-- dump date 20140618_210938 -- class Genbank::misc_feature -- table misc_feature_note -- id note 326423000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 326423000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 326423000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423000004 Walker A motif; other site 326423000005 ATP binding site [chemical binding]; other site 326423000006 Walker B motif; other site 326423000007 arginine finger; other site 326423000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 326423000009 DnaA box-binding interface [nucleotide binding]; other site 326423000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 326423000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 326423000012 putative DNA binding surface [nucleotide binding]; other site 326423000013 dimer interface [polypeptide binding]; other site 326423000014 beta-clamp/clamp loader binding surface; other site 326423000015 beta-clamp/translesion DNA polymerase binding surface; other site 326423000016 S4 domain; Region: S4_2; pfam13275 326423000017 recombination protein F; Reviewed; Region: recF; PRK00064 326423000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 326423000019 Walker A/P-loop; other site 326423000020 ATP binding site [chemical binding]; other site 326423000021 Q-loop/lid; other site 326423000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326423000023 ABC transporter signature motif; other site 326423000024 Walker B; other site 326423000025 D-loop; other site 326423000026 H-loop/switch region; other site 326423000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 326423000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423000029 ATP binding site [chemical binding]; other site 326423000030 Mg2+ binding site [ion binding]; other site 326423000031 G-X-G motif; other site 326423000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 326423000033 anchoring element; other site 326423000034 dimer interface [polypeptide binding]; other site 326423000035 ATP binding site [chemical binding]; other site 326423000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 326423000037 active site 326423000038 putative metal-binding site [ion binding]; other site 326423000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 326423000040 DNA gyrase subunit A; Validated; Region: PRK05560 326423000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 326423000042 CAP-like domain; other site 326423000043 active site 326423000044 primary dimer interface [polypeptide binding]; other site 326423000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326423000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326423000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326423000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326423000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326423000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326423000051 YaaC-like Protein; Region: YaaC; pfam14175 326423000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 326423000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326423000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 326423000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 326423000056 active site 326423000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 326423000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 326423000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 326423000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 326423000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 326423000062 active site 326423000063 multimer interface [polypeptide binding]; other site 326423000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 326423000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 326423000066 predicted active site [active] 326423000067 catalytic triad [active] 326423000068 seryl-tRNA synthetase; Provisional; Region: PRK05431 326423000069 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 326423000070 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 326423000071 dimer interface [polypeptide binding]; other site 326423000072 active site 326423000073 motif 1; other site 326423000074 motif 2; other site 326423000075 motif 3; other site 326423000076 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 326423000077 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 326423000078 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 326423000079 Substrate-binding site [chemical binding]; other site 326423000080 Substrate specificity [chemical binding]; other site 326423000081 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 326423000082 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 326423000083 Substrate-binding site [chemical binding]; other site 326423000084 Substrate specificity [chemical binding]; other site 326423000085 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 326423000086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423000087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423000088 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 326423000089 active site 326423000090 Isochorismatase family; Region: Isochorismatase; pfam00857 326423000091 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 326423000092 catalytic triad [active] 326423000093 conserved cis-peptide bond; other site 326423000094 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 326423000095 nucleoside/Zn binding site; other site 326423000096 dimer interface [polypeptide binding]; other site 326423000097 catalytic motif [active] 326423000098 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 326423000099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423000100 Walker A motif; other site 326423000101 ATP binding site [chemical binding]; other site 326423000102 Walker B motif; other site 326423000103 arginine finger; other site 326423000104 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 326423000105 hypothetical protein; Validated; Region: PRK00153 326423000106 recombination protein RecR; Reviewed; Region: recR; PRK00076 326423000107 RecR protein; Region: RecR; pfam02132 326423000108 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 326423000109 putative active site [active] 326423000110 putative metal-binding site [ion binding]; other site 326423000111 tetramer interface [polypeptide binding]; other site 326423000112 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 326423000113 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 326423000114 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 326423000115 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 326423000116 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 326423000117 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 326423000118 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 326423000119 homodimer interface [polypeptide binding]; other site 326423000120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423000121 catalytic residue [active] 326423000122 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 326423000123 thymidylate kinase; Validated; Region: tmk; PRK00698 326423000124 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 326423000125 TMP-binding site; other site 326423000126 ATP-binding site [chemical binding]; other site 326423000127 Protein of unknown function (DUF970); Region: DUF970; pfam06153 326423000128 Protein of unknown function (DUF327); Region: DUF327; pfam03885 326423000129 DNA polymerase III subunit delta'; Validated; Region: PRK08058 326423000130 DNA polymerase III subunit delta'; Validated; Region: PRK08485 326423000131 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 326423000132 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 326423000133 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 326423000134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423000135 S-adenosylmethionine binding site [chemical binding]; other site 326423000136 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 326423000137 GIY-YIG motif/motif A; other site 326423000138 putative active site [active] 326423000139 putative metal binding site [ion binding]; other site 326423000140 Predicted methyltransferases [General function prediction only]; Region: COG0313 326423000141 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 326423000142 putative SAM binding site [chemical binding]; other site 326423000143 putative homodimer interface [polypeptide binding]; other site 326423000144 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 326423000145 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 326423000146 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 326423000147 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 326423000148 active site 326423000149 HIGH motif; other site 326423000150 KMSKS motif; other site 326423000151 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 326423000152 tRNA binding surface [nucleotide binding]; other site 326423000153 anticodon binding site; other site 326423000154 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 326423000155 dimer interface [polypeptide binding]; other site 326423000156 putative tRNA-binding site [nucleotide binding]; other site 326423000157 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 326423000158 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 326423000159 active site 326423000160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 326423000161 Domain of unknown function (DUF348); Region: DUF348; pfam03990 326423000162 Domain of unknown function (DUF348); Region: DUF348; pfam03990 326423000163 Domain of unknown function (DUF348); Region: DUF348; pfam03990 326423000164 G5 domain; Region: G5; pfam07501 326423000165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 326423000166 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 326423000167 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 326423000168 putative active site [active] 326423000169 putative metal binding site [ion binding]; other site 326423000170 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 326423000171 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 326423000172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423000173 S-adenosylmethionine binding site [chemical binding]; other site 326423000174 YabG peptidase U57; Region: Peptidase_U57; pfam05582 326423000175 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 326423000176 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 326423000177 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 326423000178 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 326423000179 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 326423000180 pur operon repressor; Provisional; Region: PRK09213 326423000181 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 326423000182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326423000183 active site 326423000184 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 326423000185 homotrimer interaction site [polypeptide binding]; other site 326423000186 putative active site [active] 326423000187 regulatory protein SpoVG; Reviewed; Region: PRK13259 326423000188 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 326423000189 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 326423000190 Substrate binding site; other site 326423000191 Mg++ binding site; other site 326423000192 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 326423000193 active site 326423000194 substrate binding site [chemical binding]; other site 326423000195 CoA binding site [chemical binding]; other site 326423000196 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 326423000197 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 326423000198 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326423000199 active site 326423000200 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 326423000201 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 326423000202 5S rRNA interface [nucleotide binding]; other site 326423000203 CTC domain interface [polypeptide binding]; other site 326423000204 L16 interface [polypeptide binding]; other site 326423000205 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 326423000206 putative active site [active] 326423000207 catalytic residue [active] 326423000208 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 326423000209 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 326423000210 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 326423000211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326423000212 ATP binding site [chemical binding]; other site 326423000213 putative Mg++ binding site [ion binding]; other site 326423000214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326423000215 nucleotide binding region [chemical binding]; other site 326423000216 ATP-binding site [chemical binding]; other site 326423000217 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 326423000218 stage V sporulation protein T; Region: spore_V_T; TIGR02851 326423000219 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 326423000220 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 326423000221 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 326423000222 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 326423000223 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 326423000224 putative SAM binding site [chemical binding]; other site 326423000225 putative homodimer interface [polypeptide binding]; other site 326423000226 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 326423000227 homodimer interface [polypeptide binding]; other site 326423000228 metal binding site [ion binding]; metal-binding site 326423000229 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 326423000230 homodimer interface [polypeptide binding]; other site 326423000231 active site 326423000232 putative chemical substrate binding site [chemical binding]; other site 326423000233 metal binding site [ion binding]; metal-binding site 326423000234 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326423000235 RNA binding surface [nucleotide binding]; other site 326423000236 sporulation protein YabP; Region: spore_yabP; TIGR02892 326423000237 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 326423000238 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 326423000239 Septum formation initiator; Region: DivIC; pfam04977 326423000240 hypothetical protein; Provisional; Region: PRK08582 326423000241 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 326423000242 RNA binding site [nucleotide binding]; other site 326423000243 stage II sporulation protein E; Region: spore_II_E; TIGR02865 326423000244 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326423000245 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 326423000246 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 326423000247 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 326423000248 metal ion-dependent adhesion site (MIDAS); other site 326423000249 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 326423000250 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326423000251 active site 326423000252 ATP binding site [chemical binding]; other site 326423000253 substrate binding site [chemical binding]; other site 326423000254 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 326423000255 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 326423000256 Ligand Binding Site [chemical binding]; other site 326423000257 TilS substrate C-terminal domain; Region: TilS_C; smart00977 326423000258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326423000259 active site 326423000260 FtsH Extracellular; Region: FtsH_ext; pfam06480 326423000261 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 326423000262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423000263 Walker A motif; other site 326423000264 ATP binding site [chemical binding]; other site 326423000265 Walker B motif; other site 326423000266 arginine finger; other site 326423000267 Peptidase family M41; Region: Peptidase_M41; pfam01434 326423000268 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 326423000269 nucleotide binding site [chemical binding]; other site 326423000270 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 326423000271 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 326423000272 dimerization interface [polypeptide binding]; other site 326423000273 domain crossover interface; other site 326423000274 redox-dependent activation switch; other site 326423000275 SurA N-terminal domain; Region: SurA_N_3; cl07813 326423000276 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 326423000277 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 326423000278 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 326423000279 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 326423000280 dimer interface [polypeptide binding]; other site 326423000281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423000282 catalytic residue [active] 326423000283 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 326423000284 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 326423000285 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 326423000286 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 326423000287 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 326423000288 glutamine binding [chemical binding]; other site 326423000289 catalytic triad [active] 326423000290 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 326423000291 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 326423000292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423000293 catalytic residue [active] 326423000294 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 326423000295 dihydropteroate synthase; Region: DHPS; TIGR01496 326423000296 substrate binding pocket [chemical binding]; other site 326423000297 dimer interface [polypeptide binding]; other site 326423000298 inhibitor binding site; inhibition site 326423000299 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 326423000300 homooctamer interface [polypeptide binding]; other site 326423000301 active site 326423000302 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 326423000303 catalytic center binding site [active] 326423000304 ATP binding site [chemical binding]; other site 326423000305 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 326423000306 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 326423000307 FMN binding site [chemical binding]; other site 326423000308 active site 326423000309 catalytic residues [active] 326423000310 substrate binding site [chemical binding]; other site 326423000311 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 326423000312 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 326423000313 dimer interface [polypeptide binding]; other site 326423000314 putative anticodon binding site; other site 326423000315 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 326423000316 motif 1; other site 326423000317 active site 326423000318 motif 2; other site 326423000319 motif 3; other site 326423000320 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 326423000321 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 326423000322 UvrB/uvrC motif; Region: UVR; pfam02151 326423000323 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 326423000324 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 326423000325 ADP binding site [chemical binding]; other site 326423000326 phosphagen binding site; other site 326423000327 substrate specificity loop; other site 326423000328 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 326423000329 Clp amino terminal domain; Region: Clp_N; pfam02861 326423000330 Clp amino terminal domain; Region: Clp_N; pfam02861 326423000331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423000332 Walker A motif; other site 326423000333 ATP binding site [chemical binding]; other site 326423000334 Walker B motif; other site 326423000335 arginine finger; other site 326423000336 UvrB/uvrC motif; Region: UVR; pfam02151 326423000337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423000338 Walker A motif; other site 326423000339 ATP binding site [chemical binding]; other site 326423000340 Walker B motif; other site 326423000341 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 326423000342 DNA repair protein RadA; Provisional; Region: PRK11823 326423000343 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 326423000344 Walker A motif/ATP binding site; other site 326423000345 ATP binding site [chemical binding]; other site 326423000346 Walker B motif; other site 326423000347 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 326423000348 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 326423000349 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 326423000350 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 326423000351 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 326423000352 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 326423000353 putative active site [active] 326423000354 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 326423000355 substrate binding site; other site 326423000356 dimer interface; other site 326423000357 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 326423000358 homotrimer interaction site [polypeptide binding]; other site 326423000359 zinc binding site [ion binding]; other site 326423000360 CDP-binding sites; other site 326423000361 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 326423000362 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 326423000363 HIGH motif; other site 326423000364 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 326423000365 active site 326423000366 KMSKS motif; other site 326423000367 serine O-acetyltransferase; Region: cysE; TIGR01172 326423000368 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 326423000369 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 326423000370 trimer interface [polypeptide binding]; other site 326423000371 active site 326423000372 substrate binding site [chemical binding]; other site 326423000373 CoA binding site [chemical binding]; other site 326423000374 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 326423000375 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 326423000376 active site 326423000377 HIGH motif; other site 326423000378 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 326423000379 KMSKS motif; other site 326423000380 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 326423000381 tRNA binding surface [nucleotide binding]; other site 326423000382 anticodon binding site; other site 326423000383 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 326423000384 active site 326423000385 metal binding site [ion binding]; metal-binding site 326423000386 dimerization interface [polypeptide binding]; other site 326423000387 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 326423000388 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 326423000389 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 326423000390 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 326423000391 RNA polymerase factor sigma-70; Validated; Region: PRK08295 326423000392 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326423000393 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 326423000394 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 326423000395 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 326423000396 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 326423000397 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 326423000398 putative homodimer interface [polypeptide binding]; other site 326423000399 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 326423000400 heterodimer interface [polypeptide binding]; other site 326423000401 homodimer interface [polypeptide binding]; other site 326423000402 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 326423000403 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 326423000404 23S rRNA interface [nucleotide binding]; other site 326423000405 L7/L12 interface [polypeptide binding]; other site 326423000406 putative thiostrepton binding site; other site 326423000407 L25 interface [polypeptide binding]; other site 326423000408 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 326423000409 mRNA/rRNA interface [nucleotide binding]; other site 326423000410 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 326423000411 23S rRNA interface [nucleotide binding]; other site 326423000412 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 326423000413 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 326423000414 core dimer interface [polypeptide binding]; other site 326423000415 peripheral dimer interface [polypeptide binding]; other site 326423000416 L10 interface [polypeptide binding]; other site 326423000417 L11 interface [polypeptide binding]; other site 326423000418 putative EF-Tu interaction site [polypeptide binding]; other site 326423000419 putative EF-G interaction site [polypeptide binding]; other site 326423000420 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 326423000421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423000422 S-adenosylmethionine binding site [chemical binding]; other site 326423000423 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 326423000424 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 326423000425 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 326423000426 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 326423000427 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 326423000428 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 326423000429 RPB1 interaction site [polypeptide binding]; other site 326423000430 RPB10 interaction site [polypeptide binding]; other site 326423000431 RPB11 interaction site [polypeptide binding]; other site 326423000432 RPB3 interaction site [polypeptide binding]; other site 326423000433 RPB12 interaction site [polypeptide binding]; other site 326423000434 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 326423000435 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 326423000436 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 326423000437 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 326423000438 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 326423000439 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 326423000440 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 326423000441 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 326423000442 G-loop; other site 326423000443 DNA binding site [nucleotide binding] 326423000444 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 326423000445 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 326423000446 S17 interaction site [polypeptide binding]; other site 326423000447 S8 interaction site; other site 326423000448 16S rRNA interaction site [nucleotide binding]; other site 326423000449 streptomycin interaction site [chemical binding]; other site 326423000450 23S rRNA interaction site [nucleotide binding]; other site 326423000451 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 326423000452 30S ribosomal protein S7; Validated; Region: PRK05302 326423000453 elongation factor G; Reviewed; Region: PRK00007 326423000454 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 326423000455 G1 box; other site 326423000456 putative GEF interaction site [polypeptide binding]; other site 326423000457 GTP/Mg2+ binding site [chemical binding]; other site 326423000458 Switch I region; other site 326423000459 G2 box; other site 326423000460 G3 box; other site 326423000461 Switch II region; other site 326423000462 G4 box; other site 326423000463 G5 box; other site 326423000464 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 326423000465 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 326423000466 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 326423000467 elongation factor Tu; Reviewed; Region: PRK00049 326423000468 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 326423000469 G1 box; other site 326423000470 GEF interaction site [polypeptide binding]; other site 326423000471 GTP/Mg2+ binding site [chemical binding]; other site 326423000472 Switch I region; other site 326423000473 G2 box; other site 326423000474 G3 box; other site 326423000475 Switch II region; other site 326423000476 G4 box; other site 326423000477 G5 box; other site 326423000478 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 326423000479 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 326423000480 Antibiotic Binding Site [chemical binding]; other site 326423000481 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326423000482 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 326423000483 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 326423000484 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 326423000485 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 326423000486 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 326423000487 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 326423000488 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 326423000489 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 326423000490 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 326423000491 putative translocon binding site; other site 326423000492 protein-rRNA interface [nucleotide binding]; other site 326423000493 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 326423000494 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 326423000495 G-X-X-G motif; other site 326423000496 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 326423000497 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 326423000498 23S rRNA interface [nucleotide binding]; other site 326423000499 5S rRNA interface [nucleotide binding]; other site 326423000500 putative antibiotic binding site [chemical binding]; other site 326423000501 L25 interface [polypeptide binding]; other site 326423000502 L27 interface [polypeptide binding]; other site 326423000503 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 326423000504 23S rRNA interface [nucleotide binding]; other site 326423000505 putative translocon interaction site; other site 326423000506 signal recognition particle (SRP54) interaction site; other site 326423000507 L23 interface [polypeptide binding]; other site 326423000508 trigger factor interaction site; other site 326423000509 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 326423000510 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 326423000511 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 326423000512 RNA binding site [nucleotide binding]; other site 326423000513 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 326423000514 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 326423000515 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 326423000516 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 326423000517 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 326423000518 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 326423000519 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 326423000520 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 326423000521 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 326423000522 5S rRNA interface [nucleotide binding]; other site 326423000523 L27 interface [polypeptide binding]; other site 326423000524 23S rRNA interface [nucleotide binding]; other site 326423000525 L5 interface [polypeptide binding]; other site 326423000526 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 326423000527 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 326423000528 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 326423000529 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 326423000530 23S rRNA binding site [nucleotide binding]; other site 326423000531 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 326423000532 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 326423000533 SecY translocase; Region: SecY; pfam00344 326423000534 adenylate kinase; Reviewed; Region: adk; PRK00279 326423000535 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 326423000536 AMP-binding site [chemical binding]; other site 326423000537 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 326423000538 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 326423000539 active site 326423000540 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 326423000541 rRNA binding site [nucleotide binding]; other site 326423000542 predicted 30S ribosome binding site; other site 326423000543 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 326423000544 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 326423000545 30S ribosomal protein S13; Region: bact_S13; TIGR03631 326423000546 30S ribosomal protein S11; Validated; Region: PRK05309 326423000547 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 326423000548 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 326423000549 alphaNTD homodimer interface [polypeptide binding]; other site 326423000550 alphaNTD - beta interaction site [polypeptide binding]; other site 326423000551 alphaNTD - beta' interaction site [polypeptide binding]; other site 326423000552 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 326423000553 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 326423000554 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 326423000555 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326423000556 Walker A/P-loop; other site 326423000557 ATP binding site [chemical binding]; other site 326423000558 Q-loop/lid; other site 326423000559 ABC transporter signature motif; other site 326423000560 Walker B; other site 326423000561 D-loop; other site 326423000562 H-loop/switch region; other site 326423000563 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 326423000564 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326423000565 Walker A/P-loop; other site 326423000566 ATP binding site [chemical binding]; other site 326423000567 Q-loop/lid; other site 326423000568 ABC transporter signature motif; other site 326423000569 Walker B; other site 326423000570 D-loop; other site 326423000571 H-loop/switch region; other site 326423000572 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 326423000573 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 326423000574 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 326423000575 dimerization interface 3.5A [polypeptide binding]; other site 326423000576 active site 326423000577 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 326423000578 23S rRNA interface [nucleotide binding]; other site 326423000579 L3 interface [polypeptide binding]; other site 326423000580 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 326423000581 Methyltransferase domain; Region: Methyltransf_31; pfam13847 326423000582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423000583 S-adenosylmethionine binding site [chemical binding]; other site 326423000584 DinB family; Region: DinB; cl17821 326423000585 DinB superfamily; Region: DinB_2; pfam12867 326423000586 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 326423000587 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 326423000588 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 326423000589 active site 326423000590 metal binding site [ion binding]; metal-binding site 326423000591 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 326423000592 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 326423000593 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 326423000594 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 326423000595 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 326423000596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423000597 putative substrate translocation pore; other site 326423000598 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 326423000599 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326423000600 inhibitor-cofactor binding pocket; inhibition site 326423000601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423000602 catalytic residue [active] 326423000603 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 326423000604 active site 326423000605 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 326423000606 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 326423000607 NAD(P) binding site [chemical binding]; other site 326423000608 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 326423000609 Sulfate transporter family; Region: Sulfate_transp; pfam00916 326423000610 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 326423000611 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 326423000612 Sodium Bile acid symporter family; Region: SBF; cl17470 326423000613 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 326423000614 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 326423000615 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 326423000616 ABC-ATPase subunit interface; other site 326423000617 dimer interface [polypeptide binding]; other site 326423000618 putative PBP binding regions; other site 326423000619 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 326423000620 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 326423000621 ABC-ATPase subunit interface; other site 326423000622 dimer interface [polypeptide binding]; other site 326423000623 putative PBP binding regions; other site 326423000624 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 326423000625 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 326423000626 intersubunit interface [polypeptide binding]; other site 326423000627 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326423000628 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 326423000629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326423000630 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 326423000631 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 326423000632 intersubunit interface [polypeptide binding]; other site 326423000633 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 326423000634 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 326423000635 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 326423000636 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 326423000637 putative periplasmic esterase; Provisional; Region: PRK03642 326423000638 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 326423000639 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 326423000640 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 326423000641 active site turn [active] 326423000642 phosphorylation site [posttranslational modification] 326423000643 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 326423000644 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 326423000645 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 326423000646 putative active site [active] 326423000647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326423000648 Uncharacterized conserved protein [Function unknown]; Region: COG1683 326423000649 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 326423000650 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326423000651 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423000652 DNA binding residues [nucleotide binding] 326423000653 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 326423000654 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 326423000655 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 326423000656 Uncharacterized conserved protein [Function unknown]; Region: COG1624 326423000657 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 326423000658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 326423000659 YbbR-like protein; Region: YbbR; pfam07949 326423000660 YbbR-like protein; Region: YbbR; pfam07949 326423000661 YbbR-like protein; Region: YbbR; pfam07949 326423000662 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 326423000663 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 326423000664 active site 326423000665 substrate binding site [chemical binding]; other site 326423000666 metal binding site [ion binding]; metal-binding site 326423000667 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 326423000668 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 326423000669 glutaminase active site [active] 326423000670 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 326423000671 dimer interface [polypeptide binding]; other site 326423000672 active site 326423000673 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 326423000674 dimer interface [polypeptide binding]; other site 326423000675 active site 326423000676 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 326423000677 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326423000678 Walker A/P-loop; other site 326423000679 ATP binding site [chemical binding]; other site 326423000680 Q-loop/lid; other site 326423000681 ABC transporter signature motif; other site 326423000682 Walker B; other site 326423000683 D-loop; other site 326423000684 H-loop/switch region; other site 326423000685 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 326423000686 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423000687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423000688 active site 326423000689 phosphorylation site [posttranslational modification] 326423000690 intermolecular recognition site; other site 326423000691 dimerization interface [polypeptide binding]; other site 326423000692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423000693 DNA binding site [nucleotide binding] 326423000694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423000695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423000696 ATP binding site [chemical binding]; other site 326423000697 Mg2+ binding site [ion binding]; other site 326423000698 G-X-G motif; other site 326423000699 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326423000700 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326423000701 Walker A/P-loop; other site 326423000702 ATP binding site [chemical binding]; other site 326423000703 Q-loop/lid; other site 326423000704 ABC transporter signature motif; other site 326423000705 Walker B; other site 326423000706 D-loop; other site 326423000707 H-loop/switch region; other site 326423000708 FtsX-like permease family; Region: FtsX; pfam02687 326423000709 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326423000710 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326423000711 active site 326423000712 catalytic tetrad [active] 326423000713 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 326423000714 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423000715 MarR family; Region: MarR; pfam01047 326423000716 putative transport protein YifK; Provisional; Region: PRK10746 326423000717 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 326423000718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326423000719 Histidine kinase; Region: HisKA_3; pfam07730 326423000720 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326423000721 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326423000722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423000723 active site 326423000724 phosphorylation site [posttranslational modification] 326423000725 intermolecular recognition site; other site 326423000726 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 326423000727 dimerization interface [polypeptide binding]; other site 326423000728 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326423000729 DNA binding residues [nucleotide binding] 326423000730 dimerization interface [polypeptide binding]; other site 326423000731 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326423000732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326423000733 Walker A/P-loop; other site 326423000734 ATP binding site [chemical binding]; other site 326423000735 Q-loop/lid; other site 326423000736 ABC transporter signature motif; other site 326423000737 Walker B; other site 326423000738 D-loop; other site 326423000739 H-loop/switch region; other site 326423000740 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 326423000741 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 326423000742 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 326423000743 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 326423000744 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 326423000745 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 326423000746 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 326423000747 active site 326423000748 catalytic site [active] 326423000749 metal binding site [ion binding]; metal-binding site 326423000750 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 326423000751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423000752 putative substrate translocation pore; other site 326423000753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423000754 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 326423000755 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 326423000756 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 326423000757 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326423000758 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 326423000759 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326423000760 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 326423000761 active site 326423000762 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326423000763 non-specific DNA binding site [nucleotide binding]; other site 326423000764 salt bridge; other site 326423000765 sequence-specific DNA binding site [nucleotide binding]; other site 326423000766 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 326423000767 Glycerol_dehydrogenase-like; Region: GlyDH-like; cd08550 326423000768 active site 326423000769 NAD binding site [chemical binding]; other site 326423000770 metal binding site [ion binding]; metal-binding site 326423000771 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 326423000772 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326423000773 ATP-grasp domain; Region: ATP-grasp; pfam02222 326423000774 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 326423000775 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 326423000776 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 326423000777 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 326423000778 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 326423000779 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 326423000780 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 326423000781 active site residue [active] 326423000782 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 326423000783 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 326423000784 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 326423000785 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 326423000786 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 326423000787 homodimer interface [polypeptide binding]; other site 326423000788 substrate-cofactor binding pocket; other site 326423000789 catalytic residue [active] 326423000790 S-methylmethionine transporter; Provisional; Region: PRK11387 326423000791 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 326423000792 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 326423000793 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 326423000794 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 326423000795 glutaminase; Reviewed; Region: PRK12357 326423000796 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 326423000797 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423000798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423000799 ATP binding site [chemical binding]; other site 326423000800 Mg2+ binding site [ion binding]; other site 326423000801 G-X-G motif; other site 326423000802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423000803 Response regulator receiver domain; Region: Response_reg; pfam00072 326423000804 active site 326423000805 phosphorylation site [posttranslational modification] 326423000806 intermolecular recognition site; other site 326423000807 dimerization interface [polypeptide binding]; other site 326423000808 YcbB domain; Region: YcbB; pfam08664 326423000809 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326423000810 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 326423000811 dodecamer interface 1 [polypeptide binding]; other site 326423000812 dodecamer interface 2 [polypeptide binding]; other site 326423000813 trimer interface [polypeptide binding]; other site 326423000814 TRAP binding interface [polypeptide binding]; other site 326423000815 Zn binding site [ion binding]; other site 326423000816 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 326423000817 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 326423000818 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 326423000819 dimer interface [polypeptide binding]; other site 326423000820 FMN binding site [chemical binding]; other site 326423000821 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 326423000822 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326423000823 Zn binding site [ion binding]; other site 326423000824 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 326423000825 Zn binding site [ion binding]; other site 326423000826 Predicted membrane protein [Function unknown]; Region: COG2259 326423000827 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 326423000828 catalytic residues [active] 326423000829 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 326423000830 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 326423000831 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 326423000832 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 326423000833 putative active site [active] 326423000834 putative metal binding site [ion binding]; other site 326423000835 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 326423000836 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 326423000837 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 326423000838 putative substrate binding pocket [chemical binding]; other site 326423000839 AC domain interface; other site 326423000840 catalytic triad [active] 326423000841 AB domain interface; other site 326423000842 interchain disulfide; other site 326423000843 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 326423000844 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326423000845 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326423000846 catalytic residue [active] 326423000847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423000848 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326423000849 putative substrate translocation pore; other site 326423000850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423000851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423000852 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 326423000853 active site 326423000854 homotetramer interface [polypeptide binding]; other site 326423000855 homodimer interface [polypeptide binding]; other site 326423000856 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 326423000857 Lipase (class 2); Region: Lipase_2; pfam01674 326423000858 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 326423000859 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 326423000860 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326423000861 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326423000862 active site 326423000863 catalytic tetrad [active] 326423000864 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 326423000865 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 326423000866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326423000867 binding surface 326423000868 TPR motif; other site 326423000869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 326423000870 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423000871 TPR motif; other site 326423000872 binding surface 326423000873 glucose-1-dehydrogenase; Provisional; Region: PRK08936 326423000874 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 326423000875 NAD binding site [chemical binding]; other site 326423000876 homodimer interface [polypeptide binding]; other site 326423000877 active site 326423000878 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 326423000879 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 326423000880 Ca binding site [ion binding]; other site 326423000881 active site 326423000882 catalytic site [active] 326423000883 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 326423000884 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 326423000885 metal binding site [ion binding]; metal-binding site 326423000886 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 326423000887 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 326423000888 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 326423000889 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 326423000890 ABC-ATPase subunit interface; other site 326423000891 dimer interface [polypeptide binding]; other site 326423000892 putative PBP binding regions; other site 326423000893 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 326423000894 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326423000895 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 326423000896 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 326423000897 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 326423000898 putative metal binding site [ion binding]; other site 326423000899 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 326423000900 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 326423000901 putative metal binding site [ion binding]; other site 326423000902 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 326423000903 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 326423000904 putative metal binding site [ion binding]; other site 326423000905 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 326423000906 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 326423000907 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 326423000908 benzoate transport; Region: 2A0115; TIGR00895 326423000909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423000910 putative substrate translocation pore; other site 326423000911 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 326423000912 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 326423000913 Walker A/P-loop; other site 326423000914 ATP binding site [chemical binding]; other site 326423000915 Q-loop/lid; other site 326423000916 ABC transporter signature motif; other site 326423000917 Walker B; other site 326423000918 D-loop; other site 326423000919 H-loop/switch region; other site 326423000920 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 326423000921 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 326423000922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423000923 dimer interface [polypeptide binding]; other site 326423000924 conserved gate region; other site 326423000925 putative PBP binding loops; other site 326423000926 ABC-ATPase subunit interface; other site 326423000927 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 326423000928 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 326423000929 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 326423000930 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 326423000931 amidohydrolase; Region: amidohydrolases; TIGR01891 326423000932 metal binding site [ion binding]; metal-binding site 326423000933 putative dimer interface [polypeptide binding]; other site 326423000934 Predicted membrane protein [Function unknown]; Region: COG1288 326423000935 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 326423000936 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 326423000937 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 326423000938 active site 326423000939 Ca binding site [ion binding]; other site 326423000940 catalytic site [active] 326423000941 Aamy_C domain; Region: Aamy_C; smart00632 326423000942 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 326423000943 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 326423000944 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326423000945 NAD binding site [chemical binding]; other site 326423000946 dimer interface [polypeptide binding]; other site 326423000947 substrate binding site [chemical binding]; other site 326423000948 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326423000949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423000950 putative substrate translocation pore; other site 326423000951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423000952 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423000953 MarR family; Region: MarR; pfam01047 326423000954 LysE type translocator; Region: LysE; pfam01810 326423000955 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 326423000956 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 326423000957 Spore germination protein; Region: Spore_permease; cl17796 326423000958 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 326423000959 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 326423000960 NAD+ synthetase; Region: nadE; TIGR00552 326423000961 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 326423000962 homodimer interface [polypeptide binding]; other site 326423000963 NAD binding pocket [chemical binding]; other site 326423000964 ATP binding pocket [chemical binding]; other site 326423000965 Mg binding site [ion binding]; other site 326423000966 active-site loop [active] 326423000967 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 326423000968 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 326423000969 AAA domain; Region: AAA_18; pfam13238 326423000970 active site 326423000971 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 326423000972 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 326423000973 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 326423000974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423000975 D-galactonate transporter; Region: 2A0114; TIGR00893 326423000976 putative substrate translocation pore; other site 326423000977 shikimate kinase; Reviewed; Region: aroK; PRK00131 326423000978 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 326423000979 ADP binding site [chemical binding]; other site 326423000980 magnesium binding site [ion binding]; other site 326423000981 putative shikimate binding site; other site 326423000982 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 326423000983 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 326423000984 Proline dehydrogenase; Region: Pro_dh; pfam01619 326423000985 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 326423000986 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 326423000987 Glutamate binding site [chemical binding]; other site 326423000988 homodimer interface [polypeptide binding]; other site 326423000989 NAD binding site [chemical binding]; other site 326423000990 catalytic residues [active] 326423000991 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 326423000992 Na binding site [ion binding]; other site 326423000993 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 326423000994 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 326423000995 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 326423000996 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326423000997 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326423000998 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 326423000999 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 326423001000 active site 326423001001 SAM binding site [chemical binding]; other site 326423001002 homodimer interface [polypeptide binding]; other site 326423001003 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 326423001004 [2Fe-2S] cluster binding site [ion binding]; other site 326423001005 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 326423001006 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326423001007 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 326423001008 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 326423001009 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 326423001010 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 326423001011 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 326423001012 [4Fe-4S] binding site [ion binding]; other site 326423001013 molybdopterin cofactor binding site; other site 326423001014 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 326423001015 molybdopterin cofactor binding site; other site 326423001016 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 326423001017 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326423001018 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326423001019 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 326423001020 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 326423001021 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 326423001022 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 326423001023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423001024 putative substrate translocation pore; other site 326423001025 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 326423001026 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 326423001027 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 326423001028 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 326423001029 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 326423001030 NAD binding site [chemical binding]; other site 326423001031 catalytic Zn binding site [ion binding]; other site 326423001032 structural Zn binding site [ion binding]; other site 326423001033 RDD family; Region: RDD; pfam06271 326423001034 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 326423001035 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 326423001036 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 326423001037 Competence protein J (ComJ); Region: ComJ; pfam11033 326423001038 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 326423001039 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 326423001040 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 326423001041 tetramer interface [polypeptide binding]; other site 326423001042 active site 326423001043 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 326423001044 active site 326423001045 dimer interface [polypeptide binding]; other site 326423001046 magnesium binding site [ion binding]; other site 326423001047 Predicted transcriptional regulators [Transcription]; Region: COG1733 326423001048 Condensation domain; Region: Condensation; pfam00668 326423001049 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423001050 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423001051 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423001052 acyl-activating enzyme (AAE) consensus motif; other site 326423001053 AMP binding site [chemical binding]; other site 326423001054 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423001055 Condensation domain; Region: Condensation; pfam00668 326423001056 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423001057 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423001058 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 326423001059 acyl-activating enzyme (AAE) consensus motif; other site 326423001060 AMP binding site [chemical binding]; other site 326423001061 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423001062 Condensation domain; Region: Condensation; pfam00668 326423001063 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423001064 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423001065 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423001066 acyl-activating enzyme (AAE) consensus motif; other site 326423001067 AMP binding site [chemical binding]; other site 326423001068 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423001069 Condensation domain; Region: Condensation; pfam00668 326423001070 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 326423001071 Condensation domain; Region: Condensation; pfam00668 326423001072 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423001073 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 326423001074 acyl-activating enzyme (AAE) consensus motif; other site 326423001075 AMP binding site [chemical binding]; other site 326423001076 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423001077 Condensation domain; Region: Condensation; pfam00668 326423001078 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423001079 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423001080 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423001081 acyl-activating enzyme (AAE) consensus motif; other site 326423001082 AMP binding site [chemical binding]; other site 326423001083 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423001084 Condensation domain; Region: Condensation; pfam00668 326423001085 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423001086 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423001087 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423001088 acyl-activating enzyme (AAE) consensus motif; other site 326423001089 AMP binding site [chemical binding]; other site 326423001090 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423001091 Condensation domain; Region: Condensation; pfam00668 326423001092 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423001093 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 326423001094 Condensation domain; Region: Condensation; pfam00668 326423001095 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423001096 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 326423001097 acyl-activating enzyme (AAE) consensus motif; other site 326423001098 AMP binding site [chemical binding]; other site 326423001099 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423001100 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 326423001101 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326423001102 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 326423001103 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326423001104 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 326423001105 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326423001106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423001107 homodimer interface [polypeptide binding]; other site 326423001108 catalytic residue [active] 326423001109 YcxB-like protein; Region: YcxB; pfam14317 326423001110 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 326423001111 EamA-like transporter family; Region: EamA; pfam00892 326423001112 EamA-like transporter family; Region: EamA; pfam00892 326423001113 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 326423001114 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423001115 DNA-binding site [nucleotide binding]; DNA binding site 326423001116 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326423001117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423001118 homodimer interface [polypeptide binding]; other site 326423001119 catalytic residue [active] 326423001120 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 326423001121 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 326423001122 Predicted membrane protein [Function unknown]; Region: COG2364 326423001123 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423001124 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423001125 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326423001126 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326423001127 Walker A/P-loop; other site 326423001128 ATP binding site [chemical binding]; other site 326423001129 Q-loop/lid; other site 326423001130 ABC transporter signature motif; other site 326423001131 Walker B; other site 326423001132 D-loop; other site 326423001133 H-loop/switch region; other site 326423001134 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 326423001135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423001136 dimer interface [polypeptide binding]; other site 326423001137 conserved gate region; other site 326423001138 putative PBP binding loops; other site 326423001139 ABC-ATPase subunit interface; other site 326423001140 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 326423001141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326423001142 substrate binding pocket [chemical binding]; other site 326423001143 membrane-bound complex binding site; other site 326423001144 hinge residues; other site 326423001145 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423001146 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423001147 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326423001148 dimerization interface [polypeptide binding]; other site 326423001149 aromatic acid decarboxylase; Validated; Region: PRK05920 326423001150 Flavoprotein; Region: Flavoprotein; pfam02441 326423001151 UbiD family decarboxylase; Region: TIGR00148 326423001152 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 326423001153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423001154 putative substrate translocation pore; other site 326423001155 POT family; Region: PTR2; pfam00854 326423001156 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 326423001157 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 326423001158 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 326423001159 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 326423001160 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 326423001161 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 326423001162 Spore germination protein; Region: Spore_permease; pfam03845 326423001163 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 326423001164 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 326423001165 active site 326423001166 non-prolyl cis peptide bond; other site 326423001167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423001168 Coenzyme A binding pocket [chemical binding]; other site 326423001169 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326423001170 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326423001171 substrate binding pocket [chemical binding]; other site 326423001172 membrane-bound complex binding site; other site 326423001173 hinge residues; other site 326423001174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423001175 dimer interface [polypeptide binding]; other site 326423001176 conserved gate region; other site 326423001177 putative PBP binding loops; other site 326423001178 ABC-ATPase subunit interface; other site 326423001179 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326423001180 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326423001181 Walker A/P-loop; other site 326423001182 ATP binding site [chemical binding]; other site 326423001183 Q-loop/lid; other site 326423001184 ABC transporter signature motif; other site 326423001185 Walker B; other site 326423001186 D-loop; other site 326423001187 H-loop/switch region; other site 326423001188 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 326423001189 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 326423001190 metal binding site [ion binding]; metal-binding site 326423001191 dimer interface [polypeptide binding]; other site 326423001192 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 326423001193 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326423001194 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326423001195 Walker A/P-loop; other site 326423001196 ATP binding site [chemical binding]; other site 326423001197 Q-loop/lid; other site 326423001198 ABC transporter signature motif; other site 326423001199 Walker B; other site 326423001200 D-loop; other site 326423001201 H-loop/switch region; other site 326423001202 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326423001203 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 326423001204 FtsX-like permease family; Region: FtsX; pfam02687 326423001205 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423001206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423001207 active site 326423001208 phosphorylation site [posttranslational modification] 326423001209 intermolecular recognition site; other site 326423001210 dimerization interface [polypeptide binding]; other site 326423001211 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423001212 DNA binding site [nucleotide binding] 326423001213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423001214 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326423001215 dimerization interface [polypeptide binding]; other site 326423001216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423001217 dimer interface [polypeptide binding]; other site 326423001218 phosphorylation site [posttranslational modification] 326423001219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423001220 ATP binding site [chemical binding]; other site 326423001221 Mg2+ binding site [ion binding]; other site 326423001222 G-X-G motif; other site 326423001223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 326423001224 binding surface 326423001225 TPR motif; other site 326423001226 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423001227 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423001228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326423001229 TPR motif; other site 326423001230 binding surface 326423001231 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423001232 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 326423001233 aspartate kinase; Reviewed; Region: PRK09034 326423001234 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 326423001235 putative catalytic residues [active] 326423001236 putative nucleotide binding site [chemical binding]; other site 326423001237 putative aspartate binding site [chemical binding]; other site 326423001238 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 326423001239 allosteric regulatory residue; other site 326423001240 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 326423001241 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 326423001242 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 326423001243 ABC-ATPase subunit interface; other site 326423001244 dimer interface [polypeptide binding]; other site 326423001245 putative PBP binding regions; other site 326423001246 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 326423001247 ABC-ATPase subunit interface; other site 326423001248 dimer interface [polypeptide binding]; other site 326423001249 putative PBP binding regions; other site 326423001250 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 326423001251 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 326423001252 Walker A/P-loop; other site 326423001253 ATP binding site [chemical binding]; other site 326423001254 Q-loop/lid; other site 326423001255 ABC transporter signature motif; other site 326423001256 Walker B; other site 326423001257 D-loop; other site 326423001258 H-loop/switch region; other site 326423001259 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 326423001260 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 326423001261 putative ligand binding residues [chemical binding]; other site 326423001262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423001263 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423001264 putative substrate translocation pore; other site 326423001265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423001266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423001267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423001268 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 326423001269 dimer interface [polypeptide binding]; other site 326423001270 FMN binding site [chemical binding]; other site 326423001271 NADPH bind site [chemical binding]; other site 326423001272 Uncharacterized conserved protein [Function unknown]; Region: COG1359 326423001273 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326423001274 dimerization interface [polypeptide binding]; other site 326423001275 putative DNA binding site [nucleotide binding]; other site 326423001276 putative Zn2+ binding site [ion binding]; other site 326423001277 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 326423001278 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423001279 DNA-binding site [nucleotide binding]; DNA binding site 326423001280 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326423001281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423001282 homodimer interface [polypeptide binding]; other site 326423001283 catalytic residue [active] 326423001284 4-aminobutyrate aminotransferase, prokaryotic type; Region: GABAtrnsam; TIGR00700 326423001285 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326423001286 inhibitor-cofactor binding pocket; inhibition site 326423001287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423001288 catalytic residue [active] 326423001289 succinic semialdehyde dehydrogenase; Region: PLN02278 326423001290 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 326423001291 tetramerization interface [polypeptide binding]; other site 326423001292 NAD(P) binding site [chemical binding]; other site 326423001293 catalytic residues [active] 326423001294 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 326423001295 glucose-1-dehydrogenase; Provisional; Region: PRK08936 326423001296 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 326423001297 NAD binding site [chemical binding]; other site 326423001298 homodimer interface [polypeptide binding]; other site 326423001299 active site 326423001300 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 326423001301 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 326423001302 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 326423001303 YtkA-like; Region: YtkA; pfam13115 326423001304 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 326423001305 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 326423001306 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 326423001307 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 326423001308 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 326423001309 active site 326423001310 P-loop; other site 326423001311 phosphorylation site [posttranslational modification] 326423001312 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 326423001313 active site 326423001314 phosphorylation site [posttranslational modification] 326423001315 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 326423001316 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 326423001317 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 326423001318 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 326423001319 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 326423001320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423001321 active site 326423001322 motif I; other site 326423001323 motif II; other site 326423001324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423001325 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 326423001326 putative active site [active] 326423001327 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 326423001328 hypothetical protein; Provisional; Region: PRK05463 326423001329 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 326423001330 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 326423001331 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 326423001332 Transcriptional regulator [Transcription]; Region: IclR; COG1414 326423001333 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 326423001334 Bacterial transcriptional regulator; Region: IclR; pfam01614 326423001335 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 326423001336 active site 326423001337 catalytic triad [active] 326423001338 oxyanion hole [active] 326423001339 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 326423001340 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 326423001341 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 326423001342 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 326423001343 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 326423001344 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326423001345 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326423001346 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326423001347 active site 326423001348 catalytic tetrad [active] 326423001349 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 326423001350 HTH domain; Region: HTH_11; pfam08279 326423001351 Mga helix-turn-helix domain; Region: Mga; pfam05043 326423001352 PRD domain; Region: PRD; pfam00874 326423001353 PRD domain; Region: PRD; pfam00874 326423001354 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 326423001355 active site 326423001356 P-loop; other site 326423001357 phosphorylation site [posttranslational modification] 326423001358 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 326423001359 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 326423001360 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 326423001361 acyl-activating enzyme (AAE) consensus motif; other site 326423001362 putative AMP binding site [chemical binding]; other site 326423001363 putative active site [active] 326423001364 putative CoA binding site [chemical binding]; other site 326423001365 short chain dehydrogenase; Provisional; Region: PRK06701 326423001366 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 326423001367 NAD binding site [chemical binding]; other site 326423001368 metal binding site [ion binding]; metal-binding site 326423001369 active site 326423001370 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 326423001371 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 326423001372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326423001373 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 326423001374 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 326423001375 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 326423001376 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 326423001377 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 326423001378 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 326423001379 putative DNA binding site [nucleotide binding]; other site 326423001380 putative Zn2+ binding site [ion binding]; other site 326423001381 AsnC family; Region: AsnC_trans_reg; pfam01037 326423001382 DNA topoisomerase III; Provisional; Region: PRK07726 326423001383 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 326423001384 active site 326423001385 putative interdomain interaction site [polypeptide binding]; other site 326423001386 putative metal-binding site [ion binding]; other site 326423001387 putative nucleotide binding site [chemical binding]; other site 326423001388 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 326423001389 domain I; other site 326423001390 DNA binding groove [nucleotide binding] 326423001391 phosphate binding site [ion binding]; other site 326423001392 domain II; other site 326423001393 domain III; other site 326423001394 nucleotide binding site [chemical binding]; other site 326423001395 catalytic site [active] 326423001396 domain IV; other site 326423001397 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 326423001398 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 326423001399 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 326423001400 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326423001401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326423001402 metal binding site [ion binding]; metal-binding site 326423001403 active site 326423001404 I-site; other site 326423001405 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 326423001406 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 326423001407 NodB motif; other site 326423001408 putative active site [active] 326423001409 putative catalytic site [active] 326423001410 putative Zn binding site [ion binding]; other site 326423001411 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 326423001412 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 326423001413 DXD motif; other site 326423001414 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 326423001415 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 326423001416 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 326423001417 nudix motif; other site 326423001418 pyruvate oxidase; Provisional; Region: PRK08611 326423001419 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 326423001420 PYR/PP interface [polypeptide binding]; other site 326423001421 dimer interface [polypeptide binding]; other site 326423001422 tetramer interface [polypeptide binding]; other site 326423001423 TPP binding site [chemical binding]; other site 326423001424 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 326423001425 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 326423001426 TPP-binding site [chemical binding]; other site 326423001427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423001428 Coenzyme A binding pocket [chemical binding]; other site 326423001429 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 326423001430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 326423001431 binding surface 326423001432 TPR motif; other site 326423001433 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423001434 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423001435 manganese transport protein MntH; Reviewed; Region: PRK00701 326423001436 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 326423001437 Bacterial SH3 domain; Region: SH3_3; cl17532 326423001438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 326423001439 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 326423001440 EcsC protein family; Region: EcsC; pfam12787 326423001441 General stress protein [General function prediction only]; Region: GsiB; COG3729 326423001442 General stress protein [General function prediction only]; Region: GsiB; COG3729 326423001443 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 326423001444 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 326423001445 dimanganese center [ion binding]; other site 326423001446 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 326423001447 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 326423001448 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 326423001449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326423001450 putative active site [active] 326423001451 heme pocket [chemical binding]; other site 326423001452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423001453 ATP binding site [chemical binding]; other site 326423001454 Mg2+ binding site [ion binding]; other site 326423001455 G-X-G motif; other site 326423001456 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 326423001457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423001458 active site 326423001459 phosphorylation site [posttranslational modification] 326423001460 intermolecular recognition site; other site 326423001461 dimerization interface [polypeptide binding]; other site 326423001462 HTH domain; Region: HTH_11; pfam08279 326423001463 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 326423001464 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 326423001465 Domain of unknown function DUF20; Region: UPF0118; pfam01594 326423001466 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 326423001467 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326423001468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326423001469 Walker A/P-loop; other site 326423001470 ATP binding site [chemical binding]; other site 326423001471 Q-loop/lid; other site 326423001472 ABC transporter signature motif; other site 326423001473 Walker B; other site 326423001474 D-loop; other site 326423001475 H-loop/switch region; other site 326423001476 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 326423001477 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 326423001478 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326423001479 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326423001480 active site 326423001481 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 326423001482 Cation efflux family; Region: Cation_efflux; cl00316 326423001483 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 326423001484 Cation efflux family; Region: Cation_efflux; cl00316 326423001485 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 326423001486 catalytic residues [active] 326423001487 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 326423001488 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 326423001489 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 326423001490 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 326423001491 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 326423001492 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326423001493 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326423001494 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 326423001495 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 326423001496 ATP binding site [chemical binding]; other site 326423001497 Mg++ binding site [ion binding]; other site 326423001498 motif III; other site 326423001499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326423001500 nucleotide binding region [chemical binding]; other site 326423001501 ATP-binding site [chemical binding]; other site 326423001502 Uncharacterized conserved protein [Function unknown]; Region: COG3402 326423001503 Predicted membrane protein [Function unknown]; Region: COG3428 326423001504 Bacterial PH domain; Region: DUF304; pfam03703 326423001505 Bacterial PH domain; Region: DUF304; pfam03703 326423001506 Bacterial PH domain; Region: DUF304; pfam03703 326423001507 Rhomboid family; Region: Rhomboid; pfam01694 326423001508 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 326423001509 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 326423001510 alanine racemase; Region: alr; TIGR00492 326423001511 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 326423001512 active site 326423001513 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 326423001514 dimer interface [polypeptide binding]; other site 326423001515 substrate binding site [chemical binding]; other site 326423001516 catalytic residues [active] 326423001517 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 326423001518 ribbon-helix-helix domain containing protein; Region: PHA00617 326423001519 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 326423001520 Rsbr N terminal; Region: Rsbr_N; pfam08678 326423001521 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 326423001522 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 326423001523 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 326423001524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423001525 ATP binding site [chemical binding]; other site 326423001526 Mg2+ binding site [ion binding]; other site 326423001527 G-X-G motif; other site 326423001528 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 326423001529 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 326423001530 CoA binding domain; Region: CoA_binding; cl17356 326423001531 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 326423001532 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 326423001533 anti sigma factor interaction site; other site 326423001534 regulatory phosphorylation site [posttranslational modification]; other site 326423001535 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 326423001536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423001537 ATP binding site [chemical binding]; other site 326423001538 Mg2+ binding site [ion binding]; other site 326423001539 G-X-G motif; other site 326423001540 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 326423001541 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326423001542 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 326423001543 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423001544 DNA binding residues [nucleotide binding] 326423001545 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 326423001546 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 326423001547 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 326423001548 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 326423001549 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 326423001550 RNA binding site [nucleotide binding]; other site 326423001551 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 326423001552 hypothetical protein; Provisional; Region: PRK04351 326423001553 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 326423001554 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 326423001555 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 326423001556 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 326423001557 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 326423001558 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 326423001559 AsnC family; Region: AsnC_trans_reg; pfam01037 326423001560 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326423001561 BCCT family transporter; Region: BCCT; cl00569 326423001562 proline/glycine betaine transporter; Provisional; Region: PRK10642 326423001563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423001564 putative substrate translocation pore; other site 326423001565 MarR family; Region: MarR_2; cl17246 326423001566 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 326423001567 putative active site [active] 326423001568 putative catalytic site [active] 326423001569 Protein of unknown function (DUF419); Region: DUF419; pfam04237 326423001570 Predicted transcriptional regulator [Transcription]; Region: COG1959 326423001571 Transcriptional regulator; Region: Rrf2; pfam02082 326423001572 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 326423001573 NADH(P)-binding; Region: NAD_binding_10; pfam13460 326423001574 NAD binding site [chemical binding]; other site 326423001575 substrate binding site [chemical binding]; other site 326423001576 putative active site [active] 326423001577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423001578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423001579 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 326423001580 classical (c) SDRs; Region: SDR_c; cd05233 326423001581 NAD(P) binding site [chemical binding]; other site 326423001582 active site 326423001583 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 326423001584 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 326423001585 putative NAD(P) binding site [chemical binding]; other site 326423001586 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 326423001587 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 326423001588 putative NAD(P) binding site [chemical binding]; other site 326423001589 Predicted transcriptional regulators [Transcription]; Region: COG1733 326423001590 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326423001591 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 326423001592 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 326423001593 putative di-iron ligands [ion binding]; other site 326423001594 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 326423001595 DNA-binding site [nucleotide binding]; DNA binding site 326423001596 RNA-binding motif; other site 326423001597 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 326423001598 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 326423001599 putative homodimer interface [polypeptide binding]; other site 326423001600 putative homotetramer interface [polypeptide binding]; other site 326423001601 putative metal binding site [ion binding]; other site 326423001602 putative homodimer-homodimer interface [polypeptide binding]; other site 326423001603 putative allosteric switch controlling residues; other site 326423001604 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 326423001605 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 326423001606 active site residue [active] 326423001607 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 326423001608 CPxP motif; other site 326423001609 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 326423001610 active site residue [active] 326423001611 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 326423001612 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326423001613 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 326423001614 CPxP motif; other site 326423001615 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 326423001616 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 326423001617 aspartate racemase; Region: asp_race; TIGR00035 326423001618 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 326423001619 Predicted transcriptional regulators [Transcription]; Region: COG1695 326423001620 Transcriptional regulator PadR-like family; Region: PadR; cl17335 326423001621 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326423001622 MarR family; Region: MarR; pfam01047 326423001623 MarR family; Region: MarR_2; cl17246 326423001624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423001625 Coenzyme A binding pocket [chemical binding]; other site 326423001626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423001627 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423001628 putative substrate translocation pore; other site 326423001629 Patatin [General function prediction only]; Region: COG3621 326423001630 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 326423001631 active site 326423001632 nucleophile elbow; other site 326423001633 DinB family; Region: DinB; cl17821 326423001634 DinB superfamily; Region: DinB_2; pfam12867 326423001635 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 326423001636 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 326423001637 FAD binding domain; Region: FAD_binding_4; pfam01565 326423001638 Berberine and berberine like; Region: BBE; pfam08031 326423001639 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326423001640 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 326423001641 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 326423001642 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 326423001643 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 326423001644 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 326423001645 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 326423001646 DinB superfamily; Region: DinB_2; pfam12867 326423001647 Protein of unknown function (DUF664); Region: DUF664; pfam04978 326423001648 N-acetylneuraminate lyase; Region: nanA; TIGR00683 326423001649 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 326423001650 inhibitor site; inhibition site 326423001651 active site 326423001652 dimer interface [polypeptide binding]; other site 326423001653 catalytic residue [active] 326423001654 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 326423001655 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326423001656 FeS/SAM binding site; other site 326423001657 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 326423001658 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 326423001659 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 326423001660 dimerization interface [polypeptide binding]; other site 326423001661 active site 326423001662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423001663 S-adenosylmethionine binding site [chemical binding]; other site 326423001664 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 326423001665 dimer interface [polypeptide binding]; other site 326423001666 substrate binding site [chemical binding]; other site 326423001667 ATP binding site [chemical binding]; other site 326423001668 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 326423001669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423001670 active site 326423001671 motif I; other site 326423001672 motif II; other site 326423001673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423001674 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 326423001675 nudix motif; other site 326423001676 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 326423001677 Sodium Bile acid symporter family; Region: SBF; cl17470 326423001678 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 326423001679 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 326423001680 putative NAD(P) binding site [chemical binding]; other site 326423001681 putative substrate binding site [chemical binding]; other site 326423001682 catalytic Zn binding site [ion binding]; other site 326423001683 structural Zn binding site [ion binding]; other site 326423001684 dimer interface [polypeptide binding]; other site 326423001685 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 326423001686 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 326423001687 DNA binding residues [nucleotide binding] 326423001688 putative dimer interface [polypeptide binding]; other site 326423001689 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 326423001690 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 326423001691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423001692 DNA-binding site [nucleotide binding]; DNA binding site 326423001693 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326423001694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423001695 homodimer interface [polypeptide binding]; other site 326423001696 catalytic residue [active] 326423001697 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 326423001698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326423001699 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423001700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423001701 active site 326423001702 phosphorylation site [posttranslational modification] 326423001703 intermolecular recognition site; other site 326423001704 dimerization interface [polypeptide binding]; other site 326423001705 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423001706 DNA binding site [nucleotide binding] 326423001707 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423001708 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326423001709 dimerization interface [polypeptide binding]; other site 326423001710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423001711 dimer interface [polypeptide binding]; other site 326423001712 phosphorylation site [posttranslational modification] 326423001713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423001714 ATP binding site [chemical binding]; other site 326423001715 Mg2+ binding site [ion binding]; other site 326423001716 G-X-G motif; other site 326423001717 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 326423001718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423001719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423001720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423001721 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 326423001722 EamA-like transporter family; Region: EamA; cl17759 326423001723 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 326423001724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423001725 DNA-binding site [nucleotide binding]; DNA binding site 326423001726 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326423001727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423001728 homodimer interface [polypeptide binding]; other site 326423001729 catalytic residue [active] 326423001730 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 326423001731 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 326423001732 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 326423001733 NAD binding site [chemical binding]; other site 326423001734 catalytic Zn binding site [ion binding]; other site 326423001735 structural Zn binding site [ion binding]; other site 326423001736 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 326423001737 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326423001738 Histidine kinase; Region: HisKA_3; pfam07730 326423001739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423001740 ATP binding site [chemical binding]; other site 326423001741 Mg2+ binding site [ion binding]; other site 326423001742 G-X-G motif; other site 326423001743 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326423001744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423001745 active site 326423001746 phosphorylation site [posttranslational modification] 326423001747 intermolecular recognition site; other site 326423001748 dimerization interface [polypeptide binding]; other site 326423001749 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326423001750 DNA binding residues [nucleotide binding] 326423001751 dimerization interface [polypeptide binding]; other site 326423001752 MMPL family; Region: MMPL; pfam03176 326423001753 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 326423001754 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 326423001755 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 326423001756 catalytic triad [active] 326423001757 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 326423001758 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326423001759 ABC transporter; Region: ABC_tran_2; pfam12848 326423001760 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326423001761 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326423001762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423001763 Coenzyme A binding pocket [chemical binding]; other site 326423001764 Uncharacterized conserved protein [Function unknown]; Region: COG1284 326423001765 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423001766 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423001767 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 326423001768 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 326423001769 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 326423001770 dimer interface [polypeptide binding]; other site 326423001771 active site 326423001772 metal binding site [ion binding]; metal-binding site 326423001773 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 326423001774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423001775 putative substrate translocation pore; other site 326423001776 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 326423001777 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 326423001778 dimer interface [polypeptide binding]; other site 326423001779 active site 326423001780 Helix-turn-helix domain; Region: HTH_31; pfam13560 326423001781 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 326423001782 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 326423001783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423001784 Coenzyme A binding pocket [chemical binding]; other site 326423001785 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 326423001786 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326423001787 DNA binding residues [nucleotide binding] 326423001788 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 326423001789 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 326423001790 EamA-like transporter family; Region: EamA; pfam00892 326423001791 EamA-like transporter family; Region: EamA; pfam00892 326423001792 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 326423001793 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 326423001794 nudix motif; other site 326423001795 Methyltransferase domain; Region: Methyltransf_31; pfam13847 326423001796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423001797 S-adenosylmethionine binding site [chemical binding]; other site 326423001798 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 326423001799 Transcriptional regulators [Transcription]; Region: GntR; COG1802 326423001800 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423001801 DNA-binding site [nucleotide binding]; DNA binding site 326423001802 FCD domain; Region: FCD; pfam07729 326423001803 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 326423001804 glycosyltransferase, MGT family; Region: MGT; TIGR01426 326423001805 active site 326423001806 TDP-binding site; other site 326423001807 acceptor substrate-binding pocket; other site 326423001808 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 326423001809 Beta-lactamase; Region: Beta-lactamase; pfam00144 326423001810 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 326423001811 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 326423001812 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 326423001813 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 326423001814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423001815 putative substrate translocation pore; other site 326423001816 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 326423001817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423001818 DNA-binding site [nucleotide binding]; DNA binding site 326423001819 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 326423001820 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326423001821 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423001822 DNA-binding site [nucleotide binding]; DNA binding site 326423001823 FCD domain; Region: FCD; pfam07729 326423001824 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 326423001825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423001826 putative substrate translocation pore; other site 326423001827 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 326423001828 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 326423001829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423001830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423001831 amino acid transporter; Region: 2A0306; TIGR00909 326423001832 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 326423001833 dimanganese center [ion binding]; other site 326423001834 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 326423001835 putative hydrophobic ligand binding site [chemical binding]; other site 326423001836 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 326423001837 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 326423001838 putative NADP binding site [chemical binding]; other site 326423001839 putative dimer interface [polypeptide binding]; other site 326423001840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423001841 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 326423001842 putative substrate translocation pore; other site 326423001843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423001844 thiamine monophosphate kinase; Provisional; Region: PRK05731 326423001845 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 326423001846 ATP binding site [chemical binding]; other site 326423001847 dimerization interface [polypeptide binding]; other site 326423001848 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 326423001849 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 326423001850 Glycoprotease family; Region: Peptidase_M22; pfam00814 326423001851 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 326423001852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423001853 Coenzyme A binding pocket [chemical binding]; other site 326423001854 UGMP family protein; Validated; Region: PRK09604 326423001855 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 326423001856 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 326423001857 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 326423001858 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326423001859 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326423001860 ABC transporter; Region: ABC_tran_2; pfam12848 326423001861 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326423001862 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 326423001863 trimer interface [polypeptide binding]; other site 326423001864 dimer interface [polypeptide binding]; other site 326423001865 putative active site [active] 326423001866 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 326423001867 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 326423001868 CoA binding domain; Region: CoA_binding; pfam02629 326423001869 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 326423001870 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 326423001871 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 326423001872 CAAX protease self-immunity; Region: Abi; pfam02517 326423001873 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 326423001874 oligomerisation interface [polypeptide binding]; other site 326423001875 mobile loop; other site 326423001876 roof hairpin; other site 326423001877 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 326423001878 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 326423001879 ring oligomerisation interface [polypeptide binding]; other site 326423001880 ATP/Mg binding site [chemical binding]; other site 326423001881 stacking interactions; other site 326423001882 hinge regions; other site 326423001883 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326423001884 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 326423001885 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326423001886 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 326423001887 active site 326423001888 NACHT domain; Region: NACHT; pfam05729 326423001889 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423001890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326423001891 binding surface 326423001892 TPR motif; other site 326423001893 TPR repeat; Region: TPR_11; pfam13414 326423001894 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 326423001895 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 326423001896 inhibitor binding site; inhibition site 326423001897 catalytic Zn binding site [ion binding]; other site 326423001898 structural Zn binding site [ion binding]; other site 326423001899 NADP binding site [chemical binding]; other site 326423001900 tetramer interface [polypeptide binding]; other site 326423001901 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 326423001902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423001903 putative substrate translocation pore; other site 326423001904 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326423001905 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 326423001906 putative substrate binding site [chemical binding]; other site 326423001907 putative ATP binding site [chemical binding]; other site 326423001908 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 326423001909 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 326423001910 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 326423001911 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 326423001912 Repair protein; Region: Repair_PSII; pfam04536 326423001913 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 326423001914 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 326423001915 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 326423001916 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 326423001917 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 326423001918 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 326423001919 catalytic triad [active] 326423001920 catalytic triad [active] 326423001921 oxyanion hole [active] 326423001922 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 326423001923 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 326423001924 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 326423001925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326423001926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423001927 DNA binding residues [nucleotide binding] 326423001928 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 326423001929 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 326423001930 putative NAD(P) binding site [chemical binding]; other site 326423001931 catalytic Zn binding site [ion binding]; other site 326423001932 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 326423001933 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 326423001934 Cold-inducible protein YdjO; Region: YdjO; pfam14169 326423001935 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 326423001936 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 326423001937 Multicopper oxidase; Region: Cu-oxidase; pfam00394 326423001938 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 326423001939 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 326423001940 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 326423001941 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 326423001942 MoxR-like ATPases [General function prediction only]; Region: COG0714 326423001943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423001944 Walker A motif; other site 326423001945 ATP binding site [chemical binding]; other site 326423001946 Walker B motif; other site 326423001947 arginine finger; other site 326423001948 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 326423001949 Protein of unknown function DUF58; Region: DUF58; pfam01882 326423001950 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 326423001951 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 326423001952 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 326423001953 GMP synthase; Reviewed; Region: guaA; PRK00074 326423001954 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 326423001955 AMP/PPi binding site [chemical binding]; other site 326423001956 candidate oxyanion hole; other site 326423001957 catalytic triad [active] 326423001958 potential glutamine specificity residues [chemical binding]; other site 326423001959 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 326423001960 ATP Binding subdomain [chemical binding]; other site 326423001961 Ligand Binding sites [chemical binding]; other site 326423001962 Dimerization subdomain; other site 326423001963 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 326423001964 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326423001965 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423001966 DNA binding residues [nucleotide binding] 326423001967 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 326423001968 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 326423001969 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 326423001970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 326423001971 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 326423001972 NETI protein; Region: NETI; pfam14044 326423001973 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 326423001974 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 326423001975 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 326423001976 NAD binding site [chemical binding]; other site 326423001977 ATP-grasp domain; Region: ATP-grasp; pfam02222 326423001978 adenylosuccinate lyase; Provisional; Region: PRK07492 326423001979 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 326423001980 tetramer interface [polypeptide binding]; other site 326423001981 active site 326423001982 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 326423001983 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 326423001984 ATP binding site [chemical binding]; other site 326423001985 active site 326423001986 substrate binding site [chemical binding]; other site 326423001987 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 326423001988 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 326423001989 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 326423001990 putative active site [active] 326423001991 catalytic triad [active] 326423001992 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 326423001993 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 326423001994 dimerization interface [polypeptide binding]; other site 326423001995 ATP binding site [chemical binding]; other site 326423001996 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 326423001997 dimerization interface [polypeptide binding]; other site 326423001998 ATP binding site [chemical binding]; other site 326423001999 amidophosphoribosyltransferase; Provisional; Region: PRK07631 326423002000 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 326423002001 active site 326423002002 tetramer interface [polypeptide binding]; other site 326423002003 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326423002004 active site 326423002005 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 326423002006 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 326423002007 dimerization interface [polypeptide binding]; other site 326423002008 putative ATP binding site [chemical binding]; other site 326423002009 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 326423002010 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 326423002011 active site 326423002012 substrate binding site [chemical binding]; other site 326423002013 cosubstrate binding site; other site 326423002014 catalytic site [active] 326423002015 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 326423002016 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 326423002017 purine monophosphate binding site [chemical binding]; other site 326423002018 dimer interface [polypeptide binding]; other site 326423002019 putative catalytic residues [active] 326423002020 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 326423002021 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 326423002022 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 326423002023 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 326423002024 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 326423002025 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 326423002026 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326423002027 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 326423002028 active site 326423002029 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326423002030 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 326423002031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 326423002032 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 326423002033 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 326423002034 active site 326423002035 FMN binding site [chemical binding]; other site 326423002036 substrate binding site [chemical binding]; other site 326423002037 3Fe-4S cluster binding site [ion binding]; other site 326423002038 PcrB family; Region: PcrB; pfam01884 326423002039 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 326423002040 substrate binding site [chemical binding]; other site 326423002041 putative active site [active] 326423002042 dimer interface [polypeptide binding]; other site 326423002043 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 326423002044 Part of AAA domain; Region: AAA_19; pfam13245 326423002045 Family description; Region: UvrD_C_2; pfam13538 326423002046 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 326423002047 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 326423002048 nucleotide binding pocket [chemical binding]; other site 326423002049 K-X-D-G motif; other site 326423002050 catalytic site [active] 326423002051 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 326423002052 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 326423002053 Helix-hairpin-helix motif; Region: HHH; pfam00633 326423002054 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 326423002055 Dimer interface [polypeptide binding]; other site 326423002056 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 326423002057 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 326423002058 putative dimer interface [polypeptide binding]; other site 326423002059 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 326423002060 putative dimer interface [polypeptide binding]; other site 326423002061 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 326423002062 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326423002063 active site 326423002064 ATP binding site [chemical binding]; other site 326423002065 substrate binding site [chemical binding]; other site 326423002066 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 326423002067 MgtC family; Region: MgtC; pfam02308 326423002068 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 326423002069 Na binding site [ion binding]; other site 326423002070 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 326423002071 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 326423002072 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 326423002073 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 326423002074 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 326423002075 GatB domain; Region: GatB_Yqey; pfam02637 326423002076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423002077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423002078 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 326423002079 Protein export membrane protein; Region: SecD_SecF; cl14618 326423002080 putative lipid kinase; Reviewed; Region: PRK13337 326423002081 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 326423002082 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 326423002083 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 326423002084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423002085 S-adenosylmethionine binding site [chemical binding]; other site 326423002086 HsdM N-terminal domain; Region: HsdM_N; pfam12161 326423002087 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 326423002088 Methyltransferase domain; Region: Methyltransf_26; pfam13659 326423002089 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 326423002090 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 326423002091 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 326423002092 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 326423002093 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326423002094 ATP binding site [chemical binding]; other site 326423002095 putative Mg++ binding site [ion binding]; other site 326423002096 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 326423002097 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 326423002098 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 326423002099 active site 326423002100 Protein of unknown function, DUF600; Region: DUF600; cl04640 326423002101 Protein of unknown function, DUF600; Region: DUF600; cl04640 326423002102 Protein of unknown function, DUF600; Region: DUF600; pfam04634 326423002103 LXG domain of WXG superfamily; Region: LXG; pfam04740 326423002104 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 326423002105 hypothetical protein; Provisional; Region: PRK12378 326423002106 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 326423002107 CotJB protein; Region: CotJB; pfam12652 326423002108 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 326423002109 dimanganese center [ion binding]; other site 326423002110 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326423002111 Coenzyme A binding pocket [chemical binding]; other site 326423002112 YesK-like protein; Region: YesK; pfam14150 326423002113 Predicted membrane protein [Function unknown]; Region: COG2323 326423002114 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 326423002115 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326423002116 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 326423002117 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 326423002118 Uncharacterized small protein [Function unknown]; Region: COG5583 326423002119 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 326423002120 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 326423002121 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423002122 MarR family; Region: MarR; pfam01047 326423002123 hypothetical protein; Provisional; Region: PRK06847 326423002124 hypothetical protein; Provisional; Region: PRK07236 326423002125 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 326423002126 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 326423002127 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 326423002128 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326423002129 Cytochrome P450; Region: p450; pfam00067 326423002130 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 326423002131 Flavodoxin; Region: Flavodoxin_1; pfam00258 326423002132 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 326423002133 FAD binding pocket [chemical binding]; other site 326423002134 FAD binding motif [chemical binding]; other site 326423002135 catalytic residues [active] 326423002136 NAD binding pocket [chemical binding]; other site 326423002137 phosphate binding motif [ion binding]; other site 326423002138 beta-alpha-beta structure motif; other site 326423002139 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 326423002140 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326423002141 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326423002142 Walker A/P-loop; other site 326423002143 ATP binding site [chemical binding]; other site 326423002144 Q-loop/lid; other site 326423002145 ABC transporter signature motif; other site 326423002146 Walker B; other site 326423002147 D-loop; other site 326423002148 H-loop/switch region; other site 326423002149 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 326423002150 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 326423002151 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 326423002152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326423002153 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 326423002154 YcaO-like family; Region: YcaO; pfam02624 326423002155 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 326423002156 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 326423002157 putative FMN binding site [chemical binding]; other site 326423002158 NADPH bind site [chemical binding]; other site 326423002159 Methyltransferase domain; Region: Methyltransf_31; pfam13847 326423002160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423002161 S-adenosylmethionine binding site [chemical binding]; other site 326423002162 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 326423002163 Sulfatase; Region: Sulfatase; pfam00884 326423002164 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 326423002165 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 326423002166 substrate binding site; other site 326423002167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326423002168 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 326423002169 NAD(P) binding site [chemical binding]; other site 326423002170 active site 326423002171 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326423002172 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 326423002173 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326423002174 active site 326423002175 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 326423002176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423002177 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423002178 putative substrate translocation pore; other site 326423002179 amino acid transporter; Region: 2A0306; TIGR00909 326423002180 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 326423002181 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 326423002182 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 326423002183 NAD(P) binding site [chemical binding]; other site 326423002184 catalytic residues [active] 326423002185 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 326423002186 dimer interface [polypeptide binding]; other site 326423002187 putative CheW interface [polypeptide binding]; other site 326423002188 oxidoreductase; Provisional; Region: PRK07985 326423002189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326423002190 NAD(P) binding site [chemical binding]; other site 326423002191 active site 326423002192 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 326423002193 putative metal binding site; other site 326423002194 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 326423002195 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326423002196 Walker A/P-loop; other site 326423002197 ATP binding site [chemical binding]; other site 326423002198 Q-loop/lid; other site 326423002199 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326423002200 ABC transporter signature motif; other site 326423002201 Walker B; other site 326423002202 D-loop; other site 326423002203 ABC transporter; Region: ABC_tran_2; pfam12848 326423002204 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326423002205 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 326423002206 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 326423002207 DNA binding residues [nucleotide binding] 326423002208 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 326423002209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423002210 putative substrate translocation pore; other site 326423002211 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 326423002212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326423002213 Walker A/P-loop; other site 326423002214 ATP binding site [chemical binding]; other site 326423002215 Q-loop/lid; other site 326423002216 ABC transporter signature motif; other site 326423002217 Walker B; other site 326423002218 D-loop; other site 326423002219 H-loop/switch region; other site 326423002220 ABC transporter; Region: ABC_tran_2; pfam12848 326423002221 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326423002222 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 326423002223 DEAD-like helicases superfamily; Region: DEXDc; smart00487 326423002224 ATP binding site [chemical binding]; other site 326423002225 Mg++ binding site [ion binding]; other site 326423002226 motif III; other site 326423002227 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326423002228 nucleotide binding region [chemical binding]; other site 326423002229 ATP-binding site [chemical binding]; other site 326423002230 similar to hypothetical protein YfmK, contains internal stop 326423002231 Prostaglandin dehydrogenases; Region: PGDH; cd05288 326423002232 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 326423002233 NAD(P) binding site [chemical binding]; other site 326423002234 substrate binding site [chemical binding]; other site 326423002235 dimer interface [polypeptide binding]; other site 326423002236 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 326423002237 Heat induced stress protein YflT; Region: YflT; pfam11181 326423002238 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 326423002239 Amb_all domain; Region: Amb_all; smart00656 326423002240 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 326423002241 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 326423002242 transmembrane helices; other site 326423002243 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 326423002244 BclB C-terminal domain; Region: exospore_TM; TIGR03721 326423002245 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 326423002246 PAS domain; Region: PAS; smart00091 326423002247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423002248 ATP binding site [chemical binding]; other site 326423002249 Mg2+ binding site [ion binding]; other site 326423002250 G-X-G motif; other site 326423002251 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 326423002252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423002253 active site 326423002254 phosphorylation site [posttranslational modification] 326423002255 intermolecular recognition site; other site 326423002256 dimerization interface [polypeptide binding]; other site 326423002257 Transcriptional regulator; Region: CitT; pfam12431 326423002258 HTH domain; Region: HTH_11; cl17392 326423002259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 326423002260 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 326423002261 Citrate transporter; Region: CitMHS; pfam03600 326423002262 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326423002263 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 326423002264 active site 326423002265 dimer interface [polypeptide binding]; other site 326423002266 acylphosphatase; Provisional; Region: PRK14420 326423002267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 326423002268 MOSC domain; Region: MOSC; pfam03473 326423002269 3-alpha domain; Region: 3-alpha; pfam03475 326423002270 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 326423002271 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 326423002272 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 326423002273 active site 326423002274 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 326423002275 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 326423002276 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 326423002277 active site turn [active] 326423002278 phosphorylation site [posttranslational modification] 326423002279 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 326423002280 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 326423002281 Sulfatase; Region: Sulfatase; pfam00884 326423002282 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 326423002283 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 326423002284 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 326423002285 putative dimer interface [polypeptide binding]; other site 326423002286 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 326423002287 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 326423002288 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 326423002289 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 326423002290 active site turn [active] 326423002291 phosphorylation site [posttranslational modification] 326423002292 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 326423002293 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 326423002294 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 326423002295 Ca binding site [ion binding]; other site 326423002296 active site 326423002297 catalytic site [active] 326423002298 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 326423002299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423002300 DNA-binding site [nucleotide binding]; DNA binding site 326423002301 UTRA domain; Region: UTRA; pfam07702 326423002302 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 326423002303 dimer interface [polypeptide binding]; other site 326423002304 FMN binding site [chemical binding]; other site 326423002305 YibE/F-like protein; Region: YibE_F; pfam07907 326423002306 YibE/F-like protein; Region: YibE_F; pfam07907 326423002307 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 326423002308 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 326423002309 active site 326423002310 metal binding site [ion binding]; metal-binding site 326423002311 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 326423002312 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 326423002313 active site 326423002314 metal binding site [ion binding]; metal-binding site 326423002315 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 326423002316 intracellular protease, PfpI family; Region: PfpI; TIGR01382 326423002317 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 326423002318 proposed catalytic triad [active] 326423002319 conserved cys residue [active] 326423002320 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326423002321 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326423002322 DNA binding site [nucleotide binding] 326423002323 domain linker motif; other site 326423002324 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 326423002325 putative dimerization interface [polypeptide binding]; other site 326423002326 putative ligand binding site [chemical binding]; other site 326423002327 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 326423002328 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 326423002329 shikimate binding site; other site 326423002330 NAD(P) binding site [chemical binding]; other site 326423002331 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 326423002332 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 326423002333 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 326423002334 shikimate binding site; other site 326423002335 NAD(P) binding site [chemical binding]; other site 326423002336 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 326423002337 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 326423002338 active site 326423002339 catalytic residue [active] 326423002340 dimer interface [polypeptide binding]; other site 326423002341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423002342 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423002343 putative substrate translocation pore; other site 326423002344 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 326423002345 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 326423002346 Low molecular weight phosphatase family; Region: LMWPc; cd00115 326423002347 active site 326423002348 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 326423002349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423002350 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423002351 putative substrate translocation pore; other site 326423002352 calcium/proton exchanger (cax); Region: cax; TIGR00378 326423002353 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 326423002354 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 326423002355 YfkD-like protein; Region: YfkD; pfam14167 326423002356 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 326423002357 Mechanosensitive ion channel; Region: MS_channel; pfam00924 326423002358 Radical SAM superfamily; Region: Radical_SAM; pfam04055 326423002359 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326423002360 FeS/SAM binding site; other site 326423002361 YfkB-like domain; Region: YfkB; pfam08756 326423002362 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 326423002363 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 326423002364 NodB motif; other site 326423002365 active site 326423002366 catalytic site [active] 326423002367 Cd binding site [ion binding]; other site 326423002368 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 326423002369 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 326423002370 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 326423002371 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 326423002372 oligomer interface [polypeptide binding]; other site 326423002373 metal binding site [ion binding]; metal-binding site 326423002374 metal binding site [ion binding]; metal-binding site 326423002375 putative Cl binding site [ion binding]; other site 326423002376 aspartate ring; other site 326423002377 basic sphincter; other site 326423002378 hydrophobic gate; other site 326423002379 periplasmic entrance; other site 326423002380 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 326423002381 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 326423002382 minor groove reading motif; other site 326423002383 helix-hairpin-helix signature motif; other site 326423002384 substrate binding pocket [chemical binding]; other site 326423002385 active site 326423002386 TRAM domain; Region: TRAM; pfam01938 326423002387 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 326423002388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423002389 S-adenosylmethionine binding site [chemical binding]; other site 326423002390 YfzA-like protein; Region: YfzA; pfam14118 326423002391 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 326423002392 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 326423002393 FMN binding site [chemical binding]; other site 326423002394 active site 326423002395 catalytic residues [active] 326423002396 substrate binding site [chemical binding]; other site 326423002397 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 326423002398 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 326423002399 tetramer interface [polypeptide binding]; other site 326423002400 TPP-binding site [chemical binding]; other site 326423002401 heterodimer interface [polypeptide binding]; other site 326423002402 phosphorylation loop region [posttranslational modification] 326423002403 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 326423002404 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 326423002405 alpha subunit interface [polypeptide binding]; other site 326423002406 TPP binding site [chemical binding]; other site 326423002407 heterodimer interface [polypeptide binding]; other site 326423002408 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 326423002409 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 326423002410 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 326423002411 E3 interaction surface; other site 326423002412 lipoyl attachment site [posttranslational modification]; other site 326423002413 e3 binding domain; Region: E3_binding; pfam02817 326423002414 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 326423002415 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 326423002416 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326423002417 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 326423002418 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 326423002419 GAF domain; Region: GAF; pfam01590 326423002420 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423002421 Walker A motif; other site 326423002422 ATP binding site [chemical binding]; other site 326423002423 Walker B motif; other site 326423002424 arginine finger; other site 326423002425 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 326423002426 Small acid-soluble spore protein H family; Region: SspH; pfam08141 326423002427 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 326423002428 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 326423002429 NAD binding site [chemical binding]; other site 326423002430 sugar binding site [chemical binding]; other site 326423002431 divalent metal binding site [ion binding]; other site 326423002432 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 326423002433 dimer interface [polypeptide binding]; other site 326423002434 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 326423002435 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 326423002436 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 326423002437 putative active site [active] 326423002438 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 326423002439 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 326423002440 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 326423002441 active site turn [active] 326423002442 phosphorylation site [posttranslational modification] 326423002443 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 326423002444 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 326423002445 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326423002446 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326423002447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326423002448 Walker A/P-loop; other site 326423002449 ATP binding site [chemical binding]; other site 326423002450 Q-loop/lid; other site 326423002451 ABC transporter signature motif; other site 326423002452 Walker B; other site 326423002453 D-loop; other site 326423002454 H-loop/switch region; other site 326423002455 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326423002456 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326423002457 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 326423002458 Walker A/P-loop; other site 326423002459 ATP binding site [chemical binding]; other site 326423002460 Q-loop/lid; other site 326423002461 ABC transporter signature motif; other site 326423002462 Walker B; other site 326423002463 D-loop; other site 326423002464 H-loop/switch region; other site 326423002465 Predicted membrane protein [Function unknown]; Region: COG2259 326423002466 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 326423002467 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 326423002468 putative metal binding site [ion binding]; other site 326423002469 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 326423002470 active site 326423002471 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 326423002472 UbiA prenyltransferase family; Region: UbiA; pfam01040 326423002473 Predicted transcriptional regulators [Transcription]; Region: COG1695 326423002474 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 326423002475 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 326423002476 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 326423002477 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 326423002478 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 326423002479 Acyltransferase family; Region: Acyl_transf_3; pfam01757 326423002480 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 326423002481 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 326423002482 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 326423002483 RNAase interaction site [polypeptide binding]; other site 326423002484 metal-dependent hydrolase; Provisional; Region: PRK13291 326423002485 DinB superfamily; Region: DinB_2; pfam12867 326423002486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423002487 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423002488 putative substrate translocation pore; other site 326423002489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423002490 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423002491 MarR family; Region: MarR; pfam01047 326423002492 Predicted integral membrane protein [Function unknown]; Region: COG0392 326423002493 Uncharacterized conserved protein [Function unknown]; Region: COG2898 326423002494 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 326423002495 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 326423002496 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 326423002497 putative FMN binding site [chemical binding]; other site 326423002498 YfhD-like protein; Region: YfhD; pfam14151 326423002499 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 326423002500 TIGR01777 family protein; Region: yfcH 326423002501 putative NAD(P) binding site [chemical binding]; other site 326423002502 putative active site [active] 326423002503 recombination regulator RecX; Provisional; Region: recX; PRK14135 326423002504 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 326423002505 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 326423002506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423002507 putative substrate translocation pore; other site 326423002508 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 326423002509 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 326423002510 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 326423002511 WVELL protein; Region: WVELL; pfam14043 326423002512 Bacterial SH3 domain homologues; Region: SH3b; smart00287 326423002513 Bacterial SH3 domain; Region: SH3_3; cl17532 326423002514 SdpI/YhfL protein family; Region: SdpI; pfam13630 326423002515 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326423002516 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326423002517 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 326423002518 Ligand binding site; other site 326423002519 Putative Catalytic site; other site 326423002520 DXD motif; other site 326423002521 Predicted membrane protein [Function unknown]; Region: COG4485 326423002522 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 326423002523 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 326423002524 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 326423002525 minor groove reading motif; other site 326423002526 helix-hairpin-helix signature motif; other site 326423002527 substrate binding pocket [chemical binding]; other site 326423002528 active site 326423002529 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 326423002530 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 326423002531 DNA binding and oxoG recognition site [nucleotide binding] 326423002532 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 326423002533 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 326423002534 putative NAD(P) binding site [chemical binding]; other site 326423002535 active site 326423002536 YgaB-like protein; Region: YgaB; pfam14182 326423002537 hypothetical protein; Provisional; Region: PRK13662 326423002538 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326423002539 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326423002540 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 326423002541 Walker A/P-loop; other site 326423002542 ATP binding site [chemical binding]; other site 326423002543 Q-loop/lid; other site 326423002544 ABC transporter signature motif; other site 326423002545 Walker B; other site 326423002546 D-loop; other site 326423002547 H-loop/switch region; other site 326423002548 Predicted membrane protein [Function unknown]; Region: COG4129 326423002549 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 326423002550 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 326423002551 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326423002552 inhibitor-cofactor binding pocket; inhibition site 326423002553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423002554 catalytic residue [active] 326423002555 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 326423002556 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 326423002557 catalytic triad [active] 326423002558 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 326423002559 metal binding site 2 [ion binding]; metal-binding site 326423002560 putative DNA binding helix; other site 326423002561 metal binding site 1 [ion binding]; metal-binding site 326423002562 dimer interface [polypeptide binding]; other site 326423002563 structural Zn2+ binding site [ion binding]; other site 326423002564 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 326423002565 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 326423002566 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 326423002567 active site pocket [active] 326423002568 oxyanion hole [active] 326423002569 catalytic triad [active] 326423002570 active site nucleophile [active] 326423002571 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 326423002572 ThiC-associated domain; Region: ThiC-associated; pfam13667 326423002573 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 326423002574 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 326423002575 FAD binding domain; Region: FAD_binding_4; pfam01565 326423002576 Berberine and berberine like; Region: BBE; pfam08031 326423002577 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 326423002578 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 326423002579 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 326423002580 tetramer interface [polypeptide binding]; other site 326423002581 heme binding pocket [chemical binding]; other site 326423002582 NADPH binding site [chemical binding]; other site 326423002583 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 326423002584 active site 326423002585 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 326423002586 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 326423002587 Walker A/P-loop; other site 326423002588 ATP binding site [chemical binding]; other site 326423002589 Q-loop/lid; other site 326423002590 ABC transporter signature motif; other site 326423002591 Walker B; other site 326423002592 D-loop; other site 326423002593 H-loop/switch region; other site 326423002594 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 326423002595 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326423002596 substrate binding pocket [chemical binding]; other site 326423002597 membrane-bound complex binding site; other site 326423002598 hinge residues; other site 326423002599 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 326423002600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423002601 dimer interface [polypeptide binding]; other site 326423002602 conserved gate region; other site 326423002603 putative PBP binding loops; other site 326423002604 ABC-ATPase subunit interface; other site 326423002605 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 326423002606 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 326423002607 active site 326423002608 dimer interface [polypeptide binding]; other site 326423002609 non-prolyl cis peptide bond; other site 326423002610 insertion regions; other site 326423002611 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 326423002612 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 326423002613 epoxyqueuosine reductase; Region: TIGR00276 326423002614 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 326423002615 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 326423002616 Putative amidase domain; Region: Amidase_6; pfam12671 326423002617 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 326423002618 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 326423002619 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 326423002620 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 326423002621 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 326423002622 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 326423002623 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 326423002624 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 326423002625 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423002626 MarR family; Region: MarR; pfam01047 326423002627 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 326423002628 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 326423002629 carboxyltransferase (CT) interaction site; other site 326423002630 biotinylation site [posttranslational modification]; other site 326423002631 HlyD family secretion protein; Region: HlyD_3; pfam13437 326423002632 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326423002633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423002634 putative substrate translocation pore; other site 326423002635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423002636 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 326423002637 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 326423002638 Predicted transcriptional regulators [Transcription]; Region: COG1725 326423002639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423002640 DNA-binding site [nucleotide binding]; DNA binding site 326423002641 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326423002642 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 326423002643 Walker A/P-loop; other site 326423002644 ATP binding site [chemical binding]; other site 326423002645 Q-loop/lid; other site 326423002646 ABC transporter signature motif; other site 326423002647 Walker B; other site 326423002648 D-loop; other site 326423002649 H-loop/switch region; other site 326423002650 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326423002651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326423002652 Walker A/P-loop; other site 326423002653 ATP binding site [chemical binding]; other site 326423002654 Q-loop/lid; other site 326423002655 ABC transporter signature motif; other site 326423002656 Walker B; other site 326423002657 D-loop; other site 326423002658 H-loop/switch region; other site 326423002659 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 326423002660 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 326423002661 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 326423002662 DNA-binding site [nucleotide binding]; DNA binding site 326423002663 RNA-binding motif; other site 326423002664 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 326423002665 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 326423002666 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 326423002667 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326423002668 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326423002669 metal binding site [ion binding]; metal-binding site 326423002670 active site 326423002671 I-site; other site 326423002672 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 326423002673 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 326423002674 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 326423002675 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 326423002676 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 326423002677 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 326423002678 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 326423002679 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 326423002680 putative active site [active] 326423002681 putative metal binding site [ion binding]; other site 326423002682 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 326423002683 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 326423002684 active site 326423002685 catalytic site [active] 326423002686 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 326423002687 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 326423002688 active site 326423002689 FOG: CBS domain [General function prediction only]; Region: COG0517 326423002690 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 326423002691 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 326423002692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423002693 motif II; other site 326423002694 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 326423002695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423002696 Coenzyme A binding pocket [chemical binding]; other site 326423002697 Predicted amidohydrolase [General function prediction only]; Region: COG0388 326423002698 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 326423002699 putative active site [active] 326423002700 catalytic triad [active] 326423002701 putative dimer interface [polypeptide binding]; other site 326423002702 aminotransferase; Validated; Region: PRK07678 326423002703 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326423002704 inhibitor-cofactor binding pocket; inhibition site 326423002705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423002706 catalytic residue [active] 326423002707 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 326423002708 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 326423002709 amphipathic channel; other site 326423002710 Asn-Pro-Ala signature motifs; other site 326423002711 glycerol kinase; Provisional; Region: glpK; PRK00047 326423002712 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 326423002713 N- and C-terminal domain interface [polypeptide binding]; other site 326423002714 active site 326423002715 MgATP binding site [chemical binding]; other site 326423002716 catalytic site [active] 326423002717 metal binding site [ion binding]; metal-binding site 326423002718 glycerol binding site [chemical binding]; other site 326423002719 homotetramer interface [polypeptide binding]; other site 326423002720 homodimer interface [polypeptide binding]; other site 326423002721 FBP binding site [chemical binding]; other site 326423002722 protein IIAGlc interface [polypeptide binding]; other site 326423002723 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 326423002724 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 326423002725 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 326423002726 active site 326423002727 substrate binding site [chemical binding]; other site 326423002728 metal binding site [ion binding]; metal-binding site 326423002729 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 326423002730 GAF domain; Region: GAF; pfam01590 326423002731 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326423002732 Histidine kinase; Region: HisKA_3; pfam07730 326423002733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423002734 ATP binding site [chemical binding]; other site 326423002735 Mg2+ binding site [ion binding]; other site 326423002736 G-X-G motif; other site 326423002737 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326423002738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423002739 active site 326423002740 phosphorylation site [posttranslational modification] 326423002741 intermolecular recognition site; other site 326423002742 dimerization interface [polypeptide binding]; other site 326423002743 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326423002744 DNA binding residues [nucleotide binding] 326423002745 dimerization interface [polypeptide binding]; other site 326423002746 Predicted flavoprotein [General function prediction only]; Region: COG0431 326423002747 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 326423002748 YhdB-like protein; Region: YhdB; pfam14148 326423002749 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 326423002750 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423002751 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423002752 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 326423002753 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423002754 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423002755 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423002756 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326423002757 NlpC/P60 family; Region: NLPC_P60; pfam00877 326423002758 Transcriptional regulator; Region: Rrf2; cl17282 326423002759 Rrf2 family protein; Region: rrf2_super; TIGR00738 326423002760 Conserved TM helix; Region: TM_helix; pfam05552 326423002761 Conserved TM helix; Region: TM_helix; pfam05552 326423002762 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 326423002763 SpoVR like protein; Region: SpoVR; pfam04293 326423002764 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 326423002765 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 326423002766 dimer interface [polypeptide binding]; other site 326423002767 active site 326423002768 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423002769 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423002770 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326423002771 NlpC/P60 family; Region: NLPC_P60; pfam00877 326423002772 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423002773 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423002774 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326423002775 dimerization interface [polypeptide binding]; other site 326423002776 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 326423002777 dimer interface [polypeptide binding]; other site 326423002778 Citrate synthase; Region: Citrate_synt; pfam00285 326423002779 active site 326423002780 citrylCoA binding site [chemical binding]; other site 326423002781 oxalacetate/citrate binding site [chemical binding]; other site 326423002782 coenzyme A binding site [chemical binding]; other site 326423002783 catalytic triad [active] 326423002784 short chain dehydrogenase; Provisional; Region: PRK06701 326423002785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326423002786 NAD(P) binding site [chemical binding]; other site 326423002787 active site 326423002788 amino acid transporter; Region: 2A0306; TIGR00909 326423002789 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 326423002790 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 326423002791 Na2 binding site [ion binding]; other site 326423002792 putative substrate binding site 1 [chemical binding]; other site 326423002793 Na binding site 1 [ion binding]; other site 326423002794 putative substrate binding site 2 [chemical binding]; other site 326423002795 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 326423002796 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 326423002797 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 326423002798 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326423002799 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423002800 DNA binding residues [nucleotide binding] 326423002801 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 326423002802 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 326423002803 putative acyl-acceptor binding pocket; other site 326423002804 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 326423002805 Domain of unknown function DUF21; Region: DUF21; pfam01595 326423002806 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 326423002807 Transporter associated domain; Region: CorC_HlyC; smart01091 326423002808 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 326423002809 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326423002810 DNA binding residues [nucleotide binding] 326423002811 putative dimer interface [polypeptide binding]; other site 326423002812 aspartate aminotransferase; Provisional; Region: PRK06836 326423002813 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326423002814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423002815 homodimer interface [polypeptide binding]; other site 326423002816 catalytic residue [active] 326423002817 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 326423002818 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 326423002819 dimer interface [polypeptide binding]; other site 326423002820 active site 326423002821 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 326423002822 Domain of unknown function DUF21; Region: DUF21; pfam01595 326423002823 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 326423002824 Transporter associated domain; Region: CorC_HlyC; smart01091 326423002825 camphor resistance protein CrcB; Provisional; Region: PRK14213 326423002826 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 326423002827 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 326423002828 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 326423002829 active site 326423002830 catalytic site [active] 326423002831 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 326423002832 Mechanosensitive ion channel; Region: MS_channel; pfam00924 326423002833 NAD-dependent deacetylase; Provisional; Region: PRK00481 326423002834 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 326423002835 NAD+ binding site [chemical binding]; other site 326423002836 substrate binding site [chemical binding]; other site 326423002837 Zn binding site [ion binding]; other site 326423002838 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 326423002839 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 326423002840 NodB motif; other site 326423002841 active site 326423002842 catalytic site [active] 326423002843 Zn binding site [ion binding]; other site 326423002844 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 326423002845 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 326423002846 homodimer interface [polypeptide binding]; other site 326423002847 substrate-cofactor binding pocket; other site 326423002848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423002849 catalytic residue [active] 326423002850 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423002851 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 326423002852 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326423002853 Ligand Binding Site [chemical binding]; other site 326423002854 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326423002855 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326423002856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326423002857 Walker A/P-loop; other site 326423002858 ATP binding site [chemical binding]; other site 326423002859 Q-loop/lid; other site 326423002860 ABC transporter signature motif; other site 326423002861 Walker B; other site 326423002862 D-loop; other site 326423002863 H-loop/switch region; other site 326423002864 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326423002865 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326423002866 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 326423002867 Walker A/P-loop; other site 326423002868 ATP binding site [chemical binding]; other site 326423002869 Q-loop/lid; other site 326423002870 ABC transporter signature motif; other site 326423002871 Walker B; other site 326423002872 D-loop; other site 326423002873 H-loop/switch region; other site 326423002874 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 326423002875 NADH(P)-binding; Region: NAD_binding_10; pfam13460 326423002876 NAD binding site [chemical binding]; other site 326423002877 substrate binding site [chemical binding]; other site 326423002878 putative active site [active] 326423002879 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 326423002880 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 326423002881 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 326423002882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 326423002883 hypothetical protein; Provisional; Region: PRK13676 326423002884 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 326423002885 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 326423002886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423002887 active site 326423002888 motif I; other site 326423002889 motif II; other site 326423002890 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 326423002891 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 326423002892 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326423002893 FeS/SAM binding site; other site 326423002894 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 326423002895 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 326423002896 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 326423002897 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 326423002898 TrkA-C domain; Region: TrkA_C; pfam02080 326423002899 enoyl-CoA hydratase; Provisional; Region: PRK07659 326423002900 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326423002901 substrate binding site [chemical binding]; other site 326423002902 oxyanion hole (OAH) forming residues; other site 326423002903 trimer interface [polypeptide binding]; other site 326423002904 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 326423002905 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 326423002906 Walker A/P-loop; other site 326423002907 ATP binding site [chemical binding]; other site 326423002908 Q-loop/lid; other site 326423002909 ABC transporter signature motif; other site 326423002910 Walker B; other site 326423002911 D-loop; other site 326423002912 H-loop/switch region; other site 326423002913 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 326423002914 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 326423002915 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 326423002916 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 326423002917 active site 326423002918 metal binding site [ion binding]; metal-binding site 326423002919 DNA binding site [nucleotide binding] 326423002920 Uncharacterized conserved protein [Function unknown]; Region: COG4717 326423002921 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 326423002922 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 326423002923 generic binding surface II; other site 326423002924 generic binding surface I; other site 326423002925 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326423002926 Zn2+ binding site [ion binding]; other site 326423002927 Mg2+ binding site [ion binding]; other site 326423002928 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 326423002929 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 326423002930 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 326423002931 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 326423002932 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 326423002933 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 326423002934 transcriptional regulator Hpr; Provisional; Region: PRK13777 326423002935 MarR family; Region: MarR; pfam01047 326423002936 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 326423002937 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 326423002938 homodimer interface [polypeptide binding]; other site 326423002939 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 326423002940 substrate-cofactor binding pocket; other site 326423002941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423002942 catalytic residue [active] 326423002943 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 326423002944 HIT family signature motif; other site 326423002945 catalytic residue [active] 326423002946 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 326423002947 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326423002948 Walker A/P-loop; other site 326423002949 ATP binding site [chemical binding]; other site 326423002950 Q-loop/lid; other site 326423002951 ABC transporter signature motif; other site 326423002952 Walker B; other site 326423002953 D-loop; other site 326423002954 H-loop/switch region; other site 326423002955 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 326423002956 EcsC protein family; Region: EcsC; pfam12787 326423002957 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 326423002958 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 326423002959 metal binding site [ion binding]; metal-binding site 326423002960 dimer interface [polypeptide binding]; other site 326423002961 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 326423002962 Transglycosylase; Region: Transgly; pfam00912 326423002963 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 326423002964 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326423002965 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 326423002966 substrate binding site [chemical binding]; other site 326423002967 active site 326423002968 ferrochelatase; Provisional; Region: PRK12435 326423002969 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 326423002970 C-terminal domain interface [polypeptide binding]; other site 326423002971 active site 326423002972 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 326423002973 active site 326423002974 N-terminal domain interface [polypeptide binding]; other site 326423002975 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 326423002976 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326423002977 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423002978 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423002979 Predicted membrane protein [Function unknown]; Region: COG1511 326423002980 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 326423002981 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 326423002982 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 326423002983 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 326423002984 dimer interface [polypeptide binding]; other site 326423002985 active site 326423002986 CoA binding pocket [chemical binding]; other site 326423002987 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 326423002988 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 326423002989 putative oligomer interface [polypeptide binding]; other site 326423002990 putative active site [active] 326423002991 metal binding site [ion binding]; metal-binding site 326423002992 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 326423002993 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 326423002994 YhfH-like protein; Region: YhfH; pfam14149 326423002995 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 326423002996 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 326423002997 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 326423002998 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 326423002999 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 326423003000 NADH(P)-binding; Region: NAD_binding_10; pfam13460 326423003001 NAD(P) binding site [chemical binding]; other site 326423003002 putative active site [active] 326423003003 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 326423003004 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 326423003005 acyl-activating enzyme (AAE) consensus motif; other site 326423003006 putative AMP binding site [chemical binding]; other site 326423003007 putative active site [active] 326423003008 putative CoA binding site [chemical binding]; other site 326423003009 Peptidase family M48; Region: Peptidase_M48; pfam01435 326423003010 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 326423003011 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 326423003012 active site 326423003013 catalytic residues [active] 326423003014 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 326423003015 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 326423003016 siderophore binding site; other site 326423003017 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326423003018 catalytic core [active] 326423003019 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 326423003020 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 326423003021 dimer interface [polypeptide binding]; other site 326423003022 active site 326423003023 acyl-CoA synthetase; Validated; Region: PRK07638 326423003024 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326423003025 acyl-activating enzyme (AAE) consensus motif; other site 326423003026 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 326423003027 acyl-activating enzyme (AAE) consensus motif; other site 326423003028 AMP binding site [chemical binding]; other site 326423003029 active site 326423003030 CoA binding site [chemical binding]; other site 326423003031 BioY family; Region: BioY; pfam02632 326423003032 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 326423003033 heme-binding site [chemical binding]; other site 326423003034 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 326423003035 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 326423003036 dimer interface [polypeptide binding]; other site 326423003037 putative CheW interface [polypeptide binding]; other site 326423003038 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 326423003039 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 326423003040 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 326423003041 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 326423003042 [2Fe-2S] cluster binding site [ion binding]; other site 326423003043 short chain dehydrogenase; Provisional; Region: PRK06701 326423003044 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 326423003045 NAD binding site [chemical binding]; other site 326423003046 metal binding site [ion binding]; metal-binding site 326423003047 active site 326423003048 A short protein domain of unknown function; Region: IDEAL; smart00914 326423003049 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 326423003050 Uncharacterized conserved protein [Function unknown]; Region: COG5646 326423003051 Uncharacterized conserved protein [Function unknown]; Region: COG5646 326423003052 MepB protein; Region: MepB; pfam08877 326423003053 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 326423003054 putative binding site; other site 326423003055 putative dimer interface [polypeptide binding]; other site 326423003056 Excalibur calcium-binding domain; Region: Excalibur; cl05460 326423003057 Uncharacterized conserved protein [Function unknown]; Region: COG0393 326423003058 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 326423003059 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 326423003060 Na binding site [ion binding]; other site 326423003061 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 326423003062 Uncharacterized conserved protein [Function unknown]; Region: COG0398 326423003063 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 326423003064 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 326423003065 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 326423003066 Catalytic site [active] 326423003067 hypothetical protein; Provisional; Region: PRK08244 326423003068 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 326423003069 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423003070 MarR family; Region: MarR; pfam01047 326423003071 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 326423003072 Putative ammonia monooxygenase; Region: AmoA; pfam05145 326423003073 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 326423003074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423003075 putative substrate translocation pore; other site 326423003076 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423003077 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423003078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423003079 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 326423003080 Uncharacterized conserved protein [Function unknown]; Region: COG1633 326423003081 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 326423003082 dinuclear metal binding motif [ion binding]; other site 326423003083 Predicted membrane protein [Function unknown]; Region: COG2323 326423003084 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 326423003085 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 326423003086 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 326423003087 Part of AAA domain; Region: AAA_19; pfam13245 326423003088 Family description; Region: UvrD_C_2; pfam13538 326423003089 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 326423003090 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 326423003091 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 326423003092 active site 326423003093 metal binding site [ion binding]; metal-binding site 326423003094 DNA binding site [nucleotide binding] 326423003095 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 326423003096 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 326423003097 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 326423003098 Walker A/P-loop; other site 326423003099 ATP binding site [chemical binding]; other site 326423003100 Q-loop/lid; other site 326423003101 ABC transporter signature motif; other site 326423003102 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 326423003103 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 326423003104 ABC transporter signature motif; other site 326423003105 Walker B; other site 326423003106 D-loop; other site 326423003107 H-loop/switch region; other site 326423003108 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 326423003109 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 326423003110 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 326423003111 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 326423003112 Spore germination protein GerPC; Region: GerPC; pfam10737 326423003113 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 326423003114 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 326423003115 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 326423003116 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 326423003117 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 326423003118 hypothetical protein; Provisional; Region: PRK13673 326423003119 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 326423003120 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 326423003121 active site 326423003122 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 326423003123 dimer interface [polypeptide binding]; other site 326423003124 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 326423003125 Ligand Binding Site [chemical binding]; other site 326423003126 Molecular Tunnel; other site 326423003127 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 326423003128 substrate binding pocket [chemical binding]; other site 326423003129 substrate-Mg2+ binding site; other site 326423003130 aspartate-rich region 1; other site 326423003131 aspartate-rich region 2; other site 326423003132 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 326423003133 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 326423003134 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 326423003135 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 326423003136 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326423003137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326423003138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 326423003139 DinB superfamily; Region: DinB_2; pfam12867 326423003140 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 326423003141 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 326423003142 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 326423003143 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 326423003144 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 326423003145 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 326423003146 FAD binding site [chemical binding]; other site 326423003147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 326423003148 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 326423003149 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 326423003150 S1 domain; Region: S1_2; pfam13509 326423003151 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 326423003152 RNA binding site [nucleotide binding]; other site 326423003153 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 326423003154 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 326423003155 ligand binding site [chemical binding]; other site 326423003156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326423003157 dimerization interface [polypeptide binding]; other site 326423003158 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 326423003159 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 326423003160 dimer interface [polypeptide binding]; other site 326423003161 putative CheW interface [polypeptide binding]; other site 326423003162 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326423003163 Cytochrome P450; Region: p450; cl12078 326423003164 EDD domain protein, DegV family; Region: DegV; TIGR00762 326423003165 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 326423003166 Uncharacterized conserved protein [Function unknown]; Region: COG1284 326423003167 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423003168 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423003169 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 326423003170 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 326423003171 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 326423003172 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326423003173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423003174 motif II; other site 326423003175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423003176 esterase; Provisional; Region: PRK10566 326423003177 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 326423003178 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 326423003179 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 326423003180 active site 326423003181 metal binding site [ion binding]; metal-binding site 326423003182 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 326423003183 FAD binding domain; Region: FAD_binding_4; pfam01565 326423003184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423003185 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423003186 putative substrate translocation pore; other site 326423003187 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 326423003188 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 326423003189 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 326423003190 heterotetramer interface [polypeptide binding]; other site 326423003191 active site pocket [active] 326423003192 cleavage site 326423003193 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 326423003194 nucleotide binding site [chemical binding]; other site 326423003195 N-acetyl-L-glutamate binding site [chemical binding]; other site 326423003196 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 326423003197 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326423003198 inhibitor-cofactor binding pocket; inhibition site 326423003199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423003200 catalytic residue [active] 326423003201 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 326423003202 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 326423003203 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 326423003204 catalytic site [active] 326423003205 subunit interface [polypeptide binding]; other site 326423003206 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 326423003207 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326423003208 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 326423003209 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 326423003210 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326423003211 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326423003212 ornithine carbamoyltransferase; Provisional; Region: PRK00779 326423003213 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 326423003214 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 326423003215 YjzC-like protein; Region: YjzC; pfam14168 326423003216 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 326423003217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326423003218 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 326423003219 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 326423003220 putative ligand binding site [chemical binding]; other site 326423003221 ComZ; Region: ComZ; pfam10815 326423003222 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 326423003223 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 326423003224 dimer interface [polypeptide binding]; other site 326423003225 active site 326423003226 CoA binding pocket [chemical binding]; other site 326423003227 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 326423003228 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 326423003229 dimer interface [polypeptide binding]; other site 326423003230 active site 326423003231 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 326423003232 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 326423003233 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326423003234 Walker A/P-loop; other site 326423003235 ATP binding site [chemical binding]; other site 326423003236 Q-loop/lid; other site 326423003237 ABC transporter signature motif; other site 326423003238 Walker B; other site 326423003239 D-loop; other site 326423003240 H-loop/switch region; other site 326423003241 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 326423003242 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 326423003243 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326423003244 Walker A/P-loop; other site 326423003245 ATP binding site [chemical binding]; other site 326423003246 Q-loop/lid; other site 326423003247 ABC transporter signature motif; other site 326423003248 Walker B; other site 326423003249 D-loop; other site 326423003250 H-loop/switch region; other site 326423003251 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 326423003252 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 326423003253 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 326423003254 peptide binding site [polypeptide binding]; other site 326423003255 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326423003256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423003257 dimer interface [polypeptide binding]; other site 326423003258 conserved gate region; other site 326423003259 putative PBP binding loops; other site 326423003260 ABC-ATPase subunit interface; other site 326423003261 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326423003262 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 326423003263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423003264 dimer interface [polypeptide binding]; other site 326423003265 conserved gate region; other site 326423003266 putative PBP binding loops; other site 326423003267 ABC-ATPase subunit interface; other site 326423003268 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 326423003269 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 326423003270 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 326423003271 active site 326423003272 HIGH motif; other site 326423003273 dimer interface [polypeptide binding]; other site 326423003274 KMSKS motif; other site 326423003275 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 326423003276 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 326423003277 peptide binding site [polypeptide binding]; other site 326423003278 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 326423003279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423003280 dimer interface [polypeptide binding]; other site 326423003281 conserved gate region; other site 326423003282 putative PBP binding loops; other site 326423003283 ABC-ATPase subunit interface; other site 326423003284 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326423003285 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 326423003286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423003287 dimer interface [polypeptide binding]; other site 326423003288 conserved gate region; other site 326423003289 putative PBP binding loops; other site 326423003290 ABC-ATPase subunit interface; other site 326423003291 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 326423003292 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326423003293 Walker A/P-loop; other site 326423003294 ATP binding site [chemical binding]; other site 326423003295 Q-loop/lid; other site 326423003296 ABC transporter signature motif; other site 326423003297 Walker B; other site 326423003298 D-loop; other site 326423003299 H-loop/switch region; other site 326423003300 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326423003301 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 326423003302 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326423003303 Walker A/P-loop; other site 326423003304 ATP binding site [chemical binding]; other site 326423003305 Q-loop/lid; other site 326423003306 ABC transporter signature motif; other site 326423003307 Walker B; other site 326423003308 D-loop; other site 326423003309 H-loop/switch region; other site 326423003310 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 326423003311 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 326423003312 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 326423003313 Coenzyme A binding pocket [chemical binding]; other site 326423003314 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 326423003315 ArsC family; Region: ArsC; pfam03960 326423003316 putative catalytic residues [active] 326423003317 thiol/disulfide switch; other site 326423003318 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 326423003319 adaptor protein; Provisional; Region: PRK02315 326423003320 Competence protein CoiA-like family; Region: CoiA; cl11541 326423003321 oligoendopeptidase F; Region: pepF; TIGR00181 326423003322 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 326423003323 active site 326423003324 Zn binding site [ion binding]; other site 326423003325 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 326423003326 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 326423003327 catalytic residues [active] 326423003328 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 326423003329 apolar tunnel; other site 326423003330 heme binding site [chemical binding]; other site 326423003331 dimerization interface [polypeptide binding]; other site 326423003332 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 326423003333 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 326423003334 N-acetyl-D-glucosamine binding site [chemical binding]; other site 326423003335 catalytic residue [active] 326423003336 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 326423003337 putative active site [active] 326423003338 putative metal binding residues [ion binding]; other site 326423003339 signature motif; other site 326423003340 putative triphosphate binding site [ion binding]; other site 326423003341 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 326423003342 synthetase active site [active] 326423003343 metal binding site [ion binding]; metal-binding site 326423003344 NTP binding site [chemical binding]; other site 326423003345 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 326423003346 ATP-NAD kinase; Region: NAD_kinase; pfam01513 326423003347 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 326423003348 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 326423003349 active site 326423003350 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 326423003351 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 326423003352 active site 326423003353 metal binding site [ion binding]; metal-binding site 326423003354 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 326423003355 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 326423003356 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 326423003357 TrkA-N domain; Region: TrkA_N; pfam02254 326423003358 TrkA-C domain; Region: TrkA_C; pfam02080 326423003359 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 326423003360 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 326423003361 thiamine phosphate binding site [chemical binding]; other site 326423003362 active site 326423003363 pyrophosphate binding site [ion binding]; other site 326423003364 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 326423003365 hydroxyglutarate oxidase; Provisional; Region: PRK11728 326423003366 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 326423003367 thiS-thiF/thiG interaction site; other site 326423003368 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 326423003369 ThiS interaction site; other site 326423003370 putative active site [active] 326423003371 tetramer interface [polypeptide binding]; other site 326423003372 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 326423003373 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 326423003374 ATP binding site [chemical binding]; other site 326423003375 substrate interface [chemical binding]; other site 326423003376 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 326423003377 dimer interface [polypeptide binding]; other site 326423003378 substrate binding site [chemical binding]; other site 326423003379 ATP binding site [chemical binding]; other site 326423003380 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 326423003381 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 326423003382 NAD binding site [chemical binding]; other site 326423003383 homotetramer interface [polypeptide binding]; other site 326423003384 homodimer interface [polypeptide binding]; other site 326423003385 substrate binding site [chemical binding]; other site 326423003386 active site 326423003387 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 326423003388 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 326423003389 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 326423003390 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 326423003391 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 326423003392 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 326423003393 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 326423003394 Putative methyltransferase; Region: Methyltransf_16; pfam10294 326423003395 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 326423003396 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 326423003397 Part of AAA domain; Region: AAA_19; pfam13245 326423003398 Family description; Region: UvrD_C_2; pfam13538 326423003399 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326423003400 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 326423003401 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 326423003402 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 326423003403 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 326423003404 Walker A/P-loop; other site 326423003405 ATP binding site [chemical binding]; other site 326423003406 Q-loop/lid; other site 326423003407 ABC transporter signature motif; other site 326423003408 Walker B; other site 326423003409 D-loop; other site 326423003410 H-loop/switch region; other site 326423003411 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 326423003412 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 326423003413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326423003414 Coenzyme A binding pocket [chemical binding]; other site 326423003415 hypothetical protein; Provisional; Region: PRK13679 326423003416 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 326423003417 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 326423003418 Putative esterase; Region: Esterase; pfam00756 326423003419 cystathionine gamma-synthase; Reviewed; Region: PRK08247 326423003420 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 326423003421 homodimer interface [polypeptide binding]; other site 326423003422 substrate-cofactor binding pocket; other site 326423003423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423003424 catalytic residue [active] 326423003425 cystathionine beta-lyase; Provisional; Region: PRK08064 326423003426 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 326423003427 homodimer interface [polypeptide binding]; other site 326423003428 substrate-cofactor binding pocket; other site 326423003429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423003430 catalytic residue [active] 326423003431 LXG domain of WXG superfamily; Region: LXG; pfam04740 326423003432 LXG domain of WXG superfamily; Region: LXG; pfam04740 326423003433 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 326423003434 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 326423003435 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 326423003436 Uncharacterized conserved protein [Function unknown]; Region: COG1359 326423003437 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423003438 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423003439 putative substrate translocation pore; other site 326423003440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423003441 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326423003442 putative Zn2+ binding site [ion binding]; other site 326423003443 putative DNA binding site [nucleotide binding]; other site 326423003444 dimerization interface [polypeptide binding]; other site 326423003445 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 326423003446 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 326423003447 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 326423003448 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 326423003449 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 326423003450 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 326423003451 NAD binding site [chemical binding]; other site 326423003452 homodimer interface [polypeptide binding]; other site 326423003453 active site 326423003454 substrate binding site [chemical binding]; other site 326423003455 galactokinase; Provisional; Region: PRK05322 326423003456 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 326423003457 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 326423003458 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 326423003459 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 326423003460 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 326423003461 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 326423003462 active site 326423003463 P-loop; other site 326423003464 phosphorylation site [posttranslational modification] 326423003465 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 326423003466 methionine cluster; other site 326423003467 active site 326423003468 phosphorylation site [posttranslational modification] 326423003469 metal binding site [ion binding]; metal-binding site 326423003470 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 326423003471 beta-galactosidase; Region: BGL; TIGR03356 326423003472 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 326423003473 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 326423003474 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 326423003475 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 326423003476 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 326423003477 Kelch motif; Region: Kelch_6; pfam13964 326423003478 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 326423003479 Kelch motif; Region: Kelch_1; pfam01344 326423003480 Kelch motif; Region: Kelch_1; pfam01344 326423003481 MgtC family; Region: MgtC; pfam02308 326423003482 Putative motility protein; Region: YjfB_motility; pfam14070 326423003483 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 326423003484 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 326423003485 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 326423003486 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 326423003487 catalytic loop [active] 326423003488 iron binding site [ion binding]; other site 326423003489 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 326423003490 4Fe-4S binding domain; Region: Fer4; pfam00037 326423003491 4Fe-4S binding domain; Region: Fer4; pfam00037 326423003492 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 326423003493 [4Fe-4S] binding site [ion binding]; other site 326423003494 molybdopterin cofactor binding site; other site 326423003495 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 326423003496 molybdopterin cofactor binding site; other site 326423003497 Uncharacterized conserved protein [Function unknown]; Region: COG2427 326423003498 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326423003499 Cytochrome P450; Region: p450; cl12078 326423003500 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 326423003501 glycosyltransferase, MGT family; Region: MGT; TIGR01426 326423003502 active site 326423003503 TDP-binding site; other site 326423003504 acceptor substrate-binding pocket; other site 326423003505 homodimer interface [polypeptide binding]; other site 326423003506 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 326423003507 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 326423003508 active site 326423003509 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 326423003510 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 326423003511 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 326423003512 Walker A/P-loop; other site 326423003513 ATP binding site [chemical binding]; other site 326423003514 Q-loop/lid; other site 326423003515 ABC transporter signature motif; other site 326423003516 Walker B; other site 326423003517 D-loop; other site 326423003518 H-loop/switch region; other site 326423003519 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 326423003520 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 326423003521 Uncharacterized conserved protein [Function unknown]; Region: COG2427 326423003522 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 326423003523 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326423003524 Glucuronate isomerase; Region: UxaC; pfam02614 326423003525 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 326423003526 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 326423003527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423003528 putative substrate translocation pore; other site 326423003529 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326423003530 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326423003531 DNA binding site [nucleotide binding] 326423003532 domain linker motif; other site 326423003533 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326423003534 dimerization interface [polypeptide binding]; other site 326423003535 ligand binding site [chemical binding]; other site 326423003536 altronate oxidoreductase; Provisional; Region: PRK03643 326423003537 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 326423003538 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 326423003539 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 326423003540 galactarate dehydratase; Region: galactar-dH20; TIGR03248 326423003541 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 326423003542 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 326423003543 DinB family; Region: DinB; cl17821 326423003544 DinB superfamily; Region: DinB_2; pfam12867 326423003545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326423003546 binding surface 326423003547 TPR motif; other site 326423003548 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423003549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 326423003550 binding surface 326423003551 TPR motif; other site 326423003552 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 326423003553 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 326423003554 amidase catalytic site [active] 326423003555 Zn binding residues [ion binding]; other site 326423003556 substrate binding site [chemical binding]; other site 326423003557 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 326423003558 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423003559 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 326423003560 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326423003561 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 326423003562 pentamer interface [polypeptide binding]; other site 326423003563 dodecaamer interface [polypeptide binding]; other site 326423003564 Protein of unknown function (DUF867); Region: DUF867; pfam05908 326423003565 Domain of unknown function (DUF955); Region: DUF955; pfam06114 326423003566 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326423003567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326423003568 non-specific DNA binding site [nucleotide binding]; other site 326423003569 salt bridge; other site 326423003570 sequence-specific DNA binding site [nucleotide binding]; other site 326423003571 hypothetical protein; Provisional; Region: PRK06921 326423003572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423003573 Walker A motif; other site 326423003574 ATP binding site [chemical binding]; other site 326423003575 Walker B motif; other site 326423003576 positive control sigma-like factor; Validated; Region: PRK06930 326423003577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423003578 DNA binding residues [nucleotide binding] 326423003579 Phage terminase small subunit; Region: Phage_terminase; pfam10668 326423003580 XkdW protein; Region: XkdW; pfam09636 326423003581 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 326423003582 Haemolysin XhlA; Region: XhlA; pfam10779 326423003583 Phage lysis protein, holin; Region: Phage_holin; pfam04688 326423003584 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 326423003585 amidase catalytic site [active] 326423003586 Zn binding residues [ion binding]; other site 326423003587 substrate binding site [chemical binding]; other site 326423003588 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423003589 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 326423003590 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326423003591 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 326423003592 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 326423003593 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 326423003594 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 326423003595 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 326423003596 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 326423003597 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326423003598 Zn binding site [ion binding]; other site 326423003599 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 326423003600 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326423003601 Zn binding site [ion binding]; other site 326423003602 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 326423003603 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 326423003604 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 326423003605 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 326423003606 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 326423003607 Ligand binding site; other site 326423003608 Putative Catalytic site; other site 326423003609 DXD motif; other site 326423003610 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 326423003611 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 326423003612 protein binding site [polypeptide binding]; other site 326423003613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423003614 putative substrate translocation pore; other site 326423003615 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326423003616 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 326423003617 SxDxEG motif; other site 326423003618 active site 326423003619 metal binding site [ion binding]; metal-binding site 326423003620 homopentamer interface [polypeptide binding]; other site 326423003621 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326423003622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423003623 dimer interface [polypeptide binding]; other site 326423003624 conserved gate region; other site 326423003625 putative PBP binding loops; other site 326423003626 ABC-ATPase subunit interface; other site 326423003627 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326423003628 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 326423003629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423003630 dimer interface [polypeptide binding]; other site 326423003631 conserved gate region; other site 326423003632 putative PBP binding loops; other site 326423003633 ABC-ATPase subunit interface; other site 326423003634 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 326423003635 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326423003636 Walker A/P-loop; other site 326423003637 ATP binding site [chemical binding]; other site 326423003638 Q-loop/lid; other site 326423003639 ABC transporter signature motif; other site 326423003640 Walker B; other site 326423003641 D-loop; other site 326423003642 H-loop/switch region; other site 326423003643 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326423003644 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 326423003645 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 326423003646 peptide binding site [polypeptide binding]; other site 326423003647 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 326423003648 dimer interface [polypeptide binding]; other site 326423003649 catalytic triad [active] 326423003650 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 326423003651 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 326423003652 active site 326423003653 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326423003654 NlpC/P60 family; Region: NLPC_P60; pfam00877 326423003655 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 326423003656 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326423003657 Walker A/P-loop; other site 326423003658 ATP binding site [chemical binding]; other site 326423003659 Q-loop/lid; other site 326423003660 ABC transporter signature motif; other site 326423003661 Walker B; other site 326423003662 D-loop; other site 326423003663 H-loop/switch region; other site 326423003664 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326423003665 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 326423003666 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 326423003667 Amidinotransferase; Region: Amidinotransf; pfam02274 326423003668 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 326423003669 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326423003670 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326423003671 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 326423003672 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 326423003673 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 326423003674 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 326423003675 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 326423003676 putative active site [active] 326423003677 putative substrate binding site [chemical binding]; other site 326423003678 putative cosubstrate binding site; other site 326423003679 catalytic site [active] 326423003680 gamma-glutamyl kinase; Provisional; Region: PRK05429 326423003681 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 326423003682 nucleotide binding site [chemical binding]; other site 326423003683 homotetrameric interface [polypeptide binding]; other site 326423003684 putative phosphate binding site [ion binding]; other site 326423003685 putative allosteric binding site; other site 326423003686 PUA domain; Region: PUA; pfam01472 326423003687 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 326423003688 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 326423003689 putative catalytic cysteine [active] 326423003690 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 326423003691 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326423003692 MarR family; Region: MarR; pfam01047 326423003693 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 326423003694 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 326423003695 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 326423003696 putative metal binding site; other site 326423003697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326423003698 binding surface 326423003699 TPR motif; other site 326423003700 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 326423003701 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 326423003702 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 326423003703 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 326423003704 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 326423003705 ligand binding site [chemical binding]; other site 326423003706 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 326423003707 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 326423003708 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 326423003709 THF binding site; other site 326423003710 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 326423003711 substrate binding site [chemical binding]; other site 326423003712 THF binding site; other site 326423003713 zinc-binding site [ion binding]; other site 326423003714 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 326423003715 active site 326423003716 catalytic residues [active] 326423003717 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 326423003718 Cobalt transport protein; Region: CbiQ; pfam02361 326423003719 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 326423003720 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326423003721 Walker A/P-loop; other site 326423003722 ATP binding site [chemical binding]; other site 326423003723 Q-loop/lid; other site 326423003724 ABC transporter signature motif; other site 326423003725 Walker B; other site 326423003726 D-loop; other site 326423003727 H-loop/switch region; other site 326423003728 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326423003729 Walker A/P-loop; other site 326423003730 ATP binding site [chemical binding]; other site 326423003731 Q-loop/lid; other site 326423003732 ABC transporter signature motif; other site 326423003733 Walker B; other site 326423003734 D-loop; other site 326423003735 H-loop/switch region; other site 326423003736 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 326423003737 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 326423003738 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423003739 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423003740 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 326423003741 active site 326423003742 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 326423003743 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 326423003744 MgtE intracellular N domain; Region: MgtE_N; smart00924 326423003745 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 326423003746 Divalent cation transporter; Region: MgtE; pfam01769 326423003747 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 326423003748 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 326423003749 DNA binding residues [nucleotide binding] 326423003750 putative dimer interface [polypeptide binding]; other site 326423003751 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423003752 MarR family; Region: MarR; pfam01047 326423003753 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 326423003754 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 326423003755 active site 326423003756 DNA binding site [nucleotide binding] 326423003757 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 326423003758 nucleotide binding site [chemical binding]; other site 326423003759 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 326423003760 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 326423003761 putative DNA binding site [nucleotide binding]; other site 326423003762 putative homodimer interface [polypeptide binding]; other site 326423003763 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 326423003764 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 326423003765 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 326423003766 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 326423003767 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326423003768 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 326423003769 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 326423003770 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 326423003771 heat shock protein HtpX; Provisional; Region: PRK05457 326423003772 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 326423003773 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 326423003774 Predicted membrane protein [Function unknown]; Region: COG2323 326423003775 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 326423003776 Acyltransferase family; Region: Acyl_transf_3; pfam01757 326423003777 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326423003778 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 326423003779 putative active site [active] 326423003780 heme pocket [chemical binding]; other site 326423003781 PAS domain; Region: PAS; smart00091 326423003782 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 326423003783 PAS domain; Region: PAS; smart00091 326423003784 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 326423003785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423003786 dimer interface [polypeptide binding]; other site 326423003787 phosphorylation site [posttranslational modification] 326423003788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423003789 ATP binding site [chemical binding]; other site 326423003790 Mg2+ binding site [ion binding]; other site 326423003791 G-X-G motif; other site 326423003792 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 326423003793 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 326423003794 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 326423003795 DNA binding site [nucleotide binding] 326423003796 active site 326423003797 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 326423003798 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 326423003799 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 326423003800 Phosphotransferase enzyme family; Region: APH; pfam01636 326423003801 Predicted amidohydrolase [General function prediction only]; Region: COG0388 326423003802 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 326423003803 putative active site [active] 326423003804 catalytic triad [active] 326423003805 putative dimer interface [polypeptide binding]; other site 326423003806 transaminase; Reviewed; Region: PRK08068 326423003807 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326423003808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423003809 homodimer interface [polypeptide binding]; other site 326423003810 catalytic residue [active] 326423003811 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 326423003812 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 326423003813 dimer interface [polypeptide binding]; other site 326423003814 active site 326423003815 catalytic residue [active] 326423003816 metal binding site [ion binding]; metal-binding site 326423003817 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 326423003818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423003819 motif II; other site 326423003820 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 326423003821 intersubunit interface [polypeptide binding]; other site 326423003822 active site 326423003823 Zn2+ binding site [ion binding]; other site 326423003824 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 326423003825 Cupin domain; Region: Cupin_2; pfam07883 326423003826 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 326423003827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423003828 dimer interface [polypeptide binding]; other site 326423003829 phosphorylation site [posttranslational modification] 326423003830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423003831 ATP binding site [chemical binding]; other site 326423003832 Mg2+ binding site [ion binding]; other site 326423003833 G-X-G motif; other site 326423003834 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423003835 MarR family; Region: MarR; pfam01047 326423003836 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 326423003837 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 326423003838 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 326423003839 ligand binding site [chemical binding]; other site 326423003840 flagellar motor protein MotA; Validated; Region: PRK08124 326423003841 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 326423003842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423003843 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326423003844 Walker A motif; other site 326423003845 ATP binding site [chemical binding]; other site 326423003846 Walker B motif; other site 326423003847 arginine finger; other site 326423003848 UvrB/uvrC motif; Region: UVR; pfam02151 326423003849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423003850 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326423003851 Walker A motif; other site 326423003852 ATP binding site [chemical binding]; other site 326423003853 Walker B motif; other site 326423003854 arginine finger; other site 326423003855 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 326423003856 Uncharacterized membrane protein [Function unknown]; Region: COG3949 326423003857 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 326423003858 Ligand Binding Site [chemical binding]; other site 326423003859 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 326423003860 active site 326423003861 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 326423003862 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 326423003863 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 326423003864 Predicted transcriptional regulators [Transcription]; Region: COG1733 326423003865 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326423003866 short chain dehydrogenase; Provisional; Region: PRK06500 326423003867 classical (c) SDRs; Region: SDR_c; cd05233 326423003868 NAD(P) binding site [chemical binding]; other site 326423003869 active site 326423003870 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 326423003871 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 326423003872 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 326423003873 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 326423003874 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 326423003875 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 326423003876 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 326423003877 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 326423003878 catalytic residues [active] 326423003879 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 326423003880 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326423003881 Soluble P-type ATPase [General function prediction only]; Region: COG4087 326423003882 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 326423003883 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 326423003884 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 326423003885 active site 326423003886 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326423003887 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326423003888 DNA binding site [nucleotide binding] 326423003889 domain linker motif; other site 326423003890 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 326423003891 putative dimerization interface [polypeptide binding]; other site 326423003892 putative ligand binding site [chemical binding]; other site 326423003893 CAT RNA binding domain; Region: CAT_RBD; pfam03123 326423003894 transcriptional antiterminator BglG; Provisional; Region: PRK09772 326423003895 PRD domain; Region: PRD; pfam00874 326423003896 PRD domain; Region: PRD; pfam00874 326423003897 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 326423003898 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 326423003899 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 326423003900 active site turn [active] 326423003901 phosphorylation site [posttranslational modification] 326423003902 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 326423003903 HPr interaction site; other site 326423003904 glycerol kinase (GK) interaction site [polypeptide binding]; other site 326423003905 active site 326423003906 phosphorylation site [posttranslational modification] 326423003907 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 326423003908 dimerization domain swap beta strand [polypeptide binding]; other site 326423003909 regulatory protein interface [polypeptide binding]; other site 326423003910 active site 326423003911 regulatory phosphorylation site [posttranslational modification]; other site 326423003912 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 326423003913 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 326423003914 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 326423003915 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 326423003916 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 326423003917 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 326423003918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326423003919 FeS/SAM binding site; other site 326423003920 Cache domain; Region: Cache_1; pfam02743 326423003921 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326423003922 dimerization interface [polypeptide binding]; other site 326423003923 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 326423003924 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 326423003925 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 326423003926 dimer interface [polypeptide binding]; other site 326423003927 putative CheW interface [polypeptide binding]; other site 326423003928 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 326423003929 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 326423003930 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 326423003931 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 326423003932 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 326423003933 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 326423003934 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 326423003935 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 326423003936 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326423003937 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 326423003938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326423003939 putative active site [active] 326423003940 heme pocket [chemical binding]; other site 326423003941 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 326423003942 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326423003943 putative active site [active] 326423003944 heme pocket [chemical binding]; other site 326423003945 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326423003946 putative active site [active] 326423003947 heme pocket [chemical binding]; other site 326423003948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423003949 dimer interface [polypeptide binding]; other site 326423003950 phosphorylation site [posttranslational modification] 326423003951 aminotransferase A; Validated; Region: PRK07683 326423003952 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326423003953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423003954 homodimer interface [polypeptide binding]; other site 326423003955 catalytic residue [active] 326423003956 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 326423003957 putative CheA interaction surface; other site 326423003958 Response regulator receiver domain; Region: Response_reg; pfam00072 326423003959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423003960 active site 326423003961 phosphorylation site [posttranslational modification] 326423003962 intermolecular recognition site; other site 326423003963 dimerization interface [polypeptide binding]; other site 326423003964 YkyB-like protein; Region: YkyB; pfam14177 326423003965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423003966 H+ Antiporter protein; Region: 2A0121; TIGR00900 326423003967 putative substrate translocation pore; other site 326423003968 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423003969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 326423003970 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 326423003971 phosphodiesterase YaeI; Provisional; Region: PRK11340 326423003972 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 326423003973 putative active site [active] 326423003974 putative metal binding site [ion binding]; other site 326423003975 short chain dehydrogenase; Provisional; Region: PRK07677 326423003976 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 326423003977 NAD(P) binding site [chemical binding]; other site 326423003978 substrate binding site [chemical binding]; other site 326423003979 homotetramer interface [polypeptide binding]; other site 326423003980 active site 326423003981 homodimer interface [polypeptide binding]; other site 326423003982 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326423003983 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 326423003984 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 326423003985 Protein of unknown function (DUF458); Region: DUF458; pfam04308 326423003986 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 326423003987 FOG: CBS domain [General function prediction only]; Region: COG0517 326423003988 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 326423003989 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423003990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423003991 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326423003992 dimerization interface [polypeptide binding]; other site 326423003993 flavodoxin; Provisional; Region: PRK06703 326423003994 BNR repeat-like domain; Region: BNR_2; pfam13088 326423003995 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 326423003996 flavodoxin, short chain; Region: flav_short; TIGR01753 326423003997 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 326423003998 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 326423003999 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 326423004000 active site 326423004001 trimer interface [polypeptide binding]; other site 326423004002 substrate binding site [chemical binding]; other site 326423004003 CoA binding site [chemical binding]; other site 326423004004 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 326423004005 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 326423004006 metal binding site [ion binding]; metal-binding site 326423004007 hypothetical protein; Provisional; Region: PRK03094 326423004008 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 326423004009 Mechanosensitive ion channel; Region: MS_channel; pfam00924 326423004010 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 326423004011 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 326423004012 catalytic residues [active] 326423004013 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 326423004014 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 326423004015 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 326423004016 GTP binding site; other site 326423004017 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 326423004018 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 326423004019 ATP binding site [chemical binding]; other site 326423004020 substrate interface [chemical binding]; other site 326423004021 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 326423004022 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 326423004023 dimer interface [polypeptide binding]; other site 326423004024 putative functional site; other site 326423004025 putative MPT binding site; other site 326423004026 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 326423004027 Walker A motif; other site 326423004028 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 326423004029 MoaE homodimer interface [polypeptide binding]; other site 326423004030 MoaD interaction [polypeptide binding]; other site 326423004031 active site residues [active] 326423004032 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 326423004033 MoaE interaction surface [polypeptide binding]; other site 326423004034 MoeB interaction surface [polypeptide binding]; other site 326423004035 thiocarboxylated glycine; other site 326423004036 Yip1 domain; Region: Yip1; pfam04893 326423004037 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 326423004038 HlyD family secretion protein; Region: HlyD_3; pfam13437 326423004039 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326423004040 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326423004041 Walker A/P-loop; other site 326423004042 ATP binding site [chemical binding]; other site 326423004043 Q-loop/lid; other site 326423004044 ABC transporter signature motif; other site 326423004045 Walker B; other site 326423004046 D-loop; other site 326423004047 H-loop/switch region; other site 326423004048 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326423004049 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 326423004050 FtsX-like permease family; Region: FtsX; pfam02687 326423004051 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 326423004052 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 326423004053 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 326423004054 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 326423004055 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 326423004056 putative substrate binding site [chemical binding]; other site 326423004057 putative ATP binding site [chemical binding]; other site 326423004058 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 326423004059 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 326423004060 active site 326423004061 phosphorylation site [posttranslational modification] 326423004062 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 326423004063 active site 326423004064 P-loop; other site 326423004065 phosphorylation site [posttranslational modification] 326423004066 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 326423004067 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 326423004068 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 326423004069 Catalytic site [active] 326423004070 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 326423004071 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326423004072 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326423004073 ABC transporter; Region: ABC_tran_2; pfam12848 326423004074 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326423004075 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 326423004076 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 326423004077 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 326423004078 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 326423004079 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 326423004080 rod-share determining protein MreBH; Provisional; Region: PRK13929 326423004081 MreB and similar proteins; Region: MreB_like; cd10225 326423004082 nucleotide binding site [chemical binding]; other site 326423004083 Mg binding site [ion binding]; other site 326423004084 putative protofilament interaction site [polypeptide binding]; other site 326423004085 RodZ interaction site [polypeptide binding]; other site 326423004086 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 326423004087 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 326423004088 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 326423004089 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 326423004090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326423004091 putative active site [active] 326423004092 heme pocket [chemical binding]; other site 326423004093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423004094 dimer interface [polypeptide binding]; other site 326423004095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423004096 ATP binding site [chemical binding]; other site 326423004097 Mg2+ binding site [ion binding]; other site 326423004098 G-X-G motif; other site 326423004099 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 326423004100 putative active site pocket [active] 326423004101 dimerization interface [polypeptide binding]; other site 326423004102 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 326423004103 putative active site pocket [active] 326423004104 dimerization interface [polypeptide binding]; other site 326423004105 putative catalytic residue [active] 326423004106 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 326423004107 TrkA-N domain; Region: TrkA_N; pfam02254 326423004108 TrkA-C domain; Region: TrkA_C; pfam02080 326423004109 adenine deaminase; Region: ade; TIGR01178 326423004110 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326423004111 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 326423004112 active site 326423004113 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 326423004114 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 326423004115 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 326423004116 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 326423004117 hypothetical protein; Provisional; Region: PRK13667 326423004118 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423004119 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326423004120 active site 326423004121 motif I; other site 326423004122 motif II; other site 326423004123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423004124 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 326423004125 active site 326423004126 catalytic residues [active] 326423004127 metal binding site [ion binding]; metal-binding site 326423004128 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 326423004129 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 326423004130 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326423004131 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 326423004132 FMN binding site [chemical binding]; other site 326423004133 substrate binding site [chemical binding]; other site 326423004134 putative catalytic residue [active] 326423004135 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423004136 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423004137 active site 326423004138 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423004139 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423004140 putative NADP binding site [chemical binding]; other site 326423004141 active site 326423004142 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423004143 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423004144 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423004145 active site 326423004146 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423004147 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423004148 putative NADP binding site [chemical binding]; other site 326423004149 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423004150 active site 326423004151 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423004152 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423004153 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 326423004154 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423004155 active site 326423004156 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423004157 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423004158 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423004159 putative NADP binding site [chemical binding]; other site 326423004160 active site 326423004161 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423004162 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423004163 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423004164 active site 326423004165 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423004166 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423004167 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423004168 putative NADP binding site [chemical binding]; other site 326423004169 active site 326423004170 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423004171 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423004172 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423004173 active site 326423004174 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423004175 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423004176 putative NADP binding site [chemical binding]; other site 326423004177 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423004178 active site 326423004179 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423004180 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423004181 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 326423004182 active site 326423004183 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423004184 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423004185 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423004186 putative NADP binding site [chemical binding]; other site 326423004187 active site 326423004188 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423004189 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423004190 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423004191 active site 326423004192 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423004193 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423004194 putative NADP binding site [chemical binding]; other site 326423004195 active site 326423004196 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423004197 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423004198 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423004199 active site 326423004200 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423004201 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423004202 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423004203 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423004204 putative NADP binding site [chemical binding]; other site 326423004205 active site 326423004206 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423004207 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423004208 active site 326423004209 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423004210 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423004211 putative NADP binding site [chemical binding]; other site 326423004212 KR domain; Region: KR; pfam08659 326423004213 active site 326423004214 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423004215 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423004216 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423004217 active site 326423004218 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423004219 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423004220 putative NADP binding site [chemical binding]; other site 326423004221 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423004222 active site 326423004223 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423004224 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423004225 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423004226 active site 326423004227 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423004228 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423004229 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423004230 putative NADP binding site [chemical binding]; other site 326423004231 KR domain; Region: KR; pfam08659 326423004232 active site 326423004233 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326423004234 Beta-lactamase; Region: Beta-lactamase; pfam00144 326423004235 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 326423004236 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 326423004237 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 326423004238 TPP-binding site [chemical binding]; other site 326423004239 tetramer interface [polypeptide binding]; other site 326423004240 heterodimer interface [polypeptide binding]; other site 326423004241 phosphorylation loop region [posttranslational modification] 326423004242 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 326423004243 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 326423004244 alpha subunit interface [polypeptide binding]; other site 326423004245 TPP binding site [chemical binding]; other site 326423004246 heterodimer interface [polypeptide binding]; other site 326423004247 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 326423004248 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 326423004249 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 326423004250 E3 interaction surface; other site 326423004251 lipoyl attachment site [posttranslational modification]; other site 326423004252 e3 binding domain; Region: E3_binding; pfam02817 326423004253 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 326423004254 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 326423004255 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326423004256 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326423004257 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 326423004258 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 326423004259 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 326423004260 NodB motif; other site 326423004261 active site 326423004262 catalytic site [active] 326423004263 metal binding site [ion binding]; metal-binding site 326423004264 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 326423004265 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 326423004266 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 326423004267 homodimer interface [polypeptide binding]; other site 326423004268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423004269 catalytic residue [active] 326423004270 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 326423004271 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 326423004272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 326423004273 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 326423004274 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 326423004275 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 326423004276 active site 326423004277 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 326423004278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423004279 Coenzyme A binding pocket [chemical binding]; other site 326423004280 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 326423004281 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 326423004282 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 326423004283 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 326423004284 active site 326423004285 Zn binding site [ion binding]; other site 326423004286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326423004287 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 326423004288 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423004289 DNA binding residues [nucleotide binding] 326423004290 Putative zinc-finger; Region: zf-HC2; pfam13490 326423004291 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 326423004292 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 326423004293 G1 box; other site 326423004294 putative GEF interaction site [polypeptide binding]; other site 326423004295 GTP/Mg2+ binding site [chemical binding]; other site 326423004296 Switch I region; other site 326423004297 G2 box; other site 326423004298 G3 box; other site 326423004299 Switch II region; other site 326423004300 G4 box; other site 326423004301 G5 box; other site 326423004302 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 326423004303 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 326423004304 YlaH-like protein; Region: YlaH; pfam14036 326423004305 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 326423004306 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 326423004307 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 326423004308 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 326423004309 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 326423004310 putative active site [active] 326423004311 PhoH-like protein; Region: PhoH; pfam02562 326423004312 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 326423004313 glutaminase A; Region: Gln_ase; TIGR03814 326423004314 hypothetical protein; Provisional; Region: PRK13666 326423004315 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 326423004316 pyruvate carboxylase; Reviewed; Region: PRK12999 326423004317 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326423004318 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 326423004319 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 326423004320 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 326423004321 active site 326423004322 catalytic residues [active] 326423004323 metal binding site [ion binding]; metal-binding site 326423004324 homodimer binding site [polypeptide binding]; other site 326423004325 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 326423004326 carboxyltransferase (CT) interaction site; other site 326423004327 biotinylation site [posttranslational modification]; other site 326423004328 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 326423004329 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 326423004330 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 326423004331 UbiA prenyltransferase family; Region: UbiA; pfam01040 326423004332 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 326423004333 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 326423004334 Cytochrome c; Region: Cytochrom_C; pfam00034 326423004335 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 326423004336 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 326423004337 D-pathway; other site 326423004338 Putative ubiquinol binding site [chemical binding]; other site 326423004339 Low-spin heme (heme b) binding site [chemical binding]; other site 326423004340 Putative water exit pathway; other site 326423004341 Binuclear center (heme o3/CuB) [ion binding]; other site 326423004342 K-pathway; other site 326423004343 Putative proton exit pathway; other site 326423004344 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 326423004345 Subunit I/III interface [polypeptide binding]; other site 326423004346 Subunit III/IV interface [polypeptide binding]; other site 326423004347 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 326423004348 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 326423004349 YugN-like family; Region: YugN; pfam08868 326423004350 FOG: CBS domain [General function prediction only]; Region: COG0517 326423004351 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 326423004352 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 326423004353 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 326423004354 Putative coat protein; Region: YlbD_coat; pfam14071 326423004355 YlbE-like protein; Region: YlbE; pfam14003 326423004356 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 326423004357 hypothetical protein; Provisional; Region: PRK02886 326423004358 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 326423004359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423004360 S-adenosylmethionine binding site [chemical binding]; other site 326423004361 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 326423004362 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 326423004363 active site 326423004364 (T/H)XGH motif; other site 326423004365 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 326423004366 Nucleoside recognition; Region: Gate; pfam07670 326423004367 Nucleoside recognition; Region: Gate; pfam07670 326423004368 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 326423004369 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 326423004370 active site 326423004371 nucleophile elbow; other site 326423004372 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 326423004373 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 326423004374 protein binding site [polypeptide binding]; other site 326423004375 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 326423004376 hypothetical protein; Provisional; Region: PRK13670 326423004377 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 326423004378 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 326423004379 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 326423004380 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 326423004381 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 326423004382 hypothetical protein; Provisional; Region: PRK13688 326423004383 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423004384 Coenzyme A binding pocket [chemical binding]; other site 326423004385 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 326423004386 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 326423004387 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 326423004388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 326423004389 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 326423004390 mraZ protein; Region: TIGR00242 326423004391 MraZ protein; Region: MraZ; pfam02381 326423004392 MraZ protein; Region: MraZ; pfam02381 326423004393 MraW methylase family; Region: Methyltransf_5; pfam01795 326423004394 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 326423004395 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 326423004396 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 326423004397 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 326423004398 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326423004399 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 326423004400 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 326423004401 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 326423004402 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 326423004403 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326423004404 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 326423004405 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 326423004406 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 326423004407 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326423004408 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326423004409 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 326423004410 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 326423004411 Mg++ binding site [ion binding]; other site 326423004412 putative catalytic motif [active] 326423004413 putative substrate binding site [chemical binding]; other site 326423004414 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 326423004415 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326423004416 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326423004417 stage V sporulation protein E; Region: spoVE; TIGR02615 326423004418 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 326423004419 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 326423004420 active site 326423004421 homodimer interface [polypeptide binding]; other site 326423004422 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 326423004423 FAD binding domain; Region: FAD_binding_4; pfam01565 326423004424 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 326423004425 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 326423004426 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 326423004427 Cell division protein FtsQ; Region: FtsQ; pfam03799 326423004428 cell division protein FtsA; Region: ftsA; TIGR01174 326423004429 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 326423004430 nucleotide binding site [chemical binding]; other site 326423004431 Cell division protein FtsA; Region: FtsA; pfam14450 326423004432 cell division protein FtsZ; Validated; Region: PRK09330 326423004433 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 326423004434 nucleotide binding site [chemical binding]; other site 326423004435 SulA interaction site; other site 326423004436 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 326423004437 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 326423004438 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 326423004439 active site 326423004440 catalytic triad [active] 326423004441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 326423004442 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 326423004443 Cna protein B-type domain; Region: Cna_B_2; pfam13715 326423004444 Cna protein B-type domain; Region: Cna_B_2; pfam13715 326423004445 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 326423004446 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 326423004447 sporulation sigma factor SigE; Reviewed; Region: PRK08301 326423004448 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326423004449 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423004450 DNA binding residues [nucleotide binding] 326423004451 sporulation sigma factor SigG; Reviewed; Region: PRK08215 326423004452 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326423004453 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 326423004454 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423004455 DNA binding residues [nucleotide binding] 326423004456 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 326423004457 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326423004458 Walker A/P-loop; other site 326423004459 ATP binding site [chemical binding]; other site 326423004460 Q-loop/lid; other site 326423004461 ABC transporter signature motif; other site 326423004462 Walker B; other site 326423004463 D-loop; other site 326423004464 H-loop/switch region; other site 326423004465 acetylornithine deacetylase; Validated; Region: PRK08596 326423004466 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 326423004467 metal binding site [ion binding]; metal-binding site 326423004468 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 326423004469 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 326423004470 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 326423004471 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 326423004472 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 326423004473 catalytic residue [active] 326423004474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 326423004475 YGGT family; Region: YGGT; pfam02325 326423004476 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 326423004477 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326423004478 RNA binding surface [nucleotide binding]; other site 326423004479 DivIVA protein; Region: DivIVA; pfam05103 326423004480 DivIVA domain; Region: DivI1A_domain; TIGR03544 326423004481 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 326423004482 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 326423004483 HIGH motif; other site 326423004484 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 326423004485 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 326423004486 active site 326423004487 KMSKS motif; other site 326423004488 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 326423004489 tRNA binding surface [nucleotide binding]; other site 326423004490 anticodon binding site; other site 326423004491 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 326423004492 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 326423004493 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 326423004494 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326423004495 RNA binding surface [nucleotide binding]; other site 326423004496 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 326423004497 active site 326423004498 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 326423004499 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326423004500 active site 326423004501 uracil-xanthine permease; Region: ncs2; TIGR00801 326423004502 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 326423004503 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 326423004504 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 326423004505 dihydroorotase; Validated; Region: pyrC; PRK09357 326423004506 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326423004507 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 326423004508 active site 326423004509 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 326423004510 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 326423004511 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 326423004512 catalytic site [active] 326423004513 subunit interface [polypeptide binding]; other site 326423004514 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 326423004515 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326423004516 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 326423004517 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 326423004518 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326423004519 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326423004520 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 326423004521 IMP binding site; other site 326423004522 dimer interface [polypeptide binding]; other site 326423004523 interdomain contacts; other site 326423004524 partial ornithine binding site; other site 326423004525 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 326423004526 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 326423004527 FAD binding pocket [chemical binding]; other site 326423004528 FAD binding motif [chemical binding]; other site 326423004529 phosphate binding motif [ion binding]; other site 326423004530 beta-alpha-beta structure motif; other site 326423004531 NAD binding pocket [chemical binding]; other site 326423004532 Iron coordination center [ion binding]; other site 326423004533 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 326423004534 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 326423004535 heterodimer interface [polypeptide binding]; other site 326423004536 active site 326423004537 FMN binding site [chemical binding]; other site 326423004538 homodimer interface [polypeptide binding]; other site 326423004539 substrate binding site [chemical binding]; other site 326423004540 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 326423004541 active site 326423004542 dimer interface [polypeptide binding]; other site 326423004543 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326423004544 active site 326423004545 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 326423004546 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 326423004547 Active Sites [active] 326423004548 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 326423004549 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 326423004550 ATP-sulfurylase; Region: ATPS; cd00517 326423004551 active site 326423004552 HXXH motif; other site 326423004553 flexible loop; other site 326423004554 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 326423004555 AAA domain; Region: AAA_18; pfam13238 326423004556 ligand-binding site [chemical binding]; other site 326423004557 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 326423004558 diphthine synthase; Region: dph5; TIGR00522 326423004559 active site 326423004560 SAM binding site [chemical binding]; other site 326423004561 homodimer interface [polypeptide binding]; other site 326423004562 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 326423004563 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 326423004564 putative active site [active] 326423004565 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 326423004566 putative active site [active] 326423004567 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 326423004568 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 326423004569 Domain of unknown function (DUF814); Region: DUF814; pfam05670 326423004570 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 326423004571 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 326423004572 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326423004573 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 326423004574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423004575 motif II; other site 326423004576 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 326423004577 hypothetical protein; Provisional; Region: PRK11820 326423004578 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 326423004579 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 326423004580 hypothetical protein; Provisional; Region: PRK04323 326423004581 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 326423004582 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 326423004583 catalytic site [active] 326423004584 G-X2-G-X-G-K; other site 326423004585 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 326423004586 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 326423004587 Flavoprotein; Region: Flavoprotein; pfam02441 326423004588 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 326423004589 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 326423004590 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326423004591 ATP binding site [chemical binding]; other site 326423004592 putative Mg++ binding site [ion binding]; other site 326423004593 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326423004594 nucleotide binding region [chemical binding]; other site 326423004595 ATP-binding site [chemical binding]; other site 326423004596 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 326423004597 active site 326423004598 catalytic residues [active] 326423004599 metal binding site [ion binding]; metal-binding site 326423004600 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 326423004601 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 326423004602 putative active site [active] 326423004603 substrate binding site [chemical binding]; other site 326423004604 putative cosubstrate binding site; other site 326423004605 catalytic site [active] 326423004606 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 326423004607 substrate binding site [chemical binding]; other site 326423004608 16S rRNA methyltransferase B; Provisional; Region: PRK14902 326423004609 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 326423004610 putative RNA binding site [nucleotide binding]; other site 326423004611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423004612 S-adenosylmethionine binding site [chemical binding]; other site 326423004613 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 326423004614 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326423004615 FeS/SAM binding site; other site 326423004616 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 326423004617 Protein phosphatase 2C; Region: PP2C; pfam00481 326423004618 active site 326423004619 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326423004620 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326423004621 active site 326423004622 ATP binding site [chemical binding]; other site 326423004623 substrate binding site [chemical binding]; other site 326423004624 activation loop (A-loop); other site 326423004625 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326423004626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 326423004627 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326423004628 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326423004629 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326423004630 GTPase RsgA; Reviewed; Region: PRK00098 326423004631 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 326423004632 RNA binding site [nucleotide binding]; other site 326423004633 homodimer interface [polypeptide binding]; other site 326423004634 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 326423004635 GTPase/Zn-binding domain interface [polypeptide binding]; other site 326423004636 GTP/Mg2+ binding site [chemical binding]; other site 326423004637 G4 box; other site 326423004638 G5 box; other site 326423004639 G1 box; other site 326423004640 Switch I region; other site 326423004641 G2 box; other site 326423004642 G3 box; other site 326423004643 Switch II region; other site 326423004644 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 326423004645 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 326423004646 substrate binding site [chemical binding]; other site 326423004647 hexamer interface [polypeptide binding]; other site 326423004648 metal binding site [ion binding]; metal-binding site 326423004649 Thiamine pyrophosphokinase; Region: TPK; cd07995 326423004650 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 326423004651 active site 326423004652 dimerization interface [polypeptide binding]; other site 326423004653 thiamine binding site [chemical binding]; other site 326423004654 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 326423004655 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 326423004656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 326423004657 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 326423004658 DAK2 domain; Region: Dak2; pfam02734 326423004659 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 326423004660 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 326423004661 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 326423004662 putative L-serine binding site [chemical binding]; other site 326423004663 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 326423004664 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 326423004665 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 326423004666 Y-family of DNA polymerases; Region: PolY; cl12025 326423004667 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 326423004668 generic binding surface II; other site 326423004669 ssDNA binding site; other site 326423004670 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326423004671 ATP binding site [chemical binding]; other site 326423004672 putative Mg++ binding site [ion binding]; other site 326423004673 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326423004674 nucleotide binding region [chemical binding]; other site 326423004675 ATP-binding site [chemical binding]; other site 326423004676 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 326423004677 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 326423004678 putative phosphate acyltransferase; Provisional; Region: PRK05331 326423004679 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 326423004680 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326423004681 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 326423004682 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 326423004683 NAD(P) binding site [chemical binding]; other site 326423004684 homotetramer interface [polypeptide binding]; other site 326423004685 homodimer interface [polypeptide binding]; other site 326423004686 active site 326423004687 acyl carrier protein; Provisional; Region: acpP; PRK00982 326423004688 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 326423004689 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 326423004690 dimerization interface [polypeptide binding]; other site 326423004691 active site 326423004692 metal binding site [ion binding]; metal-binding site 326423004693 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 326423004694 dsRNA binding site [nucleotide binding]; other site 326423004695 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 326423004696 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 326423004697 Walker A/P-loop; other site 326423004698 ATP binding site [chemical binding]; other site 326423004699 Q-loop/lid; other site 326423004700 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 326423004701 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 326423004702 ABC transporter signature motif; other site 326423004703 Walker B; other site 326423004704 D-loop; other site 326423004705 H-loop/switch region; other site 326423004706 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 326423004707 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 326423004708 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 326423004709 GTP binding site [chemical binding]; other site 326423004710 Phosphotransferase enzyme family; Region: APH; pfam01636 326423004711 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326423004712 active site 326423004713 ATP binding site [chemical binding]; other site 326423004714 putative DNA-binding protein; Validated; Region: PRK00118 326423004715 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 326423004716 signal recognition particle protein; Provisional; Region: PRK10867 326423004717 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 326423004718 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 326423004719 P loop; other site 326423004720 GTP binding site [chemical binding]; other site 326423004721 Signal peptide binding domain; Region: SRP_SPB; pfam02978 326423004722 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 326423004723 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 326423004724 KH domain; Region: KH_4; pfam13083 326423004725 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 326423004726 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 326423004727 RimM N-terminal domain; Region: RimM; pfam01782 326423004728 PRC-barrel domain; Region: PRC; pfam05239 326423004729 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 326423004730 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 326423004731 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 326423004732 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 326423004733 GTP/Mg2+ binding site [chemical binding]; other site 326423004734 G4 box; other site 326423004735 G5 box; other site 326423004736 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 326423004737 G1 box; other site 326423004738 G1 box; other site 326423004739 GTP/Mg2+ binding site [chemical binding]; other site 326423004740 Switch I region; other site 326423004741 G2 box; other site 326423004742 G2 box; other site 326423004743 G3 box; other site 326423004744 G3 box; other site 326423004745 Switch II region; other site 326423004746 Switch II region; other site 326423004747 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 326423004748 RNA/DNA hybrid binding site [nucleotide binding]; other site 326423004749 active site 326423004750 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 326423004751 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 326423004752 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 326423004753 CoA-ligase; Region: Ligase_CoA; pfam00549 326423004754 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 326423004755 CoA binding domain; Region: CoA_binding; smart00881 326423004756 CoA-ligase; Region: Ligase_CoA; pfam00549 326423004757 DNA protecting protein DprA; Region: dprA; TIGR00732 326423004758 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 326423004759 DNA topoisomerase I; Validated; Region: PRK05582 326423004760 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 326423004761 active site 326423004762 interdomain interaction site; other site 326423004763 putative metal-binding site [ion binding]; other site 326423004764 nucleotide binding site [chemical binding]; other site 326423004765 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 326423004766 domain I; other site 326423004767 DNA binding groove [nucleotide binding] 326423004768 phosphate binding site [ion binding]; other site 326423004769 domain II; other site 326423004770 domain III; other site 326423004771 nucleotide binding site [chemical binding]; other site 326423004772 catalytic site [active] 326423004773 domain IV; other site 326423004774 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 326423004775 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 326423004776 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 326423004777 Glucose inhibited division protein A; Region: GIDA; pfam01134 326423004778 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 326423004779 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 326423004780 active site 326423004781 Int/Topo IB signature motif; other site 326423004782 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 326423004783 active site 326423004784 HslU subunit interaction site [polypeptide binding]; other site 326423004785 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 326423004786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423004787 Walker A motif; other site 326423004788 ATP binding site [chemical binding]; other site 326423004789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 326423004790 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 326423004791 transcriptional repressor CodY; Validated; Region: PRK04158 326423004792 CodY GAF-like domain; Region: CodY; pfam06018 326423004793 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 326423004794 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 326423004795 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 326423004796 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 326423004797 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 326423004798 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 326423004799 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 326423004800 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 326423004801 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 326423004802 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 326423004803 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 326423004804 flagellar motor switch protein FliG; Region: fliG; TIGR00207 326423004805 MgtE intracellular N domain; Region: MgtE_N; smart00924 326423004806 FliG C-terminal domain; Region: FliG_C; pfam01706 326423004807 flagellar assembly protein H; Validated; Region: fliH; PRK06669 326423004808 Flagellar assembly protein FliH; Region: FliH; pfam02108 326423004809 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 326423004810 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 326423004811 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 326423004812 Walker A motif/ATP binding site; other site 326423004813 Walker B motif; other site 326423004814 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 326423004815 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 326423004816 Uncharacterized conserved protein [Function unknown]; Region: COG3334 326423004817 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 326423004818 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 326423004819 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 326423004820 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 326423004821 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 326423004822 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 326423004823 Flagellar protein (FlbD); Region: FlbD; pfam06289 326423004824 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 326423004825 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 326423004826 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 326423004827 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 326423004828 flagellar motor switch protein; Validated; Region: PRK08119 326423004829 CheC-like family; Region: CheC; pfam04509 326423004830 CheC-like family; Region: CheC; pfam04509 326423004831 flagellar motor switch protein FliN; Region: fliN; TIGR02480 326423004832 Response regulator receiver domain; Region: Response_reg; pfam00072 326423004833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423004834 active site 326423004835 phosphorylation site [posttranslational modification] 326423004836 intermolecular recognition site; other site 326423004837 dimerization interface [polypeptide binding]; other site 326423004838 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 326423004839 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 326423004840 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 326423004841 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 326423004842 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 326423004843 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 326423004844 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 326423004845 FHIPEP family; Region: FHIPEP; pfam00771 326423004846 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 326423004847 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326423004848 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 326423004849 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 326423004850 P-loop; other site 326423004851 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 326423004852 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 326423004853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423004854 active site 326423004855 phosphorylation site [posttranslational modification] 326423004856 intermolecular recognition site; other site 326423004857 dimerization interface [polypeptide binding]; other site 326423004858 CheB methylesterase; Region: CheB_methylest; pfam01339 326423004859 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 326423004860 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 326423004861 putative binding surface; other site 326423004862 active site 326423004863 P2 response regulator binding domain; Region: P2; pfam07194 326423004864 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 326423004865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423004866 ATP binding site [chemical binding]; other site 326423004867 Mg2+ binding site [ion binding]; other site 326423004868 G-X-G motif; other site 326423004869 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 326423004870 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 326423004871 putative CheA interaction surface; other site 326423004872 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 326423004873 CheC-like family; Region: CheC; pfam04509 326423004874 CheC-like family; Region: CheC; pfam04509 326423004875 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 326423004876 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 326423004877 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326423004878 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 326423004879 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423004880 DNA binding residues [nucleotide binding] 326423004881 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 326423004882 rRNA interaction site [nucleotide binding]; other site 326423004883 S8 interaction site; other site 326423004884 putative laminin-1 binding site; other site 326423004885 elongation factor Ts; Provisional; Region: tsf; PRK09377 326423004886 UBA/TS-N domain; Region: UBA; pfam00627 326423004887 Elongation factor TS; Region: EF_TS; pfam00889 326423004888 Elongation factor TS; Region: EF_TS; pfam00889 326423004889 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 326423004890 putative nucleotide binding site [chemical binding]; other site 326423004891 uridine monophosphate binding site [chemical binding]; other site 326423004892 homohexameric interface [polypeptide binding]; other site 326423004893 ribosome recycling factor; Reviewed; Region: frr; PRK00083 326423004894 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 326423004895 hinge region; other site 326423004896 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 326423004897 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 326423004898 catalytic residue [active] 326423004899 putative FPP diphosphate binding site; other site 326423004900 putative FPP binding hydrophobic cleft; other site 326423004901 dimer interface [polypeptide binding]; other site 326423004902 putative IPP diphosphate binding site; other site 326423004903 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 326423004904 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 326423004905 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 326423004906 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 326423004907 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 326423004908 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 326423004909 RIP metalloprotease RseP; Region: TIGR00054 326423004910 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 326423004911 active site 326423004912 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 326423004913 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 326423004914 protein binding site [polypeptide binding]; other site 326423004915 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 326423004916 putative substrate binding region [chemical binding]; other site 326423004917 prolyl-tRNA synthetase; Provisional; Region: PRK09194 326423004918 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 326423004919 dimer interface [polypeptide binding]; other site 326423004920 motif 1; other site 326423004921 active site 326423004922 motif 2; other site 326423004923 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 326423004924 putative deacylase active site [active] 326423004925 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 326423004926 active site 326423004927 motif 3; other site 326423004928 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 326423004929 anticodon binding site; other site 326423004930 DNA polymerase III PolC; Validated; Region: polC; PRK00448 326423004931 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 326423004932 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 326423004933 generic binding surface II; other site 326423004934 generic binding surface I; other site 326423004935 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 326423004936 active site 326423004937 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 326423004938 active site 326423004939 catalytic site [active] 326423004940 substrate binding site [chemical binding]; other site 326423004941 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 326423004942 ribosome maturation protein RimP; Reviewed; Region: PRK00092 326423004943 Sm and related proteins; Region: Sm_like; cl00259 326423004944 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 326423004945 putative oligomer interface [polypeptide binding]; other site 326423004946 putative RNA binding site [nucleotide binding]; other site 326423004947 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 326423004948 NusA N-terminal domain; Region: NusA_N; pfam08529 326423004949 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 326423004950 RNA binding site [nucleotide binding]; other site 326423004951 homodimer interface [polypeptide binding]; other site 326423004952 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 326423004953 G-X-X-G motif; other site 326423004954 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 326423004955 G-X-X-G motif; other site 326423004956 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 326423004957 putative RNA binding cleft [nucleotide binding]; other site 326423004958 hypothetical protein; Provisional; Region: PRK07714 326423004959 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 326423004960 translation initiation factor IF-2; Region: IF-2; TIGR00487 326423004961 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 326423004962 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 326423004963 G1 box; other site 326423004964 putative GEF interaction site [polypeptide binding]; other site 326423004965 GTP/Mg2+ binding site [chemical binding]; other site 326423004966 Switch I region; other site 326423004967 G2 box; other site 326423004968 G3 box; other site 326423004969 Switch II region; other site 326423004970 G4 box; other site 326423004971 G5 box; other site 326423004972 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 326423004973 Translation-initiation factor 2; Region: IF-2; pfam11987 326423004974 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 326423004975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 326423004976 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 326423004977 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 326423004978 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 326423004979 RNA binding site [nucleotide binding]; other site 326423004980 active site 326423004981 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 326423004982 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 326423004983 active site 326423004984 Riboflavin kinase; Region: Flavokinase; smart00904 326423004985 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 326423004986 16S/18S rRNA binding site [nucleotide binding]; other site 326423004987 S13e-L30e interaction site [polypeptide binding]; other site 326423004988 25S rRNA binding site [nucleotide binding]; other site 326423004989 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 326423004990 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 326423004991 RNase E interface [polypeptide binding]; other site 326423004992 trimer interface [polypeptide binding]; other site 326423004993 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 326423004994 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 326423004995 RNase E interface [polypeptide binding]; other site 326423004996 trimer interface [polypeptide binding]; other site 326423004997 active site 326423004998 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 326423004999 putative nucleic acid binding region [nucleotide binding]; other site 326423005000 G-X-X-G motif; other site 326423005001 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 326423005002 RNA binding site [nucleotide binding]; other site 326423005003 domain interface; other site 326423005004 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 326423005005 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 326423005006 NodB motif; other site 326423005007 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 326423005008 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 326423005009 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 326423005010 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 326423005011 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 326423005012 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 326423005013 NAD binding site [chemical binding]; other site 326423005014 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 326423005015 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 326423005016 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 326423005017 aspartate kinase I; Reviewed; Region: PRK08210 326423005018 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 326423005019 putative catalytic residues [active] 326423005020 putative nucleotide binding site [chemical binding]; other site 326423005021 putative aspartate binding site [chemical binding]; other site 326423005022 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 326423005023 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 326423005024 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 326423005025 dihydrodipicolinate synthase; Region: dapA; TIGR00674 326423005026 dimer interface [polypeptide binding]; other site 326423005027 active site 326423005028 catalytic residue [active] 326423005029 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 326423005030 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326423005031 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 326423005032 Clp protease; Region: CLP_protease; pfam00574 326423005033 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 326423005034 active site 326423005035 YlzJ-like protein; Region: YlzJ; pfam14035 326423005036 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 326423005037 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 326423005038 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326423005039 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 326423005040 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 326423005041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423005042 DNA-binding site [nucleotide binding]; DNA binding site 326423005043 UTRA domain; Region: UTRA; pfam07702 326423005044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423005045 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423005046 putative substrate translocation pore; other site 326423005047 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423005048 MarR family; Region: MarR_2; pfam12802 326423005049 MMPL family; Region: MMPL; pfam03176 326423005050 Predicted membrane protein [Function unknown]; Region: COG1511 326423005051 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 326423005052 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 326423005053 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 326423005054 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 326423005055 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 326423005056 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 326423005057 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 326423005058 classical (c) SDRs; Region: SDR_c; cd05233 326423005059 NAD(P) binding site [chemical binding]; other site 326423005060 active site 326423005061 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 326423005062 ACT domain; Region: ACT; pfam01842 326423005063 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 326423005064 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 326423005065 Helix-turn-helix domain; Region: HTH_25; pfam13413 326423005066 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 326423005067 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 326423005068 competence damage-inducible protein A; Provisional; Region: PRK00549 326423005069 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 326423005070 putative MPT binding site; other site 326423005071 Competence-damaged protein; Region: CinA; pfam02464 326423005072 recombinase A; Provisional; Region: recA; PRK09354 326423005073 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 326423005074 hexamer interface [polypeptide binding]; other site 326423005075 Walker A motif; other site 326423005076 ATP binding site [chemical binding]; other site 326423005077 Walker B motif; other site 326423005078 Beta-lactamase; Region: Beta-lactamase; pfam00144 326423005079 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 326423005080 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 326423005081 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 326423005082 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326423005083 Zn2+ binding site [ion binding]; other site 326423005084 Mg2+ binding site [ion binding]; other site 326423005085 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 326423005086 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 326423005087 putative active site [active] 326423005088 metal binding site [ion binding]; metal-binding site 326423005089 homodimer binding site [polypeptide binding]; other site 326423005090 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 326423005091 Threonine dehydrogenase; Region: TDH; cd05281 326423005092 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 326423005093 structural Zn binding site [ion binding]; other site 326423005094 catalytic Zn binding site [ion binding]; other site 326423005095 tetramer interface [polypeptide binding]; other site 326423005096 NADP binding site [chemical binding]; other site 326423005097 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 326423005098 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 326423005099 substrate-cofactor binding pocket; other site 326423005100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423005101 catalytic residue [active] 326423005102 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 326423005103 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 326423005104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326423005105 FeS/SAM binding site; other site 326423005106 TRAM domain; Region: TRAM; pfam01938 326423005107 Predicted membrane protein [Function unknown]; Region: COG4550 326423005108 Outer spore coat protein E (CotE); Region: CotE; pfam10628 326423005109 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 326423005110 MutS domain I; Region: MutS_I; pfam01624 326423005111 MutS domain II; Region: MutS_II; pfam05188 326423005112 MutS domain III; Region: MutS_III; pfam05192 326423005113 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 326423005114 Walker A/P-loop; other site 326423005115 ATP binding site [chemical binding]; other site 326423005116 Q-loop/lid; other site 326423005117 ABC transporter signature motif; other site 326423005118 Walker B; other site 326423005119 D-loop; other site 326423005120 H-loop/switch region; other site 326423005121 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 326423005122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423005123 ATP binding site [chemical binding]; other site 326423005124 Mg2+ binding site [ion binding]; other site 326423005125 G-X-G motif; other site 326423005126 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 326423005127 ATP binding site [chemical binding]; other site 326423005128 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 326423005129 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 326423005130 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 326423005131 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326423005132 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326423005133 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 326423005134 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 326423005135 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326423005136 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 326423005137 FMN binding site [chemical binding]; other site 326423005138 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 326423005139 substrate binding site [chemical binding]; other site 326423005140 putative catalytic residue [active] 326423005141 acyl carrier protein; Validated; Region: PRK07117 326423005142 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 326423005143 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 326423005144 dimer interface [polypeptide binding]; other site 326423005145 active site 326423005146 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326423005147 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 326423005148 substrate binding site [chemical binding]; other site 326423005149 oxyanion hole (OAH) forming residues; other site 326423005150 trimer interface [polypeptide binding]; other site 326423005151 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 326423005152 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326423005153 substrate binding site [chemical binding]; other site 326423005154 oxyanion hole (OAH) forming residues; other site 326423005155 trimer interface [polypeptide binding]; other site 326423005156 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 326423005157 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 326423005158 acyl-activating enzyme (AAE) consensus motif; other site 326423005159 putative AMP binding site [chemical binding]; other site 326423005160 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005161 Condensation domain; Region: Condensation; pfam00668 326423005162 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005163 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423005164 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 326423005165 acyl-activating enzyme (AAE) consensus motif; other site 326423005166 AMP binding site [chemical binding]; other site 326423005167 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005168 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326423005169 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423005170 active site 326423005171 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423005172 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423005173 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423005174 putative NADP binding site [chemical binding]; other site 326423005175 active site 326423005176 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005177 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423005178 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326423005179 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423005180 active site 326423005181 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423005182 putative NADP binding site [chemical binding]; other site 326423005183 active site 326423005184 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005185 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423005186 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423005187 active site 326423005188 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423005189 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326423005190 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423005191 active site 326423005192 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423005193 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423005194 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423005195 putative NADP binding site [chemical binding]; other site 326423005196 active site 326423005197 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423005198 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423005199 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423005200 active site 326423005201 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423005202 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423005203 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423005204 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423005205 active site 326423005206 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423005207 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423005208 putative NADP binding site [chemical binding]; other site 326423005209 active site 326423005210 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005211 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423005212 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423005213 active site 326423005214 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423005215 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005216 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423005217 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326423005218 active site 326423005219 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423005220 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423005221 putative NADP binding site [chemical binding]; other site 326423005222 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423005223 active site 326423005224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423005225 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005226 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423005227 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423005228 active site 326423005229 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423005230 putative NADP binding site [chemical binding]; other site 326423005231 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423005232 active site 326423005233 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005234 Condensation domain; Region: Condensation; pfam00668 326423005235 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005236 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423005237 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005238 acyl-activating enzyme (AAE) consensus motif; other site 326423005239 AMP binding site [chemical binding]; other site 326423005240 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005241 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326423005242 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423005243 active site 326423005244 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423005245 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423005246 putative NADP binding site [chemical binding]; other site 326423005247 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423005248 active site 326423005249 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423005250 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326423005251 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423005252 active site 326423005253 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423005254 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423005255 putative NADP binding site [chemical binding]; other site 326423005256 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423005257 active site 326423005258 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423005259 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326423005260 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423005261 active site 326423005262 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423005263 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423005264 putative NADP binding site [chemical binding]; other site 326423005265 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423005266 active site 326423005267 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326423005268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423005269 S-adenosylmethionine binding site [chemical binding]; other site 326423005270 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423005271 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423005272 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423005273 active site 326423005274 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423005275 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 326423005276 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423005277 active site 326423005278 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005279 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 326423005280 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326423005281 Cytochrome P450; Region: p450; cl12078 326423005282 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 326423005283 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 326423005284 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 326423005285 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 326423005286 active site 326423005287 catalytic triad [active] 326423005288 Protein of unknown function (DUF867); Region: DUF867; pfam05908 326423005289 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 326423005290 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 326423005291 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 326423005292 YmaF family; Region: YmaF; pfam12788 326423005293 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 326423005294 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 326423005295 bacterial Hfq-like; Region: Hfq; cd01716 326423005296 hexamer interface [polypeptide binding]; other site 326423005297 Sm1 motif; other site 326423005298 RNA binding site [nucleotide binding]; other site 326423005299 Sm2 motif; other site 326423005300 YmzC-like protein; Region: YmzC; pfam14157 326423005301 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 326423005302 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 326423005303 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 326423005304 Class I ribonucleotide reductase; Region: RNR_I; cd01679 326423005305 active site 326423005306 dimer interface [polypeptide binding]; other site 326423005307 catalytic residues [active] 326423005308 effector binding site; other site 326423005309 R2 peptide binding site; other site 326423005310 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 326423005311 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 326423005312 dimer interface [polypeptide binding]; other site 326423005313 putative radical transfer pathway; other site 326423005314 diiron center [ion binding]; other site 326423005315 tyrosyl radical; other site 326423005316 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 326423005317 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 326423005318 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 326423005319 active site 326423005320 metal binding site [ion binding]; metal-binding site 326423005321 Sporulation related domain; Region: SPOR; pfam05036 326423005322 stage V sporulation protein K; Region: spore_V_K; TIGR02881 326423005323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423005324 Walker A motif; other site 326423005325 ATP binding site [chemical binding]; other site 326423005326 Walker B motif; other site 326423005327 arginine finger; other site 326423005328 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 326423005329 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 326423005330 HflX GTPase family; Region: HflX; cd01878 326423005331 G1 box; other site 326423005332 GTP/Mg2+ binding site [chemical binding]; other site 326423005333 Switch I region; other site 326423005334 G2 box; other site 326423005335 G3 box; other site 326423005336 Switch II region; other site 326423005337 G4 box; other site 326423005338 G5 box; other site 326423005339 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 326423005340 Aluminium resistance protein; Region: Alum_res; pfam06838 326423005341 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 326423005342 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326423005343 DNA binding residues [nucleotide binding] 326423005344 glutamine synthetase, type I; Region: GlnA; TIGR00653 326423005345 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 326423005346 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 326423005347 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 326423005348 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326423005349 Major royal jelly protein; Region: MRJP; pfam03022 326423005350 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 326423005351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423005352 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 326423005353 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 326423005354 inhibitor binding site; inhibition site 326423005355 active site 326423005356 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326423005357 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 326423005358 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326423005359 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 326423005360 nucleotide binding site [chemical binding]; other site 326423005361 xylose isomerase; Provisional; Region: PRK05474 326423005362 xylose isomerase; Region: xylose_isom_A; TIGR02630 326423005363 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 326423005364 N- and C-terminal domain interface [polypeptide binding]; other site 326423005365 D-xylulose kinase; Region: XylB; TIGR01312 326423005366 active site 326423005367 MgATP binding site [chemical binding]; other site 326423005368 catalytic site [active] 326423005369 metal binding site [ion binding]; metal-binding site 326423005370 xylulose binding site [chemical binding]; other site 326423005371 homodimer interface [polypeptide binding]; other site 326423005372 phosphoenolpyruvate synthase; Validated; Region: PRK06241 326423005373 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 326423005374 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 326423005375 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 326423005376 DinB family; Region: DinB; cl17821 326423005377 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 326423005378 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 326423005379 NAD binding site [chemical binding]; other site 326423005380 substrate binding site [chemical binding]; other site 326423005381 catalytic Zn binding site [ion binding]; other site 326423005382 tetramer interface [polypeptide binding]; other site 326423005383 structural Zn binding site [ion binding]; other site 326423005384 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326423005385 YoaP-like; Region: YoaP; pfam14268 326423005386 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326423005387 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326423005388 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 326423005389 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 326423005390 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 326423005391 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326423005392 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 326423005393 Chitin binding domain; Region: Chitin_bind_3; pfam03067 326423005394 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 326423005395 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 326423005396 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 326423005397 trimer interface [polypeptide binding]; other site 326423005398 active site 326423005399 Protein of unknown function (DUF867); Region: DUF867; pfam05908 326423005400 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 326423005401 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 326423005402 LexA repressor; Validated; Region: PRK00215 326423005403 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326423005404 putative DNA binding site [nucleotide binding]; other site 326423005405 putative Zn2+ binding site [ion binding]; other site 326423005406 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 326423005407 Catalytic site [active] 326423005408 cell division suppressor protein YneA; Provisional; Region: PRK14125 326423005409 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423005410 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 326423005411 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 326423005412 catalytic residues [active] 326423005413 catalytic nucleophile [active] 326423005414 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 326423005415 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 326423005416 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 326423005417 TPP-binding site [chemical binding]; other site 326423005418 dimer interface [polypeptide binding]; other site 326423005419 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 326423005420 PYR/PP interface [polypeptide binding]; other site 326423005421 dimer interface [polypeptide binding]; other site 326423005422 TPP binding site [chemical binding]; other site 326423005423 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 326423005424 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 326423005425 hypothetical protein; Provisional; Region: PRK01844 326423005426 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 326423005427 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 326423005428 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 326423005429 Response regulator receiver domain; Region: Response_reg; pfam00072 326423005430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423005431 active site 326423005432 phosphorylation site [posttranslational modification] 326423005433 intermolecular recognition site; other site 326423005434 dimerization interface [polypeptide binding]; other site 326423005435 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 326423005436 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 326423005437 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 326423005438 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 326423005439 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 326423005440 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 326423005441 aconitate hydratase; Validated; Region: PRK09277 326423005442 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 326423005443 substrate binding site [chemical binding]; other site 326423005444 ligand binding site [chemical binding]; other site 326423005445 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 326423005446 substrate binding site [chemical binding]; other site 326423005447 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 326423005448 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 326423005449 catalytic residues [active] 326423005450 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 326423005451 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 326423005452 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 326423005453 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 326423005454 active site 326423005455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 326423005456 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 326423005457 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 326423005458 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 326423005459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423005460 ATP binding site [chemical binding]; other site 326423005461 Mg2+ binding site [ion binding]; other site 326423005462 G-X-G motif; other site 326423005463 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 326423005464 anchoring element; other site 326423005465 dimer interface [polypeptide binding]; other site 326423005466 ATP binding site [chemical binding]; other site 326423005467 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 326423005468 active site 326423005469 putative metal-binding site [ion binding]; other site 326423005470 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 326423005471 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 326423005472 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 326423005473 CAP-like domain; other site 326423005474 active site 326423005475 primary dimer interface [polypeptide binding]; other site 326423005476 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326423005477 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326423005478 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326423005479 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326423005480 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 326423005481 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 326423005482 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326423005483 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 326423005484 substrate binding site [chemical binding]; other site 326423005485 ATP binding site [chemical binding]; other site 326423005486 putative oxidoreductase; Provisional; Region: PRK10083 326423005487 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 326423005488 putative NAD(P) binding site [chemical binding]; other site 326423005489 catalytic Zn binding site [ion binding]; other site 326423005490 structural Zn binding site [ion binding]; other site 326423005491 Entner-Doudoroff aldolase; Region: eda; TIGR01182 326423005492 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 326423005493 active site 326423005494 intersubunit interface [polypeptide binding]; other site 326423005495 catalytic residue [active] 326423005496 mannonate dehydratase; Provisional; Region: PRK03906 326423005497 D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786 326423005498 D-mannonate oxidoreductase; Provisional; Region: PRK08277 326423005499 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 326423005500 putative NAD(P) binding site [chemical binding]; other site 326423005501 active site 326423005502 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326423005503 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326423005504 DNA binding site [nucleotide binding] 326423005505 domain linker motif; other site 326423005506 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 326423005507 putative dimerization interface [polypeptide binding]; other site 326423005508 putative ligand binding site [chemical binding]; other site 326423005509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423005510 D-galactonate transporter; Region: 2A0114; TIGR00893 326423005511 putative substrate translocation pore; other site 326423005512 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 326423005513 YndJ-like protein; Region: YndJ; pfam14158 326423005514 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 326423005515 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 326423005516 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 326423005517 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 326423005518 Cellulose binding domain; Region: CBM_3; pfam00942 326423005519 Tic20-like protein; Region: Tic20; pfam09685 326423005520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423005521 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 326423005522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423005523 dimer interface [polypeptide binding]; other site 326423005524 phosphorylation site [posttranslational modification] 326423005525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423005526 ATP binding site [chemical binding]; other site 326423005527 Mg2+ binding site [ion binding]; other site 326423005528 G-X-G motif; other site 326423005529 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423005530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423005531 active site 326423005532 phosphorylation site [posttranslational modification] 326423005533 intermolecular recognition site; other site 326423005534 dimerization interface [polypeptide binding]; other site 326423005535 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423005536 DNA binding site [nucleotide binding] 326423005537 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 326423005538 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 326423005539 substrate binding site [chemical binding]; other site 326423005540 active site 326423005541 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 326423005542 metal binding site [ion binding]; metal-binding site 326423005543 ligand binding site [chemical binding]; other site 326423005544 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005545 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 326423005546 acyl-activating enzyme (AAE) consensus motif; other site 326423005547 AMP binding site [chemical binding]; other site 326423005548 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005549 Condensation domain; Region: Condensation; pfam00668 326423005550 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005551 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 326423005552 Condensation domain; Region: Condensation; pfam00668 326423005553 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 326423005554 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423005555 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005556 acyl-activating enzyme (AAE) consensus motif; other site 326423005557 AMP binding site [chemical binding]; other site 326423005558 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005559 Putative lysophospholipase; Region: Hydrolase_4; cl19140 326423005560 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005561 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423005562 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005563 acyl-activating enzyme (AAE) consensus motif; other site 326423005564 AMP binding site [chemical binding]; other site 326423005565 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005566 Condensation domain; Region: Condensation; pfam00668 326423005567 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005568 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 326423005569 Condensation domain; Region: Condensation; pfam00668 326423005570 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005571 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005572 acyl-activating enzyme (AAE) consensus motif; other site 326423005573 AMP binding site [chemical binding]; other site 326423005574 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005575 Condensation domain; Region: Condensation; pfam00668 326423005576 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 326423005577 Condensation domain; Region: Condensation; pfam00668 326423005578 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005579 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005580 acyl-activating enzyme (AAE) consensus motif; other site 326423005581 AMP binding site [chemical binding]; other site 326423005582 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005583 Condensation domain; Region: Condensation; pfam00668 326423005584 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005585 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423005586 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005587 acyl-activating enzyme (AAE) consensus motif; other site 326423005588 AMP binding site [chemical binding]; other site 326423005589 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005590 Condensation domain; Region: Condensation; pfam00668 326423005591 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005592 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423005593 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 326423005594 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 326423005595 acyl-activating enzyme (AAE) consensus motif; other site 326423005596 putative AMP binding site [chemical binding]; other site 326423005597 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005598 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423005599 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423005600 active site 326423005601 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005602 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 326423005603 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326423005604 inhibitor-cofactor binding pocket; inhibition site 326423005605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423005606 catalytic residue [active] 326423005607 Condensation domain; Region: Condensation; cl19241 326423005608 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423005609 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005610 Condensation domain; Region: Condensation; pfam00668 326423005611 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005612 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423005613 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005614 acyl-activating enzyme (AAE) consensus motif; other site 326423005615 AMP binding site [chemical binding]; other site 326423005616 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005617 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 326423005618 Condensation domain; Region: Condensation; pfam00668 326423005619 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423005620 Acyl transferase domain; Region: Acyl_transf_1; cl08282 326423005621 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 326423005622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326423005623 NAD(P) binding site [chemical binding]; other site 326423005624 active site 326423005625 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 326423005626 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 326423005627 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 326423005628 fructuronate transporter; Provisional; Region: PRK10034; cl15264 326423005629 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326423005630 biotin synthase; Validated; Region: PRK06256 326423005631 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326423005632 FeS/SAM binding site; other site 326423005633 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 326423005634 AAA domain; Region: AAA_26; pfam13500 326423005635 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 326423005636 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 326423005637 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 326423005638 substrate-cofactor binding pocket; other site 326423005639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423005640 catalytic residue [active] 326423005641 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 326423005642 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326423005643 inhibitor-cofactor binding pocket; inhibition site 326423005644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423005645 catalytic residue [active] 326423005646 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 326423005647 GtrA-like protein; Region: GtrA; pfam04138 326423005648 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 326423005649 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 326423005650 active site 326423005651 tetramer interface; other site 326423005652 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 326423005653 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 326423005654 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 326423005655 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 326423005656 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 326423005657 enoyl-CoA hydratase; Provisional; Region: PRK07657 326423005658 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326423005659 substrate binding site [chemical binding]; other site 326423005660 oxyanion hole (OAH) forming residues; other site 326423005661 trimer interface [polypeptide binding]; other site 326423005662 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 326423005663 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 326423005664 active site 326423005665 catalytic residues [active] 326423005666 metal binding site [ion binding]; metal-binding site 326423005667 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 326423005668 carboxyltransferase (CT) interaction site; other site 326423005669 biotinylation site [posttranslational modification]; other site 326423005670 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 326423005671 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326423005672 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 326423005673 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 326423005674 AMP-binding domain protein; Validated; Region: PRK08315 326423005675 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 326423005676 acyl-activating enzyme (AAE) consensus motif; other site 326423005677 putative AMP binding site [chemical binding]; other site 326423005678 putative active site [active] 326423005679 putative CoA binding site [chemical binding]; other site 326423005680 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326423005681 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326423005682 active site 326423005683 Glycosyl hydrolase like GH101; Region: DUF187; pfam02638 326423005684 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 326423005685 Condensation domain; Region: Condensation; pfam00668 326423005686 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005687 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 326423005688 acyl-activating enzyme (AAE) consensus motif; other site 326423005689 AMP binding site [chemical binding]; other site 326423005690 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005691 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 326423005692 Condensation domain; Region: Condensation; pfam00668 326423005693 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005694 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005695 acyl-activating enzyme (AAE) consensus motif; other site 326423005696 AMP binding site [chemical binding]; other site 326423005697 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005698 Condensation domain; Region: Condensation; pfam00668 326423005699 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005700 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423005701 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005702 acyl-activating enzyme (AAE) consensus motif; other site 326423005703 AMP binding site [chemical binding]; other site 326423005704 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005705 Condensation domain; Region: Condensation; pfam00668 326423005706 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005707 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423005708 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005709 acyl-activating enzyme (AAE) consensus motif; other site 326423005710 AMP binding site [chemical binding]; other site 326423005711 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005712 Condensation domain; Region: Condensation; pfam00668 326423005713 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 326423005714 Condensation domain; Region: Condensation; pfam00668 326423005715 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005716 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005717 acyl-activating enzyme (AAE) consensus motif; other site 326423005718 AMP binding site [chemical binding]; other site 326423005719 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005720 Condensation domain; Region: Condensation; pfam00668 326423005721 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005722 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423005723 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 326423005724 acyl-activating enzyme (AAE) consensus motif; other site 326423005725 AMP binding site [chemical binding]; other site 326423005726 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005727 Condensation domain; Region: Condensation; pfam00668 326423005728 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 326423005729 Condensation domain; Region: Condensation; pfam00668 326423005730 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005731 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005732 acyl-activating enzyme (AAE) consensus motif; other site 326423005733 AMP binding site [chemical binding]; other site 326423005734 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005735 Condensation domain; Region: Condensation; pfam00668 326423005736 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005737 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423005738 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 326423005739 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005740 acyl-activating enzyme (AAE) consensus motif; other site 326423005741 AMP binding site [chemical binding]; other site 326423005742 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005743 Condensation domain; Region: Condensation; pfam00668 326423005744 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 326423005745 Condensation domain; Region: Condensation; pfam00668 326423005746 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005747 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423005748 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005749 acyl-activating enzyme (AAE) consensus motif; other site 326423005750 AMP binding site [chemical binding]; other site 326423005751 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005752 Condensation domain; Region: Condensation; pfam00668 326423005753 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423005754 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423005755 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423005756 acyl-activating enzyme (AAE) consensus motif; other site 326423005757 AMP binding site [chemical binding]; other site 326423005758 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423005759 Condensation domain; Region: Condensation; pfam00668 326423005760 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 326423005761 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 326423005762 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 326423005763 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 326423005764 active site 326423005765 catalytic residues [active] 326423005766 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 326423005767 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 326423005768 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 326423005769 Int/Topo IB signature motif; other site 326423005770 Helix-turn-helix domain; Region: HTH_17; cl17695 326423005771 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 326423005772 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 326423005773 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 326423005774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423005775 putative substrate translocation pore; other site 326423005776 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326423005777 dimerization interface [polypeptide binding]; other site 326423005778 putative DNA binding site [nucleotide binding]; other site 326423005779 putative Zn2+ binding site [ion binding]; other site 326423005780 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 326423005781 anticodon binding site; other site 326423005782 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423005783 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423005784 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 326423005785 putative dimerization interface [polypeptide binding]; other site 326423005786 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 326423005787 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 326423005788 NAD(P) binding site [chemical binding]; other site 326423005789 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 326423005790 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326423005791 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 326423005792 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 326423005793 active site 326423005794 dimer interface [polypeptide binding]; other site 326423005795 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 326423005796 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 326423005797 active site 326423005798 FMN binding site [chemical binding]; other site 326423005799 substrate binding site [chemical binding]; other site 326423005800 3Fe-4S cluster binding site [ion binding]; other site 326423005801 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 326423005802 domain interface; other site 326423005803 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423005804 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423005805 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 326423005806 putative dimerization interface [polypeptide binding]; other site 326423005807 gamma-glutamyl kinase; Provisional; Region: PRK13402 326423005808 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 326423005809 nucleotide binding site [chemical binding]; other site 326423005810 homotetrameric interface [polypeptide binding]; other site 326423005811 putative phosphate binding site [ion binding]; other site 326423005812 putative allosteric binding site; other site 326423005813 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 326423005814 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 326423005815 Replication terminator protein; Region: RTP; pfam02334 326423005816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326423005817 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 326423005818 Coenzyme A binding pocket [chemical binding]; other site 326423005819 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 326423005820 classical (c) SDRs; Region: SDR_c; cd05233 326423005821 NAD(P) binding site [chemical binding]; other site 326423005822 active site 326423005823 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 326423005824 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326423005825 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 326423005826 classical (c) SDRs; Region: SDR_c; cd05233 326423005827 NAD(P) binding site [chemical binding]; other site 326423005828 active site 326423005829 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 326423005830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423005831 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423005832 putative substrate translocation pore; other site 326423005833 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 326423005834 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 326423005835 putative N- and C-terminal domain interface [polypeptide binding]; other site 326423005836 putative active site [active] 326423005837 putative MgATP binding site [chemical binding]; other site 326423005838 catalytic site [active] 326423005839 metal binding site [ion binding]; metal-binding site 326423005840 carbohydrate binding site [chemical binding]; other site 326423005841 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 326423005842 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 326423005843 putative ligand binding site [chemical binding]; other site 326423005844 putative NAD binding site [chemical binding]; other site 326423005845 catalytic site [active] 326423005846 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 326423005847 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 326423005848 putative [4Fe-4S] binding site [ion binding]; other site 326423005849 putative molybdopterin cofactor binding site [chemical binding]; other site 326423005850 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 326423005851 putative molybdopterin cofactor binding site; other site 326423005852 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423005853 MarR family; Region: MarR_2; pfam12802 326423005854 MarR family; Region: MarR_2; cl17246 326423005855 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 326423005856 Uncharacterized conserved protein [Function unknown]; Region: COG5444 326423005857 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 326423005858 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 326423005859 dimer interface [polypeptide binding]; other site 326423005860 putative tRNA-binding site [nucleotide binding]; other site 326423005861 Cupin domain; Region: Cupin_2; pfam07883 326423005862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326423005863 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 326423005864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326423005865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423005866 WHG domain; Region: WHG; pfam13305 326423005867 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326423005868 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326423005869 dimerization interface [polypeptide binding]; other site 326423005870 putative DNA binding site [nucleotide binding]; other site 326423005871 putative Zn2+ binding site [ion binding]; other site 326423005872 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 326423005873 N-acetyl-D-glucosamine binding site [chemical binding]; other site 326423005874 catalytic residue [active] 326423005875 Predicted membrane protein [Function unknown]; Region: COG2322 326423005876 Protein required for attachment to host cells; Region: Host_attach; cl02398 326423005877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326423005878 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 326423005879 putative dimer interface [polypeptide binding]; other site 326423005880 catalytic triad [active] 326423005881 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423005882 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423005883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 326423005884 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 326423005885 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326423005886 ATP binding site [chemical binding]; other site 326423005887 putative Mg++ binding site [ion binding]; other site 326423005888 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326423005889 nucleotide binding region [chemical binding]; other site 326423005890 ATP-binding site [chemical binding]; other site 326423005891 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 326423005892 HRDC domain; Region: HRDC; pfam00570 326423005893 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 326423005894 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 326423005895 putative dimer interface [polypeptide binding]; other site 326423005896 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 326423005897 pentamer interface [polypeptide binding]; other site 326423005898 dodecaamer interface [polypeptide binding]; other site 326423005899 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 326423005900 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 326423005901 NAD(P) binding site [chemical binding]; other site 326423005902 catalytic residues [active] 326423005903 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 326423005904 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 326423005905 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 326423005906 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 326423005907 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 326423005908 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 326423005909 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 326423005910 Na2 binding site [ion binding]; other site 326423005911 putative substrate binding site 1 [chemical binding]; other site 326423005912 Na binding site 1 [ion binding]; other site 326423005913 putative substrate binding site 2 [chemical binding]; other site 326423005914 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 326423005915 Sodium Bile acid symporter family; Region: SBF; pfam01758 326423005916 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326423005917 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 326423005918 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 326423005919 E3 interaction surface; other site 326423005920 lipoyl attachment site [posttranslational modification]; other site 326423005921 e3 binding domain; Region: E3_binding; pfam02817 326423005922 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 326423005923 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 326423005924 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 326423005925 TPP-binding site [chemical binding]; other site 326423005926 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 326423005927 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 326423005928 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 326423005929 metal ion-dependent adhesion site (MIDAS); other site 326423005930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423005931 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326423005932 Walker A motif; other site 326423005933 ATP binding site [chemical binding]; other site 326423005934 Walker B motif; other site 326423005935 arginine finger; other site 326423005936 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 326423005937 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 326423005938 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 326423005939 E-class dimer interface [polypeptide binding]; other site 326423005940 P-class dimer interface [polypeptide binding]; other site 326423005941 active site 326423005942 Cu2+ binding site [ion binding]; other site 326423005943 Zn2+ binding site [ion binding]; other site 326423005944 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423005945 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 326423005946 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423005947 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 326423005948 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423005949 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 326423005950 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423005951 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326423005952 NlpC/P60 family; Region: NLPC_P60; pfam00877 326423005953 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 326423005954 glycosyltransferase, MGT family; Region: MGT; TIGR01426 326423005955 active site 326423005956 TDP-binding site; other site 326423005957 acceptor substrate-binding pocket; other site 326423005958 homodimer interface [polypeptide binding]; other site 326423005959 Uncharacterized conserved protein [Function unknown]; Region: COG1624 326423005960 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 326423005961 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 326423005962 multidrug efflux protein; Reviewed; Region: PRK01766 326423005963 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 326423005964 cation binding site [ion binding]; other site 326423005965 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 326423005966 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 326423005967 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 326423005968 Predicted permeases [General function prediction only]; Region: RarD; COG2962 326423005969 EamA-like transporter family; Region: EamA; pfam00892 326423005970 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 326423005971 Predicted transcriptional regulators [Transcription]; Region: COG1733 326423005972 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326423005973 dimerization interface [polypeptide binding]; other site 326423005974 putative DNA binding site [nucleotide binding]; other site 326423005975 putative Zn2+ binding site [ion binding]; other site 326423005976 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 326423005977 dimer interface [polypeptide binding]; other site 326423005978 FMN binding site [chemical binding]; other site 326423005979 Predicted esterase [General function prediction only]; Region: COG0400 326423005980 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 326423005981 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326423005982 Zn binding site [ion binding]; other site 326423005983 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 326423005984 Zn binding site [ion binding]; other site 326423005985 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 326423005986 Na binding site [ion binding]; other site 326423005987 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 326423005988 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 326423005989 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 326423005990 beta-galactosidase; Region: BGL; TIGR03356 326423005991 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 326423005992 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423005993 DNA-binding site [nucleotide binding]; DNA binding site 326423005994 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 326423005995 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 326423005996 C-terminal peptidase (prc); Region: prc; TIGR00225 326423005997 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 326423005998 protein binding site [polypeptide binding]; other site 326423005999 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 326423006000 Catalytic dyad [active] 326423006001 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326423006002 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423006003 S-adenosylmethionine binding site [chemical binding]; other site 326423006004 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 326423006005 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 326423006006 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 326423006007 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 326423006008 YodL-like; Region: YodL; pfam14191 326423006009 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 326423006010 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 326423006011 active site 326423006012 YozD-like protein; Region: YozD; pfam14162 326423006013 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 326423006014 hypothetical protein; Provisional; Region: PRK13672 326423006015 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 326423006016 Zn binding site [ion binding]; other site 326423006017 toxin interface [polypeptide binding]; other site 326423006018 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 326423006019 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326423006020 FeS/SAM binding site; other site 326423006021 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 326423006022 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 326423006023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423006024 Coenzyme A binding pocket [chemical binding]; other site 326423006025 acetylornithine deacetylase; Validated; Region: PRK06915 326423006026 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 326423006027 metal binding site [ion binding]; metal-binding site 326423006028 dimer interface [polypeptide binding]; other site 326423006029 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 326423006030 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 326423006031 hypothetical protein; Provisional; Region: PRK06917 326423006032 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326423006033 inhibitor-cofactor binding pocket; inhibition site 326423006034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423006035 catalytic residue [active] 326423006036 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 326423006037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423006038 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 326423006039 Coenzyme A binding pocket [chemical binding]; other site 326423006040 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326423006041 active site 326423006042 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 326423006043 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326423006044 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 326423006045 Phytase; Region: Phytase; cl17685 326423006046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326423006047 NAD(P) binding site [chemical binding]; other site 326423006048 active site 326423006049 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 326423006050 YoqO-like protein; Region: YoqO; pfam14037 326423006051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 326423006052 TPR motif; other site 326423006053 binding surface 326423006054 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423006055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 326423006056 TPR motif; other site 326423006057 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423006058 Y-family of DNA polymerases; Region: PolY; cl12025 326423006059 DNA binding site [nucleotide binding] 326423006060 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 326423006061 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 326423006062 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 326423006063 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 326423006064 active site residue [active] 326423006065 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 326423006066 Response regulator receiver domain; Region: Response_reg; pfam00072 326423006067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423006068 active site 326423006069 phosphorylation site [posttranslational modification] 326423006070 intermolecular recognition site; other site 326423006071 dimerization interface [polypeptide binding]; other site 326423006072 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326423006073 DNA binding residues [nucleotide binding] 326423006074 PAS domain S-box; Region: sensory_box; TIGR00229 326423006075 PAS domain; Region: PAS_8; pfam13188 326423006076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 326423006077 Histidine kinase; Region: HisKA_3; pfam07730 326423006078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423006079 ATP binding site [chemical binding]; other site 326423006080 Mg2+ binding site [ion binding]; other site 326423006081 G-X-G motif; other site 326423006082 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 326423006083 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 326423006084 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 326423006085 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 326423006086 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 326423006087 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 326423006088 catalytic residues [active] 326423006089 catalytic nucleophile [active] 326423006090 Recombinase; Region: Recombinase; pfam07508 326423006091 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 326423006092 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 326423006093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326423006094 active site 326423006095 methionine sulfoxide reductase B; Provisional; Region: PRK00222 326423006096 SelR domain; Region: SelR; pfam01641 326423006097 methionine sulfoxide reductase A; Provisional; Region: PRK14054 326423006098 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423006099 MarR family; Region: MarR; pfam01047 326423006100 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 326423006101 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 326423006102 active site 326423006103 catalytic triad [active] 326423006104 oxyanion hole [active] 326423006105 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 326423006106 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 326423006107 Cu(I) binding site [ion binding]; other site 326423006108 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 326423006109 threonine dehydratase; Validated; Region: PRK08639 326423006110 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 326423006111 tetramer interface [polypeptide binding]; other site 326423006112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423006113 catalytic residue [active] 326423006114 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 326423006115 putative Ile/Val binding site [chemical binding]; other site 326423006116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423006117 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326423006118 Walker A motif; other site 326423006119 ATP binding site [chemical binding]; other site 326423006120 Walker B motif; other site 326423006121 arginine finger; other site 326423006122 Haemolysin-III related; Region: HlyIII; cl03831 326423006123 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 326423006124 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 326423006125 putative acyl-acceptor binding pocket; other site 326423006126 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 326423006127 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 326423006128 folate binding site [chemical binding]; other site 326423006129 NADP+ binding site [chemical binding]; other site 326423006130 thymidylate synthase; Reviewed; Region: thyA; PRK01827 326423006131 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 326423006132 dimerization interface [polypeptide binding]; other site 326423006133 active site 326423006134 YpjP-like protein; Region: YpjP; pfam14005 326423006135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326423006136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423006137 S-adenosylmethionine binding site [chemical binding]; other site 326423006138 Disulphide isomerase; Region: Disulph_isomer; pfam06491 326423006139 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 326423006140 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 326423006141 Virulence factor; Region: Virulence_fact; pfam13769 326423006142 HEAT repeats; Region: HEAT_2; pfam13646 326423006143 HEAT repeats; Region: HEAT_2; pfam13646 326423006144 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 326423006145 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 326423006146 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326423006147 Zn2+ binding site [ion binding]; other site 326423006148 Mg2+ binding site [ion binding]; other site 326423006149 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 326423006150 catalytic residues [active] 326423006151 dimer interface [polypeptide binding]; other site 326423006152 homoserine O-succinyltransferase; Provisional; Region: PRK05368 326423006153 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 326423006154 proposed active site lysine [active] 326423006155 conserved cys residue [active] 326423006156 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 326423006157 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 326423006158 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326423006159 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 326423006160 DNA-binding site [nucleotide binding]; DNA binding site 326423006161 RNA-binding motif; other site 326423006162 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 326423006163 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 326423006164 hypothetical protein; Validated; Region: PRK07708 326423006165 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 326423006166 RNA/DNA hybrid binding site [nucleotide binding]; other site 326423006167 active site 326423006168 conserved hypothetical integral membrane protein; Region: TIGR00697 326423006169 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 326423006170 RNA/DNA hybrid binding site [nucleotide binding]; other site 326423006171 active site 326423006172 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 326423006173 5'-3' exonuclease; Region: 53EXOc; smart00475 326423006174 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 326423006175 active site 326423006176 metal binding site 1 [ion binding]; metal-binding site 326423006177 putative 5' ssDNA interaction site; other site 326423006178 metal binding site 3; metal-binding site 326423006179 metal binding site 2 [ion binding]; metal-binding site 326423006180 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 326423006181 putative DNA binding site [nucleotide binding]; other site 326423006182 putative metal binding site [ion binding]; other site 326423006183 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 326423006184 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 326423006185 Dynamin family; Region: Dynamin_N; pfam00350 326423006186 G1 box; other site 326423006187 GTP/Mg2+ binding site [chemical binding]; other site 326423006188 G2 box; other site 326423006189 Switch I region; other site 326423006190 G3 box; other site 326423006191 Switch II region; other site 326423006192 G4 box; other site 326423006193 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 326423006194 G1 box; other site 326423006195 GTP/Mg2+ binding site [chemical binding]; other site 326423006196 Dynamin family; Region: Dynamin_N; pfam00350 326423006197 G2 box; other site 326423006198 Switch I region; other site 326423006199 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 326423006200 G3 box; other site 326423006201 Switch II region; other site 326423006202 GTP/Mg2+ binding site [chemical binding]; other site 326423006203 G4 box; other site 326423006204 G5 box; other site 326423006205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 326423006206 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 326423006207 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 326423006208 malonyl-CoA binding site [chemical binding]; other site 326423006209 dimer interface [polypeptide binding]; other site 326423006210 active site 326423006211 product binding site; other site 326423006212 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326423006213 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 326423006214 DNA binding site [nucleotide binding] 326423006215 active site 326423006216 Predicted membrane protein [Function unknown]; Region: COG2323 326423006217 Isochorismatase family; Region: Isochorismatase; pfam00857 326423006218 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 326423006219 catalytic triad [active] 326423006220 conserved cis-peptide bond; other site 326423006221 xanthine permease; Region: pbuX; TIGR03173 326423006222 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326423006223 active site 326423006224 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 326423006225 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 326423006226 active site 326423006227 Zn binding site [ion binding]; other site 326423006228 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 326423006229 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 326423006230 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 326423006231 YpzG-like protein; Region: YpzG; pfam14139 326423006232 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 326423006233 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 326423006234 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 326423006235 cell division protein GpsB; Provisional; Region: PRK14127 326423006236 DivIVA domain; Region: DivI1A_domain; TIGR03544 326423006237 hypothetical protein; Provisional; Region: PRK13660 326423006238 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 326423006239 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 326423006240 RNase_H superfamily; Region: RNase_H_2; pfam13482 326423006241 active site 326423006242 substrate binding site [chemical binding]; other site 326423006243 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 326423006244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326423006245 ATP binding site [chemical binding]; other site 326423006246 putative Mg++ binding site [ion binding]; other site 326423006247 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326423006248 nucleotide binding region [chemical binding]; other site 326423006249 ATP-binding site [chemical binding]; other site 326423006250 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 326423006251 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 326423006252 HPr interaction site; other site 326423006253 glycerol kinase (GK) interaction site [polypeptide binding]; other site 326423006254 active site 326423006255 phosphorylation site [posttranslational modification] 326423006256 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 326423006257 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 326423006258 putative dimer interface [polypeptide binding]; other site 326423006259 YppG-like protein; Region: YppG; pfam14179 326423006260 YppF-like protein; Region: YppF; pfam14178 326423006261 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 326423006262 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 326423006263 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 326423006264 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 326423006265 Transglycosylase; Region: Transgly; pfam00912 326423006266 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326423006267 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 326423006268 Interdomain contacts; other site 326423006269 Cytokine receptor motif; other site 326423006270 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 326423006271 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 326423006272 minor groove reading motif; other site 326423006273 helix-hairpin-helix signature motif; other site 326423006274 substrate binding pocket [chemical binding]; other site 326423006275 active site 326423006276 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 326423006277 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 326423006278 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 326423006279 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 326423006280 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 326423006281 putative dimer interface [polypeptide binding]; other site 326423006282 putative anticodon binding site; other site 326423006283 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 326423006284 homodimer interface [polypeptide binding]; other site 326423006285 motif 1; other site 326423006286 motif 2; other site 326423006287 active site 326423006288 motif 3; other site 326423006289 aspartate aminotransferase; Provisional; Region: PRK05764 326423006290 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326423006291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423006292 homodimer interface [polypeptide binding]; other site 326423006293 catalytic residue [active] 326423006294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 326423006295 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 326423006296 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 326423006297 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 326423006298 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 326423006299 active site 326423006300 catalytic site [active] 326423006301 substrate binding site [chemical binding]; other site 326423006302 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 326423006303 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 326423006304 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 326423006305 tetramerization interface [polypeptide binding]; other site 326423006306 active site 326423006307 Pantoate-beta-alanine ligase; Region: PanC; cd00560 326423006308 pantoate--beta-alanine ligase; Region: panC; TIGR00018 326423006309 active site 326423006310 ATP-binding site [chemical binding]; other site 326423006311 pantoate-binding site; other site 326423006312 HXXH motif; other site 326423006313 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 326423006314 oligomerization interface [polypeptide binding]; other site 326423006315 active site 326423006316 metal binding site [ion binding]; metal-binding site 326423006317 Biotin operon repressor [Transcription]; Region: BirA; COG1654 326423006318 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 326423006319 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 326423006320 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 326423006321 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 326423006322 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 326423006323 active site 326423006324 NTP binding site [chemical binding]; other site 326423006325 metal binding triad [ion binding]; metal-binding site 326423006326 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 326423006327 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 326423006328 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 326423006329 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 326423006330 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 326423006331 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 326423006332 active site 326423006333 dimer interfaces [polypeptide binding]; other site 326423006334 catalytic residues [active] 326423006335 dihydrodipicolinate reductase; Region: dapB; TIGR00036 326423006336 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 326423006337 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 326423006338 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 326423006339 homodimer interface [polypeptide binding]; other site 326423006340 metal binding site [ion binding]; metal-binding site 326423006341 Uncharacterized conserved protein [Function unknown]; Region: COG1284 326423006342 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423006343 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423006344 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 326423006345 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 326423006346 Cupin; Region: Cupin_1; smart00835 326423006347 Cupin; Region: Cupin_1; smart00835 326423006348 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 326423006349 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 326423006350 Qo binding site; other site 326423006351 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 326423006352 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 326423006353 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 326423006354 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 326423006355 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 326423006356 interchain domain interface [polypeptide binding]; other site 326423006357 intrachain domain interface; other site 326423006358 heme bH binding site [chemical binding]; other site 326423006359 Qi binding site; other site 326423006360 heme bL binding site [chemical binding]; other site 326423006361 Qo binding site; other site 326423006362 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 326423006363 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 326423006364 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 326423006365 iron-sulfur cluster [ion binding]; other site 326423006366 [2Fe-2S] cluster binding site [ion binding]; other site 326423006367 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 326423006368 hypothetical protein; Provisional; Region: PRK03636 326423006369 UPF0302 domain; Region: UPF0302; pfam08864 326423006370 A short protein domain of unknown function; Region: IDEAL; smart00914 326423006371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 326423006372 TPR motif; other site 326423006373 binding surface 326423006374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 326423006375 binding surface 326423006376 TPR motif; other site 326423006377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326423006378 TPR motif; other site 326423006379 binding surface 326423006380 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 326423006381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326423006382 binding surface 326423006383 TPR motif; other site 326423006384 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 326423006385 binding surface 326423006386 TPR motif; other site 326423006387 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 326423006388 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 326423006389 hinge; other site 326423006390 active site 326423006391 prephenate dehydrogenase; Validated; Region: PRK06545 326423006392 prephenate dehydrogenase; Validated; Region: PRK08507 326423006393 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 326423006394 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 326423006395 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326423006396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423006397 homodimer interface [polypeptide binding]; other site 326423006398 catalytic residue [active] 326423006399 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 326423006400 substrate binding site [chemical binding]; other site 326423006401 active site 326423006402 catalytic residues [active] 326423006403 heterodimer interface [polypeptide binding]; other site 326423006404 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 326423006405 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 326423006406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423006407 catalytic residue [active] 326423006408 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 326423006409 active site 326423006410 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 326423006411 active site 326423006412 ribulose/triose binding site [chemical binding]; other site 326423006413 phosphate binding site [ion binding]; other site 326423006414 substrate (anthranilate) binding pocket [chemical binding]; other site 326423006415 product (indole) binding pocket [chemical binding]; other site 326423006416 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 326423006417 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 326423006418 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 326423006419 anthranilate synthase component I; Provisional; Region: PRK13569 326423006420 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 326423006421 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 326423006422 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 326423006423 homotrimer interaction site [polypeptide binding]; other site 326423006424 active site 326423006425 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 326423006426 active site 326423006427 dimer interface [polypeptide binding]; other site 326423006428 metal binding site [ion binding]; metal-binding site 326423006429 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 326423006430 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 326423006431 Tetramer interface [polypeptide binding]; other site 326423006432 active site 326423006433 FMN-binding site [chemical binding]; other site 326423006434 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 326423006435 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 326423006436 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 326423006437 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 326423006438 active site 326423006439 multimer interface [polypeptide binding]; other site 326423006440 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 326423006441 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 326423006442 substrate binding pocket [chemical binding]; other site 326423006443 chain length determination region; other site 326423006444 substrate-Mg2+ binding site; other site 326423006445 catalytic residues [active] 326423006446 aspartate-rich region 1; other site 326423006447 active site lid residues [active] 326423006448 aspartate-rich region 2; other site 326423006449 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 326423006450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423006451 S-adenosylmethionine binding site [chemical binding]; other site 326423006452 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 326423006453 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 326423006454 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 326423006455 homodecamer interface [polypeptide binding]; other site 326423006456 GTP cyclohydrolase I; Provisional; Region: PLN03044 326423006457 active site 326423006458 putative catalytic site residues [active] 326423006459 zinc binding site [ion binding]; other site 326423006460 GTP-CH-I/GFRP interaction surface; other site 326423006461 histone-like DNA-binding protein HU; Region: HU; cd13831 326423006462 dimer interface [polypeptide binding]; other site 326423006463 DNA binding site [nucleotide binding] 326423006464 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 326423006465 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 326423006466 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 326423006467 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 326423006468 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 326423006469 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 326423006470 GTP-binding protein Der; Reviewed; Region: PRK00093 326423006471 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 326423006472 G1 box; other site 326423006473 GTP/Mg2+ binding site [chemical binding]; other site 326423006474 Switch I region; other site 326423006475 G2 box; other site 326423006476 Switch II region; other site 326423006477 G3 box; other site 326423006478 G4 box; other site 326423006479 G5 box; other site 326423006480 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 326423006481 G1 box; other site 326423006482 GTP/Mg2+ binding site [chemical binding]; other site 326423006483 Switch I region; other site 326423006484 G2 box; other site 326423006485 G3 box; other site 326423006486 Switch II region; other site 326423006487 G4 box; other site 326423006488 G5 box; other site 326423006489 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 326423006490 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 326423006491 homotetramer interface [polypeptide binding]; other site 326423006492 FMN binding site [chemical binding]; other site 326423006493 homodimer contacts [polypeptide binding]; other site 326423006494 putative active site [active] 326423006495 putative substrate binding site [chemical binding]; other site 326423006496 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 326423006497 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 326423006498 RNA binding site [nucleotide binding]; other site 326423006499 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 326423006500 RNA binding site [nucleotide binding]; other site 326423006501 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 326423006502 RNA binding site [nucleotide binding]; other site 326423006503 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 326423006504 RNA binding site [nucleotide binding]; other site 326423006505 cytidylate kinase; Provisional; Region: cmk; PRK00023 326423006506 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 326423006507 CMP-binding site; other site 326423006508 The sites determining sugar specificity; other site 326423006509 similar to hypothetical protein YpfA, contains internal stop 326423006510 germination protein YpeB; Region: spore_YpeB; TIGR02889 326423006511 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 326423006512 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326423006513 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 326423006514 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 326423006515 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 326423006516 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 326423006517 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 326423006518 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 326423006519 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 326423006520 NAD(P) binding site [chemical binding]; other site 326423006521 adaptor protein; Provisional; Region: PRK02899 326423006522 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 326423006523 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 326423006524 putative active site [active] 326423006525 putative metal binding site [ion binding]; other site 326423006526 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 326423006527 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 326423006528 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423006529 CAAX protease self-immunity; Region: Abi; pfam02517 326423006530 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 326423006531 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326423006532 ATP binding site [chemical binding]; other site 326423006533 putative Mg++ binding site [ion binding]; other site 326423006534 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326423006535 nucleotide binding region [chemical binding]; other site 326423006536 ATP-binding site [chemical binding]; other site 326423006537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 326423006538 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 326423006539 Predicted membrane protein [Function unknown]; Region: COG3601 326423006540 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 326423006541 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 326423006542 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 326423006543 ligand binding site [chemical binding]; other site 326423006544 NAD binding site [chemical binding]; other site 326423006545 dimerization interface [polypeptide binding]; other site 326423006546 catalytic site [active] 326423006547 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 326423006548 putative L-serine binding site [chemical binding]; other site 326423006549 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 326423006550 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326423006551 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423006552 DNA binding residues [nucleotide binding] 326423006553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 326423006554 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326423006555 dimerization interface [polypeptide binding]; other site 326423006556 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326423006557 putative active site [active] 326423006558 heme pocket [chemical binding]; other site 326423006559 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423006560 dimer interface [polypeptide binding]; other site 326423006561 phosphorylation site [posttranslational modification] 326423006562 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423006563 ATP binding site [chemical binding]; other site 326423006564 Mg2+ binding site [ion binding]; other site 326423006565 G-X-G motif; other site 326423006566 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423006567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423006568 active site 326423006569 phosphorylation site [posttranslational modification] 326423006570 intermolecular recognition site; other site 326423006571 dimerization interface [polypeptide binding]; other site 326423006572 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423006573 DNA binding site [nucleotide binding] 326423006574 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 326423006575 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 326423006576 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 326423006577 ResB-like family; Region: ResB; pfam05140 326423006578 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 326423006579 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 326423006580 catalytic residues [active] 326423006581 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 326423006582 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326423006583 RNA binding surface [nucleotide binding]; other site 326423006584 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 326423006585 active site 326423006586 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 326423006587 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 326423006588 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 326423006589 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 326423006590 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 326423006591 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 326423006592 segregation and condensation protein B; Region: TIGR00281 326423006593 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 326423006594 Domain of unknown function (DUF309); Region: DUF309; pfam03745 326423006595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423006596 Coenzyme A binding pocket [chemical binding]; other site 326423006597 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 326423006598 homopentamer interface [polypeptide binding]; other site 326423006599 active site 326423006600 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 326423006601 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 326423006602 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 326423006603 dimerization interface [polypeptide binding]; other site 326423006604 active site 326423006605 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 326423006606 Lumazine binding domain; Region: Lum_binding; pfam00677 326423006607 Lumazine binding domain; Region: Lum_binding; pfam00677 326423006608 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 326423006609 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 326423006610 catalytic motif [active] 326423006611 Zn binding site [ion binding]; other site 326423006612 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 326423006613 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 326423006614 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 326423006615 Catalytic site [active] 326423006616 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 326423006617 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 326423006618 active site 326423006619 Predicted secreted protein [Function unknown]; Region: COG4086 326423006620 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 326423006621 diaminopimelate decarboxylase; Region: lysA; TIGR01048 326423006622 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 326423006623 active site 326423006624 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 326423006625 substrate binding site [chemical binding]; other site 326423006626 catalytic residues [active] 326423006627 dimer interface [polypeptide binding]; other site 326423006628 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 326423006629 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 326423006630 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 326423006631 stage V sporulation protein AD; Validated; Region: PRK08304 326423006632 stage V sporulation protein AD; Provisional; Region: PRK12404 326423006633 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 326423006634 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 326423006635 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 326423006636 sporulation sigma factor SigF; Validated; Region: PRK05572 326423006637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326423006638 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 326423006639 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423006640 DNA binding residues [nucleotide binding] 326423006641 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 326423006642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423006643 ATP binding site [chemical binding]; other site 326423006644 Mg2+ binding site [ion binding]; other site 326423006645 G-X-G motif; other site 326423006646 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 326423006647 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 326423006648 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 326423006649 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 326423006650 purine nucleoside phosphorylase; Provisional; Region: PRK08202 326423006651 phosphopentomutase; Provisional; Region: PRK05362 326423006652 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 326423006653 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 326423006654 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 326423006655 active site 326423006656 Int/Topo IB signature motif; other site 326423006657 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 326423006658 ferric uptake regulator; Provisional; Region: fur; PRK09462 326423006659 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 326423006660 metal binding site 2 [ion binding]; metal-binding site 326423006661 putative DNA binding helix; other site 326423006662 metal binding site 1 [ion binding]; metal-binding site 326423006663 dimer interface [polypeptide binding]; other site 326423006664 structural Zn2+ binding site [ion binding]; other site 326423006665 stage II sporulation protein M; Region: spo_II_M; TIGR02831 326423006666 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 326423006667 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 326423006668 Malic enzyme, N-terminal domain; Region: malic; pfam00390 326423006669 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 326423006670 NAD(P) binding pocket [chemical binding]; other site 326423006671 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 326423006672 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 326423006673 Aspartase; Region: Aspartase; cd01357 326423006674 active sites [active] 326423006675 tetramer interface [polypeptide binding]; other site 326423006676 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 326423006677 active site 326423006678 homodimer interface [polypeptide binding]; other site 326423006679 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326423006680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326423006681 non-specific DNA binding site [nucleotide binding]; other site 326423006682 salt bridge; other site 326423006683 sequence-specific DNA binding site [nucleotide binding]; other site 326423006684 TIGR00375 family protein; Region: TIGR00375 326423006685 PHP-associated; Region: PHP_C; pfam13263 326423006686 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 326423006687 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 326423006688 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 326423006689 dimer interface [polypeptide binding]; other site 326423006690 ADP-ribose binding site [chemical binding]; other site 326423006691 active site 326423006692 nudix motif; other site 326423006693 metal binding site [ion binding]; metal-binding site 326423006694 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326423006695 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326423006696 active site 326423006697 catalytic tetrad [active] 326423006698 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326423006699 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326423006700 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 326423006701 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 326423006702 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 326423006703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 326423006704 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 326423006705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423006706 Coenzyme A binding pocket [chemical binding]; other site 326423006707 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 326423006708 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 326423006709 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 326423006710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423006711 Coenzyme A binding pocket [chemical binding]; other site 326423006712 DNA polymerase IV; Reviewed; Region: PRK03103 326423006713 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 326423006714 active site 326423006715 DNA binding site [nucleotide binding] 326423006716 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 326423006717 YolD-like protein; Region: YolD; pfam08863 326423006718 YqzH-like protein; Region: YqzH; pfam14164 326423006719 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 326423006720 Domain of unknown function DUF20; Region: UPF0118; pfam01594 326423006721 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 326423006722 putative dimer interface [polypeptide binding]; other site 326423006723 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326423006724 ligand binding site [chemical binding]; other site 326423006725 Zn binding site [ion binding]; other site 326423006726 pantothenate kinase; Provisional; Region: PRK05439 326423006727 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 326423006728 ATP-binding site [chemical binding]; other site 326423006729 CoA-binding site [chemical binding]; other site 326423006730 Mg2+-binding site [ion binding]; other site 326423006731 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 326423006732 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 326423006733 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326423006734 catalytic residue [active] 326423006735 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 326423006736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326423006737 NAD(P) binding site [chemical binding]; other site 326423006738 active site 326423006739 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 326423006740 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 326423006741 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 326423006742 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 326423006743 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326423006744 substrate binding site [chemical binding]; other site 326423006745 oxyanion hole (OAH) forming residues; other site 326423006746 trimer interface [polypeptide binding]; other site 326423006747 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 326423006748 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 326423006749 dimer interface [polypeptide binding]; other site 326423006750 active site 326423006751 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326423006752 Cytochrome P450; Region: p450; cl12078 326423006753 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326423006754 Methyltransferase domain; Region: Methyltransf_12; pfam08242 326423006755 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423006756 polyketide synthase; Region: polyketide_synthase; cd08251 326423006757 Enoylreductase; Region: PKS_ER; smart00829 326423006758 putative NAD(P) binding site [chemical binding]; other site 326423006759 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423006760 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423006761 active site 326423006762 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423006763 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423006764 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 326423006765 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423006766 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423006767 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326423006768 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423006769 active site 326423006770 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423006771 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423006772 putative NADP binding site [chemical binding]; other site 326423006773 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423006774 active site 326423006775 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423006776 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423006777 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423006778 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423006779 putative NADP binding site [chemical binding]; other site 326423006780 active site 326423006781 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423006782 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423006783 active site 326423006784 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423006785 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423006786 putative NADP binding site [chemical binding]; other site 326423006787 active site 326423006788 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423006789 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423006790 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423006791 active site 326423006792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423006793 S-adenosylmethionine binding site [chemical binding]; other site 326423006794 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423006795 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423006796 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423006797 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423006798 active site 326423006799 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423006800 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423006801 KR domain; Region: KR; pfam08659 326423006802 putative NADP binding site [chemical binding]; other site 326423006803 active site 326423006804 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423006805 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423006806 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423006807 active site 326423006808 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423006809 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423006810 putative NADP binding site [chemical binding]; other site 326423006811 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423006812 active site 326423006813 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423006814 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 326423006815 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423006816 active site 326423006817 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423006818 putative NADP binding site [chemical binding]; other site 326423006819 active site 326423006820 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423006821 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423006822 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423006823 active site 326423006824 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423006825 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423006826 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423006827 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423006828 active site 326423006829 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423006830 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423006831 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423006832 putative NADP binding site [chemical binding]; other site 326423006833 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423006834 active site 326423006835 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423006836 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423006837 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423006838 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423006839 active site 326423006840 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423006841 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423006842 putative NADP binding site [chemical binding]; other site 326423006843 active site 326423006844 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423006845 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423006846 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423006847 active site 326423006848 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423006849 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423006850 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423006851 active site 326423006852 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423006853 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423006854 putative NADP binding site [chemical binding]; other site 326423006855 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423006856 active site 326423006857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423006858 S-adenosylmethionine binding site [chemical binding]; other site 326423006859 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 326423006860 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423006861 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423006862 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423006863 active site 326423006864 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326423006865 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326423006866 putative NADP binding site [chemical binding]; other site 326423006867 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326423006868 active site 326423006869 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423006870 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423006871 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 326423006872 active site 326423006873 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 326423006874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326423006875 NAD(P) binding site [chemical binding]; other site 326423006876 active site 326423006877 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 326423006878 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 326423006879 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 326423006880 acyl-activating enzyme (AAE) consensus motif; other site 326423006881 acyl-activating enzyme (AAE) consensus motif; other site 326423006882 active site 326423006883 AMP binding site [chemical binding]; other site 326423006884 CoA binding site [chemical binding]; other site 326423006885 Phosphopantetheine attachment site; Region: PP-binding; cl09936 326423006886 biosynthesis cluster domain; Region: biosyn_clust_1; TIGR04098 326423006887 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 326423006888 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326423006889 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 326423006890 FMN binding site [chemical binding]; other site 326423006891 substrate binding site [chemical binding]; other site 326423006892 putative catalytic residue [active] 326423006893 Transcription antiterminator [Transcription]; Region: NusG; COG0250 326423006894 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 326423006895 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423006896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423006897 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326423006898 dimerization interface [polypeptide binding]; other site 326423006899 GlpM protein; Region: GlpM; cl01212 326423006900 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 326423006901 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 326423006902 active site 326423006903 FMN binding site [chemical binding]; other site 326423006904 substrate binding site [chemical binding]; other site 326423006905 homotetramer interface [polypeptide binding]; other site 326423006906 catalytic residue [active] 326423006907 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326423006908 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 326423006909 ribonuclease Z; Region: RNase_Z; TIGR02651 326423006910 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 326423006911 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 326423006912 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 326423006913 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 326423006914 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 326423006915 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 326423006916 DNA polymerase IV; Validated; Region: PRK01810 326423006917 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 326423006918 active site 326423006919 DNA binding site [nucleotide binding] 326423006920 OxaA-like protein precursor; Validated; Region: PRK01622 326423006921 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 326423006922 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 326423006923 peptidase T-like protein; Region: PepT-like; TIGR01883 326423006924 metal binding site [ion binding]; metal-binding site 326423006925 putative dimer interface [polypeptide binding]; other site 326423006926 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 326423006927 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 326423006928 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 326423006929 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326423006930 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 326423006931 dimer interface [polypeptide binding]; other site 326423006932 substrate binding site [chemical binding]; other site 326423006933 metal binding site [ion binding]; metal-binding site 326423006934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 326423006935 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 326423006936 Predicted membrane protein [Function unknown]; Region: COG4129 326423006937 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 326423006938 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 326423006939 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326423006940 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326423006941 Walker A/P-loop; other site 326423006942 ATP binding site [chemical binding]; other site 326423006943 Q-loop/lid; other site 326423006944 ABC transporter signature motif; other site 326423006945 Walker B; other site 326423006946 D-loop; other site 326423006947 H-loop/switch region; other site 326423006948 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 326423006949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423006950 dimer interface [polypeptide binding]; other site 326423006951 conserved gate region; other site 326423006952 putative PBP binding loops; other site 326423006953 ABC-ATPase subunit interface; other site 326423006954 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326423006955 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326423006956 substrate binding pocket [chemical binding]; other site 326423006957 membrane-bound complex binding site; other site 326423006958 hinge residues; other site 326423006959 Disulphide isomerase; Region: Disulph_isomer; pfam06491 326423006960 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 326423006961 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 326423006962 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 326423006963 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 326423006964 E3 interaction surface; other site 326423006965 lipoyl attachment site [posttranslational modification]; other site 326423006966 e3 binding domain; Region: E3_binding; pfam02817 326423006967 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 326423006968 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 326423006969 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 326423006970 alpha subunit interface [polypeptide binding]; other site 326423006971 TPP binding site [chemical binding]; other site 326423006972 heterodimer interface [polypeptide binding]; other site 326423006973 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 326423006974 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 326423006975 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 326423006976 tetramer interface [polypeptide binding]; other site 326423006977 TPP-binding site [chemical binding]; other site 326423006978 heterodimer interface [polypeptide binding]; other site 326423006979 phosphorylation loop region [posttranslational modification] 326423006980 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 326423006981 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 326423006982 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326423006983 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 326423006984 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 326423006985 nucleotide binding site [chemical binding]; other site 326423006986 Acetokinase family; Region: Acetate_kinase; cl17229 326423006987 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 326423006988 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 326423006989 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 326423006990 NAD binding site [chemical binding]; other site 326423006991 Phe binding site; other site 326423006992 phosphate butyryltransferase; Validated; Region: PRK07742 326423006993 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 326423006994 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 326423006995 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326423006996 putative active site [active] 326423006997 heme pocket [chemical binding]; other site 326423006998 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326423006999 putative active site [active] 326423007000 heme pocket [chemical binding]; other site 326423007001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423007002 Walker A motif; other site 326423007003 ATP binding site [chemical binding]; other site 326423007004 Walker B motif; other site 326423007005 arginine finger; other site 326423007006 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 326423007007 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 326423007008 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 326423007009 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 326423007010 tetramer interface [polypeptide binding]; other site 326423007011 active site 326423007012 Mg2+/Mn2+ binding site [ion binding]; other site 326423007013 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 326423007014 2-methylcitrate dehydratase; Region: prpD; TIGR02330 326423007015 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 326423007016 dimer interface [polypeptide binding]; other site 326423007017 Citrate synthase; Region: Citrate_synt; pfam00285 326423007018 active site 326423007019 coenzyme A binding site [chemical binding]; other site 326423007020 citrylCoA binding site [chemical binding]; other site 326423007021 oxalacetate/citrate binding site [chemical binding]; other site 326423007022 catalytic triad [active] 326423007023 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326423007024 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 326423007025 FAD binding site [chemical binding]; other site 326423007026 homotetramer interface [polypeptide binding]; other site 326423007027 substrate binding pocket [chemical binding]; other site 326423007028 catalytic base [active] 326423007029 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 326423007030 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 326423007031 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 326423007032 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 326423007033 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 326423007034 dimer interface [polypeptide binding]; other site 326423007035 active site 326423007036 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 326423007037 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 326423007038 active site 326423007039 catalytic site [active] 326423007040 metal binding site [ion binding]; metal-binding site 326423007041 dimer interface [polypeptide binding]; other site 326423007042 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 326423007043 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 326423007044 active site 326423007045 metal binding site [ion binding]; metal-binding site 326423007046 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 326423007047 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326423007048 sequence-specific DNA binding site [nucleotide binding]; other site 326423007049 salt bridge; other site 326423007050 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 326423007051 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 326423007052 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 326423007053 putative active site [active] 326423007054 putative FMN binding site [chemical binding]; other site 326423007055 putative substrate binding site [chemical binding]; other site 326423007056 putative catalytic residue [active] 326423007057 alanine racemase; Region: alr; TIGR00492 326423007058 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 326423007059 active site 326423007060 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 326423007061 dimer interface [polypeptide binding]; other site 326423007062 substrate binding site [chemical binding]; other site 326423007063 catalytic residues [active] 326423007064 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 326423007065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423007066 active site 326423007067 phosphorylation site [posttranslational modification] 326423007068 intermolecular recognition site; other site 326423007069 dimerization interface [polypeptide binding]; other site 326423007070 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 326423007071 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 326423007072 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 326423007073 protein binding site [polypeptide binding]; other site 326423007074 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 326423007075 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 326423007076 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 326423007077 Walker A/P-loop; other site 326423007078 ATP binding site [chemical binding]; other site 326423007079 Q-loop/lid; other site 326423007080 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 326423007081 ABC transporter signature motif; other site 326423007082 Walker B; other site 326423007083 D-loop; other site 326423007084 H-loop/switch region; other site 326423007085 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 326423007086 arginine repressor; Provisional; Region: PRK04280 326423007087 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 326423007088 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 326423007089 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326423007090 RNA binding surface [nucleotide binding]; other site 326423007091 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 326423007092 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 326423007093 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 326423007094 TPP-binding site; other site 326423007095 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 326423007096 PYR/PP interface [polypeptide binding]; other site 326423007097 dimer interface [polypeptide binding]; other site 326423007098 TPP binding site [chemical binding]; other site 326423007099 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 326423007100 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 326423007101 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 326423007102 substrate binding pocket [chemical binding]; other site 326423007103 chain length determination region; other site 326423007104 substrate-Mg2+ binding site; other site 326423007105 catalytic residues [active] 326423007106 aspartate-rich region 1; other site 326423007107 active site lid residues [active] 326423007108 aspartate-rich region 2; other site 326423007109 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 326423007110 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 326423007111 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 326423007112 generic binding surface II; other site 326423007113 generic binding surface I; other site 326423007114 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 326423007115 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 326423007116 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 326423007117 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 326423007118 homodimer interface [polypeptide binding]; other site 326423007119 NADP binding site [chemical binding]; other site 326423007120 substrate binding site [chemical binding]; other site 326423007121 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 326423007122 putative RNA binding site [nucleotide binding]; other site 326423007123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 326423007124 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 326423007125 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326423007126 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326423007127 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 326423007128 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 326423007129 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 326423007130 carboxyltransferase (CT) interaction site; other site 326423007131 biotinylation site [posttranslational modification]; other site 326423007132 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 326423007133 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 326423007134 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 326423007135 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 326423007136 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 326423007137 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 326423007138 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 326423007139 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 326423007140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423007141 Walker A motif; other site 326423007142 ATP binding site [chemical binding]; other site 326423007143 Walker B motif; other site 326423007144 Sulfatase; Region: Sulfatase; cl17466 326423007145 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 326423007146 elongation factor P; Validated; Region: PRK00529 326423007147 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 326423007148 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 326423007149 RNA binding site [nucleotide binding]; other site 326423007150 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 326423007151 RNA binding site [nucleotide binding]; other site 326423007152 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 326423007153 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 326423007154 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 326423007155 active site 326423007156 Conserved membrane protein YqhR; Region: YqhR; pfam11085 326423007157 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 326423007158 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 326423007159 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 326423007160 active site 326423007161 nucleophile elbow; other site 326423007162 manganese transport transcriptional regulator; Provisional; Region: PRK03902 326423007163 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 326423007164 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 326423007165 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 326423007166 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 326423007167 active site residue [active] 326423007168 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 326423007169 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 326423007170 tetramer interface [polypeptide binding]; other site 326423007171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423007172 catalytic residue [active] 326423007173 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 326423007174 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 326423007175 tetramer interface [polypeptide binding]; other site 326423007176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423007177 catalytic residue [active] 326423007178 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 326423007179 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 326423007180 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 326423007181 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 326423007182 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326423007183 ATP binding site [chemical binding]; other site 326423007184 putative Mg++ binding site [ion binding]; other site 326423007185 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326423007186 nucleotide binding region [chemical binding]; other site 326423007187 ATP-binding site [chemical binding]; other site 326423007188 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 326423007189 Anti-repressor SinI; Region: SinI; pfam08671 326423007190 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326423007191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326423007192 non-specific DNA binding site [nucleotide binding]; other site 326423007193 salt bridge; other site 326423007194 sequence-specific DNA binding site [nucleotide binding]; other site 326423007195 Anti-repressor SinI; Region: SinI; pfam08671 326423007196 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 326423007197 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 326423007198 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 326423007199 Catalytic site [active] 326423007200 YqxM protein; Region: YqxM_for_SipW; TIGR04087 326423007201 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 326423007202 YqzE-like protein; Region: YqzE; pfam14038 326423007203 ComG operon protein 7; Region: ComGG; pfam14173 326423007204 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 326423007205 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 326423007206 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 326423007207 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 326423007208 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 326423007209 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 326423007210 Type II/IV secretion system protein; Region: T2SE; pfam00437 326423007211 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 326423007212 Walker A motif; other site 326423007213 ATP binding site [chemical binding]; other site 326423007214 Walker B motif; other site 326423007215 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 326423007216 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 326423007217 Cl binding site [ion binding]; other site 326423007218 oligomer interface [polypeptide binding]; other site 326423007219 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 326423007220 Domain of unknown function DUF21; Region: DUF21; pfam01595 326423007221 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 326423007222 Transporter associated domain; Region: CorC_HlyC; smart01091 326423007223 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 326423007224 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 326423007225 ArsC family; Region: ArsC; pfam03960 326423007226 putative catalytic residues [active] 326423007227 thiol/disulfide switch; other site 326423007228 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 326423007229 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326423007230 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 326423007231 Uncharacterized conserved protein [Function unknown]; Region: COG0011 326423007232 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 326423007233 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 326423007234 putative active site [active] 326423007235 Zn binding site [ion binding]; other site 326423007236 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 326423007237 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 326423007238 nucleotide binding site [chemical binding]; other site 326423007239 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 326423007240 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 326423007241 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 326423007242 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 326423007243 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 326423007244 YceG-like family; Region: YceG; pfam02618 326423007245 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 326423007246 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 326423007247 Walker A/P-loop; other site 326423007248 ATP binding site [chemical binding]; other site 326423007249 Q-loop/lid; other site 326423007250 ABC transporter signature motif; other site 326423007251 Walker B; other site 326423007252 D-loop; other site 326423007253 H-loop/switch region; other site 326423007254 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 326423007255 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 326423007256 Walker A/P-loop; other site 326423007257 ATP binding site [chemical binding]; other site 326423007258 Q-loop/lid; other site 326423007259 ABC transporter signature motif; other site 326423007260 Walker B; other site 326423007261 D-loop; other site 326423007262 H-loop/switch region; other site 326423007263 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 326423007264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423007265 dimer interface [polypeptide binding]; other site 326423007266 conserved gate region; other site 326423007267 ABC-ATPase subunit interface; other site 326423007268 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 326423007269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423007270 dimer interface [polypeptide binding]; other site 326423007271 conserved gate region; other site 326423007272 putative PBP binding loops; other site 326423007273 ABC-ATPase subunit interface; other site 326423007274 PBP superfamily domain; Region: PBP_like_2; cl17296 326423007275 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 326423007276 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 326423007277 Homeodomain-like domain; Region: HTH_23; pfam13384 326423007278 putative transposase OrfB; Reviewed; Region: PHA02517 326423007279 HTH-like domain; Region: HTH_21; pfam13276 326423007280 Integrase core domain; Region: rve; pfam00665 326423007281 Integrase core domain; Region: rve_3; pfam13683 326423007282 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 326423007283 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 326423007284 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326423007285 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423007286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423007287 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 326423007288 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 326423007289 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 326423007290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 326423007291 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 326423007292 Lysin motif; Region: LysM; smart00257 326423007293 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 326423007294 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 326423007295 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 326423007296 Uncharacterized conserved protein [Function unknown]; Region: COG5663 326423007297 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 326423007298 metal binding site 2 [ion binding]; metal-binding site 326423007299 putative DNA binding helix; other site 326423007300 metal binding site 1 [ion binding]; metal-binding site 326423007301 dimer interface [polypeptide binding]; other site 326423007302 structural Zn2+ binding site [ion binding]; other site 326423007303 Uncharacterized conserved protein [Function unknown]; Region: COG1284 326423007304 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423007305 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 326423007306 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 326423007307 endonuclease IV; Provisional; Region: PRK01060 326423007308 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 326423007309 AP (apurinic/apyrimidinic) site pocket; other site 326423007310 DNA interaction; other site 326423007311 Metal-binding active site; metal-binding site 326423007312 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 326423007313 DEAD-like helicases superfamily; Region: DEXDc; smart00487 326423007314 ATP binding site [chemical binding]; other site 326423007315 Mg++ binding site [ion binding]; other site 326423007316 motif III; other site 326423007317 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326423007318 nucleotide binding region [chemical binding]; other site 326423007319 ATP-binding site [chemical binding]; other site 326423007320 YqfQ-like protein; Region: YqfQ; pfam14181 326423007321 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 326423007322 LytB protein; Region: LYTB; pfam02401 326423007323 Uncharacterized conserved protein [Function unknown]; Region: COG0327 326423007324 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 326423007325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 326423007326 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 326423007327 Uncharacterized conserved protein [Function unknown]; Region: COG0327 326423007328 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 326423007329 Family of unknown function (DUF633); Region: DUF633; pfam04816 326423007330 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 326423007331 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 326423007332 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 326423007333 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 326423007334 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 326423007335 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326423007336 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 326423007337 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423007338 DNA binding residues [nucleotide binding] 326423007339 DNA primase; Validated; Region: dnaG; PRK05667 326423007340 CHC2 zinc finger; Region: zf-CHC2; pfam01807 326423007341 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 326423007342 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 326423007343 active site 326423007344 metal binding site [ion binding]; metal-binding site 326423007345 interdomain interaction site; other site 326423007346 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 326423007347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 326423007348 PEP synthetase regulatory protein; Provisional; Region: PRK05339 326423007349 HTH domain; Region: HTH_11; pfam08279 326423007350 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 326423007351 FOG: CBS domain [General function prediction only]; Region: COG0517 326423007352 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 326423007353 DALR anticodon binding domain; Region: DALR_1; pfam05746 326423007354 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 326423007355 dimer interface [polypeptide binding]; other site 326423007356 motif 1; other site 326423007357 active site 326423007358 motif 2; other site 326423007359 motif 3; other site 326423007360 Recombination protein O N terminal; Region: RecO_N; pfam11967 326423007361 DNA repair protein RecO; Region: reco; TIGR00613 326423007362 Recombination protein O C terminal; Region: RecO_C; pfam02565 326423007363 GTPase Era; Reviewed; Region: era; PRK00089 326423007364 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 326423007365 G1 box; other site 326423007366 GTP/Mg2+ binding site [chemical binding]; other site 326423007367 Switch I region; other site 326423007368 G2 box; other site 326423007369 Switch II region; other site 326423007370 G3 box; other site 326423007371 G4 box; other site 326423007372 G5 box; other site 326423007373 KH domain; Region: KH_2; pfam07650 326423007374 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 326423007375 active site 326423007376 catalytic motif [active] 326423007377 Zn binding site [ion binding]; other site 326423007378 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 326423007379 metal-binding heat shock protein; Provisional; Region: PRK00016 326423007380 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 326423007381 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 326423007382 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326423007383 Zn2+ binding site [ion binding]; other site 326423007384 Mg2+ binding site [ion binding]; other site 326423007385 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 326423007386 PhoH-like protein; Region: PhoH; pfam02562 326423007387 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 326423007388 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 326423007389 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 326423007390 hypothetical protein; Provisional; Region: PRK13665 326423007391 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 326423007392 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 326423007393 dimer interface [polypeptide binding]; other site 326423007394 active site residues [active] 326423007395 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 326423007396 Yqey-like protein; Region: YqeY; pfam09424 326423007397 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 326423007398 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 326423007399 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 326423007400 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 326423007401 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 326423007402 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 326423007403 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326423007404 FeS/SAM binding site; other site 326423007405 TRAM domain; Region: TRAM; cl01282 326423007406 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 326423007407 RNA methyltransferase, RsmE family; Region: TIGR00046 326423007408 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 326423007409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423007410 S-adenosylmethionine binding site [chemical binding]; other site 326423007411 chaperone protein DnaJ; Provisional; Region: PRK14280 326423007412 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 326423007413 HSP70 interaction site [polypeptide binding]; other site 326423007414 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 326423007415 substrate binding site [polypeptide binding]; other site 326423007416 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 326423007417 Zn binding sites [ion binding]; other site 326423007418 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 326423007419 dimer interface [polypeptide binding]; other site 326423007420 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 326423007421 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 326423007422 nucleotide binding site [chemical binding]; other site 326423007423 NEF interaction site [polypeptide binding]; other site 326423007424 SBD interface [polypeptide binding]; other site 326423007425 GrpE; Region: GrpE; pfam01025 326423007426 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 326423007427 dimer interface [polypeptide binding]; other site 326423007428 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 326423007429 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 326423007430 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 326423007431 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 326423007432 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326423007433 FeS/SAM binding site; other site 326423007434 HemN C-terminal domain; Region: HemN_C; pfam06969 326423007435 GTP-binding protein LepA; Provisional; Region: PRK05433 326423007436 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 326423007437 G1 box; other site 326423007438 putative GEF interaction site [polypeptide binding]; other site 326423007439 GTP/Mg2+ binding site [chemical binding]; other site 326423007440 Switch I region; other site 326423007441 G2 box; other site 326423007442 G3 box; other site 326423007443 Switch II region; other site 326423007444 G4 box; other site 326423007445 G5 box; other site 326423007446 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 326423007447 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 326423007448 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 326423007449 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 326423007450 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 326423007451 stage II sporulation protein P; Region: spore_II_P; TIGR02867 326423007452 germination protease; Provisional; Region: PRK02858 326423007453 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 326423007454 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 326423007455 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 326423007456 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 326423007457 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 326423007458 Competence protein; Region: Competence; pfam03772 326423007459 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326423007460 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 326423007461 catalytic motif [active] 326423007462 Zn binding site [ion binding]; other site 326423007463 SLBB domain; Region: SLBB; pfam10531 326423007464 comEA protein; Region: comE; TIGR01259 326423007465 Helix-hairpin-helix motif; Region: HHH; pfam00633 326423007466 late competence protein ComER; Validated; Region: PRK07680 326423007467 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 326423007468 Methyltransferase domain; Region: Methyltransf_31; pfam13847 326423007469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423007470 S-adenosylmethionine binding site [chemical binding]; other site 326423007471 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 326423007472 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326423007473 Zn2+ binding site [ion binding]; other site 326423007474 Mg2+ binding site [ion binding]; other site 326423007475 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 326423007476 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 326423007477 active site 326423007478 (T/H)XGH motif; other site 326423007479 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 326423007480 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 326423007481 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 326423007482 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 326423007483 shikimate binding site; other site 326423007484 NAD(P) binding site [chemical binding]; other site 326423007485 GTPase YqeH; Provisional; Region: PRK13796 326423007486 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 326423007487 GTP/Mg2+ binding site [chemical binding]; other site 326423007488 G4 box; other site 326423007489 G5 box; other site 326423007490 G1 box; other site 326423007491 Switch I region; other site 326423007492 G2 box; other site 326423007493 G3 box; other site 326423007494 Switch II region; other site 326423007495 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 326423007496 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423007497 active site 326423007498 motif I; other site 326423007499 motif II; other site 326423007500 Sporulation inhibitor A; Region: Sda; pfam08970 326423007501 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 326423007502 active site 326423007503 catalytic triad [active] 326423007504 oxyanion hole [active] 326423007505 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 326423007506 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 326423007507 Uncharacterized conserved protein [Function unknown]; Region: COG0398 326423007508 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 326423007509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423007510 H+ Antiporter protein; Region: 2A0121; TIGR00900 326423007511 putative substrate translocation pore; other site 326423007512 sporulation sigma factor SigK; Reviewed; Region: PRK05803 326423007513 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326423007514 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423007515 DNA binding residues [nucleotide binding] 326423007516 Domain of unknown function (DUF303); Region: DUF303; pfam03629 326423007517 Predicted transcriptional regulators [Transcription]; Region: COG1695 326423007518 Transcriptional regulator PadR-like family; Region: PadR; cl17335 326423007519 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 326423007520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423007521 HAMP domain; Region: HAMP; pfam00672 326423007522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423007523 dimer interface [polypeptide binding]; other site 326423007524 phosphorylation site [posttranslational modification] 326423007525 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423007526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423007527 active site 326423007528 phosphorylation site [posttranslational modification] 326423007529 intermolecular recognition site; other site 326423007530 dimerization interface [polypeptide binding]; other site 326423007531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423007532 DNA binding site [nucleotide binding] 326423007533 Predicted membrane protein [Function unknown]; Region: COG2311 326423007534 Protein of unknown function (DUF418); Region: DUF418; cl12135 326423007535 Protein of unknown function (DUF418); Region: DUF418; pfam04235 326423007536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423007537 Coenzyme A binding pocket [chemical binding]; other site 326423007538 hypothetical protein; Validated; Region: PRK06217 326423007539 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 326423007540 DinB family; Region: DinB; pfam05163 326423007541 DinB superfamily; Region: DinB_2; pfam12867 326423007542 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 326423007543 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326423007544 active site 326423007545 motif I; other site 326423007546 motif II; other site 326423007547 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 326423007548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423007549 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326423007550 active site 326423007551 motif I; other site 326423007552 motif II; other site 326423007553 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 326423007554 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 326423007555 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 326423007556 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 326423007557 putative active site [active] 326423007558 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 326423007559 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 326423007560 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 326423007561 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 326423007562 active site 326423007563 P-loop; other site 326423007564 phosphorylation site [posttranslational modification] 326423007565 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 326423007566 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 326423007567 active site 326423007568 phosphorylation site [posttranslational modification] 326423007569 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 326423007570 HTH domain; Region: HTH_11; cl17392 326423007571 PRD domain; Region: PRD; pfam00874 326423007572 PRD domain; Region: PRD; pfam00874 326423007573 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 326423007574 active site 326423007575 P-loop; other site 326423007576 phosphorylation site [posttranslational modification] 326423007577 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 326423007578 active site 326423007579 phosphorylation site [posttranslational modification] 326423007580 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 326423007581 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 326423007582 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 326423007583 putative deacylase active site [active] 326423007584 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423007585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423007586 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 326423007587 putative dimerization interface [polypeptide binding]; other site 326423007588 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 326423007589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423007590 putative substrate translocation pore; other site 326423007591 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 326423007592 Cytochrome P450; Region: p450; pfam00067 326423007593 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 326423007594 Flavodoxin; Region: Flavodoxin_1; pfam00258 326423007595 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 326423007596 FAD binding pocket [chemical binding]; other site 326423007597 FAD binding motif [chemical binding]; other site 326423007598 catalytic residues [active] 326423007599 NAD binding pocket [chemical binding]; other site 326423007600 phosphate binding motif [ion binding]; other site 326423007601 beta-alpha-beta structure motif; other site 326423007602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423007603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423007604 Methyltransferase domain; Region: Methyltransf_11; pfam08241 326423007605 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 326423007606 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 326423007607 Uncharacterized conserved protein [Function unknown]; Region: COG5609 326423007608 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 326423007609 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 326423007610 catalytic loop [active] 326423007611 iron binding site [ion binding]; other site 326423007612 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 326423007613 4Fe-4S binding domain; Region: Fer4; pfam00037 326423007614 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 326423007615 [4Fe-4S] binding site [ion binding]; other site 326423007616 molybdopterin cofactor binding site; other site 326423007617 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 326423007618 molybdopterin cofactor binding site; other site 326423007619 Uncharacterized conserved protein [Function unknown]; Region: COG2427 326423007620 YrhC-like protein; Region: YrhC; pfam14143 326423007621 cystathionine beta-lyase; Provisional; Region: PRK07671 326423007622 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 326423007623 homodimer interface [polypeptide binding]; other site 326423007624 substrate-cofactor binding pocket; other site 326423007625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423007626 catalytic residue [active] 326423007627 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 326423007628 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 326423007629 dimer interface [polypeptide binding]; other site 326423007630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423007631 catalytic residue [active] 326423007632 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 326423007633 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 326423007634 Methyltransferase domain; Region: Methyltransf_11; pfam08241 326423007635 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 326423007636 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 326423007637 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 326423007638 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 326423007639 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326423007640 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 326423007641 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 326423007642 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 326423007643 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 326423007644 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 326423007645 ATP-binding site [chemical binding]; other site 326423007646 Sugar specificity; other site 326423007647 Pyrimidine base specificity; other site 326423007648 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 326423007649 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326423007650 Peptidase family U32; Region: Peptidase_U32; pfam01136 326423007651 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 326423007652 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326423007653 Peptidase family U32; Region: Peptidase_U32; pfam01136 326423007654 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 326423007655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423007656 S-adenosylmethionine binding site [chemical binding]; other site 326423007657 conserved hypothetical protein, YceG family; Region: TIGR00247 326423007658 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 326423007659 dimerization interface [polypeptide binding]; other site 326423007660 hypothetical protein; Provisional; Region: PRK13678 326423007661 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 326423007662 hypothetical protein; Provisional; Region: PRK05473 326423007663 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 326423007664 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 326423007665 motif 1; other site 326423007666 active site 326423007667 motif 2; other site 326423007668 motif 3; other site 326423007669 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 326423007670 DHHA1 domain; Region: DHHA1; pfam02272 326423007671 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 326423007672 Domain of unknown function DUF20; Region: UPF0118; pfam01594 326423007673 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326423007674 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326423007675 Walker A/P-loop; other site 326423007676 ATP binding site [chemical binding]; other site 326423007677 Q-loop/lid; other site 326423007678 ABC transporter signature motif; other site 326423007679 Walker B; other site 326423007680 D-loop; other site 326423007681 H-loop/switch region; other site 326423007682 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 326423007683 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326423007684 substrate binding pocket [chemical binding]; other site 326423007685 membrane-bound complex binding site; other site 326423007686 hinge residues; other site 326423007687 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 326423007688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423007689 dimer interface [polypeptide binding]; other site 326423007690 conserved gate region; other site 326423007691 putative PBP binding loops; other site 326423007692 ABC-ATPase subunit interface; other site 326423007693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423007694 dimer interface [polypeptide binding]; other site 326423007695 conserved gate region; other site 326423007696 putative PBP binding loops; other site 326423007697 ABC-ATPase subunit interface; other site 326423007698 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 326423007699 PRC-barrel domain; Region: PRC; pfam05239 326423007700 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 326423007701 AAA domain; Region: AAA_30; pfam13604 326423007702 Family description; Region: UvrD_C_2; pfam13538 326423007703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326423007704 binding surface 326423007705 TPR repeat; Region: TPR_11; pfam13414 326423007706 TPR motif; other site 326423007707 TPR repeat; Region: TPR_11; pfam13414 326423007708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326423007709 binding surface 326423007710 TPR motif; other site 326423007711 TPR repeat; Region: TPR_11; pfam13414 326423007712 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 326423007713 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 326423007714 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 326423007715 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 326423007716 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326423007717 catalytic residue [active] 326423007718 Predicted transcriptional regulator [Transcription]; Region: COG1959 326423007719 Transcriptional regulator; Region: Rrf2; pfam02082 326423007720 recombination factor protein RarA; Reviewed; Region: PRK13342 326423007721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423007722 Walker A motif; other site 326423007723 ATP binding site [chemical binding]; other site 326423007724 Walker B motif; other site 326423007725 arginine finger; other site 326423007726 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 326423007727 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 326423007728 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 326423007729 putative ATP binding site [chemical binding]; other site 326423007730 putative substrate interface [chemical binding]; other site 326423007731 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 326423007732 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 326423007733 dimer interface [polypeptide binding]; other site 326423007734 anticodon binding site; other site 326423007735 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 326423007736 homodimer interface [polypeptide binding]; other site 326423007737 motif 1; other site 326423007738 active site 326423007739 motif 2; other site 326423007740 GAD domain; Region: GAD; pfam02938 326423007741 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 326423007742 active site 326423007743 motif 3; other site 326423007744 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 326423007745 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 326423007746 dimer interface [polypeptide binding]; other site 326423007747 motif 1; other site 326423007748 active site 326423007749 motif 2; other site 326423007750 motif 3; other site 326423007751 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 326423007752 anticodon binding site; other site 326423007753 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 326423007754 Bacterial SH3 domain; Region: SH3_3; pfam08239 326423007755 Bacterial SH3 domain; Region: SH3_3; pfam08239 326423007756 Bacterial SH3 domain; Region: SH3_3; pfam08239 326423007757 Bacterial SH3 domain homologues; Region: SH3b; smart00287 326423007758 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 326423007759 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 326423007760 active site 326423007761 metal binding site [ion binding]; metal-binding site 326423007762 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 326423007763 putative active site [active] 326423007764 dimerization interface [polypeptide binding]; other site 326423007765 putative tRNAtyr binding site [nucleotide binding]; other site 326423007766 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 326423007767 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326423007768 Zn2+ binding site [ion binding]; other site 326423007769 Mg2+ binding site [ion binding]; other site 326423007770 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 326423007771 synthetase active site [active] 326423007772 NTP binding site [chemical binding]; other site 326423007773 metal binding site [ion binding]; metal-binding site 326423007774 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 326423007775 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 326423007776 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326423007777 active site 326423007778 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 326423007779 DHH family; Region: DHH; pfam01368 326423007780 DHHA1 domain; Region: DHHA1; pfam02272 326423007781 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 326423007782 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 326423007783 TrkA-C domain; Region: TrkA_C; pfam02080 326423007784 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 326423007785 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 326423007786 RDD family; Region: RDD; pfam06271 326423007787 Protein export membrane protein; Region: SecD_SecF; pfam02355 326423007788 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 326423007789 stage V sporulation protein B; Region: spore_V_B; TIGR02900 326423007790 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 326423007791 Predicted membrane protein [Function unknown]; Region: COG2323 326423007792 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 326423007793 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 326423007794 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 326423007795 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 326423007796 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 326423007797 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 326423007798 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 326423007799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423007800 Walker A motif; other site 326423007801 ATP binding site [chemical binding]; other site 326423007802 Walker B motif; other site 326423007803 arginine finger; other site 326423007804 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 326423007805 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 326423007806 RuvA N terminal domain; Region: RuvA_N; pfam01330 326423007807 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 326423007808 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 326423007809 BofC C-terminal domain; Region: BofC_C; pfam08955 326423007810 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 326423007811 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 326423007812 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423007813 quinolinate synthetase; Provisional; Region: PRK09375 326423007814 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 326423007815 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 326423007816 dimerization interface [polypeptide binding]; other site 326423007817 active site 326423007818 L-aspartate oxidase; Provisional; Region: PRK08071 326423007819 L-aspartate oxidase; Provisional; Region: PRK06175 326423007820 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 326423007821 cysteine desulfurase; Provisional; Region: PRK02948 326423007822 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 326423007823 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326423007824 catalytic residue [active] 326423007825 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 326423007826 HTH domain; Region: HTH_11; pfam08279 326423007827 3H domain; Region: 3H; pfam02829 326423007828 prephenate dehydratase; Provisional; Region: PRK11898 326423007829 Prephenate dehydratase; Region: PDT; pfam00800 326423007830 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 326423007831 putative L-Phe binding site [chemical binding]; other site 326423007832 hypothetical protein; Provisional; Region: PRK04435 326423007833 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 326423007834 GTPase CgtA; Reviewed; Region: obgE; PRK12297 326423007835 GTP1/OBG; Region: GTP1_OBG; pfam01018 326423007836 Obg GTPase; Region: Obg; cd01898 326423007837 G1 box; other site 326423007838 GTP/Mg2+ binding site [chemical binding]; other site 326423007839 Switch I region; other site 326423007840 G2 box; other site 326423007841 G3 box; other site 326423007842 Switch II region; other site 326423007843 G4 box; other site 326423007844 G5 box; other site 326423007845 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 326423007846 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 326423007847 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 326423007848 hypothetical protein; Provisional; Region: PRK14553 326423007849 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 326423007850 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 326423007851 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 326423007852 Peptidase family M50; Region: Peptidase_M50; pfam02163 326423007853 active site 326423007854 putative substrate binding region [chemical binding]; other site 326423007855 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 326423007856 Peptidase family M23; Region: Peptidase_M23; pfam01551 326423007857 septum site-determining protein MinD; Region: minD_bact; TIGR01968 326423007858 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 326423007859 Switch I; other site 326423007860 Switch II; other site 326423007861 septum formation inhibitor; Reviewed; Region: minC; PRK00513 326423007862 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 326423007863 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 326423007864 rod shape-determining protein MreC; Region: mreC; TIGR00219 326423007865 rod shape-determining protein MreC; Region: MreC; pfam04085 326423007866 rod shape-determining protein MreB; Provisional; Region: PRK13927 326423007867 MreB and similar proteins; Region: MreB_like; cd10225 326423007868 nucleotide binding site [chemical binding]; other site 326423007869 Mg binding site [ion binding]; other site 326423007870 putative protofilament interaction site [polypeptide binding]; other site 326423007871 RodZ interaction site [polypeptide binding]; other site 326423007872 hypothetical protein; Reviewed; Region: PRK00024 326423007873 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 326423007874 MPN+ (JAMM) motif; other site 326423007875 Zinc-binding site [ion binding]; other site 326423007876 Maf-like protein; Region: Maf; pfam02545 326423007877 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 326423007878 active site 326423007879 dimer interface [polypeptide binding]; other site 326423007880 Sporulation related domain; Region: SPOR; pfam05036 326423007881 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 326423007882 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 326423007883 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 326423007884 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 326423007885 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326423007886 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326423007887 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 326423007888 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326423007889 active site 326423007890 HIGH motif; other site 326423007891 nucleotide binding site [chemical binding]; other site 326423007892 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 326423007893 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 326423007894 active site 326423007895 KMSKS motif; other site 326423007896 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 326423007897 tRNA binding surface [nucleotide binding]; other site 326423007898 anticodon binding site; other site 326423007899 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 326423007900 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 326423007901 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 326423007902 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 326423007903 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326423007904 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 326423007905 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326423007906 inhibitor-cofactor binding pocket; inhibition site 326423007907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423007908 catalytic residue [active] 326423007909 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 326423007910 dimer interface [polypeptide binding]; other site 326423007911 active site 326423007912 Schiff base residues; other site 326423007913 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 326423007914 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 326423007915 active site 326423007916 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 326423007917 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 326423007918 domain interfaces; other site 326423007919 active site 326423007920 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 326423007921 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 326423007922 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 326423007923 tRNA; other site 326423007924 putative tRNA binding site [nucleotide binding]; other site 326423007925 putative NADP binding site [chemical binding]; other site 326423007926 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 326423007927 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 326423007928 G1 box; other site 326423007929 GTP/Mg2+ binding site [chemical binding]; other site 326423007930 Switch I region; other site 326423007931 G2 box; other site 326423007932 G3 box; other site 326423007933 Switch II region; other site 326423007934 G4 box; other site 326423007935 G5 box; other site 326423007936 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 326423007937 Found in ATP-dependent protease La (LON); Region: LON; smart00464 326423007938 Found in ATP-dependent protease La (LON); Region: LON; smart00464 326423007939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423007940 Walker A motif; other site 326423007941 ATP binding site [chemical binding]; other site 326423007942 Walker B motif; other site 326423007943 arginine finger; other site 326423007944 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 326423007945 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 326423007946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423007947 Walker A motif; other site 326423007948 ATP binding site [chemical binding]; other site 326423007949 Walker B motif; other site 326423007950 arginine finger; other site 326423007951 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 326423007952 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 326423007953 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 326423007954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423007955 Walker A motif; other site 326423007956 ATP binding site [chemical binding]; other site 326423007957 Walker B motif; other site 326423007958 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 326423007959 trigger factor; Provisional; Region: tig; PRK01490 326423007960 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 326423007961 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 326423007962 TPR repeat; Region: TPR_11; pfam13414 326423007963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326423007964 binding surface 326423007965 TPR motif; other site 326423007966 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 326423007967 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 326423007968 substrate binding site [chemical binding]; other site 326423007969 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 326423007970 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 326423007971 substrate binding site [chemical binding]; other site 326423007972 ligand binding site [chemical binding]; other site 326423007973 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 326423007974 tartrate dehydrogenase; Region: TTC; TIGR02089 326423007975 2-isopropylmalate synthase; Validated; Region: PRK00915 326423007976 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 326423007977 active site 326423007978 catalytic residues [active] 326423007979 metal binding site [ion binding]; metal-binding site 326423007980 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 326423007981 ketol-acid reductoisomerase; Provisional; Region: PRK05479 326423007982 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 326423007983 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 326423007984 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 326423007985 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 326423007986 putative valine binding site [chemical binding]; other site 326423007987 dimer interface [polypeptide binding]; other site 326423007988 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 326423007989 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 326423007990 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 326423007991 PYR/PP interface [polypeptide binding]; other site 326423007992 dimer interface [polypeptide binding]; other site 326423007993 TPP binding site [chemical binding]; other site 326423007994 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 326423007995 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 326423007996 TPP-binding site [chemical binding]; other site 326423007997 dimer interface [polypeptide binding]; other site 326423007998 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 326423007999 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 326423008000 active site 326423008001 metal binding site [ion binding]; metal-binding site 326423008002 homotetramer interface [polypeptide binding]; other site 326423008003 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 326423008004 active site 326423008005 dimerization interface [polypeptide binding]; other site 326423008006 ribonuclease PH; Reviewed; Region: rph; PRK00173 326423008007 Ribonuclease PH; Region: RNase_PH_bact; cd11362 326423008008 hexamer interface [polypeptide binding]; other site 326423008009 active site 326423008010 Sporulation and spore germination; Region: Germane; pfam10646 326423008011 Spore germination protein [General function prediction only]; Region: COG5401 326423008012 Sporulation and spore germination; Region: Germane; pfam10646 326423008013 glutamate racemase; Provisional; Region: PRK00865 326423008014 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423008015 MarR family; Region: MarR; pfam01047 326423008016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326423008017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326423008018 DNA binding residues [nucleotide binding] 326423008019 dimerization interface [polypeptide binding]; other site 326423008020 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 326423008021 active site 326423008022 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 326423008023 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 326423008024 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 326423008025 L-aspartate oxidase; Provisional; Region: PRK06175 326423008026 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 326423008027 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 326423008028 putative Iron-sulfur protein interface [polypeptide binding]; other site 326423008029 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 326423008030 proximal heme binding site [chemical binding]; other site 326423008031 distal heme binding site [chemical binding]; other site 326423008032 putative dimer interface [polypeptide binding]; other site 326423008033 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 326423008034 aspartate kinase; Reviewed; Region: PRK06635 326423008035 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 326423008036 putative nucleotide binding site [chemical binding]; other site 326423008037 putative catalytic residues [active] 326423008038 putative Mg ion binding site [ion binding]; other site 326423008039 putative aspartate binding site [chemical binding]; other site 326423008040 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 326423008041 putative allosteric regulatory site; other site 326423008042 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 326423008043 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 326423008044 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 326423008045 GIY-YIG motif/motif A; other site 326423008046 active site 326423008047 catalytic site [active] 326423008048 putative DNA binding site [nucleotide binding]; other site 326423008049 metal binding site [ion binding]; metal-binding site 326423008050 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 326423008051 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 326423008052 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 326423008053 catalytic residues [active] 326423008054 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 326423008055 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 326423008056 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 326423008057 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 326423008058 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 326423008059 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 326423008060 Ligand binding site [chemical binding]; other site 326423008061 Electron transfer flavoprotein domain; Region: ETF; pfam01012 326423008062 enoyl-CoA hydratase; Provisional; Region: PRK07658 326423008063 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326423008064 substrate binding site [chemical binding]; other site 326423008065 oxyanion hole (OAH) forming residues; other site 326423008066 trimer interface [polypeptide binding]; other site 326423008067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423008068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423008069 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 326423008070 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 326423008071 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 326423008072 acyl-activating enzyme (AAE) consensus motif; other site 326423008073 putative AMP binding site [chemical binding]; other site 326423008074 putative active site [active] 326423008075 putative CoA binding site [chemical binding]; other site 326423008076 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 326423008077 Predicted membrane protein [Function unknown]; Region: COG3766 326423008078 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 326423008079 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 326423008080 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 326423008081 MutS domain III; Region: MutS_III; pfam05192 326423008082 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 326423008083 Walker A/P-loop; other site 326423008084 ATP binding site [chemical binding]; other site 326423008085 Q-loop/lid; other site 326423008086 ABC transporter signature motif; other site 326423008087 Walker B; other site 326423008088 D-loop; other site 326423008089 H-loop/switch region; other site 326423008090 Smr domain; Region: Smr; pfam01713 326423008091 hypothetical protein; Provisional; Region: PRK08609 326423008092 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 326423008093 active site 326423008094 primer binding site [nucleotide binding]; other site 326423008095 NTP binding site [chemical binding]; other site 326423008096 metal binding triad [ion binding]; metal-binding site 326423008097 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 326423008098 active site 326423008099 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 326423008100 Colicin V production protein; Region: Colicin_V; pfam02674 326423008101 cell division protein ZapA; Provisional; Region: PRK14126 326423008102 ribonuclease HIII; Provisional; Region: PRK00996 326423008103 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 326423008104 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 326423008105 RNA/DNA hybrid binding site [nucleotide binding]; other site 326423008106 active site 326423008107 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 326423008108 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 326423008109 putative tRNA-binding site [nucleotide binding]; other site 326423008110 B3/4 domain; Region: B3_4; pfam03483 326423008111 tRNA synthetase B5 domain; Region: B5; smart00874 326423008112 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 326423008113 dimer interface [polypeptide binding]; other site 326423008114 motif 1; other site 326423008115 motif 3; other site 326423008116 motif 2; other site 326423008117 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 326423008118 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 326423008119 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 326423008120 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 326423008121 dimer interface [polypeptide binding]; other site 326423008122 motif 1; other site 326423008123 active site 326423008124 motif 2; other site 326423008125 motif 3; other site 326423008126 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 326423008127 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 326423008128 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 326423008129 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 326423008130 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 326423008131 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 326423008132 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 326423008133 FAD binding domain; Region: FAD_binding_4; pfam01565 326423008134 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 326423008135 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 326423008136 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 326423008137 Cysteine-rich domain; Region: CCG; pfam02754 326423008138 Cysteine-rich domain; Region: CCG; pfam02754 326423008139 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 326423008140 Carbon starvation protein CstA; Region: CstA; pfam02554 326423008141 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 326423008142 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 326423008143 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 326423008144 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326423008145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423008146 putative PBP binding loops; other site 326423008147 dimer interface [polypeptide binding]; other site 326423008148 ABC-ATPase subunit interface; other site 326423008149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423008150 dimer interface [polypeptide binding]; other site 326423008151 conserved gate region; other site 326423008152 putative PBP binding loops; other site 326423008153 ABC-ATPase subunit interface; other site 326423008154 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326423008155 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326423008156 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 326423008157 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 326423008158 active site 326423008159 metal binding site [ion binding]; metal-binding site 326423008160 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 326423008161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423008162 active site 326423008163 motif I; other site 326423008164 motif II; other site 326423008165 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423008166 motif II; other site 326423008167 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 326423008168 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 326423008169 intersubunit interface [polypeptide binding]; other site 326423008170 active site 326423008171 Zn2+ binding site [ion binding]; other site 326423008172 ribulokinase; Provisional; Region: PRK04123 326423008173 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 326423008174 N- and C-terminal domain interface [polypeptide binding]; other site 326423008175 active site 326423008176 MgATP binding site [chemical binding]; other site 326423008177 catalytic site [active] 326423008178 metal binding site [ion binding]; metal-binding site 326423008179 carbohydrate binding site [chemical binding]; other site 326423008180 homodimer interface [polypeptide binding]; other site 326423008181 L-arabinose isomerase; Provisional; Region: PRK02929 326423008182 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 326423008183 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 326423008184 trimer interface [polypeptide binding]; other site 326423008185 putative substrate binding site [chemical binding]; other site 326423008186 putative metal binding site [ion binding]; other site 326423008187 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 326423008188 substrate binding site [chemical binding]; other site 326423008189 active site 326423008190 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 326423008191 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 326423008192 oligomer interface [polypeptide binding]; other site 326423008193 active site 326423008194 metal binding site [ion binding]; metal-binding site 326423008195 Predicted membrane protein [Function unknown]; Region: COG3326 326423008196 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 326423008197 23S rRNA binding site [nucleotide binding]; other site 326423008198 L21 binding site [polypeptide binding]; other site 326423008199 L13 binding site [polypeptide binding]; other site 326423008200 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 326423008201 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 326423008202 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 326423008203 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 326423008204 antiholin-like protein LrgB; Provisional; Region: PRK04288 326423008205 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 326423008206 two-component response regulator; Provisional; Region: PRK14084 326423008207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423008208 active site 326423008209 phosphorylation site [posttranslational modification] 326423008210 intermolecular recognition site; other site 326423008211 dimerization interface [polypeptide binding]; other site 326423008212 LytTr DNA-binding domain; Region: LytTR; smart00850 326423008213 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 326423008214 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 326423008215 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 326423008216 Histidine kinase; Region: His_kinase; pfam06580 326423008217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423008218 ATP binding site [chemical binding]; other site 326423008219 Mg2+ binding site [ion binding]; other site 326423008220 G-X-G motif; other site 326423008221 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 326423008222 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423008223 motif II; other site 326423008224 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 326423008225 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 326423008226 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 326423008227 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 326423008228 active site 326423008229 dimer interface [polypeptide binding]; other site 326423008230 motif 1; other site 326423008231 motif 2; other site 326423008232 motif 3; other site 326423008233 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 326423008234 anticodon binding site; other site 326423008235 YtxC-like family; Region: YtxC; pfam08812 326423008236 Uncharacterized conserved protein [Function unknown]; Region: COG0398 326423008237 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 326423008238 primosomal protein DnaI; Reviewed; Region: PRK08939 326423008239 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 326423008240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423008241 Walker A motif; other site 326423008242 ATP binding site [chemical binding]; other site 326423008243 Walker B motif; other site 326423008244 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 326423008245 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 326423008246 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 326423008247 ATP cone domain; Region: ATP-cone; pfam03477 326423008248 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 326423008249 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 326423008250 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 326423008251 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 326423008252 Predicted transcriptional regulators [Transcription]; Region: COG1733 326423008253 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326423008254 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 326423008255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423008256 putative substrate translocation pore; other site 326423008257 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326423008258 active site 326423008259 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326423008260 catalytic tetrad [active] 326423008261 dephospho-CoA kinase; Region: TIGR00152 326423008262 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 326423008263 CoA-binding site [chemical binding]; other site 326423008264 ATP-binding [chemical binding]; other site 326423008265 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 326423008266 Domain of unknown function DUF; Region: DUF204; pfam02659 326423008267 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 326423008268 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 326423008269 DNA binding site [nucleotide binding] 326423008270 catalytic residue [active] 326423008271 H2TH interface [polypeptide binding]; other site 326423008272 putative catalytic residues [active] 326423008273 turnover-facilitating residue; other site 326423008274 intercalation triad [nucleotide binding]; other site 326423008275 8OG recognition residue [nucleotide binding]; other site 326423008276 putative reading head residues; other site 326423008277 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 326423008278 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 326423008279 DNA polymerase I; Provisional; Region: PRK05755 326423008280 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 326423008281 active site 326423008282 metal binding site 1 [ion binding]; metal-binding site 326423008283 putative 5' ssDNA interaction site; other site 326423008284 metal binding site 3; metal-binding site 326423008285 metal binding site 2 [ion binding]; metal-binding site 326423008286 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 326423008287 putative DNA binding site [nucleotide binding]; other site 326423008288 putative metal binding site [ion binding]; other site 326423008289 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 326423008290 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 326423008291 active site 326423008292 DNA binding site [nucleotide binding] 326423008293 catalytic site [active] 326423008294 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 326423008295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326423008296 putative active site [active] 326423008297 heme pocket [chemical binding]; other site 326423008298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423008299 dimer interface [polypeptide binding]; other site 326423008300 phosphorylation site [posttranslational modification] 326423008301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423008302 ATP binding site [chemical binding]; other site 326423008303 Mg2+ binding site [ion binding]; other site 326423008304 G-X-G motif; other site 326423008305 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423008306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423008307 active site 326423008308 phosphorylation site [posttranslational modification] 326423008309 intermolecular recognition site; other site 326423008310 dimerization interface [polypeptide binding]; other site 326423008311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423008312 DNA binding site [nucleotide binding] 326423008313 malate dehydrogenase; Reviewed; Region: PRK06223 326423008314 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 326423008315 NAD(P) binding site [chemical binding]; other site 326423008316 dimer interface [polypeptide binding]; other site 326423008317 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326423008318 substrate binding site [chemical binding]; other site 326423008319 isocitrate dehydrogenase; Reviewed; Region: PRK07006 326423008320 isocitrate dehydrogenase; Validated; Region: PRK07362 326423008321 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 326423008322 dimer interface [polypeptide binding]; other site 326423008323 Citrate synthase; Region: Citrate_synt; pfam00285 326423008324 active site 326423008325 citrylCoA binding site [chemical binding]; other site 326423008326 oxalacetate/citrate binding site [chemical binding]; other site 326423008327 coenzyme A binding site [chemical binding]; other site 326423008328 catalytic triad [active] 326423008329 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 326423008330 Protein of unknown function (DUF441); Region: DUF441; pfam04284 326423008331 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 326423008332 Domain of unknown function DUF20; Region: UPF0118; pfam01594 326423008333 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 326423008334 pyruvate kinase; Provisional; Region: PRK06354 326423008335 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 326423008336 domain interfaces; other site 326423008337 active site 326423008338 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 326423008339 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 326423008340 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 326423008341 active site 326423008342 ADP/pyrophosphate binding site [chemical binding]; other site 326423008343 dimerization interface [polypeptide binding]; other site 326423008344 allosteric effector site; other site 326423008345 fructose-1,6-bisphosphate binding site; other site 326423008346 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 326423008347 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 326423008348 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 326423008349 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 326423008350 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 326423008351 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 326423008352 Malic enzyme, N-terminal domain; Region: malic; pfam00390 326423008353 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 326423008354 putative NAD(P) binding site [chemical binding]; other site 326423008355 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 326423008356 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 326423008357 active site 326423008358 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 326423008359 generic binding surface I; other site 326423008360 generic binding surface II; other site 326423008361 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 326423008362 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 326423008363 DHH family; Region: DHH; pfam01368 326423008364 DHHA1 domain; Region: DHHA1; pfam02272 326423008365 YtpI-like protein; Region: YtpI; pfam14007 326423008366 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 326423008367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423008368 DNA-binding site [nucleotide binding]; DNA binding site 326423008369 DRTGG domain; Region: DRTGG; pfam07085 326423008370 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 326423008371 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 326423008372 active site 2 [active] 326423008373 active site 1 [active] 326423008374 metal-dependent hydrolase; Provisional; Region: PRK00685 326423008375 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 326423008376 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 326423008377 classical (c) SDRs; Region: SDR_c; cd05233 326423008378 NAD(P) binding site [chemical binding]; other site 326423008379 active site 326423008380 argininosuccinate lyase; Provisional; Region: PRK00855 326423008381 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 326423008382 active sites [active] 326423008383 tetramer interface [polypeptide binding]; other site 326423008384 argininosuccinate synthase; Provisional; Region: PRK13820 326423008385 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 326423008386 ANP binding site [chemical binding]; other site 326423008387 Substrate Binding Site II [chemical binding]; other site 326423008388 Substrate Binding Site I [chemical binding]; other site 326423008389 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 326423008390 MPT binding site; other site 326423008391 trimer interface [polypeptide binding]; other site 326423008392 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 326423008393 propionate/acetate kinase; Provisional; Region: PRK12379 326423008394 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 326423008395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423008396 S-adenosylmethionine binding site [chemical binding]; other site 326423008397 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 326423008398 dimer interface [polypeptide binding]; other site 326423008399 catalytic triad [active] 326423008400 peroxidatic and resolving cysteines [active] 326423008401 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 326423008402 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 326423008403 RDD family; Region: RDD; pfam06271 326423008404 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 326423008405 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 326423008406 tandem repeat interface [polypeptide binding]; other site 326423008407 oligomer interface [polypeptide binding]; other site 326423008408 active site residues [active] 326423008409 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 326423008410 ATP-NAD kinase; Region: NAD_kinase; pfam01513 326423008411 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 326423008412 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 326423008413 active site 326423008414 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326423008415 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 326423008416 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 326423008417 active site 326423008418 acyl-activating enzyme (AAE) consensus motif; other site 326423008419 putative CoA binding site [chemical binding]; other site 326423008420 AMP binding site [chemical binding]; other site 326423008421 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 326423008422 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 326423008423 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 326423008424 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 326423008425 Ligand Binding Site [chemical binding]; other site 326423008426 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 326423008427 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 326423008428 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326423008429 catalytic residue [active] 326423008430 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 326423008431 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 326423008432 TMPIT-like protein; Region: TMPIT; pfam07851 326423008433 histidinol-phosphatase; Reviewed; Region: PRK08123 326423008434 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 326423008435 active site 326423008436 dimer interface [polypeptide binding]; other site 326423008437 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423008438 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423008439 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 326423008440 GAF domain; Region: GAF_2; pfam13185 326423008441 GAF domain; Region: GAF_3; pfam13492 326423008442 GAF domain; Region: GAF_2; pfam13185 326423008443 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326423008444 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326423008445 metal binding site [ion binding]; metal-binding site 326423008446 active site 326423008447 I-site; other site 326423008448 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 326423008449 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 326423008450 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326423008451 RNA binding surface [nucleotide binding]; other site 326423008452 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 326423008453 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 326423008454 NAD(P) binding site [chemical binding]; other site 326423008455 catalytic residues [active] 326423008456 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 326423008457 positive control sigma-like factor; Validated; Region: PRK06930 326423008458 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423008459 DNA binding residues [nucleotide binding] 326423008460 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 326423008461 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 326423008462 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 326423008463 heme-binding site [chemical binding]; other site 326423008464 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 326423008465 FAD binding pocket [chemical binding]; other site 326423008466 FAD binding motif [chemical binding]; other site 326423008467 phosphate binding motif [ion binding]; other site 326423008468 beta-alpha-beta structure motif; other site 326423008469 NAD binding pocket [chemical binding]; other site 326423008470 Heme binding pocket [chemical binding]; other site 326423008471 intracellular protease, PfpI family; Region: PfpI; TIGR01382 326423008472 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 326423008473 proposed catalytic triad [active] 326423008474 conserved cys residue [active] 326423008475 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 326423008476 active site 326423008477 catalytic triad [active] 326423008478 oxyanion hole [active] 326423008479 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 326423008480 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 326423008481 Predicted transcriptional regulators [Transcription]; Region: COG1378 326423008482 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 326423008483 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 326423008484 C-terminal domain interface [polypeptide binding]; other site 326423008485 sugar binding site [chemical binding]; other site 326423008486 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 326423008487 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 326423008488 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 326423008489 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 326423008490 active site 326423008491 HIGH motif; other site 326423008492 dimer interface [polypeptide binding]; other site 326423008493 KMSKS motif; other site 326423008494 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326423008495 RNA binding surface [nucleotide binding]; other site 326423008496 acetyl-CoA synthetase; Provisional; Region: PRK04319 326423008497 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 326423008498 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 326423008499 active site 326423008500 acyl-activating enzyme (AAE) consensus motif; other site 326423008501 putative CoA binding site [chemical binding]; other site 326423008502 AMP binding site [chemical binding]; other site 326423008503 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423008504 Coenzyme A binding pocket [chemical binding]; other site 326423008505 FOG: CBS domain [General function prediction only]; Region: COG0517 326423008506 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 326423008507 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 326423008508 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 326423008509 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 326423008510 active site 326423008511 Zn binding site [ion binding]; other site 326423008512 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 326423008513 flagellar motor protein MotS; Reviewed; Region: PRK06925 326423008514 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 326423008515 ligand binding site [chemical binding]; other site 326423008516 flagellar motor protein MotP; Reviewed; Region: PRK06926 326423008517 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 326423008518 catabolite control protein A; Region: ccpA; TIGR01481 326423008519 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326423008520 DNA binding site [nucleotide binding] 326423008521 domain linker motif; other site 326423008522 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 326423008523 dimerization interface [polypeptide binding]; other site 326423008524 effector binding site; other site 326423008525 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 326423008526 Chorismate mutase type II; Region: CM_2; cl00693 326423008527 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 326423008528 Protein of unknown function (DUF2847); Region: DUF2847; cl17683 326423008529 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 326423008530 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 326423008531 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 326423008532 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 326423008533 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326423008534 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326423008535 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 326423008536 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326423008537 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 326423008538 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 326423008539 putative tRNA-binding site [nucleotide binding]; other site 326423008540 hypothetical protein; Provisional; Region: PRK13668 326423008541 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 326423008542 catalytic residues [active] 326423008543 YtoQ family protein; Region: YtoQ_fam; TIGR03646 326423008544 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 326423008545 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 326423008546 oligomer interface [polypeptide binding]; other site 326423008547 active site 326423008548 metal binding site [ion binding]; metal-binding site 326423008549 Predicted small secreted protein [Function unknown]; Region: COG5584 326423008550 malate dehydrogenase; Provisional; Region: PRK13529 326423008551 Malic enzyme, N-terminal domain; Region: malic; pfam00390 326423008552 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 326423008553 NAD(P) binding site [chemical binding]; other site 326423008554 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 326423008555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423008556 S-adenosylmethionine binding site [chemical binding]; other site 326423008557 YtzH-like protein; Region: YtzH; pfam14165 326423008558 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 326423008559 active site 326423008560 ATP binding site [chemical binding]; other site 326423008561 Phosphotransferase enzyme family; Region: APH; pfam01636 326423008562 substrate binding site [chemical binding]; other site 326423008563 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 326423008564 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 326423008565 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 326423008566 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 326423008567 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 326423008568 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 326423008569 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 326423008570 dimer interface [polypeptide binding]; other site 326423008571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423008572 catalytic residue [active] 326423008573 dipeptidase PepV; Reviewed; Region: PRK07318 326423008574 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 326423008575 active site 326423008576 metal binding site [ion binding]; metal-binding site 326423008577 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 326423008578 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 326423008579 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 326423008580 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326423008581 Walker A/P-loop; other site 326423008582 ATP binding site [chemical binding]; other site 326423008583 Q-loop/lid; other site 326423008584 ABC transporter signature motif; other site 326423008585 Walker B; other site 326423008586 D-loop; other site 326423008587 H-loop/switch region; other site 326423008588 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 326423008589 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 326423008590 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 326423008591 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326423008592 RNA binding surface [nucleotide binding]; other site 326423008593 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 326423008594 active site 326423008595 uracil binding [chemical binding]; other site 326423008596 stage V sporulation protein B; Region: spore_V_B; TIGR02900 326423008597 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 326423008598 HI0933-like protein; Region: HI0933_like; pfam03486 326423008599 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326423008600 BCCT family transporter; Region: BCCT; pfam02028 326423008601 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 326423008602 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326423008603 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326423008604 DNA binding site [nucleotide binding] 326423008605 domain linker motif; other site 326423008606 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 326423008607 putative ligand binding site [chemical binding]; other site 326423008608 putative dimerization interface [polypeptide binding]; other site 326423008609 PBP superfamily domain; Region: PBP_like_2; cl17296 326423008610 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326423008611 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 326423008612 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 326423008613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423008614 dimer interface [polypeptide binding]; other site 326423008615 conserved gate region; other site 326423008616 putative PBP binding loops; other site 326423008617 ABC-ATPase subunit interface; other site 326423008618 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326423008619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423008620 dimer interface [polypeptide binding]; other site 326423008621 conserved gate region; other site 326423008622 putative PBP binding loops; other site 326423008623 ABC-ATPase subunit interface; other site 326423008624 alpha-galactosidase; Provisional; Region: PRK15076 326423008625 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 326423008626 NAD binding site [chemical binding]; other site 326423008627 sugar binding site [chemical binding]; other site 326423008628 divalent metal binding site [ion binding]; other site 326423008629 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 326423008630 dimer interface [polypeptide binding]; other site 326423008631 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 326423008632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423008633 Coenzyme A binding pocket [chemical binding]; other site 326423008634 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 326423008635 active site residue [active] 326423008636 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 326423008637 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 326423008638 HIGH motif; other site 326423008639 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 326423008640 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326423008641 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 326423008642 active site 326423008643 KMSKS motif; other site 326423008644 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 326423008645 tRNA binding surface [nucleotide binding]; other site 326423008646 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 326423008647 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326423008648 PAS domain; Region: PAS_9; pfam13426 326423008649 putative active site [active] 326423008650 heme pocket [chemical binding]; other site 326423008651 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 326423008652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423008653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423008654 putative substrate translocation pore; other site 326423008655 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 326423008656 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 326423008657 FtsX-like permease family; Region: FtsX; pfam02687 326423008658 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326423008659 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326423008660 Walker A/P-loop; other site 326423008661 ATP binding site [chemical binding]; other site 326423008662 Q-loop/lid; other site 326423008663 ABC transporter signature motif; other site 326423008664 Walker B; other site 326423008665 D-loop; other site 326423008666 H-loop/switch region; other site 326423008667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423008668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 326423008669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423008670 ATP binding site [chemical binding]; other site 326423008671 Mg2+ binding site [ion binding]; other site 326423008672 G-X-G motif; other site 326423008673 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423008674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423008675 active site 326423008676 phosphorylation site [posttranslational modification] 326423008677 intermolecular recognition site; other site 326423008678 dimerization interface [polypeptide binding]; other site 326423008679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423008680 DNA binding site [nucleotide binding] 326423008681 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326423008682 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 326423008683 FtsX-like permease family; Region: FtsX; pfam02687 326423008684 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326423008685 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326423008686 Walker A/P-loop; other site 326423008687 ATP binding site [chemical binding]; other site 326423008688 Q-loop/lid; other site 326423008689 ABC transporter signature motif; other site 326423008690 Walker B; other site 326423008691 D-loop; other site 326423008692 H-loop/switch region; other site 326423008693 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 326423008694 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 326423008695 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326423008696 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326423008697 Walker A/P-loop; other site 326423008698 ATP binding site [chemical binding]; other site 326423008699 Q-loop/lid; other site 326423008700 ABC transporter signature motif; other site 326423008701 Walker B; other site 326423008702 D-loop; other site 326423008703 H-loop/switch region; other site 326423008704 Predicted transcriptional regulators [Transcription]; Region: COG1725 326423008705 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423008706 DNA-binding site [nucleotide binding]; DNA binding site 326423008707 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 326423008708 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 326423008709 acyl-CoA synthetase; Validated; Region: PRK09192 326423008710 acyl-activating enzyme (AAE) consensus motif; other site 326423008711 putative AMP binding site [chemical binding]; other site 326423008712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326423008713 putative DNA binding site [nucleotide binding]; other site 326423008714 putative Zn2+ binding site [ion binding]; other site 326423008715 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326423008716 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 326423008717 active site 326423008718 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423008719 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326423008720 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423008721 Condensation domain; Region: Condensation; pfam00668 326423008722 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423008723 Nonribosomal peptide synthase; Region: NRPS; pfam08415 326423008724 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 326423008725 acyl-activating enzyme (AAE) consensus motif; other site 326423008726 AMP binding site [chemical binding]; other site 326423008727 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423008728 Condensation domain; Region: Condensation; pfam00668 326423008729 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423008730 Nonribosomal peptide synthase; Region: NRPS; pfam08415 326423008731 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 326423008732 acyl-activating enzyme (AAE) consensus motif; other site 326423008733 AMP binding site [chemical binding]; other site 326423008734 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423008735 Condensation domain; Region: Condensation; pfam00668 326423008736 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 326423008737 Nonribosomal peptide synthase; Region: NRPS; pfam08415 326423008738 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 326423008739 acyl-activating enzyme (AAE) consensus motif; other site 326423008740 AMP binding site [chemical binding]; other site 326423008741 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423008742 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 326423008743 putative FMN binding site [chemical binding]; other site 326423008744 NADPH bind site [chemical binding]; other site 326423008745 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 326423008746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423008747 putative substrate translocation pore; other site 326423008748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423008749 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 326423008750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423008751 S-adenosylmethionine binding site [chemical binding]; other site 326423008752 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 326423008753 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 326423008754 active site 326423008755 catalytic site [active] 326423008756 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 326423008757 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 326423008758 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326423008759 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 326423008760 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 326423008761 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 326423008762 trimer interface [polypeptide binding]; other site 326423008763 putative metal binding site [ion binding]; other site 326423008764 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 326423008765 Spore germination protein; Region: Spore_permease; cl17796 326423008766 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 326423008767 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 326423008768 active site 326423008769 dimer interface [polypeptide binding]; other site 326423008770 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 326423008771 Ligand Binding Site [chemical binding]; other site 326423008772 Molecular Tunnel; other site 326423008773 S-adenosylmethionine synthetase; Validated; Region: PRK05250 326423008774 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 326423008775 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 326423008776 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 326423008777 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 326423008778 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 326423008779 active site 326423008780 substrate-binding site [chemical binding]; other site 326423008781 metal-binding site [ion binding] 326423008782 ATP binding site [chemical binding]; other site 326423008783 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 326423008784 Dienelactone hydrolase family; Region: DLH; pfam01738 326423008785 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 326423008786 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 326423008787 NMT1-like family; Region: NMT1_2; pfam13379 326423008788 substrate binding pocket [chemical binding]; other site 326423008789 membrane-bound complex binding site; other site 326423008790 hinge residues; other site 326423008791 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 326423008792 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 326423008793 Walker A/P-loop; other site 326423008794 ATP binding site [chemical binding]; other site 326423008795 Q-loop/lid; other site 326423008796 ABC transporter signature motif; other site 326423008797 Walker B; other site 326423008798 D-loop; other site 326423008799 H-loop/switch region; other site 326423008800 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 326423008801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423008802 dimer interface [polypeptide binding]; other site 326423008803 conserved gate region; other site 326423008804 putative PBP binding loops; other site 326423008805 ABC-ATPase subunit interface; other site 326423008806 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 326423008807 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 326423008808 nudix motif; other site 326423008809 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 326423008810 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 326423008811 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 326423008812 dimerization interface [polypeptide binding]; other site 326423008813 DPS ferroxidase diiron center [ion binding]; other site 326423008814 ion pore; other site 326423008815 YtkA-like; Region: YtkA; pfam13115 326423008816 S-ribosylhomocysteinase; Provisional; Region: PRK02260 326423008817 Haemolytic domain; Region: Haemolytic; pfam01809 326423008818 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 326423008819 active site clefts [active] 326423008820 zinc binding site [ion binding]; other site 326423008821 dimer interface [polypeptide binding]; other site 326423008822 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 326423008823 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 326423008824 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 326423008825 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 326423008826 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 326423008827 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 326423008828 active site 326423008829 octamer interface [polypeptide binding]; other site 326423008830 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 326423008831 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 326423008832 acyl-activating enzyme (AAE) consensus motif; other site 326423008833 putative AMP binding site [chemical binding]; other site 326423008834 putative active site [active] 326423008835 putative CoA binding site [chemical binding]; other site 326423008836 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326423008837 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 326423008838 substrate binding site [chemical binding]; other site 326423008839 oxyanion hole (OAH) forming residues; other site 326423008840 trimer interface [polypeptide binding]; other site 326423008841 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 326423008842 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 326423008843 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 326423008844 dimer interface [polypeptide binding]; other site 326423008845 tetramer interface [polypeptide binding]; other site 326423008846 PYR/PP interface [polypeptide binding]; other site 326423008847 TPP binding site [chemical binding]; other site 326423008848 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 326423008849 TPP-binding site; other site 326423008850 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 326423008851 chorismate binding enzyme; Region: Chorismate_bind; cl10555 326423008852 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 326423008853 TspO/MBR family; Region: TspO_MBR; cl01379 326423008854 Predicted membrane protein [Function unknown]; Region: COG3859 326423008855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 326423008856 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 326423008857 DinB superfamily; Region: DinB_2; pfam12867 326423008858 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 326423008859 MOSC domain; Region: MOSC; pfam03473 326423008860 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 326423008861 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 326423008862 active site 326423008863 NAD binding site [chemical binding]; other site 326423008864 metal binding site [ion binding]; metal-binding site 326423008865 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 326423008866 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 326423008867 tetramerization interface [polypeptide binding]; other site 326423008868 NAD(P) binding site [chemical binding]; other site 326423008869 catalytic residues [active] 326423008870 Predicted transcriptional regulators [Transcription]; Region: COG1510 326423008871 MarR family; Region: MarR_2; pfam12802 326423008872 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 326423008873 TrkA-N domain; Region: TrkA_N; pfam02254 326423008874 TrkA-C domain; Region: TrkA_C; pfam02080 326423008875 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 326423008876 SH3-like domain; Region: SH3_8; pfam13457 326423008877 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 326423008878 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 326423008879 heme-binding site [chemical binding]; other site 326423008880 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 326423008881 FAD binding pocket [chemical binding]; other site 326423008882 FAD binding motif [chemical binding]; other site 326423008883 phosphate binding motif [ion binding]; other site 326423008884 beta-alpha-beta structure motif; other site 326423008885 NAD binding pocket [chemical binding]; other site 326423008886 Heme binding pocket [chemical binding]; other site 326423008887 Cupin; Region: Cupin_1; smart00835 326423008888 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 326423008889 Domain of unknown function DUF20; Region: UPF0118; pfam01594 326423008890 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 326423008891 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 326423008892 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 326423008893 intracellular protease, PfpI family; Region: PfpI; TIGR01382 326423008894 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 326423008895 proposed catalytic triad [active] 326423008896 conserved cys residue [active] 326423008897 Tar ligand binding domain homologue; Region: TarH; pfam02203 326423008898 Cache domain; Region: Cache_1; pfam02743 326423008899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326423008900 dimerization interface [polypeptide binding]; other site 326423008901 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 326423008902 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 326423008903 dimer interface [polypeptide binding]; other site 326423008904 putative CheW interface [polypeptide binding]; other site 326423008905 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 326423008906 Cache domain; Region: Cache_1; pfam02743 326423008907 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326423008908 dimerization interface [polypeptide binding]; other site 326423008909 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 326423008910 dimer interface [polypeptide binding]; other site 326423008911 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 326423008912 putative CheW interface [polypeptide binding]; other site 326423008913 Tar ligand binding domain homologue; Region: TarH; pfam02203 326423008914 Cache domain; Region: Cache_1; pfam02743 326423008915 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326423008916 dimerization interface [polypeptide binding]; other site 326423008917 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 326423008918 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 326423008919 dimer interface [polypeptide binding]; other site 326423008920 putative CheW interface [polypeptide binding]; other site 326423008921 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 326423008922 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 326423008923 Cache domain; Region: Cache_1; pfam02743 326423008924 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326423008925 dimerization interface [polypeptide binding]; other site 326423008926 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 326423008927 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 326423008928 dimer interface [polypeptide binding]; other site 326423008929 putative CheW interface [polypeptide binding]; other site 326423008930 transglutaminase; Provisional; Region: tgl; PRK03187 326423008931 Nitronate monooxygenase; Region: NMO; pfam03060 326423008932 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 326423008933 FMN binding site [chemical binding]; other site 326423008934 substrate binding site [chemical binding]; other site 326423008935 putative catalytic residue [active] 326423008936 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 326423008937 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 326423008938 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 326423008939 Ca binding site [ion binding]; other site 326423008940 active site 326423008941 catalytic site [active] 326423008942 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 326423008943 Domain of unknown function DUF21; Region: DUF21; pfam01595 326423008944 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 326423008945 Transporter associated domain; Region: CorC_HlyC; smart01091 326423008946 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 326423008947 Ion channel; Region: Ion_trans_2; pfam07885 326423008948 TrkA-N domain; Region: TrkA_N; pfam02254 326423008949 YugN-like family; Region: YugN; pfam08868 326423008950 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 326423008951 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 326423008952 active site 326423008953 dimer interface [polypeptide binding]; other site 326423008954 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 326423008955 dimer interface [polypeptide binding]; other site 326423008956 active site 326423008957 Predicted flavoprotein [General function prediction only]; Region: COG0431 326423008958 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 326423008959 Isochorismatase family; Region: Isochorismatase; pfam00857 326423008960 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 326423008961 catalytic triad [active] 326423008962 dimer interface [polypeptide binding]; other site 326423008963 conserved cis-peptide bond; other site 326423008964 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 326423008965 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 326423008966 dimer interface [polypeptide binding]; other site 326423008967 active site 326423008968 metal binding site [ion binding]; metal-binding site 326423008969 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 326423008970 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 326423008971 dimer interface [polypeptide binding]; other site 326423008972 active site 326423008973 metal binding site [ion binding]; metal-binding site 326423008974 Uncharacterized conserved protein [Function unknown]; Region: COG2155 326423008975 general stress protein 13; Validated; Region: PRK08059 326423008976 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 326423008977 RNA binding site [nucleotide binding]; other site 326423008978 hypothetical protein; Validated; Region: PRK07682 326423008979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326423008980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423008981 homodimer interface [polypeptide binding]; other site 326423008982 catalytic residue [active] 326423008983 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 326423008984 AsnC family; Region: AsnC_trans_reg; pfam01037 326423008985 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326423008986 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 326423008987 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 326423008988 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 326423008989 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326423008990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423008991 homodimer interface [polypeptide binding]; other site 326423008992 catalytic residue [active] 326423008993 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423008994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423008995 dimer interface [polypeptide binding]; other site 326423008996 phosphorylation site [posttranslational modification] 326423008997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423008998 ATP binding site [chemical binding]; other site 326423008999 Mg2+ binding site [ion binding]; other site 326423009000 G-X-G motif; other site 326423009001 Kinase associated protein B; Region: KapB; pfam08810 326423009002 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 326423009003 active site 326423009004 catalytic site [active] 326423009005 substrate binding site [chemical binding]; other site 326423009006 sugar efflux transporter; Region: 2A0120; TIGR00899 326423009007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423009008 putative substrate translocation pore; other site 326423009009 Transglycosylase; Region: Transgly; pfam00912 326423009010 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 326423009011 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 326423009012 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 326423009013 sensory histidine kinase DcuS; Provisional; Region: PRK11086 326423009014 PAS domain; Region: PAS; smart00091 326423009015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423009016 ATP binding site [chemical binding]; other site 326423009017 Mg2+ binding site [ion binding]; other site 326423009018 G-X-G motif; other site 326423009019 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 326423009020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423009021 active site 326423009022 phosphorylation site [posttranslational modification] 326423009023 intermolecular recognition site; other site 326423009024 dimerization interface [polypeptide binding]; other site 326423009025 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 326423009026 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 326423009027 ligand binding site [chemical binding]; other site 326423009028 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 326423009029 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 326423009030 Walker A/P-loop; other site 326423009031 ATP binding site [chemical binding]; other site 326423009032 Q-loop/lid; other site 326423009033 ABC transporter signature motif; other site 326423009034 Walker B; other site 326423009035 D-loop; other site 326423009036 H-loop/switch region; other site 326423009037 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 326423009038 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 326423009039 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 326423009040 TM-ABC transporter signature motif; other site 326423009041 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 326423009042 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 326423009043 TM-ABC transporter signature motif; other site 326423009044 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 326423009045 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 326423009046 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 326423009047 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 326423009048 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 326423009049 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 326423009050 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 326423009051 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 326423009052 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 326423009053 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 326423009054 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 326423009055 CoenzymeA binding site [chemical binding]; other site 326423009056 subunit interaction site [polypeptide binding]; other site 326423009057 PHB binding site; other site 326423009058 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326423009059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423009060 active site 326423009061 phosphorylation site [posttranslational modification] 326423009062 intermolecular recognition site; other site 326423009063 dimerization interface [polypeptide binding]; other site 326423009064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326423009065 DNA binding residues [nucleotide binding] 326423009066 dimerization interface [polypeptide binding]; other site 326423009067 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 326423009068 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326423009069 Histidine kinase; Region: HisKA_3; pfam07730 326423009070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423009071 ATP binding site [chemical binding]; other site 326423009072 Mg2+ binding site [ion binding]; other site 326423009073 G-X-G motif; other site 326423009074 Bacillus competence pheromone ComX; Region: ComX; pfam05952 326423009075 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 326423009076 substrate binding pocket [chemical binding]; other site 326423009077 substrate-Mg2+ binding site; other site 326423009078 aspartate-rich region 1; other site 326423009079 DegQ (SacQ) family; Region: DegQ; pfam08181 326423009080 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 326423009081 EAL domain; Region: EAL; pfam00563 326423009082 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 326423009083 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 326423009084 active site 326423009085 Isochorismatase family; Region: Isochorismatase; pfam00857 326423009086 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 326423009087 catalytic triad [active] 326423009088 conserved cis-peptide bond; other site 326423009089 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 326423009090 YueH-like protein; Region: YueH; pfam14166 326423009091 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 326423009092 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 326423009093 Domain of unknown function DUF20; Region: UPF0118; pfam01594 326423009094 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 326423009095 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326423009096 Zn2+ binding site [ion binding]; other site 326423009097 Mg2+ binding site [ion binding]; other site 326423009098 short chain dehydrogenase; Provisional; Region: PRK06924 326423009099 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 326423009100 NADP binding site [chemical binding]; other site 326423009101 homodimer interface [polypeptide binding]; other site 326423009102 active site 326423009103 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 326423009104 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 326423009105 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 326423009106 IncA protein; Region: IncA; pfam04156 326423009107 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 326423009108 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 326423009109 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 326423009110 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326423009111 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326423009112 Domain of unknown function DUF87; Region: DUF87; pfam01935 326423009113 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 326423009114 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 326423009115 Uncharacterized small protein [Function unknown]; Region: COG5417 326423009116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 326423009117 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 326423009118 CodY GAF-like domain; Region: CodY; pfam06018 326423009119 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 326423009120 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 326423009121 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 326423009122 hexamer interface [polypeptide binding]; other site 326423009123 ligand binding site [chemical binding]; other site 326423009124 putative active site [active] 326423009125 NAD(P) binding site [chemical binding]; other site 326423009126 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 326423009127 MbtH-like protein; Region: MbtH; cl01279 326423009128 Condensation domain; Region: Condensation; pfam00668 326423009129 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 326423009130 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 326423009131 acyl-activating enzyme (AAE) consensus motif; other site 326423009132 AMP binding site [chemical binding]; other site 326423009133 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423009134 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 326423009135 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 326423009136 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 326423009137 acyl-activating enzyme (AAE) consensus motif; other site 326423009138 AMP binding site [chemical binding]; other site 326423009139 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326423009140 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 326423009141 hydrophobic substrate binding pocket; other site 326423009142 Isochorismatase family; Region: Isochorismatase; pfam00857 326423009143 active site 326423009144 conserved cis-peptide bond; other site 326423009145 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 326423009146 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 326423009147 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 326423009148 acyl-activating enzyme (AAE) consensus motif; other site 326423009149 active site 326423009150 AMP binding site [chemical binding]; other site 326423009151 substrate binding site [chemical binding]; other site 326423009152 isochorismate synthase DhbC; Validated; Region: PRK06923 326423009153 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 326423009154 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 326423009155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326423009156 NAD(P) binding site [chemical binding]; other site 326423009157 active site 326423009158 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 326423009159 Putative esterase; Region: Esterase; pfam00756 326423009160 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 326423009161 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 326423009162 Moco binding site; other site 326423009163 metal coordination site [ion binding]; other site 326423009164 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 326423009165 Predicted permease [General function prediction only]; Region: COG2056 326423009166 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 326423009167 multifunctional aminopeptidase A; Provisional; Region: PRK00913 326423009168 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 326423009169 interface (dimer of trimers) [polypeptide binding]; other site 326423009170 Substrate-binding/catalytic site; other site 326423009171 Zn-binding sites [ion binding]; other site 326423009172 Divergent PAP2 family; Region: DUF212; pfam02681 326423009173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 326423009174 Putative membrane protein; Region: YuiB; pfam14068 326423009175 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 326423009176 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 326423009177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326423009178 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 326423009179 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326423009180 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326423009181 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 326423009182 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 326423009183 active site 326423009184 Integral membrane protein DUF95; Region: DUF95; pfam01944 326423009185 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326423009186 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 326423009187 Walker A/P-loop; other site 326423009188 ATP binding site [chemical binding]; other site 326423009189 Q-loop/lid; other site 326423009190 ABC transporter signature motif; other site 326423009191 Walker B; other site 326423009192 D-loop; other site 326423009193 H-loop/switch region; other site 326423009194 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326423009195 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326423009196 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 326423009197 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 326423009198 putative NAD(P) binding site [chemical binding]; other site 326423009199 active site 326423009200 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 326423009201 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 326423009202 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 326423009203 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 326423009204 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 326423009205 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 326423009206 Nucleoside recognition; Region: Gate; pfam07670 326423009207 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 326423009208 hypothetical protein; Provisional; Region: PRK13669 326423009209 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 326423009210 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326423009211 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 326423009212 NifU-like domain; Region: NifU; pfam01106 326423009213 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 326423009214 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 326423009215 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 326423009216 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 326423009217 homoserine kinase; Provisional; Region: PRK01212 326423009218 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 326423009219 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 326423009220 threonine synthase; Reviewed; Region: PRK06721 326423009221 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 326423009222 homodimer interface [polypeptide binding]; other site 326423009223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423009224 catalytic residue [active] 326423009225 homoserine dehydrogenase; Provisional; Region: PRK06349 326423009226 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 326423009227 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 326423009228 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 326423009229 spore coat protein YutH; Region: spore_yutH; TIGR02905 326423009230 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 326423009231 tetramer interfaces [polypeptide binding]; other site 326423009232 binuclear metal-binding site [ion binding]; other site 326423009233 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 326423009234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423009235 active site 326423009236 motif I; other site 326423009237 motif II; other site 326423009238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423009239 Uncharacterized conserved protein [Function unknown]; Region: COG2445 326423009240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 326423009241 lipoyl synthase; Provisional; Region: PRK05481 326423009242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326423009243 FeS/SAM binding site; other site 326423009244 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 326423009245 Peptidase family M23; Region: Peptidase_M23; pfam01551 326423009246 sporulation protein YunB; Region: spo_yunB; TIGR02832 326423009247 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 326423009248 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 326423009249 active site 326423009250 metal binding site [ion binding]; metal-binding site 326423009251 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 326423009252 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 326423009253 Uncharacterized conserved protein [Function unknown]; Region: COG1801 326423009254 allantoinase; Provisional; Region: PRK06189 326423009255 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 326423009256 active site 326423009257 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 326423009258 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 326423009259 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 326423009260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423009261 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423009262 putative substrate translocation pore; other site 326423009263 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 326423009264 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326423009265 catalytic residue [active] 326423009266 allantoate amidohydrolase; Reviewed; Region: PRK09290 326423009267 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 326423009268 active site 326423009269 metal binding site [ion binding]; metal-binding site 326423009270 dimer interface [polypeptide binding]; other site 326423009271 Endonuclease I; Region: Endonuclease_1; pfam04231 326423009272 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 326423009273 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 326423009274 Walker A/P-loop; other site 326423009275 ATP binding site [chemical binding]; other site 326423009276 Q-loop/lid; other site 326423009277 ABC transporter signature motif; other site 326423009278 Walker B; other site 326423009279 D-loop; other site 326423009280 H-loop/switch region; other site 326423009281 TOBE domain; Region: TOBE_2; pfam08402 326423009282 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 326423009283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423009284 DNA-binding site [nucleotide binding]; DNA binding site 326423009285 UTRA domain; Region: UTRA; pfam07702 326423009286 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326423009287 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 326423009288 substrate binding site [chemical binding]; other site 326423009289 ATP binding site [chemical binding]; other site 326423009290 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326423009291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423009292 dimer interface [polypeptide binding]; other site 326423009293 conserved gate region; other site 326423009294 putative PBP binding loops; other site 326423009295 ABC-ATPase subunit interface; other site 326423009296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423009297 dimer interface [polypeptide binding]; other site 326423009298 conserved gate region; other site 326423009299 putative PBP binding loops; other site 326423009300 ABC-ATPase subunit interface; other site 326423009301 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326423009302 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326423009303 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 326423009304 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 326423009305 putative active site [active] 326423009306 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 326423009307 dimer interface [polypeptide binding]; other site 326423009308 active site 326423009309 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 326423009310 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326423009311 DNA binding residues [nucleotide binding] 326423009312 dimer interface [polypeptide binding]; other site 326423009313 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 326423009314 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 326423009315 GIY-YIG motif/motif A; other site 326423009316 active site 326423009317 catalytic site [active] 326423009318 putative DNA binding site [nucleotide binding]; other site 326423009319 metal binding site [ion binding]; metal-binding site 326423009320 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 326423009321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423009322 S-adenosylmethionine binding site [chemical binding]; other site 326423009323 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 326423009324 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 326423009325 chitosan binding site [chemical binding]; other site 326423009326 catalytic residues [active] 326423009327 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 326423009328 FeS assembly protein SufB; Region: sufB; TIGR01980 326423009329 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 326423009330 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 326423009331 trimerization site [polypeptide binding]; other site 326423009332 active site 326423009333 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 326423009334 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 326423009335 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326423009336 catalytic residue [active] 326423009337 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 326423009338 FeS assembly protein SufD; Region: sufD; TIGR01981 326423009339 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 326423009340 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 326423009341 Walker A/P-loop; other site 326423009342 ATP binding site [chemical binding]; other site 326423009343 Q-loop/lid; other site 326423009344 ABC transporter signature motif; other site 326423009345 Walker B; other site 326423009346 D-loop; other site 326423009347 H-loop/switch region; other site 326423009348 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 326423009349 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 326423009350 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 326423009351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423009352 dimer interface [polypeptide binding]; other site 326423009353 conserved gate region; other site 326423009354 ABC-ATPase subunit interface; other site 326423009355 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 326423009356 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 326423009357 Walker A/P-loop; other site 326423009358 ATP binding site [chemical binding]; other site 326423009359 Q-loop/lid; other site 326423009360 ABC transporter signature motif; other site 326423009361 Walker B; other site 326423009362 D-loop; other site 326423009363 H-loop/switch region; other site 326423009364 NIL domain; Region: NIL; pfam09383 326423009365 SCP-2 sterol transfer family; Region: SCP2; pfam02036 326423009366 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 326423009367 catalytic residues [active] 326423009368 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 326423009369 putative active site [active] 326423009370 putative metal binding site [ion binding]; other site 326423009371 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 326423009372 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 326423009373 lipoyl attachment site [posttranslational modification]; other site 326423009374 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 326423009375 ArsC family; Region: ArsC; pfam03960 326423009376 putative ArsC-like catalytic residues; other site 326423009377 putative TRX-like catalytic residues [active] 326423009378 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 326423009379 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 326423009380 active site 326423009381 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 326423009382 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 326423009383 dimer interface [polypeptide binding]; other site 326423009384 active site 326423009385 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 326423009386 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 326423009387 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 326423009388 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 326423009389 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 326423009390 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 326423009391 substrate binding site [chemical binding]; other site 326423009392 oxyanion hole (OAH) forming residues; other site 326423009393 trimer interface [polypeptide binding]; other site 326423009394 YuzL-like protein; Region: YuzL; pfam14115 326423009395 Proline dehydrogenase; Region: Pro_dh; cl03282 326423009396 Coat F domain; Region: Coat_F; pfam07875 326423009397 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423009398 MarR family; Region: MarR; pfam01047 326423009399 MarR family; Region: MarR_2; cl17246 326423009400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423009401 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423009402 putative substrate translocation pore; other site 326423009403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423009404 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 326423009405 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 326423009406 classical (c) SDRs; Region: SDR_c; cd05233 326423009407 NAD(P) binding site [chemical binding]; other site 326423009408 active site 326423009409 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423009410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423009411 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 326423009412 dimerization interface [polypeptide binding]; other site 326423009413 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423009414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423009415 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326423009416 dimerization interface [polypeptide binding]; other site 326423009417 acetoacetate decarboxylase; Provisional; Region: PRK02265 326423009418 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 326423009419 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 326423009420 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 326423009421 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 326423009422 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 326423009423 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 326423009424 Walker A/P-loop; other site 326423009425 ATP binding site [chemical binding]; other site 326423009426 Q-loop/lid; other site 326423009427 ABC transporter signature motif; other site 326423009428 Walker B; other site 326423009429 D-loop; other site 326423009430 H-loop/switch region; other site 326423009431 YusW-like protein; Region: YusW; pfam14039 326423009432 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 326423009433 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 326423009434 active site 326423009435 Zn binding site [ion binding]; other site 326423009436 short chain dehydrogenase; Provisional; Region: PRK06914 326423009437 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 326423009438 NADP binding site [chemical binding]; other site 326423009439 active site 326423009440 steroid binding site; other site 326423009441 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 326423009442 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 326423009443 dimerization interface [polypeptide binding]; other site 326423009444 DPS ferroxidase diiron center [ion binding]; other site 326423009445 ion pore; other site 326423009446 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 326423009447 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 326423009448 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 326423009449 protein binding site [polypeptide binding]; other site 326423009450 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423009451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423009452 active site 326423009453 phosphorylation site [posttranslational modification] 326423009454 intermolecular recognition site; other site 326423009455 dimerization interface [polypeptide binding]; other site 326423009456 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423009457 DNA binding site [nucleotide binding] 326423009458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423009459 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326423009460 dimerization interface [polypeptide binding]; other site 326423009461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423009462 dimer interface [polypeptide binding]; other site 326423009463 phosphorylation site [posttranslational modification] 326423009464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423009465 ATP binding site [chemical binding]; other site 326423009466 Mg2+ binding site [ion binding]; other site 326423009467 G-X-G motif; other site 326423009468 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423009469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423009470 fumarate hydratase; Reviewed; Region: fumC; PRK00485 326423009471 Class II fumarases; Region: Fumarase_classII; cd01362 326423009472 active site 326423009473 tetramer interface [polypeptide binding]; other site 326423009474 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 326423009475 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 326423009476 Spore germination protein; Region: Spore_permease; pfam03845 326423009477 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 326423009478 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 326423009479 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326423009480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423009481 active site 326423009482 phosphorylation site [posttranslational modification] 326423009483 intermolecular recognition site; other site 326423009484 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326423009485 DNA binding residues [nucleotide binding] 326423009486 dimerization interface [polypeptide binding]; other site 326423009487 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326423009488 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326423009489 dimerization interface [polypeptide binding]; other site 326423009490 Histidine kinase; Region: HisKA_3; pfam07730 326423009491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423009492 ATP binding site [chemical binding]; other site 326423009493 Mg2+ binding site [ion binding]; other site 326423009494 G-X-G motif; other site 326423009495 Predicted membrane protein [Function unknown]; Region: COG4758 326423009496 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 326423009497 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 326423009498 Uncharacterized conserved protein [Function unknown]; Region: COG3595 326423009499 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 326423009500 PspA/IM30 family; Region: PspA_IM30; pfam04012 326423009501 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 326423009502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423009503 H+ Antiporter protein; Region: 2A0121; TIGR00900 326423009504 putative substrate translocation pore; other site 326423009505 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 326423009506 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 326423009507 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 326423009508 Walker A/P-loop; other site 326423009509 ATP binding site [chemical binding]; other site 326423009510 Q-loop/lid; other site 326423009511 ABC transporter signature motif; other site 326423009512 Walker B; other site 326423009513 D-loop; other site 326423009514 H-loop/switch region; other site 326423009515 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 326423009516 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 326423009517 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 326423009518 ABC-ATPase subunit interface; other site 326423009519 dimer interface [polypeptide binding]; other site 326423009520 putative PBP binding regions; other site 326423009521 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 326423009522 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 326423009523 putative binding site residues; other site 326423009524 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 326423009525 classical (c) SDRs; Region: SDR_c; cd05233 326423009526 NAD(P) binding site [chemical binding]; other site 326423009527 active site 326423009528 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 326423009529 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423009530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423009531 dimer interface [polypeptide binding]; other site 326423009532 phosphorylation site [posttranslational modification] 326423009533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423009534 ATP binding site [chemical binding]; other site 326423009535 Mg2+ binding site [ion binding]; other site 326423009536 G-X-G motif; other site 326423009537 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423009538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423009539 active site 326423009540 phosphorylation site [posttranslational modification] 326423009541 intermolecular recognition site; other site 326423009542 dimerization interface [polypeptide binding]; other site 326423009543 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423009544 DNA binding site [nucleotide binding] 326423009545 hypothetical protein; Provisional; Region: PRK14082 326423009546 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 326423009547 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326423009548 DNA binding residues [nucleotide binding] 326423009549 YvrJ protein family; Region: YvrJ; pfam12841 326423009550 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 326423009551 Cupin; Region: Cupin_1; smart00835 326423009552 Cupin; Region: Cupin_1; smart00835 326423009553 Regulatory protein YrvL; Region: YrvL; pfam14184 326423009554 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 326423009555 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 326423009556 Walker A/P-loop; other site 326423009557 ATP binding site [chemical binding]; other site 326423009558 Q-loop/lid; other site 326423009559 ABC transporter signature motif; other site 326423009560 Walker B; other site 326423009561 D-loop; other site 326423009562 H-loop/switch region; other site 326423009563 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 326423009564 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 326423009565 ABC-ATPase subunit interface; other site 326423009566 dimer interface [polypeptide binding]; other site 326423009567 putative PBP binding regions; other site 326423009568 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 326423009569 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 326423009570 ABC-ATPase subunit interface; other site 326423009571 dimer interface [polypeptide binding]; other site 326423009572 putative PBP binding regions; other site 326423009573 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 326423009574 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 326423009575 putative ligand binding residues [chemical binding]; other site 326423009576 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 326423009577 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; cl09798 326423009578 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 326423009579 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 326423009580 Sulfatase; Region: Sulfatase; pfam00884 326423009581 DNA binding domain, excisionase family; Region: excise; TIGR01764 326423009582 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 326423009583 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 326423009584 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 326423009585 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 326423009586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423009587 dimer interface [polypeptide binding]; other site 326423009588 conserved gate region; other site 326423009589 putative PBP binding loops; other site 326423009590 ABC-ATPase subunit interface; other site 326423009591 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326423009592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423009593 active site 326423009594 phosphorylation site [posttranslational modification] 326423009595 intermolecular recognition site; other site 326423009596 dimerization interface [polypeptide binding]; other site 326423009597 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326423009598 DNA binding residues [nucleotide binding] 326423009599 dimerization interface [polypeptide binding]; other site 326423009600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326423009601 Histidine kinase; Region: HisKA_3; pfam07730 326423009602 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326423009603 Mg2+ binding site [ion binding]; other site 326423009604 G-X-G motif; other site 326423009605 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326423009606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326423009607 Walker A/P-loop; other site 326423009608 ATP binding site [chemical binding]; other site 326423009609 Q-loop/lid; other site 326423009610 ABC transporter signature motif; other site 326423009611 Walker B; other site 326423009612 D-loop; other site 326423009613 H-loop/switch region; other site 326423009614 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 326423009615 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 326423009616 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 326423009617 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 326423009618 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 326423009619 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326423009620 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326423009621 active site 326423009622 catalytic tetrad [active] 326423009623 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 326423009624 sulfite reductase subunit beta; Provisional; Region: PRK13504 326423009625 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 326423009626 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 326423009627 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 326423009628 Flavodoxin; Region: Flavodoxin_1; pfam00258 326423009629 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 326423009630 FAD binding pocket [chemical binding]; other site 326423009631 FAD binding motif [chemical binding]; other site 326423009632 catalytic residues [active] 326423009633 NAD binding pocket [chemical binding]; other site 326423009634 phosphate binding motif [ion binding]; other site 326423009635 beta-alpha-beta structure motif; other site 326423009636 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 326423009637 Family description; Region: UvrD_C_2; pfam13538 326423009638 Predicted membrane protein [Function unknown]; Region: COG2860 326423009639 UPF0126 domain; Region: UPF0126; pfam03458 326423009640 UPF0126 domain; Region: UPF0126; pfam03458 326423009641 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 326423009642 active site 326423009643 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 326423009644 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 326423009645 Thioredoxin; Region: Thioredoxin_4; pfam13462 326423009646 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 326423009647 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 326423009648 metal-binding site [ion binding] 326423009649 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326423009650 Soluble P-type ATPase [General function prediction only]; Region: COG4087 326423009651 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 326423009652 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 326423009653 metal-binding site [ion binding] 326423009654 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 326423009655 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 326423009656 metal-binding site [ion binding] 326423009657 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326423009658 Soluble P-type ATPase [General function prediction only]; Region: COG4087 326423009659 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 326423009660 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 326423009661 metal-binding site [ion binding] 326423009662 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 326423009663 putative homodimer interface [polypeptide binding]; other site 326423009664 putative homotetramer interface [polypeptide binding]; other site 326423009665 putative allosteric switch controlling residues; other site 326423009666 putative metal binding site [ion binding]; other site 326423009667 putative homodimer-homodimer interface [polypeptide binding]; other site 326423009668 putative oxidoreductase; Provisional; Region: PRK11579 326423009669 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 326423009670 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 326423009671 azoreductase; Reviewed; Region: PRK00170 326423009672 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 326423009673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326423009674 salt bridge; other site 326423009675 non-specific DNA binding site [nucleotide binding]; other site 326423009676 sequence-specific DNA binding site [nucleotide binding]; other site 326423009677 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 326423009678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423009679 putative substrate translocation pore; other site 326423009680 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 326423009681 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326423009682 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 326423009683 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 326423009684 active site 326423009685 non-prolyl cis peptide bond; other site 326423009686 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 326423009687 catalytic residues [active] 326423009688 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 326423009689 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 326423009690 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326423009691 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326423009692 Walker A/P-loop; other site 326423009693 ATP binding site [chemical binding]; other site 326423009694 Q-loop/lid; other site 326423009695 ABC transporter signature motif; other site 326423009696 Walker B; other site 326423009697 D-loop; other site 326423009698 H-loop/switch region; other site 326423009699 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 326423009700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423009701 dimer interface [polypeptide binding]; other site 326423009702 conserved gate region; other site 326423009703 putative PBP binding loops; other site 326423009704 ABC-ATPase subunit interface; other site 326423009705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423009706 dimer interface [polypeptide binding]; other site 326423009707 conserved gate region; other site 326423009708 putative PBP binding loops; other site 326423009709 ABC-ATPase subunit interface; other site 326423009710 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326423009711 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326423009712 substrate binding pocket [chemical binding]; other site 326423009713 membrane-bound complex binding site; other site 326423009714 hinge residues; other site 326423009715 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 326423009716 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326423009717 substrate binding pocket [chemical binding]; other site 326423009718 membrane-bound complex binding site; other site 326423009719 hinge residues; other site 326423009720 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 326423009721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423009722 Coenzyme A binding pocket [chemical binding]; other site 326423009723 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 326423009724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423009725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423009726 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326423009727 dimerization interface [polypeptide binding]; other site 326423009728 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 326423009729 classical (c) SDRs; Region: SDR_c; cd05233 326423009730 NAD(P) binding site [chemical binding]; other site 326423009731 active site 326423009732 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 326423009733 RNAase interaction site [polypeptide binding]; other site 326423009734 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 326423009735 SmpB-tmRNA interface; other site 326423009736 ribonuclease R; Region: RNase_R; TIGR02063 326423009737 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 326423009738 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 326423009739 RNB domain; Region: RNB; pfam00773 326423009740 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 326423009741 RNA binding site [nucleotide binding]; other site 326423009742 Esterase/lipase [General function prediction only]; Region: COG1647 326423009743 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326423009744 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 326423009745 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326423009746 salt bridge; other site 326423009747 non-specific DNA binding site [nucleotide binding]; other site 326423009748 sequence-specific DNA binding site [nucleotide binding]; other site 326423009749 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326423009750 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326423009751 non-specific DNA binding site [nucleotide binding]; other site 326423009752 salt bridge; other site 326423009753 sequence-specific DNA binding site [nucleotide binding]; other site 326423009754 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326423009755 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326423009756 non-specific DNA binding site [nucleotide binding]; other site 326423009757 salt bridge; other site 326423009758 sequence-specific DNA binding site [nucleotide binding]; other site 326423009759 Predicted transcriptional regulators [Transcription]; Region: COG1733 326423009760 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326423009761 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423009762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423009763 dimer interface [polypeptide binding]; other site 326423009764 phosphorylation site [posttranslational modification] 326423009765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423009766 ATP binding site [chemical binding]; other site 326423009767 Mg2+ binding site [ion binding]; other site 326423009768 G-X-G motif; other site 326423009769 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423009770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423009771 active site 326423009772 phosphorylation site [posttranslational modification] 326423009773 intermolecular recognition site; other site 326423009774 dimerization interface [polypeptide binding]; other site 326423009775 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423009776 DNA binding site [nucleotide binding] 326423009777 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 326423009778 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 326423009779 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 326423009780 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 326423009781 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 326423009782 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 326423009783 Walker A/P-loop; other site 326423009784 ATP binding site [chemical binding]; other site 326423009785 Q-loop/lid; other site 326423009786 ABC transporter signature motif; other site 326423009787 Walker B; other site 326423009788 D-loop; other site 326423009789 H-loop/switch region; other site 326423009790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423009791 dimer interface [polypeptide binding]; other site 326423009792 conserved gate region; other site 326423009793 putative PBP binding loops; other site 326423009794 ABC-ATPase subunit interface; other site 326423009795 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 326423009796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423009797 dimer interface [polypeptide binding]; other site 326423009798 conserved gate region; other site 326423009799 putative PBP binding loops; other site 326423009800 ABC-ATPase subunit interface; other site 326423009801 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 326423009802 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 326423009803 Walker A/P-loop; other site 326423009804 ATP binding site [chemical binding]; other site 326423009805 Q-loop/lid; other site 326423009806 ABC transporter signature motif; other site 326423009807 Walker B; other site 326423009808 D-loop; other site 326423009809 H-loop/switch region; other site 326423009810 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 326423009811 Predicted transcriptional regulators [Transcription]; Region: COG1510 326423009812 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326423009813 putative DNA binding site [nucleotide binding]; other site 326423009814 putative Zn2+ binding site [ion binding]; other site 326423009815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423009816 dimer interface [polypeptide binding]; other site 326423009817 conserved gate region; other site 326423009818 putative PBP binding loops; other site 326423009819 ABC-ATPase subunit interface; other site 326423009820 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 326423009821 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 326423009822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326423009823 dimer interface [polypeptide binding]; other site 326423009824 conserved gate region; other site 326423009825 putative PBP binding loops; other site 326423009826 ABC-ATPase subunit interface; other site 326423009827 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 326423009828 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 326423009829 Walker A/P-loop; other site 326423009830 ATP binding site [chemical binding]; other site 326423009831 Q-loop/lid; other site 326423009832 ABC transporter signature motif; other site 326423009833 Walker B; other site 326423009834 D-loop; other site 326423009835 H-loop/switch region; other site 326423009836 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 326423009837 Predicted transcriptional regulators [Transcription]; Region: COG1510 326423009838 MarR family; Region: MarR_2; pfam12802 326423009839 membrane protein, MarC family; Region: TIGR00427 326423009840 Predicted membrane protein [Function unknown]; Region: COG4640 326423009841 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 326423009842 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423009843 Coenzyme A binding pocket [chemical binding]; other site 326423009844 H+ Antiporter protein; Region: 2A0121; TIGR00900 326423009845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423009846 putative substrate translocation pore; other site 326423009847 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 326423009848 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 326423009849 WbqC-like protein family; Region: WbqC; pfam08889 326423009850 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 326423009851 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326423009852 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326423009853 catalytic residue [active] 326423009854 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 326423009855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326423009856 NAD(P) binding site [chemical binding]; other site 326423009857 active site 326423009858 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 326423009859 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 326423009860 inhibitor-cofactor binding pocket; inhibition site 326423009861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423009862 catalytic residue [active] 326423009863 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 326423009864 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 326423009865 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 326423009866 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 326423009867 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 326423009868 putative integrin binding motif; other site 326423009869 PA/protease domain interface [polypeptide binding]; other site 326423009870 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 326423009871 Peptidase family M28; Region: Peptidase_M28; pfam04389 326423009872 metal binding site [ion binding]; metal-binding site 326423009873 enolase; Provisional; Region: eno; PRK00077 326423009874 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 326423009875 dimer interface [polypeptide binding]; other site 326423009876 metal binding site [ion binding]; metal-binding site 326423009877 substrate binding pocket [chemical binding]; other site 326423009878 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 326423009879 phosphoglyceromutase; Provisional; Region: PRK05434 326423009880 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 326423009881 triosephosphate isomerase; Provisional; Region: PRK14565 326423009882 substrate binding site [chemical binding]; other site 326423009883 dimer interface [polypeptide binding]; other site 326423009884 catalytic triad [active] 326423009885 Phosphoglycerate kinase; Region: PGK; pfam00162 326423009886 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 326423009887 substrate binding site [chemical binding]; other site 326423009888 hinge regions; other site 326423009889 ADP binding site [chemical binding]; other site 326423009890 catalytic site [active] 326423009891 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 326423009892 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 326423009893 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 326423009894 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 326423009895 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 326423009896 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 326423009897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423009898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423009899 DNA-binding site [nucleotide binding]; DNA binding site 326423009900 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326423009901 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 326423009902 putative dimerization interface [polypeptide binding]; other site 326423009903 putative ligand binding site [chemical binding]; other site 326423009904 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 326423009905 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326423009906 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 326423009907 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423009908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423009909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326423009910 dimerization interface [polypeptide binding]; other site 326423009911 EamA-like transporter family; Region: EamA; pfam00892 326423009912 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 326423009913 EamA-like transporter family; Region: EamA; pfam00892 326423009914 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 326423009915 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 326423009916 active site 326423009917 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326423009918 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326423009919 DNA binding site [nucleotide binding] 326423009920 domain linker motif; other site 326423009921 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 326423009922 putative ligand binding site [chemical binding]; other site 326423009923 putative dimerization interface [polypeptide binding]; other site 326423009924 Predicted membrane protein [Function unknown]; Region: COG2364 326423009925 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423009926 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326423009927 active site 326423009928 motif I; other site 326423009929 motif II; other site 326423009930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423009931 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 326423009932 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 326423009933 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 326423009934 putative active site [active] 326423009935 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 326423009936 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 326423009937 N- and C-terminal domain interface [polypeptide binding]; other site 326423009938 active site 326423009939 catalytic site [active] 326423009940 metal binding site [ion binding]; metal-binding site 326423009941 carbohydrate binding site [chemical binding]; other site 326423009942 ATP binding site [chemical binding]; other site 326423009943 fructuronate transporter; Provisional; Region: PRK10034; cl15264 326423009944 GntP family permease; Region: GntP_permease; pfam02447 326423009945 Uncharacterized conserved protein [Function unknown]; Region: COG1556 326423009946 iron-sulfur cluster-binding protein; Region: TIGR00273 326423009947 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 326423009948 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 326423009949 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 326423009950 Cysteine-rich domain; Region: CCG; pfam02754 326423009951 Cysteine-rich domain; Region: CCG; pfam02754 326423009952 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 326423009953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326423009954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423009955 homodimer interface [polypeptide binding]; other site 326423009956 catalytic residue [active] 326423009957 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326423009958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423009959 DNA-binding site [nucleotide binding]; DNA binding site 326423009960 FCD domain; Region: FCD; pfam07729 326423009961 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 326423009962 L-lactate permease; Region: Lactate_perm; pfam02652 326423009963 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 326423009964 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 326423009965 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 326423009966 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 326423009967 YvfG protein; Region: YvfG; pfam09628 326423009968 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 326423009969 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 326423009970 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 326423009971 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 326423009972 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 326423009973 inhibitor-cofactor binding pocket; inhibition site 326423009974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423009975 catalytic residue [active] 326423009976 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 326423009977 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 326423009978 putative trimer interface [polypeptide binding]; other site 326423009979 putative CoA binding site [chemical binding]; other site 326423009980 Bacterial sugar transferase; Region: Bac_transf; pfam02397 326423009981 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 326423009982 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 326423009983 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326423009984 active site 326423009985 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 326423009986 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 326423009987 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 326423009988 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326423009989 active site 326423009990 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326423009991 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 326423009992 putative ADP-binding pocket [chemical binding]; other site 326423009993 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 326423009994 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 326423009995 active site 326423009996 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 326423009997 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326423009998 putative ADP-binding pocket [chemical binding]; other site 326423009999 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 326423010000 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 326423010001 NAD(P) binding site [chemical binding]; other site 326423010002 homodimer interface [polypeptide binding]; other site 326423010003 substrate binding site [chemical binding]; other site 326423010004 active site 326423010005 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 326423010006 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326423010007 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 326423010008 Chain length determinant protein; Region: Wzz; cl15801 326423010009 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326423010010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326423010011 non-specific DNA binding site [nucleotide binding]; other site 326423010012 salt bridge; other site 326423010013 sequence-specific DNA binding site [nucleotide binding]; other site 326423010014 Anti-repressor SinI; Region: SinI; pfam08671 326423010015 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 326423010016 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 326423010017 substrate binding pocket [chemical binding]; other site 326423010018 catalytic triad [active] 326423010019 RibD C-terminal domain; Region: RibD_C; cl17279 326423010020 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 326423010021 Predicted membrane protein [Function unknown]; Region: COG2364 326423010022 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423010023 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 326423010024 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423010025 Coenzyme A binding pocket [chemical binding]; other site 326423010026 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 326423010027 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 326423010028 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 326423010029 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 326423010030 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 326423010031 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 326423010032 substrate binding [chemical binding]; other site 326423010033 active site 326423010034 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 326423010035 galactoside permease; Reviewed; Region: lacY; PRK09528 326423010036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423010037 putative substrate translocation pore; other site 326423010038 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326423010039 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326423010040 DNA binding site [nucleotide binding] 326423010041 domain linker motif; other site 326423010042 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 326423010043 dimerization interface [polypeptide binding]; other site 326423010044 ligand binding site [chemical binding]; other site 326423010045 sodium binding site [ion binding]; other site 326423010046 Clp protease; Region: CLP_protease; pfam00574 326423010047 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 326423010048 oligomer interface [polypeptide binding]; other site 326423010049 active site residues [active] 326423010050 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423010051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423010052 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326423010053 dimerization interface [polypeptide binding]; other site 326423010054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 326423010055 benzoate transport; Region: 2A0115; TIGR00895 326423010056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423010057 putative substrate translocation pore; other site 326423010058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423010059 TIGR00730 family protein; Region: TIGR00730 326423010060 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 326423010061 metal binding site [ion binding]; metal-binding site 326423010062 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 326423010063 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 326423010064 Sulfate transporter family; Region: Sulfate_transp; pfam00916 326423010065 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 326423010066 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 326423010067 active site clefts [active] 326423010068 zinc binding site [ion binding]; other site 326423010069 dimer interface [polypeptide binding]; other site 326423010070 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 326423010071 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 326423010072 dimerization interface [polypeptide binding]; other site 326423010073 ligand binding site [chemical binding]; other site 326423010074 NADP binding site [chemical binding]; other site 326423010075 catalytic site [active] 326423010076 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 326423010077 active site 326423010078 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 326423010079 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 326423010080 dimerization domain swap beta strand [polypeptide binding]; other site 326423010081 regulatory protein interface [polypeptide binding]; other site 326423010082 active site 326423010083 regulatory phosphorylation site [posttranslational modification]; other site 326423010084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 326423010085 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 326423010086 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 326423010087 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 326423010088 phosphate binding site [ion binding]; other site 326423010089 putative substrate binding pocket [chemical binding]; other site 326423010090 dimer interface [polypeptide binding]; other site 326423010091 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 326423010092 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 326423010093 putative active site [active] 326423010094 nucleotide binding site [chemical binding]; other site 326423010095 nudix motif; other site 326423010096 putative metal binding site [ion binding]; other site 326423010097 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 326423010098 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326423010099 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326423010100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 326423010101 GDP/GTP exchange factor Sec2p; Region: Sec2p; pfam06428 326423010102 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326423010103 NlpC/P60 family; Region: NLPC_P60; pfam00877 326423010104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326423010105 binding surface 326423010106 Tetratricopeptide repeat; Region: TPR_16; pfam13432 326423010107 TPR motif; other site 326423010108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326423010109 TPR motif; other site 326423010110 binding surface 326423010111 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423010112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423010113 dimer interface [polypeptide binding]; other site 326423010114 phosphorylation site [posttranslational modification] 326423010115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423010116 ATP binding site [chemical binding]; other site 326423010117 Mg2+ binding site [ion binding]; other site 326423010118 G-X-G motif; other site 326423010119 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423010120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423010121 active site 326423010122 phosphorylation site [posttranslational modification] 326423010123 intermolecular recognition site; other site 326423010124 dimerization interface [polypeptide binding]; other site 326423010125 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423010126 DNA binding site [nucleotide binding] 326423010127 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326423010128 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326423010129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326423010130 Walker A/P-loop; other site 326423010131 ATP binding site [chemical binding]; other site 326423010132 Q-loop/lid; other site 326423010133 ABC transporter signature motif; other site 326423010134 Walker B; other site 326423010135 D-loop; other site 326423010136 H-loop/switch region; other site 326423010137 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 326423010138 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 326423010139 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 326423010140 metal binding site [ion binding]; metal-binding site 326423010141 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 326423010142 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 326423010143 substrate binding site [chemical binding]; other site 326423010144 glutamase interaction surface [polypeptide binding]; other site 326423010145 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 326423010146 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 326423010147 catalytic residues [active] 326423010148 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 326423010149 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 326423010150 putative active site [active] 326423010151 oxyanion strand; other site 326423010152 catalytic triad [active] 326423010153 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 326423010154 putative active site pocket [active] 326423010155 4-fold oligomerization interface [polypeptide binding]; other site 326423010156 metal binding residues [ion binding]; metal-binding site 326423010157 3-fold/trimer interface [polypeptide binding]; other site 326423010158 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 326423010159 histidinol dehydrogenase; Region: hisD; TIGR00069 326423010160 NAD binding site [chemical binding]; other site 326423010161 dimerization interface [polypeptide binding]; other site 326423010162 product binding site; other site 326423010163 substrate binding site [chemical binding]; other site 326423010164 zinc binding site [ion binding]; other site 326423010165 catalytic residues [active] 326423010166 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 326423010167 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 326423010168 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 326423010169 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 326423010170 dimer interface [polypeptide binding]; other site 326423010171 motif 1; other site 326423010172 active site 326423010173 motif 2; other site 326423010174 motif 3; other site 326423010175 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 326423010176 putative active site [active] 326423010177 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 326423010178 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 326423010179 trimer interface [polypeptide binding]; other site 326423010180 active site 326423010181 substrate binding site [chemical binding]; other site 326423010182 CoA binding site [chemical binding]; other site 326423010183 pyrophosphatase PpaX; Provisional; Region: PRK13288 326423010184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 326423010185 motif I; other site 326423010186 active site 326423010187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423010188 motif II; other site 326423010189 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 326423010190 HPr kinase/phosphorylase; Provisional; Region: PRK05428 326423010191 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 326423010192 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 326423010193 Hpr binding site; other site 326423010194 active site 326423010195 homohexamer subunit interaction site [polypeptide binding]; other site 326423010196 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 326423010197 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 326423010198 active site 326423010199 dimer interface [polypeptide binding]; other site 326423010200 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 326423010201 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 326423010202 active site 326423010203 trimer interface [polypeptide binding]; other site 326423010204 allosteric site; other site 326423010205 active site lid [active] 326423010206 hexamer (dimer of trimers) interface [polypeptide binding]; other site 326423010207 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 326423010208 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423010209 DNA-binding site [nucleotide binding]; DNA binding site 326423010210 UTRA domain; Region: UTRA; pfam07702 326423010211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423010212 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423010213 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 326423010214 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 326423010215 putative active site [active] 326423010216 putative metal binding site [ion binding]; other site 326423010217 Predicted membrane protein [Function unknown]; Region: COG1950 326423010218 PspC domain; Region: PspC; pfam04024 326423010219 Uncharacterized conserved protein [Function unknown]; Region: COG3595 326423010220 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 326423010221 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 326423010222 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 326423010223 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 326423010224 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 326423010225 excinuclease ABC subunit B; Provisional; Region: PRK05298 326423010226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326423010227 ATP binding site [chemical binding]; other site 326423010228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326423010229 nucleotide binding region [chemical binding]; other site 326423010230 ATP-binding site [chemical binding]; other site 326423010231 Ultra-violet resistance protein B; Region: UvrB; pfam12344 326423010232 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 326423010233 phosphoenolpyruvate synthase; Validated; Region: PRK06241 326423010234 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 326423010235 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 326423010236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423010237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423010238 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326423010239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423010240 putative substrate translocation pore; other site 326423010241 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 326423010242 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 326423010243 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 326423010244 C-terminal peptidase (prc); Region: prc; TIGR00225 326423010245 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 326423010246 protein binding site [polypeptide binding]; other site 326423010247 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 326423010248 Catalytic dyad [active] 326423010249 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 326423010250 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 326423010251 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 326423010252 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 326423010253 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 326423010254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326423010255 Walker A/P-loop; other site 326423010256 ATP binding site [chemical binding]; other site 326423010257 Q-loop/lid; other site 326423010258 ABC transporter signature motif; other site 326423010259 Walker B; other site 326423010260 D-loop; other site 326423010261 H-loop/switch region; other site 326423010262 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 326423010263 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 326423010264 Uncharacterized conserved protein [Function unknown]; Region: COG1284 326423010265 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423010266 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423010267 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 326423010268 peptide chain release factor 2; Provisional; Region: PRK06746 326423010269 This domain is found in peptide chain release factors; Region: PCRF; smart00937 326423010270 RF-1 domain; Region: RF-1; pfam00472 326423010271 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 326423010272 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 326423010273 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 326423010274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 326423010275 nucleotide binding region [chemical binding]; other site 326423010276 ATP-binding site [chemical binding]; other site 326423010277 SEC-C motif; Region: SEC-C; pfam02810 326423010278 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 326423010279 30S subunit binding site; other site 326423010280 Flagellar protein FliT; Region: FliT; pfam05400 326423010281 flagellar protein FliS; Validated; Region: fliS; PRK05685 326423010282 flagellar capping protein; Validated; Region: fliD; PRK07737 326423010283 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 326423010284 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 326423010285 flagellin; Provisional; Region: PRK12804 326423010286 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 326423010287 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 326423010288 carbon storage regulator; Provisional; Region: PRK01712 326423010289 flagellar assembly protein FliW; Provisional; Region: PRK13285 326423010290 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 326423010291 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 326423010292 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 326423010293 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 326423010294 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 326423010295 FlgN protein; Region: FlgN; pfam05130 326423010296 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 326423010297 flagellar operon protein TIGR03826; Region: YvyF 326423010298 comF family protein; Region: comF; TIGR00201 326423010299 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326423010300 active site 326423010301 Late competence development protein ComFB; Region: ComFB; pfam10719 326423010302 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 326423010303 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326423010304 ATP binding site [chemical binding]; other site 326423010305 putative Mg++ binding site [ion binding]; other site 326423010306 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326423010307 nucleotide binding region [chemical binding]; other site 326423010308 ATP-binding site [chemical binding]; other site 326423010309 EDD domain protein, DegV family; Region: DegV; TIGR00762 326423010310 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 326423010311 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326423010312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423010313 active site 326423010314 phosphorylation site [posttranslational modification] 326423010315 intermolecular recognition site; other site 326423010316 dimerization interface [polypeptide binding]; other site 326423010317 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326423010318 DNA binding residues [nucleotide binding] 326423010319 dimerization interface [polypeptide binding]; other site 326423010320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326423010321 Histidine kinase; Region: HisKA_3; pfam07730 326423010322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423010323 ATP binding site [chemical binding]; other site 326423010324 Mg2+ binding site [ion binding]; other site 326423010325 G-X-G motif; other site 326423010326 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 326423010327 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 326423010328 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 326423010329 Transcriptional regulator [Transcription]; Region: LytR; COG1316 326423010330 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 326423010331 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 326423010332 Mg++ binding site [ion binding]; other site 326423010333 putative catalytic motif [active] 326423010334 substrate binding site [chemical binding]; other site 326423010335 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 326423010336 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326423010337 putative homodimer interface [polypeptide binding]; other site 326423010338 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 326423010339 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326423010340 active site 326423010341 O-Antigen ligase; Region: Wzy_C; pfam04932 326423010342 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 326423010343 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 326423010344 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 326423010345 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 326423010346 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326423010347 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 326423010348 colanic acid exporter; Provisional; Region: PRK10459 326423010349 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 326423010350 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 326423010351 Bacterial sugar transferase; Region: Bac_transf; pfam02397 326423010352 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 326423010353 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 326423010354 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 326423010355 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 326423010356 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 326423010357 active site 326423010358 metal binding site [ion binding]; metal-binding site 326423010359 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 326423010360 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 326423010361 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 326423010362 Stage II sporulation protein; Region: SpoIID; pfam08486 326423010363 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 326423010364 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 326423010365 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 326423010366 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 326423010367 active site 326423010368 homodimer interface [polypeptide binding]; other site 326423010369 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 326423010370 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 326423010371 active site 326423010372 tetramer interface; other site 326423010373 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 326423010374 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 326423010375 Walker A/P-loop; other site 326423010376 ATP binding site [chemical binding]; other site 326423010377 Q-loop/lid; other site 326423010378 ABC transporter signature motif; other site 326423010379 Walker B; other site 326423010380 D-loop; other site 326423010381 H-loop/switch region; other site 326423010382 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 326423010383 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 326423010384 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 326423010385 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 326423010386 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326423010387 active site 326423010388 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 326423010389 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 326423010390 active site 326423010391 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 326423010392 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 326423010393 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 326423010394 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 326423010395 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 326423010396 Bacterial SH3 domain; Region: SH3_3; pfam08239 326423010397 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 326423010398 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 326423010399 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 326423010400 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 326423010401 Spore germination protein; Region: Spore_permease; pfam03845 326423010402 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 326423010403 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 326423010404 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 326423010405 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 326423010406 Probable Catalytic site; other site 326423010407 metal-binding site 326423010408 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326423010409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423010410 S-adenosylmethionine binding site [chemical binding]; other site 326423010411 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 326423010412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423010413 putative substrate translocation pore; other site 326423010414 Transcriptional regulator [Transcription]; Region: LytR; COG1316 326423010415 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423010416 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326423010417 active site 326423010418 motif I; other site 326423010419 motif II; other site 326423010420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423010421 Septum formation initiator; Region: DivIC; cl17659 326423010422 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 326423010423 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326423010424 NlpC/P60 family; Region: NLPC_P60; pfam00877 326423010425 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326423010426 NlpC/P60 family; Region: NLPC_P60; pfam00877 326423010427 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326423010428 NlpC/P60 family; Region: NLPC_P60; pfam00877 326423010429 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 326423010430 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 326423010431 putative active site [active] 326423010432 putative metal binding site [ion binding]; other site 326423010433 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 326423010434 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 326423010435 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326423010436 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 326423010437 Spore germination protein; Region: Spore_permease; cl17796 326423010438 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 326423010439 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 326423010440 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326423010441 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326423010442 DNA binding site [nucleotide binding] 326423010443 domain linker motif; other site 326423010444 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326423010445 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326423010446 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 326423010447 substrate binding site [chemical binding]; other site 326423010448 dimer interface [polypeptide binding]; other site 326423010449 ATP binding site [chemical binding]; other site 326423010450 D-ribose pyranase; Provisional; Region: PRK11797 326423010451 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 326423010452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326423010453 Walker A/P-loop; other site 326423010454 ATP binding site [chemical binding]; other site 326423010455 Q-loop/lid; other site 326423010456 ABC transporter signature motif; other site 326423010457 Walker B; other site 326423010458 D-loop; other site 326423010459 H-loop/switch region; other site 326423010460 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 326423010461 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 326423010462 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 326423010463 TM-ABC transporter signature motif; other site 326423010464 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 326423010465 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 326423010466 ligand binding site [chemical binding]; other site 326423010467 dimerization interface [polypeptide binding]; other site 326423010468 Bacterial SH3 domain homologues; Region: SH3b; smart00287 326423010469 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 326423010470 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 326423010471 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 326423010472 acetolactate synthase; Reviewed; Region: PRK08617 326423010473 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 326423010474 PYR/PP interface [polypeptide binding]; other site 326423010475 dimer interface [polypeptide binding]; other site 326423010476 TPP binding site [chemical binding]; other site 326423010477 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 326423010478 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 326423010479 TPP-binding site [chemical binding]; other site 326423010480 dimer interface [polypeptide binding]; other site 326423010481 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 326423010482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423010483 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 326423010484 putative dimerization interface [polypeptide binding]; other site 326423010485 putative substrate binding pocket [chemical binding]; other site 326423010486 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 326423010487 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 326423010488 transmembrane helices; other site 326423010489 CotH protein; Region: CotH; pfam08757 326423010490 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 326423010491 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 326423010492 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 326423010493 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 326423010494 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326423010495 putative DNA binding site [nucleotide binding]; other site 326423010496 putative Zn2+ binding site [ion binding]; other site 326423010497 AsnC family; Region: AsnC_trans_reg; pfam01037 326423010498 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 326423010499 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 326423010500 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 326423010501 Active_site [active] 326423010502 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 326423010503 GAD-like domain; Region: GAD-like; pfam08887 326423010504 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 326423010505 HTH-like domain; Region: HTH_21; pfam13276 326423010506 Integrase core domain; Region: rve; pfam00665 326423010507 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 326423010508 LXG domain of WXG superfamily; Region: LXG; pfam04740 326423010509 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 326423010510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 326423010511 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 326423010512 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 326423010513 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 326423010514 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 326423010515 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 326423010516 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 326423010517 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 326423010518 Nucleotide binding site [chemical binding]; other site 326423010519 DTAP/Switch II; other site 326423010520 Switch I; other site 326423010521 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 326423010522 Chain length determinant protein; Region: Wzz; cl15801 326423010523 SWIM zinc finger; Region: SWIM; pfam04434 326423010524 SNF2 Helicase protein; Region: DUF3670; pfam12419 326423010525 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 326423010526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326423010527 ATP binding site [chemical binding]; other site 326423010528 putative Mg++ binding site [ion binding]; other site 326423010529 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 326423010530 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326423010531 nucleotide binding region [chemical binding]; other site 326423010532 ATP-binding site [chemical binding]; other site 326423010533 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423010534 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326423010535 active site 326423010536 motif I; other site 326423010537 motif II; other site 326423010538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423010539 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 326423010540 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 326423010541 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 326423010542 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 326423010543 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 326423010544 dimer interface [polypeptide binding]; other site 326423010545 ssDNA binding site [nucleotide binding]; other site 326423010546 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326423010547 YwpF-like protein; Region: YwpF; pfam14183 326423010548 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 326423010549 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 326423010550 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 326423010551 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423010552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326423010553 binding surface 326423010554 TPR motif; other site 326423010555 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423010556 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 326423010557 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 326423010558 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 326423010559 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 326423010560 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 326423010561 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 326423010562 rod shape-determining protein Mbl; Provisional; Region: PRK13928 326423010563 MreB and similar proteins; Region: MreB_like; cd10225 326423010564 nucleotide binding site [chemical binding]; other site 326423010565 Mg binding site [ion binding]; other site 326423010566 putative protofilament interaction site [polypeptide binding]; other site 326423010567 RodZ interaction site [polypeptide binding]; other site 326423010568 Stage III sporulation protein D; Region: SpoIIID; pfam12116 326423010569 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423010570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326423010571 putative Zn2+ binding site [ion binding]; other site 326423010572 putative DNA binding site [nucleotide binding]; other site 326423010573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423010574 putative substrate translocation pore; other site 326423010575 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423010576 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 326423010577 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 326423010578 Na binding site [ion binding]; other site 326423010579 putative substrate binding site [chemical binding]; other site 326423010580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423010581 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423010582 putative substrate translocation pore; other site 326423010583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423010584 Isochorismatase family; Region: Isochorismatase; pfam00857 326423010585 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 326423010586 catalytic triad [active] 326423010587 conserved cis-peptide bond; other site 326423010588 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 326423010589 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 326423010590 Nitrogen regulatory protein P-II; Region: P-II; smart00938 326423010591 cell division protein FtsW; Region: ftsW; TIGR02614 326423010592 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 326423010593 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 326423010594 active site 326423010595 VanZ like family; Region: VanZ; pfam04892 326423010596 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 326423010597 Peptidase family M23; Region: Peptidase_M23; pfam01551 326423010598 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 326423010599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423010600 Coenzyme A binding pocket [chemical binding]; other site 326423010601 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 326423010602 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 326423010603 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 326423010604 putative active site [active] 326423010605 catalytic site [active] 326423010606 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 326423010607 putative active site [active] 326423010608 catalytic site [active] 326423010609 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 326423010610 Predicted transcriptional regulator [Transcription]; Region: COG1959 326423010611 Transcriptional regulator; Region: Rrf2; pfam02082 326423010612 urease subunit alpha; Reviewed; Region: ureC; PRK13207 326423010613 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 326423010614 subunit interactions [polypeptide binding]; other site 326423010615 active site 326423010616 flap region; other site 326423010617 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 326423010618 gamma-beta subunit interface [polypeptide binding]; other site 326423010619 alpha-beta subunit interface [polypeptide binding]; other site 326423010620 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 326423010621 alpha-gamma subunit interface [polypeptide binding]; other site 326423010622 beta-gamma subunit interface [polypeptide binding]; other site 326423010623 CsbD-like; Region: CsbD; cl17424 326423010624 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423010625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326423010626 binding surface 326423010627 TPR motif; other site 326423010628 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 326423010629 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326423010630 FeS/SAM binding site; other site 326423010631 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 326423010632 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 326423010633 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 326423010634 metal ion-dependent adhesion site (MIDAS); other site 326423010635 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 326423010636 metal ion-dependent adhesion site (MIDAS); other site 326423010637 Stage II sporulation protein; Region: SpoIID; pfam08486 326423010638 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 326423010639 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 326423010640 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 326423010641 hinge; other site 326423010642 active site 326423010643 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 326423010644 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 326423010645 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 326423010646 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 326423010647 gamma subunit interface [polypeptide binding]; other site 326423010648 epsilon subunit interface [polypeptide binding]; other site 326423010649 LBP interface [polypeptide binding]; other site 326423010650 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 326423010651 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 326423010652 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 326423010653 alpha subunit interaction interface [polypeptide binding]; other site 326423010654 Walker A motif; other site 326423010655 ATP binding site [chemical binding]; other site 326423010656 Walker B motif; other site 326423010657 inhibitor binding site; inhibition site 326423010658 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 326423010659 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 326423010660 core domain interface [polypeptide binding]; other site 326423010661 delta subunit interface [polypeptide binding]; other site 326423010662 epsilon subunit interface [polypeptide binding]; other site 326423010663 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 326423010664 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 326423010665 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 326423010666 beta subunit interaction interface [polypeptide binding]; other site 326423010667 Walker A motif; other site 326423010668 ATP binding site [chemical binding]; other site 326423010669 Walker B motif; other site 326423010670 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 326423010671 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 326423010672 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 326423010673 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 326423010674 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 326423010675 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 326423010676 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 326423010677 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 326423010678 ATP synthase I chain; Region: ATP_synt_I; pfam03899 326423010679 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326423010680 active site 326423010681 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 326423010682 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 326423010683 dimer interface [polypeptide binding]; other site 326423010684 active site 326423010685 glycine-pyridoxal phosphate binding site [chemical binding]; other site 326423010686 folate binding site [chemical binding]; other site 326423010687 hypothetical protein; Provisional; Region: PRK13690 326423010688 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 326423010689 Low molecular weight phosphatase family; Region: LMWPc; cd00115 326423010690 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 326423010691 active site 326423010692 Predicted membrane protein [Function unknown]; Region: COG1971 326423010693 Domain of unknown function DUF; Region: DUF204; pfam02659 326423010694 Domain of unknown function DUF; Region: DUF204; pfam02659 326423010695 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 326423010696 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 326423010697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326423010698 stage II sporulation protein R; Region: spore_II_R; TIGR02837 326423010699 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 326423010700 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423010701 S-adenosylmethionine binding site [chemical binding]; other site 326423010702 peptide chain release factor 1; Validated; Region: prfA; PRK00591 326423010703 This domain is found in peptide chain release factors; Region: PCRF; smart00937 326423010704 RF-1 domain; Region: RF-1; pfam00472 326423010705 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 326423010706 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326423010707 putative metal binding site [ion binding]; other site 326423010708 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 326423010709 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 326423010710 DNA binding residues [nucleotide binding] 326423010711 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 326423010712 malate dehydrogenase; Provisional; Region: PRK13529 326423010713 Malic enzyme, N-terminal domain; Region: malic; pfam00390 326423010714 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 326423010715 NAD(P) binding site [chemical binding]; other site 326423010716 thymidine kinase; Provisional; Region: PRK04296 326423010717 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 326423010718 transcription termination factor Rho; Provisional; Region: rho; PRK09376 326423010719 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 326423010720 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 326423010721 RNA binding site [nucleotide binding]; other site 326423010722 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 326423010723 multimer interface [polypeptide binding]; other site 326423010724 Walker A motif; other site 326423010725 ATP binding site [chemical binding]; other site 326423010726 Walker B motif; other site 326423010727 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 326423010728 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 326423010729 putative active site [active] 326423010730 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 326423010731 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 326423010732 hinge; other site 326423010733 active site 326423010734 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 326423010735 active site 326423010736 intersubunit interactions; other site 326423010737 catalytic residue [active] 326423010738 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 326423010739 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 326423010740 intersubunit interface [polypeptide binding]; other site 326423010741 active site 326423010742 zinc binding site [ion binding]; other site 326423010743 Na+ binding site [ion binding]; other site 326423010744 Response regulator receiver domain; Region: Response_reg; pfam00072 326423010745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423010746 active site 326423010747 phosphorylation site [posttranslational modification] 326423010748 intermolecular recognition site; other site 326423010749 dimerization interface [polypeptide binding]; other site 326423010750 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 326423010751 CTP synthetase; Validated; Region: pyrG; PRK05380 326423010752 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 326423010753 Catalytic site [active] 326423010754 active site 326423010755 UTP binding site [chemical binding]; other site 326423010756 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 326423010757 active site 326423010758 putative oxyanion hole; other site 326423010759 catalytic triad [active] 326423010760 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 326423010761 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 326423010762 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 326423010763 Cysteine-rich domain; Region: CCG; pfam02754 326423010764 Cysteine-rich domain; Region: CCG; pfam02754 326423010765 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 326423010766 PLD-like domain; Region: PLDc_2; pfam13091 326423010767 putative active site [active] 326423010768 catalytic site [active] 326423010769 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 326423010770 PLD-like domain; Region: PLDc_2; pfam13091 326423010771 putative active site [active] 326423010772 catalytic site [active] 326423010773 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 326423010774 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326423010775 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326423010776 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 326423010777 Walker A/P-loop; other site 326423010778 ATP binding site [chemical binding]; other site 326423010779 Q-loop/lid; other site 326423010780 ABC transporter signature motif; other site 326423010781 Walker B; other site 326423010782 D-loop; other site 326423010783 H-loop/switch region; other site 326423010784 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 326423010785 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 326423010786 putative active site [active] 326423010787 catalytic site [active] 326423010788 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 326423010789 putative active site [active] 326423010790 catalytic site [active] 326423010791 Uncharacterized conserved protein [Function unknown]; Region: COG1284 326423010792 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423010793 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 326423010794 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 326423010795 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 326423010796 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 326423010797 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 326423010798 [4Fe-4S] binding site [ion binding]; other site 326423010799 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 326423010800 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 326423010801 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 326423010802 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 326423010803 molybdopterin cofactor binding site; other site 326423010804 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 326423010805 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 326423010806 ligand binding site [chemical binding]; other site 326423010807 flexible hinge region; other site 326423010808 YwiC-like protein; Region: YwiC; pfam14256 326423010809 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 326423010810 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 326423010811 ligand binding site [chemical binding]; other site 326423010812 flexible hinge region; other site 326423010813 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 326423010814 putative switch regulator; other site 326423010815 non-specific DNA interactions [nucleotide binding]; other site 326423010816 DNA binding site [nucleotide binding] 326423010817 sequence specific DNA binding site [nucleotide binding]; other site 326423010818 putative cAMP binding site [chemical binding]; other site 326423010819 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 326423010820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423010821 putative substrate translocation pore; other site 326423010822 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 326423010823 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 326423010824 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 326423010825 active site 326423010826 HIGH motif; other site 326423010827 KMSK motif region; other site 326423010828 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 326423010829 tRNA binding surface [nucleotide binding]; other site 326423010830 anticodon binding site; other site 326423010831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 326423010832 Uncharacterized conserved protein [Function unknown]; Region: COG3391 326423010833 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 326423010834 Uncharacterized conserved protein [Function unknown]; Region: COG3391 326423010835 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423010836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326423010837 binding surface 326423010838 TPR motif; other site 326423010839 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423010840 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 326423010841 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326423010842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326423010843 non-specific DNA binding site [nucleotide binding]; other site 326423010844 salt bridge; other site 326423010845 sequence-specific DNA binding site [nucleotide binding]; other site 326423010846 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 326423010847 Integral membrane protein DUF95; Region: DUF95; pfam01944 326423010848 agmatinase; Region: agmatinase; TIGR01230 326423010849 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 326423010850 putative active site [active] 326423010851 Mn binding site [ion binding]; other site 326423010852 spermidine synthase; Provisional; Region: PRK00811 326423010853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326423010854 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 326423010855 Transglycosylase; Region: Transgly; pfam00912 326423010856 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 326423010857 YwhD family; Region: YwhD; pfam08741 326423010858 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 326423010859 Peptidase family M50; Region: Peptidase_M50; pfam02163 326423010860 active site 326423010861 putative substrate binding region [chemical binding]; other site 326423010862 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 326423010863 active site 1 [active] 326423010864 dimer interface [polypeptide binding]; other site 326423010865 hexamer interface [polypeptide binding]; other site 326423010866 active site 2 [active] 326423010867 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326423010868 dimerization interface [polypeptide binding]; other site 326423010869 putative DNA binding site [nucleotide binding]; other site 326423010870 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423010871 putative Zn2+ binding site [ion binding]; other site 326423010872 amino acid transporter; Region: 2A0306; TIGR00909 326423010873 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 326423010874 Uncharacterized conserved protein [Function unknown]; Region: COG3465 326423010875 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 326423010876 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326423010877 Zn2+ binding site [ion binding]; other site 326423010878 Mg2+ binding site [ion binding]; other site 326423010879 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 326423010880 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 326423010881 Predicted transcriptional regulators [Transcription]; Region: COG1695 326423010882 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 326423010883 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 326423010884 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326423010885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326423010886 Walker A/P-loop; other site 326423010887 ATP binding site [chemical binding]; other site 326423010888 Q-loop/lid; other site 326423010889 ABC transporter signature motif; other site 326423010890 Walker B; other site 326423010891 D-loop; other site 326423010892 H-loop/switch region; other site 326423010893 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 326423010894 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 326423010895 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 326423010896 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423010897 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423010898 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 326423010899 putative dimerization interface [polypeptide binding]; other site 326423010900 Predicted membrane protein [Function unknown]; Region: COG2855 326423010901 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 326423010902 putative heme peroxidase; Provisional; Region: PRK12276 326423010903 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 326423010904 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 326423010905 putative NAD(P) binding site [chemical binding]; other site 326423010906 putative active site [active] 326423010907 transaminase; Reviewed; Region: PRK08068 326423010908 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326423010909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423010910 homodimer interface [polypeptide binding]; other site 326423010911 catalytic residue [active] 326423010912 H+ Antiporter protein; Region: 2A0121; TIGR00900 326423010913 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 326423010914 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 326423010915 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 326423010916 classical (c) SDRs; Region: SDR_c; cd05233 326423010917 NAD(P) binding site [chemical binding]; other site 326423010918 active site 326423010919 Cupin domain; Region: Cupin_2; pfam07883 326423010920 Cupin domain; Region: Cupin_2; pfam07883 326423010921 Prephenate dehydratase; Region: PDT; pfam00800 326423010922 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 326423010923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423010924 putative substrate translocation pore; other site 326423010925 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 326423010926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423010927 putative substrate translocation pore; other site 326423010928 S-methylmethionine transporter; Provisional; Region: PRK11387 326423010929 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 326423010930 putative metal binding site [ion binding]; other site 326423010931 putative dimer interface [polypeptide binding]; other site 326423010932 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 326423010933 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 326423010934 Glutamate binding site [chemical binding]; other site 326423010935 homodimer interface [polypeptide binding]; other site 326423010936 NAD binding site [chemical binding]; other site 326423010937 catalytic residues [active] 326423010938 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 326423010939 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 326423010940 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 326423010941 NAD(P) binding site [chemical binding]; other site 326423010942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423010943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423010944 dimer interface [polypeptide binding]; other site 326423010945 phosphorylation site [posttranslational modification] 326423010946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423010947 ATP binding site [chemical binding]; other site 326423010948 Mg2+ binding site [ion binding]; other site 326423010949 G-X-G motif; other site 326423010950 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423010951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423010952 active site 326423010953 phosphorylation site [posttranslational modification] 326423010954 intermolecular recognition site; other site 326423010955 dimerization interface [polypeptide binding]; other site 326423010956 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423010957 DNA binding site [nucleotide binding] 326423010958 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 326423010959 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 326423010960 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326423010961 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 326423010962 Walker A/P-loop; other site 326423010963 ATP binding site [chemical binding]; other site 326423010964 Q-loop/lid; other site 326423010965 ABC transporter signature motif; other site 326423010966 Walker B; other site 326423010967 D-loop; other site 326423010968 H-loop/switch region; other site 326423010969 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 326423010970 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 326423010971 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 326423010972 NADP binding site [chemical binding]; other site 326423010973 active site 326423010974 putative substrate binding site [chemical binding]; other site 326423010975 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 326423010976 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 326423010977 NAD binding site [chemical binding]; other site 326423010978 substrate binding site [chemical binding]; other site 326423010979 homodimer interface [polypeptide binding]; other site 326423010980 active site 326423010981 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 326423010982 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 326423010983 substrate binding site; other site 326423010984 tetramer interface; other site 326423010985 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 326423010986 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326423010987 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 326423010988 ligand binding site; other site 326423010989 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 326423010990 NeuB family; Region: NeuB; pfam03102 326423010991 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 326423010992 NeuB binding interface [polypeptide binding]; other site 326423010993 putative substrate binding site [chemical binding]; other site 326423010994 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 326423010995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423010996 Coenzyme A binding pocket [chemical binding]; other site 326423010997 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 326423010998 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 326423010999 inhibitor-cofactor binding pocket; inhibition site 326423011000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423011001 catalytic residue [active] 326423011002 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 326423011003 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 326423011004 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326423011005 active site 326423011006 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 326423011007 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 326423011008 Permease family; Region: Xan_ur_permease; pfam00860 326423011009 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 326423011010 ligand binding site [chemical binding]; other site 326423011011 active site 326423011012 UGI interface [polypeptide binding]; other site 326423011013 catalytic site [active] 326423011014 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 326423011015 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326423011016 active site 326423011017 Predicted transcriptional regulators [Transcription]; Region: COG1695 326423011018 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 326423011019 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 326423011020 dimer interface [polypeptide binding]; other site 326423011021 substrate binding site [chemical binding]; other site 326423011022 ATP binding site [chemical binding]; other site 326423011023 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 326423011024 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 326423011025 substrate binding [chemical binding]; other site 326423011026 active site 326423011027 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 326423011028 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 326423011029 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 326423011030 active site turn [active] 326423011031 phosphorylation site [posttranslational modification] 326423011032 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 326423011033 transcriptional antiterminator BglG; Provisional; Region: PRK09772 326423011034 CAT RNA binding domain; Region: CAT_RBD; smart01061 326423011035 PRD domain; Region: PRD; pfam00874 326423011036 PRD domain; Region: PRD; pfam00874 326423011037 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 326423011038 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 326423011039 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 326423011040 putative active site [active] 326423011041 catalytic triad [active] 326423011042 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 326423011043 PA/protease domain interface [polypeptide binding]; other site 326423011044 putative integrin binding motif; other site 326423011045 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 326423011046 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 326423011047 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 326423011048 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 326423011049 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 326423011050 Homeodomain-like domain; Region: HTH_23; pfam13384 326423011051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 326423011052 HTH-like domain; Region: HTH_21; pfam13276 326423011053 Integrase core domain; Region: rve; pfam00665 326423011054 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 326423011055 dimer interface [polypeptide binding]; other site 326423011056 FMN binding site [chemical binding]; other site 326423011057 NADPH bind site [chemical binding]; other site 326423011058 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 326423011059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423011060 Coenzyme A binding pocket [chemical binding]; other site 326423011061 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 326423011062 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 326423011063 Subunit I/III interface [polypeptide binding]; other site 326423011064 Subunit III/IV interface [polypeptide binding]; other site 326423011065 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 326423011066 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 326423011067 D-pathway; other site 326423011068 Putative ubiquinol binding site [chemical binding]; other site 326423011069 Low-spin heme (heme b) binding site [chemical binding]; other site 326423011070 Putative water exit pathway; other site 326423011071 Binuclear center (heme o3/CuB) [ion binding]; other site 326423011072 K-pathway; other site 326423011073 Putative proton exit pathway; other site 326423011074 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 326423011075 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 326423011076 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 326423011077 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 326423011078 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 326423011079 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 326423011080 galactokinase; Provisional; Region: PRK05322 326423011081 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 326423011082 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 326423011083 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 326423011084 Predicted membrane protein [Function unknown]; Region: COG2246 326423011085 GtrA-like protein; Region: GtrA; pfam04138 326423011086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423011087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423011088 Anti-repressor SinI; Region: SinI; pfam08671 326423011089 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326423011090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423011091 S-adenosylmethionine binding site [chemical binding]; other site 326423011092 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 326423011093 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 326423011094 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 326423011095 catalytic residues [active] 326423011096 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 326423011097 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 326423011098 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 326423011099 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 326423011100 thiamine phosphate binding site [chemical binding]; other site 326423011101 active site 326423011102 pyrophosphate binding site [ion binding]; other site 326423011103 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 326423011104 substrate binding site [chemical binding]; other site 326423011105 multimerization interface [polypeptide binding]; other site 326423011106 ATP binding site [chemical binding]; other site 326423011107 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423011108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423011109 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 326423011110 putative dimerization interface [polypeptide binding]; other site 326423011111 holin-like protein; Validated; Region: PRK01658 326423011112 TIGR00659 family protein; Region: TIGR00659 326423011113 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 326423011114 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 326423011115 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 326423011116 DNA binding residues [nucleotide binding] 326423011117 dimer interface [polypeptide binding]; other site 326423011118 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 326423011119 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 326423011120 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 326423011121 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 326423011122 putative RNA binding site [nucleotide binding]; other site 326423011123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326423011124 S-adenosylmethionine binding site [chemical binding]; other site 326423011125 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326423011126 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 326423011127 active site 326423011128 metal binding site [ion binding]; metal-binding site 326423011129 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 326423011130 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 326423011131 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 326423011132 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 326423011133 active site 326423011134 catalytic residues [active] 326423011135 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 326423011136 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 326423011137 Ligand binding site; other site 326423011138 metal-binding site 326423011139 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 326423011140 synthetase active site [active] 326423011141 NTP binding site [chemical binding]; other site 326423011142 metal binding site [ion binding]; metal-binding site 326423011143 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 326423011144 UbiA prenyltransferase family; Region: UbiA; pfam01040 326423011145 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 326423011146 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 326423011147 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 326423011148 acyl-activating enzyme (AAE) consensus motif; other site 326423011149 AMP binding site [chemical binding]; other site 326423011150 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 326423011151 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 326423011152 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 326423011153 DltD N-terminal region; Region: DltD_N; pfam04915 326423011154 DltD central region; Region: DltD_M; pfam04918 326423011155 DltD C-terminal region; Region: DltD_C; pfam04914 326423011156 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 326423011157 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 326423011158 homodimer interface [polypeptide binding]; other site 326423011159 substrate-cofactor binding pocket; other site 326423011160 catalytic residue [active] 326423011161 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 326423011162 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 326423011163 NAD binding site [chemical binding]; other site 326423011164 sugar binding site [chemical binding]; other site 326423011165 divalent metal binding site [ion binding]; other site 326423011166 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326423011167 dimer interface [polypeptide binding]; other site 326423011168 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 326423011169 methionine cluster; other site 326423011170 active site 326423011171 phosphorylation site [posttranslational modification] 326423011172 metal binding site [ion binding]; metal-binding site 326423011173 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 326423011174 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 326423011175 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 326423011176 active site 326423011177 P-loop; other site 326423011178 phosphorylation site [posttranslational modification] 326423011179 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 326423011180 HTH domain; Region: HTH_11; pfam08279 326423011181 Mga helix-turn-helix domain; Region: Mga; pfam05043 326423011182 PRD domain; Region: PRD; pfam00874 326423011183 PRD domain; Region: PRD; pfam00874 326423011184 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 326423011185 active site 326423011186 P-loop; other site 326423011187 phosphorylation site [posttranslational modification] 326423011188 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 326423011189 active site 326423011190 phosphorylation site [posttranslational modification] 326423011191 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 326423011192 active site 326423011193 DNA binding site [nucleotide binding] 326423011194 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 326423011195 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 326423011196 ABC-ATPase subunit interface; other site 326423011197 dimer interface [polypeptide binding]; other site 326423011198 putative PBP binding regions; other site 326423011199 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 326423011200 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 326423011201 ABC-ATPase subunit interface; other site 326423011202 dimer interface [polypeptide binding]; other site 326423011203 putative PBP binding regions; other site 326423011204 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 326423011205 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 326423011206 intersubunit interface [polypeptide binding]; other site 326423011207 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326423011208 dimerization interface [polypeptide binding]; other site 326423011209 putative DNA binding site [nucleotide binding]; other site 326423011210 putative Zn2+ binding site [ion binding]; other site 326423011211 arsenical pump membrane protein; Provisional; Region: PRK15445 326423011212 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 326423011213 transmembrane helices; other site 326423011214 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 326423011215 active site 326423011216 P-loop; other site 326423011217 phosphorylation site [posttranslational modification] 326423011218 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 326423011219 active site 326423011220 methionine cluster; other site 326423011221 phosphorylation site [posttranslational modification] 326423011222 metal binding site [ion binding]; metal-binding site 326423011223 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 326423011224 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 326423011225 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 326423011226 beta-galactosidase; Region: BGL; TIGR03356 326423011227 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326423011228 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 326423011229 nucleotide binding site [chemical binding]; other site 326423011230 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 326423011231 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 326423011232 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 326423011233 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 326423011234 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 326423011235 tetramer interface [polypeptide binding]; other site 326423011236 heme binding pocket [chemical binding]; other site 326423011237 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 326423011238 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 326423011239 active site 326423011240 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 326423011241 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 326423011242 Na binding site [ion binding]; other site 326423011243 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 326423011244 putative substrate binding site [chemical binding]; other site 326423011245 putative ATP binding site [chemical binding]; other site 326423011246 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 326423011247 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326423011248 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 326423011249 Walker A/P-loop; other site 326423011250 ATP binding site [chemical binding]; other site 326423011251 Q-loop/lid; other site 326423011252 ABC transporter signature motif; other site 326423011253 Walker B; other site 326423011254 D-loop; other site 326423011255 H-loop/switch region; other site 326423011256 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 326423011257 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326423011258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326423011259 ATP binding site [chemical binding]; other site 326423011260 Q-loop/lid; other site 326423011261 ABC transporter signature motif; other site 326423011262 Walker B; other site 326423011263 D-loop; other site 326423011264 H-loop/switch region; other site 326423011265 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 326423011266 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 326423011267 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 326423011268 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 326423011269 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 326423011270 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 326423011271 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 326423011272 putative active site [active] 326423011273 putative metal binding site [ion binding]; other site 326423011274 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 326423011275 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 326423011276 Walker A/P-loop; other site 326423011277 ATP binding site [chemical binding]; other site 326423011278 Q-loop/lid; other site 326423011279 ABC transporter signature motif; other site 326423011280 Walker B; other site 326423011281 D-loop; other site 326423011282 H-loop/switch region; other site 326423011283 TOBE domain; Region: TOBE; pfam03459 326423011284 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 326423011285 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 326423011286 Uncharacterized conserved protein [Function unknown]; Region: COG1284 326423011287 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423011288 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 326423011289 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 326423011290 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 326423011291 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 326423011292 UDP-glucose 4-epimerase; Region: PLN02240 326423011293 NAD binding site [chemical binding]; other site 326423011294 homodimer interface [polypeptide binding]; other site 326423011295 active site 326423011296 substrate binding site [chemical binding]; other site 326423011297 peptidase T; Region: peptidase-T; TIGR01882 326423011298 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 326423011299 metal binding site [ion binding]; metal-binding site 326423011300 dimer interface [polypeptide binding]; other site 326423011301 Tubby C 2; Region: Tub_2; cl02043 326423011302 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 326423011303 substrate binding site [chemical binding]; other site 326423011304 THF binding site; other site 326423011305 zinc-binding site [ion binding]; other site 326423011306 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 326423011307 Methyltransferase domain; Region: Methyltransf_18; pfam12847 326423011308 nucleoside transporter; Region: nupC; TIGR00804 326423011309 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 326423011310 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 326423011311 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 326423011312 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 326423011313 hydroperoxidase II; Provisional; Region: katE; PRK11249 326423011314 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 326423011315 tetramer interface [polypeptide binding]; other site 326423011316 heme binding pocket [chemical binding]; other site 326423011317 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 326423011318 domain interactions; other site 326423011319 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 326423011320 Citrate transporter; Region: CitMHS; pfam03600 326423011321 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 326423011322 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 326423011323 active site 326423011324 active site 326423011325 catalytic residues [active] 326423011326 transcriptional antiterminator BglG; Provisional; Region: PRK09772 326423011327 CAT RNA binding domain; Region: CAT_RBD; smart01061 326423011328 PRD domain; Region: PRD; pfam00874 326423011329 PRD domain; Region: PRD; pfam00874 326423011330 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 326423011331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423011332 putative substrate translocation pore; other site 326423011333 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 326423011334 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 326423011335 ATP binding site [chemical binding]; other site 326423011336 Mg++ binding site [ion binding]; other site 326423011337 motif III; other site 326423011338 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326423011339 nucleotide binding region [chemical binding]; other site 326423011340 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 326423011341 RNA binding site [nucleotide binding]; other site 326423011342 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 326423011343 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 326423011344 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 326423011345 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 326423011346 Amb_all domain; Region: Amb_all; smart00656 326423011347 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 326423011348 EamA-like transporter family; Region: EamA; pfam00892 326423011349 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326423011350 Ligand Binding Site [chemical binding]; other site 326423011351 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 326423011352 beta-galactosidase; Region: BGL; TIGR03356 326423011353 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 326423011354 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 326423011355 active site turn [active] 326423011356 phosphorylation site [posttranslational modification] 326423011357 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 326423011358 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 326423011359 HPr interaction site; other site 326423011360 glycerol kinase (GK) interaction site [polypeptide binding]; other site 326423011361 active site 326423011362 phosphorylation site [posttranslational modification] 326423011363 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b; cd09180 326423011364 PLD-like domain; Region: PLDc_2; pfam13091 326423011365 putative homodimer interface [polypeptide binding]; other site 326423011366 putative active site [active] 326423011367 catalytic site [active] 326423011368 DEAD-like helicases superfamily; Region: DEXDc; smart00487 326423011369 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326423011370 ATP binding site [chemical binding]; other site 326423011371 putative Mg++ binding site [ion binding]; other site 326423011372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326423011373 nucleotide binding region [chemical binding]; other site 326423011374 ATP-binding site [chemical binding]; other site 326423011375 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 326423011376 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 326423011377 active site 326423011378 8-oxo-dGMP binding site [chemical binding]; other site 326423011379 nudix motif; other site 326423011380 metal binding site [ion binding]; metal-binding site 326423011381 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 326423011382 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 326423011383 substrate binding site [chemical binding]; other site 326423011384 active site 326423011385 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 326423011386 hexamer interface [polypeptide binding]; other site 326423011387 RNA binding site [nucleotide binding]; other site 326423011388 Histidine-zinc binding site [chemical binding]; other site 326423011389 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 326423011390 active sites [active] 326423011391 tetramer interface [polypeptide binding]; other site 326423011392 urocanate hydratase; Provisional; Region: PRK05414 326423011393 imidazolonepropionase; Validated; Region: PRK09356 326423011394 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 326423011395 active site 326423011396 Agmatinase-like family; Region: Agmatinase-like; cd09990 326423011397 agmatinase; Region: agmatinase; TIGR01230 326423011398 active site 326423011399 oligomer interface [polypeptide binding]; other site 326423011400 Mn binding site [ion binding]; other site 326423011401 S-methylmethionine transporter; Provisional; Region: PRK11387 326423011402 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 326423011403 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 326423011404 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 326423011405 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 326423011406 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 326423011407 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 326423011408 Nucleoside recognition; Region: Gate; pfam07670 326423011409 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 326423011410 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 326423011411 intersubunit interface [polypeptide binding]; other site 326423011412 active site 326423011413 catalytic residue [active] 326423011414 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 326423011415 MarR family; Region: MarR_2; pfam12802 326423011416 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 326423011417 sugar phosphate phosphatase; Provisional; Region: PRK10513 326423011418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423011419 active site 326423011420 motif I; other site 326423011421 motif II; other site 326423011422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326423011423 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 326423011424 SlyX; Region: SlyX; cl01090 326423011425 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 326423011426 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 326423011427 putative ligand binding residues [chemical binding]; other site 326423011428 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 326423011429 Homeodomain-like domain; Region: HTH_23; pfam13384 326423011430 putative transposase OrfB; Reviewed; Region: PHA02517 326423011431 HTH-like domain; Region: HTH_21; pfam13276 326423011432 Integrase core domain; Region: rve; pfam00665 326423011433 Integrase core domain; Region: rve_3; cl15866 326423011434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 326423011435 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326423011436 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326423011437 Walker A/P-loop; other site 326423011438 ATP binding site [chemical binding]; other site 326423011439 Q-loop/lid; other site 326423011440 ABC transporter signature motif; other site 326423011441 Walker B; other site 326423011442 D-loop; other site 326423011443 H-loop/switch region; other site 326423011444 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423011445 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 326423011446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423011447 ATP binding site [chemical binding]; other site 326423011448 Mg2+ binding site [ion binding]; other site 326423011449 G-X-G motif; other site 326423011450 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423011451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423011452 active site 326423011453 phosphorylation site [posttranslational modification] 326423011454 intermolecular recognition site; other site 326423011455 dimerization interface [polypeptide binding]; other site 326423011456 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423011457 DNA binding site [nucleotide binding] 326423011458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423011459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423011460 dimer interface [polypeptide binding]; other site 326423011461 phosphorylation site [posttranslational modification] 326423011462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423011463 ATP binding site [chemical binding]; other site 326423011464 Mg2+ binding site [ion binding]; other site 326423011465 G-X-G motif; other site 326423011466 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423011467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423011468 active site 326423011469 phosphorylation site [posttranslational modification] 326423011470 intermolecular recognition site; other site 326423011471 dimerization interface [polypeptide binding]; other site 326423011472 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423011473 DNA binding site [nucleotide binding] 326423011474 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326423011475 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 326423011476 Walker A/P-loop; other site 326423011477 ATP binding site [chemical binding]; other site 326423011478 Q-loop/lid; other site 326423011479 ABC transporter signature motif; other site 326423011480 Walker B; other site 326423011481 D-loop; other site 326423011482 H-loop/switch region; other site 326423011483 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 326423011484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 326423011485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 326423011486 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 326423011487 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 326423011488 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 326423011489 intersubunit interface [polypeptide binding]; other site 326423011490 active site 326423011491 zinc binding site [ion binding]; other site 326423011492 Na+ binding site [ion binding]; other site 326423011493 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 326423011494 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 326423011495 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 326423011496 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 326423011497 DNA interaction; other site 326423011498 Metal-binding active site; metal-binding site 326423011499 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 326423011500 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 326423011501 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 326423011502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423011503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423011504 putative substrate translocation pore; other site 326423011505 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 326423011506 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 326423011507 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 326423011508 PYR/PP interface [polypeptide binding]; other site 326423011509 dimer interface [polypeptide binding]; other site 326423011510 TPP binding site [chemical binding]; other site 326423011511 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 326423011512 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 326423011513 TPP-binding site; other site 326423011514 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326423011515 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 326423011516 substrate binding site [chemical binding]; other site 326423011517 ATP binding site [chemical binding]; other site 326423011518 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 326423011519 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 326423011520 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 326423011521 tetrameric interface [polypeptide binding]; other site 326423011522 NAD binding site [chemical binding]; other site 326423011523 catalytic residues [active] 326423011524 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 326423011525 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 326423011526 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 326423011527 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326423011528 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326423011529 active site 326423011530 catalytic tetrad [active] 326423011531 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 326423011532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423011533 putative substrate translocation pore; other site 326423011534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423011535 heat shock protein 90; Provisional; Region: PRK05218 326423011536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423011537 ATP binding site [chemical binding]; other site 326423011538 Mg2+ binding site [ion binding]; other site 326423011539 G-X-G motif; other site 326423011540 short chain dehydrogenase; Validated; Region: PRK08589 326423011541 classical (c) SDRs; Region: SDR_c; cd05233 326423011542 NAD(P) binding site [chemical binding]; other site 326423011543 active site 326423011544 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326423011545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423011546 active site 326423011547 phosphorylation site [posttranslational modification] 326423011548 intermolecular recognition site; other site 326423011549 dimerization interface [polypeptide binding]; other site 326423011550 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326423011551 DNA binding residues [nucleotide binding] 326423011552 dimerization interface [polypeptide binding]; other site 326423011553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326423011554 Histidine kinase; Region: HisKA_3; pfam07730 326423011555 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 326423011556 ATP binding site [chemical binding]; other site 326423011557 Mg2+ binding site [ion binding]; other site 326423011558 G-X-G motif; other site 326423011559 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 326423011560 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 326423011561 putative di-iron ligands [ion binding]; other site 326423011562 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423011563 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423011564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326423011565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326423011566 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 326423011567 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 326423011568 NAD(P) binding site [chemical binding]; other site 326423011569 catalytic residues [active] 326423011570 FOG: WD40-like repeat [Function unknown]; Region: COG1520 326423011571 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 326423011572 Trp docking motif [polypeptide binding]; other site 326423011573 active site 326423011574 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326423011575 putative DNA binding site [nucleotide binding]; other site 326423011576 dimerization interface [polypeptide binding]; other site 326423011577 putative Zn2+ binding site [ion binding]; other site 326423011578 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 326423011579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423011580 putative substrate translocation pore; other site 326423011581 RDD family; Region: RDD; pfam06271 326423011582 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326423011583 active site 326423011584 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 326423011585 peroxiredoxin; Region: AhpC; TIGR03137 326423011586 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 326423011587 dimer interface [polypeptide binding]; other site 326423011588 decamer (pentamer of dimers) interface [polypeptide binding]; other site 326423011589 catalytic triad [active] 326423011590 peroxidatic and resolving cysteines [active] 326423011591 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 326423011592 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 326423011593 catalytic residue [active] 326423011594 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 326423011595 catalytic residues [active] 326423011596 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326423011597 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326423011598 Fic family protein [Function unknown]; Region: COG3177 326423011599 Fic/DOC family; Region: Fic; pfam02661 326423011600 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 326423011601 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 326423011602 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 326423011603 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 326423011604 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 326423011605 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 326423011606 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 326423011607 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 326423011608 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 326423011609 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 326423011610 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 326423011611 metal-binding site 326423011612 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 326423011613 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 326423011614 XdhC Rossmann domain; Region: XdhC_C; pfam13478 326423011615 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 326423011616 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 326423011617 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 326423011618 PGAP1-like protein; Region: PGAP1; pfam07819 326423011619 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 326423011620 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 326423011621 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326423011622 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326423011623 active site 326423011624 catalytic tetrad [active] 326423011625 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326423011626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423011627 Coenzyme A binding pocket [chemical binding]; other site 326423011628 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423011629 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326423011630 Arginase family; Region: Arginase; cd09989 326423011631 agmatinase; Region: agmatinase; TIGR01230 326423011632 active site 326423011633 Mn binding site [ion binding]; other site 326423011634 oligomer interface [polypeptide binding]; other site 326423011635 S-methylmethionine transporter; Provisional; Region: PRK11387 326423011636 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 326423011637 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326423011638 inhibitor-cofactor binding pocket; inhibition site 326423011639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326423011640 catalytic residue [active] 326423011641 PAS domain; Region: PAS_9; pfam13426 326423011642 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 326423011643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326423011644 Walker A motif; other site 326423011645 ATP binding site [chemical binding]; other site 326423011646 Walker B motif; other site 326423011647 arginine finger; other site 326423011648 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 326423011649 Cupin-like domain; Region: Cupin_8; pfam13621 326423011650 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 326423011651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326423011652 Walker A/P-loop; other site 326423011653 ATP binding site [chemical binding]; other site 326423011654 Q-loop/lid; other site 326423011655 ABC transporter signature motif; other site 326423011656 Walker B; other site 326423011657 D-loop; other site 326423011658 H-loop/switch region; other site 326423011659 ABC transporter; Region: ABC_tran_2; pfam12848 326423011660 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326423011661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423011662 putative substrate translocation pore; other site 326423011663 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423011664 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 326423011665 hypothetical protein; Provisional; Region: PRK08328 326423011666 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 326423011667 ATP binding site [chemical binding]; other site 326423011668 substrate interface [chemical binding]; other site 326423011669 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326423011670 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326423011671 dimerization interface [polypeptide binding]; other site 326423011672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423011673 dimer interface [polypeptide binding]; other site 326423011674 phosphorylation site [posttranslational modification] 326423011675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423011676 ATP binding site [chemical binding]; other site 326423011677 Mg2+ binding site [ion binding]; other site 326423011678 G-X-G motif; other site 326423011679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 326423011680 DNA binding site [nucleotide binding] 326423011681 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 326423011682 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 326423011683 protein binding site [polypeptide binding]; other site 326423011684 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 326423011685 YycH protein; Region: YycI; cl02015 326423011686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 326423011687 YycH protein; Region: YycH; pfam07435 326423011688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 326423011689 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326423011690 dimerization interface [polypeptide binding]; other site 326423011691 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 326423011692 putative active site [active] 326423011693 heme pocket [chemical binding]; other site 326423011694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326423011695 dimer interface [polypeptide binding]; other site 326423011696 phosphorylation site [posttranslational modification] 326423011697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326423011698 ATP binding site [chemical binding]; other site 326423011699 Mg2+ binding site [ion binding]; other site 326423011700 G-X-G motif; other site 326423011701 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326423011702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326423011703 active site 326423011704 phosphorylation site [posttranslational modification] 326423011705 intermolecular recognition site; other site 326423011706 dimerization interface [polypeptide binding]; other site 326423011707 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326423011708 DNA binding site [nucleotide binding] 326423011709 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 326423011710 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 326423011711 GDP-binding site [chemical binding]; other site 326423011712 ACT binding site; other site 326423011713 IMP binding site; other site 326423011714 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326423011715 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 326423011716 active site 326423011717 replicative DNA helicase; Provisional; Region: PRK05748 326423011718 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 326423011719 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 326423011720 Walker A motif; other site 326423011721 ATP binding site [chemical binding]; other site 326423011722 Walker B motif; other site 326423011723 DNA binding loops [nucleotide binding] 326423011724 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 326423011725 YycC-like protein; Region: YycC; pfam14174 326423011726 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326423011727 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326423011728 Phosphotransferase enzyme family; Region: APH; pfam01636 326423011729 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326423011730 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 326423011731 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 326423011732 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326423011733 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326423011734 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 326423011735 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 326423011736 active site 326423011737 substrate binding site [chemical binding]; other site 326423011738 ATP binding site [chemical binding]; other site 326423011739 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 326423011740 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 326423011741 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 326423011742 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 326423011743 diguanylate cyclase; Region: GGDEF; smart00267 326423011744 DHH family; Region: DHH; pfam01368 326423011745 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 326423011746 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 326423011747 Predicted transcriptional regulators [Transcription]; Region: COG1733 326423011748 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 326423011749 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 326423011750 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 326423011751 DHHA2 domain; Region: DHHA2; pfam02833 326423011752 EamA-like transporter family; Region: EamA; pfam00892 326423011753 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 326423011754 EamA-like transporter family; Region: EamA; pfam00892 326423011755 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 326423011756 active site 326423011757 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 326423011758 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 326423011759 substrate binding [chemical binding]; other site 326423011760 active site 326423011761 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 326423011762 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 326423011763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326423011764 DNA-binding site [nucleotide binding]; DNA binding site 326423011765 FCD domain; Region: FCD; pfam07729 326423011766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 326423011767 DinB superfamily; Region: DinB_2; pfam12867 326423011768 H+ Antiporter protein; Region: 2A0121; TIGR00900 326423011769 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423011770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423011771 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326423011772 dimerization interface [polypeptide binding]; other site 326423011773 LysE type translocator; Region: LysE; cl00565 326423011774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423011775 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326423011776 putative substrate translocation pore; other site 326423011777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423011778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423011779 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 326423011780 putative dimerization interface [polypeptide binding]; other site 326423011781 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 326423011782 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 326423011783 dimer interface [polypeptide binding]; other site 326423011784 FMN binding site [chemical binding]; other site 326423011785 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423011786 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326423011787 putative DNA binding site [nucleotide binding]; other site 326423011788 putative Zn2+ binding site [ion binding]; other site 326423011789 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423011790 Uncharacterized conserved protein [Function unknown]; Region: COG1284 326423011791 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 326423011792 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 326423011793 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326423011794 MarR family; Region: MarR; pfam01047 326423011795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423011796 Coenzyme A binding pocket [chemical binding]; other site 326423011797 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 326423011798 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 326423011799 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 326423011800 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326423011801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326423011802 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 326423011803 putative dimerization interface [polypeptide binding]; other site 326423011804 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 326423011805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326423011806 NAD(P) binding site [chemical binding]; other site 326423011807 active site 326423011808 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 326423011809 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 326423011810 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326423011811 active site 326423011812 ATP binding site [chemical binding]; other site 326423011813 substrate binding site [chemical binding]; other site 326423011814 activation loop (A-loop); other site 326423011815 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 326423011816 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 326423011817 catalytic residues [active] 326423011818 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 326423011819 CAAX protease self-immunity; Region: Abi; pfam02517 326423011820 benzoate transport; Region: 2A0115; TIGR00895 326423011821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423011822 putative substrate translocation pore; other site 326423011823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326423011824 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 326423011825 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326423011826 putative metal binding site [ion binding]; other site 326423011827 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326423011828 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326423011829 DNA binding site [nucleotide binding] 326423011830 domain linker motif; other site 326423011831 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 326423011832 putative dimerization interface [polypeptide binding]; other site 326423011833 putative ligand binding site [chemical binding]; other site 326423011834 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 326423011835 active site 326423011836 putative catalytic site [active] 326423011837 DNA binding site [nucleotide binding] 326423011838 putative phosphate binding site [ion binding]; other site 326423011839 metal binding site A [ion binding]; metal-binding site 326423011840 AP binding site [nucleotide binding]; other site 326423011841 metal binding site B [ion binding]; metal-binding site 326423011842 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 326423011843 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 326423011844 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 326423011845 DNA binding site [nucleotide binding] 326423011846 active site 326423011847 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 326423011848 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 326423011849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326423011850 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326423011851 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 326423011852 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 326423011853 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 326423011854 dimer interface [polypeptide binding]; other site 326423011855 ssDNA binding site [nucleotide binding]; other site 326423011856 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326423011857 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 326423011858 GTP-binding protein YchF; Reviewed; Region: PRK09601 326423011859 YchF GTPase; Region: YchF; cd01900 326423011860 G1 box; other site 326423011861 GTP/Mg2+ binding site [chemical binding]; other site 326423011862 Switch I region; other site 326423011863 G2 box; other site 326423011864 Switch II region; other site 326423011865 G3 box; other site 326423011866 G4 box; other site 326423011867 G5 box; other site 326423011868 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 326423011869 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 326423011870 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 326423011871 putative [4Fe-4S] binding site [ion binding]; other site 326423011872 putative molybdopterin cofactor binding site [chemical binding]; other site 326423011873 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 326423011874 molybdopterin cofactor binding site; other site 326423011875 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 326423011876 Uncharacterized membrane protein [Function unknown]; Region: COG3949 326423011877 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 326423011878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326423011879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326423011880 Coenzyme A binding pocket [chemical binding]; other site 326423011881 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 326423011882 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 326423011883 ParB-like nuclease domain; Region: ParB; smart00470 326423011884 KorB domain; Region: KorB; pfam08535 326423011885 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 326423011886 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326423011887 P-loop; other site 326423011888 Magnesium ion binding site [ion binding]; other site 326423011889 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326423011890 Magnesium ion binding site [ion binding]; other site 326423011891 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326423011892 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 326423011893 ParB-like nuclease domain; Region: ParB; smart00470 326423011894 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 326423011895 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 326423011896 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 326423011897 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 326423011898 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 326423011899 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 326423011900 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 326423011901 trmE is a tRNA modification GTPase; Region: trmE; cd04164 326423011902 G1 box; other site 326423011903 GTP/Mg2+ binding site [chemical binding]; other site 326423011904 Switch I region; other site 326423011905 G2 box; other site 326423011906 Switch II region; other site 326423011907 G3 box; other site 326423011908 G4 box; other site 326423011909 G5 box; other site 326423011910 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 326423011911 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 326423011912 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 326423011913 G-X-X-G motif; other site 326423011914 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 326423011915 RxxxH motif; other site 326423011916 OxaA-like protein precursor; Validated; Region: PRK02944 326423011917 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 326423011918 ribonuclease P; Reviewed; Region: rnpA; PRK00499 326423011919 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399