 TPR repeat; Region: TPR_11; pfam13414 1127744007417 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1127744007418 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1127744007419 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1127744007420 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1127744007421 YceG-like family; Region: YceG; pfam02618 1127744007422 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1127744007423 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1127744007424 Walker A/P-loop; other site 1127744007425 ATP binding site [chemical binding]; other site 1127744007426 Q-loop/lid; other site 1127744007427 ABC transporter signature motif; other site 1127744007428 Walker B; other site 1127744007429 D-loop; other site 1127744007430 H-loop/switch region; other site 1127744007431 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1127744007432 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1127744007433 Walker A/P-loop; other site 1127744007434 ATP binding site [chemical binding]; other site 1127744007435 Q-loop/lid; other site 1127744007436 ABC transporter signature motif; other site 1127744007437 Walker B; other site 1127744007438 D-loop; other site 1127744007439 H-loop/switch region; other site 1127744007440 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1127744007441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744007442 dimer interface [polypeptide binding]; other site 1127744007443 conserved gate region; other site 1127744007444 ABC-ATPase subunit interface; other site 1127744007445 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1127744007446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744007447 dimer interface [polypeptide binding]; other site 1127744007448 conserved gate region; other site 1127744007449 putative PBP binding loops; other site 1127744007450 ABC-ATPase subunit interface; other site 1127744007451 PBP superfamily domain; Region: PBP_like_2; cl17296 1127744007452 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1127744007453 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1127744007454 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1127744007455 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1127744007456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744007457 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744007458 putative substrate translocation pore; other site 1127744007459 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1127744007460 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1127744007461 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1127744007462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1127744007463 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1127744007464 Lysin motif; Region: LysM; smart00257 1127744007465 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1127744007466 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1127744007467 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1127744007468 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1127744007469 ferric uptake regulator; Provisional; Region: fur; PRK09462 1127744007470 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1127744007471 metal binding site 2 [ion binding]; metal-binding site 1127744007472 putative DNA binding helix; other site 1127744007473 metal binding site 1 [ion binding]; metal-binding site 1127744007474 dimer interface [polypeptide binding]; other site 1127744007475 structural Zn2+ binding site [ion binding]; other site 1127744007476 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1127744007477 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127744007478 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1127744007479 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1127744007480 endonuclease IV; Provisional; Region: PRK01060 1127744007481 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1127744007482 AP (apurinic/apyrimidinic) site pocket; other site 1127744007483 DNA interaction; other site 1127744007484 Metal-binding active site; metal-binding site 1127744007485 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1127744007486 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1127744007487 ATP binding site [chemical binding]; other site 1127744007488 Mg++ binding site [ion binding]; other site 1127744007489 motif III; other site 1127744007490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127744007491 nucleotide binding region [chemical binding]; other site 1127744007492 ATP-binding site [chemical binding]; other site 1127744007493 YqfQ-like protein; Region: YqfQ; pfam14181 1127744007494 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1127744007495 LytB protein; Region: LYTB; pfam02401 1127744007496 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1127744007497 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1127744007498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1127744007499 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1127744007500 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1127744007501 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1127744007502 Family of unknown function (DUF633); Region: DUF633; pfam04816 1127744007503 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1127744007504 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1127744007505 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1127744007506 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1127744007507 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1127744007508 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744007509 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1127744007510 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744007511 DNA binding residues [nucleotide binding] 1127744007512 DNA primase; Validated; Region: dnaG; PRK05667 1127744007513 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1127744007514 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1127744007515 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1127744007516 active site 1127744007517 metal binding site [ion binding]; metal-binding site 1127744007518 interdomain interaction site; other site 1127744007519 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1127744007520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1127744007521 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1127744007522 HTH domain; Region: HTH_11; pfam08279 1127744007523 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1127744007524 FOG: CBS domain [General function prediction only]; Region: COG0517 1127744007525 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 1127744007526 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1127744007527 dimer interface [polypeptide binding]; other site 1127744007528 motif 1; other site 1127744007529 active site 1127744007530 motif 2; other site 1127744007531 motif 3; other site 1127744007532 Recombination protein O N terminal; Region: RecO_N; pfam11967 1127744007533 DNA repair protein RecO; Region: reco; TIGR00613 1127744007534 Recombination protein O C terminal; Region: RecO_C; pfam02565 1127744007535 YqzL-like protein; Region: YqzL; pfam14006 1127744007536 GTPase Era; Reviewed; Region: era; PRK00089 1127744007537 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1127744007538 G1 box; other site 1127744007539 GTP/Mg2+ binding site [chemical binding]; other site 1127744007540 Switch I region; other site 1127744007541 G2 box; other site 1127744007542 Switch II region; other site 1127744007543 G3 box; other site 1127744007544 G4 box; other site 1127744007545 G5 box; other site 1127744007546 KH domain; Region: KH_2; pfam07650 1127744007547 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1127744007548 active site 1127744007549 catalytic motif [active] 1127744007550 Zn binding site [ion binding]; other site 1127744007551 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1127744007552 metal-binding heat shock protein; Provisional; Region: PRK00016 1127744007553 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1127744007554 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1127744007555 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1127744007556 Zn2+ binding site [ion binding]; other site 1127744007557 Mg2+ binding site [ion binding]; other site 1127744007558 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1127744007559 PhoH-like protein; Region: PhoH; pfam02562 1127744007560 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1127744007561 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1127744007562 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1127744007563 hypothetical protein; Provisional; Region: PRK13665 1127744007564 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1127744007565 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1127744007566 dimer interface [polypeptide binding]; other site 1127744007567 active site residues [active] 1127744007568 Yqey-like protein; Region: YqeY; pfam09424 1127744007569 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1127744007570 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1127744007571 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1127744007572 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1127744007573 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1127744007574 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1127744007575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127744007576 FeS/SAM binding site; other site 1127744007577 TRAM domain; Region: TRAM; cl01282 1127744007578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1127744007579 RNA methyltransferase, RsmE family; Region: TIGR00046 1127744007580 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1127744007581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744007582 S-adenosylmethionine binding site [chemical binding]; other site 1127744007583 chaperone protein DnaJ; Provisional; Region: PRK14280 1127744007584 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1127744007585 HSP70 interaction site [polypeptide binding]; other site 1127744007586 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1127744007587 substrate binding site [polypeptide binding]; other site 1127744007588 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1127744007589 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1127744007590 dimer interface [polypeptide binding]; other site 1127744007591 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1127744007592 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1127744007593 nucleotide binding site [chemical binding]; other site 1127744007594 NEF interaction site [polypeptide binding]; other site 1127744007595 SBD interface [polypeptide binding]; other site 1127744007596 GrpE; Region: GrpE; pfam01025 1127744007597 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1127744007598 dimer interface [polypeptide binding]; other site 1127744007599 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1127744007600 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1127744007601 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1127744007602 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1127744007603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127744007604 FeS/SAM binding site; other site 1127744007605 HemN C-terminal domain; Region: HemN_C; pfam06969 1127744007606 GTP-binding protein LepA; Provisional; Region: PRK05433 1127744007607 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1127744007608 G1 box; other site 1127744007609 putative GEF interaction site [polypeptide binding]; other site 1127744007610 GTP/Mg2+ binding site [chemical binding]; other site 1127744007611 Switch I region; other site 1127744007612 G2 box; other site 1127744007613 G3 box; other site 1127744007614 Switch II region; other site 1127744007615 G4 box; other site 1127744007616 G5 box; other site 1127744007617 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1127744007618 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1127744007619 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1127744007620 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1127744007621 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1127744007622 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1127744007623 germination protease; Provisional; Region: PRK02858 1127744007624 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1127744007625 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1127744007626 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1127744007627 YqzM-like protein; Region: YqzM; pfam14141 1127744007628 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1127744007629 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1127744007630 Competence protein; Region: Competence; pfam03772 1127744007631 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1127744007632 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1127744007633 catalytic motif [active] 1127744007634 Zn binding site [ion binding]; other site 1127744007635 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 1127744007636 SLBB domain; Region: SLBB; pfam10531 1127744007637 Helix-hairpin-helix motif; Region: HHH; pfam00633 1127744007638 late competence protein ComER; Validated; Region: PRK07680 1127744007639 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1127744007640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744007641 S-adenosylmethionine binding site [chemical binding]; other site 1127744007642 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1127744007643 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1127744007644 Zn2+ binding site [ion binding]; other site 1127744007645 Mg2+ binding site [ion binding]; other site 1127744007646 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1127744007647 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1127744007648 active site 1127744007649 (T/H)XGH motif; other site 1127744007650 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 1127744007651 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 1127744007652 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1127744007653 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1127744007654 shikimate binding site; other site 1127744007655 NAD(P) binding site [chemical binding]; other site 1127744007656 GTPase YqeH; Provisional; Region: PRK13796 1127744007657 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1127744007658 GTP/Mg2+ binding site [chemical binding]; other site 1127744007659 G4 box; other site 1127744007660 G5 box; other site 1127744007661 G1 box; other site 1127744007662 Switch I region; other site 1127744007663 G2 box; other site 1127744007664 G3 box; other site 1127744007665 Switch II region; other site 1127744007666 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1127744007667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744007668 active site 1127744007669 motif I; other site 1127744007670 motif II; other site 1127744007671 Sporulation inhibitor A; Region: Sda; pfam08970 1127744007672 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 1127744007673 active site 1127744007674 catalytic triad [active] 1127744007675 oxyanion hole [active] 1127744007676 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1127744007677 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1127744007678 arginine decarboxylase; Provisional; Region: PRK15029 1127744007679 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1127744007680 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1127744007681 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744007682 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744007683 DNA binding residues [nucleotide binding] 1127744007684 AIPR protein; Region: AIPR; pfam10592 1127744007685 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127744007686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127744007687 non-specific DNA binding site [nucleotide binding]; other site 1127744007688 salt bridge; other site 1127744007689 sequence-specific DNA binding site [nucleotide binding]; other site 1127744007690 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744007691 DNA binding residues [nucleotide binding] 1127744007692 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744007693 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744007694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744007695 TPR motif; other site 1127744007696 binding surface 1127744007697 TPR repeat; Region: TPR_11; pfam13414 1127744007698 anthocyanidin reductase; Provisional; Region: PLN00198 1127744007699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127744007700 NAD(P) binding site [chemical binding]; other site 1127744007701 active site 1127744007702 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1127744007703 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1127744007704 ligand binding site [chemical binding]; other site 1127744007705 flexible hinge region; other site 1127744007706 LXG domain of WXG superfamily; Region: LXG; pfam04740 1127744007707 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1127744007708 RNAase interaction site [polypeptide binding]; other site 1127744007709 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1127744007710 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1127744007711 Predicted transcriptional regulators [Transcription]; Region: COG1695 1127744007712 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1127744007713 hypothetical protein; Validated; Region: PRK06217 1127744007714 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1127744007715 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1127744007716 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1127744007717 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1127744007718 CPxP motif; other site 1127744007719 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1127744007720 active site residue [active] 1127744007721 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1127744007722 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1127744007723 CPxP motif; other site 1127744007724 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1127744007725 active site residue [active] 1127744007726 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1127744007727 active site residue [active] 1127744007728 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1127744007729 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1127744007730 putative homodimer interface [polypeptide binding]; other site 1127744007731 putative homotetramer interface [polypeptide binding]; other site 1127744007732 putative metal binding site [ion binding]; other site 1127744007733 putative homodimer-homodimer interface [polypeptide binding]; other site 1127744007734 putative allosteric switch controlling residues; other site 1127744007735 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1127744007736 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1127744007737 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1127744007738 DNA binding residues [nucleotide binding] 1127744007739 dimer interface [polypeptide binding]; other site 1127744007740 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1127744007741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744007742 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744007743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744007744 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1127744007745 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1127744007746 Coenzyme A binding pocket [chemical binding]; other site 1127744007747 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1127744007748 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1127744007749 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1127744007750 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1127744007751 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1127744007752 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1127744007753 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1127744007754 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1127744007755 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1127744007756 Ligand binding site; other site 1127744007757 metal-binding site 1127744007758 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1127744007759 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1127744007760 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1127744007761 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1127744007762 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1127744007763 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1127744007764 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1127744007765 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1127744007766 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1127744007767 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1127744007768 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1127744007769 Isochorismatase family; Region: Isochorismatase; pfam00857 1127744007770 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1127744007771 catalytic triad [active] 1127744007772 conserved cis-peptide bond; other site 1127744007773 DinB family; Region: DinB; pfam05163 1127744007774 DinB superfamily; Region: DinB_2; pfam12867 1127744007775 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1127744007776 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744007777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744007778 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1127744007779 putative dimerization interface [polypeptide binding]; other site 1127744007780 Nitronate monooxygenase; Region: NMO; pfam03060 1127744007781 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1127744007782 FMN binding site [chemical binding]; other site 1127744007783 substrate binding site [chemical binding]; other site 1127744007784 putative catalytic residue [active] 1127744007785 glutamate racemase; Region: glut_race; TIGR00067 1127744007786 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1127744007787 putative binding site; other site 1127744007788 putative dimer interface [polypeptide binding]; other site 1127744007789 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1127744007790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744007791 DNA-binding site [nucleotide binding]; DNA binding site 1127744007792 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1127744007793 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1127744007794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744007795 D-galactonate transporter; Region: 2A0114; TIGR00893 1127744007796 putative substrate translocation pore; other site 1127744007797 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1127744007798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127744007799 NAD(P) binding site [chemical binding]; other site 1127744007800 active site 1127744007801 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1127744007802 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1127744007803 PYR/PP interface [polypeptide binding]; other site 1127744007804 dimer interface [polypeptide binding]; other site 1127744007805 TPP binding site [chemical binding]; other site 1127744007806 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1127744007807 transketolase; Reviewed; Region: PRK05899 1127744007808 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1127744007809 TPP-binding site [chemical binding]; other site 1127744007810 dimer interface [polypeptide binding]; other site 1127744007811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744007812 putative substrate translocation pore; other site 1127744007813 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744007814 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744007815 MarR family; Region: MarR_2; cl17246 1127744007816 YodA lipocalin-like domain; Region: YodA; pfam09223 1127744007817 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1127744007818 chitosan binding site [chemical binding]; other site 1127744007819 catalytic residues [active] 1127744007820 Mor transcription activator family; Region: Mor; cl02360 1127744007821 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1127744007822 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1127744007823 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1127744007824 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1127744007825 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1127744007826 Bacterial SH3 domain; Region: SH3_3; cl17532 1127744007827 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127744007828 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1127744007829 active site 1127744007830 metal binding site [ion binding]; metal-binding site 1127744007831 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1127744007832 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1127744007833 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1127744007834 NAD binding site [chemical binding]; other site 1127744007835 catalytic Zn binding site [ion binding]; other site 1127744007836 structural Zn binding site [ion binding]; other site 1127744007837 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1127744007838 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1127744007839 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1127744007840 substrate binding [chemical binding]; other site 1127744007841 active site 1127744007842 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1127744007843 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1127744007844 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 1127744007845 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1127744007846 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1127744007847 active site 1127744007848 phosphorylation site [posttranslational modification] 1127744007849 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1127744007850 active pocket/dimerization site; other site 1127744007851 active site 1127744007852 phosphorylation site [posttranslational modification] 1127744007853 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1127744007854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744007855 Walker A motif; other site 1127744007856 ATP binding site [chemical binding]; other site 1127744007857 Walker B motif; other site 1127744007858 arginine finger; other site 1127744007859 Transcriptional antiterminator [Transcription]; Region: COG3933 1127744007860 PRD domain; Region: PRD; pfam00874 1127744007861 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1127744007862 active pocket/dimerization site; other site 1127744007863 active site 1127744007864 phosphorylation site [posttranslational modification] 1127744007865 PRD domain; Region: PRD; pfam00874 1127744007866 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1127744007867 LysE type translocator; Region: LysE; cl00565 1127744007868 Predicted transcriptional regulators [Transcription]; Region: COG1378 1127744007869 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1127744007870 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1127744007871 C-terminal domain interface [polypeptide binding]; other site 1127744007872 sugar binding site [chemical binding]; other site 1127744007873 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1127744007874 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744007875 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744007876 DNA binding residues [nucleotide binding] 1127744007877 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1127744007878 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1127744007879 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1127744007880 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1127744007881 catalytic triad [active] 1127744007882 catalytic triad [active] 1127744007883 oxyanion hole [active] 1127744007884 YrhK-like protein; Region: YrhK; pfam14145 1127744007885 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1127744007886 Cytochrome P450; Region: p450; pfam00067 1127744007887 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1127744007888 Flavodoxin; Region: Flavodoxin_1; pfam00258 1127744007889 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1127744007890 FAD binding pocket [chemical binding]; other site 1127744007891 FAD binding motif [chemical binding]; other site 1127744007892 catalytic residues [active] 1127744007893 NAD binding pocket [chemical binding]; other site 1127744007894 phosphate binding motif [ion binding]; other site 1127744007895 beta-alpha-beta structure motif; other site 1127744007896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744007897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744007898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744007899 S-adenosylmethionine binding site [chemical binding]; other site 1127744007900 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 1127744007901 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1127744007902 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1127744007903 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1127744007904 YrhC-like protein; Region: YrhC; pfam14143 1127744007905 cystathionine beta-lyase; Provisional; Region: PRK07671 1127744007906 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1127744007907 homodimer interface [polypeptide binding]; other site 1127744007908 substrate-cofactor binding pocket; other site 1127744007909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744007910 catalytic residue [active] 1127744007911 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1127744007912 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1127744007913 dimer interface [polypeptide binding]; other site 1127744007914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744007915 catalytic residue [active] 1127744007916 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1127744007917 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1127744007918 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1127744007919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744007920 S-adenosylmethionine binding site [chemical binding]; other site 1127744007921 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1127744007922 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1127744007923 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1127744007924 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1127744007925 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1127744007926 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1127744007927 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1127744007928 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1127744007929 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1127744007930 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1127744007931 ATP-binding site [chemical binding]; other site 1127744007932 Sugar specificity; other site 1127744007933 Pyrimidine base specificity; other site 1127744007934 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1127744007935 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1127744007936 Peptidase family U32; Region: Peptidase_U32; pfam01136 1127744007937 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1127744007938 Peptidase family U32; Region: Peptidase_U32; pfam01136 1127744007939 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1127744007940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744007941 S-adenosylmethionine binding site [chemical binding]; other site 1127744007942 conserved hypothetical protein, YceG family; Region: TIGR00247 1127744007943 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1127744007944 dimerization interface [polypeptide binding]; other site 1127744007945 hypothetical protein; Provisional; Region: PRK13678 1127744007946 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 1127744007947 hypothetical protein; Provisional; Region: PRK05473 1127744007948 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1127744007949 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1127744007950 motif 1; other site 1127744007951 active site 1127744007952 motif 2; other site 1127744007953 motif 3; other site 1127744007954 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1127744007955 DHHA1 domain; Region: DHHA1; pfam02272 1127744007956 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1127744007957 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1127744007958 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 1127744007959 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1127744007960 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1127744007961 AAA domain; Region: AAA_30; pfam13604 1127744007962 Family description; Region: UvrD_C_2; pfam13538 1127744007963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744007964 binding surface 1127744007965 TPR motif; other site 1127744007966 TPR repeat; Region: TPR_11; pfam13414 1127744007967 TPR repeat; Region: TPR_11; pfam13414 1127744007968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744007969 binding surface 1127744007970 TPR motif; other site 1127744007971 TPR repeat; Region: TPR_11; pfam13414 1127744007972 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1127744007973 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1127744007974 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1127744007975 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1127744007976 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127744007977 catalytic residue [active] 1127744007978 Predicted transcriptional regulator [Transcription]; Region: COG1959 1127744007979 Transcriptional regulator; Region: Rrf2; pfam02082 1127744007980 recombination factor protein RarA; Reviewed; Region: PRK13342 1127744007981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744007982 Walker A motif; other site 1127744007983 ATP binding site [chemical binding]; other site 1127744007984 Walker B motif; other site 1127744007985 arginine finger; other site 1127744007986 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1127744007987 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1127744007988 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1127744007989 putative ATP binding site [chemical binding]; other site 1127744007990 putative substrate interface [chemical binding]; other site 1127744007991 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1127744007992 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1127744007993 dimer interface [polypeptide binding]; other site 1127744007994 anticodon binding site; other site 1127744007995 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1127744007996 homodimer interface [polypeptide binding]; other site 1127744007997 motif 1; other site 1127744007998 active site 1127744007999 motif 2; other site 1127744008000 GAD domain; Region: GAD; pfam02938 1127744008001 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1127744008002 motif 3; other site 1127744008003 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1127744008004 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1127744008005 dimer interface [polypeptide binding]; other site 1127744008006 motif 1; other site 1127744008007 active site 1127744008008 motif 2; other site 1127744008009 motif 3; other site 1127744008010 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1127744008011 anticodon binding site; other site 1127744008012 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1127744008013 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1127744008014 Bacterial SH3 domain; Region: SH3_3; pfam08239 1127744008015 Bacterial SH3 domain; Region: SH3_3; pfam08239 1127744008016 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1127744008017 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1127744008018 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1127744008019 active site 1127744008020 metal binding site [ion binding]; metal-binding site 1127744008021 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1127744008022 putative active site [active] 1127744008023 dimerization interface [polypeptide binding]; other site 1127744008024 putative tRNAtyr binding site [nucleotide binding]; other site 1127744008025 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1127744008026 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1127744008027 Zn2+ binding site [ion binding]; other site 1127744008028 Mg2+ binding site [ion binding]; other site 1127744008029 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1127744008030 synthetase active site [active] 1127744008031 NTP binding site [chemical binding]; other site 1127744008032 metal binding site [ion binding]; metal-binding site 1127744008033 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1127744008034 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1127744008035 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127744008036 active site 1127744008037 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1127744008038 DHH family; Region: DHH; pfam01368 1127744008039 DHHA1 domain; Region: DHHA1; pfam02272 1127744008040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1127744008041 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1127744008042 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1127744008043 TrkA-C domain; Region: TrkA_C; pfam02080 1127744008044 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1127744008045 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1127744008046 RDD family; Region: RDD; pfam06271 1127744008047 Protein export membrane protein; Region: SecD_SecF; pfam02355 1127744008048 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1127744008049 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1127744008050 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1127744008051 Predicted membrane protein [Function unknown]; Region: COG2323 1127744008052 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1127744008053 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1127744008054 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1127744008055 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1127744008056 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1127744008057 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1127744008058 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1127744008059 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1127744008060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744008061 Walker A motif; other site 1127744008062 ATP binding site [chemical binding]; other site 1127744008063 Walker B motif; other site 1127744008064 arginine finger; other site 1127744008065 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1127744008066 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1127744008067 RuvA N terminal domain; Region: RuvA_N; pfam01330 1127744008068 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1127744008069 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1127744008070 BofC C-terminal domain; Region: BofC_C; pfam08955 1127744008071 polyol permease family; Region: 2A0118; TIGR00897 1127744008072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744008073 putative substrate translocation pore; other site 1127744008074 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1127744008075 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1127744008076 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1127744008077 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1127744008078 active site 1127744008079 substrate binding site [chemical binding]; other site 1127744008080 ATP binding site [chemical binding]; other site 1127744008081 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1127744008082 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1127744008083 hypothetical protein; Validated; Region: PRK00110 1127744008084 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1127744008085 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744008086 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1127744008087 quinolinate synthetase; Provisional; Region: PRK09375 1127744008088 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1127744008089 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1127744008090 dimerization interface [polypeptide binding]; other site 1127744008091 active site 1127744008092 L-aspartate oxidase; Provisional; Region: PRK08071 1127744008093 L-aspartate oxidase; Provisional; Region: PRK06175 1127744008094 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1127744008095 cysteine desulfurase; Provisional; Region: PRK02948 1127744008096 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1127744008097 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127744008098 catalytic residue [active] 1127744008099 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1127744008100 HTH domain; Region: HTH_11; pfam08279 1127744008101 3H domain; Region: 3H; pfam02829 1127744008102 prephenate dehydratase; Provisional; Region: PRK11898 1127744008103 Prephenate dehydratase; Region: PDT; pfam00800 1127744008104 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1127744008105 putative L-Phe binding site [chemical binding]; other site 1127744008106 hypothetical protein; Provisional; Region: PRK04435 1127744008107 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1127744008108 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1127744008109 GTP1/OBG; Region: GTP1_OBG; pfam01018 1127744008110 Obg GTPase; Region: Obg; cd01898 1127744008111 G1 box; other site 1127744008112 GTP/Mg2+ binding site [chemical binding]; other site 1127744008113 Switch I region; other site 1127744008114 G2 box; other site 1127744008115 G3 box; other site 1127744008116 Switch II region; other site 1127744008117 G4 box; other site 1127744008118 G5 box; other site 1127744008119 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1127744008120 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1127744008121 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1127744008122 hypothetical protein; Provisional; Region: PRK14553 1127744008123 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1127744008124 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1127744008125 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1127744008126 active site 1127744008127 Peptidase family M50; Region: Peptidase_M50; pfam02163 1127744008128 putative substrate binding region [chemical binding]; other site 1127744008129 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1127744008130 Peptidase family M23; Region: Peptidase_M23; pfam01551 1127744008131 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1127744008132 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1127744008133 Switch I; other site 1127744008134 Switch II; other site 1127744008135 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1127744008136 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1127744008137 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1127744008138 rod shape-determining protein MreC; Region: mreC; TIGR00219 1127744008139 rod shape-determining protein MreC; Region: MreC; pfam04085 1127744008140 rod shape-determining protein MreB; Provisional; Region: PRK13927 1127744008141 MreB and similar proteins; Region: MreB_like; cd10225 1127744008142 nucleotide binding site [chemical binding]; other site 1127744008143 Mg binding site [ion binding]; other site 1127744008144 putative protofilament interaction site [polypeptide binding]; other site 1127744008145 RodZ interaction site [polypeptide binding]; other site 1127744008146 hypothetical protein; Reviewed; Region: PRK00024 1127744008147 Helix-hairpin-helix motif; Region: HHH; pfam00633 1127744008148 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1127744008149 MPN+ (JAMM) motif; other site 1127744008150 Zinc-binding site [ion binding]; other site 1127744008151 Maf-like protein; Region: Maf; pfam02545 1127744008152 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1127744008153 active site 1127744008154 dimer interface [polypeptide binding]; other site 1127744008155 Sporulation related domain; Region: SPOR; pfam05036 1127744008156 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1127744008157 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1127744008158 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1127744008159 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1127744008160 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1127744008161 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1127744008162 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1127744008163 active site 1127744008164 HIGH motif; other site 1127744008165 nucleotide binding site [chemical binding]; other site 1127744008166 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1127744008167 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1127744008168 active site 1127744008169 KMSKS motif; other site 1127744008170 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1127744008171 tRNA binding surface [nucleotide binding]; other site 1127744008172 anticodon binding site; other site 1127744008173 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1127744008174 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1127744008175 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1127744008176 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1127744008177 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127744008178 inhibitor-cofactor binding pocket; inhibition site 1127744008179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744008180 catalytic residue [active] 1127744008181 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1127744008182 dimer interface [polypeptide binding]; other site 1127744008183 active site 1127744008184 Schiff base residues; other site 1127744008185 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1127744008186 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1127744008187 active site 1127744008188 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1127744008189 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1127744008190 domain interfaces; other site 1127744008191 active site 1127744008192 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 1127744008193 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1127744008194 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1127744008195 tRNA; other site 1127744008196 putative tRNA binding site [nucleotide binding]; other site 1127744008197 putative NADP binding site [chemical binding]; other site 1127744008198 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1127744008199 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1127744008200 G1 box; other site 1127744008201 GTP/Mg2+ binding site [chemical binding]; other site 1127744008202 Switch I region; other site 1127744008203 G2 box; other site 1127744008204 G3 box; other site 1127744008205 Switch II region; other site 1127744008206 G4 box; other site 1127744008207 G5 box; other site 1127744008208 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1127744008209 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1127744008210 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1127744008211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744008212 Walker A motif; other site 1127744008213 ATP binding site [chemical binding]; other site 1127744008214 Walker B motif; other site 1127744008215 arginine finger; other site 1127744008216 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1127744008217 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1127744008218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744008219 Walker A motif; other site 1127744008220 ATP binding site [chemical binding]; other site 1127744008221 Walker B motif; other site 1127744008222 arginine finger; other site 1127744008223 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1127744008224 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1127744008225 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1127744008226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744008227 Walker A motif; other site 1127744008228 ATP binding site [chemical binding]; other site 1127744008229 Walker B motif; other site 1127744008230 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1127744008231 trigger factor; Provisional; Region: tig; PRK01490 1127744008232 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1127744008233 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1127744008234 TPR repeat; Region: TPR_11; pfam13414 1127744008235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744008236 binding surface 1127744008237 TPR motif; other site 1127744008238 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1127744008239 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1127744008240 hypothetical protein; Provisional; Region: PRK14812 1127744008241 substrate binding site [chemical binding]; other site 1127744008242 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1127744008243 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1127744008244 substrate binding site [chemical binding]; other site 1127744008245 ligand binding site [chemical binding]; other site 1127744008246 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1127744008247 tartrate dehydrogenase; Region: TTC; TIGR02089 1127744008248 2-isopropylmalate synthase; Validated; Region: PRK00915 1127744008249 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1127744008250 active site 1127744008251 metal binding site [ion binding]; metal-binding site 1127744008252 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1127744008253 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1127744008254 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1127744008255 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1127744008256 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1127744008257 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1127744008258 putative valine binding site [chemical binding]; other site 1127744008259 dimer interface [polypeptide binding]; other site 1127744008260 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1127744008261 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1127744008262 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1127744008263 PYR/PP interface [polypeptide binding]; other site 1127744008264 dimer interface [polypeptide binding]; other site 1127744008265 TPP binding site [chemical binding]; other site 1127744008266 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1127744008267 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1127744008268 TPP-binding site [chemical binding]; other site 1127744008269 dimer interface [polypeptide binding]; other site 1127744008270 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1127744008271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744008272 Coenzyme A binding pocket [chemical binding]; other site 1127744008273 Heat induced stress protein YflT; Region: YflT; pfam11181 1127744008274 conserved domain; Region: TIGR02271 1127744008275 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1127744008276 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1127744008277 active site 1127744008278 metal binding site [ion binding]; metal-binding site 1127744008279 homotetramer interface [polypeptide binding]; other site 1127744008280 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1127744008281 active site 1127744008282 dimerization interface [polypeptide binding]; other site 1127744008283 ribonuclease PH; Reviewed; Region: rph; PRK00173 1127744008284 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1127744008285 hexamer interface [polypeptide binding]; other site 1127744008286 active site 1127744008287 Spore germination protein [General function prediction only]; Region: COG5401 1127744008288 Sporulation and spore germination; Region: Germane; pfam10646 1127744008289 Sporulation and spore germination; Region: Germane; pfam10646 1127744008290 glutamate racemase; Region: glut_race; TIGR00067 1127744008291 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744008292 MarR family; Region: MarR; pfam01047 1127744008293 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127744008294 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127744008295 DNA binding residues [nucleotide binding] 1127744008296 dimerization interface [polypeptide binding]; other site 1127744008297 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1127744008298 active site 1127744008299 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1127744008300 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1127744008301 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1127744008302 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1127744008303 L-aspartate oxidase; Provisional; Region: PRK06175 1127744008304 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1127744008305 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1127744008306 putative Iron-sulfur protein interface [polypeptide binding]; other site 1127744008307 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1127744008308 proximal heme binding site [chemical binding]; other site 1127744008309 distal heme binding site [chemical binding]; other site 1127744008310 putative dimer interface [polypeptide binding]; other site 1127744008311 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1127744008312 aspartate kinase; Reviewed; Region: PRK06635 1127744008313 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1127744008314 putative nucleotide binding site [chemical binding]; other site 1127744008315 putative catalytic residues [active] 1127744008316 putative Mg ion binding site [ion binding]; other site 1127744008317 putative aspartate binding site [chemical binding]; other site 1127744008318 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1127744008319 putative allosteric regulatory site; other site 1127744008320 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1127744008321 putative allosteric regulatory residue; other site 1127744008322 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1127744008323 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1127744008324 GIY-YIG motif/motif A; other site 1127744008325 active site 1127744008326 catalytic site [active] 1127744008327 putative DNA binding site [nucleotide binding]; other site 1127744008328 metal binding site [ion binding]; metal-binding site 1127744008329 UvrB/uvrC motif; Region: UVR; pfam02151 1127744008330 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1127744008331 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1127744008332 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1127744008333 catalytic residues [active] 1127744008334 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1127744008335 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1127744008336 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1127744008337 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1127744008338 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1127744008339 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1127744008340 Ligand binding site [chemical binding]; other site 1127744008341 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1127744008342 enoyl-CoA hydratase; Provisional; Region: PRK07658 1127744008343 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127744008344 substrate binding site [chemical binding]; other site 1127744008345 oxyanion hole (OAH) forming residues; other site 1127744008346 trimer interface [polypeptide binding]; other site 1127744008347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744008348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744008349 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1127744008350 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1127744008351 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1127744008352 acyl-activating enzyme (AAE) consensus motif; other site 1127744008353 putative AMP binding site [chemical binding]; other site 1127744008354 putative active site [active] 1127744008355 putative CoA binding site [chemical binding]; other site 1127744008356 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1127744008357 MutS domain III; Region: MutS_III; pfam05192 1127744008358 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1127744008359 Walker A/P-loop; other site 1127744008360 ATP binding site [chemical binding]; other site 1127744008361 Q-loop/lid; other site 1127744008362 ABC transporter signature motif; other site 1127744008363 Walker B; other site 1127744008364 D-loop; other site 1127744008365 H-loop/switch region; other site 1127744008366 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1127744008367 Smr domain; Region: Smr; pfam01713 1127744008368 hypothetical protein; Provisional; Region: PRK08609 1127744008369 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1127744008370 active site 1127744008371 primer binding site [nucleotide binding]; other site 1127744008372 NTP binding site [chemical binding]; other site 1127744008373 metal binding triad [ion binding]; metal-binding site 1127744008374 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1127744008375 active site 1127744008376 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1127744008377 Colicin V production protein; Region: Colicin_V; pfam02674 1127744008378 cell division protein ZapA; Provisional; Region: PRK14126 1127744008379 ribonuclease HIII; Provisional; Region: PRK00996 1127744008380 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1127744008381 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1127744008382 RNA/DNA hybrid binding site [nucleotide binding]; other site 1127744008383 active site 1127744008384 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1127744008385 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1127744008386 putative tRNA-binding site [nucleotide binding]; other site 1127744008387 B3/4 domain; Region: B3_4; pfam03483 1127744008388 tRNA synthetase B5 domain; Region: B5; smart00874 1127744008389 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1127744008390 dimer interface [polypeptide binding]; other site 1127744008391 motif 1; other site 1127744008392 motif 3; other site 1127744008393 motif 2; other site 1127744008394 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1127744008395 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1127744008396 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1127744008397 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1127744008398 dimer interface [polypeptide binding]; other site 1127744008399 motif 1; other site 1127744008400 active site 1127744008401 motif 2; other site 1127744008402 motif 3; other site 1127744008403 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1127744008404 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1127744008405 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1127744008406 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1127744008407 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1127744008408 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1127744008409 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1127744008410 FAD binding domain; Region: FAD_binding_4; pfam01565 1127744008411 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1127744008412 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1127744008413 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1127744008414 Cysteine-rich domain; Region: CCG; pfam02754 1127744008415 Cysteine-rich domain; Region: CCG; pfam02754 1127744008416 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1127744008417 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127744008418 active site 1127744008419 metal binding site [ion binding]; metal-binding site 1127744008420 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1127744008421 Carbon starvation protein CstA; Region: CstA; pfam02554 1127744008422 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1127744008423 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1127744008424 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1127744008425 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1127744008426 Predicted transcriptional regulators [Transcription]; Region: COG1695 1127744008427 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1127744008428 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1127744008429 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1127744008430 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1127744008431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744008432 putative PBP binding loops; other site 1127744008433 dimer interface [polypeptide binding]; other site 1127744008434 ABC-ATPase subunit interface; other site 1127744008435 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1127744008436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744008437 dimer interface [polypeptide binding]; other site 1127744008438 conserved gate region; other site 1127744008439 putative PBP binding loops; other site 1127744008440 ABC-ATPase subunit interface; other site 1127744008441 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1127744008442 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1127744008443 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1127744008444 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1127744008445 active site 1127744008446 metal binding site [ion binding]; metal-binding site 1127744008447 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1127744008448 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744008449 active site 1127744008450 motif I; other site 1127744008451 motif II; other site 1127744008452 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744008453 motif II; other site 1127744008454 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1127744008455 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1127744008456 intersubunit interface [polypeptide binding]; other site 1127744008457 active site 1127744008458 Zn2+ binding site [ion binding]; other site 1127744008459 L-ribulokinase; Region: L-ribulokinase; TIGR01234 1127744008460 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1127744008461 N- and C-terminal domain interface [polypeptide binding]; other site 1127744008462 active site 1127744008463 MgATP binding site [chemical binding]; other site 1127744008464 catalytic site [active] 1127744008465 metal binding site [ion binding]; metal-binding site 1127744008466 carbohydrate binding site [chemical binding]; other site 1127744008467 homodimer interface [polypeptide binding]; other site 1127744008468 L-arabinose isomerase; Provisional; Region: PRK02929 1127744008469 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1127744008470 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1127744008471 trimer interface [polypeptide binding]; other site 1127744008472 putative substrate binding site [chemical binding]; other site 1127744008473 putative metal binding site [ion binding]; other site 1127744008474 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1127744008475 substrate binding site [chemical binding]; other site 1127744008476 active site 1127744008477 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1127744008478 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1127744008479 oligomer interface [polypeptide binding]; other site 1127744008480 active site 1127744008481 metal binding site [ion binding]; metal-binding site 1127744008482 Predicted membrane protein [Function unknown]; Region: COG3326 1127744008483 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1127744008484 23S rRNA binding site [nucleotide binding]; other site 1127744008485 L21 binding site [polypeptide binding]; other site 1127744008486 L13 binding site [polypeptide binding]; other site 1127744008487 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1127744008488 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1127744008489 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1127744008490 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1127744008491 antiholin-like protein LrgB; Provisional; Region: PRK04288 1127744008492 LrgA family; Region: LrgA; cl00608 1127744008493 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1127744008494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744008495 active site 1127744008496 phosphorylation site [posttranslational modification] 1127744008497 intermolecular recognition site; other site 1127744008498 dimerization interface [polypeptide binding]; other site 1127744008499 LytTr DNA-binding domain; Region: LytTR; smart00850 1127744008500 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1127744008501 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1127744008502 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1127744008503 Histidine kinase; Region: His_kinase; pfam06580 1127744008504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744008505 ATP binding site [chemical binding]; other site 1127744008506 Mg2+ binding site [ion binding]; other site 1127744008507 G-X-G motif; other site 1127744008508 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1127744008509 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744008510 motif II; other site 1127744008511 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1127744008512 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1127744008513 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1127744008514 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1127744008515 active site 1127744008516 dimer interface [polypeptide binding]; other site 1127744008517 motif 1; other site 1127744008518 motif 2; other site 1127744008519 motif 3; other site 1127744008520 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1127744008521 anticodon binding site; other site 1127744008522 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 1127744008523 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1127744008524 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1127744008525 primosomal protein DnaI; Reviewed; Region: PRK08939 1127744008526 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1127744008527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744008528 Walker A motif; other site 1127744008529 ATP binding site [chemical binding]; other site 1127744008530 Walker B motif; other site 1127744008531 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1127744008532 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1127744008533 ATP cone domain; Region: ATP-cone; pfam03477 1127744008534 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1127744008535 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1127744008536 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1127744008537 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1127744008538 Predicted transcriptional regulators [Transcription]; Region: COG1733 1127744008539 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1127744008540 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1127744008541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744008542 putative substrate translocation pore; other site 1127744008543 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1127744008544 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1127744008545 active site 1127744008546 catalytic tetrad [active] 1127744008547 dephospho-CoA kinase; Region: TIGR00152 1127744008548 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1127744008549 CoA-binding site [chemical binding]; other site 1127744008550 ATP-binding [chemical binding]; other site 1127744008551 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1127744008552 Domain of unknown function DUF; Region: DUF204; pfam02659 1127744008553 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1127744008554 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1127744008555 DNA binding site [nucleotide binding] 1127744008556 catalytic residue [active] 1127744008557 H2TH interface [polypeptide binding]; other site 1127744008558 putative catalytic residues [active] 1127744008559 turnover-facilitating residue; other site 1127744008560 intercalation triad [nucleotide binding]; other site 1127744008561 8OG recognition residue [nucleotide binding]; other site 1127744008562 putative reading head residues; other site 1127744008563 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1127744008564 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1127744008565 DNA polymerase I; Provisional; Region: PRK05755 1127744008566 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1127744008567 active site 1127744008568 metal binding site 1 [ion binding]; metal-binding site 1127744008569 putative 5' ssDNA interaction site; other site 1127744008570 metal binding site 3; metal-binding site 1127744008571 metal binding site 2 [ion binding]; metal-binding site 1127744008572 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1127744008573 putative DNA binding site [nucleotide binding]; other site 1127744008574 putative metal binding site [ion binding]; other site 1127744008575 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1127744008576 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1127744008577 active site 1127744008578 DNA binding site [nucleotide binding] 1127744008579 catalytic site [active] 1127744008580 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1127744008581 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1127744008582 putative active site [active] 1127744008583 heme pocket [chemical binding]; other site 1127744008584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744008585 dimer interface [polypeptide binding]; other site 1127744008586 phosphorylation site [posttranslational modification] 1127744008587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744008588 ATP binding site [chemical binding]; other site 1127744008589 Mg2+ binding site [ion binding]; other site 1127744008590 G-X-G motif; other site 1127744008591 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127744008592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744008593 active site 1127744008594 phosphorylation site [posttranslational modification] 1127744008595 intermolecular recognition site; other site 1127744008596 dimerization interface [polypeptide binding]; other site 1127744008597 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127744008598 DNA binding site [nucleotide binding] 1127744008599 malate dehydrogenase; Reviewed; Region: PRK06223 1127744008600 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1127744008601 NAD(P) binding site [chemical binding]; other site 1127744008602 dimer interface [polypeptide binding]; other site 1127744008603 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1127744008604 substrate binding site [chemical binding]; other site 1127744008605 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1127744008606 isocitrate dehydrogenase; Validated; Region: PRK07362 1127744008607 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1127744008608 dimer interface [polypeptide binding]; other site 1127744008609 Citrate synthase; Region: Citrate_synt; pfam00285 1127744008610 active site 1127744008611 citrylCoA binding site [chemical binding]; other site 1127744008612 oxalacetate/citrate binding site [chemical binding]; other site 1127744008613 coenzyme A binding site [chemical binding]; other site 1127744008614 catalytic triad [active] 1127744008615 Predicted membrane protein [Function unknown]; Region: COG2707 1127744008616 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 1127744008617 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1127744008618 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1127744008619 pyruvate kinase; Provisional; Region: PRK06354 1127744008620 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1127744008621 domain interfaces; other site 1127744008622 active site 1127744008623 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1127744008624 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1127744008625 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1127744008626 active site 1127744008627 ADP/pyrophosphate binding site [chemical binding]; other site 1127744008628 dimerization interface [polypeptide binding]; other site 1127744008629 allosteric effector site; other site 1127744008630 fructose-1,6-bisphosphate binding site; other site 1127744008631 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1127744008632 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1127744008633 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1127744008634 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1127744008635 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1127744008636 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1127744008637 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1127744008638 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1127744008639 putative NAD(P) binding site [chemical binding]; other site 1127744008640 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1127744008641 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1127744008642 active site 1127744008643 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1127744008644 generic binding surface I; other site 1127744008645 generic binding surface II; other site 1127744008646 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1127744008647 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1127744008648 DHH family; Region: DHH; pfam01368 1127744008649 DHHA1 domain; Region: DHHA1; pfam02272 1127744008650 YtpI-like protein; Region: YtpI; pfam14007 1127744008651 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1127744008652 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744008653 DNA-binding site [nucleotide binding]; DNA binding site 1127744008654 DRTGG domain; Region: DRTGG; pfam07085 1127744008655 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1127744008656 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1127744008657 active site 2 [active] 1127744008658 active site 1 [active] 1127744008659 Predicted permeases [General function prediction only]; Region: COG0730 1127744008660 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1127744008661 amidohydrolase; Region: amidohydrolases; TIGR01891 1127744008662 metal binding site [ion binding]; metal-binding site 1127744008663 dimer interface [polypeptide binding]; other site 1127744008664 Riboflavin kinase; Region: Flavokinase; pfam01687 1127744008665 Riboflavin kinase; Region: Flavokinase; cl03312 1127744008666 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1127744008667 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1127744008668 active site 1127744008669 non-prolyl cis peptide bond; other site 1127744008670 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1127744008671 catalytic residues [active] 1127744008672 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1127744008673 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1127744008674 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1127744008675 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1127744008676 Walker A/P-loop; other site 1127744008677 ATP binding site [chemical binding]; other site 1127744008678 Q-loop/lid; other site 1127744008679 ABC transporter signature motif; other site 1127744008680 Walker B; other site 1127744008681 D-loop; other site 1127744008682 H-loop/switch region; other site 1127744008683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744008684 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1127744008685 dimer interface [polypeptide binding]; other site 1127744008686 conserved gate region; other site 1127744008687 putative PBP binding loops; other site 1127744008688 ABC-ATPase subunit interface; other site 1127744008689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744008690 dimer interface [polypeptide binding]; other site 1127744008691 conserved gate region; other site 1127744008692 putative PBP binding loops; other site 1127744008693 ABC-ATPase subunit interface; other site 1127744008694 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1127744008695 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1127744008696 substrate binding pocket [chemical binding]; other site 1127744008697 membrane-bound complex binding site; other site 1127744008698 hinge residues; other site 1127744008699 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1127744008700 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1127744008701 substrate binding pocket [chemical binding]; other site 1127744008702 membrane-bound complex binding site; other site 1127744008703 hinge residues; other site 1127744008704 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1127744008705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744008706 Coenzyme A binding pocket [chemical binding]; other site 1127744008707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744008708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744008709 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1127744008710 dimerization interface [polypeptide binding]; other site 1127744008711 metal-dependent hydrolase; Provisional; Region: PRK00685 1127744008712 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1127744008713 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1127744008714 classical (c) SDRs; Region: SDR_c; cd05233 1127744008715 NAD(P) binding site [chemical binding]; other site 1127744008716 active site 1127744008717 argininosuccinate lyase; Provisional; Region: PRK00855 1127744008718 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1127744008719 active sites [active] 1127744008720 tetramer interface [polypeptide binding]; other site 1127744008721 argininosuccinate synthase; Provisional; Region: PRK13820 1127744008722 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1127744008723 ANP binding site [chemical binding]; other site 1127744008724 Substrate Binding Site II [chemical binding]; other site 1127744008725 Substrate Binding Site I [chemical binding]; other site 1127744008726 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1127744008727 MPT binding site; other site 1127744008728 trimer interface [polypeptide binding]; other site 1127744008729 propionate/acetate kinase; Provisional; Region: PRK12379 1127744008730 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1127744008731 nucleotide binding site [chemical binding]; other site 1127744008732 butyrate kinase; Provisional; Region: PRK03011 1127744008733 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1127744008734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744008735 S-adenosylmethionine binding site [chemical binding]; other site 1127744008736 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1127744008737 dimer interface [polypeptide binding]; other site 1127744008738 catalytic triad [active] 1127744008739 peroxidatic and resolving cysteines [active] 1127744008740 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 1127744008741 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1127744008742 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1127744008743 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1127744008744 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1127744008745 tandem repeat interface [polypeptide binding]; other site 1127744008746 oligomer interface [polypeptide binding]; other site 1127744008747 active site residues [active] 1127744008748 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1127744008749 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1127744008750 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1127744008751 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1127744008752 active site 1127744008753 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1127744008754 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1127744008755 active site 1127744008756 acyl-activating enzyme (AAE) consensus motif; other site 1127744008757 putative CoA binding site [chemical binding]; other site 1127744008758 AMP binding site [chemical binding]; other site 1127744008759 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1127744008760 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1127744008761 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1127744008762 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1127744008763 Ligand Binding Site [chemical binding]; other site 1127744008764 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1127744008765 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1127744008766 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127744008767 catalytic residue [active] 1127744008768 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1127744008769 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1127744008770 histidinol-phosphatase; Reviewed; Region: PRK08123 1127744008771 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1127744008772 active site 1127744008773 dimer interface [polypeptide binding]; other site 1127744008774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744008775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744008776 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1127744008777 GAF domain; Region: GAF_2; pfam13185 1127744008778 GAF domain; Region: GAF_2; pfam13185 1127744008779 GAF domain; Region: GAF; cl17456 1127744008780 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1127744008781 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1127744008782 metal binding site [ion binding]; metal-binding site 1127744008783 active site 1127744008784 I-site; other site 1127744008785 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1127744008786 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1127744008787 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127744008788 RNA binding surface [nucleotide binding]; other site 1127744008789 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1127744008790 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1127744008791 active site 1127744008792 HIGH motif; other site 1127744008793 dimer interface [polypeptide binding]; other site 1127744008794 KMSKS motif; other site 1127744008795 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127744008796 RNA binding surface [nucleotide binding]; other site 1127744008797 acetyl-CoA synthetase; Provisional; Region: PRK04319 1127744008798 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1127744008799 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1127744008800 active site 1127744008801 acyl-activating enzyme (AAE) consensus motif; other site 1127744008802 putative CoA binding site [chemical binding]; other site 1127744008803 AMP binding site [chemical binding]; other site 1127744008804 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744008805 Coenzyme A binding pocket [chemical binding]; other site 1127744008806 FOG: CBS domain [General function prediction only]; Region: COG0517 1127744008807 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1127744008808 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1127744008809 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1127744008810 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1127744008811 active site 1127744008812 Zn binding site [ion binding]; other site 1127744008813 flagellar motor protein MotS; Reviewed; Region: PRK06925 1127744008814 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1127744008815 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1127744008816 ligand binding site [chemical binding]; other site 1127744008817 flagellar motor protein MotP; Reviewed; Region: PRK06926 1127744008818 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1127744008819 catabolite control protein A; Region: ccpA; TIGR01481 1127744008820 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1127744008821 DNA binding site [nucleotide binding] 1127744008822 domain linker motif; other site 1127744008823 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1127744008824 dimerization interface [polypeptide binding]; other site 1127744008825 effector binding site; other site 1127744008826 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1127744008827 chorismate mutase domain of gram positive AroA protein; Region: CM_A; TIGR01801 1127744008828 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1127744008829 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 1127744008830 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1127744008831 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1127744008832 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1127744008833 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1127744008834 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1127744008835 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1127744008836 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1127744008837 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1127744008838 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1127744008839 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1127744008840 putative tRNA-binding site [nucleotide binding]; other site 1127744008841 hypothetical protein; Provisional; Region: PRK13668 1127744008842 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1127744008843 catalytic residues [active] 1127744008844 YtoQ family protein; Region: YtoQ_fam; TIGR03646 1127744008845 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1127744008846 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1127744008847 oligomer interface [polypeptide binding]; other site 1127744008848 active site 1127744008849 metal binding site [ion binding]; metal-binding site 1127744008850 Predicted small secreted protein [Function unknown]; Region: COG5584 1127744008851 malate dehydrogenase; Provisional; Region: PRK13529 1127744008852 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1127744008853 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1127744008854 NAD(P) binding site [chemical binding]; other site 1127744008855 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1127744008856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744008857 S-adenosylmethionine binding site [chemical binding]; other site 1127744008858 YtzH-like protein; Region: YtzH; pfam14165 1127744008859 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1127744008860 active site 1127744008861 ATP binding site [chemical binding]; other site 1127744008862 Phosphotransferase enzyme family; Region: APH; pfam01636 1127744008863 substrate binding site [chemical binding]; other site 1127744008864 pullulanase, type I; Region: pulA_typeI; TIGR02104 1127744008865 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1127744008866 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1127744008867 Ca binding site [ion binding]; other site 1127744008868 active site 1127744008869 catalytic site [active] 1127744008870 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1127744008871 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1127744008872 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1127744008873 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1127744008874 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1127744008875 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1127744008876 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1127744008877 dimer interface [polypeptide binding]; other site 1127744008878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744008879 catalytic residue [active] 1127744008880 dipeptidase PepV; Reviewed; Region: PRK07318 1127744008881 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1127744008882 active site 1127744008883 metal binding site [ion binding]; metal-binding site 1127744008884 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1127744008885 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1127744008886 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1127744008887 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1127744008888 Walker A/P-loop; other site 1127744008889 ATP binding site [chemical binding]; other site 1127744008890 Q-loop/lid; other site 1127744008891 ABC transporter signature motif; other site 1127744008892 Walker B; other site 1127744008893 D-loop; other site 1127744008894 H-loop/switch region; other site 1127744008895 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1127744008896 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1127744008897 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1127744008898 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127744008899 RNA binding surface [nucleotide binding]; other site 1127744008900 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1127744008901 active site 1127744008902 uracil binding [chemical binding]; other site 1127744008903 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1127744008904 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1127744008905 Predicted flavoproteins [General function prediction only]; Region: COG2081 1127744008906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1127744008907 BCCT family transporter; Region: BCCT; pfam02028 1127744008908 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1127744008909 Predicted integral membrane protein [Function unknown]; Region: COG5578 1127744008910 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1127744008911 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1127744008912 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1127744008913 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1127744008914 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1127744008915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744008916 dimer interface [polypeptide binding]; other site 1127744008917 conserved gate region; other site 1127744008918 ABC-ATPase subunit interface; other site 1127744008919 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1127744008920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1127744008921 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1127744008922 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1127744008923 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1127744008924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744008925 dimer interface [polypeptide binding]; other site 1127744008926 conserved gate region; other site 1127744008927 putative PBP binding loops; other site 1127744008928 ABC-ATPase subunit interface; other site 1127744008929 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1127744008930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127744008931 NAD(P) binding site [chemical binding]; other site 1127744008932 active site 1127744008933 biotin synthase; Validated; Region: PRK06256 1127744008934 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127744008935 FeS/SAM binding site; other site 1127744008936 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1127744008937 AAA domain; Region: AAA_26; pfam13500 1127744008938 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1127744008939 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1127744008940 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1127744008941 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1127744008942 substrate-cofactor binding pocket; other site 1127744008943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744008944 catalytic residue [active] 1127744008945 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1127744008946 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127744008947 inhibitor-cofactor binding pocket; inhibition site 1127744008948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744008949 catalytic residue [active] 1127744008950 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1127744008951 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1127744008952 Abhydrolase family; Region: Abhydrolase_7; pfam12715 1127744008953 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1127744008954 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1127744008955 DNA binding site [nucleotide binding] 1127744008956 domain linker motif; other site 1127744008957 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1127744008958 putative ligand binding site [chemical binding]; other site 1127744008959 putative dimerization interface [polypeptide binding]; other site 1127744008960 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1127744008961 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1127744008962 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1127744008963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744008964 dimer interface [polypeptide binding]; other site 1127744008965 conserved gate region; other site 1127744008966 putative PBP binding loops; other site 1127744008967 ABC-ATPase subunit interface; other site 1127744008968 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1127744008969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744008970 dimer interface [polypeptide binding]; other site 1127744008971 conserved gate region; other site 1127744008972 putative PBP binding loops; other site 1127744008973 ABC-ATPase subunit interface; other site 1127744008974 alpha-galactosidase; Provisional; Region: PRK15076 1127744008975 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1127744008976 NAD binding site [chemical binding]; other site 1127744008977 sugar binding site [chemical binding]; other site 1127744008978 divalent metal binding site [ion binding]; other site 1127744008979 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1127744008980 dimer interface [polypeptide binding]; other site 1127744008981 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1127744008982 active site residue [active] 1127744008983 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1127744008984 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1127744008985 HIGH motif; other site 1127744008986 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1127744008987 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1127744008988 active site 1127744008989 KMSKS motif; other site 1127744008990 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1127744008991 tRNA binding surface [nucleotide binding]; other site 1127744008992 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1127744008993 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1127744008994 PAS domain; Region: PAS_9; pfam13426 1127744008995 putative active site [active] 1127744008996 heme pocket [chemical binding]; other site 1127744008997 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1127744008998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744008999 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744009000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744009001 putative substrate translocation pore; other site 1127744009002 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1127744009003 FtsX-like permease family; Region: FtsX; pfam02687 1127744009004 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1127744009005 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1127744009006 Walker A/P-loop; other site 1127744009007 ATP binding site [chemical binding]; other site 1127744009008 Q-loop/lid; other site 1127744009009 ABC transporter signature motif; other site 1127744009010 Walker B; other site 1127744009011 D-loop; other site 1127744009012 H-loop/switch region; other site 1127744009013 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1127744009014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744009015 ATP binding site [chemical binding]; other site 1127744009016 Mg2+ binding site [ion binding]; other site 1127744009017 G-X-G motif; other site 1127744009018 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127744009019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744009020 active site 1127744009021 phosphorylation site [posttranslational modification] 1127744009022 intermolecular recognition site; other site 1127744009023 dimerization interface [polypeptide binding]; other site 1127744009024 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127744009025 DNA binding site [nucleotide binding] 1127744009026 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1127744009027 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1127744009028 FtsX-like permease family; Region: FtsX; pfam02687 1127744009029 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1127744009030 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1127744009031 Walker A/P-loop; other site 1127744009032 ATP binding site [chemical binding]; other site 1127744009033 Q-loop/lid; other site 1127744009034 ABC transporter signature motif; other site 1127744009035 Walker B; other site 1127744009036 D-loop; other site 1127744009037 H-loop/switch region; other site 1127744009038 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1127744009039 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1127744009040 Walker A/P-loop; other site 1127744009041 ATP binding site [chemical binding]; other site 1127744009042 Q-loop/lid; other site 1127744009043 ABC transporter signature motif; other site 1127744009044 Walker B; other site 1127744009045 D-loop; other site 1127744009046 H-loop/switch region; other site 1127744009047 Predicted transcriptional regulators [Transcription]; Region: COG1725 1127744009048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744009049 DNA-binding site [nucleotide binding]; DNA binding site 1127744009050 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1127744009051 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1127744009052 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1127744009053 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1127744009054 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1127744009055 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1127744009056 PGAP1-like protein; Region: PGAP1; pfam07819 1127744009057 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1127744009058 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1127744009059 trimer interface [polypeptide binding]; other site 1127744009060 putative metal binding site [ion binding]; other site 1127744009061 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1127744009062 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1127744009063 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1127744009064 active site 1127744009065 dimer interface [polypeptide binding]; other site 1127744009066 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1127744009067 Ligand Binding Site [chemical binding]; other site 1127744009068 Molecular Tunnel; other site 1127744009069 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1127744009070 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1127744009071 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1127744009072 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1127744009073 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1127744009074 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1127744009075 active site 1127744009076 substrate-binding site [chemical binding]; other site 1127744009077 metal-binding site [ion binding] 1127744009078 ATP binding site [chemical binding]; other site 1127744009079 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1127744009080 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1127744009081 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1127744009082 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1127744009083 NMT1-like family; Region: NMT1_2; pfam13379 1127744009084 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1127744009085 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1127744009086 Walker A/P-loop; other site 1127744009087 ATP binding site [chemical binding]; other site 1127744009088 Q-loop/lid; other site 1127744009089 ABC transporter signature motif; other site 1127744009090 Walker B; other site 1127744009091 D-loop; other site 1127744009092 H-loop/switch region; other site 1127744009093 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1127744009094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744009095 dimer interface [polypeptide binding]; other site 1127744009096 conserved gate region; other site 1127744009097 putative PBP binding loops; other site 1127744009098 ABC-ATPase subunit interface; other site 1127744009099 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1127744009100 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1127744009101 nudix motif; other site 1127744009102 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1127744009103 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1127744009104 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1127744009105 dimerization interface [polypeptide binding]; other site 1127744009106 DPS ferroxidase diiron center [ion binding]; other site 1127744009107 ion pore; other site 1127744009108 YtkA-like; Region: YtkA; pfam13115 1127744009109 S-Ribosylhomocysteinase (LuxS); Region: LuxS; pfam02664 1127744009110 Haemolytic domain; Region: Haemolytic; pfam01809 1127744009111 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1127744009112 active site clefts [active] 1127744009113 zinc binding site [ion binding]; other site 1127744009114 dimer interface [polypeptide binding]; other site 1127744009115 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1127744009116 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1127744009117 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1127744009118 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1127744009119 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1127744009120 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127744009121 ABC-ATPase subunit interface; other site 1127744009122 dimer interface [polypeptide binding]; other site 1127744009123 putative PBP binding regions; other site 1127744009124 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1127744009125 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127744009126 ABC-ATPase subunit interface; other site 1127744009127 dimer interface [polypeptide binding]; other site 1127744009128 putative PBP binding regions; other site 1127744009129 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1127744009130 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1127744009131 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1127744009132 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 1127744009133 metal binding site [ion binding]; metal-binding site 1127744009134 intersubunit interface [polypeptide binding]; other site 1127744009135 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1127744009136 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1127744009137 active site 1127744009138 octamer interface [polypeptide binding]; other site 1127744009139 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1127744009140 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1127744009141 acyl-activating enzyme (AAE) consensus motif; other site 1127744009142 putative AMP binding site [chemical binding]; other site 1127744009143 putative active site [active] 1127744009144 putative CoA binding site [chemical binding]; other site 1127744009145 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127744009146 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1127744009147 substrate binding site [chemical binding]; other site 1127744009148 oxyanion hole (OAH) forming residues; other site 1127744009149 trimer interface [polypeptide binding]; other site 1127744009150 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1127744009151 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1127744009152 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 1127744009153 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1127744009154 dimer interface [polypeptide binding]; other site 1127744009155 tetramer interface [polypeptide binding]; other site 1127744009156 PYR/PP interface [polypeptide binding]; other site 1127744009157 TPP binding site [chemical binding]; other site 1127744009158 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1127744009159 TPP-binding site; other site 1127744009160 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1127744009161 isochorismate synthases; Region: isochor_syn; TIGR00543 1127744009162 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 1127744009163 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1127744009164 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1127744009165 active site 1127744009166 tetramer interface; other site 1127744009167 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1127744009168 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1127744009169 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1127744009170 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1127744009171 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1127744009172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1127744009173 NAD(P) binding site [chemical binding]; other site 1127744009174 active site 1127744009175 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1127744009176 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1127744009177 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1127744009178 spore coat protein YutH; Region: spore_yutH; TIGR02905 1127744009179 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1127744009180 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1127744009181 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1127744009182 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1127744009183 TspO/MBR family; Region: TspO_MBR; cl01379 1127744009184 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1127744009185 homodimer interface [polypeptide binding]; other site 1127744009186 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1127744009187 active site pocket [active] 1127744009188 glycogen synthase; Provisional; Region: glgA; PRK00654 1127744009189 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1127744009190 ADP-binding pocket [chemical binding]; other site 1127744009191 homodimer interface [polypeptide binding]; other site 1127744009192 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1127744009193 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1127744009194 ligand binding site; other site 1127744009195 oligomer interface; other site 1127744009196 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1127744009197 dimer interface [polypeptide binding]; other site 1127744009198 N-terminal domain interface [polypeptide binding]; other site 1127744009199 sulfate 1 binding site; other site 1127744009200 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1127744009201 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1127744009202 ligand binding site; other site 1127744009203 oligomer interface; other site 1127744009204 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1127744009205 dimer interface [polypeptide binding]; other site 1127744009206 N-terminal domain interface [polypeptide binding]; other site 1127744009207 sulfate 1 binding site; other site 1127744009208 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 1127744009209 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1127744009210 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1127744009211 active site 1127744009212 catalytic site [active] 1127744009213 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1127744009214 potential protein location (hypothetical protein MY9_3105 [Bacillus sp. JS]) that overlaps RNA (tRNA-E) 1127744009215 Predicted membrane protein [Function unknown]; Region: COG3859 1127744009216 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1127744009217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744009218 Coenzyme A binding pocket [chemical binding]; other site 1127744009219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1127744009220 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1127744009221 DinB superfamily; Region: DinB_2; pfam12867 1127744009222 MOSC domain; Region: MOSC; pfam03473 1127744009223 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1127744009224 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1127744009225 active site 1127744009226 NAD binding site [chemical binding]; other site 1127744009227 metal binding site [ion binding]; metal-binding site 1127744009228 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1127744009229 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1127744009230 tetramerization interface [polypeptide binding]; other site 1127744009231 NAD(P) binding site [chemical binding]; other site 1127744009232 catalytic residues [active] 1127744009233 Predicted transcriptional regulators [Transcription]; Region: COG1510 1127744009234 MarR family; Region: MarR_2; pfam12802 1127744009235 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1127744009236 TrkA-N domain; Region: TrkA_N; pfam02254 1127744009237 TrkA-C domain; Region: TrkA_C; pfam02080 1127744009238 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1127744009239 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1127744009240 Predicted membrane protein [Function unknown]; Region: COG4682 1127744009241 yiaA/B two helix domain; Region: YiaAB; pfam05360 1127744009242 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1127744009243 SH3-like domain; Region: SH3_8; pfam13457 1127744009244 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744009245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744009246 putative substrate translocation pore; other site 1127744009247 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1127744009248 undecaprenyl-diphosphatase UppP; Region: undec_PP_bacA; TIGR00753 1127744009249 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1127744009250 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1127744009251 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1127744009252 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1127744009253 L-rhamnose isomerase; Provisional; Region: PRK01076 1127744009254 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1127744009255 Domain of unknown function (DUF718); Region: DUF718; cl01281 1127744009256 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1127744009257 N- and C-terminal domain interface [polypeptide binding]; other site 1127744009258 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1127744009259 active site 1127744009260 putative catalytic site [active] 1127744009261 metal binding site [ion binding]; metal-binding site 1127744009262 ATP binding site [chemical binding]; other site 1127744009263 carbohydrate binding site [chemical binding]; other site 1127744009264 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1127744009265 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1127744009266 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1127744009267 short chain dehydrogenase; Validated; Region: PRK08324 1127744009268 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1127744009269 active site 1127744009270 intersubunit interface [polypeptide binding]; other site 1127744009271 Zn2+ binding site [ion binding]; other site 1127744009272 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 1127744009273 putative NAD(P) binding site [chemical binding]; other site 1127744009274 active site 1127744009275 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1127744009276 Cache domain; Region: Cache_1; pfam02743 1127744009277 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744009278 dimerization interface [polypeptide binding]; other site 1127744009279 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1127744009280 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1127744009281 dimer interface [polypeptide binding]; other site 1127744009282 putative CheW interface [polypeptide binding]; other site 1127744009283 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1127744009284 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1127744009285 Cache domain; Region: Cache_1; pfam02743 1127744009286 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744009287 dimerization interface [polypeptide binding]; other site 1127744009288 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1127744009289 dimer interface [polypeptide binding]; other site 1127744009290 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1127744009291 putative CheW interface [polypeptide binding]; other site 1127744009292 Tar ligand binding domain homologue; Region: TarH; pfam02203 1127744009293 Cache domain; Region: Cache_1; pfam02743 1127744009294 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744009295 dimerization interface [polypeptide binding]; other site 1127744009296 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1127744009297 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1127744009298 dimer interface [polypeptide binding]; other site 1127744009299 putative CheW interface [polypeptide binding]; other site 1127744009300 Homologues of the ligand binding domain of Tar; Region: TarH; smart00319 1127744009301 Cache domain; Region: Cache_1; pfam02743 1127744009302 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744009303 dimerization interface [polypeptide binding]; other site 1127744009304 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1127744009305 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1127744009306 dimer interface [polypeptide binding]; other site 1127744009307 putative CheW interface [polypeptide binding]; other site 1127744009308 transglutaminase; Provisional; Region: tgl; PRK03187 1127744009309 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1127744009310 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1127744009311 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1127744009312 Ca binding site [ion binding]; other site 1127744009313 active site 1127744009314 catalytic site [active] 1127744009315 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1127744009316 Domain of unknown function DUF21; Region: DUF21; pfam01595 1127744009317 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1127744009318 Transporter associated domain; Region: CorC_HlyC; smart01091 1127744009319 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1127744009320 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1127744009321 Ion channel; Region: Ion_trans_2; pfam07885 1127744009322 TrkA-N domain; Region: TrkA_N; pfam02254 1127744009323 YugN-like family; Region: YugN; pfam08868 1127744009324 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1127744009325 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1127744009326 active site 1127744009327 dimer interface [polypeptide binding]; other site 1127744009328 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1127744009329 dimer interface [polypeptide binding]; other site 1127744009330 active site 1127744009331 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1127744009332 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1127744009333 dimer interface [polypeptide binding]; other site 1127744009334 active site 1127744009335 metal binding site [ion binding]; metal-binding site 1127744009336 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1127744009337 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1127744009338 dimer interface [polypeptide binding]; other site 1127744009339 active site 1127744009340 metal binding site [ion binding]; metal-binding site 1127744009341 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1127744009342 general stress protein 13; Validated; Region: PRK08059 1127744009343 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1127744009344 RNA binding site [nucleotide binding]; other site 1127744009345 hypothetical protein; Validated; Region: PRK07682 1127744009346 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127744009347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744009348 homodimer interface [polypeptide binding]; other site 1127744009349 catalytic residue [active] 1127744009350 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1127744009351 AsnC family; Region: AsnC_trans_reg; pfam01037 1127744009352 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1127744009353 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1127744009354 nucleophilic elbow; other site 1127744009355 catalytic triad; other site 1127744009356 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1127744009357 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1127744009358 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127744009359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744009360 homodimer interface [polypeptide binding]; other site 1127744009361 catalytic residue [active] 1127744009362 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1127744009363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744009364 dimer interface [polypeptide binding]; other site 1127744009365 phosphorylation site [posttranslational modification] 1127744009366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744009367 ATP binding site [chemical binding]; other site 1127744009368 Mg2+ binding site [ion binding]; other site 1127744009369 G-X-G motif; other site 1127744009370 Kinase associated protein B; Region: KapB; pfam08810 1127744009371 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1127744009372 active site 1127744009373 catalytic site [active] 1127744009374 substrate binding site [chemical binding]; other site 1127744009375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744009376 putative substrate translocation pore; other site 1127744009377 Transglycosylase; Region: Transgly; pfam00912 1127744009378 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1127744009379 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1127744009380 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1127744009381 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1127744009382 PAS domain; Region: PAS; smart00091 1127744009383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744009384 ATP binding site [chemical binding]; other site 1127744009385 G-X-G motif; other site 1127744009386 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1127744009387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744009388 active site 1127744009389 phosphorylation site [posttranslational modification] 1127744009390 intermolecular recognition site; other site 1127744009391 dimerization interface [polypeptide binding]; other site 1127744009392 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1127744009393 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1127744009394 ligand binding site [chemical binding]; other site 1127744009395 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1127744009396 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1127744009397 Walker A/P-loop; other site 1127744009398 ATP binding site [chemical binding]; other site 1127744009399 Q-loop/lid; other site 1127744009400 ABC transporter signature motif; other site 1127744009401 Walker B; other site 1127744009402 D-loop; other site 1127744009403 H-loop/switch region; other site 1127744009404 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1127744009405 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1127744009406 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1127744009407 TM-ABC transporter signature motif; other site 1127744009408 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1127744009409 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1127744009410 TM-ABC transporter signature motif; other site 1127744009411 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1127744009412 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1127744009413 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1127744009414 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1127744009415 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1127744009416 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1127744009417 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1127744009418 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1127744009419 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1127744009420 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1127744009421 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 1127744009422 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1127744009423 CoenzymeA binding site [chemical binding]; other site 1127744009424 subunit interaction site [polypeptide binding]; other site 1127744009425 PHB binding site; other site 1127744009426 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127744009427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744009428 active site 1127744009429 phosphorylation site [posttranslational modification] 1127744009430 intermolecular recognition site; other site 1127744009431 dimerization interface [polypeptide binding]; other site 1127744009432 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127744009433 DNA binding residues [nucleotide binding] 1127744009434 dimerization interface [polypeptide binding]; other site 1127744009435 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1127744009436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127744009437 Histidine kinase; Region: HisKA_3; pfam07730 1127744009438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744009439 ATP binding site [chemical binding]; other site 1127744009440 Mg2+ binding site [ion binding]; other site 1127744009441 G-X-G motif; other site 1127744009442 Bacillus competence pheromone ComX; Region: ComX; pfam05952 1127744009443 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1127744009444 substrate binding pocket [chemical binding]; other site 1127744009445 substrate-Mg2+ binding site; other site 1127744009446 aspartate-rich region 1; other site 1127744009447 aspartate-rich region 2; other site 1127744009448 DegQ (SacQ) family; Region: DegQ; pfam08181 1127744009449 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1127744009450 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1127744009451 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1127744009452 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1127744009453 active site 1127744009454 Isochorismatase family; Region: Isochorismatase; pfam00857 1127744009455 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1127744009456 catalytic triad [active] 1127744009457 conserved cis-peptide bond; other site 1127744009458 Uncharacterized conserved protein [Function unknown]; Region: COG5506 1127744009459 YueH-like protein; Region: YueH; pfam14166 1127744009460 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1127744009461 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1127744009462 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1127744009463 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 1127744009464 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1127744009465 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1127744009466 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1127744009467 Zn2+ binding site [ion binding]; other site 1127744009468 Mg2+ binding site [ion binding]; other site 1127744009469 short chain dehydrogenase; Provisional; Region: PRK06924 1127744009470 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1127744009471 NADP binding site [chemical binding]; other site 1127744009472 homodimer interface [polypeptide binding]; other site 1127744009473 active site 1127744009474 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1127744009475 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1127744009476 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1127744009477 Predicted membrane protein [Function unknown]; Region: COG1511 1127744009478 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 1127744009479 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1127744009480 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1127744009481 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1127744009482 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1127744009483 Domain of unknown function DUF87; Region: DUF87; pfam01935 1127744009484 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1127744009485 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1127744009486 Uncharacterized small protein [Function unknown]; Region: COG5417 1127744009487 Ubiquitin homologues; Region: UBQ; smart00213 1127744009488 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1127744009489 CodY GAF-like domain; Region: CodY; pfam06018 1127744009490 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1127744009491 alanine dehydrogenase; Region: alaDH; TIGR00518 1127744009492 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1127744009493 hexamer interface [polypeptide binding]; other site 1127744009494 ligand binding site [chemical binding]; other site 1127744009495 putative active site [active] 1127744009496 NAD(P) binding site [chemical binding]; other site 1127744009497 Uncharacterized conserved protein [Function unknown]; Region: COG5634 1127744009498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1127744009499 Condensation domain; Region: Condensation; pfam00668 1127744009500 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1127744009501 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1127744009502 acyl-activating enzyme (AAE) consensus motif; other site 1127744009503 AMP binding site [chemical binding]; other site 1127744009504 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744009505 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1127744009506 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1127744009507 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1127744009508 acyl-activating enzyme (AAE) consensus motif; other site 1127744009509 AMP binding site [chemical binding]; other site 1127744009510 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1127744009511 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1127744009512 hydrophobic substrate binding pocket; other site 1127744009513 Isochorismatase family; Region: Isochorismatase; pfam00857 1127744009514 active site 1127744009515 conserved cis-peptide bond; other site 1127744009516 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1127744009517 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 1127744009518 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1127744009519 acyl-activating enzyme (AAE) consensus motif; other site 1127744009520 active site 1127744009521 AMP binding site [chemical binding]; other site 1127744009522 substrate binding site [chemical binding]; other site 1127744009523 isochorismate synthase DhbC; Validated; Region: PRK06923 1127744009524 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1127744009525 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1127744009526 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1127744009527 putative NAD(P) binding site [chemical binding]; other site 1127744009528 active site 1127744009529 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1127744009530 Putative esterase; Region: Esterase; pfam00756 1127744009531 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1127744009532 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1127744009533 Moco binding site; other site 1127744009534 metal coordination site [ion binding]; other site 1127744009535 Predicted permease [General function prediction only]; Region: COG2056 1127744009536 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1127744009537 AbgT putative transporter family; Region: ABG_transport; cl17431 1127744009538 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1127744009539 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1127744009540 interface (dimer of trimers) [polypeptide binding]; other site 1127744009541 Substrate-binding/catalytic site; other site 1127744009542 Zn-binding sites [ion binding]; other site 1127744009543 Divergent PAP2 family; Region: DUF212; pfam02681 1127744009544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1127744009545 Putative membrane protein; Region: YuiB; pfam14068 1127744009546 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 1127744009547 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1127744009548 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127744009549 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1127744009550 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1127744009551 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127744009552 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1127744009553 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1127744009554 active site 1127744009555 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 1127744009556 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1127744009557 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744009558 Coenzyme A binding pocket [chemical binding]; other site 1127744009559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1127744009560 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1127744009561 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1127744009562 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1127744009563 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1127744009564 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1127744009565 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1127744009566 Nucleoside recognition; Region: Gate; pfam07670 1127744009567 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1127744009568 hypothetical protein; Provisional; Region: PRK13669 1127744009569 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1127744009570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127744009571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1127744009572 NifU-like domain; Region: NifU; pfam01106 1127744009573 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1127744009574 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1127744009575 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1127744009576 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1127744009577 homoserine kinase; Region: thrB; TIGR00191 1127744009578 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1127744009579 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1127744009580 threonine synthase; Reviewed; Region: PRK06721 1127744009581 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1127744009582 homodimer interface [polypeptide binding]; other site 1127744009583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744009584 catalytic residue [active] 1127744009585 homoserine dehydrogenase; Provisional; Region: PRK06349 1127744009586 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1127744009587 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1127744009588 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1127744009589 spore coat protein YutH; Region: spore_yutH; TIGR02905 1127744009590 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1127744009591 tetramer interfaces [polypeptide binding]; other site 1127744009592 binuclear metal-binding site [ion binding]; other site 1127744009593 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1127744009594 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744009595 active site 1127744009596 motif I; other site 1127744009597 motif II; other site 1127744009598 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744009599 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1127744009600 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1127744009601 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1127744009602 lipoyl synthase; Provisional; Region: PRK05481 1127744009603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127744009604 FeS/SAM binding site; other site 1127744009605 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1127744009606 Peptidase family M23; Region: Peptidase_M23; pfam01551 1127744009607 sporulation protein YunB; Region: spo_yunB; TIGR02832 1127744009608 Uncharacterized conserved protein [Function unknown]; Region: COG3377 1127744009609 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1127744009610 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1127744009611 active site 1127744009612 metal binding site [ion binding]; metal-binding site 1127744009613 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1127744009614 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1127744009615 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1127744009616 allantoinase; Provisional; Region: PRK06189 1127744009617 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1127744009618 active site 1127744009619 DRTGG domain; Region: DRTGG; pfam07085 1127744009620 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1127744009621 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1127744009622 xanthine permease; Region: pbuX; TIGR03173 1127744009623 xanthine permease; Region: pbuX; TIGR03173 1127744009624 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1127744009625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 1127744009626 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 1127744009627 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1127744009628 active site 1127744009629 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1127744009630 active site 1127744009631 homotetramer interface [polypeptide binding]; other site 1127744009632 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1127744009633 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744009634 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744009635 DNA binding residues [nucleotide binding] 1127744009636 SpaB C-terminal domain; Region: SpaB_C; pfam14028 1127744009637 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1127744009638 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1127744009639 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1127744009640 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1127744009641 active site 1127744009642 Nitroreductase family; Region: Nitroreductase; pfam00881 1127744009643 FMN binding site [chemical binding]; other site 1127744009644 dimer interface [polypeptide binding]; other site 1127744009645 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1127744009646 NADPH bind site [chemical binding]; other site 1127744009647 putative FMN binding site [chemical binding]; other site 1127744009648 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1127744009649 YcaO-like family; Region: YcaO; pfam02624 1127744009650 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1127744009651 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127744009652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127744009653 DNA binding site [nucleotide binding] 1127744009654 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1127744009655 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1127744009656 Walker A/P-loop; other site 1127744009657 ATP binding site [chemical binding]; other site 1127744009658 Q-loop/lid; other site 1127744009659 ABC transporter signature motif; other site 1127744009660 Walker B; other site 1127744009661 D-loop; other site 1127744009662 H-loop/switch region; other site 1127744009663 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1127744009664 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1127744009665 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 1127744009666 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1127744009667 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1127744009668 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 1127744009669 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1127744009670 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1127744009671 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 1127744009672 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1127744009673 Ligand binding site; other site 1127744009674 metal-binding site 1127744009675 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1127744009676 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1127744009677 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1127744009678 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1127744009679 homodimer interface [polypeptide binding]; other site 1127744009680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744009681 catalytic residue [active] 1127744009682 allantoate amidohydrolase; Reviewed; Region: PRK09290 1127744009683 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1127744009684 active site 1127744009685 metal binding site [ion binding]; metal-binding site 1127744009686 dimer interface [polypeptide binding]; other site 1127744009687 Endonuclease I; Region: Endonuclease_1; cl01003 1127744009688 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1127744009689 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1127744009690 Walker A/P-loop; other site 1127744009691 ATP binding site [chemical binding]; other site 1127744009692 Q-loop/lid; other site 1127744009693 ABC transporter signature motif; other site 1127744009694 Walker B; other site 1127744009695 D-loop; other site 1127744009696 H-loop/switch region; other site 1127744009697 TOBE domain; Region: TOBE_2; pfam08402 1127744009698 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1127744009699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744009700 DNA-binding site [nucleotide binding]; DNA binding site 1127744009701 UTRA domain; Region: UTRA; pfam07702 1127744009702 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1127744009703 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1127744009704 substrate binding site [chemical binding]; other site 1127744009705 ATP binding site [chemical binding]; other site 1127744009706 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1127744009707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744009708 dimer interface [polypeptide binding]; other site 1127744009709 conserved gate region; other site 1127744009710 putative PBP binding loops; other site 1127744009711 ABC-ATPase subunit interface; other site 1127744009712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744009713 dimer interface [polypeptide binding]; other site 1127744009714 conserved gate region; other site 1127744009715 putative PBP binding loops; other site 1127744009716 ABC-ATPase subunit interface; other site 1127744009717 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1127744009718 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1127744009719 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1127744009720 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1127744009721 putative active site [active] 1127744009722 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1127744009723 dimer interface [polypeptide binding]; other site 1127744009724 active site 1127744009725 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1127744009726 active site 1127744009727 catalytic site [active] 1127744009728 putative DNA binding site [nucleotide binding]; other site 1127744009729 GIY-YIG motif/motif A; other site 1127744009730 metal binding site [ion binding]; metal-binding site 1127744009731 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1127744009732 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1127744009733 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1127744009734 FeS assembly protein SufB; Region: sufB; TIGR01980 1127744009735 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1127744009736 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1127744009737 trimerization site [polypeptide binding]; other site 1127744009738 active site 1127744009739 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1127744009740 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1127744009741 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1127744009742 catalytic residue [active] 1127744009743 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1127744009744 FeS assembly protein SufD; Region: sufD; TIGR01981 1127744009745 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1127744009746 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1127744009747 Walker A/P-loop; other site 1127744009748 ATP binding site [chemical binding]; other site 1127744009749 Q-loop/lid; other site 1127744009750 ABC transporter signature motif; other site 1127744009751 Walker B; other site 1127744009752 D-loop; other site 1127744009753 H-loop/switch region; other site 1127744009754 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1127744009755 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1127744009756 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1127744009757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744009758 conserved gate region; other site 1127744009759 ABC-ATPase subunit interface; other site 1127744009760 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1127744009761 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1127744009762 Walker A/P-loop; other site 1127744009763 ATP binding site [chemical binding]; other site 1127744009764 Q-loop/lid; other site 1127744009765 ABC transporter signature motif; other site 1127744009766 Walker B; other site 1127744009767 D-loop; other site 1127744009768 H-loop/switch region; other site 1127744009769 NIL domain; Region: NIL; pfam09383 1127744009770 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1127744009771 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1127744009772 catalytic residues [active] 1127744009773 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1127744009774 putative active site [active] 1127744009775 putative metal binding site [ion binding]; other site 1127744009776 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1127744009777 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1127744009778 lipoyl attachment site [posttranslational modification]; other site 1127744009779 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1127744009780 ArsC family; Region: ArsC; pfam03960 1127744009781 putative ArsC-like catalytic residues; other site 1127744009782 putative TRX-like catalytic residues [active] 1127744009783 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1127744009784 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127744009785 active site 1127744009786 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1127744009787 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1127744009788 dimer interface [polypeptide binding]; other site 1127744009789 active site 1127744009790 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1127744009791 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1127744009792 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1127744009793 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1127744009794 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1127744009795 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1127744009796 substrate binding site [chemical binding]; other site 1127744009797 oxyanion hole (OAH) forming residues; other site 1127744009798 trimer interface [polypeptide binding]; other site 1127744009799 Proline dehydrogenase; Region: Pro_dh; pfam01619 1127744009800 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1127744009801 dinuclear metal binding motif [ion binding]; other site 1127744009802 Coat F domain; Region: Coat_F; pfam07875 1127744009803 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744009804 MarR family; Region: MarR; pfam01047 1127744009805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744009806 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744009807 putative substrate translocation pore; other site 1127744009808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744009809 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1127744009810 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1127744009811 classical (c) SDRs; Region: SDR_c; cd05233 1127744009812 NAD(P) binding site [chemical binding]; other site 1127744009813 active site 1127744009814 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744009815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744009816 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1127744009817 dimerization interface [polypeptide binding]; other site 1127744009818 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1127744009819 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1127744009820 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1127744009821 Walker A/P-loop; other site 1127744009822 ATP binding site [chemical binding]; other site 1127744009823 Q-loop/lid; other site 1127744009824 ABC transporter signature motif; other site 1127744009825 Walker B; other site 1127744009826 D-loop; other site 1127744009827 H-loop/switch region; other site 1127744009828 YusW-like protein; Region: YusW; pfam14039 1127744009829 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1127744009830 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1127744009831 active site 1127744009832 Zn binding site [ion binding]; other site 1127744009833 short chain dehydrogenase; Provisional; Region: PRK06914 1127744009834 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1127744009835 NADP binding site [chemical binding]; other site 1127744009836 active site 1127744009837 steroid binding site; other site 1127744009838 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1127744009839 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1127744009840 dimerization interface [polypeptide binding]; other site 1127744009841 DPS ferroxidase diiron center [ion binding]; other site 1127744009842 ion pore; other site 1127744009843 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1127744009844 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1127744009845 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1127744009846 protein binding site [polypeptide binding]; other site 1127744009847 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127744009848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744009849 active site 1127744009850 phosphorylation site [posttranslational modification] 1127744009851 intermolecular recognition site; other site 1127744009852 dimerization interface [polypeptide binding]; other site 1127744009853 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127744009854 DNA binding site [nucleotide binding] 1127744009855 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1127744009856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744009857 dimerization interface [polypeptide binding]; other site 1127744009858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744009859 dimer interface [polypeptide binding]; other site 1127744009860 phosphorylation site [posttranslational modification] 1127744009861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744009862 ATP binding site [chemical binding]; other site 1127744009863 Mg2+ binding site [ion binding]; other site 1127744009864 G-X-G motif; other site 1127744009865 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744009866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744009867 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1127744009868 Class II fumarases; Region: Fumarase_classII; cd01362 1127744009869 active site 1127744009870 tetramer interface [polypeptide binding]; other site 1127744009871 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1127744009872 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1127744009873 Spore germination protein; Region: Spore_permease; pfam03845 1127744009874 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1127744009875 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1127744009876 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127744009877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744009878 active site 1127744009879 phosphorylation site [posttranslational modification] 1127744009880 intermolecular recognition site; other site 1127744009881 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127744009882 DNA binding residues [nucleotide binding] 1127744009883 dimerization interface [polypeptide binding]; other site 1127744009884 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127744009885 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744009886 dimerization interface [polypeptide binding]; other site 1127744009887 Histidine kinase; Region: HisKA_3; pfam07730 1127744009888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744009889 ATP binding site [chemical binding]; other site 1127744009890 Mg2+ binding site [ion binding]; other site 1127744009891 G-X-G motif; other site 1127744009892 Predicted membrane protein [Function unknown]; Region: COG4758 1127744009893 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 1127744009894 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1127744009895 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1127744009896 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1127744009897 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1127744009898 PspA/IM30 family; Region: PspA_IM30; pfam04012 1127744009899 H+ Antiporter protein; Region: 2A0121; TIGR00900 1127744009900 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 1127744009901 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1127744009902 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1127744009903 Walker A/P-loop; other site 1127744009904 ATP binding site [chemical binding]; other site 1127744009905 Q-loop/lid; other site 1127744009906 ABC transporter signature motif; other site 1127744009907 Walker B; other site 1127744009908 D-loop; other site 1127744009909 H-loop/switch region; other site 1127744009910 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 1127744009911 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1127744009912 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127744009913 ABC-ATPase subunit interface; other site 1127744009914 dimer interface [polypeptide binding]; other site 1127744009915 putative PBP binding regions; other site 1127744009916 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1127744009917 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1127744009918 putative binding site residues; other site 1127744009919 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1127744009920 classical (c) SDRs; Region: SDR_c; cd05233 1127744009921 NAD(P) binding site [chemical binding]; other site 1127744009922 active site 1127744009923 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1127744009924 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1127744009925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744009926 dimer interface [polypeptide binding]; other site 1127744009927 phosphorylation site [posttranslational modification] 1127744009928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744009929 ATP binding site [chemical binding]; other site 1127744009930 Mg2+ binding site [ion binding]; other site 1127744009931 G-X-G motif; other site 1127744009932 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127744009933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744009934 active site 1127744009935 phosphorylation site [posttranslational modification] 1127744009936 intermolecular recognition site; other site 1127744009937 dimerization interface [polypeptide binding]; other site 1127744009938 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127744009939 DNA binding site [nucleotide binding] 1127744009940 hypothetical protein; Provisional; Region: PRK14082 1127744009941 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1127744009942 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744009943 DNA binding residues [nucleotide binding] 1127744009944 YvrJ protein family; Region: YvrJ; pfam12841 1127744009945 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1127744009946 Cupin; Region: Cupin_1; smart00835 1127744009947 Cupin; Region: Cupin_1; smart00835 1127744009948 Regulatory protein YrvL; Region: YrvL; pfam14184 1127744009949 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1127744009950 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1127744009951 FtsX-like permease family; Region: FtsX; pfam02687 1127744009952 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1127744009953 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1127744009954 Walker A/P-loop; other site 1127744009955 ATP binding site [chemical binding]; other site 1127744009956 Q-loop/lid; other site 1127744009957 ABC transporter signature motif; other site 1127744009958 Walker B; other site 1127744009959 D-loop; other site 1127744009960 H-loop/switch region; other site 1127744009961 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1127744009962 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1127744009963 HlyD family secretion protein; Region: HlyD_3; pfam13437 1127744009964 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1127744009965 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1127744009966 Walker A/P-loop; other site 1127744009967 ATP binding site [chemical binding]; other site 1127744009968 Q-loop/lid; other site 1127744009969 ABC transporter signature motif; other site 1127744009970 Walker B; other site 1127744009971 D-loop; other site 1127744009972 H-loop/switch region; other site 1127744009973 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1127744009974 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127744009975 ABC-ATPase subunit interface; other site 1127744009976 dimer interface [polypeptide binding]; other site 1127744009977 putative PBP binding regions; other site 1127744009978 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1127744009979 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1127744009980 ABC-ATPase subunit interface; other site 1127744009981 dimer interface [polypeptide binding]; other site 1127744009982 putative PBP binding regions; other site 1127744009983 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1127744009984 putative ligand binding residues [chemical binding]; other site 1127744009985 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1127744009986 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1127744009987 small, acid-soluble spore protein, SspJ family; Region: spore_sspJ; TIGR02863 1127744009988 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1127744009989 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1127744009990 Sulfatase; Region: Sulfatase; pfam00884 1127744009991 DNA binding domain, excisionase family; Region: excise; TIGR01764 1127744009992 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 1127744009993 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1127744009994 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1127744009995 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1127744009996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744009997 dimer interface [polypeptide binding]; other site 1127744009998 conserved gate region; other site 1127744009999 putative PBP binding loops; other site 1127744010000 ABC-ATPase subunit interface; other site 1127744010001 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1127744010002 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1127744010003 active site 1127744010004 catalytic tetrad [active] 1127744010005 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1127744010006 sulfite reductase subunit beta; Provisional; Region: PRK13504 1127744010007 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1127744010008 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1127744010009 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1127744010010 Flavodoxin; Region: Flavodoxin_1; pfam00258 1127744010011 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1127744010012 FAD binding pocket [chemical binding]; other site 1127744010013 FAD binding motif [chemical binding]; other site 1127744010014 catalytic residues [active] 1127744010015 NAD binding pocket [chemical binding]; other site 1127744010016 phosphate binding motif [ion binding]; other site 1127744010017 beta-alpha-beta structure motif; other site 1127744010018 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1127744010019 Part of AAA domain; Region: AAA_19; pfam13245 1127744010020 Family description; Region: UvrD_C_2; pfam13538 1127744010021 Predicted membrane protein [Function unknown]; Region: COG2860 1127744010022 UPF0126 domain; Region: UPF0126; pfam03458 1127744010023 UPF0126 domain; Region: UPF0126; pfam03458 1127744010024 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1127744010025 Thioredoxin; Region: Thioredoxin_4; pfam13462 1127744010026 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1127744010027 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1127744010028 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1127744010029 metal-binding site [ion binding] 1127744010030 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1127744010031 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1127744010032 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1127744010033 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1127744010034 metal-binding site [ion binding] 1127744010035 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1127744010036 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1127744010037 metal-binding site [ion binding] 1127744010038 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1127744010039 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1127744010040 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1127744010041 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1127744010042 metal-binding site [ion binding] 1127744010043 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 1127744010044 putative homodimer interface [polypeptide binding]; other site 1127744010045 putative homotetramer interface [polypeptide binding]; other site 1127744010046 allosteric switch controlling residues; other site 1127744010047 putative metal binding site [ion binding]; other site 1127744010048 putative homodimer-homodimer interface [polypeptide binding]; other site 1127744010049 putative oxidoreductase; Provisional; Region: PRK11579 1127744010050 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1127744010051 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1127744010052 azoreductase; Reviewed; Region: PRK00170 1127744010053 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1127744010054 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1127744010055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744010056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744010057 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1127744010058 classical (c) SDRs; Region: SDR_c; cd05233 1127744010059 NAD(P) binding site [chemical binding]; other site 1127744010060 active site 1127744010061 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1127744010062 SmpB-tmRNA interface; other site 1127744010063 ribonuclease R; Region: RNase_R; TIGR02063 1127744010064 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1127744010065 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1127744010066 RNB domain; Region: RNB; pfam00773 1127744010067 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1127744010068 RNA binding site [nucleotide binding]; other site 1127744010069 Esterase/lipase [General function prediction only]; Region: COG1647 1127744010070 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1127744010071 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1127744010072 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127744010073 salt bridge; other site 1127744010074 non-specific DNA binding site [nucleotide binding]; other site 1127744010075 sequence-specific DNA binding site [nucleotide binding]; other site 1127744010076 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127744010077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127744010078 non-specific DNA binding site [nucleotide binding]; other site 1127744010079 salt bridge; other site 1127744010080 sequence-specific DNA binding site [nucleotide binding]; other site 1127744010081 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127744010082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127744010083 non-specific DNA binding site [nucleotide binding]; other site 1127744010084 salt bridge; other site 1127744010085 sequence-specific DNA binding site [nucleotide binding]; other site 1127744010086 Predicted transcriptional regulators [Transcription]; Region: COG1733 1127744010087 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1127744010088 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1127744010089 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744010090 dimerization interface [polypeptide binding]; other site 1127744010091 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1127744010092 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1127744010093 dimer interface [polypeptide binding]; other site 1127744010094 putative CheW interface [polypeptide binding]; other site 1127744010095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744010096 dimer interface [polypeptide binding]; other site 1127744010097 conserved gate region; other site 1127744010098 putative PBP binding loops; other site 1127744010099 ABC-ATPase subunit interface; other site 1127744010100 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1127744010101 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1127744010102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744010103 dimer interface [polypeptide binding]; other site 1127744010104 conserved gate region; other site 1127744010105 putative PBP binding loops; other site 1127744010106 ABC-ATPase subunit interface; other site 1127744010107 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1127744010108 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1127744010109 Walker A/P-loop; other site 1127744010110 ATP binding site [chemical binding]; other site 1127744010111 Q-loop/lid; other site 1127744010112 ABC transporter signature motif; other site 1127744010113 Walker B; other site 1127744010114 D-loop; other site 1127744010115 H-loop/switch region; other site 1127744010116 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1127744010117 Predicted transcriptional regulators [Transcription]; Region: COG1510 1127744010118 MarR family; Region: MarR_2; pfam12802 1127744010119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744010120 dimer interface [polypeptide binding]; other site 1127744010121 conserved gate region; other site 1127744010122 putative PBP binding loops; other site 1127744010123 ABC-ATPase subunit interface; other site 1127744010124 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1127744010125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744010126 dimer interface [polypeptide binding]; other site 1127744010127 conserved gate region; other site 1127744010128 putative PBP binding loops; other site 1127744010129 ABC-ATPase subunit interface; other site 1127744010130 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1127744010131 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1127744010132 Walker A/P-loop; other site 1127744010133 ATP binding site [chemical binding]; other site 1127744010134 Q-loop/lid; other site 1127744010135 ABC transporter signature motif; other site 1127744010136 Walker B; other site 1127744010137 D-loop; other site 1127744010138 H-loop/switch region; other site 1127744010139 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1127744010140 Predicted transcriptional regulators [Transcription]; Region: COG1510 1127744010141 MarR family; Region: MarR_2; pfam12802 1127744010142 membrane protein, MarC family; Region: TIGR00427 1127744010143 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1127744010144 Predicted membrane protein [Function unknown]; Region: COG4640 1127744010145 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1127744010146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744010147 Coenzyme A binding pocket [chemical binding]; other site 1127744010148 enolase; Provisional; Region: eno; PRK00077 1127744010149 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1127744010150 dimer interface [polypeptide binding]; other site 1127744010151 metal binding site [ion binding]; metal-binding site 1127744010152 substrate binding pocket [chemical binding]; other site 1127744010153 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1127744010154 phosphoglyceromutase; Provisional; Region: PRK05434 1127744010155 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1127744010156 triosephosphate isomerase; Provisional; Region: PRK14565 1127744010157 substrate binding site [chemical binding]; other site 1127744010158 dimer interface [polypeptide binding]; other site 1127744010159 catalytic triad [active] 1127744010160 Phosphoglycerate kinase; Region: PGK; pfam00162 1127744010161 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1127744010162 substrate binding site [chemical binding]; other site 1127744010163 hinge regions; other site 1127744010164 ADP binding site [chemical binding]; other site 1127744010165 catalytic site [active] 1127744010166 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1127744010167 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1127744010168 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1127744010169 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1127744010170 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1127744010171 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1127744010172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744010173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744010174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744010175 DNA-binding site [nucleotide binding]; DNA binding site 1127744010176 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1127744010177 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1127744010178 putative dimerization interface [polypeptide binding]; other site 1127744010179 putative ligand binding site [chemical binding]; other site 1127744010180 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1127744010181 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127744010182 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1127744010183 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744010184 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744010185 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1127744010186 dimerization interface [polypeptide binding]; other site 1127744010187 EamA-like transporter family; Region: EamA; pfam00892 1127744010188 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1127744010189 EamA-like transporter family; Region: EamA; pfam00892 1127744010190 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1127744010191 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1127744010192 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1127744010193 active site 1127744010194 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1127744010195 iron-sulfur cluster-binding protein; Region: TIGR00273 1127744010196 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1127744010197 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1127744010198 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1127744010199 Cysteine-rich domain; Region: CCG; pfam02754 1127744010200 Cysteine-rich domain; Region: CCG; pfam02754 1127744010201 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127744010202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744010203 active site 1127744010204 phosphorylation site [posttranslational modification] 1127744010205 intermolecular recognition site; other site 1127744010206 dimerization interface [polypeptide binding]; other site 1127744010207 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127744010208 DNA binding residues [nucleotide binding] 1127744010209 dimerization interface [polypeptide binding]; other site 1127744010210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127744010211 Histidine kinase; Region: HisKA_3; pfam07730 1127744010212 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1127744010213 ATP binding site [chemical binding]; other site 1127744010214 Mg2+ binding site [ion binding]; other site 1127744010215 G-X-G motif; other site 1127744010216 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1127744010217 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1127744010218 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1127744010219 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1127744010220 Walker A/P-loop; other site 1127744010221 ATP binding site [chemical binding]; other site 1127744010222 Q-loop/lid; other site 1127744010223 ABC transporter signature motif; other site 1127744010224 Walker B; other site 1127744010225 D-loop; other site 1127744010226 H-loop/switch region; other site 1127744010227 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1127744010228 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1127744010229 catalytic site [active] 1127744010230 PAS domain S-box; Region: sensory_box; TIGR00229 1127744010231 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1127744010232 putative active site [active] 1127744010233 heme pocket [chemical binding]; other site 1127744010234 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1127744010235 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1127744010236 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 1127744010237 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1127744010238 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1127744010239 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1127744010240 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1127744010241 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1127744010242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744010243 dimer interface [polypeptide binding]; other site 1127744010244 conserved gate region; other site 1127744010245 putative PBP binding loops; other site 1127744010246 ABC-ATPase subunit interface; other site 1127744010247 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1127744010248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744010249 dimer interface [polypeptide binding]; other site 1127744010250 conserved gate region; other site 1127744010251 ABC-ATPase subunit interface; other site 1127744010252 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1127744010253 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1127744010254 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1127744010255 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1127744010256 DNA binding site [nucleotide binding] 1127744010257 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1127744010258 putative dimerization interface [polypeptide binding]; other site 1127744010259 putative ligand binding site [chemical binding]; other site 1127744010260 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1127744010261 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744010262 DNA-binding site [nucleotide binding]; DNA binding site 1127744010263 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1127744010264 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1127744010265 L-lactate permease; Region: Lactate_perm; pfam02652 1127744010266 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1127744010267 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1127744010268 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1127744010269 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1127744010270 YvfG protein; Region: YvfG; pfam09628 1127744010271 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1127744010272 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1127744010273 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1127744010274 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1127744010275 inhibitor-cofactor binding pocket; inhibition site 1127744010276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744010277 catalytic residue [active] 1127744010278 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1127744010279 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1127744010280 putative trimer interface [polypeptide binding]; other site 1127744010281 putative CoA binding site [chemical binding]; other site 1127744010282 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1127744010283 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1127744010284 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1127744010285 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1127744010286 active site 1127744010287 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1127744010288 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1127744010289 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1127744010290 active site 1127744010291 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1127744010292 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1127744010293 putative ADP-binding pocket [chemical binding]; other site 1127744010294 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1127744010295 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1127744010296 active site 1127744010297 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1127744010298 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1127744010299 putative ADP-binding pocket [chemical binding]; other site 1127744010300 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1127744010301 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1127744010302 NAD(P) binding site [chemical binding]; other site 1127744010303 homodimer interface [polypeptide binding]; other site 1127744010304 substrate binding site [chemical binding]; other site 1127744010305 active site 1127744010306 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1127744010307 Chain length determinant protein; Region: Wzz; cl15801 1127744010308 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127744010309 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127744010310 non-specific DNA binding site [nucleotide binding]; other site 1127744010311 salt bridge; other site 1127744010312 sequence-specific DNA binding site [nucleotide binding]; other site 1127744010313 Anti-repressor SinI; Region: SinI; pfam08671 1127744010314 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1127744010315 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1127744010316 substrate binding pocket [chemical binding]; other site 1127744010317 catalytic triad [active] 1127744010318 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1127744010319 hypothetical protein; Provisional; Region: PRK00872 1127744010320 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1127744010321 aspartate racemase; Region: asp_race; TIGR00035 1127744010322 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1127744010323 Beta-lactamase; Region: Beta-lactamase; pfam00144 1127744010324 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1127744010325 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1127744010326 active site 1127744010327 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1127744010328 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1127744010329 substrate binding [chemical binding]; other site 1127744010330 active site 1127744010331 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1127744010332 amino acid transporter; Region: 2A0306; TIGR00909 1127744010333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744010334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744010335 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1127744010336 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1127744010337 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1127744010338 Clp protease; Region: CLP_protease; pfam00574 1127744010339 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1127744010340 oligomer interface [polypeptide binding]; other site 1127744010341 active site residues [active] 1127744010342 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1127744010343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744010344 motif II; other site 1127744010345 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1127744010346 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1127744010347 Ca binding site [ion binding]; other site 1127744010348 active site 1127744010349 catalytic site [active] 1127744010350 Predicted integral membrane protein [Function unknown]; Region: COG5521 1127744010351 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1127744010352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744010353 dimer interface [polypeptide binding]; other site 1127744010354 conserved gate region; other site 1127744010355 ABC-ATPase subunit interface; other site 1127744010356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744010357 dimer interface [polypeptide binding]; other site 1127744010358 conserved gate region; other site 1127744010359 putative PBP binding loops; other site 1127744010360 ABC-ATPase subunit interface; other site 1127744010361 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1127744010362 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1127744010363 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1127744010364 homodimer interface [polypeptide binding]; other site 1127744010365 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1127744010366 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1127744010367 active site 1127744010368 homodimer interface [polypeptide binding]; other site 1127744010369 catalytic site [active] 1127744010370 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1127744010371 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1127744010372 DNA binding site [nucleotide binding] 1127744010373 domain linker motif; other site 1127744010374 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1127744010375 ligand binding site [chemical binding]; other site 1127744010376 dimerization interface [polypeptide binding]; other site 1127744010377 TIGR00730 family protein; Region: TIGR00730 1127744010378 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1127744010379 metal binding site [ion binding]; metal-binding site 1127744010380 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1127744010381 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1127744010382 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1127744010383 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1127744010384 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1127744010385 active site clefts [active] 1127744010386 zinc binding site [ion binding]; other site 1127744010387 dimer interface [polypeptide binding]; other site 1127744010388 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1127744010389 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1127744010390 dimerization interface [polypeptide binding]; other site 1127744010391 ligand binding site [chemical binding]; other site 1127744010392 NADP binding site [chemical binding]; other site 1127744010393 catalytic site [active] 1127744010394 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1127744010395 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1127744010396 Walker A/P-loop; other site 1127744010397 ATP binding site [chemical binding]; other site 1127744010398 Q-loop/lid; other site 1127744010399 ABC transporter signature motif; other site 1127744010400 Walker B; other site 1127744010401 D-loop; other site 1127744010402 H-loop/switch region; other site 1127744010403 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1127744010404 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1127744010405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744010406 ATP binding site [chemical binding]; other site 1127744010407 Mg2+ binding site [ion binding]; other site 1127744010408 G-X-G motif; other site 1127744010409 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127744010410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744010411 active site 1127744010412 phosphorylation site [posttranslational modification] 1127744010413 intermolecular recognition site; other site 1127744010414 dimerization interface [polypeptide binding]; other site 1127744010415 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127744010416 DNA binding site [nucleotide binding] 1127744010417 Lysis protein; Region: Lysis_col; pfam02402 1127744010418 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1127744010419 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1127744010420 dimerization domain swap beta strand [polypeptide binding]; other site 1127744010421 regulatory protein interface [polypeptide binding]; other site 1127744010422 active site 1127744010423 regulatory phosphorylation site [posttranslational modification]; other site 1127744010424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1127744010425 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1127744010426 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1127744010427 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1127744010428 phosphate binding site [ion binding]; other site 1127744010429 putative substrate binding pocket [chemical binding]; other site 1127744010430 dimer interface [polypeptide binding]; other site 1127744010431 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1127744010432 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1127744010433 putative active site [active] 1127744010434 nucleotide binding site [chemical binding]; other site 1127744010435 nudix motif; other site 1127744010436 putative metal binding site [ion binding]; other site 1127744010437 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1127744010438 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1127744010439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127744010440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1127744010441 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1127744010442 NlpC/P60 family; Region: NLPC_P60; pfam00877 1127744010443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744010444 binding surface 1127744010445 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1127744010446 TPR motif; other site 1127744010447 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1127744010448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744010449 TPR motif; other site 1127744010450 binding surface 1127744010451 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127744010452 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1127744010453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1127744010454 Walker A/P-loop; other site 1127744010455 ATP binding site [chemical binding]; other site 1127744010456 Q-loop/lid; other site 1127744010457 ABC transporter signature motif; other site 1127744010458 Walker B; other site 1127744010459 D-loop; other site 1127744010460 H-loop/switch region; other site 1127744010461 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1127744010462 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1127744010463 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1127744010464 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1127744010465 metal binding site [ion binding]; metal-binding site 1127744010466 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1127744010467 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1127744010468 substrate binding site [chemical binding]; other site 1127744010469 glutamase interaction surface [polypeptide binding]; other site 1127744010470 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1127744010471 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1127744010472 catalytic residues [active] 1127744010473 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1127744010474 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1127744010475 putative active site [active] 1127744010476 oxyanion strand; other site 1127744010477 catalytic triad [active] 1127744010478 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1127744010479 putative active site pocket [active] 1127744010480 4-fold oligomerization interface [polypeptide binding]; other site 1127744010481 metal binding residues [ion binding]; metal-binding site 1127744010482 3-fold/trimer interface [polypeptide binding]; other site 1127744010483 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1127744010484 histidinol dehydrogenase; Region: hisD; TIGR00069 1127744010485 NAD binding site [chemical binding]; other site 1127744010486 dimerization interface [polypeptide binding]; other site 1127744010487 product binding site; other site 1127744010488 substrate binding site [chemical binding]; other site 1127744010489 zinc binding site [ion binding]; other site 1127744010490 catalytic residues [active] 1127744010491 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1127744010492 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1127744010493 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1127744010494 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1127744010495 dimer interface [polypeptide binding]; other site 1127744010496 motif 1; other site 1127744010497 active site 1127744010498 motif 2; other site 1127744010499 motif 3; other site 1127744010500 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1127744010501 putative active site [active] 1127744010502 Pectate lyase; Region: Pectate_lyase; pfam03211 1127744010503 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1127744010504 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1127744010505 CoA binding site [chemical binding]; other site 1127744010506 active site 1127744010507 pyrophosphatase PpaX; Provisional; Region: PRK13288 1127744010508 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1127744010509 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744010510 motif II; other site 1127744010511 Nucleoside recognition; Region: Gate; pfam07670 1127744010512 Nucleoside recognition; Region: Gate; pfam07670 1127744010513 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1127744010514 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1127744010515 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1127744010516 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1127744010517 Hpr binding site; other site 1127744010518 active site 1127744010519 homohexamer subunit interaction site [polypeptide binding]; other site 1127744010520 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1127744010521 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1127744010522 active site 1127744010523 dimer interface [polypeptide binding]; other site 1127744010524 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1127744010525 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1127744010526 active site 1127744010527 trimer interface [polypeptide binding]; other site 1127744010528 allosteric site; other site 1127744010529 active site lid [active] 1127744010530 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1127744010531 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1127744010532 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744010533 DNA-binding site [nucleotide binding]; DNA binding site 1127744010534 UTRA domain; Region: UTRA; pfam07702 1127744010535 Lamin Tail Domain; Region: LTD; pfam00932 1127744010536 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1127744010537 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1127744010538 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1127744010539 putative active site [active] 1127744010540 putative metal binding site [ion binding]; other site 1127744010541 Predicted membrane protein [Function unknown]; Region: COG1950 1127744010542 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1127744010543 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1127744010544 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1127744010545 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1127744010546 flagellin; Provisional; Region: PRK12804 1127744010547 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1127744010548 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1127744010549 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1127744010550 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1127744010551 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1127744010552 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1127744010553 excinuclease ABC subunit B; Provisional; Region: PRK05298 1127744010554 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127744010555 ATP binding site [chemical binding]; other site 1127744010556 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127744010557 nucleotide binding region [chemical binding]; other site 1127744010558 ATP-binding site [chemical binding]; other site 1127744010559 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1127744010560 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 1127744010561 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1127744010562 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1127744010563 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1127744010564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744010565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744010566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744010567 putative substrate translocation pore; other site 1127744010568 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1127744010569 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1127744010570 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1127744010571 C-terminal peptidase (prc); Region: prc; TIGR00225 1127744010572 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1127744010573 protein binding site [polypeptide binding]; other site 1127744010574 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1127744010575 Catalytic dyad [active] 1127744010576 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1127744010577 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1127744010578 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1127744010579 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1127744010580 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 1127744010581 Walker A/P-loop; other site 1127744010582 ATP binding site [chemical binding]; other site 1127744010583 Q-loop/lid; other site 1127744010584 ABC transporter signature motif; other site 1127744010585 Walker B; other site 1127744010586 D-loop; other site 1127744010587 H-loop/switch region; other site 1127744010588 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1127744010589 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1127744010590 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1127744010591 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127744010592 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127744010593 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1127744010594 peptide chain release factor 2; Provisional; Region: PRK06746 1127744010595 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1127744010596 RF-1 domain; Region: RF-1; pfam00472 1127744010597 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1127744010598 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1127744010599 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1127744010600 nucleotide binding region [chemical binding]; other site 1127744010601 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1127744010602 ATP-binding site [chemical binding]; other site 1127744010603 SEC-C motif; Region: SEC-C; pfam02810 1127744010604 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1127744010605 30S subunit binding site; other site 1127744010606 Flagellar protein FliT; Region: FliT; pfam05400 1127744010607 flagellar biosynthetic protein FliS; Region: fliS; TIGR00208 1127744010608 flagellar capping protein; Validated; Region: fliD; PRK07737 1127744010609 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1127744010610 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1127744010611 flagellar protein FlaG; Provisional; Region: PRK07738 1127744010612 flagellin; Provisional; Region: PRK12804 1127744010613 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1127744010614 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1127744010615 carbon storage regulator; Provisional; Region: PRK01712 1127744010616 flagellar assembly protein FliW; Provisional; Region: PRK13285 1127744010617 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1127744010618 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1127744010619 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1127744010620 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1127744010621 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1127744010622 FlgN protein; Region: FlgN; pfam05130 1127744010623 Negative regulator of flagellin synthesis (anti-sigma28 factor) [Transcription / Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgM; COG2747 1127744010624 flagellar operon protein TIGR03826; Region: YvyF 1127744010625 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127744010626 active site 1127744010627 Late competence development protein ComFB; Region: ComFB; pfam10719 1127744010628 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1127744010629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127744010630 ATP binding site [chemical binding]; other site 1127744010631 putative Mg++ binding site [ion binding]; other site 1127744010632 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127744010633 nucleotide binding region [chemical binding]; other site 1127744010634 ATP-binding site [chemical binding]; other site 1127744010635 EDD domain protein, DegV family; Region: DegV; TIGR00762 1127744010636 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1127744010637 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127744010638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744010639 active site 1127744010640 phosphorylation site [posttranslational modification] 1127744010641 intermolecular recognition site; other site 1127744010642 dimerization interface [polypeptide binding]; other site 1127744010643 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127744010644 DNA binding residues [nucleotide binding] 1127744010645 dimerization interface [polypeptide binding]; other site 1127744010646 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127744010647 Histidine kinase; Region: HisKA_3; pfam07730 1127744010648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744010649 ATP binding site [chemical binding]; other site 1127744010650 Mg2+ binding site [ion binding]; other site 1127744010651 G-X-G motif; other site 1127744010652 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1127744010653 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1127744010654 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1127744010655 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1127744010656 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1127744010657 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1127744010658 Mg++ binding site [ion binding]; other site 1127744010659 putative catalytic motif [active] 1127744010660 substrate binding site [chemical binding]; other site 1127744010661 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1127744010662 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1127744010663 putative homodimer interface [polypeptide binding]; other site 1127744010664 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1127744010665 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1127744010666 active site 1127744010667 Chain length determinant protein; Region: Wzz; cl15801 1127744010668 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1127744010669 O-Antigen ligase; Region: Wzy_C; pfam04932 1127744010670 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1127744010671 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1127744010672 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1127744010673 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1127744010674 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1127744010675 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1127744010676 colanic acid exporter; Provisional; Region: PRK10459 1127744010677 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1127744010678 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1127744010679 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1127744010680 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1127744010681 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1127744010682 active site 1127744010683 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1127744010684 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1127744010685 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1127744010686 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1127744010687 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1127744010688 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1127744010689 active site 1127744010690 metal binding site [ion binding]; metal-binding site 1127744010691 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1127744010692 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1127744010693 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1127744010694 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1127744010695 Stage II sporulation protein; Region: SpoIID; pfam08486 1127744010696 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1127744010697 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 1127744010698 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1127744010699 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1127744010700 active site 1127744010701 homodimer interface [polypeptide binding]; other site 1127744010702 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1127744010703 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1127744010704 active site 1127744010705 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1127744010706 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1127744010707 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1127744010708 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1127744010709 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1127744010710 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1127744010711 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1127744010712 active site 1127744010713 tetramer interface; other site 1127744010714 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1127744010715 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1127744010716 Walker A/P-loop; other site 1127744010717 ATP binding site [chemical binding]; other site 1127744010718 Q-loop/lid; other site 1127744010719 ABC transporter signature motif; other site 1127744010720 Walker B; other site 1127744010721 D-loop; other site 1127744010722 H-loop/switch region; other site 1127744010723 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1127744010724 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1127744010725 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1127744010726 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1127744010727 putative ADP-binding pocket [chemical binding]; other site 1127744010728 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1127744010729 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1127744010730 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1127744010731 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1127744010732 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1127744010733 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1127744010734 active site 1127744010735 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1127744010736 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1127744010737 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1127744010738 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1127744010739 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1127744010740 substrate binding site; other site 1127744010741 dimer interface; other site 1127744010742 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1127744010743 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1127744010744 putative NAD(P) binding site [chemical binding]; other site 1127744010745 putative catalytic Zn binding site [ion binding]; other site 1127744010746 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1127744010747 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1127744010748 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1127744010749 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1127744010750 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1127744010751 Bacterial SH3 domain; Region: SH3_3; pfam08239 1127744010752 Lysozyme subfamily 2; Region: LYZ2; smart00047 1127744010753 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1127744010754 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1127744010755 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1127744010756 Spore germination protein; Region: Spore_permease; pfam03845 1127744010757 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1127744010758 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1127744010759 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1127744010760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744010761 putative substrate translocation pore; other site 1127744010762 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1127744010763 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744010764 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1127744010765 active site 1127744010766 motif I; other site 1127744010767 motif II; other site 1127744010768 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1127744010769 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1127744010770 NlpC/P60 family; Region: NLPC_P60; pfam00877 1127744010771 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1127744010772 NlpC/P60 family; Region: NLPC_P60; pfam00877 1127744010773 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1127744010774 NlpC/P60 family; Region: NLPC_P60; pfam00877 1127744010775 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1127744010776 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1127744010777 putative active site [active] 1127744010778 putative metal binding site [ion binding]; other site 1127744010779 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 1127744010780 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1127744010781 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1127744010782 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1127744010783 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1127744010784 DNA binding site [nucleotide binding] 1127744010785 domain linker motif; other site 1127744010786 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1127744010787 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1127744010788 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1127744010789 substrate binding site [chemical binding]; other site 1127744010790 dimer interface [polypeptide binding]; other site 1127744010791 ATP binding site [chemical binding]; other site 1127744010792 D-ribose pyranase; Provisional; Region: PRK11797 1127744010793 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1127744010794 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1127744010795 Walker A/P-loop; other site 1127744010796 ATP binding site [chemical binding]; other site 1127744010797 Q-loop/lid; other site 1127744010798 ABC transporter signature motif; other site 1127744010799 Walker B; other site 1127744010800 D-loop; other site 1127744010801 H-loop/switch region; other site 1127744010802 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1127744010803 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1127744010804 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1127744010805 TM-ABC transporter signature motif; other site 1127744010806 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1127744010807 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1127744010808 ligand binding site [chemical binding]; other site 1127744010809 dimerization interface [polypeptide binding]; other site 1127744010810 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1127744010811 Bacterial SH3 domain; Region: SH3_3; cl17532 1127744010812 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1127744010813 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1127744010814 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1127744010815 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1127744010816 acetolactate synthase; Reviewed; Region: PRK08617 1127744010817 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1127744010818 PYR/PP interface [polypeptide binding]; other site 1127744010819 dimer interface [polypeptide binding]; other site 1127744010820 TPP binding site [chemical binding]; other site 1127744010821 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1127744010822 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1127744010823 TPP-binding site [chemical binding]; other site 1127744010824 dimer interface [polypeptide binding]; other site 1127744010825 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1127744010826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744010827 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1127744010828 putative dimerization interface [polypeptide binding]; other site 1127744010829 putative substrate binding pocket [chemical binding]; other site 1127744010830 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1127744010831 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1127744010832 transmembrane helices; other site 1127744010833 CotH protein; Region: CotH; pfam08757 1127744010834 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1127744010835 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1127744010836 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1127744010837 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1127744010838 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1127744010839 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127744010840 putative DNA binding site [nucleotide binding]; other site 1127744010841 putative Zn2+ binding site [ion binding]; other site 1127744010842 AsnC family; Region: AsnC_trans_reg; pfam01037 1127744010843 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1127744010844 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1127744010845 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1127744010846 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1127744010847 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744010848 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744010849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1127744010850 dimerization interface [polypeptide binding]; other site 1127744010851 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1127744010852 Active_site [active] 1127744010853 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 1127744010854 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1127744010855 LXG domain of WXG superfamily; Region: LXG; pfam04740 1127744010856 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1127744010857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1127744010858 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1127744010859 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1127744010860 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1127744010861 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1127744010862 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1127744010863 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1127744010864 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1127744010865 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1127744010866 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1127744010867 Chain length determinant protein; Region: Wzz; cl15801 1127744010868 SWIM zinc finger; Region: SWIM; pfam04434 1127744010869 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1127744010870 SNF2 Helicase protein; Region: DUF3670; pfam12419 1127744010871 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127744010872 ATP binding site [chemical binding]; other site 1127744010873 putative Mg++ binding site [ion binding]; other site 1127744010874 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127744010875 nucleotide binding region [chemical binding]; other site 1127744010876 ATP-binding site [chemical binding]; other site 1127744010877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744010878 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1127744010879 active site 1127744010880 motif I; other site 1127744010881 motif II; other site 1127744010882 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744010883 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1127744010884 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1127744010885 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1127744010886 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1127744010887 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1127744010888 dimer interface [polypeptide binding]; other site 1127744010889 ssDNA binding site [nucleotide binding]; other site 1127744010890 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1127744010891 YwpF-like protein; Region: YwpF; pfam14183 1127744010892 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1127744010893 active site 1127744010894 catalytic site [active] 1127744010895 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1127744010896 Collagen binding domain; Region: Collagen_bind; pfam05737 1127744010897 Collagen binding domain; Region: Collagen_bind; pfam05737 1127744010898 Collagen binding domain; Region: Collagen_bind; pfam05737 1127744010899 Collagen binding domain; Region: Collagen_bind; pfam05737 1127744010900 Cna protein B-type domain; Region: Cna_B; pfam05738 1127744010901 Cna protein B-type domain; Region: Cna_B; pfam05738 1127744010902 Cna protein B-type domain; Region: Cna_B; pfam05738 1127744010903 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1127744010904 Cna protein B-type domain; Region: Cna_B; pfam05738 1127744010905 Cna protein B-type domain; Region: Cna_B; pfam05738 1127744010906 Cna protein B-type domain; Region: Cna_B; pfam05738 1127744010907 Cna protein B-type domain; Region: Cna_B; pfam05738 1127744010908 Cna protein B-type domain; Region: Cna_B; pfam05738 1127744010909 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1127744010910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744010911 active site 1127744010912 phosphorylation site [posttranslational modification] 1127744010913 intermolecular recognition site; other site 1127744010914 dimerization interface [polypeptide binding]; other site 1127744010915 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1127744010916 DNA binding site [nucleotide binding] 1127744010917 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1127744010918 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1127744010919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744010920 dimer interface [polypeptide binding]; other site 1127744010921 phosphorylation site [posttranslational modification] 1127744010922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744010923 ATP binding site [chemical binding]; other site 1127744010924 Mg2+ binding site [ion binding]; other site 1127744010925 G-X-G motif; other site 1127744010926 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1127744010927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744010928 active site 1127744010929 phosphorylation site [posttranslational modification] 1127744010930 intermolecular recognition site; other site 1127744010931 dimerization interface [polypeptide binding]; other site 1127744010932 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1127744010933 Histidine kinase; Region: His_kinase; pfam06580 1127744010934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744010935 ATP binding site [chemical binding]; other site 1127744010936 Mg2+ binding site [ion binding]; other site 1127744010937 G-X-G motif; other site 1127744010938 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1127744010939 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1127744010940 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1127744010941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744010942 binding surface 1127744010943 TPR motif; other site 1127744010944 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744010945 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1127744010946 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1127744010947 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1127744010948 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1127744010949 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1127744010950 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1127744010951 MreB and similar proteins; Region: MreB_like; cd10225 1127744010952 nucleotide binding site [chemical binding]; other site 1127744010953 Mg binding site [ion binding]; other site 1127744010954 putative protofilament interaction site [polypeptide binding]; other site 1127744010955 RodZ interaction site [polypeptide binding]; other site 1127744010956 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1127744010957 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744010958 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1127744010959 putative Zn2+ binding site [ion binding]; other site 1127744010960 putative DNA binding site [nucleotide binding]; other site 1127744010961 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744010962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744010963 putative substrate translocation pore; other site 1127744010964 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 1127744010965 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1127744010966 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1127744010967 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1127744010968 Na binding site [ion binding]; other site 1127744010969 putative substrate binding site [chemical binding]; other site 1127744010970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744010971 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744010972 putative substrate translocation pore; other site 1127744010973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744010974 Isochorismatase family; Region: Isochorismatase; pfam00857 1127744010975 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1127744010976 catalytic triad [active] 1127744010977 conserved cis-peptide bond; other site 1127744010978 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1127744010979 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1127744010980 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1127744010981 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1127744010982 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1127744010983 active site 1127744010984 VanZ like family; Region: VanZ; pfam04892 1127744010985 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1127744010986 Peptidase family M23; Region: Peptidase_M23; pfam01551 1127744010987 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1127744010988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744010989 Coenzyme A binding pocket [chemical binding]; other site 1127744010990 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1127744010991 NeuB family; Region: NeuB; pfam03102 1127744010992 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1127744010993 NeuB binding interface [polypeptide binding]; other site 1127744010994 putative substrate binding site [chemical binding]; other site 1127744010995 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1127744010996 ligand binding site; other site 1127744010997 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1127744010998 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1127744010999 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1127744011000 putative active site [active] 1127744011001 catalytic site [active] 1127744011002 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1127744011003 putative active site [active] 1127744011004 catalytic site [active] 1127744011005 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1127744011006 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1127744011007 DNA binding residues [nucleotide binding] 1127744011008 dimer interface [polypeptide binding]; other site 1127744011009 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1127744011010 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1127744011011 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1127744011012 NAD binding site [chemical binding]; other site 1127744011013 substrate binding site [chemical binding]; other site 1127744011014 putative active site [active] 1127744011015 Predicted transcriptional regulator [Transcription]; Region: COG1959 1127744011016 Transcriptional regulator; Region: Rrf2; pfam02082 1127744011017 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1127744011018 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1127744011019 subunit interactions [polypeptide binding]; other site 1127744011020 active site 1127744011021 flap region; other site 1127744011022 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1127744011023 gamma-beta subunit interface [polypeptide binding]; other site 1127744011024 alpha-beta subunit interface [polypeptide binding]; other site 1127744011025 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1127744011026 alpha-gamma subunit interface [polypeptide binding]; other site 1127744011027 beta-gamma subunit interface [polypeptide binding]; other site 1127744011028 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1127744011029 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1127744011030 Walker A/P-loop; other site 1127744011031 ATP binding site [chemical binding]; other site 1127744011032 Q-loop/lid; other site 1127744011033 ABC transporter signature motif; other site 1127744011034 Walker B; other site 1127744011035 D-loop; other site 1127744011036 H-loop/switch region; other site 1127744011037 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1127744011038 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1127744011039 Walker A/P-loop; other site 1127744011040 ATP binding site [chemical binding]; other site 1127744011041 Q-loop/lid; other site 1127744011042 ABC transporter signature motif; other site 1127744011043 Walker B; other site 1127744011044 D-loop; other site 1127744011045 H-loop/switch region; other site 1127744011046 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1127744011047 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1127744011048 TM-ABC transporter signature motif; other site 1127744011049 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1127744011050 TM-ABC transporter signature motif; other site 1127744011051 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1127744011052 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1127744011053 putative ligand binding site [chemical binding]; other site 1127744011054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744011055 binding surface 1127744011056 TPR motif; other site 1127744011057 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744011058 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1127744011059 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127744011060 FeS/SAM binding site; other site 1127744011061 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1127744011062 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1127744011063 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1127744011064 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1127744011065 metal ion-dependent adhesion site (MIDAS); other site 1127744011066 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1127744011067 metal ion-dependent adhesion site (MIDAS); other site 1127744011068 stage II sporulation protein D; Region: spore_II_D; TIGR02870 1127744011069 Stage II sporulation protein; Region: SpoIID; pfam08486 1127744011070 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1127744011071 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1127744011072 hinge; other site 1127744011073 active site 1127744011074 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1127744011075 Predicted membrane protein [Function unknown]; Region: COG4836 1127744011076 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1127744011077 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1127744011078 gamma subunit interface [polypeptide binding]; other site 1127744011079 epsilon subunit interface [polypeptide binding]; other site 1127744011080 LBP interface [polypeptide binding]; other site 1127744011081 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1127744011082 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1127744011083 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1127744011084 alpha subunit interaction interface [polypeptide binding]; other site 1127744011085 Walker A motif; other site 1127744011086 ATP binding site [chemical binding]; other site 1127744011087 Walker B motif; other site 1127744011088 inhibitor binding site; inhibition site 1127744011089 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1127744011090 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1127744011091 core domain interface [polypeptide binding]; other site 1127744011092 delta subunit interface [polypeptide binding]; other site 1127744011093 epsilon subunit interface [polypeptide binding]; other site 1127744011094 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1127744011095 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1127744011096 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1127744011097 beta subunit interaction interface [polypeptide binding]; other site 1127744011098 Walker A motif; other site 1127744011099 ATP binding site [chemical binding]; other site 1127744011100 Walker B motif; other site 1127744011101 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1127744011102 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 1127744011103 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1127744011104 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1127744011105 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1127744011106 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1127744011107 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1127744011108 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1127744011109 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1127744011110 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1127744011111 active site 1127744011112 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1127744011113 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1127744011114 dimer interface [polypeptide binding]; other site 1127744011115 active site 1127744011116 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1127744011117 folate binding site [chemical binding]; other site 1127744011118 hypothetical protein; Provisional; Region: PRK13690 1127744011119 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1127744011120 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1127744011121 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1127744011122 Predicted membrane protein [Function unknown]; Region: COG1971 1127744011123 Domain of unknown function DUF; Region: DUF204; pfam02659 1127744011124 Domain of unknown function DUF; Region: DUF204; pfam02659 1127744011125 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1127744011126 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1127744011127 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1127744011128 stage II sporulation protein R; Region: spore_II_R; TIGR02837 1127744011129 HemK family putative methylases; Region: hemK_fam; TIGR00536 1127744011130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744011131 S-adenosylmethionine binding site [chemical binding]; other site 1127744011132 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1127744011133 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1127744011134 RF-1 domain; Region: RF-1; pfam00472 1127744011135 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1127744011136 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127744011137 putative metal binding site [ion binding]; other site 1127744011138 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1127744011139 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1127744011140 DNA binding residues [nucleotide binding] 1127744011141 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1127744011142 malate dehydrogenase; Provisional; Region: PRK13529 1127744011143 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1127744011144 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1127744011145 NAD(P) binding site [chemical binding]; other site 1127744011146 thymidine kinase; Provisional; Region: PRK04296 1127744011147 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1127744011148 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1127744011149 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1127744011150 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1127744011151 RNA binding site [nucleotide binding]; other site 1127744011152 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1127744011153 multimer interface [polypeptide binding]; other site 1127744011154 Walker A motif; other site 1127744011155 ATP binding site [chemical binding]; other site 1127744011156 Walker B motif; other site 1127744011157 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1127744011158 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1127744011159 putative active site [active] 1127744011160 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1127744011161 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1127744011162 hinge; other site 1127744011163 active site 1127744011164 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1127744011165 active site 1127744011166 intersubunit interactions; other site 1127744011167 catalytic residue [active] 1127744011168 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1127744011169 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1127744011170 intersubunit interface [polypeptide binding]; other site 1127744011171 active site 1127744011172 zinc binding site [ion binding]; other site 1127744011173 Na+ binding site [ion binding]; other site 1127744011174 Response regulator receiver domain; Region: Response_reg; pfam00072 1127744011175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744011176 active site 1127744011177 phosphorylation site [posttranslational modification] 1127744011178 intermolecular recognition site; other site 1127744011179 dimerization interface [polypeptide binding]; other site 1127744011180 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1127744011181 CTP synthetase; Validated; Region: pyrG; PRK05380 1127744011182 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1127744011183 Catalytic site [active] 1127744011184 active site 1127744011185 UTP binding site [chemical binding]; other site 1127744011186 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1127744011187 active site 1127744011188 putative oxyanion hole; other site 1127744011189 catalytic triad [active] 1127744011190 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1127744011191 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1127744011192 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1127744011193 FAD binding site [chemical binding]; other site 1127744011194 homotetramer interface [polypeptide binding]; other site 1127744011195 substrate binding pocket [chemical binding]; other site 1127744011196 catalytic base [active] 1127744011197 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1127744011198 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1127744011199 Cysteine-rich domain; Region: CCG; pfam02754 1127744011200 Cysteine-rich domain; Region: CCG; pfam02754 1127744011201 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1127744011202 PLD-like domain; Region: PLDc_2; pfam13091 1127744011203 putative active site [active] 1127744011204 catalytic site [active] 1127744011205 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1127744011206 PLD-like domain; Region: PLDc_2; pfam13091 1127744011207 putative active site [active] 1127744011208 catalytic site [active] 1127744011209 UV-endonuclease UvdE; Region: UvdE; cl10036 1127744011210 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1127744011211 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1127744011212 folate binding site [chemical binding]; other site 1127744011213 NADP+ binding site [chemical binding]; other site 1127744011214 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1127744011215 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1127744011216 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1127744011217 Walker A/P-loop; other site 1127744011218 ATP binding site [chemical binding]; other site 1127744011219 Q-loop/lid; other site 1127744011220 ABC transporter signature motif; other site 1127744011221 Walker B; other site 1127744011222 D-loop; other site 1127744011223 H-loop/switch region; other site 1127744011224 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1127744011225 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1127744011226 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1127744011227 putative active site [active] 1127744011228 catalytic site [active] 1127744011229 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1127744011230 putative active site [active] 1127744011231 catalytic site [active] 1127744011232 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1127744011233 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127744011234 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1127744011235 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1127744011236 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1127744011237 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1127744011238 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1127744011239 [4Fe-4S] binding site [ion binding]; other site 1127744011240 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1127744011241 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1127744011242 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1127744011243 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1127744011244 molybdopterin cofactor binding site; other site 1127744011245 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1127744011246 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1127744011247 ligand binding site [chemical binding]; other site 1127744011248 flexible hinge region; other site 1127744011249 YwiC-like protein; Region: YwiC; pfam14256 1127744011250 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1127744011251 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1127744011252 ligand binding site [chemical binding]; other site 1127744011253 flexible hinge region; other site 1127744011254 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1127744011255 putative switch regulator; other site 1127744011256 non-specific DNA interactions [nucleotide binding]; other site 1127744011257 DNA binding site [nucleotide binding] 1127744011258 sequence specific DNA binding site [nucleotide binding]; other site 1127744011259 putative cAMP binding site [chemical binding]; other site 1127744011260 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1127744011261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744011262 putative substrate translocation pore; other site 1127744011263 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1127744011264 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1127744011265 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1127744011266 active site 1127744011267 HIGH motif; other site 1127744011268 KMSK motif region; other site 1127744011269 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1127744011270 tRNA binding surface [nucleotide binding]; other site 1127744011271 anticodon binding site; other site 1127744011272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 1127744011273 Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420 1127744011274 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1127744011275 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1127744011276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1127744011277 FeS/SAM binding site; other site 1127744011278 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1127744011279 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1127744011280 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1127744011281 Walker A/P-loop; other site 1127744011282 ATP binding site [chemical binding]; other site 1127744011283 Q-loop/lid; other site 1127744011284 ABC transporter signature motif; other site 1127744011285 Walker B; other site 1127744011286 D-loop; other site 1127744011287 H-loop/switch region; other site 1127744011288 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1127744011289 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1127744011290 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1127744011291 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1127744011292 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1127744011293 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1127744011294 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1127744011295 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1127744011296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744011297 binding surface 1127744011298 TPR motif; other site 1127744011299 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744011300 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744011301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1127744011302 TPR motif; other site 1127744011303 binding surface 1127744011304 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1127744011305 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1127744011306 putative deacylase active site [active] 1127744011307 agmatinase; Region: agmatinase; TIGR01230 1127744011308 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1127744011309 putative active site [active] 1127744011310 Mn binding site [ion binding]; other site 1127744011311 spermidine synthase; Provisional; Region: PRK00811 1127744011312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744011313 Transglycosylase; Region: Transgly; pfam00912 1127744011314 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1127744011315 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1127744011316 YwhD family; Region: YwhD; pfam08741 1127744011317 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1127744011318 Peptidase family M50; Region: Peptidase_M50; pfam02163 1127744011319 active site 1127744011320 putative substrate binding region [chemical binding]; other site 1127744011321 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1127744011322 active site 1 [active] 1127744011323 dimer interface [polypeptide binding]; other site 1127744011324 hexamer interface [polypeptide binding]; other site 1127744011325 active site 2 [active] 1127744011326 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744011327 MarR family; Region: MarR; pfam01047 1127744011328 MarR family; Region: MarR_2; cl17246 1127744011329 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 1127744011330 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1127744011331 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1127744011332 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1127744011333 active site 1127744011334 dimer interface [polypeptide binding]; other site 1127744011335 motif 1; other site 1127744011336 motif 2; other site 1127744011337 motif 3; other site 1127744011338 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1127744011339 anticodon binding site; other site 1127744011340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744011341 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744011342 putative substrate translocation pore; other site 1127744011343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744011344 putative substrate translocation pore; other site 1127744011345 Rrf2 family protein; Region: rrf2_super; TIGR00738 1127744011346 Transcriptional regulator; Region: Rrf2; pfam02082 1127744011347 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1127744011348 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1127744011349 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1127744011350 Zn2+ binding site [ion binding]; other site 1127744011351 Mg2+ binding site [ion binding]; other site 1127744011352 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1127744011353 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1127744011354 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1127744011355 EamA-like transporter family; Region: EamA; pfam00892 1127744011356 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1127744011357 EamA-like transporter family; Region: EamA; pfam00892 1127744011358 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1127744011359 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744011360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744011361 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1127744011362 putative dimerization interface [polypeptide binding]; other site 1127744011363 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1127744011364 putative heme peroxidase; Provisional; Region: PRK12276 1127744011365 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1127744011366 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1127744011367 putative NAD(P) binding site [chemical binding]; other site 1127744011368 putative active site [active] 1127744011369 transaminase; Reviewed; Region: PRK08068 1127744011370 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1127744011371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744011372 homodimer interface [polypeptide binding]; other site 1127744011373 catalytic residue [active] 1127744011374 H+ Antiporter protein; Region: 2A0121; TIGR00900 1127744011375 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1127744011376 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1127744011377 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1127744011378 classical (c) SDRs; Region: SDR_c; cd05233 1127744011379 NAD(P) binding site [chemical binding]; other site 1127744011380 active site 1127744011381 Cupin domain; Region: Cupin_2; pfam07883 1127744011382 Cupin domain; Region: Cupin_2; pfam07883 1127744011383 Prephenate dehydratase; Region: PDT; pfam00800 1127744011384 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1127744011385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744011386 putative substrate translocation pore; other site 1127744011387 S-methylmethionine transporter; Provisional; Region: PRK11387 1127744011388 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1127744011389 putative metal binding site [ion binding]; other site 1127744011390 putative dimer interface [polypeptide binding]; other site 1127744011391 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1127744011392 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1127744011393 Glutamate binding site [chemical binding]; other site 1127744011394 homodimer interface [polypeptide binding]; other site 1127744011395 NAD binding site [chemical binding]; other site 1127744011396 catalytic residues [active] 1127744011397 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1127744011398 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1127744011399 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1127744011400 NAD(P) binding site [chemical binding]; other site 1127744011401 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1127744011402 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1127744011403 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 1127744011404 NAD binding site [chemical binding]; other site 1127744011405 substrate binding site [chemical binding]; other site 1127744011406 homodimer interface [polypeptide binding]; other site 1127744011407 active site 1127744011408 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1127744011409 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1127744011410 substrate binding site; other site 1127744011411 tetramer interface; other site 1127744011412 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1127744011413 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1127744011414 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1127744011415 ligand binding site; other site 1127744011416 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1127744011417 NeuB family; Region: NeuB; pfam03102 1127744011418 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1127744011419 NeuB binding interface [polypeptide binding]; other site 1127744011420 putative substrate binding site [chemical binding]; other site 1127744011421 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1127744011422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744011423 Coenzyme A binding pocket [chemical binding]; other site 1127744011424 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1127744011425 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1127744011426 inhibitor-cofactor binding pocket; inhibition site 1127744011427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744011428 catalytic residue [active] 1127744011429 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1127744011430 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1127744011431 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1127744011432 active site 1127744011433 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1127744011434 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1127744011435 Permease family; Region: Xan_ur_permease; pfam00860 1127744011436 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1127744011437 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1127744011438 NAD(P) binding site [chemical binding]; other site 1127744011439 catalytic residues [active] 1127744011440 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1127744011441 ligand binding site [chemical binding]; other site 1127744011442 active site 1127744011443 UGI interface [polypeptide binding]; other site 1127744011444 catalytic site [active] 1127744011445 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1127744011446 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1127744011447 active site 1127744011448 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1127744011449 dimer interface [polypeptide binding]; other site 1127744011450 substrate binding site [chemical binding]; other site 1127744011451 ATP binding site [chemical binding]; other site 1127744011452 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1127744011453 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1127744011454 substrate binding [chemical binding]; other site 1127744011455 active site 1127744011456 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1127744011457 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1127744011458 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1127744011459 active site turn [active] 1127744011460 phosphorylation site [posttranslational modification] 1127744011461 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1127744011462 formate/nitrite transporter; Region: fnt; TIGR00790 1127744011463 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1127744011464 CAT RNA binding domain; Region: CAT_RBD; smart01061 1127744011465 PRD domain; Region: PRD; pfam00874 1127744011466 PRD domain; Region: PRD; pfam00874 1127744011467 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1127744011468 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1127744011469 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1127744011470 putative active site [active] 1127744011471 catalytic triad [active] 1127744011472 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1127744011473 PA/protease domain interface [polypeptide binding]; other site 1127744011474 putative integrin binding motif; other site 1127744011475 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1127744011476 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1127744011477 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1127744011478 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1127744011479 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1127744011480 dimer interface [polypeptide binding]; other site 1127744011481 FMN binding site [chemical binding]; other site 1127744011482 NADPH bind site [chemical binding]; other site 1127744011483 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1127744011484 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1127744011485 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1127744011486 Subunit I/III interface [polypeptide binding]; other site 1127744011487 Subunit III/IV interface [polypeptide binding]; other site 1127744011488 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1127744011489 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1127744011490 D-pathway; other site 1127744011491 Putative ubiquinol binding site [chemical binding]; other site 1127744011492 Low-spin heme (heme b) binding site [chemical binding]; other site 1127744011493 Putative water exit pathway; other site 1127744011494 Binuclear center (heme o3/CuB) [ion binding]; other site 1127744011495 K-pathway; other site 1127744011496 Putative proton exit pathway; other site 1127744011497 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1127744011498 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1127744011499 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1127744011500 Predicted membrane protein [Function unknown]; Region: COG2261 1127744011501 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 1127744011502 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1127744011503 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1127744011504 galactokinase; Provisional; Region: PRK05322 1127744011505 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1127744011506 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1127744011507 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1127744011508 Predicted membrane protein [Function unknown]; Region: COG2246 1127744011509 GtrA-like protein; Region: GtrA; pfam04138 1127744011510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744011511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744011512 Anti-repressor SinI; Region: SinI; pfam08671 1127744011513 Predicted membrane protein [Function unknown]; Region: COG3162 1127744011514 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1127744011515 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1127744011516 Na binding site [ion binding]; other site 1127744011517 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1127744011518 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1127744011519 catalytic residues [active] 1127744011520 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1127744011521 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1127744011522 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1127744011523 Imelysin; Region: Peptidase_M75; pfam09375 1127744011524 FTR1 family protein; Region: TIGR00145 1127744011525 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1127744011526 thiamine phosphate binding site [chemical binding]; other site 1127744011527 active site 1127744011528 pyrophosphate binding site [ion binding]; other site 1127744011529 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1127744011530 substrate binding site [chemical binding]; other site 1127744011531 multimerization interface [polypeptide binding]; other site 1127744011532 ATP binding site [chemical binding]; other site 1127744011533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744011534 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744011535 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1127744011536 putative dimerization interface [polypeptide binding]; other site 1127744011537 holin-like protein; Validated; Region: PRK01658 1127744011538 TIGR00659 family protein; Region: TIGR00659 1127744011539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1127744011540 Walker A/P-loop; other site 1127744011541 ATP binding site [chemical binding]; other site 1127744011542 ABC transporter; Region: ABC_tran; pfam00005 1127744011543 Q-loop/lid; other site 1127744011544 ABC transporter signature motif; other site 1127744011545 Walker B; other site 1127744011546 D-loop; other site 1127744011547 H-loop/switch region; other site 1127744011548 LrgB-like family; Region: LrgB; cl00596 1127744011549 sugar efflux transporter; Region: 2A0120; TIGR00899 1127744011550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744011551 putative substrate translocation pore; other site 1127744011552 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1127744011553 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1127744011554 PUA domain; Region: PUA; cl00607 1127744011555 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1127744011556 putative RNA binding site [nucleotide binding]; other site 1127744011557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744011558 S-adenosylmethionine binding site [chemical binding]; other site 1127744011559 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127744011560 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1127744011561 active site 1127744011562 metal binding site [ion binding]; metal-binding site 1127744011563 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1127744011564 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1127744011565 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1127744011566 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1127744011567 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1127744011568 active site 1127744011569 catalytic residues [active] 1127744011570 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1127744011571 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1127744011572 active site turn [active] 1127744011573 phosphorylation site [posttranslational modification] 1127744011574 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1127744011575 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1127744011576 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1127744011577 PRD domain; Region: PRD; pfam00874 1127744011578 PRD domain; Region: PRD; pfam00874 1127744011579 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1127744011580 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1127744011581 Ligand binding site; other site 1127744011582 metal-binding site 1127744011583 Predicted integral membrane protein [Function unknown]; Region: COG5522 1127744011584 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744011585 MarR family; Region: MarR; pfam01047 1127744011586 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1127744011587 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1127744011588 active site 1127744011589 HIGH motif; other site 1127744011590 dimer interface [polypeptide binding]; other site 1127744011591 KMSKS motif; other site 1127744011592 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1127744011593 RNA binding surface [nucleotide binding]; other site 1127744011594 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1127744011595 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1127744011596 PA/protease domain interface [polypeptide binding]; other site 1127744011597 putative integrin binding motif; other site 1127744011598 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1127744011599 Peptidase family M28; Region: Peptidase_M28; pfam04389 1127744011600 metal binding site [ion binding]; metal-binding site 1127744011601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1127744011602 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1127744011603 salt bridge; other site 1127744011604 non-specific DNA binding site [nucleotide binding]; other site 1127744011605 sequence-specific DNA binding site [nucleotide binding]; other site 1127744011606 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1127744011607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744011608 putative substrate translocation pore; other site 1127744011609 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1127744011610 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1127744011611 synthetase active site [active] 1127744011612 NTP binding site [chemical binding]; other site 1127744011613 metal binding site [ion binding]; metal-binding site 1127744011614 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1127744011615 UbiA prenyltransferase family; Region: UbiA; pfam01040 1127744011616 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1127744011617 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1127744011618 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1127744011619 acyl-activating enzyme (AAE) consensus motif; other site 1127744011620 AMP binding site [chemical binding]; other site 1127744011621 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1127744011622 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1127744011623 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1127744011624 DltD N-terminal region; Region: DltD_N; pfam04915 1127744011625 DltD central region; Region: DltD_M; pfam04918 1127744011626 DltD C-terminal region; Region: DltD_C; pfam04914 1127744011627 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1127744011628 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1127744011629 putative NAD(P) binding site [chemical binding]; other site 1127744011630 active site 1127744011631 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1127744011632 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1127744011633 homodimer interface [polypeptide binding]; other site 1127744011634 substrate-cofactor binding pocket; other site 1127744011635 catalytic residue [active] 1127744011636 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1127744011637 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1127744011638 NAD binding site [chemical binding]; other site 1127744011639 sugar binding site [chemical binding]; other site 1127744011640 divalent metal binding site [ion binding]; other site 1127744011641 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1127744011642 dimer interface [polypeptide binding]; other site 1127744011643 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1127744011644 methionine cluster; other site 1127744011645 active site 1127744011646 phosphorylation site [posttranslational modification] 1127744011647 metal binding site [ion binding]; metal-binding site 1127744011648 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1127744011649 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1127744011650 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1127744011651 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1127744011652 HTH domain; Region: HTH_11; pfam08279 1127744011653 Mga helix-turn-helix domain; Region: Mga; pfam05043 1127744011654 PRD domain; Region: PRD; pfam00874 1127744011655 PRD domain; Region: PRD; pfam00874 1127744011656 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1127744011657 active site 1127744011658 P-loop; other site 1127744011659 phosphorylation site [posttranslational modification] 1127744011660 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1127744011661 active site 1127744011662 phosphorylation site [posttranslational modification] 1127744011663 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1127744011664 active site 1127744011665 DNA binding site [nucleotide binding] 1127744011666 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1127744011667 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1127744011668 tetramer interface [polypeptide binding]; other site 1127744011669 heme binding pocket [chemical binding]; other site 1127744011670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744011671 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744011672 putative substrate translocation pore; other site 1127744011673 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1127744011674 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1127744011675 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1127744011676 Walker A/P-loop; other site 1127744011677 ATP binding site [chemical binding]; other site 1127744011678 Q-loop/lid; other site 1127744011679 ABC transporter signature motif; other site 1127744011680 Walker B; other site 1127744011681 D-loop; other site 1127744011682 H-loop/switch region; other site 1127744011683 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1127744011684 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1127744011685 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 1127744011686 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1127744011687 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744011688 DNA binding residues [nucleotide binding] 1127744011689 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1127744011690 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1127744011691 Na binding site [ion binding]; other site 1127744011692 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1127744011693 putative substrate binding site [chemical binding]; other site 1127744011694 putative ATP binding site [chemical binding]; other site 1127744011695 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1127744011696 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1127744011697 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1127744011698 Walker A/P-loop; other site 1127744011699 ATP binding site [chemical binding]; other site 1127744011700 Q-loop/lid; other site 1127744011701 ABC transporter signature motif; other site 1127744011702 Walker B; other site 1127744011703 D-loop; other site 1127744011704 H-loop/switch region; other site 1127744011705 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1127744011706 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1127744011707 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1127744011708 ATP binding site [chemical binding]; other site 1127744011709 Q-loop/lid; other site 1127744011710 ABC transporter signature motif; other site 1127744011711 Walker B; other site 1127744011712 D-loop; other site 1127744011713 H-loop/switch region; other site 1127744011714 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1127744011715 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1127744011716 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1127744011717 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1127744011718 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 1127744011719 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1127744011720 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1127744011721 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1127744011722 putative active site [active] 1127744011723 putative metal binding site [ion binding]; other site 1127744011724 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1127744011725 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1127744011726 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1127744011727 Walker A/P-loop; other site 1127744011728 ATP binding site [chemical binding]; other site 1127744011729 Q-loop/lid; other site 1127744011730 ABC transporter signature motif; other site 1127744011731 Walker B; other site 1127744011732 D-loop; other site 1127744011733 H-loop/switch region; other site 1127744011734 TOBE domain; Region: TOBE; pfam03459 1127744011735 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1127744011736 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1127744011737 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1127744011738 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1127744011739 NAD(P) binding site [chemical binding]; other site 1127744011740 catalytic residues [active] 1127744011741 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1127744011742 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127744011743 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1127744011744 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1127744011745 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1127744011746 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1127744011747 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1127744011748 UDP-glucose 4-epimerase; Region: PLN02240 1127744011749 NAD binding site [chemical binding]; other site 1127744011750 homodimer interface [polypeptide binding]; other site 1127744011751 active site 1127744011752 substrate binding site [chemical binding]; other site 1127744011753 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1127744011754 Histidine kinase; Region: HisKA_3; pfam07730 1127744011755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744011756 ATP binding site [chemical binding]; other site 1127744011757 Mg2+ binding site [ion binding]; other site 1127744011758 G-X-G motif; other site 1127744011759 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1127744011760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744011761 active site 1127744011762 phosphorylation site [posttranslational modification] 1127744011763 intermolecular recognition site; other site 1127744011764 dimerization interface [polypeptide binding]; other site 1127744011765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1127744011766 DNA binding residues [nucleotide binding] 1127744011767 dimerization interface [polypeptide binding]; other site 1127744011768 peptidase T; Region: peptidase-T; TIGR01882 1127744011769 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1127744011770 metal binding site [ion binding]; metal-binding site 1127744011771 dimer interface [polypeptide binding]; other site 1127744011772 Tubby C 2; Region: Tub_2; cl02043 1127744011773 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1127744011774 substrate binding site [chemical binding]; other site 1127744011775 THF binding site; other site 1127744011776 zinc-binding site [ion binding]; other site 1127744011777 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1127744011778 substrate binding site [chemical binding]; other site 1127744011779 THF binding site; other site 1127744011780 zinc-binding site [ion binding]; other site 1127744011781 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1127744011782 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1127744011783 NAD binding site [chemical binding]; other site 1127744011784 homotetramer interface [polypeptide binding]; other site 1127744011785 homodimer interface [polypeptide binding]; other site 1127744011786 substrate binding site [chemical binding]; other site 1127744011787 active site 1127744011788 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1127744011789 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1127744011790 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1127744011791 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1127744011792 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1127744011793 nucleoside transporter; Region: nupC; TIGR00804 1127744011794 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1127744011795 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1127744011796 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1127744011797 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1127744011798 hydroperoxidase II; Provisional; Region: katE; PRK11249 1127744011799 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1127744011800 tetramer interface [polypeptide binding]; other site 1127744011801 heme binding pocket [chemical binding]; other site 1127744011802 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1127744011803 domain interactions; other site 1127744011804 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1127744011805 Citrate transporter; Region: CitMHS; pfam03600 1127744011806 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1127744011807 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1127744011808 active site 1127744011809 active site 1127744011810 catalytic residues [active] 1127744011811 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1127744011812 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1127744011813 PRD domain; Region: PRD; pfam00874 1127744011814 PRD domain; Region: PRD; pfam00874 1127744011815 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1127744011816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744011817 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1127744011818 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1127744011819 ATP binding site [chemical binding]; other site 1127744011820 Mg++ binding site [ion binding]; other site 1127744011821 motif III; other site 1127744011822 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1127744011823 nucleotide binding region [chemical binding]; other site 1127744011824 ATP-binding site [chemical binding]; other site 1127744011825 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1127744011826 RNA binding site [nucleotide binding]; other site 1127744011827 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1127744011828 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1127744011829 active site 1127744011830 catalytic triad [active] 1127744011831 YxiJ-like protein; Region: YxiJ; pfam14176 1127744011832 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 1127744011833 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1127744011834 YxiJ-like protein; Region: YxiJ; pfam14176 1127744011835 RHS Repeat; Region: RHS_repeat; pfam05593 1127744011836 RHS Repeat; Region: RHS_repeat; pfam05593 1127744011837 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1127744011838 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1127744011839 RHS Repeat; Region: RHS_repeat; pfam05593 1127744011840 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1127744011841 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1127744011842 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1127744011843 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1127744011844 EamA-like transporter family; Region: EamA; pfam00892 1127744011845 EamA-like transporter family; Region: EamA; pfam00892 1127744011846 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1127744011847 classical (c) SDRs; Region: SDR_c; cd05233 1127744011848 NAD(P) binding site [chemical binding]; other site 1127744011849 active site 1127744011850 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1127744011851 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1127744011852 Ligand Binding Site [chemical binding]; other site 1127744011853 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1127744011854 beta-galactosidase; Region: BGL; TIGR03356 1127744011855 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1127744011856 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1127744011857 active site turn [active] 1127744011858 phosphorylation site [posttranslational modification] 1127744011859 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1127744011860 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1127744011861 HPr interaction site; other site 1127744011862 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1127744011863 active site 1127744011864 phosphorylation site [posttranslational modification] 1127744011865 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763 1127744011866 LXG domain of WXG superfamily; Region: LXG; pfam04740 1127744011867 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1127744011868 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1127744011869 substrate binding site [chemical binding]; other site 1127744011870 active site 1127744011871 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1127744011872 hexamer interface [polypeptide binding]; other site 1127744011873 RNA binding site [nucleotide binding]; other site 1127744011874 Histidine-zinc binding site [chemical binding]; other site 1127744011875 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1127744011876 active sites [active] 1127744011877 tetramer interface [polypeptide binding]; other site 1127744011878 urocanate hydratase; Provisional; Region: PRK05414 1127744011879 imidazolonepropionase; Validated; Region: PRK09356 1127744011880 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1127744011881 active site 1127744011882 Agmatinase-like family; Region: Agmatinase-like; cd09990 1127744011883 agmatinase; Region: agmatinase; TIGR01230 1127744011884 active site 1127744011885 oligomer interface [polypeptide binding]; other site 1127744011886 Mn binding site [ion binding]; other site 1127744011887 S-methylmethionine transporter; Provisional; Region: PRK11387 1127744011888 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1127744011889 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1127744011890 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1127744011891 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1127744011892 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1127744011893 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1127744011894 Nucleoside recognition; Region: Gate; pfam07670 1127744011895 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1127744011896 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1127744011897 intersubunit interface [polypeptide binding]; other site 1127744011898 active site 1127744011899 catalytic residue [active] 1127744011900 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1127744011901 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1127744011902 DNA binding residues [nucleotide binding] 1127744011903 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1127744011904 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1127744011905 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1127744011906 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1127744011907 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1127744011908 MmgE/PrpD family; Region: MmgE_PrpD; pfam03972 1127744011909 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1127744011910 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1127744011911 metal binding site [ion binding]; metal-binding site 1127744011912 dimer interface [polypeptide binding]; other site 1127744011913 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1127744011914 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1127744011915 Walker A/P-loop; other site 1127744011916 ATP binding site [chemical binding]; other site 1127744011917 Q-loop/lid; other site 1127744011918 ABC transporter signature motif; other site 1127744011919 Walker B; other site 1127744011920 D-loop; other site 1127744011921 H-loop/switch region; other site 1127744011922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1127744011923 dimer interface [polypeptide binding]; other site 1127744011924 conserved gate region; other site 1127744011925 putative PBP binding loops; other site 1127744011926 ABC-ATPase subunit interface; other site 1127744011927 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1127744011928 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1127744011929 substrate binding pocket [chemical binding]; other site 1127744011930 membrane-bound complex binding site; other site 1127744011931 hinge residues; other site 1127744011932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744011933 Coenzyme A binding pocket [chemical binding]; other site 1127744011934 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1127744011935 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1127744011936 active site 1127744011937 non-prolyl cis peptide bond; other site 1127744011938 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1127744011939 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1127744011940 active site 1127744011941 sugar phosphate phosphatase; Provisional; Region: PRK10513 1127744011942 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744011943 active site 1127744011944 motif I; other site 1127744011945 motif II; other site 1127744011946 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1127744011947 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1127744011948 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1127744011949 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1127744011950 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1127744011951 putative ligand binding residues [chemical binding]; other site 1127744011952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1127744011953 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1127744011954 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1127744011955 Walker A/P-loop; other site 1127744011956 ATP binding site [chemical binding]; other site 1127744011957 Q-loop/lid; other site 1127744011958 ABC transporter signature motif; other site 1127744011959 Walker B; other site 1127744011960 D-loop; other site 1127744011961 H-loop/switch region; other site 1127744011962 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1127744011963 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1127744011964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744011965 ATP binding site [chemical binding]; other site 1127744011966 Mg2+ binding site [ion binding]; other site 1127744011967 G-X-G motif; other site 1127744011968 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127744011969 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744011970 active site 1127744011971 phosphorylation site [posttranslational modification] 1127744011972 intermolecular recognition site; other site 1127744011973 dimerization interface [polypeptide binding]; other site 1127744011974 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127744011975 DNA binding site [nucleotide binding] 1127744011976 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1127744011977 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1127744011978 intersubunit interface [polypeptide binding]; other site 1127744011979 active site 1127744011980 zinc binding site [ion binding]; other site 1127744011981 Na+ binding site [ion binding]; other site 1127744011982 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1127744011983 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1127744011984 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1127744011985 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1127744011986 DNA interaction; other site 1127744011987 Metal-binding active site; metal-binding site 1127744011988 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1127744011989 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1127744011990 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1127744011991 Glucuronate isomerase; Region: UxaC; cl00829 1127744011992 benzoate transport; Region: 2A0115; TIGR00895 1127744011993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744011994 putative substrate translocation pore; other site 1127744011995 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1127744011996 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1127744011997 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1127744011998 PYR/PP interface [polypeptide binding]; other site 1127744011999 dimer interface [polypeptide binding]; other site 1127744012000 TPP binding site [chemical binding]; other site 1127744012001 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1127744012002 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1127744012003 TPP-binding site; other site 1127744012004 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1127744012005 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1127744012006 substrate binding site [chemical binding]; other site 1127744012007 ATP binding site [chemical binding]; other site 1127744012008 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1127744012009 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1127744012010 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1127744012011 tetrameric interface [polypeptide binding]; other site 1127744012012 NAD binding site [chemical binding]; other site 1127744012013 catalytic residues [active] 1127744012014 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1127744012015 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1127744012016 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1127744012017 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1127744012018 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1127744012019 active site 1127744012020 catalytic tetrad [active] 1127744012021 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 1127744012022 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1127744012023 CGNR zinc finger; Region: zf-CGNR; pfam11706 1127744012024 HPP family; Region: HPP; pfam04982 1127744012025 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1127744012026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744012027 putative substrate translocation pore; other site 1127744012028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744012029 heat shock protein 90; Provisional; Region: PRK05218 1127744012030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744012031 ATP binding site [chemical binding]; other site 1127744012032 Mg2+ binding site [ion binding]; other site 1127744012033 G-X-G motif; other site 1127744012034 short chain dehydrogenase; Validated; Region: PRK08589 1127744012035 classical (c) SDRs; Region: SDR_c; cd05233 1127744012036 NAD(P) binding site [chemical binding]; other site 1127744012037 active site 1127744012038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744012039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744012040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744012041 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1127744012042 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1127744012043 NAD(P) binding site [chemical binding]; other site 1127744012044 catalytic residues [active] 1127744012045 RDD family; Region: RDD; pfam06271 1127744012046 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1127744012047 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1127744012048 active site 1127744012049 Trp docking motif [polypeptide binding]; other site 1127744012050 RDD family; Region: RDD; pfam06271 1127744012051 Predicted membrane protein [Function unknown]; Region: COG2311 1127744012052 Protein of unknown function (DUF418); Region: DUF418; cl12135 1127744012053 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1127744012054 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1127744012055 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1127744012056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1127744012057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1127744012058 short chain dehydrogenase; Provisional; Region: PRK07109 1127744012059 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1127744012060 putative NAD(P) binding site [chemical binding]; other site 1127744012061 active site 1127744012062 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744012063 MarR family; Region: MarR; pfam01047 1127744012064 LrgA family; Region: LrgA; cl00608 1127744012065 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1127744012066 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 1127744012067 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1127744012068 nucleophilic elbow; other site 1127744012069 catalytic triad; other site 1127744012070 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1127744012071 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1127744012072 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1127744012073 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1127744012074 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1127744012075 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1127744012076 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1127744012077 DNA-binding site [nucleotide binding]; DNA binding site 1127744012078 FCD domain; Region: FCD; pfam07729 1127744012079 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1127744012080 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1127744012081 N- and C-terminal domain interface [polypeptide binding]; other site 1127744012082 active site 1127744012083 catalytic site [active] 1127744012084 metal binding site [ion binding]; metal-binding site 1127744012085 carbohydrate binding site [chemical binding]; other site 1127744012086 ATP binding site [chemical binding]; other site 1127744012087 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1127744012088 gluconate transporter; Region: gntP; TIGR00791 1127744012089 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1127744012090 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1127744012091 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1127744012092 peroxiredoxin; Region: AhpC; TIGR03137 1127744012093 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1127744012094 dimer interface [polypeptide binding]; other site 1127744012095 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1127744012096 catalytic triad [active] 1127744012097 peroxidatic and resolving cysteines [active] 1127744012098 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1127744012099 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1127744012100 catalytic residue [active] 1127744012101 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1127744012102 catalytic residues [active] 1127744012103 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1127744012104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1127744012105 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1127744012106 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1127744012107 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1127744012108 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 1127744012109 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1127744012110 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1127744012111 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1127744012112 ATP binding site [chemical binding]; other site 1127744012113 putative Mg++ binding site [ion binding]; other site 1127744012114 silicon transporter; Region: sit; TIGR00811 1127744012115 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1127744012116 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1127744012117 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1127744012118 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1127744012119 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1127744012120 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1127744012121 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1127744012122 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1127744012123 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1127744012124 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1127744012125 NAD binding site [chemical binding]; other site 1127744012126 catalytic Zn binding site [ion binding]; other site 1127744012127 structural Zn binding site [ion binding]; other site 1127744012128 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1127744012129 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1127744012130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744012131 Coenzyme A binding pocket [chemical binding]; other site 1127744012132 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744012133 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1127744012134 Arginase family; Region: Arginase; cd09989 1127744012135 agmatinase; Region: agmatinase; TIGR01230 1127744012136 active site 1127744012137 Mn binding site [ion binding]; other site 1127744012138 oligomer interface [polypeptide binding]; other site 1127744012139 S-methylmethionine transporter; Provisional; Region: PRK11387 1127744012140 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1127744012141 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1127744012142 inhibitor-cofactor binding pocket; inhibition site 1127744012143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1127744012144 catalytic residue [active] 1127744012145 PAS domain; Region: PAS; smart00091 1127744012146 PAS domain; Region: PAS_9; pfam13426 1127744012147 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1127744012148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1127744012149 Walker A motif; other site 1127744012150 ATP binding site [chemical binding]; other site 1127744012151 Walker B motif; other site 1127744012152 arginine finger; other site 1127744012153 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1127744012154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744012155 dimerization interface [polypeptide binding]; other site 1127744012156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744012157 dimer interface [polypeptide binding]; other site 1127744012158 phosphorylation site [posttranslational modification] 1127744012159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744012160 ATP binding site [chemical binding]; other site 1127744012161 Mg2+ binding site [ion binding]; other site 1127744012162 G-X-G motif; other site 1127744012163 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127744012164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744012165 active site 1127744012166 phosphorylation site [posttranslational modification] 1127744012167 intermolecular recognition site; other site 1127744012168 dimerization interface [polypeptide binding]; other site 1127744012169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127744012170 DNA binding site [nucleotide binding] 1127744012171 Predicted membrane protein [Function unknown]; Region: COG3212 1127744012172 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1127744012173 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1127744012174 Predicted membrane protein [Function unknown]; Region: COG3212 1127744012175 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1127744012176 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1127744012177 Predicted membrane protein [Function unknown]; Region: COG3212 1127744012178 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1127744012179 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1127744012180 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1127744012181 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1127744012182 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1127744012183 protein binding site [polypeptide binding]; other site 1127744012184 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1127744012185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 1127744012186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1127744012187 YycH protein; Region: YycH; pfam07435 1127744012188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1127744012189 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1127744012190 dimerization interface [polypeptide binding]; other site 1127744012191 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1127744012192 putative active site [active] 1127744012193 heme pocket [chemical binding]; other site 1127744012194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1127744012195 dimer interface [polypeptide binding]; other site 1127744012196 phosphorylation site [posttranslational modification] 1127744012197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1127744012198 ATP binding site [chemical binding]; other site 1127744012199 Mg2+ binding site [ion binding]; other site 1127744012200 G-X-G motif; other site 1127744012201 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1127744012202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1127744012203 active site 1127744012204 phosphorylation site [posttranslational modification] 1127744012205 intermolecular recognition site; other site 1127744012206 dimerization interface [polypeptide binding]; other site 1127744012207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1127744012208 DNA binding site [nucleotide binding] 1127744012209 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1127744012210 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1127744012211 GDP-binding site [chemical binding]; other site 1127744012212 ACT binding site; other site 1127744012213 IMP binding site; other site 1127744012214 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127744012215 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1127744012216 active site 1127744012217 replicative DNA helicase; Provisional; Region: PRK05748 1127744012218 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1127744012219 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1127744012220 Walker A motif; other site 1127744012221 ATP binding site [chemical binding]; other site 1127744012222 Walker B motif; other site 1127744012223 DNA binding loops [nucleotide binding] 1127744012224 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1127744012225 YycC-like protein; Region: YycC; pfam14174 1127744012226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744012227 cyanate transporter; Region: CynX; TIGR00896 1127744012228 putative substrate translocation pore; other site 1127744012229 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1127744012230 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1127744012231 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1127744012232 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1127744012233 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1127744012234 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1127744012235 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1127744012236 diguanylate cyclase; Region: GGDEF; smart00267 1127744012237 DHH family; Region: DHH; pfam01368 1127744012238 DHHA1 domain; Region: DHHA1; pfam02272 1127744012239 Predicted membrane protein [Function unknown]; Region: COG4241 1127744012240 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1127744012241 Predicted transcriptional regulators [Transcription]; Region: COG1733 1127744012242 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1127744012243 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1127744012244 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1127744012245 DHHA2 domain; Region: DHHA2; pfam02833 1127744012246 ANTAR domain; Region: ANTAR; cl04297 1127744012247 D-galactonate transporter; Region: 2A0114; TIGR00893 1127744012248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744012249 putative substrate translocation pore; other site 1127744012250 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1127744012251 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1127744012252 putative dimer interface [polypeptide binding]; other site 1127744012253 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1127744012254 SnoaL-like domain; Region: SnoaL_3; pfam13474 1127744012255 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1127744012256 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1127744012257 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1127744012258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744012259 putative substrate translocation pore; other site 1127744012260 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1127744012261 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1127744012262 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1127744012263 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1127744012264 putative dimerization interface [polypeptide binding]; other site 1127744012265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744012266 Coenzyme A binding pocket [chemical binding]; other site 1127744012267 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1127744012268 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1127744012269 MarR family; Region: MarR; pfam01047 1127744012270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744012271 Coenzyme A binding pocket [chemical binding]; other site 1127744012272 Predicted membrane protein [Function unknown]; Region: COG2364 1127744012273 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1127744012274 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1127744012275 Coenzyme A binding pocket [chemical binding]; other site 1127744012276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1127744012277 RibD C-terminal domain; Region: RibD_C; cl17279 1127744012278 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1127744012279 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1127744012280 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1127744012281 DNA binding residues [nucleotide binding] 1127744012282 putative dimer interface [polypeptide binding]; other site 1127744012283 EamA-like transporter family; Region: EamA; pfam00892 1127744012284 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1127744012285 EamA-like transporter family; Region: EamA; pfam00892 1127744012286 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1127744012287 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1127744012288 catalytic residues [active] 1127744012289 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1127744012290 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1127744012291 CAAX protease self-immunity; Region: Abi; pfam02517 1127744012292 benzoate transport; Region: 2A0115; TIGR00895 1127744012293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744012294 putative substrate translocation pore; other site 1127744012295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1127744012296 maltose O-acetyltransferase; Provisional; Region: PRK10092 1127744012297 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1127744012298 active site 1127744012299 substrate binding site [chemical binding]; other site 1127744012300 trimer interface [polypeptide binding]; other site 1127744012301 CoA binding site [chemical binding]; other site 1127744012302 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1127744012303 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1127744012304 putative metal binding site [ion binding]; other site 1127744012305 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1127744012306 DNA binding site [nucleotide binding] 1127744012307 domain linker motif; other site 1127744012308 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1127744012309 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1127744012310 putative dimerization interface [polypeptide binding]; other site 1127744012311 putative ligand binding site [chemical binding]; other site 1127744012312 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1127744012313 active site 1127744012314 putative catalytic site [active] 1127744012315 DNA binding site [nucleotide binding] 1127744012316 putative phosphate binding site [ion binding]; other site 1127744012317 metal binding site A [ion binding]; metal-binding site 1127744012318 AP binding site [nucleotide binding]; other site 1127744012319 metal binding site B [ion binding]; metal-binding site 1127744012320 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1127744012321 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1127744012322 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1127744012323 dimer interface [polypeptide binding]; other site 1127744012324 ssDNA binding site [nucleotide binding]; other site 1127744012325 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1127744012326 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1127744012327 GTP-binding protein YchF; Reviewed; Region: PRK09601 1127744012328 YchF GTPase; Region: YchF; cd01900 1127744012329 G1 box; other site 1127744012330 GTP/Mg2+ binding site [chemical binding]; other site 1127744012331 Switch I region; other site 1127744012332 G2 box; other site 1127744012333 Switch II region; other site 1127744012334 G3 box; other site 1127744012335 G4 box; other site 1127744012336 G5 box; other site 1127744012337 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1127744012338 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1127744012339 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1127744012340 putative [4Fe-4S] binding site [ion binding]; other site 1127744012341 putative molybdopterin cofactor binding site [chemical binding]; other site 1127744012342 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1127744012343 molybdopterin cofactor binding site; other site 1127744012344 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1127744012345 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1127744012346 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1127744012347 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1127744012348 ParB-like nuclease domain; Region: ParB; smart00470 1127744012349 KorB domain; Region: KorB; pfam08535 1127744012350 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1127744012351 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1127744012352 P-loop; other site 1127744012353 Magnesium ion binding site [ion binding]; other site 1127744012354 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1127744012355 Magnesium ion binding site [ion binding]; other site 1127744012356 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1127744012357 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1127744012358 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1127744012359 ParB-like nuclease domain; Region: ParB; smart00470 1127744012360 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1127744012361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1127744012362 S-adenosylmethionine binding site [chemical binding]; other site 1127744012363 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1127744012364 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1127744012365 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1127744012366 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1127744012367 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1127744012368 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1127744012369 G1 box; other site 1127744012370 GTP/Mg2+ binding site [chemical binding]; other site 1127744012371 Switch I region; other site 1127744012372 G2 box; other site 1127744012373 Switch II region; other site 1127744012374 G3 box; other site 1127744012375 G4 box; other site 1127744012376 G5 box; other site 1127744012377 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1127744012378 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1127744012379 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1127744012380 G-X-X-G motif; other site 1127744012381 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1127744012382 RxxxH motif; other site 1127744012383 OxaA-like protein precursor; Provisional; Region: PRK02463 1127744012384 OxaA-like protein precursor; Validated; Region: PRK02944 1127744012385 ribonuclease P; Reviewed; Region: rnpA; PRK00499