-- dump date 20140618_211143 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1001582000001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1001582000002 TPR motif; other site 1001582000003 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582000004 binding surface 1001582000005 Replication protein; Region: Rep_1; pfam01446 1001582000006 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1001582000007 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1001582000008 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1001582000009 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1001582000010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582000011 Walker A motif; other site 1001582000012 ATP binding site [chemical binding]; other site 1001582000013 Walker B motif; other site 1001582000014 arginine finger; other site 1001582000015 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1001582000016 DnaA box-binding interface [nucleotide binding]; other site 1001582000017 DNA polymerase III subunit beta; Validated; Region: PRK05643 1001582000018 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1001582000019 putative DNA binding surface [nucleotide binding]; other site 1001582000020 dimer interface [polypeptide binding]; other site 1001582000021 beta-clamp/clamp loader binding surface; other site 1001582000022 beta-clamp/translesion DNA polymerase binding surface; other site 1001582000023 S4 domain; Region: S4_2; pfam13275 1001582000024 recombination protein F; Reviewed; Region: recF; PRK00064 1001582000025 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1001582000026 Walker A/P-loop; other site 1001582000027 ATP binding site [chemical binding]; other site 1001582000028 Q-loop/lid; other site 1001582000029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582000030 ABC transporter signature motif; other site 1001582000031 Walker B; other site 1001582000032 D-loop; other site 1001582000033 H-loop/switch region; other site 1001582000034 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1001582000035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582000036 ATP binding site [chemical binding]; other site 1001582000037 Mg2+ binding site [ion binding]; other site 1001582000038 G-X-G motif; other site 1001582000039 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1001582000040 anchoring element; other site 1001582000041 dimer interface [polypeptide binding]; other site 1001582000042 ATP binding site [chemical binding]; other site 1001582000043 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1001582000044 active site 1001582000045 putative metal-binding site [ion binding]; other site 1001582000046 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1001582000047 DNA gyrase subunit A; Validated; Region: PRK05560 1001582000048 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1001582000049 CAP-like domain; other site 1001582000050 active site 1001582000051 primary dimer interface [polypeptide binding]; other site 1001582000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001582000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001582000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001582000055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001582000056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001582000057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001582000058 YaaC-like Protein; Region: YaaC; pfam14175 1001582000059 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1001582000060 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1001582000061 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1001582000062 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1001582000063 active site 1001582000064 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1001582000065 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1001582000066 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1001582000067 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1001582000068 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1001582000069 active site 1001582000070 multimer interface [polypeptide binding]; other site 1001582000071 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1001582000072 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1001582000073 predicted active site [active] 1001582000074 catalytic triad [active] 1001582000075 seryl-tRNA synthetase; Provisional; Region: PRK05431 1001582000076 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1001582000077 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1001582000078 dimer interface [polypeptide binding]; other site 1001582000079 active site 1001582000080 motif 1; other site 1001582000081 motif 2; other site 1001582000082 motif 3; other site 1001582000083 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1001582000084 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1001582000085 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1001582000086 Substrate-binding site [chemical binding]; other site 1001582000087 Substrate specificity [chemical binding]; other site 1001582000088 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1001582000089 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1001582000090 Substrate-binding site [chemical binding]; other site 1001582000091 Substrate specificity [chemical binding]; other site 1001582000092 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1001582000093 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582000094 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582000095 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1001582000096 active site 1001582000097 Isochorismatase family; Region: Isochorismatase; pfam00857 1001582000098 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1001582000099 catalytic triad [active] 1001582000100 conserved cis-peptide bond; other site 1001582000101 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1001582000102 nucleoside/Zn binding site; other site 1001582000103 dimer interface [polypeptide binding]; other site 1001582000104 catalytic motif [active] 1001582000105 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1001582000106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582000107 Walker A motif; other site 1001582000108 ATP binding site [chemical binding]; other site 1001582000109 Walker B motif; other site 1001582000110 arginine finger; other site 1001582000111 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1001582000112 hypothetical protein; Validated; Region: PRK00153 1001582000113 recombination protein RecR; Reviewed; Region: recR; PRK00076 1001582000114 RecR protein; Region: RecR; pfam02132 1001582000115 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1001582000116 putative active site [active] 1001582000117 putative metal-binding site [ion binding]; other site 1001582000118 tetramer interface [polypeptide binding]; other site 1001582000119 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1001582000120 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 1001582000121 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1001582000122 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 1001582000123 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1001582000124 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1001582000125 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1001582000126 homodimer interface [polypeptide binding]; other site 1001582000127 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582000128 catalytic residue [active] 1001582000129 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1001582000130 thymidylate kinase; Validated; Region: tmk; PRK00698 1001582000131 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1001582000132 TMP-binding site; other site 1001582000133 ATP-binding site [chemical binding]; other site 1001582000134 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1001582000135 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1001582000136 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1001582000137 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1001582000138 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1001582000139 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1001582000140 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1001582000141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582000142 S-adenosylmethionine binding site [chemical binding]; other site 1001582000143 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1001582000144 GIY-YIG motif/motif A; other site 1001582000145 putative active site [active] 1001582000146 putative metal binding site [ion binding]; other site 1001582000147 Predicted methyltransferases [General function prediction only]; Region: COG0313 1001582000148 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1001582000149 putative SAM binding site [chemical binding]; other site 1001582000150 putative homodimer interface [polypeptide binding]; other site 1001582000151 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1001582000152 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1001582000153 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1001582000154 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1001582000155 active site 1001582000156 HIGH motif; other site 1001582000157 KMSKS motif; other site 1001582000158 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1001582000159 tRNA binding surface [nucleotide binding]; other site 1001582000160 anticodon binding site; other site 1001582000161 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1001582000162 dimer interface [polypeptide binding]; other site 1001582000163 putative tRNA-binding site [nucleotide binding]; other site 1001582000164 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1001582000165 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1001582000166 active site 1001582000167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1001582000168 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1001582000169 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1001582000170 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1001582000171 G5 domain; Region: G5; pfam07501 1001582000172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1001582000173 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1001582000174 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1001582000175 putative active site [active] 1001582000176 putative metal binding site [ion binding]; other site 1001582000177 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1001582000178 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1001582000179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582000180 S-adenosylmethionine binding site [chemical binding]; other site 1001582000181 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 1001582000182 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1001582000183 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1001582000184 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1001582000185 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1001582000186 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1001582000187 pur operon repressor; Provisional; Region: PRK09213 1001582000188 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1001582000189 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001582000190 active site 1001582000191 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1001582000192 homotrimer interaction site [polypeptide binding]; other site 1001582000193 putative active site [active] 1001582000194 regulatory protein SpoVG; Reviewed; Region: PRK13259 1001582000195 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1001582000196 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1001582000197 Substrate binding site; other site 1001582000198 Mg++ binding site; other site 1001582000199 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1001582000200 active site 1001582000201 substrate binding site [chemical binding]; other site 1001582000202 CoA binding site [chemical binding]; other site 1001582000203 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1001582000204 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1001582000205 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001582000206 active site 1001582000207 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1001582000208 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1001582000209 5S rRNA interface [nucleotide binding]; other site 1001582000210 CTC domain interface [polypeptide binding]; other site 1001582000211 L16 interface [polypeptide binding]; other site 1001582000212 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1001582000213 putative active site [active] 1001582000214 catalytic residue [active] 1001582000215 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1001582000216 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1001582000217 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1001582000218 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001582000219 ATP binding site [chemical binding]; other site 1001582000220 putative Mg++ binding site [ion binding]; other site 1001582000221 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001582000222 nucleotide binding region [chemical binding]; other site 1001582000223 ATP-binding site [chemical binding]; other site 1001582000224 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1001582000225 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1001582000226 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1001582000227 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1001582000228 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1001582000229 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1001582000230 putative SAM binding site [chemical binding]; other site 1001582000231 putative homodimer interface [polypeptide binding]; other site 1001582000232 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1001582000233 homodimer interface [polypeptide binding]; other site 1001582000234 metal binding site [ion binding]; metal-binding site 1001582000235 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1001582000236 homodimer interface [polypeptide binding]; other site 1001582000237 active site 1001582000238 putative chemical substrate binding site [chemical binding]; other site 1001582000239 metal binding site [ion binding]; metal-binding site 1001582000240 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001582000241 RNA binding surface [nucleotide binding]; other site 1001582000242 sporulation protein YabP; Region: spore_yabP; TIGR02892 1001582000243 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1001582000244 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1001582000245 Septum formation initiator; Region: DivIC; pfam04977 1001582000246 hypothetical protein; Provisional; Region: PRK08582 1001582000247 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1001582000248 RNA binding site [nucleotide binding]; other site 1001582000249 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1001582000250 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1001582000251 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1001582000252 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1001582000253 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1001582000254 metal ion-dependent adhesion site (MIDAS); other site 1001582000255 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1001582000256 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1001582000257 active site 1001582000258 ATP binding site [chemical binding]; other site 1001582000259 substrate binding site [chemical binding]; other site 1001582000260 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1001582000261 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1001582000262 Ligand Binding Site [chemical binding]; other site 1001582000263 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1001582000264 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001582000265 active site 1001582000266 FtsH Extracellular; Region: FtsH_ext; pfam06480 1001582000267 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1001582000268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582000269 Walker A motif; other site 1001582000270 ATP binding site [chemical binding]; other site 1001582000271 Walker B motif; other site 1001582000272 arginine finger; other site 1001582000273 Peptidase family M41; Region: Peptidase_M41; pfam01434 1001582000274 pantothenate kinase; Reviewed; Region: PRK13318 1001582000275 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1001582000276 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1001582000277 dimerization interface [polypeptide binding]; other site 1001582000278 domain crossover interface; other site 1001582000279 redox-dependent activation switch; other site 1001582000280 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1001582000281 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1001582000282 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1001582000283 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1001582000284 dimer interface [polypeptide binding]; other site 1001582000285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582000286 catalytic residue [active] 1001582000287 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1001582000288 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1001582000289 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1001582000290 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1001582000291 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1001582000292 glutamine binding [chemical binding]; other site 1001582000293 catalytic triad [active] 1001582000294 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1001582000295 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1001582000296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582000297 catalytic residue [active] 1001582000298 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1001582000299 dihydropteroate synthase; Region: DHPS; TIGR01496 1001582000300 substrate binding pocket [chemical binding]; other site 1001582000301 dimer interface [polypeptide binding]; other site 1001582000302 inhibitor binding site; inhibition site 1001582000303 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1001582000304 homooctamer interface [polypeptide binding]; other site 1001582000305 active site 1001582000306 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1001582000307 catalytic center binding site [active] 1001582000308 ATP binding site [chemical binding]; other site 1001582000309 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001582000310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582000311 non-specific DNA binding site [nucleotide binding]; other site 1001582000312 salt bridge; other site 1001582000313 sequence-specific DNA binding site [nucleotide binding]; other site 1001582000314 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1001582000315 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1001582000316 FMN binding site [chemical binding]; other site 1001582000317 active site 1001582000318 catalytic residues [active] 1001582000319 substrate binding site [chemical binding]; other site 1001582000320 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1001582000321 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1001582000322 dimer interface [polypeptide binding]; other site 1001582000323 putative anticodon binding site; other site 1001582000324 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1001582000325 motif 1; other site 1001582000326 active site 1001582000327 motif 2; other site 1001582000328 motif 3; other site 1001582000329 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1001582000330 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1001582000331 UvrB/uvrC motif; Region: UVR; pfam02151 1001582000332 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1001582000333 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1001582000334 ADP binding site [chemical binding]; other site 1001582000335 phosphagen binding site; other site 1001582000336 substrate specificity loop; other site 1001582000337 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1001582000338 Clp amino terminal domain; Region: Clp_N; pfam02861 1001582000339 Clp amino terminal domain; Region: Clp_N; pfam02861 1001582000340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582000341 Walker A motif; other site 1001582000342 ATP binding site [chemical binding]; other site 1001582000343 Walker B motif; other site 1001582000344 arginine finger; other site 1001582000345 UvrB/uvrC motif; Region: UVR; pfam02151 1001582000346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582000347 Walker A motif; other site 1001582000348 ATP binding site [chemical binding]; other site 1001582000349 Walker B motif; other site 1001582000350 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1001582000351 DNA repair protein RadA; Provisional; Region: PRK11823 1001582000352 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1001582000353 Walker A motif/ATP binding site; other site 1001582000354 ATP binding site [chemical binding]; other site 1001582000355 Walker B motif; other site 1001582000356 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1001582000357 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1001582000358 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1001582000359 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1001582000360 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1001582000361 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1001582000362 putative active site [active] 1001582000363 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1001582000364 substrate binding site; other site 1001582000365 dimer interface; other site 1001582000366 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1001582000367 homotrimer interaction site [polypeptide binding]; other site 1001582000368 zinc binding site [ion binding]; other site 1001582000369 CDP-binding sites; other site 1001582000370 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1001582000371 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1001582000372 HIGH motif; other site 1001582000373 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1001582000374 active site 1001582000375 KMSKS motif; other site 1001582000376 serine O-acetyltransferase; Region: cysE; TIGR01172 1001582000377 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1001582000378 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1001582000379 trimer interface [polypeptide binding]; other site 1001582000380 active site 1001582000381 substrate binding site [chemical binding]; other site 1001582000382 CoA binding site [chemical binding]; other site 1001582000383 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1001582000384 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1001582000385 active site 1001582000386 HIGH motif; other site 1001582000387 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1001582000388 KMSKS motif; other site 1001582000389 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1001582000390 tRNA binding surface [nucleotide binding]; other site 1001582000391 anticodon binding site; other site 1001582000392 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1001582000393 active site 1001582000394 metal binding site [ion binding]; metal-binding site 1001582000395 dimerization interface [polypeptide binding]; other site 1001582000396 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1001582000397 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1001582000398 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1001582000399 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1001582000400 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1001582000401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001582000402 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1001582000403 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1001582000404 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1001582000405 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1001582000406 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1001582000407 putative homodimer interface [polypeptide binding]; other site 1001582000408 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1001582000409 heterodimer interface [polypeptide binding]; other site 1001582000410 homodimer interface [polypeptide binding]; other site 1001582000411 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1001582000412 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1001582000413 L7/L12 interface [polypeptide binding]; other site 1001582000414 23S rRNA interface [nucleotide binding]; other site 1001582000415 L25 interface [polypeptide binding]; other site 1001582000416 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1001582000417 mRNA/rRNA interface [nucleotide binding]; other site 1001582000418 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1001582000419 23S rRNA interface [nucleotide binding]; other site 1001582000420 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1001582000421 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1001582000422 core dimer interface [polypeptide binding]; other site 1001582000423 peripheral dimer interface [polypeptide binding]; other site 1001582000424 L10 interface [polypeptide binding]; other site 1001582000425 L11 interface [polypeptide binding]; other site 1001582000426 putative EF-Tu interaction site [polypeptide binding]; other site 1001582000427 putative EF-G interaction site [polypeptide binding]; other site 1001582000428 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1001582000429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582000430 S-adenosylmethionine binding site [chemical binding]; other site 1001582000431 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1001582000432 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1001582000433 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1001582000434 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1001582000435 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1001582000436 RPB1 interaction site [polypeptide binding]; other site 1001582000437 RPB10 interaction site [polypeptide binding]; other site 1001582000438 RPB11 interaction site [polypeptide binding]; other site 1001582000439 RPB3 interaction site [polypeptide binding]; other site 1001582000440 RPB12 interaction site [polypeptide binding]; other site 1001582000441 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1001582000442 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1001582000443 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1001582000444 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1001582000445 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1001582000446 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1001582000447 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1001582000448 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1001582000449 G-loop; other site 1001582000450 DNA binding site [nucleotide binding] 1001582000451 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1001582000452 30S ribosomal protein S7; Validated; Region: PRK05302 1001582000453 elongation factor G; Reviewed; Region: PRK00007 1001582000454 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1001582000455 G1 box; other site 1001582000456 putative GEF interaction site [polypeptide binding]; other site 1001582000457 GTP/Mg2+ binding site [chemical binding]; other site 1001582000458 Switch I region; other site 1001582000459 G2 box; other site 1001582000460 G3 box; other site 1001582000461 Switch II region; other site 1001582000462 G4 box; other site 1001582000463 G5 box; other site 1001582000464 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1001582000465 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1001582000466 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1001582000467 elongation factor Tu; Reviewed; Region: PRK00049 1001582000468 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1001582000469 G1 box; other site 1001582000470 GEF interaction site [polypeptide binding]; other site 1001582000471 GTP/Mg2+ binding site [chemical binding]; other site 1001582000472 Switch I region; other site 1001582000473 G2 box; other site 1001582000474 G3 box; other site 1001582000475 Switch II region; other site 1001582000476 G4 box; other site 1001582000477 G5 box; other site 1001582000478 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1001582000479 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1001582000480 Antibiotic Binding Site [chemical binding]; other site 1001582000481 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1001582000482 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1001582000483 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1001582000484 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1001582000485 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1001582000486 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1001582000487 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1001582000488 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1001582000489 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1001582000490 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1001582000491 G-X-X-G motif; other site 1001582000492 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1001582000493 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1001582000494 L27 interface [polypeptide binding]; other site 1001582000495 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1001582000496 23S rRNA interface [nucleotide binding]; other site 1001582000497 putative translocon interaction site; other site 1001582000498 signal recognition particle (SRP54) interaction site; other site 1001582000499 L23 interface [polypeptide binding]; other site 1001582000500 trigger factor interaction site; other site 1001582000501 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1001582000502 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1001582000503 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1001582000504 RNA binding site [nucleotide binding]; other site 1001582000505 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1001582000506 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1001582000507 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1001582000508 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1001582000509 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1001582000510 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1001582000511 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1001582000512 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1001582000513 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1001582000514 23S rRNA interface [nucleotide binding]; other site 1001582000515 L5 interface [polypeptide binding]; other site 1001582000516 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1001582000517 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1001582000518 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1001582000519 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1001582000520 23S rRNA binding site [nucleotide binding]; other site 1001582000521 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1001582000522 preprotein translocase, SecY subunit; Region: 3a0501s007; TIGR00967 1001582000523 SecY translocase; Region: SecY; pfam00344 1001582000524 adenylate kinase; Reviewed; Region: adk; PRK00279 1001582000525 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1001582000526 AMP-binding site [chemical binding]; other site 1001582000527 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1001582000528 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1001582000529 active site 1001582000530 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1001582000531 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1001582000532 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1001582000533 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1001582000534 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1001582000535 alphaNTD homodimer interface [polypeptide binding]; other site 1001582000536 alphaNTD - beta interaction site [polypeptide binding]; other site 1001582000537 alphaNTD - beta' interaction site [polypeptide binding]; other site 1001582000538 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1001582000539 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1001582000540 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1001582000541 Walker A/P-loop; other site 1001582000542 ATP binding site [chemical binding]; other site 1001582000543 Q-loop/lid; other site 1001582000544 ABC transporter signature motif; other site 1001582000545 Walker B; other site 1001582000546 D-loop; other site 1001582000547 H-loop/switch region; other site 1001582000548 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1001582000549 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1001582000550 Walker A/P-loop; other site 1001582000551 ATP binding site [chemical binding]; other site 1001582000552 Q-loop/lid; other site 1001582000553 ABC transporter signature motif; other site 1001582000554 Walker B; other site 1001582000555 D-loop; other site 1001582000556 H-loop/switch region; other site 1001582000557 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1001582000558 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1001582000559 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1001582000560 dimerization interface 3.5A [polypeptide binding]; other site 1001582000561 active site 1001582000562 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1001582000563 23S rRNA interface [nucleotide binding]; other site 1001582000564 L3 interface [polypeptide binding]; other site 1001582000565 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1001582000566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582000567 S-adenosylmethionine binding site [chemical binding]; other site 1001582000568 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1001582000569 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1001582000570 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1001582000571 active site 1001582000572 metal binding site [ion binding]; metal-binding site 1001582000573 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1001582000574 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1001582000575 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1001582000576 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1001582000577 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1001582000578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582000579 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1001582000580 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1001582000581 inhibitor-cofactor binding pocket; inhibition site 1001582000582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582000583 catalytic residue [active] 1001582000584 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1001582000585 active site 1001582000586 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1001582000587 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1001582000588 NAD(P) binding site [chemical binding]; other site 1001582000589 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1001582000590 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1001582000591 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1001582000592 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1001582000593 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1001582000594 Sodium Bile acid symporter family; Region: SBF; cl17470 1001582000595 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1001582000596 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1001582000597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1001582000598 ABC-ATPase subunit interface; other site 1001582000599 dimer interface [polypeptide binding]; other site 1001582000600 putative PBP binding regions; other site 1001582000601 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1001582000602 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1001582000603 ABC-ATPase subunit interface; other site 1001582000604 dimer interface [polypeptide binding]; other site 1001582000605 putative PBP binding regions; other site 1001582000606 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1001582000607 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1001582000608 putative ligand binding residues [chemical binding]; other site 1001582000609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001582000610 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1001582000611 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001582000612 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1001582000613 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1001582000614 intersubunit interface [polypeptide binding]; other site 1001582000615 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 1001582000616 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1001582000617 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1001582000618 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1001582000619 putative periplasmic esterase; Provisional; Region: PRK03642 1001582000620 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1001582000621 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1001582000622 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1001582000623 active site turn [active] 1001582000624 phosphorylation site [posttranslational modification] 1001582000625 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1001582000626 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1001582000627 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1001582000628 putative active site [active] 1001582000629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1001582000630 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1001582000631 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1001582000632 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001582000633 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582000634 DNA binding residues [nucleotide binding] 1001582000635 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1001582000636 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1001582000637 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1001582000638 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1001582000639 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1001582000640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1001582000641 YbbR-like protein; Region: YbbR; pfam07949 1001582000642 YbbR-like protein; Region: YbbR; pfam07949 1001582000643 YbbR-like protein; Region: YbbR; pfam07949 1001582000644 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1001582000645 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1001582000646 active site 1001582000647 substrate binding site [chemical binding]; other site 1001582000648 metal binding site [ion binding]; metal-binding site 1001582000649 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1001582000650 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1001582000651 glutaminase active site [active] 1001582000652 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1001582000653 dimer interface [polypeptide binding]; other site 1001582000654 active site 1001582000655 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1001582000656 dimer interface [polypeptide binding]; other site 1001582000657 active site 1001582000658 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 1001582000659 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1001582000660 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001582000661 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001582000662 active site 1001582000663 catalytic tetrad [active] 1001582000664 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1001582000665 LrgA family; Region: LrgA; cl00608 1001582000666 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582000667 MarR family; Region: MarR; pfam01047 1001582000668 putative transport protein YifK; Provisional; Region: PRK10746 1001582000669 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1001582000670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582000671 active site 1001582000672 motif I; other site 1001582000673 motif II; other site 1001582000674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1001582000675 Histidine kinase; Region: HisKA_3; pfam07730 1001582000676 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1001582000677 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1001582000678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582000679 active site 1001582000680 phosphorylation site [posttranslational modification] 1001582000681 intermolecular recognition site; other site 1001582000682 dimerization interface [polypeptide binding]; other site 1001582000683 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1001582000684 DNA binding residues [nucleotide binding] 1001582000685 dimerization interface [polypeptide binding]; other site 1001582000686 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1001582000687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582000688 Walker A/P-loop; other site 1001582000689 ATP binding site [chemical binding]; other site 1001582000690 Q-loop/lid; other site 1001582000691 ABC transporter signature motif; other site 1001582000692 Walker B; other site 1001582000693 D-loop; other site 1001582000694 H-loop/switch region; other site 1001582000695 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1001582000696 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1001582000697 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1001582000698 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1001582000699 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1001582000700 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1001582000701 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1001582000702 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1001582000703 active site 1001582000704 catalytic site [active] 1001582000705 metal binding site [ion binding]; metal-binding site 1001582000706 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1001582000707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582000708 putative substrate translocation pore; other site 1001582000709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582000710 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1001582000711 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1001582000712 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1001582000713 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582000714 non-specific DNA binding site [nucleotide binding]; other site 1001582000715 salt bridge; other site 1001582000716 sequence-specific DNA binding site [nucleotide binding]; other site 1001582000717 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1001582000718 Glycerol_dehydrogenase-like; Region: GlyDH-like; cd08550 1001582000719 active site 1001582000720 NAD binding site [chemical binding]; other site 1001582000721 metal binding site [ion binding]; metal-binding site 1001582000722 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1001582000723 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1001582000724 ATP-grasp domain; Region: ATP-grasp; pfam02222 1001582000725 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1001582000726 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1001582000727 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1001582000728 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1001582000729 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1001582000730 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1001582000731 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1001582000732 active site residue [active] 1001582000733 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1001582000734 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1001582000735 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1001582000736 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1001582000737 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1001582000738 homodimer interface [polypeptide binding]; other site 1001582000739 substrate-cofactor binding pocket; other site 1001582000740 catalytic residue [active] 1001582000741 S-methylmethionine transporter; Provisional; Region: PRK11387 1001582000742 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1001582000743 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1001582000744 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1001582000745 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1001582000746 potential frameshift: common BLAST hit: gi|154684749|ref|YP_001419910.1| glutaminase 1001582000747 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1001582000748 glutaminase; Reviewed; Region: PRK12357 1001582000749 Glutaminase; Region: Glutaminase; cl00907 1001582000750 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001582000751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582000752 ATP binding site [chemical binding]; other site 1001582000753 Mg2+ binding site [ion binding]; other site 1001582000754 G-X-G motif; other site 1001582000755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582000756 Response regulator receiver domain; Region: Response_reg; pfam00072 1001582000757 active site 1001582000758 phosphorylation site [posttranslational modification] 1001582000759 intermolecular recognition site; other site 1001582000760 dimerization interface [polypeptide binding]; other site 1001582000761 YcbB domain; Region: YcbB; pfam08664 1001582000762 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1001582000763 putative active site [active] 1001582000764 putative substrate binding site [chemical binding]; other site 1001582000765 Phosphotransferase enzyme family; Region: APH; pfam01636 1001582000766 ATP binding site [chemical binding]; other site 1001582000767 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1001582000768 dodecamer interface 1 [polypeptide binding]; other site 1001582000769 dodecamer interface 2 [polypeptide binding]; other site 1001582000770 trimer interface [polypeptide binding]; other site 1001582000771 TRAP binding interface [polypeptide binding]; other site 1001582000772 Zn binding site [ion binding]; other site 1001582000773 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1001582000774 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1001582000775 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1001582000776 dimer interface [polypeptide binding]; other site 1001582000777 FMN binding site [chemical binding]; other site 1001582000778 Predicted membrane protein [Function unknown]; Region: COG2259 1001582000779 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001582000780 catalytic residues [active] 1001582000781 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1001582000782 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1001582000783 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1001582000784 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1001582000785 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1001582000786 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1001582000787 putative active site [active] 1001582000788 putative metal binding site [ion binding]; other site 1001582000789 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1001582000790 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1001582000791 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1001582000792 putative substrate binding pocket [chemical binding]; other site 1001582000793 AC domain interface; other site 1001582000794 catalytic triad [active] 1001582000795 AB domain interface; other site 1001582000796 interchain disulfide; other site 1001582000797 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1001582000798 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1001582000799 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001582000800 catalytic residue [active] 1001582000801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582000802 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582000803 putative substrate translocation pore; other site 1001582000804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582000805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582000806 potential frameshift: common BLAST hit: gi|375360932|ref|YP_005128971.1| triacylglycerol lipase 1001582000807 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1001582000808 potential frameshift: common BLAST hit: gi|375360932|ref|YP_005128971.1| triacylglycerol lipase 1001582000809 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1001582000810 PGAP1-like protein; Region: PGAP1; pfam07819 1001582000811 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1001582000812 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1001582000813 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001582000814 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001582000815 active site 1001582000816 catalytic tetrad [active] 1001582000817 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1001582000818 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1001582000819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582000820 binding surface 1001582000821 TPR motif; other site 1001582000822 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1001582000823 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582000824 TPR motif; other site 1001582000825 binding surface 1001582000826 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1001582000827 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1001582000828 NAD binding site [chemical binding]; other site 1001582000829 homodimer interface [polypeptide binding]; other site 1001582000830 active site 1001582000831 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1001582000832 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1001582000833 Ca binding site [ion binding]; other site 1001582000834 active site 1001582000835 catalytic site [active] 1001582000836 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 1001582000837 Predicted transcriptional regulators [Transcription]; Region: COG1695 1001582000838 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1001582000839 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1001582000840 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1001582000841 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1001582000842 metal binding site [ion binding]; metal-binding site 1001582000843 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1001582000844 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1001582000845 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1001582000846 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1001582000847 ABC-ATPase subunit interface; other site 1001582000848 dimer interface [polypeptide binding]; other site 1001582000849 putative PBP binding regions; other site 1001582000850 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1001582000851 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1001582000852 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1001582000853 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1001582000854 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1001582000855 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1001582000856 putative metal binding site [ion binding]; other site 1001582000857 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1001582000858 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1001582000859 putative metal binding site [ion binding]; other site 1001582000860 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1001582000861 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1001582000862 putative metal binding site [ion binding]; other site 1001582000863 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1001582000864 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1001582000865 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1001582000866 benzoate transport; Region: 2A0115; TIGR00895 1001582000867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582000868 putative substrate translocation pore; other site 1001582000869 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1001582000870 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1001582000871 Walker A/P-loop; other site 1001582000872 ATP binding site [chemical binding]; other site 1001582000873 Q-loop/lid; other site 1001582000874 ABC transporter signature motif; other site 1001582000875 Walker B; other site 1001582000876 D-loop; other site 1001582000877 H-loop/switch region; other site 1001582000878 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1001582000879 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1001582000880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582000881 dimer interface [polypeptide binding]; other site 1001582000882 conserved gate region; other site 1001582000883 putative PBP binding loops; other site 1001582000884 ABC-ATPase subunit interface; other site 1001582000885 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1001582000886 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1001582000887 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1001582000888 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1001582000889 amidohydrolase; Region: amidohydrolases; TIGR01891 1001582000890 metal binding site [ion binding]; metal-binding site 1001582000891 putative dimer interface [polypeptide binding]; other site 1001582000892 Predicted membrane protein [Function unknown]; Region: COG1288 1001582000893 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1001582000894 RDD family; Region: RDD; pfam06271 1001582000895 RDD family; Region: RDD; pfam06271 1001582000896 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1001582000897 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1001582000898 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1001582000899 NAD binding site [chemical binding]; other site 1001582000900 dimer interface [polypeptide binding]; other site 1001582000901 substrate binding site [chemical binding]; other site 1001582000902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582000903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582000904 putative substrate translocation pore; other site 1001582000905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582000906 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582000907 MarR family; Region: MarR; pfam01047 1001582000908 LysE type translocator; Region: LysE; pfam01810 1001582000909 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1001582000910 Spore germination protein; Region: Spore_permease; cl17796 1001582000911 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1001582000912 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1001582000913 homodimer interface [polypeptide binding]; other site 1001582000914 NAD binding pocket [chemical binding]; other site 1001582000915 ATP binding pocket [chemical binding]; other site 1001582000916 Mg binding site [ion binding]; other site 1001582000917 active-site loop [active] 1001582000918 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1001582000919 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1001582000920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582000921 D-galactonate transporter; Region: 2A0114; TIGR00893 1001582000922 putative substrate translocation pore; other site 1001582000923 shikimate kinase; Reviewed; Region: aroK; PRK00131 1001582000924 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1001582000925 ADP binding site [chemical binding]; other site 1001582000926 magnesium binding site [ion binding]; other site 1001582000927 putative shikimate binding site; other site 1001582000928 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1001582000929 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1001582000930 Proline dehydrogenase; Region: Pro_dh; pfam01619 1001582000931 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1001582000932 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1001582000933 Glutamate binding site [chemical binding]; other site 1001582000934 homodimer interface [polypeptide binding]; other site 1001582000935 NAD binding site [chemical binding]; other site 1001582000936 catalytic residues [active] 1001582000937 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1001582000938 Na binding site [ion binding]; other site 1001582000939 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1001582000940 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1001582000941 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1001582000942 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001582000943 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001582000944 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1001582000945 active site 1001582000946 SAM binding site [chemical binding]; other site 1001582000947 homodimer interface [polypeptide binding]; other site 1001582000948 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1001582000949 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1001582000950 [2Fe-2S] cluster binding site [ion binding]; other site 1001582000951 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1001582000952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001582000953 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1001582000954 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1001582000955 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1001582000956 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1001582000957 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1001582000958 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1001582000959 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1001582000960 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1001582000961 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1001582000962 NAD binding site [chemical binding]; other site 1001582000963 catalytic Zn binding site [ion binding]; other site 1001582000964 structural Zn binding site [ion binding]; other site 1001582000965 RDD family; Region: RDD; pfam06271 1001582000966 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1001582000967 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1001582000968 beta-galactosidase; Region: BGL; TIGR03356 1001582000969 Competence protein J (ComJ); Region: ComJ; pfam11033 1001582000970 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1001582000971 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1001582000972 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1001582000973 tetramer interface [polypeptide binding]; other site 1001582000974 active site 1001582000975 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1001582000976 active site 1001582000977 dimer interface [polypeptide binding]; other site 1001582000978 magnesium binding site [ion binding]; other site 1001582000979 Predicted transcriptional regulators [Transcription]; Region: COG1733 1001582000980 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1001582000981 Condensation domain; Region: Condensation; pfam00668 1001582000982 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582000983 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1001582000984 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1001582000985 acyl-activating enzyme (AAE) consensus motif; other site 1001582000986 AMP binding site [chemical binding]; other site 1001582000987 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582000988 Condensation domain; Region: Condensation; pfam00668 1001582000989 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582000990 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1001582000991 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1001582000992 acyl-activating enzyme (AAE) consensus motif; other site 1001582000993 AMP binding site [chemical binding]; other site 1001582000994 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582000995 Condensation domain; Region: Condensation; pfam00668 1001582000996 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582000997 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1001582000998 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1001582000999 acyl-activating enzyme (AAE) consensus motif; other site 1001582001000 AMP binding site [chemical binding]; other site 1001582001001 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582001002 Condensation domain; Region: Condensation; pfam00668 1001582001003 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1001582001004 Condensation domain; Region: Condensation; pfam00668 1001582001005 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582001006 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1001582001007 acyl-activating enzyme (AAE) consensus motif; other site 1001582001008 AMP binding site [chemical binding]; other site 1001582001009 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582001010 Condensation domain; Region: Condensation; pfam00668 1001582001011 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582001012 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1001582001013 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1001582001014 acyl-activating enzyme (AAE) consensus motif; other site 1001582001015 AMP binding site [chemical binding]; other site 1001582001016 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582001017 Condensation domain; Region: Condensation; pfam00668 1001582001018 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582001019 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1001582001020 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1001582001021 acyl-activating enzyme (AAE) consensus motif; other site 1001582001022 AMP binding site [chemical binding]; other site 1001582001023 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582001024 Condensation domain; Region: Condensation; pfam00668 1001582001025 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582001026 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1001582001027 Condensation domain; Region: Condensation; pfam00668 1001582001028 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582001029 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1001582001030 acyl-activating enzyme (AAE) consensus motif; other site 1001582001031 AMP binding site [chemical binding]; other site 1001582001032 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582001033 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1001582001034 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1001582001035 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 1001582001036 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1001582001037 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 1001582001038 Predicted membrane protein [Function unknown]; Region: COG2364 1001582001039 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001582001040 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001582001041 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1001582001042 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1001582001043 Walker A/P-loop; other site 1001582001044 ATP binding site [chemical binding]; other site 1001582001045 Q-loop/lid; other site 1001582001046 ABC transporter signature motif; other site 1001582001047 Walker B; other site 1001582001048 D-loop; other site 1001582001049 H-loop/switch region; other site 1001582001050 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1001582001051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582001052 dimer interface [polypeptide binding]; other site 1001582001053 conserved gate region; other site 1001582001054 putative PBP binding loops; other site 1001582001055 ABC-ATPase subunit interface; other site 1001582001056 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1001582001057 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1001582001058 substrate binding pocket [chemical binding]; other site 1001582001059 membrane-bound complex binding site; other site 1001582001060 hinge residues; other site 1001582001061 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001582001062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001582001063 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1001582001064 dimerization interface [polypeptide binding]; other site 1001582001065 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1001582001066 Flavoprotein; Region: Flavoprotein; pfam02441 1001582001067 UbiD family decarboxylase; Region: TIGR00148 1001582001068 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1001582001069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582001070 putative substrate translocation pore; other site 1001582001071 POT family; Region: PTR2; pfam00854 1001582001072 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1001582001073 Right handed beta helix region; Region: Beta_helix; pfam13229 1001582001074 Right handed beta helix region; Region: Beta_helix; pfam13229 1001582001075 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1001582001076 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1001582001077 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1001582001078 Spore germination protein; Region: Spore_permease; pfam03845 1001582001079 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1001582001080 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1001582001081 active site 1001582001082 non-prolyl cis peptide bond; other site 1001582001083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582001084 Coenzyme A binding pocket [chemical binding]; other site 1001582001085 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1001582001086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1001582001087 substrate binding pocket [chemical binding]; other site 1001582001088 membrane-bound complex binding site; other site 1001582001089 hinge residues; other site 1001582001090 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1001582001091 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1001582001092 Walker A/P-loop; other site 1001582001093 ATP binding site [chemical binding]; other site 1001582001094 Q-loop/lid; other site 1001582001095 ABC transporter signature motif; other site 1001582001096 Walker B; other site 1001582001097 D-loop; other site 1001582001098 H-loop/switch region; other site 1001582001099 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1001582001100 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1001582001101 metal binding site [ion binding]; metal-binding site 1001582001102 dimer interface [polypeptide binding]; other site 1001582001103 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1001582001104 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1001582001105 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1001582001106 Walker A/P-loop; other site 1001582001107 ATP binding site [chemical binding]; other site 1001582001108 Q-loop/lid; other site 1001582001109 ABC transporter signature motif; other site 1001582001110 Walker B; other site 1001582001111 D-loop; other site 1001582001112 H-loop/switch region; other site 1001582001113 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1001582001114 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1001582001115 FtsX-like permease family; Region: FtsX; pfam02687 1001582001116 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001582001117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582001118 active site 1001582001119 phosphorylation site [posttranslational modification] 1001582001120 intermolecular recognition site; other site 1001582001121 dimerization interface [polypeptide binding]; other site 1001582001122 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001582001123 DNA binding site [nucleotide binding] 1001582001124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001582001125 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1001582001126 dimerization interface [polypeptide binding]; other site 1001582001127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582001128 dimer interface [polypeptide binding]; other site 1001582001129 phosphorylation site [posttranslational modification] 1001582001130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582001131 ATP binding site [chemical binding]; other site 1001582001132 Mg2+ binding site [ion binding]; other site 1001582001133 G-X-G motif; other site 1001582001134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1001582001135 binding surface 1001582001136 TPR motif; other site 1001582001137 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582001138 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582001139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582001140 TPR motif; other site 1001582001141 binding surface 1001582001142 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582001143 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1001582001144 aspartate kinase; Reviewed; Region: PRK09034 1001582001145 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1001582001146 putative catalytic residues [active] 1001582001147 putative nucleotide binding site [chemical binding]; other site 1001582001148 putative aspartate binding site [chemical binding]; other site 1001582001149 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1001582001150 allosteric regulatory residue; other site 1001582001151 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1001582001152 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1001582001153 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1001582001154 ABC-ATPase subunit interface; other site 1001582001155 dimer interface [polypeptide binding]; other site 1001582001156 putative PBP binding regions; other site 1001582001157 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1001582001158 ABC-ATPase subunit interface; other site 1001582001159 dimer interface [polypeptide binding]; other site 1001582001160 putative PBP binding regions; other site 1001582001161 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1001582001162 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1001582001163 Walker A/P-loop; other site 1001582001164 ATP binding site [chemical binding]; other site 1001582001165 Q-loop/lid; other site 1001582001166 ABC transporter signature motif; other site 1001582001167 Walker B; other site 1001582001168 D-loop; other site 1001582001169 H-loop/switch region; other site 1001582001170 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1001582001171 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1001582001172 putative ligand binding residues [chemical binding]; other site 1001582001173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582001174 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582001175 putative substrate translocation pore; other site 1001582001176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582001177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582001178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582001179 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1001582001180 dimer interface [polypeptide binding]; other site 1001582001181 FMN binding site [chemical binding]; other site 1001582001182 NADPH bind site [chemical binding]; other site 1001582001183 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1001582001184 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582001185 dimerization interface [polypeptide binding]; other site 1001582001186 putative DNA binding site [nucleotide binding]; other site 1001582001187 putative Zn2+ binding site [ion binding]; other site 1001582001188 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1001582001189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582001190 DNA-binding site [nucleotide binding]; DNA binding site 1001582001191 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001582001192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582001193 homodimer interface [polypeptide binding]; other site 1001582001194 catalytic residue [active] 1001582001195 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1001582001196 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1001582001197 inhibitor-cofactor binding pocket; inhibition site 1001582001198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582001199 catalytic residue [active] 1001582001200 succinic semialdehyde dehydrogenase; Region: PLN02278 1001582001201 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1001582001202 tetramerization interface [polypeptide binding]; other site 1001582001203 NAD(P) binding site [chemical binding]; other site 1001582001204 catalytic residues [active] 1001582001205 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1001582001206 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1001582001207 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1001582001208 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1001582001209 NAD binding site [chemical binding]; other site 1001582001210 homodimer interface [polypeptide binding]; other site 1001582001211 active site 1001582001212 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1001582001213 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1001582001214 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1001582001215 YtkA-like; Region: YtkA; pfam13115 1001582001216 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1001582001217 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1001582001218 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1001582001219 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1001582001220 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1001582001221 active site 1001582001222 P-loop; other site 1001582001223 phosphorylation site [posttranslational modification] 1001582001224 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1001582001225 active site 1001582001226 phosphorylation site [posttranslational modification] 1001582001227 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1001582001228 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1001582001229 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1001582001230 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1001582001231 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1001582001232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582001233 active site 1001582001234 motif I; other site 1001582001235 motif II; other site 1001582001236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582001237 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1001582001238 putative active site [active] 1001582001239 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1001582001240 hypothetical protein; Provisional; Region: PRK05463 1001582001241 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1001582001242 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1001582001243 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1001582001244 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1001582001245 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1001582001246 Bacterial transcriptional regulator; Region: IclR; pfam01614 1001582001247 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1001582001248 active site 1001582001249 catalytic triad [active] 1001582001250 oxyanion hole [active] 1001582001251 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1001582001252 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1001582001253 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1001582001254 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1001582001255 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1001582001256 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1001582001257 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001582001258 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001582001259 active site 1001582001260 catalytic tetrad [active] 1001582001261 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1001582001262 HTH domain; Region: HTH_11; pfam08279 1001582001263 HTH domain; Region: HTH_11; cl17392 1001582001264 PRD domain; Region: PRD; pfam00874 1001582001265 PRD domain; Region: PRD; pfam00874 1001582001266 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1001582001267 active site 1001582001268 P-loop; other site 1001582001269 phosphorylation site [posttranslational modification] 1001582001270 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1001582001271 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1001582001272 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1001582001273 acyl-activating enzyme (AAE) consensus motif; other site 1001582001274 putative AMP binding site [chemical binding]; other site 1001582001275 putative active site [active] 1001582001276 putative CoA binding site [chemical binding]; other site 1001582001277 short chain dehydrogenase; Provisional; Region: PRK06701 1001582001278 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1001582001279 NAD binding site [chemical binding]; other site 1001582001280 metal binding site [ion binding]; metal-binding site 1001582001281 active site 1001582001282 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1001582001283 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1001582001284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1001582001285 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1001582001286 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1001582001287 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1001582001288 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1001582001289 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1001582001290 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1001582001291 putative DNA binding site [nucleotide binding]; other site 1001582001292 putative Zn2+ binding site [ion binding]; other site 1001582001293 AsnC family; Region: AsnC_trans_reg; pfam01037 1001582001294 DNA topoisomerase III; Provisional; Region: PRK07726 1001582001295 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1001582001296 active site 1001582001297 putative interdomain interaction site [polypeptide binding]; other site 1001582001298 putative metal-binding site [ion binding]; other site 1001582001299 putative nucleotide binding site [chemical binding]; other site 1001582001300 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1001582001301 domain I; other site 1001582001302 DNA binding groove [nucleotide binding] 1001582001303 phosphate binding site [ion binding]; other site 1001582001304 domain II; other site 1001582001305 domain III; other site 1001582001306 nucleotide binding site [chemical binding]; other site 1001582001307 catalytic site [active] 1001582001308 domain IV; other site 1001582001309 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1001582001310 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1001582001311 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1001582001312 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1001582001313 metal binding site [ion binding]; metal-binding site 1001582001314 active site 1001582001315 I-site; other site 1001582001316 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1001582001317 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1001582001318 NodB motif; other site 1001582001319 putative active site [active] 1001582001320 putative catalytic site [active] 1001582001321 putative Zn binding site [ion binding]; other site 1001582001322 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1001582001323 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1001582001324 DXD motif; other site 1001582001325 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1001582001326 Amino acid permease; Region: AA_permease_2; pfam13520 1001582001327 pyruvate oxidase; Provisional; Region: PRK08611 1001582001328 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1001582001329 PYR/PP interface [polypeptide binding]; other site 1001582001330 dimer interface [polypeptide binding]; other site 1001582001331 tetramer interface [polypeptide binding]; other site 1001582001332 TPP binding site [chemical binding]; other site 1001582001333 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1001582001334 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1001582001335 TPP-binding site [chemical binding]; other site 1001582001336 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1001582001337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582001338 Coenzyme A binding pocket [chemical binding]; other site 1001582001339 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1001582001340 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1001582001341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1001582001342 binding surface 1001582001343 TPR motif; other site 1001582001344 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582001345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1001582001346 TPR motif; other site 1001582001347 binding surface 1001582001348 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582001349 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1001582001350 manganese transport protein MntH; Reviewed; Region: PRK00701 1001582001351 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1001582001352 Bacterial SH3 domain; Region: SH3_3; cl17532 1001582001353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1001582001354 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1001582001355 EcsC protein family; Region: EcsC; pfam12787 1001582001356 General stress protein [General function prediction only]; Region: GsiB; COG3729 1001582001357 General stress protein [General function prediction only]; Region: GsiB; COG3729 1001582001358 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1001582001359 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1001582001360 dimanganese center [ion binding]; other site 1001582001361 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1001582001362 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1001582001363 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1001582001364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1001582001365 putative active site [active] 1001582001366 heme pocket [chemical binding]; other site 1001582001367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582001368 ATP binding site [chemical binding]; other site 1001582001369 Mg2+ binding site [ion binding]; other site 1001582001370 G-X-G motif; other site 1001582001371 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1001582001372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582001373 active site 1001582001374 phosphorylation site [posttranslational modification] 1001582001375 intermolecular recognition site; other site 1001582001376 dimerization interface [polypeptide binding]; other site 1001582001377 HTH domain; Region: HTH_11; pfam08279 1001582001378 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1001582001379 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1001582001380 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1001582001381 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1001582001382 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1001582001383 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582001384 Walker A/P-loop; other site 1001582001385 ATP binding site [chemical binding]; other site 1001582001386 Q-loop/lid; other site 1001582001387 ABC transporter signature motif; other site 1001582001388 Walker B; other site 1001582001389 D-loop; other site 1001582001390 H-loop/switch region; other site 1001582001391 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1001582001392 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1001582001393 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1001582001394 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1001582001395 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1001582001396 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001582001397 catalytic residues [active] 1001582001398 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1001582001399 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1001582001400 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1001582001401 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1001582001402 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1001582001403 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001582001404 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001582001405 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1001582001406 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1001582001407 ATP binding site [chemical binding]; other site 1001582001408 Mg++ binding site [ion binding]; other site 1001582001409 motif III; other site 1001582001410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001582001411 nucleotide binding region [chemical binding]; other site 1001582001412 ATP-binding site [chemical binding]; other site 1001582001413 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1001582001414 Predicted membrane protein [Function unknown]; Region: COG3428 1001582001415 Bacterial PH domain; Region: DUF304; pfam03703 1001582001416 Bacterial PH domain; Region: DUF304; pfam03703 1001582001417 Bacterial PH domain; Region: DUF304; pfam03703 1001582001418 Rhomboid family; Region: Rhomboid; pfam01694 1001582001419 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1001582001420 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1001582001421 alanine racemase; Region: alr; TIGR00492 1001582001422 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1001582001423 active site 1001582001424 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1001582001425 dimer interface [polypeptide binding]; other site 1001582001426 substrate binding site [chemical binding]; other site 1001582001427 catalytic residues [active] 1001582001428 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1001582001429 ribbon-helix-helix domain containing protein; Region: PHA00617 1001582001430 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1001582001431 Rsbr N terminal; Region: Rsbr_N; pfam08678 1001582001432 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1001582001433 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1001582001434 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1001582001435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582001436 ATP binding site [chemical binding]; other site 1001582001437 Mg2+ binding site [ion binding]; other site 1001582001438 G-X-G motif; other site 1001582001439 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1001582001440 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1001582001441 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1001582001442 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1001582001443 anti sigma factor interaction site; other site 1001582001444 regulatory phosphorylation site [posttranslational modification]; other site 1001582001445 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1001582001446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582001447 ATP binding site [chemical binding]; other site 1001582001448 Mg2+ binding site [ion binding]; other site 1001582001449 G-X-G motif; other site 1001582001450 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1001582001451 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001582001452 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1001582001453 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582001454 DNA binding residues [nucleotide binding] 1001582001455 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1001582001456 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1001582001457 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1001582001458 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1001582001459 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1001582001460 RNA binding site [nucleotide binding]; other site 1001582001461 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1001582001462 hypothetical protein; Provisional; Region: PRK04351 1001582001463 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1001582001464 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1001582001465 substrate binding pocket [chemical binding]; other site 1001582001466 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1001582001467 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1001582001468 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1001582001469 MarR family; Region: MarR; pfam01047 1001582001470 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 1001582001471 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1001582001472 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1001582001473 DNA-binding site [nucleotide binding]; DNA binding site 1001582001474 RNA-binding motif; other site 1001582001475 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1001582001476 aspartate racemase; Region: asp_race; TIGR00035 1001582001477 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1001582001478 Predicted transcriptional regulators [Transcription]; Region: COG1695 1001582001479 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1001582001480 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1001582001481 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582001482 DNA-binding site [nucleotide binding]; DNA binding site 1001582001483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001582001484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582001485 homodimer interface [polypeptide binding]; other site 1001582001486 catalytic residue [active] 1001582001487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582001488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582001489 putative substrate translocation pore; other site 1001582001490 Patatin [General function prediction only]; Region: COG3621 1001582001491 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 1001582001492 active site 1001582001493 nucleophile elbow; other site 1001582001494 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1001582001495 FAD binding domain; Region: FAD_binding_4; pfam01565 1001582001496 Berberine and berberine like; Region: BBE; pfam08031 1001582001497 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1001582001498 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1001582001499 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1001582001500 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1001582001501 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1001582001502 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1001582001503 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1001582001504 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1001582001505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582001506 Coenzyme A binding pocket [chemical binding]; other site 1001582001507 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1001582001508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1001582001509 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 1001582001510 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001582001511 FeS/SAM binding site; other site 1001582001512 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1001582001513 Sodium Bile acid symporter family; Region: SBF; cl17470 1001582001514 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1001582001515 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1001582001516 putative NAD(P) binding site [chemical binding]; other site 1001582001517 putative substrate binding site [chemical binding]; other site 1001582001518 catalytic Zn binding site [ion binding]; other site 1001582001519 structural Zn binding site [ion binding]; other site 1001582001520 dimer interface [polypeptide binding]; other site 1001582001521 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1001582001522 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1001582001523 DNA binding residues [nucleotide binding] 1001582001524 putative dimer interface [polypeptide binding]; other site 1001582001525 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1001582001526 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1001582001527 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582001528 DNA-binding site [nucleotide binding]; DNA binding site 1001582001529 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001582001530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582001531 homodimer interface [polypeptide binding]; other site 1001582001532 catalytic residue [active] 1001582001533 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1001582001534 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1001582001535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582001536 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582001537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582001538 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1001582001539 EamA-like transporter family; Region: EamA; cl17759 1001582001540 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1001582001541 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582001542 DNA-binding site [nucleotide binding]; DNA binding site 1001582001543 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001582001544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582001545 homodimer interface [polypeptide binding]; other site 1001582001546 catalytic residue [active] 1001582001547 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1001582001548 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1001582001549 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1001582001550 NAD binding site [chemical binding]; other site 1001582001551 catalytic Zn binding site [ion binding]; other site 1001582001552 structural Zn binding site [ion binding]; other site 1001582001553 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1001582001554 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1001582001555 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1001582001556 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1001582001557 catalytic triad [active] 1001582001558 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1001582001559 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001582001560 ABC transporter; Region: ABC_tran_2; pfam12848 1001582001561 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001582001562 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1001582001563 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582001564 Coenzyme A binding pocket [chemical binding]; other site 1001582001565 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1001582001566 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001582001567 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001582001568 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1001582001569 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1001582001570 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1001582001571 dimer interface [polypeptide binding]; other site 1001582001572 active site 1001582001573 metal binding site [ion binding]; metal-binding site 1001582001574 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1001582001575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582001576 putative substrate translocation pore; other site 1001582001577 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1001582001578 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1001582001579 dimer interface [polypeptide binding]; other site 1001582001580 active site 1001582001581 Helix-turn-helix domain; Region: HTH_31; pfam13560 1001582001582 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1001582001583 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582001584 Coenzyme A binding pocket [chemical binding]; other site 1001582001585 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1001582001586 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1001582001587 DNA binding residues [nucleotide binding] 1001582001588 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1001582001589 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1001582001590 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1001582001591 nudix motif; other site 1001582001592 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1001582001593 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1001582001594 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1001582001595 tartrate dehydrogenase; Provisional; Region: PRK08194 1001582001596 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1001582001597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582001598 DNA-binding site [nucleotide binding]; DNA binding site 1001582001599 FCD domain; Region: FCD; pfam07729 1001582001600 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1001582001601 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1001582001602 active site 1001582001603 TDP-binding site; other site 1001582001604 acceptor substrate-binding pocket; other site 1001582001605 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1001582001606 Beta-lactamase; Region: Beta-lactamase; pfam00144 1001582001607 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1001582001608 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1001582001609 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1001582001610 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1001582001611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582001612 putative substrate translocation pore; other site 1001582001613 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1001582001614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582001615 DNA-binding site [nucleotide binding]; DNA binding site 1001582001616 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1001582001617 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1001582001618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582001619 DNA-binding site [nucleotide binding]; DNA binding site 1001582001620 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1001582001621 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1001582001622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582001623 putative substrate translocation pore; other site 1001582001624 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1001582001625 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1001582001626 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582001627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582001628 amino acid transporter; Region: 2A0306; TIGR00909 1001582001629 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1001582001630 dimanganese center [ion binding]; other site 1001582001631 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1001582001632 putative hydrophobic ligand binding site [chemical binding]; other site 1001582001633 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1001582001634 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1001582001635 putative NADP binding site [chemical binding]; other site 1001582001636 putative dimer interface [polypeptide binding]; other site 1001582001637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582001638 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1001582001639 putative substrate translocation pore; other site 1001582001640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582001641 thiamine monophosphate kinase; Provisional; Region: PRK05731 1001582001642 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1001582001643 ATP binding site [chemical binding]; other site 1001582001644 dimerization interface [polypeptide binding]; other site 1001582001645 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1001582001646 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1001582001647 Glycoprotease family; Region: Peptidase_M22; pfam00814 1001582001648 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1001582001649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582001650 Coenzyme A binding pocket [chemical binding]; other site 1001582001651 UGMP family protein; Validated; Region: PRK09604 1001582001652 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1001582001653 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1001582001654 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1001582001655 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001582001656 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001582001657 ABC transporter; Region: ABC_tran_2; pfam12848 1001582001658 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001582001659 ABC transporter; Region: ABC_tran_2; pfam12848 1001582001660 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1001582001661 trimer interface [polypeptide binding]; other site 1001582001662 dimer interface [polypeptide binding]; other site 1001582001663 putative active site [active] 1001582001664 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1001582001665 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1001582001666 CoA binding domain; Region: CoA_binding; pfam02629 1001582001667 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1001582001668 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1001582001669 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1001582001670 CAAX protease self-immunity; Region: Abi; pfam02517 1001582001671 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1001582001672 oligomerisation interface [polypeptide binding]; other site 1001582001673 mobile loop; other site 1001582001674 roof hairpin; other site 1001582001675 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1001582001676 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1001582001677 ring oligomerisation interface [polypeptide binding]; other site 1001582001678 ATP/Mg binding site [chemical binding]; other site 1001582001679 stacking interactions; other site 1001582001680 hinge regions; other site 1001582001681 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1001582001682 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1001582001683 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1001582001684 active site 1001582001685 DNA binding site [nucleotide binding] 1001582001686 Int/Topo IB signature motif; other site 1001582001687 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001582001688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582001689 non-specific DNA binding site [nucleotide binding]; other site 1001582001690 salt bridge; other site 1001582001691 sequence-specific DNA binding site [nucleotide binding]; other site 1001582001692 BRO family, N-terminal domain; Region: Bro-N; cl10591 1001582001693 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1001582001694 Hypothetical protein Yqai; Region: Yqai; pfam09466 1001582001695 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1001582001696 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 1001582001697 Helix-turn-helix domain; Region: HTH_36; pfam13730 1001582001698 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1001582001699 hypothetical protein; Provisional; Region: PRK06921 1001582001700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582001701 Walker A motif; other site 1001582001702 ATP binding site [chemical binding]; other site 1001582001703 Walker B motif; other site 1001582001704 arginine finger; other site 1001582001705 YopX protein; Region: YopX; pfam09643 1001582001706 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1001582001707 Helix-turn-helix domain; Region: HTH_17; cl17695 1001582001708 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1001582001709 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1001582001710 cofactor binding site; other site 1001582001711 DNA binding site [nucleotide binding] 1001582001712 substrate interaction site [chemical binding]; other site 1001582001713 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1001582001714 dUTPase; Region: dUTPase_2; pfam08761 1001582001715 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1001582001716 active site 1001582001717 homodimer interface [polypeptide binding]; other site 1001582001718 metal binding site [ion binding]; metal-binding site 1001582001719 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1001582001720 YopX protein; Region: YopX; cl09859 1001582001721 positive control sigma-like factor; Validated; Region: PRK06930 1001582001722 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582001723 DNA binding residues [nucleotide binding] 1001582001724 Helix-turn-helix domain; Region: HTH_17; pfam12728 1001582001725 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1001582001726 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1001582001727 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1001582001728 Phage terminase large subunit; Region: Terminase_3; cl12054 1001582001729 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1001582001730 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1001582001731 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1001582001732 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 1001582001733 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1001582001734 Interdomain contacts; other site 1001582001735 Cytokine receptor motif; other site 1001582001736 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1001582001737 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 1001582001738 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1001582001739 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1001582001740 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1001582001741 Phage major tail protein 2; Region: Phage_tail_2; cl11463 1001582001742 Phage protein; Region: DUF3647; pfam12363 1001582001743 Phage-related protein [Function unknown]; Region: COG5412 1001582001744 Phage tail protein; Region: Sipho_tail; pfam05709 1001582001745 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1001582001746 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1001582001747 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1001582001748 amidase catalytic site [active] 1001582001749 Zn binding residues [ion binding]; other site 1001582001750 substrate binding site [chemical binding]; other site 1001582001751 Bacterial SH3 domain; Region: SH3_3; cl17532 1001582001752 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1001582001753 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1001582001754 Abi-like protein; Region: Abi_2; cl01988 1001582001755 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1001582001756 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1001582001757 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1001582001758 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1001582001759 active site 1001582001760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582001761 Walker A motif; other site 1001582001762 ATP binding site [chemical binding]; other site 1001582001763 Walker B motif; other site 1001582001764 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582001765 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582001766 binding surface 1001582001767 TPR motif; other site 1001582001768 TPR repeat; Region: TPR_11; pfam13414 1001582001769 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1001582001770 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1001582001771 inhibitor binding site; inhibition site 1001582001772 catalytic Zn binding site [ion binding]; other site 1001582001773 structural Zn binding site [ion binding]; other site 1001582001774 NADP binding site [chemical binding]; other site 1001582001775 tetramer interface [polypeptide binding]; other site 1001582001776 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1001582001777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582001778 putative substrate translocation pore; other site 1001582001779 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1001582001780 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1001582001781 putative substrate binding site [chemical binding]; other site 1001582001782 putative ATP binding site [chemical binding]; other site 1001582001783 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1001582001784 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1001582001785 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 1001582001786 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1001582001787 Repair protein; Region: Repair_PSII; pfam04536 1001582001788 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1001582001789 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1001582001790 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1001582001791 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1001582001792 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1001582001793 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1001582001794 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1001582001795 catalytic triad [active] 1001582001796 catalytic triad [active] 1001582001797 oxyanion hole [active] 1001582001798 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1001582001799 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1001582001800 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1001582001801 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001582001802 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582001803 DNA binding residues [nucleotide binding] 1001582001804 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1001582001805 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1001582001806 putative NAD(P) binding site [chemical binding]; other site 1001582001807 catalytic Zn binding site [ion binding]; other site 1001582001808 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1001582001809 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1001582001810 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1001582001811 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1001582001812 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1001582001813 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1001582001814 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1001582001815 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1001582001816 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1001582001817 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1001582001818 MoxR-like ATPases [General function prediction only]; Region: COG0714 1001582001819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582001820 Walker A motif; other site 1001582001821 ATP binding site [chemical binding]; other site 1001582001822 Walker B motif; other site 1001582001823 arginine finger; other site 1001582001824 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1001582001825 Protein of unknown function DUF58; Region: DUF58; pfam01882 1001582001826 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1001582001827 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1001582001828 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1001582001829 GMP synthase; Reviewed; Region: guaA; PRK00074 1001582001830 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1001582001831 AMP/PPi binding site [chemical binding]; other site 1001582001832 candidate oxyanion hole; other site 1001582001833 catalytic triad [active] 1001582001834 potential glutamine specificity residues [chemical binding]; other site 1001582001835 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1001582001836 ATP Binding subdomain [chemical binding]; other site 1001582001837 Ligand Binding sites [chemical binding]; other site 1001582001838 Dimerization subdomain; other site 1001582001839 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1001582001840 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001582001841 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582001842 DNA binding residues [nucleotide binding] 1001582001843 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1001582001844 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1001582001845 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1001582001846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1001582001847 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1001582001848 NETI protein; Region: NETI; pfam14044 1001582001849 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1001582001850 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1001582001851 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1001582001852 NAD binding site [chemical binding]; other site 1001582001853 ATP-grasp domain; Region: ATP-grasp; pfam02222 1001582001854 adenylosuccinate lyase; Provisional; Region: PRK07492 1001582001855 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1001582001856 tetramer interface [polypeptide binding]; other site 1001582001857 active site 1001582001858 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1001582001859 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1001582001860 ATP binding site [chemical binding]; other site 1001582001861 active site 1001582001862 substrate binding site [chemical binding]; other site 1001582001863 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1001582001864 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1001582001865 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1001582001866 putative active site [active] 1001582001867 catalytic triad [active] 1001582001868 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1001582001869 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1001582001870 dimerization interface [polypeptide binding]; other site 1001582001871 ATP binding site [chemical binding]; other site 1001582001872 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1001582001873 dimerization interface [polypeptide binding]; other site 1001582001874 ATP binding site [chemical binding]; other site 1001582001875 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1001582001876 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1001582001877 active site 1001582001878 tetramer interface [polypeptide binding]; other site 1001582001879 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001582001880 active site 1001582001881 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1001582001882 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1001582001883 dimerization interface [polypeptide binding]; other site 1001582001884 putative ATP binding site [chemical binding]; other site 1001582001885 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1001582001886 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1001582001887 active site 1001582001888 substrate binding site [chemical binding]; other site 1001582001889 cosubstrate binding site; other site 1001582001890 catalytic site [active] 1001582001891 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1001582001892 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1001582001893 purine monophosphate binding site [chemical binding]; other site 1001582001894 dimer interface [polypeptide binding]; other site 1001582001895 putative catalytic residues [active] 1001582001896 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1001582001897 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1001582001898 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1001582001899 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1001582001900 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1001582001901 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1001582001902 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1001582001903 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582001904 putative DNA binding site [nucleotide binding]; other site 1001582001905 putative Zn2+ binding site [ion binding]; other site 1001582001906 AsnC family; Region: AsnC_trans_reg; pfam01037 1001582001907 putative transporter; Provisional; Region: PRK11021 1001582001908 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1001582001909 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1001582001910 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1001582001911 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1001582001912 active site 1001582001913 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1001582001914 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1001582001915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1001582001916 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1001582001917 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1001582001918 active site 1001582001919 FMN binding site [chemical binding]; other site 1001582001920 substrate binding site [chemical binding]; other site 1001582001921 3Fe-4S cluster binding site [ion binding]; other site 1001582001922 PcrB family; Region: PcrB; pfam01884 1001582001923 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1001582001924 substrate binding site [chemical binding]; other site 1001582001925 putative active site [active] 1001582001926 dimer interface [polypeptide binding]; other site 1001582001927 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1001582001928 Part of AAA domain; Region: AAA_19; pfam13245 1001582001929 Family description; Region: UvrD_C_2; pfam13538 1001582001930 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1001582001931 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1001582001932 nucleotide binding pocket [chemical binding]; other site 1001582001933 K-X-D-G motif; other site 1001582001934 catalytic site [active] 1001582001935 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1001582001936 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1001582001937 Helix-hairpin-helix motif; Region: HHH; pfam00633 1001582001938 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1001582001939 Dimer interface [polypeptide binding]; other site 1001582001940 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1001582001941 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1001582001942 putative dimer interface [polypeptide binding]; other site 1001582001943 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1001582001944 putative dimer interface [polypeptide binding]; other site 1001582001945 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1001582001946 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1001582001947 active site 1001582001948 ATP binding site [chemical binding]; other site 1001582001949 substrate binding site [chemical binding]; other site 1001582001950 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1001582001951 MgtC family; Region: MgtC; pfam02308 1001582001952 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1001582001953 Na binding site [ion binding]; other site 1001582001954 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1001582001955 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1001582001956 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1001582001957 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1001582001958 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1001582001959 GatB domain; Region: GatB_Yqey; pfam02637 1001582001960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582001961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582001962 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1001582001963 Protein export membrane protein; Region: SecD_SecF; cl14618 1001582001964 putative lipid kinase; Reviewed; Region: PRK13337 1001582001965 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1001582001966 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1001582001967 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1001582001968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582001969 S-adenosylmethionine binding site [chemical binding]; other site 1001582001970 Part of AAA domain; Region: AAA_19; pfam13245 1001582001971 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1001582001972 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1001582001973 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1001582001974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582001975 Walker A/P-loop; other site 1001582001976 ATP binding site [chemical binding]; other site 1001582001977 Q-loop/lid; other site 1001582001978 ABC transporter signature motif; other site 1001582001979 Walker B; other site 1001582001980 D-loop; other site 1001582001981 H-loop/switch region; other site 1001582001982 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1001582001983 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1001582001984 Protein of unknown function, DUF600; Region: DUF600; cl04640 1001582001985 Protein of unknown function, DUF600; Region: DUF600; cl04640 1001582001986 Protein of unknown function, DUF600; Region: DUF600; pfam04634 1001582001987 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1001582001988 LXG domain of WXG superfamily; Region: LXG; pfam04740 1001582001989 hypothetical protein; Provisional; Region: PRK12378 1001582001990 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1001582001991 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1001582001992 CotJB protein; Region: CotJB; pfam12652 1001582001993 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1001582001994 dimanganese center [ion binding]; other site 1001582001995 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1001582001996 Coenzyme A binding pocket [chemical binding]; other site 1001582001997 YesK-like protein; Region: YesK; pfam14150 1001582001998 Predicted membrane protein [Function unknown]; Region: COG2323 1001582001999 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1001582002000 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1001582002001 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1001582002002 Uncharacterized small protein [Function unknown]; Region: COG5583 1001582002003 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1001582002004 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1001582002005 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582002006 MarR family; Region: MarR; pfam01047 1001582002007 hypothetical protein; Provisional; Region: PRK06847 1001582002008 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1001582002009 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1001582002010 Cytochrome P450; Region: p450; pfam00067 1001582002011 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1001582002012 Flavodoxin; Region: Flavodoxin_1; pfam00258 1001582002013 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1001582002014 FAD binding pocket [chemical binding]; other site 1001582002015 FAD binding motif [chemical binding]; other site 1001582002016 catalytic residues [active] 1001582002017 NAD binding pocket [chemical binding]; other site 1001582002018 phosphate binding motif [ion binding]; other site 1001582002019 beta-alpha-beta structure motif; other site 1001582002020 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1001582002021 Sulfatase; Region: Sulfatase; pfam00884 1001582002022 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1001582002023 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1001582002024 substrate binding site; other site 1001582002025 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1001582002026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001582002027 NAD(P) binding site [chemical binding]; other site 1001582002028 active site 1001582002029 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1001582002030 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1001582002031 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1001582002032 active site 1001582002033 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1001582002034 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 1001582002035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582002036 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582002037 putative substrate translocation pore; other site 1001582002038 amino acid transporter; Region: 2A0306; TIGR00909 1001582002039 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1001582002040 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1001582002041 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1001582002042 NAD(P) binding site [chemical binding]; other site 1001582002043 catalytic residues [active] 1001582002044 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1001582002045 dimer interface [polypeptide binding]; other site 1001582002046 putative CheW interface [polypeptide binding]; other site 1001582002047 oxidoreductase; Provisional; Region: PRK07985 1001582002048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001582002049 NAD(P) binding site [chemical binding]; other site 1001582002050 active site 1001582002051 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1001582002052 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1001582002053 putative metal binding site; other site 1001582002054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1001582002055 binding surface 1001582002056 TPR motif; other site 1001582002057 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1001582002058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582002059 Walker A/P-loop; other site 1001582002060 ATP binding site [chemical binding]; other site 1001582002061 Q-loop/lid; other site 1001582002062 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001582002063 ABC transporter signature motif; other site 1001582002064 Walker B; other site 1001582002065 D-loop; other site 1001582002066 ABC transporter; Region: ABC_tran_2; pfam12848 1001582002067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001582002068 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1001582002069 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1001582002070 DNA binding residues [nucleotide binding] 1001582002071 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1001582002072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582002073 putative substrate translocation pore; other site 1001582002074 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1001582002075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582002076 Walker A/P-loop; other site 1001582002077 ATP binding site [chemical binding]; other site 1001582002078 Q-loop/lid; other site 1001582002079 ABC transporter signature motif; other site 1001582002080 Walker B; other site 1001582002081 D-loop; other site 1001582002082 H-loop/switch region; other site 1001582002083 ABC transporter; Region: ABC_tran_2; pfam12848 1001582002084 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001582002085 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1001582002086 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1001582002087 ATP binding site [chemical binding]; other site 1001582002088 Mg++ binding site [ion binding]; other site 1001582002089 motif III; other site 1001582002090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001582002091 nucleotide binding region [chemical binding]; other site 1001582002092 ATP-binding site [chemical binding]; other site 1001582002093 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1001582002094 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1001582002095 NAD(P) binding site [chemical binding]; other site 1001582002096 substrate binding site [chemical binding]; other site 1001582002097 dimer interface [polypeptide binding]; other site 1001582002098 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1001582002099 Heat induced stress protein YflT; Region: YflT; pfam11181 1001582002100 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1001582002101 Amb_all domain; Region: Amb_all; smart00656 1001582002102 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1001582002103 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1001582002104 transmembrane helices; other site 1001582002105 BclB C-terminal domain; Region: exospore_TM; TIGR03721 1001582002106 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1001582002107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001582002108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582002109 dimer interface [polypeptide binding]; other site 1001582002110 phosphorylation site [posttranslational modification] 1001582002111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582002112 ATP binding site [chemical binding]; other site 1001582002113 Mg2+ binding site [ion binding]; other site 1001582002114 G-X-G motif; other site 1001582002115 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1001582002116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582002117 active site 1001582002118 phosphorylation site [posttranslational modification] 1001582002119 intermolecular recognition site; other site 1001582002120 dimerization interface [polypeptide binding]; other site 1001582002121 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1001582002122 Histidine kinase; Region: His_kinase; pfam06580 1001582002123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582002124 ATP binding site [chemical binding]; other site 1001582002125 Mg2+ binding site [ion binding]; other site 1001582002126 G-X-G motif; other site 1001582002127 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1001582002128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582002129 active site 1001582002130 phosphorylation site [posttranslational modification] 1001582002131 intermolecular recognition site; other site 1001582002132 dimerization interface [polypeptide binding]; other site 1001582002133 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1001582002134 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1001582002135 Collagen binding domain; Region: Collagen_bind; pfam05737 1001582002136 Collagen binding domain; Region: Collagen_bind; pfam05737 1001582002137 Collagen binding domain; Region: Collagen_bind; pfam05737 1001582002138 Collagen binding domain; Region: Collagen_bind; pfam05737 1001582002139 Cna protein B-type domain; Region: Cna_B; pfam05738 1001582002140 Cna protein B-type domain; Region: Cna_B; pfam05738 1001582002141 Cna protein B-type domain; Region: Cna_B; pfam05738 1001582002142 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1001582002143 Cna protein B-type domain; Region: Cna_B; pfam05738 1001582002144 Cna protein B-type domain; Region: Cna_B; pfam05738 1001582002145 Cna protein B-type domain; Region: Cna_B; pfam05738 1001582002146 Cna protein B-type domain; Region: Cna_B; pfam05738 1001582002147 Cna protein B-type domain; Region: Cna_B; pfam05738 1001582002148 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1001582002149 active site 1001582002150 catalytic site [active] 1001582002151 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1001582002152 PAS domain; Region: PAS; smart00091 1001582002153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582002154 ATP binding site [chemical binding]; other site 1001582002155 Mg2+ binding site [ion binding]; other site 1001582002156 G-X-G motif; other site 1001582002157 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1001582002158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582002159 active site 1001582002160 phosphorylation site [posttranslational modification] 1001582002161 intermolecular recognition site; other site 1001582002162 dimerization interface [polypeptide binding]; other site 1001582002163 Transcriptional regulator; Region: CitT; pfam12431 1001582002164 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1001582002165 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1001582002166 Citrate transporter; Region: CitMHS; pfam03600 1001582002167 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1001582002168 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1001582002169 active site 1001582002170 dimer interface [polypeptide binding]; other site 1001582002171 Acylphosphatase; Region: Acylphosphatase; cl00551 1001582002172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1001582002173 MOSC domain; Region: MOSC; pfam03473 1001582002174 3-alpha domain; Region: 3-alpha; pfam03475 1001582002175 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1001582002176 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1001582002177 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1001582002178 active site 1001582002179 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1001582002180 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1001582002181 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1001582002182 active site turn [active] 1001582002183 phosphorylation site [posttranslational modification] 1001582002184 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1001582002185 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1001582002186 Sulfatase; Region: Sulfatase; pfam00884 1001582002187 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1001582002188 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1001582002189 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1001582002190 putative dimer interface [polypeptide binding]; other site 1001582002191 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1001582002192 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1001582002193 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1001582002194 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1001582002195 active site turn [active] 1001582002196 phosphorylation site [posttranslational modification] 1001582002197 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1001582002198 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1001582002199 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1001582002200 Ca binding site [ion binding]; other site 1001582002201 active site 1001582002202 catalytic site [active] 1001582002203 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1001582002204 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582002205 DNA-binding site [nucleotide binding]; DNA binding site 1001582002206 UTRA domain; Region: UTRA; pfam07702 1001582002207 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1001582002208 dimer interface [polypeptide binding]; other site 1001582002209 FMN binding site [chemical binding]; other site 1001582002210 YibE/F-like protein; Region: YibE_F; pfam07907 1001582002211 YibE/F-like protein; Region: YibE_F; pfam07907 1001582002212 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1001582002213 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1001582002214 active site 1001582002215 metal binding site [ion binding]; metal-binding site 1001582002216 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1001582002217 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1001582002218 active site 1001582002219 metal binding site [ion binding]; metal-binding site 1001582002220 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1001582002221 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1001582002222 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1001582002223 proposed catalytic triad [active] 1001582002224 conserved cys residue [active] 1001582002225 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001582002226 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001582002227 DNA binding site [nucleotide binding] 1001582002228 domain linker motif; other site 1001582002229 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1001582002230 putative dimerization interface [polypeptide binding]; other site 1001582002231 putative ligand binding site [chemical binding]; other site 1001582002232 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1001582002233 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1001582002234 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1001582002235 shikimate binding site; other site 1001582002236 NAD(P) binding site [chemical binding]; other site 1001582002237 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1001582002238 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1001582002239 active site 1001582002240 catalytic residue [active] 1001582002241 dimer interface [polypeptide binding]; other site 1001582002242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582002243 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582002244 putative substrate translocation pore; other site 1001582002245 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1001582002246 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1001582002247 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1001582002248 active site 1001582002249 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1001582002250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582002251 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582002252 putative substrate translocation pore; other site 1001582002253 calcium/proton exchanger (cax); Region: cax; TIGR00378 1001582002254 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1001582002255 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1001582002256 YfkD-like protein; Region: YfkD; pfam14167 1001582002257 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1001582002258 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1001582002259 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1001582002260 YfkB-like domain; Region: YfkB; pfam08756 1001582002261 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1001582002262 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1001582002263 NodB motif; other site 1001582002264 active site 1001582002265 catalytic site [active] 1001582002266 Cd binding site [ion binding]; other site 1001582002267 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1001582002268 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1001582002269 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1001582002270 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1001582002271 oligomer interface [polypeptide binding]; other site 1001582002272 metal binding site [ion binding]; metal-binding site 1001582002273 metal binding site [ion binding]; metal-binding site 1001582002274 putative Cl binding site [ion binding]; other site 1001582002275 aspartate ring; other site 1001582002276 basic sphincter; other site 1001582002277 hydrophobic gate; other site 1001582002278 periplasmic entrance; other site 1001582002279 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1001582002280 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1001582002281 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1001582002282 minor groove reading motif; other site 1001582002283 helix-hairpin-helix signature motif; other site 1001582002284 substrate binding pocket [chemical binding]; other site 1001582002285 active site 1001582002286 TRAM domain; Region: TRAM; pfam01938 1001582002287 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1001582002288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582002289 S-adenosylmethionine binding site [chemical binding]; other site 1001582002290 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1001582002291 active site 1001582002292 catalytic residues [active] 1001582002293 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1001582002294 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001582002295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582002296 Walker A/P-loop; other site 1001582002297 ATP binding site [chemical binding]; other site 1001582002298 Q-loop/lid; other site 1001582002299 ABC transporter signature motif; other site 1001582002300 Walker B; other site 1001582002301 D-loop; other site 1001582002302 H-loop/switch region; other site 1001582002303 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1001582002304 active site 1001582002305 ATP binding site [chemical binding]; other site 1001582002306 substrate binding site [chemical binding]; other site 1001582002307 activation loop (A-loop); other site 1001582002308 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1001582002309 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1001582002310 active site 1001582002311 zinc binding site [ion binding]; other site 1001582002312 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1001582002313 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1001582002314 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1001582002315 FMN binding site [chemical binding]; other site 1001582002316 active site 1001582002317 catalytic residues [active] 1001582002318 substrate binding site [chemical binding]; other site 1001582002319 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1001582002320 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1001582002321 tetramer interface [polypeptide binding]; other site 1001582002322 TPP-binding site [chemical binding]; other site 1001582002323 heterodimer interface [polypeptide binding]; other site 1001582002324 phosphorylation loop region [posttranslational modification] 1001582002325 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1001582002326 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1001582002327 alpha subunit interface [polypeptide binding]; other site 1001582002328 TPP binding site [chemical binding]; other site 1001582002329 heterodimer interface [polypeptide binding]; other site 1001582002330 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1001582002331 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1001582002332 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1001582002333 E3 interaction surface; other site 1001582002334 lipoyl attachment site [posttranslational modification]; other site 1001582002335 e3 binding domain; Region: E3_binding; pfam02817 1001582002336 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1001582002337 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1001582002338 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001582002339 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1001582002340 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1001582002341 GAF domain; Region: GAF; pfam01590 1001582002342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582002343 Walker A motif; other site 1001582002344 ATP binding site [chemical binding]; other site 1001582002345 Walker B motif; other site 1001582002346 arginine finger; other site 1001582002347 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1001582002348 Small acid-soluble spore protein H family; Region: SspH; pfam08141 1001582002349 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1001582002350 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1001582002351 NAD binding site [chemical binding]; other site 1001582002352 sugar binding site [chemical binding]; other site 1001582002353 divalent metal binding site [ion binding]; other site 1001582002354 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1001582002355 dimer interface [polypeptide binding]; other site 1001582002356 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1001582002357 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1001582002358 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1001582002359 putative active site [active] 1001582002360 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1001582002361 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1001582002362 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1001582002363 active site turn [active] 1001582002364 phosphorylation site [posttranslational modification] 1001582002365 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1001582002366 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1001582002367 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1001582002368 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001582002369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582002370 Walker A/P-loop; other site 1001582002371 ATP binding site [chemical binding]; other site 1001582002372 Q-loop/lid; other site 1001582002373 ABC transporter signature motif; other site 1001582002374 Walker B; other site 1001582002375 D-loop; other site 1001582002376 H-loop/switch region; other site 1001582002377 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1001582002378 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001582002379 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1001582002380 Walker A/P-loop; other site 1001582002381 ATP binding site [chemical binding]; other site 1001582002382 Q-loop/lid; other site 1001582002383 ABC transporter signature motif; other site 1001582002384 Walker B; other site 1001582002385 D-loop; other site 1001582002386 H-loop/switch region; other site 1001582002387 Predicted membrane protein [Function unknown]; Region: COG2259 1001582002388 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1001582002389 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1001582002390 putative metal binding site [ion binding]; other site 1001582002391 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1001582002392 active site 1001582002393 potential frameshift: common BLAST hit: gi|375361509|ref|YP_005129548.1| protoheme IX farnesyltransferase 1001582002394 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1001582002395 UbiA prenyltransferase family; Region: UbiA; pfam01040 1001582002396 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1001582002397 UbiA prenyltransferase family; Region: UbiA; pfam01040 1001582002398 Predicted transcriptional regulators [Transcription]; Region: COG1695 1001582002399 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1001582002400 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1001582002401 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1001582002402 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1001582002403 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1001582002404 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1001582002405 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1001582002406 RNAase interaction site [polypeptide binding]; other site 1001582002407 metal-dependent hydrolase; Provisional; Region: PRK13291 1001582002408 DinB superfamily; Region: DinB_2; pfam12867 1001582002409 benzoate transport; Region: 2A0115; TIGR00895 1001582002410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582002411 putative substrate translocation pore; other site 1001582002412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582002413 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582002414 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582002415 putative Zn2+ binding site [ion binding]; other site 1001582002416 putative DNA binding site [nucleotide binding]; other site 1001582002417 Predicted integral membrane protein [Function unknown]; Region: COG0392 1001582002418 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1001582002419 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1001582002420 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1001582002421 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1001582002422 putative FMN binding site [chemical binding]; other site 1001582002423 YfhD-like protein; Region: YfhD; pfam14151 1001582002424 YfhE-like protein; Region: YfhE; pfam14152 1001582002425 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1001582002426 TIGR01777 family protein; Region: yfcH 1001582002427 putative NAD(P) binding site [chemical binding]; other site 1001582002428 putative active site [active] 1001582002429 recombination regulator RecX; Provisional; Region: recX; PRK14135 1001582002430 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1001582002431 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1001582002432 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1001582002433 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 1001582002434 WVELL protein; Region: WVELL; pfam14043 1001582002435 Bacterial SH3 domain; Region: SH3_3; pfam08239 1001582002436 Bacterial SH3 domain; Region: SH3_3; cl17532 1001582002437 SdpI/YhfL protein family; Region: SdpI; pfam13630 1001582002438 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1001582002439 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1001582002440 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1001582002441 Ligand binding site; other site 1001582002442 Putative Catalytic site; other site 1001582002443 DXD motif; other site 1001582002444 Predicted membrane protein [Function unknown]; Region: COG4485 1001582002445 Caenorhabditis protein of unknown function, DUF267; Region: DUF267; pfam03268 1001582002446 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1001582002447 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1001582002448 Int/Topo IB signature motif; other site 1001582002449 Domain of unknown function (DUF955); Region: DUF955; cl01076 1001582002450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1001582002451 sequence-specific DNA binding site [nucleotide binding]; other site 1001582002452 salt bridge; other site 1001582002453 Helix-turn-helix; Region: HTH_3; pfam01381 1001582002454 non-specific DNA binding site [nucleotide binding]; other site 1001582002455 salt bridge; other site 1001582002456 sequence-specific DNA binding site [nucleotide binding]; other site 1001582002457 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1001582002458 ORF6C domain; Region: ORF6C; pfam10552 1001582002459 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1001582002460 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1001582002461 replicative DNA helicase; Region: DnaB; TIGR00665 1001582002462 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1001582002463 Walker A motif; other site 1001582002464 ATP binding site [chemical binding]; other site 1001582002465 Walker B motif; other site 1001582002466 DNA binding loops [nucleotide binding] 1001582002467 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1001582002468 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1001582002469 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1001582002470 active site 1001582002471 Phage terminase, small subunit; Region: Terminase_4; cl01525 1001582002472 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1001582002473 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1001582002474 Phage portal protein; Region: Phage_portal; pfam04860 1001582002475 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1001582002476 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1001582002477 oligomer interface [polypeptide binding]; other site 1001582002478 active site residues [active] 1001582002479 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1001582002480 Phage capsid family; Region: Phage_capsid; pfam05065 1001582002481 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1001582002482 oligomerization interface [polypeptide binding]; other site 1001582002483 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1001582002484 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1001582002485 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1001582002486 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1001582002487 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1001582002488 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1001582002489 catalytic residue [active] 1001582002490 Phage tail protein; Region: Sipho_tail; pfam05709 1001582002491 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1001582002492 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1001582002493 active site 1001582002494 catalytic triad [active] 1001582002495 oxyanion hole [active] 1001582002496 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1001582002497 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1001582002498 dimer interface [polypeptide binding]; other site 1001582002499 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 1001582002500 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1001582002501 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 1001582002502 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1001582002503 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1001582002504 amidase catalytic site [active] 1001582002505 Zn binding residues [ion binding]; other site 1001582002506 substrate binding site [chemical binding]; other site 1001582002507 Bacterial SH3 domain; Region: SH3_3; cl17532 1001582002508 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1001582002509 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1001582002510 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1001582002511 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1001582002512 minor groove reading motif; other site 1001582002513 helix-hairpin-helix signature motif; other site 1001582002514 substrate binding pocket [chemical binding]; other site 1001582002515 active site 1001582002516 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1001582002517 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1001582002518 DNA binding and oxoG recognition site [nucleotide binding] 1001582002519 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1001582002520 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1001582002521 putative NAD(P) binding site [chemical binding]; other site 1001582002522 active site 1001582002523 YgaB-like protein; Region: YgaB; pfam14182 1001582002524 hypothetical protein; Provisional; Region: PRK13662 1001582002525 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1001582002526 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001582002527 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1001582002528 Walker A/P-loop; other site 1001582002529 ATP binding site [chemical binding]; other site 1001582002530 Q-loop/lid; other site 1001582002531 ABC transporter signature motif; other site 1001582002532 Walker B; other site 1001582002533 D-loop; other site 1001582002534 H-loop/switch region; other site 1001582002535 Predicted membrane protein [Function unknown]; Region: COG4129 1001582002536 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1001582002537 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1001582002538 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1001582002539 inhibitor-cofactor binding pocket; inhibition site 1001582002540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582002541 catalytic residue [active] 1001582002542 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1001582002543 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1001582002544 catalytic triad [active] 1001582002545 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1001582002546 metal binding site 2 [ion binding]; metal-binding site 1001582002547 putative DNA binding helix; other site 1001582002548 metal binding site 1 [ion binding]; metal-binding site 1001582002549 dimer interface [polypeptide binding]; other site 1001582002550 structural Zn2+ binding site [ion binding]; other site 1001582002551 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1001582002552 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1001582002553 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1001582002554 active site pocket [active] 1001582002555 oxyanion hole [active] 1001582002556 catalytic triad [active] 1001582002557 active site nucleophile [active] 1001582002558 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1001582002559 ThiC-associated domain; Region: ThiC-associated; pfam13667 1001582002560 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1001582002561 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1001582002562 Berberine and berberine like; Region: BBE; pfam08031 1001582002563 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1001582002564 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1001582002565 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1001582002566 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1001582002567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582002568 dimer interface [polypeptide binding]; other site 1001582002569 conserved gate region; other site 1001582002570 putative PBP binding loops; other site 1001582002571 ABC-ATPase subunit interface; other site 1001582002572 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1001582002573 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1001582002574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582002575 dimer interface [polypeptide binding]; other site 1001582002576 conserved gate region; other site 1001582002577 putative PBP binding loops; other site 1001582002578 ABC-ATPase subunit interface; other site 1001582002579 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1001582002580 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1001582002581 Walker A/P-loop; other site 1001582002582 ATP binding site [chemical binding]; other site 1001582002583 Q-loop/lid; other site 1001582002584 ABC transporter signature motif; other site 1001582002585 Walker B; other site 1001582002586 D-loop; other site 1001582002587 H-loop/switch region; other site 1001582002588 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1001582002589 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1001582002590 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1001582002591 Walker A/P-loop; other site 1001582002592 ATP binding site [chemical binding]; other site 1001582002593 Q-loop/lid; other site 1001582002594 ABC transporter signature motif; other site 1001582002595 Walker B; other site 1001582002596 D-loop; other site 1001582002597 H-loop/switch region; other site 1001582002598 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1001582002599 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1001582002600 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1001582002601 tetramer interface [polypeptide binding]; other site 1001582002602 heme binding pocket [chemical binding]; other site 1001582002603 NADPH binding site [chemical binding]; other site 1001582002604 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1001582002605 active site 1001582002606 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1001582002607 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1001582002608 Walker A/P-loop; other site 1001582002609 ATP binding site [chemical binding]; other site 1001582002610 Q-loop/lid; other site 1001582002611 ABC transporter signature motif; other site 1001582002612 Walker B; other site 1001582002613 D-loop; other site 1001582002614 H-loop/switch region; other site 1001582002615 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1001582002616 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1001582002617 substrate binding pocket [chemical binding]; other site 1001582002618 membrane-bound complex binding site; other site 1001582002619 hinge residues; other site 1001582002620 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1001582002621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582002622 dimer interface [polypeptide binding]; other site 1001582002623 conserved gate region; other site 1001582002624 putative PBP binding loops; other site 1001582002625 ABC-ATPase subunit interface; other site 1001582002626 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1001582002627 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1001582002628 active site 1001582002629 dimer interface [polypeptide binding]; other site 1001582002630 non-prolyl cis peptide bond; other site 1001582002631 insertion regions; other site 1001582002632 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1001582002633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582002634 non-specific DNA binding site [nucleotide binding]; other site 1001582002635 salt bridge; other site 1001582002636 sequence-specific DNA binding site [nucleotide binding]; other site 1001582002637 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1001582002638 epoxyqueuosine reductase; Region: TIGR00276 1001582002639 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1001582002640 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1001582002641 Putative amidase domain; Region: Amidase_6; pfam12671 1001582002642 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 1001582002643 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1001582002644 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1001582002645 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1001582002646 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1001582002647 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1001582002648 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1001582002649 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1001582002650 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582002651 MarR family; Region: MarR; pfam01047 1001582002652 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1001582002653 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1001582002654 carboxyltransferase (CT) interaction site; other site 1001582002655 biotinylation site [posttranslational modification]; other site 1001582002656 HlyD family secretion protein; Region: HlyD_3; pfam13437 1001582002657 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1001582002658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582002659 putative substrate translocation pore; other site 1001582002660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582002661 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1001582002662 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1001582002663 Predicted transcriptional regulators [Transcription]; Region: COG1725 1001582002664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582002665 DNA-binding site [nucleotide binding]; DNA binding site 1001582002666 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1001582002667 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1001582002668 Walker A/P-loop; other site 1001582002669 ATP binding site [chemical binding]; other site 1001582002670 Q-loop/lid; other site 1001582002671 ABC transporter signature motif; other site 1001582002672 Walker B; other site 1001582002673 D-loop; other site 1001582002674 H-loop/switch region; other site 1001582002675 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1001582002676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582002677 Walker A/P-loop; other site 1001582002678 ATP binding site [chemical binding]; other site 1001582002679 Q-loop/lid; other site 1001582002680 ABC transporter signature motif; other site 1001582002681 Walker B; other site 1001582002682 D-loop; other site 1001582002683 H-loop/switch region; other site 1001582002684 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1001582002685 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1001582002686 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1001582002687 DNA-binding site [nucleotide binding]; DNA binding site 1001582002688 RNA-binding motif; other site 1001582002689 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1001582002690 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1001582002691 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1001582002692 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1001582002693 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1001582002694 metal binding site [ion binding]; metal-binding site 1001582002695 active site 1001582002696 I-site; other site 1001582002697 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1001582002698 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1001582002699 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1001582002700 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1001582002701 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1001582002702 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1001582002703 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1001582002704 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1001582002705 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1001582002706 putative active site [active] 1001582002707 putative metal binding site [ion binding]; other site 1001582002708 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1001582002709 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1001582002710 active site 1001582002711 catalytic site [active] 1001582002712 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1001582002713 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1001582002714 active site 1001582002715 FOG: CBS domain [General function prediction only]; Region: COG0517 1001582002716 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1001582002717 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1001582002718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582002719 motif II; other site 1001582002720 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1001582002721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582002722 Coenzyme A binding pocket [chemical binding]; other site 1001582002723 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1001582002724 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1001582002725 putative active site [active] 1001582002726 catalytic triad [active] 1001582002727 putative dimer interface [polypeptide binding]; other site 1001582002728 aminotransferase; Validated; Region: PRK07678 1001582002729 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1001582002730 inhibitor-cofactor binding pocket; inhibition site 1001582002731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582002732 catalytic residue [active] 1001582002733 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1001582002734 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1001582002735 amphipathic channel; other site 1001582002736 Asn-Pro-Ala signature motifs; other site 1001582002737 glycerol kinase; Provisional; Region: glpK; PRK00047 1001582002738 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1001582002739 N- and C-terminal domain interface [polypeptide binding]; other site 1001582002740 active site 1001582002741 MgATP binding site [chemical binding]; other site 1001582002742 catalytic site [active] 1001582002743 metal binding site [ion binding]; metal-binding site 1001582002744 glycerol binding site [chemical binding]; other site 1001582002745 homotetramer interface [polypeptide binding]; other site 1001582002746 homodimer interface [polypeptide binding]; other site 1001582002747 FBP binding site [chemical binding]; other site 1001582002748 protein IIAGlc interface [polypeptide binding]; other site 1001582002749 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1001582002750 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1001582002751 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1001582002752 active site 1001582002753 substrate binding site [chemical binding]; other site 1001582002754 metal binding site [ion binding]; metal-binding site 1001582002755 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1001582002756 GAF domain; Region: GAF; pfam01590 1001582002757 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1001582002758 Histidine kinase; Region: HisKA_3; pfam07730 1001582002759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582002760 ATP binding site [chemical binding]; other site 1001582002761 Mg2+ binding site [ion binding]; other site 1001582002762 G-X-G motif; other site 1001582002763 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1001582002764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582002765 active site 1001582002766 phosphorylation site [posttranslational modification] 1001582002767 intermolecular recognition site; other site 1001582002768 dimerization interface [polypeptide binding]; other site 1001582002769 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1001582002770 DNA binding residues [nucleotide binding] 1001582002771 dimerization interface [polypeptide binding]; other site 1001582002772 Predicted flavoprotein [General function prediction only]; Region: COG0431 1001582002773 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1001582002774 YhdB-like protein; Region: YhdB; pfam14148 1001582002775 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1001582002776 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582002777 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582002778 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582002779 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582002780 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1001582002781 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582002782 NlpC/P60 family; Region: NLPC_P60; pfam00877 1001582002783 Transcriptional regulator; Region: Rrf2; cl17282 1001582002784 Rrf2 family protein; Region: rrf2_super; TIGR00738 1001582002785 Conserved TM helix; Region: TM_helix; pfam05552 1001582002786 Conserved TM helix; Region: TM_helix; pfam05552 1001582002787 Conserved TM helix; Region: TM_helix; pfam05552 1001582002788 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1001582002789 SpoVR like protein; Region: SpoVR; pfam04293 1001582002790 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1001582002791 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1001582002792 dimer interface [polypeptide binding]; other site 1001582002793 active site 1001582002794 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582002795 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582002796 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1001582002797 NlpC/P60 family; Region: NLPC_P60; pfam00877 1001582002798 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001582002799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001582002800 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1001582002801 dimerization interface [polypeptide binding]; other site 1001582002802 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1001582002803 dimer interface [polypeptide binding]; other site 1001582002804 Citrate synthase; Region: Citrate_synt; pfam00285 1001582002805 active site 1001582002806 citrylCoA binding site [chemical binding]; other site 1001582002807 oxalacetate/citrate binding site [chemical binding]; other site 1001582002808 coenzyme A binding site [chemical binding]; other site 1001582002809 catalytic triad [active] 1001582002810 short chain dehydrogenase; Provisional; Region: PRK06701 1001582002811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001582002812 NAD(P) binding site [chemical binding]; other site 1001582002813 active site 1001582002814 amino acid transporter; Region: 2A0306; TIGR00909 1001582002815 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1001582002816 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1001582002817 putative substrate binding site 2 [chemical binding]; other site 1001582002818 putative substrate binding site 1 [chemical binding]; other site 1001582002819 Na binding site 1 [ion binding]; other site 1001582002820 Na2 binding site [ion binding]; other site 1001582002821 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1001582002822 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1001582002823 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1001582002824 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001582002825 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582002826 DNA binding residues [nucleotide binding] 1001582002827 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1001582002828 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1001582002829 putative acyl-acceptor binding pocket; other site 1001582002830 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1001582002831 Domain of unknown function DUF21; Region: DUF21; pfam01595 1001582002832 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1001582002833 Transporter associated domain; Region: CorC_HlyC; smart01091 1001582002834 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1001582002835 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1001582002836 DNA binding residues [nucleotide binding] 1001582002837 putative dimer interface [polypeptide binding]; other site 1001582002838 aspartate aminotransferase; Provisional; Region: PRK06836 1001582002839 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001582002840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582002841 homodimer interface [polypeptide binding]; other site 1001582002842 catalytic residue [active] 1001582002843 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1001582002844 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1001582002845 dimer interface [polypeptide binding]; other site 1001582002846 active site 1001582002847 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1001582002848 Domain of unknown function DUF21; Region: DUF21; pfam01595 1001582002849 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1001582002850 Transporter associated domain; Region: CorC_HlyC; smart01091 1001582002851 camphor resistance protein CrcB; Provisional; Region: PRK14213 1001582002852 CrcB-like protein; Region: CRCB; cl09114 1001582002853 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1001582002854 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1001582002855 active site 1001582002856 catalytic site [active] 1001582002857 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1001582002858 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1001582002859 NAD-dependent deacetylase; Provisional; Region: PRK00481 1001582002860 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1001582002861 NAD+ binding site [chemical binding]; other site 1001582002862 substrate binding site [chemical binding]; other site 1001582002863 Zn binding site [ion binding]; other site 1001582002864 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1001582002865 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1001582002866 NodB motif; other site 1001582002867 active site 1001582002868 catalytic site [active] 1001582002869 Zn binding site [ion binding]; other site 1001582002870 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1001582002871 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1001582002872 homodimer interface [polypeptide binding]; other site 1001582002873 substrate-cofactor binding pocket; other site 1001582002874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582002875 catalytic residue [active] 1001582002876 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1001582002877 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582002878 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1001582002879 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1001582002880 Ligand Binding Site [chemical binding]; other site 1001582002881 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1001582002882 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001582002883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582002884 Walker A/P-loop; other site 1001582002885 ATP binding site [chemical binding]; other site 1001582002886 Q-loop/lid; other site 1001582002887 ABC transporter signature motif; other site 1001582002888 Walker B; other site 1001582002889 D-loop; other site 1001582002890 H-loop/switch region; other site 1001582002891 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1001582002892 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001582002893 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1001582002894 Walker A/P-loop; other site 1001582002895 ATP binding site [chemical binding]; other site 1001582002896 Q-loop/lid; other site 1001582002897 ABC transporter signature motif; other site 1001582002898 Walker B; other site 1001582002899 D-loop; other site 1001582002900 H-loop/switch region; other site 1001582002901 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1001582002902 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1001582002903 NAD binding site [chemical binding]; other site 1001582002904 substrate binding site [chemical binding]; other site 1001582002905 putative active site [active] 1001582002906 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1001582002907 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1001582002908 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1001582002909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1001582002910 hypothetical protein; Provisional; Region: PRK13676 1001582002911 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1001582002912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582002913 active site 1001582002914 motif I; other site 1001582002915 motif II; other site 1001582002916 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1001582002917 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1001582002918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001582002919 FeS/SAM binding site; other site 1001582002920 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1001582002921 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1001582002922 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1001582002923 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1001582002924 TrkA-C domain; Region: TrkA_C; pfam02080 1001582002925 enoyl-CoA hydratase; Provisional; Region: PRK07659 1001582002926 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1001582002927 substrate binding site [chemical binding]; other site 1001582002928 oxyanion hole (OAH) forming residues; other site 1001582002929 trimer interface [polypeptide binding]; other site 1001582002930 YhzD-like protein; Region: YhzD; pfam14120 1001582002931 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1001582002932 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1001582002933 Walker A/P-loop; other site 1001582002934 ATP binding site [chemical binding]; other site 1001582002935 Q-loop/lid; other site 1001582002936 ABC transporter signature motif; other site 1001582002937 Walker B; other site 1001582002938 D-loop; other site 1001582002939 H-loop/switch region; other site 1001582002940 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1001582002941 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1001582002942 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1001582002943 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1001582002944 active site 1001582002945 metal binding site [ion binding]; metal-binding site 1001582002946 DNA binding site [nucleotide binding] 1001582002947 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1001582002948 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1001582002949 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1001582002950 generic binding surface II; other site 1001582002951 generic binding surface I; other site 1001582002952 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001582002953 Zn2+ binding site [ion binding]; other site 1001582002954 Mg2+ binding site [ion binding]; other site 1001582002955 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1001582002956 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1001582002957 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1001582002958 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1001582002959 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1001582002960 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1001582002961 transcriptional regulator Hpr; Provisional; Region: PRK13777 1001582002962 MarR family; Region: MarR; pfam01047 1001582002963 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1001582002964 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1001582002965 homodimer interface [polypeptide binding]; other site 1001582002966 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1001582002967 substrate-cofactor binding pocket; other site 1001582002968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582002969 catalytic residue [active] 1001582002970 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1001582002971 HIT family signature motif; other site 1001582002972 catalytic residue [active] 1001582002973 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1001582002974 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1001582002975 Walker A/P-loop; other site 1001582002976 ATP binding site [chemical binding]; other site 1001582002977 Q-loop/lid; other site 1001582002978 ABC transporter signature motif; other site 1001582002979 Walker B; other site 1001582002980 D-loop; other site 1001582002981 H-loop/switch region; other site 1001582002982 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1001582002983 EcsC protein family; Region: EcsC; pfam12787 1001582002984 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1001582002985 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1001582002986 metal binding site [ion binding]; metal-binding site 1001582002987 dimer interface [polypeptide binding]; other site 1001582002988 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1001582002989 Transglycosylase; Region: Transgly; pfam00912 1001582002990 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1001582002991 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1001582002992 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1001582002993 substrate binding site [chemical binding]; other site 1001582002994 active site 1001582002995 ferrochelatase; Provisional; Region: PRK12435 1001582002996 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1001582002997 C-terminal domain interface [polypeptide binding]; other site 1001582002998 active site 1001582002999 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1001582003000 active site 1001582003001 N-terminal domain interface [polypeptide binding]; other site 1001582003002 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1001582003003 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1001582003004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582003005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582003006 Predicted membrane protein [Function unknown]; Region: COG1511 1001582003007 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1001582003008 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1001582003009 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1001582003010 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1001582003011 dimer interface [polypeptide binding]; other site 1001582003012 active site 1001582003013 CoA binding pocket [chemical binding]; other site 1001582003014 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1001582003015 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1001582003016 putative oligomer interface [polypeptide binding]; other site 1001582003017 putative active site [active] 1001582003018 metal binding site [ion binding]; metal-binding site 1001582003019 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1001582003020 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1001582003021 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1001582003022 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1001582003023 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1001582003024 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1001582003025 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1001582003026 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1001582003027 NAD(P) binding site [chemical binding]; other site 1001582003028 putative active site [active] 1001582003029 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1001582003030 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1001582003031 acyl-activating enzyme (AAE) consensus motif; other site 1001582003032 putative AMP binding site [chemical binding]; other site 1001582003033 putative active site [active] 1001582003034 putative CoA binding site [chemical binding]; other site 1001582003035 Peptidase family M48; Region: Peptidase_M48; pfam01435 1001582003036 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1001582003037 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1001582003038 active site 1001582003039 catalytic residues [active] 1001582003040 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1001582003041 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1001582003042 siderophore binding site; other site 1001582003043 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1001582003044 catalytic core [active] 1001582003045 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1001582003046 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1001582003047 dimer interface [polypeptide binding]; other site 1001582003048 active site 1001582003049 acyl-CoA synthetase; Validated; Region: PRK07638 1001582003050 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1001582003051 acyl-activating enzyme (AAE) consensus motif; other site 1001582003052 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1001582003053 acyl-activating enzyme (AAE) consensus motif; other site 1001582003054 active site 1001582003055 AMP binding site [chemical binding]; other site 1001582003056 CoA binding site [chemical binding]; other site 1001582003057 BioY family; Region: BioY; pfam02632 1001582003058 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1001582003059 heme-binding site [chemical binding]; other site 1001582003060 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1001582003061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1001582003062 dimer interface [polypeptide binding]; other site 1001582003063 putative CheW interface [polypeptide binding]; other site 1001582003064 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1001582003065 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1001582003066 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1001582003067 [2Fe-2S] cluster binding site [ion binding]; other site 1001582003068 short chain dehydrogenase; Provisional; Region: PRK06701 1001582003069 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1001582003070 NAD binding site [chemical binding]; other site 1001582003071 metal binding site [ion binding]; metal-binding site 1001582003072 active site 1001582003073 IDEAL domain; Region: IDEAL; pfam08858 1001582003074 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1001582003075 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1001582003076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1001582003077 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1001582003078 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1001582003079 putative binding site; other site 1001582003080 putative dimer interface [polypeptide binding]; other site 1001582003081 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1001582003082 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1001582003083 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1001582003084 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1001582003085 Na binding site [ion binding]; other site 1001582003086 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1001582003087 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1001582003088 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1001582003089 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1001582003090 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1001582003091 Catalytic site [active] 1001582003092 hypothetical protein; Provisional; Region: PRK08244 1001582003093 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1001582003094 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582003095 MarR family; Region: MarR; pfam01047 1001582003096 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1001582003097 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1001582003098 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1001582003099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582003100 putative substrate translocation pore; other site 1001582003101 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582003102 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582003103 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582003104 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1001582003105 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1001582003106 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1001582003107 dinuclear metal binding motif [ion binding]; other site 1001582003108 Predicted membrane protein [Function unknown]; Region: COG2323 1001582003109 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1001582003110 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1001582003111 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1001582003112 Part of AAA domain; Region: AAA_19; pfam13245 1001582003113 Family description; Region: UvrD_C_2; pfam13538 1001582003114 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1001582003115 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1001582003116 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1001582003117 active site 1001582003118 metal binding site [ion binding]; metal-binding site 1001582003119 DNA binding site [nucleotide binding] 1001582003120 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1001582003121 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1001582003122 AAA domain; Region: AAA_23; pfam13476 1001582003123 Walker A/P-loop; other site 1001582003124 ATP binding site [chemical binding]; other site 1001582003125 Q-loop/lid; other site 1001582003126 ABC transporter signature motif; other site 1001582003127 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1001582003128 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1001582003129 ABC transporter signature motif; other site 1001582003130 Walker B; other site 1001582003131 D-loop; other site 1001582003132 H-loop/switch region; other site 1001582003133 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1001582003134 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1001582003135 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1001582003136 Spore germination protein GerPC; Region: GerPC; pfam10737 1001582003137 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1001582003138 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1001582003139 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1001582003140 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1001582003141 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1001582003142 hypothetical protein; Provisional; Region: PRK13673 1001582003143 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1001582003144 active site 1001582003145 catalytic triad [active] 1001582003146 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1001582003147 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1001582003148 active site 1001582003149 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1001582003150 dimer interface [polypeptide binding]; other site 1001582003151 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1001582003152 Ligand Binding Site [chemical binding]; other site 1001582003153 Molecular Tunnel; other site 1001582003154 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1001582003155 substrate binding pocket [chemical binding]; other site 1001582003156 substrate-Mg2+ binding site; other site 1001582003157 aspartate-rich region 1; other site 1001582003158 aspartate-rich region 2; other site 1001582003159 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1001582003160 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1001582003161 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1001582003162 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1001582003163 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001582003164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001582003165 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001582003166 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001582003167 DNA binding site [nucleotide binding] 1001582003168 domain linker motif; other site 1001582003169 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1001582003170 dimerization interface [polypeptide binding]; other site 1001582003171 ligand binding site [chemical binding]; other site 1001582003172 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1001582003173 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1001582003174 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1001582003175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1001582003176 Lysine efflux permease [General function prediction only]; Region: COG1279 1001582003177 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1001582003178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582003179 DNA-binding site [nucleotide binding]; DNA binding site 1001582003180 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001582003181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582003182 homodimer interface [polypeptide binding]; other site 1001582003183 catalytic residue [active] 1001582003184 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1001582003185 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1001582003186 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1001582003187 Coenzyme A binding pocket [chemical binding]; other site 1001582003188 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1001582003189 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1001582003190 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1001582003191 FAD binding site [chemical binding]; other site 1001582003192 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1001582003193 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1001582003194 S1 domain; Region: S1_2; pfam13509 1001582003195 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1001582003196 RNA binding site [nucleotide binding]; other site 1001582003197 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1001582003198 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1001582003199 ligand binding site [chemical binding]; other site 1001582003200 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1001582003201 dimerization interface [polypeptide binding]; other site 1001582003202 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1001582003203 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1001582003204 dimer interface [polypeptide binding]; other site 1001582003205 putative CheW interface [polypeptide binding]; other site 1001582003206 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1001582003207 Cytochrome P450; Region: p450; cl12078 1001582003208 EDD domain protein, DegV family; Region: DegV; TIGR00762 1001582003209 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1001582003210 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1001582003211 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001582003212 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001582003213 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1001582003214 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1001582003215 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1001582003216 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1001582003217 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582003218 motif II; other site 1001582003219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582003220 esterase; Provisional; Region: PRK10566 1001582003221 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1001582003222 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1001582003223 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1001582003224 active site 1001582003225 metal binding site [ion binding]; metal-binding site 1001582003226 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1001582003227 FAD binding domain; Region: FAD_binding_4; pfam01565 1001582003228 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1001582003229 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582003230 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1001582003231 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1001582003232 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1001582003233 heterotetramer interface [polypeptide binding]; other site 1001582003234 active site pocket [active] 1001582003235 cleavage site 1001582003236 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1001582003237 nucleotide binding site [chemical binding]; other site 1001582003238 N-acetyl-L-glutamate binding site [chemical binding]; other site 1001582003239 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1001582003240 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1001582003241 inhibitor-cofactor binding pocket; inhibition site 1001582003242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582003243 catalytic residue [active] 1001582003244 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1001582003245 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1001582003246 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1001582003247 catalytic site [active] 1001582003248 subunit interface [polypeptide binding]; other site 1001582003249 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1001582003250 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1001582003251 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1001582003252 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1001582003253 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1001582003254 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1001582003255 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1001582003256 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1001582003257 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1001582003258 YjzC-like protein; Region: YjzC; pfam14168 1001582003259 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1001582003260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001582003261 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1001582003262 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1001582003263 putative ligand binding site [chemical binding]; other site 1001582003264 ComZ; Region: ComZ; pfam10815 1001582003265 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1001582003266 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1001582003267 dimer interface [polypeptide binding]; other site 1001582003268 active site 1001582003269 CoA binding pocket [chemical binding]; other site 1001582003270 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1001582003271 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1001582003272 dimer interface [polypeptide binding]; other site 1001582003273 active site 1001582003274 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1001582003275 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1001582003276 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1001582003277 Walker A/P-loop; other site 1001582003278 ATP binding site [chemical binding]; other site 1001582003279 Q-loop/lid; other site 1001582003280 ABC transporter signature motif; other site 1001582003281 Walker B; other site 1001582003282 D-loop; other site 1001582003283 H-loop/switch region; other site 1001582003284 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1001582003285 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1001582003286 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1001582003287 Walker A/P-loop; other site 1001582003288 ATP binding site [chemical binding]; other site 1001582003289 Q-loop/lid; other site 1001582003290 ABC transporter signature motif; other site 1001582003291 Walker B; other site 1001582003292 D-loop; other site 1001582003293 H-loop/switch region; other site 1001582003294 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1001582003295 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1001582003296 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1001582003297 peptide binding site [polypeptide binding]; other site 1001582003298 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1001582003299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582003300 dimer interface [polypeptide binding]; other site 1001582003301 conserved gate region; other site 1001582003302 putative PBP binding loops; other site 1001582003303 ABC-ATPase subunit interface; other site 1001582003304 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1001582003305 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1001582003306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582003307 dimer interface [polypeptide binding]; other site 1001582003308 conserved gate region; other site 1001582003309 putative PBP binding loops; other site 1001582003310 ABC-ATPase subunit interface; other site 1001582003311 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1001582003312 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1001582003313 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1001582003314 active site 1001582003315 HIGH motif; other site 1001582003316 dimer interface [polypeptide binding]; other site 1001582003317 KMSKS motif; other site 1001582003318 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1001582003319 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1001582003320 peptide binding site [polypeptide binding]; other site 1001582003321 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1001582003322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582003323 dimer interface [polypeptide binding]; other site 1001582003324 conserved gate region; other site 1001582003325 putative PBP binding loops; other site 1001582003326 ABC-ATPase subunit interface; other site 1001582003327 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1001582003328 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1001582003329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582003330 dimer interface [polypeptide binding]; other site 1001582003331 conserved gate region; other site 1001582003332 putative PBP binding loops; other site 1001582003333 ABC-ATPase subunit interface; other site 1001582003334 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1001582003335 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1001582003336 Walker A/P-loop; other site 1001582003337 ATP binding site [chemical binding]; other site 1001582003338 Q-loop/lid; other site 1001582003339 ABC transporter signature motif; other site 1001582003340 Walker B; other site 1001582003341 D-loop; other site 1001582003342 H-loop/switch region; other site 1001582003343 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1001582003344 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1001582003345 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1001582003346 Walker A/P-loop; other site 1001582003347 ATP binding site [chemical binding]; other site 1001582003348 Q-loop/lid; other site 1001582003349 ABC transporter signature motif; other site 1001582003350 Walker B; other site 1001582003351 D-loop; other site 1001582003352 H-loop/switch region; other site 1001582003353 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1001582003354 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1001582003355 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1001582003356 Coenzyme A binding pocket [chemical binding]; other site 1001582003357 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1001582003358 ArsC family; Region: ArsC; pfam03960 1001582003359 putative catalytic residues [active] 1001582003360 thiol/disulfide switch; other site 1001582003361 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1001582003362 adaptor protein; Provisional; Region: PRK02315 1001582003363 Competence protein CoiA-like family; Region: CoiA; cl11541 1001582003364 oligoendopeptidase F; Region: pepF; TIGR00181 1001582003365 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1001582003366 active site 1001582003367 Zn binding site [ion binding]; other site 1001582003368 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1001582003369 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1001582003370 catalytic residues [active] 1001582003371 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1001582003372 apolar tunnel; other site 1001582003373 heme binding site [chemical binding]; other site 1001582003374 dimerization interface [polypeptide binding]; other site 1001582003375 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1001582003376 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1001582003377 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1001582003378 catalytic residue [active] 1001582003379 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1001582003380 putative active site [active] 1001582003381 putative metal binding residues [ion binding]; other site 1001582003382 signature motif; other site 1001582003383 putative triphosphate binding site [ion binding]; other site 1001582003384 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1001582003385 synthetase active site [active] 1001582003386 NTP binding site [chemical binding]; other site 1001582003387 metal binding site [ion binding]; metal-binding site 1001582003388 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1001582003389 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1001582003390 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1001582003391 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1001582003392 active site 1001582003393 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1001582003394 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1001582003395 active site 1001582003396 metal binding site [ion binding]; metal-binding site 1001582003397 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1001582003398 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1001582003399 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1001582003400 TrkA-N domain; Region: TrkA_N; pfam02254 1001582003401 TrkA-C domain; Region: TrkA_C; pfam02080 1001582003402 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1001582003403 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1001582003404 thiamine phosphate binding site [chemical binding]; other site 1001582003405 active site 1001582003406 pyrophosphate binding site [ion binding]; other site 1001582003407 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1001582003408 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001582003409 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1001582003410 thiS-thiF/thiG interaction site; other site 1001582003411 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1001582003412 ThiS interaction site; other site 1001582003413 putative active site [active] 1001582003414 tetramer interface [polypeptide binding]; other site 1001582003415 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1001582003416 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1001582003417 ATP binding site [chemical binding]; other site 1001582003418 substrate interface [chemical binding]; other site 1001582003419 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1001582003420 dimer interface [polypeptide binding]; other site 1001582003421 substrate binding site [chemical binding]; other site 1001582003422 ATP binding site [chemical binding]; other site 1001582003423 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1001582003424 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1001582003425 NAD binding site [chemical binding]; other site 1001582003426 homotetramer interface [polypeptide binding]; other site 1001582003427 homodimer interface [polypeptide binding]; other site 1001582003428 substrate binding site [chemical binding]; other site 1001582003429 active site 1001582003430 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1001582003431 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1001582003432 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1001582003433 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1001582003434 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1001582003435 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1001582003436 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1001582003437 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1001582003438 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1001582003439 Part of AAA domain; Region: AAA_19; pfam13245 1001582003440 Family description; Region: UvrD_C_2; pfam13538 1001582003441 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1001582003442 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1001582003443 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1001582003444 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1001582003445 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1001582003446 Walker A/P-loop; other site 1001582003447 ATP binding site [chemical binding]; other site 1001582003448 Q-loop/lid; other site 1001582003449 ABC transporter signature motif; other site 1001582003450 Walker B; other site 1001582003451 D-loop; other site 1001582003452 H-loop/switch region; other site 1001582003453 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1001582003454 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1001582003455 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1001582003456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582003457 Coenzyme A binding pocket [chemical binding]; other site 1001582003458 hypothetical protein; Provisional; Region: PRK13679 1001582003459 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1001582003460 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1001582003461 Putative esterase; Region: Esterase; pfam00756 1001582003462 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1001582003463 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1001582003464 homodimer interface [polypeptide binding]; other site 1001582003465 substrate-cofactor binding pocket; other site 1001582003466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582003467 catalytic residue [active] 1001582003468 cystathionine beta-lyase; Provisional; Region: PRK08064 1001582003469 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1001582003470 homodimer interface [polypeptide binding]; other site 1001582003471 substrate-cofactor binding pocket; other site 1001582003472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582003473 catalytic residue [active] 1001582003474 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1001582003475 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1001582003476 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1001582003477 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1001582003478 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1001582003479 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1001582003480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582003481 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1001582003482 Coenzyme A binding pocket [chemical binding]; other site 1001582003483 YolD-like protein; Region: YolD; pfam08863 1001582003484 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 1001582003485 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1001582003486 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1001582003487 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1001582003488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582003489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582003490 putative substrate translocation pore; other site 1001582003491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582003492 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582003493 putative Zn2+ binding site [ion binding]; other site 1001582003494 putative DNA binding site [nucleotide binding]; other site 1001582003495 dimerization interface [polypeptide binding]; other site 1001582003496 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1001582003497 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1001582003498 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1001582003499 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1001582003500 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 1001582003501 active site 1001582003502 P-loop; other site 1001582003503 phosphorylation site [posttranslational modification] 1001582003504 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1001582003505 methionine cluster; other site 1001582003506 active site 1001582003507 phosphorylation site [posttranslational modification] 1001582003508 metal binding site [ion binding]; metal-binding site 1001582003509 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1001582003510 beta-galactosidase; Region: BGL; TIGR03356 1001582003511 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1001582003512 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1001582003513 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1001582003514 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1001582003515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582003516 motif II; other site 1001582003517 hypothetical protein; Provisional; Region: PRK09272 1001582003518 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582003519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582003520 putative DNA binding site [nucleotide binding]; other site 1001582003521 putative Zn2+ binding site [ion binding]; other site 1001582003522 MgtC family; Region: MgtC; pfam02308 1001582003523 Putative motility protein; Region: YjfB_motility; pfam14070 1001582003524 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1001582003525 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1001582003526 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1001582003527 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1001582003528 catalytic loop [active] 1001582003529 iron binding site [ion binding]; other site 1001582003530 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 1001582003531 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1001582003532 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1001582003533 [4Fe-4S] binding site [ion binding]; other site 1001582003534 molybdopterin cofactor binding site; other site 1001582003535 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1001582003536 molybdopterin cofactor binding site; other site 1001582003537 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1001582003538 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1001582003539 Cytochrome P450; Region: p450; cl12078 1001582003540 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1001582003541 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1001582003542 active site 1001582003543 TDP-binding site; other site 1001582003544 acceptor substrate-binding pocket; other site 1001582003545 homodimer interface [polypeptide binding]; other site 1001582003546 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1001582003547 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1001582003548 active site 1001582003549 TIGR00245 family protein; Region: TIGR00245 1001582003550 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 1001582003551 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1001582003552 Walker A/P-loop; other site 1001582003553 ATP binding site [chemical binding]; other site 1001582003554 Q-loop/lid; other site 1001582003555 ABC transporter signature motif; other site 1001582003556 Walker B; other site 1001582003557 D-loop; other site 1001582003558 H-loop/switch region; other site 1001582003559 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1001582003560 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1001582003561 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1001582003562 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1001582003563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001582003564 Glucuronate isomerase; Region: UxaC; cl00829 1001582003565 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1001582003566 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001582003567 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001582003568 DNA binding site [nucleotide binding] 1001582003569 domain linker motif; other site 1001582003570 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1001582003571 dimerization interface [polypeptide binding]; other site 1001582003572 ligand binding site [chemical binding]; other site 1001582003573 altronate oxidoreductase; Provisional; Region: PRK03643 1001582003574 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1001582003575 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001582003576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582003577 active site 1001582003578 phosphorylation site [posttranslational modification] 1001582003579 intermolecular recognition site; other site 1001582003580 dimerization interface [polypeptide binding]; other site 1001582003581 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001582003582 DNA binding site [nucleotide binding] 1001582003583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001582003584 HAMP domain; Region: HAMP; pfam00672 1001582003585 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582003586 dimer interface [polypeptide binding]; other site 1001582003587 phosphorylation site [posttranslational modification] 1001582003588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582003589 ATP binding site [chemical binding]; other site 1001582003590 Mg2+ binding site [ion binding]; other site 1001582003591 G-X-G motif; other site 1001582003592 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1001582003593 DinB family; Region: DinB; cl17821 1001582003594 DinB superfamily; Region: DinB_2; pfam12867 1001582003595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582003596 binding surface 1001582003597 TPR motif; other site 1001582003598 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582003599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1001582003600 binding surface 1001582003601 TPR motif; other site 1001582003602 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1001582003603 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1001582003604 amidase catalytic site [active] 1001582003605 Zn binding residues [ion binding]; other site 1001582003606 substrate binding site [chemical binding]; other site 1001582003607 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1001582003608 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582003609 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1001582003610 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1001582003611 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1001582003612 pentamer interface [polypeptide binding]; other site 1001582003613 dodecaamer interface [polypeptide binding]; other site 1001582003614 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1001582003615 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1001582003616 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001582003617 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582003618 non-specific DNA binding site [nucleotide binding]; other site 1001582003619 salt bridge; other site 1001582003620 sequence-specific DNA binding site [nucleotide binding]; other site 1001582003621 hypothetical protein; Provisional; Region: PRK06921 1001582003622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582003623 Walker A motif; other site 1001582003624 ATP binding site [chemical binding]; other site 1001582003625 Walker B motif; other site 1001582003626 positive control sigma-like factor; Validated; Region: PRK06930 1001582003627 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582003628 DNA binding residues [nucleotide binding] 1001582003629 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1001582003630 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1001582003631 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 1001582003632 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 1001582003633 Phage capsid family; Region: Phage_capsid; pfam05065 1001582003634 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1001582003635 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1001582003636 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1001582003637 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1001582003638 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1001582003639 Phage XkdN-like protein; Region: XkdN; pfam08890 1001582003640 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1001582003641 AAA ATPase domain; Region: AAA_15; pfam13175 1001582003642 membrane protein P6; Region: PHA01399 1001582003643 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1001582003644 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1001582003645 catalytic residue [active] 1001582003646 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1001582003647 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582003648 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1001582003649 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1001582003650 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1001582003651 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1001582003652 XkdW protein; Region: XkdW; pfam09636 1001582003653 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1001582003654 Haemolysin XhlA; Region: XhlA; pfam10779 1001582003655 Phage lysis protein, holin; Region: Phage_holin; pfam04688 1001582003656 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1001582003657 amidase catalytic site [active] 1001582003658 Zn binding residues [ion binding]; other site 1001582003659 substrate binding site [chemical binding]; other site 1001582003660 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582003661 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1001582003662 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1001582003663 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1001582003664 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1001582003665 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1001582003666 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1001582003667 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1001582003668 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1001582003669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1001582003670 Zn binding site [ion binding]; other site 1001582003671 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1001582003672 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1001582003673 Zn binding site [ion binding]; other site 1001582003674 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1001582003675 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1001582003676 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1001582003677 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1001582003678 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1001582003679 Ligand binding site; other site 1001582003680 Putative Catalytic site; other site 1001582003681 DXD motif; other site 1001582003682 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1001582003683 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1001582003684 protein binding site [polypeptide binding]; other site 1001582003685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582003686 putative substrate translocation pore; other site 1001582003687 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582003688 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1001582003689 SxDxEG motif; other site 1001582003690 active site 1001582003691 metal binding site [ion binding]; metal-binding site 1001582003692 homopentamer interface [polypeptide binding]; other site 1001582003693 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1001582003694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582003695 dimer interface [polypeptide binding]; other site 1001582003696 conserved gate region; other site 1001582003697 putative PBP binding loops; other site 1001582003698 ABC-ATPase subunit interface; other site 1001582003699 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1001582003700 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1001582003701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582003702 dimer interface [polypeptide binding]; other site 1001582003703 conserved gate region; other site 1001582003704 putative PBP binding loops; other site 1001582003705 ABC-ATPase subunit interface; other site 1001582003706 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1001582003707 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1001582003708 Walker A/P-loop; other site 1001582003709 ATP binding site [chemical binding]; other site 1001582003710 Q-loop/lid; other site 1001582003711 ABC transporter signature motif; other site 1001582003712 Walker B; other site 1001582003713 D-loop; other site 1001582003714 H-loop/switch region; other site 1001582003715 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1001582003716 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1001582003717 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1001582003718 peptide binding site [polypeptide binding]; other site 1001582003719 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1001582003720 dimer interface [polypeptide binding]; other site 1001582003721 catalytic triad [active] 1001582003722 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1001582003723 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1001582003724 active site 1001582003725 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1001582003726 NlpC/P60 family; Region: NLPC_P60; pfam00877 1001582003727 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1001582003728 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1001582003729 Walker A/P-loop; other site 1001582003730 ATP binding site [chemical binding]; other site 1001582003731 Q-loop/lid; other site 1001582003732 ABC transporter signature motif; other site 1001582003733 Walker B; other site 1001582003734 D-loop; other site 1001582003735 H-loop/switch region; other site 1001582003736 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1001582003737 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1001582003738 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1001582003739 Amidinotransferase; Region: Amidinotransf; pfam02274 1001582003740 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1001582003741 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1001582003742 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1001582003743 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1001582003744 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1001582003745 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1001582003746 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1001582003747 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1001582003748 putative active site [active] 1001582003749 putative substrate binding site [chemical binding]; other site 1001582003750 putative cosubstrate binding site; other site 1001582003751 catalytic site [active] 1001582003752 gamma-glutamyl kinase; Provisional; Region: PRK05429 1001582003753 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1001582003754 nucleotide binding site [chemical binding]; other site 1001582003755 homotetrameric interface [polypeptide binding]; other site 1001582003756 putative phosphate binding site [ion binding]; other site 1001582003757 putative allosteric binding site; other site 1001582003758 PUA domain; Region: PUA; pfam01472 1001582003759 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1001582003760 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1001582003761 putative catalytic cysteine [active] 1001582003762 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1001582003763 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582003764 MarR family; Region: MarR; pfam01047 1001582003765 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1001582003766 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1001582003767 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1001582003768 putative metal binding site; other site 1001582003769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582003770 binding surface 1001582003771 TPR motif; other site 1001582003772 TPR repeat; Region: TPR_11; pfam13414 1001582003773 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1001582003774 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1001582003775 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1001582003776 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1001582003777 ligand binding site [chemical binding]; other site 1001582003778 flexible hinge region; other site 1001582003779 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1001582003780 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1001582003781 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1001582003782 THF binding site; other site 1001582003783 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1001582003784 substrate binding site [chemical binding]; other site 1001582003785 THF binding site; other site 1001582003786 zinc-binding site [ion binding]; other site 1001582003787 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1001582003788 active site 1001582003789 catalytic residues [active] 1001582003790 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1001582003791 Cobalt transport protein; Region: CbiQ; pfam02361 1001582003792 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1001582003793 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1001582003794 Walker A/P-loop; other site 1001582003795 ATP binding site [chemical binding]; other site 1001582003796 Q-loop/lid; other site 1001582003797 ABC transporter signature motif; other site 1001582003798 Walker B; other site 1001582003799 D-loop; other site 1001582003800 H-loop/switch region; other site 1001582003801 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1001582003802 Walker A/P-loop; other site 1001582003803 ATP binding site [chemical binding]; other site 1001582003804 Q-loop/lid; other site 1001582003805 ABC transporter signature motif; other site 1001582003806 Walker B; other site 1001582003807 D-loop; other site 1001582003808 H-loop/switch region; other site 1001582003809 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1001582003810 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1001582003811 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582003812 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582003813 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1001582003814 active site 1001582003815 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1001582003816 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1001582003817 MgtE intracellular N domain; Region: MgtE_N; smart00924 1001582003818 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1001582003819 Divalent cation transporter; Region: MgtE; pfam01769 1001582003820 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1001582003821 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1001582003822 DNA binding residues [nucleotide binding] 1001582003823 putative dimer interface [polypeptide binding]; other site 1001582003824 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582003825 MarR family; Region: MarR; pfam01047 1001582003826 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1001582003827 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1001582003828 active site 1001582003829 DNA binding site [nucleotide binding] 1001582003830 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1001582003831 nucleotide binding site [chemical binding]; other site 1001582003832 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 1001582003833 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1001582003834 putative DNA binding site [nucleotide binding]; other site 1001582003835 putative homodimer interface [polypeptide binding]; other site 1001582003836 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1001582003837 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1001582003838 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1001582003839 PAS domain; Region: PAS_9; pfam13426 1001582003840 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1001582003841 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1001582003842 metal binding site [ion binding]; metal-binding site 1001582003843 active site 1001582003844 I-site; other site 1001582003845 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1001582003846 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1001582003847 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1001582003848 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1001582003849 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1001582003850 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001582003851 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1001582003852 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1001582003853 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1001582003854 heat shock protein HtpX; Provisional; Region: PRK05457 1001582003855 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1001582003856 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1001582003857 Predicted membrane protein [Function unknown]; Region: COG2323 1001582003858 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1001582003859 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1001582003860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1001582003861 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1001582003862 putative active site [active] 1001582003863 heme pocket [chemical binding]; other site 1001582003864 PAS domain; Region: PAS; smart00091 1001582003865 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1001582003866 PAS domain; Region: PAS; smart00091 1001582003867 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1001582003868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582003869 dimer interface [polypeptide binding]; other site 1001582003870 phosphorylation site [posttranslational modification] 1001582003871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582003872 ATP binding site [chemical binding]; other site 1001582003873 Mg2+ binding site [ion binding]; other site 1001582003874 G-X-G motif; other site 1001582003875 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1001582003876 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1001582003877 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1001582003878 DNA binding site [nucleotide binding] 1001582003879 active site 1001582003880 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1001582003881 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1001582003882 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1001582003883 Phosphotransferase enzyme family; Region: APH; pfam01636 1001582003884 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1001582003885 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1001582003886 putative active site [active] 1001582003887 catalytic triad [active] 1001582003888 putative dimer interface [polypeptide binding]; other site 1001582003889 transaminase; Reviewed; Region: PRK08068 1001582003890 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001582003891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582003892 homodimer interface [polypeptide binding]; other site 1001582003893 catalytic residue [active] 1001582003894 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1001582003895 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1001582003896 dimer interface [polypeptide binding]; other site 1001582003897 active site 1001582003898 catalytic residue [active] 1001582003899 metal binding site [ion binding]; metal-binding site 1001582003900 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1001582003901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582003902 motif II; other site 1001582003903 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1001582003904 intersubunit interface [polypeptide binding]; other site 1001582003905 active site 1001582003906 Zn2+ binding site [ion binding]; other site 1001582003907 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1001582003908 Cupin domain; Region: Cupin_2; pfam07883 1001582003909 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1001582003910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582003911 dimer interface [polypeptide binding]; other site 1001582003912 phosphorylation site [posttranslational modification] 1001582003913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582003914 ATP binding site [chemical binding]; other site 1001582003915 Mg2+ binding site [ion binding]; other site 1001582003916 G-X-G motif; other site 1001582003917 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582003918 MarR family; Region: MarR; pfam01047 1001582003919 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1001582003920 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1001582003921 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1001582003922 ligand binding site [chemical binding]; other site 1001582003923 flagellar motor protein MotA; Validated; Region: PRK08124 1001582003924 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1001582003925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582003926 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1001582003927 Walker A motif; other site 1001582003928 ATP binding site [chemical binding]; other site 1001582003929 Walker B motif; other site 1001582003930 arginine finger; other site 1001582003931 UvrB/uvrC motif; Region: UVR; pfam02151 1001582003932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582003933 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1001582003934 Walker A motif; other site 1001582003935 ATP binding site [chemical binding]; other site 1001582003936 Walker B motif; other site 1001582003937 arginine finger; other site 1001582003938 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1001582003939 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1001582003940 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1001582003941 Ligand Binding Site [chemical binding]; other site 1001582003942 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 1001582003943 active site 1001582003944 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1001582003945 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1001582003946 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1001582003947 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1001582003948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 1001582003949 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1001582003950 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1001582003951 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1001582003952 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1001582003953 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1001582003954 catalytic residues [active] 1001582003955 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1001582003956 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1001582003957 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1001582003958 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1001582003959 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1001582003960 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1001582003961 active site 1001582003962 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001582003963 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001582003964 DNA binding site [nucleotide binding] 1001582003965 domain linker motif; other site 1001582003966 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1001582003967 putative dimerization interface [polypeptide binding]; other site 1001582003968 putative ligand binding site [chemical binding]; other site 1001582003969 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1001582003970 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1001582003971 PRD domain; Region: PRD; pfam00874 1001582003972 PRD domain; Region: PRD; pfam00874 1001582003973 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1001582003974 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1001582003975 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1001582003976 active site turn [active] 1001582003977 phosphorylation site [posttranslational modification] 1001582003978 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1001582003979 HPr interaction site; other site 1001582003980 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1001582003981 active site 1001582003982 phosphorylation site [posttranslational modification] 1001582003983 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1001582003984 dimerization domain swap beta strand [polypeptide binding]; other site 1001582003985 regulatory protein interface [polypeptide binding]; other site 1001582003986 active site 1001582003987 regulatory phosphorylation site [posttranslational modification]; other site 1001582003988 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1001582003989 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1001582003990 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1001582003991 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1001582003992 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1001582003993 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1001582003994 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001582003995 FeS/SAM binding site; other site 1001582003996 Cache domain; Region: Cache_1; pfam02743 1001582003997 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1001582003998 dimerization interface [polypeptide binding]; other site 1001582003999 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1001582004000 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1001582004001 dimer interface [polypeptide binding]; other site 1001582004002 putative CheW interface [polypeptide binding]; other site 1001582004003 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1001582004004 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1001582004005 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1001582004006 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1001582004007 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1001582004008 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1001582004009 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1001582004010 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1001582004011 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1001582004012 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1001582004013 putative active site [active] 1001582004014 heme pocket [chemical binding]; other site 1001582004015 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1001582004016 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1001582004017 putative active site [active] 1001582004018 heme pocket [chemical binding]; other site 1001582004019 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1001582004020 putative active site [active] 1001582004021 heme pocket [chemical binding]; other site 1001582004022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582004023 dimer interface [polypeptide binding]; other site 1001582004024 phosphorylation site [posttranslational modification] 1001582004025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582004026 ATP binding site [chemical binding]; other site 1001582004027 Mg2+ binding site [ion binding]; other site 1001582004028 G-X-G motif; other site 1001582004029 aminotransferase A; Validated; Region: PRK07683 1001582004030 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001582004031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582004032 homodimer interface [polypeptide binding]; other site 1001582004033 catalytic residue [active] 1001582004034 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1001582004035 putative CheA interaction surface; other site 1001582004036 Response regulator receiver domain; Region: Response_reg; pfam00072 1001582004037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582004038 active site 1001582004039 phosphorylation site [posttranslational modification] 1001582004040 intermolecular recognition site; other site 1001582004041 dimerization interface [polypeptide binding]; other site 1001582004042 YkyB-like protein; Region: YkyB; pfam14177 1001582004043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582004044 H+ Antiporter protein; Region: 2A0121; TIGR00900 1001582004045 putative substrate translocation pore; other site 1001582004046 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582004047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1001582004048 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1001582004049 phosphodiesterase YaeI; Provisional; Region: PRK11340 1001582004050 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1001582004051 putative active site [active] 1001582004052 putative metal binding site [ion binding]; other site 1001582004053 short chain dehydrogenase; Provisional; Region: PRK07677 1001582004054 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1001582004055 NAD(P) binding site [chemical binding]; other site 1001582004056 substrate binding site [chemical binding]; other site 1001582004057 homotetramer interface [polypeptide binding]; other site 1001582004058 active site 1001582004059 homodimer interface [polypeptide binding]; other site 1001582004060 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1001582004061 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1001582004062 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1001582004063 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1001582004064 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1001582004065 FOG: CBS domain [General function prediction only]; Region: COG0517 1001582004066 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1001582004067 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001582004068 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001582004069 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1001582004070 dimerization interface [polypeptide binding]; other site 1001582004071 flavodoxin; Provisional; Region: PRK06703 1001582004072 BNR repeat-like domain; Region: BNR_2; pfam13088 1001582004073 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1001582004074 flavodoxin, short chain; Region: flav_short; TIGR01753 1001582004075 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1001582004076 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1001582004077 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1001582004078 active site 1001582004079 trimer interface [polypeptide binding]; other site 1001582004080 substrate binding site [chemical binding]; other site 1001582004081 CoA binding site [chemical binding]; other site 1001582004082 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1001582004083 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1001582004084 metal binding site [ion binding]; metal-binding site 1001582004085 putative dimer interface [polypeptide binding]; other site 1001582004086 hypothetical protein; Provisional; Region: PRK03094 1001582004087 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1001582004088 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1001582004089 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1001582004090 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1001582004091 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1001582004092 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1001582004093 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1001582004094 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1001582004095 GTP binding site; other site 1001582004096 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1001582004097 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1001582004098 ATP binding site [chemical binding]; other site 1001582004099 substrate interface [chemical binding]; other site 1001582004100 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1001582004101 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1001582004102 dimer interface [polypeptide binding]; other site 1001582004103 putative functional site; other site 1001582004104 putative MPT binding site; other site 1001582004105 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1001582004106 Walker A motif; other site 1001582004107 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1001582004108 MoaE homodimer interface [polypeptide binding]; other site 1001582004109 MoaD interaction [polypeptide binding]; other site 1001582004110 active site residues [active] 1001582004111 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1001582004112 MoaE interaction surface [polypeptide binding]; other site 1001582004113 MoeB interaction surface [polypeptide binding]; other site 1001582004114 thiocarboxylated glycine; other site 1001582004115 Yip1 domain; Region: Yip1; pfam04893 1001582004116 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1001582004117 HlyD family secretion protein; Region: HlyD_3; pfam13437 1001582004118 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1001582004119 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1001582004120 Walker A/P-loop; other site 1001582004121 ATP binding site [chemical binding]; other site 1001582004122 Q-loop/lid; other site 1001582004123 ABC transporter signature motif; other site 1001582004124 Walker B; other site 1001582004125 D-loop; other site 1001582004126 H-loop/switch region; other site 1001582004127 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1001582004128 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1001582004129 FtsX-like permease family; Region: FtsX; pfam02687 1001582004130 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1001582004131 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1001582004132 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1001582004133 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1001582004134 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1001582004135 putative substrate binding site [chemical binding]; other site 1001582004136 putative ATP binding site [chemical binding]; other site 1001582004137 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1001582004138 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1001582004139 active site 1001582004140 phosphorylation site [posttranslational modification] 1001582004141 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1001582004142 active site 1001582004143 P-loop; other site 1001582004144 phosphorylation site [posttranslational modification] 1001582004145 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1001582004146 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1001582004147 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1001582004148 Catalytic site [active] 1001582004149 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1001582004150 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001582004151 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001582004152 ABC transporter; Region: ABC_tran_2; pfam12848 1001582004153 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1001582004154 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1001582004155 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1001582004156 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1001582004157 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1001582004158 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1001582004159 rod-share determining protein MreBH; Provisional; Region: PRK13929 1001582004160 MreB and similar proteins; Region: MreB_like; cd10225 1001582004161 nucleotide binding site [chemical binding]; other site 1001582004162 Mg binding site [ion binding]; other site 1001582004163 putative protofilament interaction site [polypeptide binding]; other site 1001582004164 RodZ interaction site [polypeptide binding]; other site 1001582004165 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1001582004166 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1001582004167 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1001582004168 PAS fold; Region: PAS; pfam00989 1001582004169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1001582004170 putative active site [active] 1001582004171 heme pocket [chemical binding]; other site 1001582004172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001582004173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582004174 dimer interface [polypeptide binding]; other site 1001582004175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582004176 ATP binding site [chemical binding]; other site 1001582004177 Mg2+ binding site [ion binding]; other site 1001582004178 G-X-G motif; other site 1001582004179 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1001582004180 putative active site pocket [active] 1001582004181 dimerization interface [polypeptide binding]; other site 1001582004182 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1001582004183 putative active site pocket [active] 1001582004184 dimerization interface [polypeptide binding]; other site 1001582004185 putative catalytic residue [active] 1001582004186 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1001582004187 TrkA-N domain; Region: TrkA_N; pfam02254 1001582004188 TrkA-C domain; Region: TrkA_C; pfam02080 1001582004189 adenine deaminase; Region: ade; TIGR01178 1001582004190 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1001582004191 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1001582004192 active site 1001582004193 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1001582004194 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1001582004195 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1001582004196 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1001582004197 hypothetical protein; Provisional; Region: PRK13667 1001582004198 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Region: PLN02475 1001582004199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1001582004200 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1001582004201 motif II; other site 1001582004202 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582004203 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1001582004204 active site 1001582004205 catalytic residues [active] 1001582004206 metal binding site [ion binding]; metal-binding site 1001582004207 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1001582004208 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1001582004209 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1001582004210 TPP-binding site [chemical binding]; other site 1001582004211 tetramer interface [polypeptide binding]; other site 1001582004212 heterodimer interface [polypeptide binding]; other site 1001582004213 phosphorylation loop region [posttranslational modification] 1001582004214 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1001582004215 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1001582004216 alpha subunit interface [polypeptide binding]; other site 1001582004217 TPP binding site [chemical binding]; other site 1001582004218 heterodimer interface [polypeptide binding]; other site 1001582004219 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1001582004220 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1001582004221 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1001582004222 E3 interaction surface; other site 1001582004223 lipoyl attachment site [posttranslational modification]; other site 1001582004224 e3 binding domain; Region: E3_binding; pfam02817 1001582004225 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1001582004226 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1001582004227 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1001582004228 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001582004229 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1001582004230 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1001582004231 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1001582004232 NodB motif; other site 1001582004233 active site 1001582004234 catalytic site [active] 1001582004235 metal binding site [ion binding]; metal-binding site 1001582004236 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1001582004237 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1001582004238 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1001582004239 homodimer interface [polypeptide binding]; other site 1001582004240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582004241 catalytic residue [active] 1001582004242 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1001582004243 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1001582004244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1001582004245 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1001582004246 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1001582004247 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1001582004248 active site 1001582004249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582004250 Coenzyme A binding pocket [chemical binding]; other site 1001582004251 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1001582004252 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1001582004253 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1001582004254 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1001582004255 active site 1001582004256 Zn binding site [ion binding]; other site 1001582004257 Putative zinc-finger; Region: zf-HC2; pfam13490 1001582004258 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1001582004259 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1001582004260 G1 box; other site 1001582004261 putative GEF interaction site [polypeptide binding]; other site 1001582004262 GTP/Mg2+ binding site [chemical binding]; other site 1001582004263 Switch I region; other site 1001582004264 G2 box; other site 1001582004265 G3 box; other site 1001582004266 Switch II region; other site 1001582004267 G4 box; other site 1001582004268 G5 box; other site 1001582004269 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1001582004270 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1001582004271 YlaH-like protein; Region: YlaH; pfam14036 1001582004272 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1001582004273 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1001582004274 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1001582004275 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1001582004276 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1001582004277 putative active site [active] 1001582004278 PhoH-like protein; Region: PhoH; pfam02562 1001582004279 Glutaminase; Region: Glutaminase; cl00907 1001582004280 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1001582004281 Nucleopolyhedrovirus P10 protein; Region: NPV_P10; cl17484 1001582004282 Helix-turn-helix domain; Region: HTH_17; pfam12728 1001582004283 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1001582004284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582004285 binding surface 1001582004286 TPR motif; other site 1001582004287 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582004288 Short C-terminal domain; Region: SHOCT; pfam09851 1001582004289 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1001582004290 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1001582004291 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 1001582004292 GIY-YIG motif/motif A; other site 1001582004293 putative active site [active] 1001582004294 catalytic site [active] 1001582004295 putative metal binding site [ion binding]; other site 1001582004296 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1001582004297 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1001582004298 active site 1001582004299 DNA binding site [nucleotide binding] 1001582004300 Int/Topo IB signature motif; other site 1001582004301 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1001582004302 HNH endonuclease; Region: HNH_3; pfam13392 1001582004303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1001582004304 non-specific DNA binding site [nucleotide binding]; other site 1001582004305 sequence-specific DNA binding site [nucleotide binding]; other site 1001582004306 salt bridge; other site 1001582004307 RNA dependent RNA polymerase; Region: RdRP; pfam05183 1001582004308 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1001582004309 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1001582004310 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1001582004311 catalytic residues [active] 1001582004312 catalytic nucleophile [active] 1001582004313 Recombinase; Region: Recombinase; pfam07508 1001582004314 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1001582004315 glutaminase A; Region: Gln_ase; TIGR03814 1001582004316 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1001582004317 hypothetical protein; Provisional; Region: PRK13666 1001582004318 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1001582004319 pyruvate carboxylase; Reviewed; Region: PRK12999 1001582004320 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1001582004321 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1001582004322 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1001582004323 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1001582004324 active site 1001582004325 catalytic residues [active] 1001582004326 metal binding site [ion binding]; metal-binding site 1001582004327 homodimer binding site [polypeptide binding]; other site 1001582004328 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1001582004329 carboxyltransferase (CT) interaction site; other site 1001582004330 biotinylation site [posttranslational modification]; other site 1001582004331 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1001582004332 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1001582004333 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1001582004334 UbiA prenyltransferase family; Region: UbiA; pfam01040 1001582004335 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1001582004336 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1001582004337 Cytochrome c; Region: Cytochrom_C; pfam00034 1001582004338 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1001582004339 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1001582004340 D-pathway; other site 1001582004341 Putative ubiquinol binding site [chemical binding]; other site 1001582004342 Low-spin heme (heme b) binding site [chemical binding]; other site 1001582004343 Putative water exit pathway; other site 1001582004344 Binuclear center (heme o3/CuB) [ion binding]; other site 1001582004345 K-pathway; other site 1001582004346 Putative proton exit pathway; other site 1001582004347 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1001582004348 Subunit I/III interface [polypeptide binding]; other site 1001582004349 Subunit III/IV interface [polypeptide binding]; other site 1001582004350 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 1001582004351 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1001582004352 YugN-like family; Region: YugN; pfam08868 1001582004353 FOG: CBS domain [General function prediction only]; Region: COG0517 1001582004354 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1001582004355 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1001582004356 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1001582004357 Putative coat protein; Region: YlbD_coat; pfam14071 1001582004358 YlbE-like protein; Region: YlbE; pfam14003 1001582004359 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1001582004360 hypothetical protein; Provisional; Region: PRK02886 1001582004361 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1001582004362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582004363 S-adenosylmethionine binding site [chemical binding]; other site 1001582004364 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1001582004365 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1001582004366 active site 1001582004367 (T/H)XGH motif; other site 1001582004368 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1001582004369 Nucleoside recognition; Region: Gate; pfam07670 1001582004370 Nucleoside recognition; Region: Gate; pfam07670 1001582004371 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1001582004372 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1001582004373 active site 1001582004374 nucleophile elbow; other site 1001582004375 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1001582004376 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1001582004377 protein binding site [polypeptide binding]; other site 1001582004378 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1001582004379 hypothetical protein; Provisional; Region: PRK13670 1001582004380 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1001582004381 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1001582004382 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1001582004383 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1001582004384 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1001582004385 hypothetical protein; Provisional; Region: PRK13688 1001582004386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582004387 Coenzyme A binding pocket [chemical binding]; other site 1001582004388 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1001582004389 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1001582004390 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1001582004391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1001582004392 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 1001582004393 mraZ protein; Region: TIGR00242 1001582004394 MraZ protein; Region: MraZ; pfam02381 1001582004395 MraZ protein; Region: MraZ; pfam02381 1001582004396 MraW methylase family; Region: Methyltransf_5; pfam01795 1001582004397 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1001582004398 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1001582004399 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1001582004400 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1001582004401 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1001582004402 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1001582004403 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1001582004404 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1001582004405 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1001582004406 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1001582004407 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1001582004408 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1001582004409 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1001582004410 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001582004411 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001582004412 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1001582004413 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1001582004414 Mg++ binding site [ion binding]; other site 1001582004415 putative catalytic motif [active] 1001582004416 putative substrate binding site [chemical binding]; other site 1001582004417 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1001582004418 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001582004419 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001582004420 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1001582004421 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1001582004422 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1001582004423 active site 1001582004424 homodimer interface [polypeptide binding]; other site 1001582004425 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1001582004426 FAD binding domain; Region: FAD_binding_4; pfam01565 1001582004427 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1001582004428 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1001582004429 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1001582004430 Cell division protein FtsQ; Region: FtsQ; pfam03799 1001582004431 cell division protein FtsA; Region: ftsA; TIGR01174 1001582004432 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1001582004433 nucleotide binding site [chemical binding]; other site 1001582004434 Cell division protein FtsA; Region: FtsA; pfam14450 1001582004435 cell division protein FtsZ; Validated; Region: PRK09330 1001582004436 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1001582004437 nucleotide binding site [chemical binding]; other site 1001582004438 SulA interaction site; other site 1001582004439 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1001582004440 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1001582004441 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1001582004442 active site 1001582004443 catalytic triad [active] 1001582004444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1001582004445 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1001582004446 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1001582004447 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1001582004448 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 1001582004449 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1001582004450 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1001582004451 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1001582004452 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001582004453 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582004454 DNA binding residues [nucleotide binding] 1001582004455 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1001582004456 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001582004457 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1001582004458 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582004459 DNA binding residues [nucleotide binding] 1001582004460 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1001582004461 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1001582004462 Walker A/P-loop; other site 1001582004463 ATP binding site [chemical binding]; other site 1001582004464 Q-loop/lid; other site 1001582004465 ABC transporter signature motif; other site 1001582004466 Walker B; other site 1001582004467 D-loop; other site 1001582004468 H-loop/switch region; other site 1001582004469 acetylornithine deacetylase; Validated; Region: PRK08596 1001582004470 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1001582004471 metal binding site [ion binding]; metal-binding site 1001582004472 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1001582004473 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1001582004474 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1001582004475 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1001582004476 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1001582004477 catalytic residue [active] 1001582004478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1001582004479 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1001582004480 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001582004481 RNA binding surface [nucleotide binding]; other site 1001582004482 DivIVA protein; Region: DivIVA; pfam05103 1001582004483 DivIVA domain; Region: DivI1A_domain; TIGR03544 1001582004484 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1001582004485 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1001582004486 HIGH motif; other site 1001582004487 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1001582004488 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1001582004489 active site 1001582004490 KMSKS motif; other site 1001582004491 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1001582004492 tRNA binding surface [nucleotide binding]; other site 1001582004493 anticodon binding site; other site 1001582004494 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1001582004495 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1001582004496 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1001582004497 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001582004498 RNA binding surface [nucleotide binding]; other site 1001582004499 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1001582004500 active site 1001582004501 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1001582004502 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001582004503 active site 1001582004504 uracil-xanthine permease; Region: ncs2; TIGR00801 1001582004505 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1001582004506 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1001582004507 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1001582004508 dihydroorotase; Validated; Region: pyrC; PRK09357 1001582004509 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1001582004510 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1001582004511 active site 1001582004512 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1001582004513 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1001582004514 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1001582004515 catalytic site [active] 1001582004516 subunit interface [polypeptide binding]; other site 1001582004517 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1001582004518 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1001582004519 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1001582004520 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1001582004521 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1001582004522 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1001582004523 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1001582004524 IMP binding site; other site 1001582004525 dimer interface [polypeptide binding]; other site 1001582004526 interdomain contacts; other site 1001582004527 partial ornithine binding site; other site 1001582004528 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1001582004529 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1001582004530 FAD binding pocket [chemical binding]; other site 1001582004531 FAD binding motif [chemical binding]; other site 1001582004532 phosphate binding motif [ion binding]; other site 1001582004533 beta-alpha-beta structure motif; other site 1001582004534 NAD binding pocket [chemical binding]; other site 1001582004535 Iron coordination center [ion binding]; other site 1001582004536 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1001582004537 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1001582004538 heterodimer interface [polypeptide binding]; other site 1001582004539 active site 1001582004540 FMN binding site [chemical binding]; other site 1001582004541 homodimer interface [polypeptide binding]; other site 1001582004542 substrate binding site [chemical binding]; other site 1001582004543 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1001582004544 active site 1001582004545 dimer interface [polypeptide binding]; other site 1001582004546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001582004547 active site 1001582004548 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1001582004549 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1001582004550 Active Sites [active] 1001582004551 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1001582004552 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1001582004553 ATP-sulfurylase; Region: ATPS; cd00517 1001582004554 active site 1001582004555 HXXH motif; other site 1001582004556 flexible loop; other site 1001582004557 AAA domain; Region: AAA_33; pfam13671 1001582004558 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1001582004559 ligand-binding site [chemical binding]; other site 1001582004560 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1001582004561 diphthine synthase; Region: dph5; TIGR00522 1001582004562 active site 1001582004563 SAM binding site [chemical binding]; other site 1001582004564 homodimer interface [polypeptide binding]; other site 1001582004565 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1001582004566 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1001582004567 putative active site [active] 1001582004568 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1001582004569 putative active site [active] 1001582004570 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1001582004571 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1001582004572 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1001582004573 active site 1001582004574 Na/Ca binding site [ion binding]; other site 1001582004575 catalytic site [active] 1001582004576 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 1001582004577 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1001582004578 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1001582004579 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1001582004580 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1001582004581 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1001582004582 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1001582004583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582004584 motif II; other site 1001582004585 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1001582004586 TIGR00255 family protein; Region: TIGR00255 1001582004587 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1001582004588 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1001582004589 hypothetical protein; Provisional; Region: PRK04323 1001582004590 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1001582004591 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1001582004592 catalytic site [active] 1001582004593 G-X2-G-X-G-K; other site 1001582004594 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1001582004595 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1001582004596 Flavoprotein; Region: Flavoprotein; pfam02441 1001582004597 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1001582004598 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1001582004599 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001582004600 ATP binding site [chemical binding]; other site 1001582004601 putative Mg++ binding site [ion binding]; other site 1001582004602 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001582004603 nucleotide binding region [chemical binding]; other site 1001582004604 ATP-binding site [chemical binding]; other site 1001582004605 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1001582004606 active site 1001582004607 catalytic residues [active] 1001582004608 metal binding site [ion binding]; metal-binding site 1001582004609 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1001582004610 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1001582004611 putative active site [active] 1001582004612 substrate binding site [chemical binding]; other site 1001582004613 putative cosubstrate binding site; other site 1001582004614 catalytic site [active] 1001582004615 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1001582004616 substrate binding site [chemical binding]; other site 1001582004617 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1001582004618 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1001582004619 putative RNA binding site [nucleotide binding]; other site 1001582004620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582004621 S-adenosylmethionine binding site [chemical binding]; other site 1001582004622 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1001582004623 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001582004624 FeS/SAM binding site; other site 1001582004625 Protein phosphatase 2C; Region: PP2C; pfam00481 1001582004626 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1001582004627 active site 1001582004628 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1001582004629 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1001582004630 active site 1001582004631 ATP binding site [chemical binding]; other site 1001582004632 substrate binding site [chemical binding]; other site 1001582004633 activation loop (A-loop); other site 1001582004634 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1001582004635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1001582004636 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1001582004637 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1001582004638 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1001582004639 GTPase RsgA; Reviewed; Region: PRK00098 1001582004640 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1001582004641 RNA binding site [nucleotide binding]; other site 1001582004642 homodimer interface [polypeptide binding]; other site 1001582004643 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1001582004644 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1001582004645 GTP/Mg2+ binding site [chemical binding]; other site 1001582004646 G4 box; other site 1001582004647 G5 box; other site 1001582004648 G1 box; other site 1001582004649 Switch I region; other site 1001582004650 G2 box; other site 1001582004651 G3 box; other site 1001582004652 Switch II region; other site 1001582004653 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1001582004654 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1001582004655 substrate binding site [chemical binding]; other site 1001582004656 hexamer interface [polypeptide binding]; other site 1001582004657 metal binding site [ion binding]; metal-binding site 1001582004658 Thiamine pyrophosphokinase; Region: TPK; cd07995 1001582004659 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1001582004660 active site 1001582004661 dimerization interface [polypeptide binding]; other site 1001582004662 thiamine binding site [chemical binding]; other site 1001582004663 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 1001582004664 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1001582004665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1001582004666 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1001582004667 DAK2 domain; Region: Dak2; pfam02734 1001582004668 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1001582004669 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1001582004670 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1001582004671 putative L-serine binding site [chemical binding]; other site 1001582004672 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1001582004673 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1001582004674 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1001582004675 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1001582004676 generic binding surface II; other site 1001582004677 ssDNA binding site; other site 1001582004678 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001582004679 ATP binding site [chemical binding]; other site 1001582004680 putative Mg++ binding site [ion binding]; other site 1001582004681 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001582004682 nucleotide binding region [chemical binding]; other site 1001582004683 ATP-binding site [chemical binding]; other site 1001582004684 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1001582004685 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1001582004686 putative phosphate acyltransferase; Provisional; Region: PRK05331 1001582004687 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1001582004688 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1001582004689 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1001582004690 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1001582004691 NAD(P) binding site [chemical binding]; other site 1001582004692 homotetramer interface [polypeptide binding]; other site 1001582004693 homodimer interface [polypeptide binding]; other site 1001582004694 active site 1001582004695 acyl carrier protein; Provisional; Region: acpP; PRK00982 1001582004696 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1001582004697 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1001582004698 dimerization interface [polypeptide binding]; other site 1001582004699 active site 1001582004700 metal binding site [ion binding]; metal-binding site 1001582004701 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1001582004702 dsRNA binding site [nucleotide binding]; other site 1001582004703 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1001582004704 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1001582004705 Walker A/P-loop; other site 1001582004706 ATP binding site [chemical binding]; other site 1001582004707 Q-loop/lid; other site 1001582004708 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1001582004709 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1001582004710 ABC transporter signature motif; other site 1001582004711 Walker B; other site 1001582004712 D-loop; other site 1001582004713 H-loop/switch region; other site 1001582004714 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1001582004715 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1001582004716 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1001582004717 GTP binding site [chemical binding]; other site 1001582004718 putative DNA-binding protein; Validated; Region: PRK00118 1001582004719 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1001582004720 signal recognition particle protein; Provisional; Region: PRK10867 1001582004721 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1001582004722 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1001582004723 P loop; other site 1001582004724 GTP binding site [chemical binding]; other site 1001582004725 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1001582004726 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1001582004727 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1001582004728 KH domain; Region: KH_4; pfam13083 1001582004729 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1001582004730 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1001582004731 RimM N-terminal domain; Region: RimM; pfam01782 1001582004732 PRC-barrel domain; Region: PRC; pfam05239 1001582004733 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1001582004734 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1001582004735 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1001582004736 GTP/Mg2+ binding site [chemical binding]; other site 1001582004737 G4 box; other site 1001582004738 G5 box; other site 1001582004739 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1001582004740 G1 box; other site 1001582004741 G1 box; other site 1001582004742 GTP/Mg2+ binding site [chemical binding]; other site 1001582004743 Switch I region; other site 1001582004744 G2 box; other site 1001582004745 G2 box; other site 1001582004746 G3 box; other site 1001582004747 G3 box; other site 1001582004748 Switch II region; other site 1001582004749 Switch II region; other site 1001582004750 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1001582004751 RNA/DNA hybrid binding site [nucleotide binding]; other site 1001582004752 active site 1001582004753 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1001582004754 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1001582004755 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1001582004756 CoA-ligase; Region: Ligase_CoA; pfam00549 1001582004757 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1001582004758 CoA binding domain; Region: CoA_binding; smart00881 1001582004759 CoA-ligase; Region: Ligase_CoA; pfam00549 1001582004760 DNA protecting protein DprA; Region: dprA; TIGR00732 1001582004761 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1001582004762 DNA topoisomerase I; Validated; Region: PRK05582 1001582004763 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1001582004764 active site 1001582004765 interdomain interaction site; other site 1001582004766 putative metal-binding site [ion binding]; other site 1001582004767 nucleotide binding site [chemical binding]; other site 1001582004768 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1001582004769 domain I; other site 1001582004770 DNA binding groove [nucleotide binding] 1001582004771 phosphate binding site [ion binding]; other site 1001582004772 domain II; other site 1001582004773 domain III; other site 1001582004774 nucleotide binding site [chemical binding]; other site 1001582004775 catalytic site [active] 1001582004776 domain IV; other site 1001582004777 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1001582004778 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1001582004779 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1001582004780 Glucose inhibited division protein A; Region: GIDA; pfam01134 1001582004781 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1001582004782 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1001582004783 active site 1001582004784 Int/Topo IB signature motif; other site 1001582004785 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1001582004786 active site 1001582004787 HslU subunit interaction site [polypeptide binding]; other site 1001582004788 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1001582004789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582004790 Walker A motif; other site 1001582004791 ATP binding site [chemical binding]; other site 1001582004792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1001582004793 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1001582004794 transcriptional repressor CodY; Validated; Region: PRK04158 1001582004795 CodY GAF-like domain; Region: CodY; pfam06018 1001582004796 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1001582004797 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1001582004798 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1001582004799 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1001582004800 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1001582004801 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1001582004802 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1001582004803 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 1001582004804 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1001582004805 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1001582004806 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1001582004807 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1001582004808 MgtE intracellular N domain; Region: MgtE_N; smart00924 1001582004809 FliG C-terminal domain; Region: FliG_C; pfam01706 1001582004810 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 1001582004811 Flagellar assembly protein FliH; Region: FliH; pfam02108 1001582004812 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1001582004813 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1001582004814 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1001582004815 Walker A motif/ATP binding site; other site 1001582004816 Walker B motif; other site 1001582004817 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1001582004818 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1001582004819 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1001582004820 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1001582004821 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1001582004822 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1001582004823 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1001582004824 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1001582004825 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1001582004826 Flagellar protein (FlbD); Region: FlbD; pfam06289 1001582004827 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 1001582004828 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1001582004829 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1001582004830 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1001582004831 flagellar motor switch protein; Validated; Region: PRK08119 1001582004832 CheC-like family; Region: CheC; pfam04509 1001582004833 CheC-like family; Region: CheC; pfam04509 1001582004834 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1001582004835 Response regulator receiver domain; Region: Response_reg; pfam00072 1001582004836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582004837 active site 1001582004838 phosphorylation site [posttranslational modification] 1001582004839 intermolecular recognition site; other site 1001582004840 dimerization interface [polypeptide binding]; other site 1001582004841 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 1001582004842 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1001582004843 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1001582004844 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1001582004845 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1001582004846 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1001582004847 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1001582004848 FHIPEP family; Region: FHIPEP; pfam00771 1001582004849 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1001582004850 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1001582004851 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1001582004852 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1001582004853 P-loop; other site 1001582004854 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1001582004855 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1001582004856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582004857 active site 1001582004858 phosphorylation site [posttranslational modification] 1001582004859 intermolecular recognition site; other site 1001582004860 dimerization interface [polypeptide binding]; other site 1001582004861 CheB methylesterase; Region: CheB_methylest; pfam01339 1001582004862 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1001582004863 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1001582004864 putative binding surface; other site 1001582004865 active site 1001582004866 P2 response regulator binding domain; Region: P2; pfam07194 1001582004867 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1001582004868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582004869 ATP binding site [chemical binding]; other site 1001582004870 Mg2+ binding site [ion binding]; other site 1001582004871 G-X-G motif; other site 1001582004872 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1001582004873 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1001582004874 putative CheA interaction surface; other site 1001582004875 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1001582004876 CheC-like family; Region: CheC; pfam04509 1001582004877 CheC-like family; Region: CheC; pfam04509 1001582004878 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1001582004879 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1001582004880 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001582004881 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1001582004882 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582004883 DNA binding residues [nucleotide binding] 1001582004884 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1001582004885 rRNA interaction site [nucleotide binding]; other site 1001582004886 S8 interaction site; other site 1001582004887 putative laminin-1 binding site; other site 1001582004888 elongation factor Ts; Provisional; Region: tsf; PRK09377 1001582004889 UBA/TS-N domain; Region: UBA; pfam00627 1001582004890 Elongation factor TS; Region: EF_TS; pfam00889 1001582004891 Elongation factor TS; Region: EF_TS; pfam00889 1001582004892 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1001582004893 putative nucleotide binding site [chemical binding]; other site 1001582004894 uridine monophosphate binding site [chemical binding]; other site 1001582004895 homohexameric interface [polypeptide binding]; other site 1001582004896 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1001582004897 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1001582004898 hinge region; other site 1001582004899 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1001582004900 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1001582004901 catalytic residue [active] 1001582004902 putative FPP diphosphate binding site; other site 1001582004903 putative FPP binding hydrophobic cleft; other site 1001582004904 dimer interface [polypeptide binding]; other site 1001582004905 putative IPP diphosphate binding site; other site 1001582004906 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1001582004907 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1001582004908 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1001582004909 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1001582004910 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1001582004911 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1001582004912 RIP metalloprotease RseP; Region: TIGR00054 1001582004913 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1001582004914 active site 1001582004915 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1001582004916 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1001582004917 protein binding site [polypeptide binding]; other site 1001582004918 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1001582004919 putative substrate binding region [chemical binding]; other site 1001582004920 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1001582004921 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1001582004922 dimer interface [polypeptide binding]; other site 1001582004923 motif 1; other site 1001582004924 active site 1001582004925 motif 2; other site 1001582004926 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1001582004927 putative deacylase active site [active] 1001582004928 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1001582004929 active site 1001582004930 motif 3; other site 1001582004931 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1001582004932 anticodon binding site; other site 1001582004933 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1001582004934 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1001582004935 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1001582004936 generic binding surface II; other site 1001582004937 generic binding surface I; other site 1001582004938 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1001582004939 active site 1001582004940 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1001582004941 active site 1001582004942 catalytic site [active] 1001582004943 substrate binding site [chemical binding]; other site 1001582004944 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1001582004945 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1001582004946 Sm and related proteins; Region: Sm_like; cl00259 1001582004947 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1001582004948 putative oligomer interface [polypeptide binding]; other site 1001582004949 putative RNA binding site [nucleotide binding]; other site 1001582004950 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1001582004951 NusA N-terminal domain; Region: NusA_N; pfam08529 1001582004952 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1001582004953 RNA binding site [nucleotide binding]; other site 1001582004954 homodimer interface [polypeptide binding]; other site 1001582004955 NusA-like KH domain; Region: KH_5; pfam13184 1001582004956 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1001582004957 G-X-X-G motif; other site 1001582004958 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1001582004959 putative RNA binding cleft [nucleotide binding]; other site 1001582004960 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1001582004961 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1001582004962 translation initiation factor IF-2; Region: IF-2; TIGR00487 1001582004963 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1001582004964 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1001582004965 G1 box; other site 1001582004966 putative GEF interaction site [polypeptide binding]; other site 1001582004967 GTP/Mg2+ binding site [chemical binding]; other site 1001582004968 Switch I region; other site 1001582004969 G2 box; other site 1001582004970 G3 box; other site 1001582004971 Switch II region; other site 1001582004972 G4 box; other site 1001582004973 G5 box; other site 1001582004974 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1001582004975 Translation-initiation factor 2; Region: IF-2; pfam11987 1001582004976 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1001582004977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1001582004978 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1001582004979 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1001582004980 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1001582004981 RNA binding site [nucleotide binding]; other site 1001582004982 active site 1001582004983 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1001582004984 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1001582004985 active site 1001582004986 Riboflavin kinase; Region: Flavokinase; smart00904 1001582004987 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1001582004988 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1001582004989 RNase E interface [polypeptide binding]; other site 1001582004990 trimer interface [polypeptide binding]; other site 1001582004991 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1001582004992 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1001582004993 RNase E interface [polypeptide binding]; other site 1001582004994 trimer interface [polypeptide binding]; other site 1001582004995 active site 1001582004996 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1001582004997 putative nucleic acid binding region [nucleotide binding]; other site 1001582004998 G-X-X-G motif; other site 1001582004999 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1001582005000 RNA binding site [nucleotide binding]; other site 1001582005001 domain interface; other site 1001582005002 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1001582005003 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1001582005004 NodB motif; other site 1001582005005 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1001582005006 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1001582005007 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1001582005008 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1001582005009 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1001582005010 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1001582005011 NAD binding site [chemical binding]; other site 1001582005012 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1001582005013 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1001582005014 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1001582005015 aspartate kinase I; Reviewed; Region: PRK08210 1001582005016 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1001582005017 putative catalytic residues [active] 1001582005018 putative nucleotide binding site [chemical binding]; other site 1001582005019 putative aspartate binding site [chemical binding]; other site 1001582005020 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1001582005021 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1001582005022 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1001582005023 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1001582005024 dimer interface [polypeptide binding]; other site 1001582005025 active site 1001582005026 catalytic residue [active] 1001582005027 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1001582005028 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1001582005029 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1001582005030 Clp protease; Region: CLP_protease; pfam00574 1001582005031 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1001582005032 active site 1001582005033 YlzJ-like protein; Region: YlzJ; pfam14035 1001582005034 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1001582005035 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1001582005036 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1001582005037 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1001582005038 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1001582005039 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582005040 DNA-binding site [nucleotide binding]; DNA binding site 1001582005041 UTRA domain; Region: UTRA; pfam07702 1001582005042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582005043 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582005044 putative substrate translocation pore; other site 1001582005045 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582005046 MarR family; Region: MarR_2; pfam12802 1001582005047 MMPL family; Region: MMPL; pfam03176 1001582005048 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1001582005049 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1001582005050 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1001582005051 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1001582005052 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1001582005053 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1001582005054 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1001582005055 classical (c) SDRs; Region: SDR_c; cd05233 1001582005056 NAD(P) binding site [chemical binding]; other site 1001582005057 active site 1001582005058 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1001582005059 ACT domain; Region: ACT; pfam01842 1001582005060 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1001582005061 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1001582005062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582005063 non-specific DNA binding site [nucleotide binding]; other site 1001582005064 salt bridge; other site 1001582005065 sequence-specific DNA binding site [nucleotide binding]; other site 1001582005066 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1001582005067 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1001582005068 competence damage-inducible protein A; Provisional; Region: PRK00549 1001582005069 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1001582005070 putative MPT binding site; other site 1001582005071 Competence-damaged protein; Region: CinA; pfam02464 1001582005072 recombinase A; Provisional; Region: recA; PRK09354 1001582005073 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1001582005074 hexamer interface [polypeptide binding]; other site 1001582005075 Walker A motif; other site 1001582005076 ATP binding site [chemical binding]; other site 1001582005077 Walker B motif; other site 1001582005078 Beta-lactamase; Region: Beta-lactamase; pfam00144 1001582005079 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1001582005080 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1001582005081 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1001582005082 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001582005083 Zn2+ binding site [ion binding]; other site 1001582005084 Mg2+ binding site [ion binding]; other site 1001582005085 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1001582005086 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1001582005087 putative active site [active] 1001582005088 metal binding site [ion binding]; metal-binding site 1001582005089 homodimer binding site [polypeptide binding]; other site 1001582005090 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1001582005091 Threonine dehydrogenase; Region: TDH; cd05281 1001582005092 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1001582005093 structural Zn binding site [ion binding]; other site 1001582005094 catalytic Zn binding site [ion binding]; other site 1001582005095 tetramer interface [polypeptide binding]; other site 1001582005096 NADP binding site [chemical binding]; other site 1001582005097 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1001582005098 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1001582005099 substrate-cofactor binding pocket; other site 1001582005100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582005101 catalytic residue [active] 1001582005102 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1001582005103 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1001582005104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001582005105 FeS/SAM binding site; other site 1001582005106 TRAM domain; Region: TRAM; pfam01938 1001582005107 Predicted membrane protein [Function unknown]; Region: COG4550 1001582005108 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1001582005109 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1001582005110 MutS domain I; Region: MutS_I; pfam01624 1001582005111 MutS domain II; Region: MutS_II; pfam05188 1001582005112 MutS domain III; Region: MutS_III; pfam05192 1001582005113 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1001582005114 Walker A/P-loop; other site 1001582005115 ATP binding site [chemical binding]; other site 1001582005116 Q-loop/lid; other site 1001582005117 ABC transporter signature motif; other site 1001582005118 Walker B; other site 1001582005119 D-loop; other site 1001582005120 H-loop/switch region; other site 1001582005121 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1001582005122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582005123 ATP binding site [chemical binding]; other site 1001582005124 Mg2+ binding site [ion binding]; other site 1001582005125 G-X-G motif; other site 1001582005126 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1001582005127 ATP binding site [chemical binding]; other site 1001582005128 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1001582005129 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1001582005130 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1001582005131 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1001582005132 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1001582005133 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1001582005134 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1001582005135 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1001582005136 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1001582005137 FMN binding site [chemical binding]; other site 1001582005138 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1001582005139 substrate binding site [chemical binding]; other site 1001582005140 putative catalytic residue [active] 1001582005141 acyl carrier protein; Validated; Region: PRK07117 1001582005142 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1001582005143 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1001582005144 dimer interface [polypeptide binding]; other site 1001582005145 active site 1001582005146 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1001582005147 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1001582005148 substrate binding site [chemical binding]; other site 1001582005149 oxyanion hole (OAH) forming residues; other site 1001582005150 trimer interface [polypeptide binding]; other site 1001582005151 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1001582005152 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1001582005153 substrate binding site [chemical binding]; other site 1001582005154 oxyanion hole (OAH) forming residues; other site 1001582005155 trimer interface [polypeptide binding]; other site 1001582005156 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 1001582005157 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1001582005158 acyl-activating enzyme (AAE) consensus motif; other site 1001582005159 putative AMP binding site [chemical binding]; other site 1001582005160 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005161 Condensation domain; Region: Condensation; pfam00668 1001582005162 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582005163 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1001582005164 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1001582005165 acyl-activating enzyme (AAE) consensus motif; other site 1001582005166 AMP binding site [chemical binding]; other site 1001582005167 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005168 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1001582005169 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1001582005170 active site 1001582005171 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1001582005172 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1001582005173 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1001582005174 putative NADP binding site [chemical binding]; other site 1001582005175 active site 1001582005176 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1001582005177 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1001582005178 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1001582005179 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1001582005180 active site 1001582005181 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1001582005182 putative NADP binding site [chemical binding]; other site 1001582005183 active site 1001582005184 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005185 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1001582005186 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1001582005187 active site 1001582005188 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1001582005189 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1001582005190 active site 1001582005191 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1001582005192 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1001582005193 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1001582005194 putative NADP binding site [chemical binding]; other site 1001582005195 active site 1001582005196 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1001582005197 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1001582005198 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1001582005199 active site 1001582005200 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1001582005201 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1001582005202 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1001582005203 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1001582005204 active site 1001582005205 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1001582005206 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1001582005207 putative NADP binding site [chemical binding]; other site 1001582005208 active site 1001582005209 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005210 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1001582005211 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1001582005212 active site 1001582005213 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1001582005214 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005215 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1001582005216 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1001582005217 active site 1001582005218 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1001582005219 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1001582005220 putative NADP binding site [chemical binding]; other site 1001582005221 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1001582005222 active site 1001582005223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582005224 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1001582005225 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1001582005226 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1001582005227 active site 1001582005228 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1001582005229 putative NADP binding site [chemical binding]; other site 1001582005230 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1001582005231 active site 1001582005232 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005233 Condensation domain; Region: Condensation; pfam00668 1001582005234 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582005235 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1001582005236 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1001582005237 acyl-activating enzyme (AAE) consensus motif; other site 1001582005238 AMP binding site [chemical binding]; other site 1001582005239 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005240 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1001582005241 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1001582005242 active site 1001582005243 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1001582005244 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1001582005245 putative NADP binding site [chemical binding]; other site 1001582005246 KR domain; Region: KR; pfam08659 1001582005247 active site 1001582005248 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1001582005249 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1001582005250 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1001582005251 active site 1001582005252 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1001582005253 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1001582005254 putative NADP binding site [chemical binding]; other site 1001582005255 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1001582005256 active site 1001582005257 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1001582005258 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1001582005259 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1001582005260 active site 1001582005261 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1001582005262 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1001582005263 putative NADP binding site [chemical binding]; other site 1001582005264 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1001582005265 active site 1001582005266 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1001582005267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582005268 S-adenosylmethionine binding site [chemical binding]; other site 1001582005269 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1001582005270 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1001582005271 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1001582005272 active site 1001582005273 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1001582005274 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1001582005275 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1001582005276 active site 1001582005277 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005278 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1001582005279 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1001582005280 Cytochrome P450; Region: p450; cl12078 1001582005281 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1001582005282 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1001582005283 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1001582005284 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1001582005285 active site 1001582005286 catalytic triad [active] 1001582005287 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1001582005288 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1001582005289 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1001582005290 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1001582005291 YmaF family; Region: YmaF; pfam12788 1001582005292 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1001582005293 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1001582005294 bacterial Hfq-like; Region: Hfq; cd01716 1001582005295 hexamer interface [polypeptide binding]; other site 1001582005296 Sm1 motif; other site 1001582005297 RNA binding site [nucleotide binding]; other site 1001582005298 Sm2 motif; other site 1001582005299 YmzC-like protein; Region: YmzC; pfam14157 1001582005300 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1001582005301 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1001582005302 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1001582005303 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1001582005304 active site 1001582005305 dimer interface [polypeptide binding]; other site 1001582005306 catalytic residues [active] 1001582005307 effector binding site; other site 1001582005308 R2 peptide binding site; other site 1001582005309 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1001582005310 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1001582005311 dimer interface [polypeptide binding]; other site 1001582005312 putative radical transfer pathway; other site 1001582005313 diiron center [ion binding]; other site 1001582005314 tyrosyl radical; other site 1001582005315 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1001582005316 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1001582005317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582005318 Walker A motif; other site 1001582005319 ATP binding site [chemical binding]; other site 1001582005320 Walker B motif; other site 1001582005321 arginine finger; other site 1001582005322 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1001582005323 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1001582005324 HflX GTPase family; Region: HflX; cd01878 1001582005325 G1 box; other site 1001582005326 GTP/Mg2+ binding site [chemical binding]; other site 1001582005327 Switch I region; other site 1001582005328 G2 box; other site 1001582005329 G3 box; other site 1001582005330 Switch II region; other site 1001582005331 G4 box; other site 1001582005332 G5 box; other site 1001582005333 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1001582005334 Aluminium resistance protein; Region: Alum_res; pfam06838 1001582005335 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1001582005336 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1001582005337 DNA binding residues [nucleotide binding] 1001582005338 putative dimer interface [polypeptide binding]; other site 1001582005339 glutamine synthetase, type I; Region: GlnA; TIGR00653 1001582005340 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1001582005341 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1001582005342 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1001582005343 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1001582005344 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1001582005345 Cytochrome P450; Region: p450; cl12078 1001582005346 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1001582005347 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1001582005348 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1001582005349 inhibitor binding site; inhibition site 1001582005350 active site 1001582005351 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1001582005352 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1001582005353 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1001582005354 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1001582005355 nucleotide binding site [chemical binding]; other site 1001582005356 xylose isomerase; Provisional; Region: PRK05474 1001582005357 xylose isomerase; Region: xylose_isom_A; TIGR02630 1001582005358 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1001582005359 N- and C-terminal domain interface [polypeptide binding]; other site 1001582005360 D-xylulose kinase; Region: XylB; TIGR01312 1001582005361 active site 1001582005362 MgATP binding site [chemical binding]; other site 1001582005363 catalytic site [active] 1001582005364 metal binding site [ion binding]; metal-binding site 1001582005365 xylulose binding site [chemical binding]; other site 1001582005366 homodimer interface [polypeptide binding]; other site 1001582005367 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1001582005368 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1001582005369 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1001582005370 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1001582005371 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1001582005372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582005373 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1001582005374 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1001582005375 putative NAD(P) binding site [chemical binding]; other site 1001582005376 catalytic Zn binding site [ion binding]; other site 1001582005377 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582005378 DinB family; Region: DinB; cl17821 1001582005379 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1001582005380 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1001582005381 NAD binding site [chemical binding]; other site 1001582005382 substrate binding site [chemical binding]; other site 1001582005383 catalytic Zn binding site [ion binding]; other site 1001582005384 tetramer interface [polypeptide binding]; other site 1001582005385 structural Zn binding site [ion binding]; other site 1001582005386 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 1001582005387 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1001582005388 YoaP-like; Region: YoaP; pfam14268 1001582005389 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1001582005390 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1001582005391 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1001582005392 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1001582005393 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1001582005394 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1001582005395 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1001582005396 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1001582005397 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1001582005398 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 1001582005399 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1001582005400 trimer interface [polypeptide binding]; other site 1001582005401 active site 1001582005402 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1001582005403 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1001582005404 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 1001582005405 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1001582005406 LexA repressor; Validated; Region: PRK00215 1001582005407 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582005408 putative DNA binding site [nucleotide binding]; other site 1001582005409 putative Zn2+ binding site [ion binding]; other site 1001582005410 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1001582005411 Catalytic site [active] 1001582005412 cell division suppressor protein YneA; Provisional; Region: PRK14125 1001582005413 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582005414 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1001582005415 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1001582005416 catalytic residues [active] 1001582005417 catalytic nucleophile [active] 1001582005418 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1001582005419 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1001582005420 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1001582005421 TPP-binding site [chemical binding]; other site 1001582005422 dimer interface [polypeptide binding]; other site 1001582005423 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1001582005424 PYR/PP interface [polypeptide binding]; other site 1001582005425 dimer interface [polypeptide binding]; other site 1001582005426 TPP binding site [chemical binding]; other site 1001582005427 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1001582005428 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1001582005429 hypothetical protein; Provisional; Region: PRK01844 1001582005430 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1001582005431 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1001582005432 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1001582005433 Response regulator receiver domain; Region: Response_reg; pfam00072 1001582005434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582005435 active site 1001582005436 phosphorylation site [posttranslational modification] 1001582005437 intermolecular recognition site; other site 1001582005438 dimerization interface [polypeptide binding]; other site 1001582005439 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1001582005440 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1001582005441 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1001582005442 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 1001582005443 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1001582005444 aconitate hydratase; Validated; Region: PRK09277 1001582005445 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1001582005446 substrate binding site [chemical binding]; other site 1001582005447 ligand binding site [chemical binding]; other site 1001582005448 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1001582005449 substrate binding site [chemical binding]; other site 1001582005450 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1001582005451 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1001582005452 catalytic residues [active] 1001582005453 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1001582005454 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1001582005455 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1001582005456 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1001582005457 active site 1001582005458 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1001582005459 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1001582005460 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1001582005461 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1001582005462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582005463 ATP binding site [chemical binding]; other site 1001582005464 Mg2+ binding site [ion binding]; other site 1001582005465 G-X-G motif; other site 1001582005466 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1001582005467 anchoring element; other site 1001582005468 dimer interface [polypeptide binding]; other site 1001582005469 ATP binding site [chemical binding]; other site 1001582005470 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1001582005471 active site 1001582005472 putative metal-binding site [ion binding]; other site 1001582005473 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1001582005474 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1001582005475 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1001582005476 CAP-like domain; other site 1001582005477 active site 1001582005478 primary dimer interface [polypeptide binding]; other site 1001582005479 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001582005480 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001582005481 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001582005482 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1001582005483 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1001582005484 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1001582005485 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1001582005486 YndJ-like protein; Region: YndJ; pfam14158 1001582005487 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001582005488 HAMP domain; Region: HAMP; pfam00672 1001582005489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582005490 dimer interface [polypeptide binding]; other site 1001582005491 phosphorylation site [posttranslational modification] 1001582005492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582005493 ATP binding site [chemical binding]; other site 1001582005494 Mg2+ binding site [ion binding]; other site 1001582005495 G-X-G motif; other site 1001582005496 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001582005497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582005498 active site 1001582005499 phosphorylation site [posttranslational modification] 1001582005500 intermolecular recognition site; other site 1001582005501 dimerization interface [polypeptide binding]; other site 1001582005502 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001582005503 DNA binding site [nucleotide binding] 1001582005504 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1001582005505 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1001582005506 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1001582005507 substrate binding site [chemical binding]; other site 1001582005508 active site 1001582005509 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1001582005510 metal binding site [ion binding]; metal-binding site 1001582005511 ligand binding site [chemical binding]; other site 1001582005512 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1001582005513 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1001582005514 acyl-activating enzyme (AAE) consensus motif; other site 1001582005515 AMP binding site [chemical binding]; other site 1001582005516 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005517 Condensation domain; Region: Condensation; pfam00668 1001582005518 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582005519 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1001582005520 Condensation domain; Region: Condensation; pfam00668 1001582005521 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582005522 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1001582005523 acyl-activating enzyme (AAE) consensus motif; other site 1001582005524 AMP binding site [chemical binding]; other site 1001582005525 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005526 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1001582005527 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1001582005528 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1001582005529 acyl-activating enzyme (AAE) consensus motif; other site 1001582005530 AMP binding site [chemical binding]; other site 1001582005531 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005532 Condensation domain; Region: Condensation; pfam00668 1001582005533 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582005534 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1001582005535 Condensation domain; Region: Condensation; pfam00668 1001582005536 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1001582005537 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1001582005538 acyl-activating enzyme (AAE) consensus motif; other site 1001582005539 AMP binding site [chemical binding]; other site 1001582005540 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005541 Condensation domain; Region: Condensation; pfam00668 1001582005542 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582005543 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1001582005544 Condensation domain; Region: Condensation; pfam00668 1001582005545 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582005546 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1001582005547 acyl-activating enzyme (AAE) consensus motif; other site 1001582005548 AMP binding site [chemical binding]; other site 1001582005549 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005550 Condensation domain; Region: Condensation; pfam00668 1001582005551 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582005552 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1001582005553 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1001582005554 acyl-activating enzyme (AAE) consensus motif; other site 1001582005555 AMP binding site [chemical binding]; other site 1001582005556 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005557 Condensation domain; Region: Condensation; pfam00668 1001582005558 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582005559 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1001582005560 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1001582005561 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 1001582005562 acyl-activating enzyme (AAE) consensus motif; other site 1001582005563 putative AMP binding site [chemical binding]; other site 1001582005564 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005565 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1001582005566 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1001582005567 active site 1001582005568 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005569 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1001582005570 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1001582005571 inhibitor-cofactor binding pocket; inhibition site 1001582005572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582005573 catalytic residue [active] 1001582005574 Condensation domain; Region: Condensation; pfam00668 1001582005575 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582005576 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005577 Condensation domain; Region: Condensation; pfam00668 1001582005578 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582005579 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1001582005580 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1001582005581 acyl-activating enzyme (AAE) consensus motif; other site 1001582005582 AMP binding site [chemical binding]; other site 1001582005583 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005584 Condensation domain; Region: Condensation; pfam00668 1001582005585 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582005586 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1001582005587 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1001582005588 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1001582005589 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1001582005590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001582005591 NAD(P) binding site [chemical binding]; other site 1001582005592 active site 1001582005593 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1001582005594 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1001582005595 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1001582005596 Cytochrome P450; Region: p450; cl12078 1001582005597 biotin synthase; Validated; Region: PRK06256 1001582005598 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001582005599 FeS/SAM binding site; other site 1001582005600 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1001582005601 AAA domain; Region: AAA_26; pfam13500 1001582005602 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1001582005603 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1001582005604 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1001582005605 substrate-cofactor binding pocket; other site 1001582005606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582005607 catalytic residue [active] 1001582005608 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1001582005609 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1001582005610 inhibitor-cofactor binding pocket; inhibition site 1001582005611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582005612 catalytic residue [active] 1001582005613 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 1001582005614 Predicted membrane protein [Function unknown]; Region: COG2246 1001582005615 GtrA-like protein; Region: GtrA; pfam04138 1001582005616 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1001582005617 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1001582005618 active site 1001582005619 tetramer interface; other site 1001582005620 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1001582005621 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1001582005622 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1001582005623 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1001582005624 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1001582005625 enoyl-CoA hydratase; Provisional; Region: PRK07657 1001582005626 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1001582005627 substrate binding site [chemical binding]; other site 1001582005628 oxyanion hole (OAH) forming residues; other site 1001582005629 trimer interface [polypeptide binding]; other site 1001582005630 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1001582005631 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1001582005632 active site 1001582005633 catalytic residues [active] 1001582005634 metal binding site [ion binding]; metal-binding site 1001582005635 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1001582005636 carboxyltransferase (CT) interaction site; other site 1001582005637 biotinylation site [posttranslational modification]; other site 1001582005638 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1001582005639 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1001582005640 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1001582005641 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1001582005642 AMP-binding domain protein; Validated; Region: PRK08315 1001582005643 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1001582005644 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1001582005645 acyl-activating enzyme (AAE) consensus motif; other site 1001582005646 putative AMP binding site [chemical binding]; other site 1001582005647 putative active site [active] 1001582005648 putative CoA binding site [chemical binding]; other site 1001582005649 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1001582005650 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1001582005651 FAD binding site [chemical binding]; other site 1001582005652 homotetramer interface [polypeptide binding]; other site 1001582005653 substrate binding pocket [chemical binding]; other site 1001582005654 catalytic base [active] 1001582005655 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1001582005656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1001582005657 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1001582005658 Condensation domain; Region: Condensation; pfam00668 1001582005659 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582005660 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1001582005661 acyl-activating enzyme (AAE) consensus motif; other site 1001582005662 AMP binding site [chemical binding]; other site 1001582005663 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005664 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1001582005665 Condensation domain; Region: Condensation; pfam00668 1001582005666 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582005667 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1001582005668 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1001582005669 acyl-activating enzyme (AAE) consensus motif; other site 1001582005670 AMP binding site [chemical binding]; other site 1001582005671 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005672 Condensation domain; Region: Condensation; pfam00668 1001582005673 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1001582005674 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1001582005675 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1001582005676 acyl-activating enzyme (AAE) consensus motif; other site 1001582005677 AMP binding site [chemical binding]; other site 1001582005678 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582005679 Condensation domain; Region: Condensation; pfam00668 1001582005680 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1001582005681 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1001582005682 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1001582005683 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1001582005684 active site 1001582005685 catalytic residues [active] 1001582005686 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1001582005687 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1001582005688 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1001582005689 Int/Topo IB signature motif; other site 1001582005690 Helix-turn-helix domain; Region: HTH_17; cl17695 1001582005691 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1001582005692 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1001582005693 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1001582005694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582005695 putative substrate translocation pore; other site 1001582005696 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582005697 dimerization interface [polypeptide binding]; other site 1001582005698 putative DNA binding site [nucleotide binding]; other site 1001582005699 putative Zn2+ binding site [ion binding]; other site 1001582005700 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1001582005701 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001582005702 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1001582005703 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1001582005704 active site 1001582005705 dimer interface [polypeptide binding]; other site 1001582005706 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1001582005707 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1001582005708 active site 1001582005709 FMN binding site [chemical binding]; other site 1001582005710 substrate binding site [chemical binding]; other site 1001582005711 3Fe-4S cluster binding site [ion binding]; other site 1001582005712 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1001582005713 domain interface; other site 1001582005714 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001582005715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001582005716 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1001582005717 putative dimerization interface [polypeptide binding]; other site 1001582005718 gamma-glutamyl kinase; Provisional; Region: PRK13402 1001582005719 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1001582005720 nucleotide binding site [chemical binding]; other site 1001582005721 homotetrameric interface [polypeptide binding]; other site 1001582005722 putative phosphate binding site [ion binding]; other site 1001582005723 putative allosteric binding site; other site 1001582005724 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1001582005725 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1001582005726 Replication terminator protein; Region: RTP; pfam02334 1001582005727 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1001582005728 classical (c) SDRs; Region: SDR_c; cd05233 1001582005729 NAD(P) binding site [chemical binding]; other site 1001582005730 active site 1001582005731 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1001582005732 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1001582005733 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1001582005734 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1001582005735 putative active site [active] 1001582005736 catalytic site [active] 1001582005737 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1001582005738 putative active site [active] 1001582005739 catalytic site [active] 1001582005740 Predicted membrane protein [Function unknown]; Region: COG2323 1001582005741 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1001582005742 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1001582005743 stage V sporulation protein AD; Provisional; Region: PRK12404 1001582005744 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 1001582005745 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1001582005746 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1001582005747 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1001582005748 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1001582005749 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1001582005750 catalytic residues [active] 1001582005751 catalytic nucleophile [active] 1001582005752 Presynaptic Site I dimer interface [polypeptide binding]; other site 1001582005753 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1001582005754 Synaptic Flat tetramer interface [polypeptide binding]; other site 1001582005755 Synaptic Site I dimer interface [polypeptide binding]; other site 1001582005756 DNA binding site [nucleotide binding] 1001582005757 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 1001582005758 DNA-binding interface [nucleotide binding]; DNA binding site 1001582005759 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1001582005760 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1001582005761 polyol permease family; Region: 2A0118; TIGR00897 1001582005762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582005763 putative substrate translocation pore; other site 1001582005764 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1001582005765 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 1001582005766 putative N- and C-terminal domain interface [polypeptide binding]; other site 1001582005767 putative active site [active] 1001582005768 putative MgATP binding site [chemical binding]; other site 1001582005769 catalytic site [active] 1001582005770 metal binding site [ion binding]; metal-binding site 1001582005771 carbohydrate binding site [chemical binding]; other site 1001582005772 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1001582005773 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1001582005774 putative ligand binding site [chemical binding]; other site 1001582005775 putative NAD binding site [chemical binding]; other site 1001582005776 catalytic site [active] 1001582005777 MarR family; Region: MarR_2; pfam12802 1001582005778 MarR family; Region: MarR_2; cl17246 1001582005779 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1001582005780 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1001582005781 dimer interface [polypeptide binding]; other site 1001582005782 putative tRNA-binding site [nucleotide binding]; other site 1001582005783 Cupin domain; Region: Cupin_2; pfam07883 1001582005784 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001582005785 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1001582005786 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001582005787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582005788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582005789 WHG domain; Region: WHG; pfam13305 1001582005790 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1001582005791 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582005792 dimerization interface [polypeptide binding]; other site 1001582005793 putative DNA binding site [nucleotide binding]; other site 1001582005794 putative Zn2+ binding site [ion binding]; other site 1001582005795 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1001582005796 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1001582005797 catalytic residue [active] 1001582005798 Predicted membrane protein [Function unknown]; Region: COG2322 1001582005799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1001582005800 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1001582005801 putative dimer interface [polypeptide binding]; other site 1001582005802 catalytic triad [active] 1001582005803 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582005804 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582005805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1001582005806 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1001582005807 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001582005808 ATP binding site [chemical binding]; other site 1001582005809 putative Mg++ binding site [ion binding]; other site 1001582005810 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001582005811 nucleotide binding region [chemical binding]; other site 1001582005812 ATP-binding site [chemical binding]; other site 1001582005813 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1001582005814 HRDC domain; Region: HRDC; pfam00570 1001582005815 azoreductase; Provisional; Region: PRK13556 1001582005816 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1001582005817 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1001582005818 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1001582005819 putative dimer interface [polypeptide binding]; other site 1001582005820 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1001582005821 pentamer interface [polypeptide binding]; other site 1001582005822 dodecaamer interface [polypeptide binding]; other site 1001582005823 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1001582005824 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1001582005825 NAD(P) binding site [chemical binding]; other site 1001582005826 catalytic residues [active] 1001582005827 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1001582005828 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1001582005829 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1001582005830 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1001582005831 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1001582005832 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1001582005833 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1001582005834 Na2 binding site [ion binding]; other site 1001582005835 putative substrate binding site 1 [chemical binding]; other site 1001582005836 Na binding site 1 [ion binding]; other site 1001582005837 putative substrate binding site 2 [chemical binding]; other site 1001582005838 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1001582005839 Sodium Bile acid symporter family; Region: SBF; pfam01758 1001582005840 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1001582005841 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1001582005842 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1001582005843 E3 interaction surface; other site 1001582005844 lipoyl attachment site [posttranslational modification]; other site 1001582005845 e3 binding domain; Region: E3_binding; pfam02817 1001582005846 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1001582005847 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1001582005848 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1001582005849 TPP-binding site [chemical binding]; other site 1001582005850 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1001582005851 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1001582005852 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1001582005853 metal ion-dependent adhesion site (MIDAS); other site 1001582005854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582005855 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1001582005856 Walker A motif; other site 1001582005857 ATP binding site [chemical binding]; other site 1001582005858 Walker B motif; other site 1001582005859 arginine finger; other site 1001582005860 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1001582005861 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1001582005862 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1001582005863 E-class dimer interface [polypeptide binding]; other site 1001582005864 P-class dimer interface [polypeptide binding]; other site 1001582005865 active site 1001582005866 Cu2+ binding site [ion binding]; other site 1001582005867 Zn2+ binding site [ion binding]; other site 1001582005868 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582005869 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1001582005870 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582005871 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1001582005872 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582005873 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582005874 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1001582005875 NlpC/P60 family; Region: NLPC_P60; pfam00877 1001582005876 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1001582005877 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1001582005878 active site 1001582005879 TDP-binding site; other site 1001582005880 acceptor substrate-binding pocket; other site 1001582005881 homodimer interface [polypeptide binding]; other site 1001582005882 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1001582005883 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1001582005884 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1001582005885 multidrug efflux protein; Reviewed; Region: PRK01766 1001582005886 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1001582005887 cation binding site [ion binding]; other site 1001582005888 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1001582005889 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1001582005890 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1001582005891 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1001582005892 EamA-like transporter family; Region: EamA; pfam00892 1001582005893 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1001582005894 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1001582005895 Predicted transcriptional regulators [Transcription]; Region: COG1733 1001582005896 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582005897 dimerization interface [polypeptide binding]; other site 1001582005898 putative DNA binding site [nucleotide binding]; other site 1001582005899 putative Zn2+ binding site [ion binding]; other site 1001582005900 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1001582005901 dimer interface [polypeptide binding]; other site 1001582005902 FMN binding site [chemical binding]; other site 1001582005903 Predicted esterase [General function prediction only]; Region: COG0400 1001582005904 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1001582005905 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1001582005906 Zn binding site [ion binding]; other site 1001582005907 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1001582005908 Zn binding site [ion binding]; other site 1001582005909 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1001582005910 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1001582005911 Na binding site [ion binding]; other site 1001582005912 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1001582005913 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1001582005914 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1001582005915 beta-galactosidase; Region: BGL; TIGR03356 1001582005916 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1001582005917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582005918 DNA-binding site [nucleotide binding]; DNA binding site 1001582005919 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1001582005920 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1001582005921 C-terminal peptidase (prc); Region: prc; TIGR00225 1001582005922 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1001582005923 protein binding site [polypeptide binding]; other site 1001582005924 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1001582005925 Catalytic dyad [active] 1001582005926 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1001582005927 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1001582005928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582005929 S-adenosylmethionine binding site [chemical binding]; other site 1001582005930 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1001582005931 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1001582005932 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1001582005933 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1001582005934 YodL-like; Region: YodL; pfam14191 1001582005935 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1001582005936 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1001582005937 active site 1001582005938 YozD-like protein; Region: YozD; pfam14162 1001582005939 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1001582005940 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1001582005941 hypothetical protein; Provisional; Region: PRK13672 1001582005942 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1001582005943 Zn binding site [ion binding]; other site 1001582005944 toxin interface [polypeptide binding]; other site 1001582005945 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1001582005946 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001582005947 FeS/SAM binding site; other site 1001582005948 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1001582005949 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1001582005950 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582005951 Coenzyme A binding pocket [chemical binding]; other site 1001582005952 acetylornithine deacetylase; Validated; Region: PRK06915 1001582005953 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1001582005954 metal binding site [ion binding]; metal-binding site 1001582005955 dimer interface [polypeptide binding]; other site 1001582005956 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1001582005957 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1001582005958 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1001582005959 hypothetical protein; Provisional; Region: PRK06917 1001582005960 inhibitor-cofactor binding pocket; inhibition site 1001582005961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582005962 catalytic residue [active] 1001582005963 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1001582005964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582005965 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1001582005966 Coenzyme A binding pocket [chemical binding]; other site 1001582005967 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1001582005968 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1001582005969 active site 1001582005970 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1001582005971 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1001582005972 Phytase; Region: Phytase; cl17685 1001582005973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001582005974 NAD(P) binding site [chemical binding]; other site 1001582005975 active site 1001582005976 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1001582005977 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1001582005978 putative active site [active] 1001582005979 putative substrate binding site [chemical binding]; other site 1001582005980 putative FMN binding site [chemical binding]; other site 1001582005981 putative catalytic residues [active] 1001582005982 Regulatory protein YrvL; Region: YrvL; pfam14184 1001582005983 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1001582005984 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1001582005985 catalytic residues [active] 1001582005986 catalytic nucleophile [active] 1001582005987 Recombinase; Region: Recombinase; pfam07508 1001582005988 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1001582005989 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1001582005990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001582005991 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1001582005992 SelR domain; Region: SelR; pfam01641 1001582005993 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1001582005994 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582005995 MarR family; Region: MarR; pfam01047 1001582005996 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1001582005997 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1001582005998 active site 1001582005999 catalytic triad [active] 1001582006000 oxyanion hole [active] 1001582006001 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1001582006002 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1001582006003 Cu(I) binding site [ion binding]; other site 1001582006004 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1001582006005 threonine dehydratase; Validated; Region: PRK08639 1001582006006 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1001582006007 tetramer interface [polypeptide binding]; other site 1001582006008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582006009 catalytic residue [active] 1001582006010 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1001582006011 putative Ile/Val binding site [chemical binding]; other site 1001582006012 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1001582006013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582006014 Walker A motif; other site 1001582006015 ATP binding site [chemical binding]; other site 1001582006016 Walker B motif; other site 1001582006017 arginine finger; other site 1001582006018 Haemolysin-III related; Region: HlyIII; cl03831 1001582006019 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1001582006020 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1001582006021 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1001582006022 putative acyl-acceptor binding pocket; other site 1001582006023 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1001582006024 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1001582006025 folate binding site [chemical binding]; other site 1001582006026 NADP+ binding site [chemical binding]; other site 1001582006027 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1001582006028 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1001582006029 dimerization interface [polypeptide binding]; other site 1001582006030 active site 1001582006031 YpjP-like protein; Region: YpjP; pfam14005 1001582006032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582006033 S-adenosylmethionine binding site [chemical binding]; other site 1001582006034 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1001582006035 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1001582006036 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1001582006037 Virulence factor; Region: Virulence_fact; pfam13769 1001582006038 HEAT repeats; Region: HEAT_2; pfam13646 1001582006039 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1001582006040 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1001582006041 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001582006042 Zn2+ binding site [ion binding]; other site 1001582006043 Mg2+ binding site [ion binding]; other site 1001582006044 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1001582006045 catalytic residues [active] 1001582006046 dimer interface [polypeptide binding]; other site 1001582006047 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1001582006048 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1001582006049 proposed active site lysine [active] 1001582006050 conserved cys residue [active] 1001582006051 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1001582006052 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1001582006053 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1001582006054 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1001582006055 DNA-binding site [nucleotide binding]; DNA binding site 1001582006056 RNA-binding motif; other site 1001582006057 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1001582006058 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1001582006059 hypothetical protein; Validated; Region: PRK07708 1001582006060 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1001582006061 RNA/DNA hybrid binding site [nucleotide binding]; other site 1001582006062 active site 1001582006063 conserved hypothetical integral membrane protein; Region: TIGR00697 1001582006064 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1001582006065 RNA/DNA hybrid binding site [nucleotide binding]; other site 1001582006066 active site 1001582006067 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1001582006068 5'-3' exonuclease; Region: 53EXOc; smart00475 1001582006069 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1001582006070 active site 1001582006071 metal binding site 1 [ion binding]; metal-binding site 1001582006072 putative 5' ssDNA interaction site; other site 1001582006073 metal binding site 3; metal-binding site 1001582006074 metal binding site 2 [ion binding]; metal-binding site 1001582006075 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1001582006076 putative DNA binding site [nucleotide binding]; other site 1001582006077 putative metal binding site [ion binding]; other site 1001582006078 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1001582006079 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1001582006080 Dynamin family; Region: Dynamin_N; pfam00350 1001582006081 G1 box; other site 1001582006082 GTP/Mg2+ binding site [chemical binding]; other site 1001582006083 G2 box; other site 1001582006084 Switch I region; other site 1001582006085 G3 box; other site 1001582006086 Switch II region; other site 1001582006087 G4 box; other site 1001582006088 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1001582006089 G1 box; other site 1001582006090 GTP/Mg2+ binding site [chemical binding]; other site 1001582006091 Dynamin family; Region: Dynamin_N; pfam00350 1001582006092 G2 box; other site 1001582006093 Switch I region; other site 1001582006094 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1001582006095 G3 box; other site 1001582006096 Switch II region; other site 1001582006097 GTP/Mg2+ binding site [chemical binding]; other site 1001582006098 G4 box; other site 1001582006099 G5 box; other site 1001582006100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1001582006101 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1001582006102 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1001582006103 malonyl-CoA binding site [chemical binding]; other site 1001582006104 dimer interface [polypeptide binding]; other site 1001582006105 active site 1001582006106 product binding site; other site 1001582006107 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1001582006108 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1001582006109 DNA binding site [nucleotide binding] 1001582006110 active site 1001582006111 xanthine permease; Region: pbuX; TIGR03173 1001582006112 Penicillin-binding protein-related factor A, putative recombinase [General function prediction only]; Region: PrfA; COG3331 1001582006113 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1001582006114 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1001582006115 active site 1001582006116 metal binding site [ion binding]; metal-binding site 1001582006117 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1001582006118 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1001582006119 folate binding site [chemical binding]; other site 1001582006120 NADP+ binding site [chemical binding]; other site 1001582006121 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1001582006122 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1001582006123 dimerization interface [polypeptide binding]; other site 1001582006124 active site 1001582006125 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1001582006126 trimer interface [polypeptide binding]; other site 1001582006127 active site 1001582006128 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001582006129 catalytic residues [active] 1001582006130 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1001582006131 dimer interface [polypeptide binding]; other site 1001582006132 putative radical transfer pathway; other site 1001582006133 diiron center [ion binding]; other site 1001582006134 tyrosyl radical; other site 1001582006135 group I intron endonuclease; Region: grpIintron_endo; TIGR01453 1001582006136 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 1001582006137 GIY-YIG motif/motif A; other site 1001582006138 putative active site [active] 1001582006139 catalytic site [active] 1001582006140 putative metal binding site [ion binding]; other site 1001582006141 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cd00283 1001582006142 DNA binding site [nucleotide binding] 1001582006143 NUMOD4 motif; Region: NUMOD4; pfam07463 1001582006144 HNH endonuclease; Region: HNH_3; pfam13392 1001582006145 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1001582006146 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1001582006147 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 1001582006148 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1001582006149 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 1001582006150 cofactor binding site; other site 1001582006151 DNA binding site [nucleotide binding] 1001582006152 substrate interaction site [chemical binding]; other site 1001582006153 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1001582006154 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1001582006155 DNA methylase; Region: N6_N4_Mtase; pfam01555 1001582006156 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 1001582006157 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1001582006158 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1001582006159 active site 1001582006160 ribulose-bisphosphate carboxylase small chain; Region: PLN02289 1001582006161 YorP protein; Region: YorP; pfam09629 1001582006162 3D domain; Region: 3D; cl01439 1001582006163 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1001582006164 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1001582006165 active site 1001582006166 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1001582006167 DHH family; Region: DHH; pfam01368 1001582006168 hypothetical protein; Provisional; Region: PRK08624 1001582006169 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 1001582006170 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1001582006171 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1001582006172 ATP binding site [chemical binding]; other site 1001582006173 Walker B motif; other site 1001582006174 AAA domain; Region: AAA_24; pfam13479 1001582006175 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1001582006176 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1001582006177 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1001582006178 YopX protein; Region: YopX; pfam09643 1001582006179 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1001582006180 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 1001582006181 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1001582006182 active site 1001582006183 DNA binding site [nucleotide binding] 1001582006184 YoqO-like protein; Region: YoqO; pfam14037 1001582006185 Protein of unknown function DUF262; Region: DUF262; pfam03235 1001582006186 YopX protein; Region: YopX; pfam09643 1001582006187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582006188 salt bridge; other site 1001582006189 non-specific DNA binding site [nucleotide binding]; other site 1001582006190 sequence-specific DNA binding site [nucleotide binding]; other site 1001582006191 DNA-sulfur modification-associated; Region: DndB; cl17621 1001582006192 DGQHR domain; Region: DGQHR; TIGR03187 1001582006193 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1001582006194 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1001582006195 active site 1001582006196 catalytic residues [active] 1001582006197 DNA binding site [nucleotide binding] 1001582006198 Int/Topo IB signature motif; other site 1001582006199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582006200 non-specific DNA binding site [nucleotide binding]; other site 1001582006201 salt bridge; other site 1001582006202 sequence-specific DNA binding site [nucleotide binding]; other site 1001582006203 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1001582006204 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1001582006205 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1001582006206 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1001582006207 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1001582006208 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1001582006209 Part of AAA domain; Region: AAA_19; pfam13245 1001582006210 Family description; Region: UvrD_C_2; pfam13538 1001582006211 ORF6C domain; Region: ORF6C; pfam10552 1001582006212 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 1001582006213 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1001582006214 nucleotide binding site [chemical binding]; other site 1001582006215 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1001582006216 IHF dimer interface [polypeptide binding]; other site 1001582006217 IHF - DNA interface [nucleotide binding]; other site 1001582006218 YonK protein; Region: YonK; pfam09642 1001582006219 Terminase-like family; Region: Terminase_6; pfam03237 1001582006220 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1001582006221 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1001582006222 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1001582006223 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1001582006224 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1001582006225 active site 1001582006226 catalytic site [active] 1001582006227 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1001582006228 active site 1001582006229 catalytic residues [active] 1001582006230 DNA binding site [nucleotide binding] 1001582006231 Int/Topo IB signature motif; other site 1001582006232 Phage-related protein [Function unknown]; Region: COG4722 1001582006233 Phage tail protein; Region: Sipho_tail; cl17486 1001582006234 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1001582006235 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1001582006236 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1001582006237 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1001582006238 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1001582006239 amidase catalytic site [active] 1001582006240 Zn binding residues [ion binding]; other site 1001582006241 substrate binding site [chemical binding]; other site 1001582006242 Bacterial SH3 domain; Region: SH3_3; pfam08239 1001582006243 Bacteriophage holin; Region: Phage_holin_1; pfam04531 1001582006244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582006245 TPR motif; other site 1001582006246 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582006247 binding surface 1001582006248 Y-family of DNA polymerases; Region: PolY; cl12025 1001582006249 DNA binding site [nucleotide binding] 1001582006250 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1001582006251 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1001582006252 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1001582006253 putative active site [active] 1001582006254 putative NTP binding site [chemical binding]; other site 1001582006255 putative nucleic acid binding site [nucleotide binding]; other site 1001582006256 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1001582006257 Type II intron maturase; Region: Intron_maturas2; pfam01348 1001582006258 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1001582006259 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1001582006260 active site 1001582006261 YolD-like protein; Region: YolD; pfam08863 1001582006262 sporulation protein YunB; Region: spo_yunB; TIGR02832 1001582006263 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1001582006264 LXG domain of WXG superfamily; Region: LXG; pfam04740 1001582006265 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 1001582006266 Staphylococcal nuclease homologues; Region: SNc; smart00318 1001582006267 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1001582006268 Catalytic site; other site 1001582006269 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1001582006270 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1001582006271 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1001582006272 catalytic residues [active] 1001582006273 catalytic nucleophile [active] 1001582006274 Recombinase; Region: Recombinase; pfam07508 1001582006275 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1001582006276 xanthine permease; Region: pbuX; TIGR03173 1001582006277 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001582006278 active site 1001582006279 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1001582006280 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1001582006281 active site 1001582006282 Zn binding site [ion binding]; other site 1001582006283 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1001582006284 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1001582006285 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1001582006286 YpzG-like protein; Region: YpzG; pfam14139 1001582006287 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1001582006288 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1001582006289 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1001582006290 cell division protein GpsB; Provisional; Region: PRK14127 1001582006291 DivIVA domain; Region: DivI1A_domain; TIGR03544 1001582006292 hypothetical protein; Provisional; Region: PRK13660 1001582006293 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1001582006294 RNase_H superfamily; Region: RNase_H_2; pfam13482 1001582006295 active site 1001582006296 substrate binding site [chemical binding]; other site 1001582006297 catalytic site [active] 1001582006298 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1001582006299 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001582006300 ATP binding site [chemical binding]; other site 1001582006301 putative Mg++ binding site [ion binding]; other site 1001582006302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001582006303 nucleotide binding region [chemical binding]; other site 1001582006304 ATP-binding site [chemical binding]; other site 1001582006305 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1001582006306 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1001582006307 HPr interaction site; other site 1001582006308 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1001582006309 active site 1001582006310 phosphorylation site [posttranslational modification] 1001582006311 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1001582006312 YppG-like protein; Region: YppG; pfam14179 1001582006313 YppF-like protein; Region: YppF; pfam14178 1001582006314 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1001582006315 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1001582006316 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1001582006317 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1001582006318 Transglycosylase; Region: Transgly; pfam00912 1001582006319 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1001582006320 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1001582006321 Interdomain contacts; other site 1001582006322 Cytokine receptor motif; other site 1001582006323 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1001582006324 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1001582006325 minor groove reading motif; other site 1001582006326 helix-hairpin-helix signature motif; other site 1001582006327 substrate binding pocket [chemical binding]; other site 1001582006328 active site 1001582006329 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1001582006330 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1001582006331 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1001582006332 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1001582006333 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1001582006334 putative dimer interface [polypeptide binding]; other site 1001582006335 putative anticodon binding site; other site 1001582006336 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1001582006337 homodimer interface [polypeptide binding]; other site 1001582006338 motif 1; other site 1001582006339 motif 2; other site 1001582006340 active site 1001582006341 motif 3; other site 1001582006342 aspartate aminotransferase; Provisional; Region: PRK05764 1001582006343 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001582006344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582006345 homodimer interface [polypeptide binding]; other site 1001582006346 catalytic residue [active] 1001582006347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1001582006348 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1001582006349 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1001582006350 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1001582006351 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1001582006352 active site 1001582006353 catalytic site [active] 1001582006354 substrate binding site [chemical binding]; other site 1001582006355 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1001582006356 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1001582006357 tetramerization interface [polypeptide binding]; other site 1001582006358 active site 1001582006359 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1001582006360 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1001582006361 active site 1001582006362 ATP-binding site [chemical binding]; other site 1001582006363 pantoate-binding site; other site 1001582006364 HXXH motif; other site 1001582006365 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1001582006366 oligomerization interface [polypeptide binding]; other site 1001582006367 active site 1001582006368 metal binding site [ion binding]; metal-binding site 1001582006369 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1001582006370 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1001582006371 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1001582006372 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1001582006373 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1001582006374 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1001582006375 active site 1001582006376 NTP binding site [chemical binding]; other site 1001582006377 metal binding triad [ion binding]; metal-binding site 1001582006378 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1001582006379 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1001582006380 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1001582006381 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1001582006382 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1001582006383 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1001582006384 active site 1001582006385 dimer interfaces [polypeptide binding]; other site 1001582006386 catalytic residues [active] 1001582006387 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1001582006388 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1001582006389 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1001582006390 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1001582006391 homodimer interface [polypeptide binding]; other site 1001582006392 metal binding site [ion binding]; metal-binding site 1001582006393 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1001582006394 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001582006395 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001582006396 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1001582006397 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1001582006398 Cupin; Region: Cupin_1; smart00835 1001582006399 Cupin; Region: Cupin_1; smart00835 1001582006400 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 1001582006401 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 1001582006402 Qo binding site; other site 1001582006403 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1001582006404 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1001582006405 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1001582006406 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1001582006407 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1001582006408 interchain domain interface [polypeptide binding]; other site 1001582006409 intrachain domain interface; other site 1001582006410 heme bH binding site [chemical binding]; other site 1001582006411 Qi binding site; other site 1001582006412 heme bL binding site [chemical binding]; other site 1001582006413 Qo binding site; other site 1001582006414 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1001582006415 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1001582006416 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1001582006417 iron-sulfur cluster [ion binding]; other site 1001582006418 [2Fe-2S] cluster binding site [ion binding]; other site 1001582006419 hypothetical protein; Provisional; Region: PRK03636 1001582006420 UPF0302 domain; Region: UPF0302; pfam08864 1001582006421 IDEAL domain; Region: IDEAL; pfam08858 1001582006422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1001582006423 TPR motif; other site 1001582006424 binding surface 1001582006425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582006426 binding surface 1001582006427 TPR motif; other site 1001582006428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582006429 TPR motif; other site 1001582006430 binding surface 1001582006431 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1001582006432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582006433 binding surface 1001582006434 TPR motif; other site 1001582006435 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1001582006436 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1001582006437 hinge; other site 1001582006438 active site 1001582006439 prephenate dehydrogenase; Validated; Region: PRK06545 1001582006440 prephenate dehydrogenase; Validated; Region: PRK08507 1001582006441 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1001582006442 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1001582006443 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001582006444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582006445 homodimer interface [polypeptide binding]; other site 1001582006446 catalytic residue [active] 1001582006447 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1001582006448 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1001582006449 substrate binding site [chemical binding]; other site 1001582006450 active site 1001582006451 catalytic residues [active] 1001582006452 heterodimer interface [polypeptide binding]; other site 1001582006453 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1001582006454 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1001582006455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582006456 catalytic residue [active] 1001582006457 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1001582006458 active site 1001582006459 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1001582006460 active site 1001582006461 ribulose/triose binding site [chemical binding]; other site 1001582006462 phosphate binding site [ion binding]; other site 1001582006463 substrate (anthranilate) binding pocket [chemical binding]; other site 1001582006464 product (indole) binding pocket [chemical binding]; other site 1001582006465 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1001582006466 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1001582006467 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1001582006468 anthranilate synthase component I; Provisional; Region: PRK13569 1001582006469 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1001582006470 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1001582006471 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1001582006472 homotrimer interaction site [polypeptide binding]; other site 1001582006473 active site 1001582006474 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1001582006475 active site 1001582006476 dimer interface [polypeptide binding]; other site 1001582006477 metal binding site [ion binding]; metal-binding site 1001582006478 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1001582006479 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1001582006480 Tetramer interface [polypeptide binding]; other site 1001582006481 active site 1001582006482 FMN-binding site [chemical binding]; other site 1001582006483 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1001582006484 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1001582006485 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1001582006486 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1001582006487 active site 1001582006488 multimer interface [polypeptide binding]; other site 1001582006489 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1001582006490 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1001582006491 substrate binding pocket [chemical binding]; other site 1001582006492 chain length determination region; other site 1001582006493 substrate-Mg2+ binding site; other site 1001582006494 catalytic residues [active] 1001582006495 aspartate-rich region 1; other site 1001582006496 active site lid residues [active] 1001582006497 aspartate-rich region 2; other site 1001582006498 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1001582006499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582006500 S-adenosylmethionine binding site [chemical binding]; other site 1001582006501 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1001582006502 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 1001582006503 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1001582006504 homodecamer interface [polypeptide binding]; other site 1001582006505 GTP cyclohydrolase I; Provisional; Region: PLN03044 1001582006506 active site 1001582006507 putative catalytic site residues [active] 1001582006508 zinc binding site [ion binding]; other site 1001582006509 GTP-CH-I/GFRP interaction surface; other site 1001582006510 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1001582006511 IHF dimer interface [polypeptide binding]; other site 1001582006512 IHF - DNA interface [nucleotide binding]; other site 1001582006513 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1001582006514 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1001582006515 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1001582006516 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1001582006517 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1001582006518 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1001582006519 GTP-binding protein Der; Reviewed; Region: PRK00093 1001582006520 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1001582006521 G1 box; other site 1001582006522 GTP/Mg2+ binding site [chemical binding]; other site 1001582006523 Switch I region; other site 1001582006524 G2 box; other site 1001582006525 Switch II region; other site 1001582006526 G3 box; other site 1001582006527 G4 box; other site 1001582006528 G5 box; other site 1001582006529 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1001582006530 G1 box; other site 1001582006531 GTP/Mg2+ binding site [chemical binding]; other site 1001582006532 Switch I region; other site 1001582006533 G2 box; other site 1001582006534 G3 box; other site 1001582006535 Switch II region; other site 1001582006536 G4 box; other site 1001582006537 G5 box; other site 1001582006538 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1001582006539 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1001582006540 homotetramer interface [polypeptide binding]; other site 1001582006541 FMN binding site [chemical binding]; other site 1001582006542 homodimer contacts [polypeptide binding]; other site 1001582006543 putative active site [active] 1001582006544 putative substrate binding site [chemical binding]; other site 1001582006545 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1001582006546 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1001582006547 RNA binding site [nucleotide binding]; other site 1001582006548 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1001582006549 RNA binding site [nucleotide binding]; other site 1001582006550 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1001582006551 RNA binding site [nucleotide binding]; other site 1001582006552 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1001582006553 RNA binding site [nucleotide binding]; other site 1001582006554 cytidylate kinase; Provisional; Region: cmk; PRK00023 1001582006555 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1001582006556 CMP-binding site; other site 1001582006557 The sites determining sugar specificity; other site 1001582006558 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1001582006559 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1001582006560 PilZ domain; Region: PilZ; pfam07238 1001582006561 germination protein YpeB; Region: spore_YpeB; TIGR02889 1001582006562 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1001582006563 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1001582006564 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1001582006565 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1001582006566 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1001582006567 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1001582006568 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1001582006569 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1001582006570 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1001582006571 NAD(P) binding site [chemical binding]; other site 1001582006572 adaptor protein; Provisional; Region: PRK02899 1001582006573 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1001582006574 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1001582006575 putative active site [active] 1001582006576 putative metal binding site [ion binding]; other site 1001582006577 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1001582006578 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582006579 CAAX protease self-immunity; Region: Abi; pfam02517 1001582006580 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1001582006581 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001582006582 ATP binding site [chemical binding]; other site 1001582006583 putative Mg++ binding site [ion binding]; other site 1001582006584 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001582006585 nucleotide binding region [chemical binding]; other site 1001582006586 ATP-binding site [chemical binding]; other site 1001582006587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1001582006588 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1001582006589 Predicted membrane protein [Function unknown]; Region: COG3601 1001582006590 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1001582006591 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1001582006592 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1001582006593 ligand binding site [chemical binding]; other site 1001582006594 NAD binding site [chemical binding]; other site 1001582006595 dimerization interface [polypeptide binding]; other site 1001582006596 catalytic site [active] 1001582006597 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1001582006598 putative L-serine binding site [chemical binding]; other site 1001582006599 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1001582006600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001582006601 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582006602 DNA binding residues [nucleotide binding] 1001582006603 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1001582006604 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1001582006605 dimerization interface [polypeptide binding]; other site 1001582006606 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1001582006607 putative active site [active] 1001582006608 heme pocket [chemical binding]; other site 1001582006609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582006610 dimer interface [polypeptide binding]; other site 1001582006611 phosphorylation site [posttranslational modification] 1001582006612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582006613 ATP binding site [chemical binding]; other site 1001582006614 Mg2+ binding site [ion binding]; other site 1001582006615 G-X-G motif; other site 1001582006616 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001582006617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582006618 active site 1001582006619 phosphorylation site [posttranslational modification] 1001582006620 intermolecular recognition site; other site 1001582006621 dimerization interface [polypeptide binding]; other site 1001582006622 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001582006623 DNA binding site [nucleotide binding] 1001582006624 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1001582006625 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1001582006626 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1001582006627 ResB-like family; Region: ResB; pfam05140 1001582006628 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1001582006629 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1001582006630 catalytic residues [active] 1001582006631 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1001582006632 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001582006633 RNA binding surface [nucleotide binding]; other site 1001582006634 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1001582006635 active site 1001582006636 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1001582006637 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1001582006638 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1001582006639 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1001582006640 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1001582006641 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1001582006642 segregation and condensation protein B; Region: TIGR00281 1001582006643 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1001582006644 Domain of unknown function (DUF309); Region: DUF309; cl00667 1001582006645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582006646 Coenzyme A binding pocket [chemical binding]; other site 1001582006647 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1001582006648 homopentamer interface [polypeptide binding]; other site 1001582006649 active site 1001582006650 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1001582006651 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1001582006652 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1001582006653 dimerization interface [polypeptide binding]; other site 1001582006654 active site 1001582006655 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1001582006656 Lumazine binding domain; Region: Lum_binding; pfam00677 1001582006657 Lumazine binding domain; Region: Lum_binding; pfam00677 1001582006658 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1001582006659 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1001582006660 catalytic motif [active] 1001582006661 Zn binding site [ion binding]; other site 1001582006662 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1001582006663 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1001582006664 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1001582006665 Catalytic site [active] 1001582006666 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1001582006667 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1001582006668 active site 1001582006669 Predicted secreted protein [Function unknown]; Region: COG4086 1001582006670 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1001582006671 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1001582006672 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1001582006673 active site 1001582006674 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1001582006675 substrate binding site [chemical binding]; other site 1001582006676 catalytic residues [active] 1001582006677 dimer interface [polypeptide binding]; other site 1001582006678 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1001582006679 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1001582006680 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1001582006681 stage V sporulation protein AD; Validated; Region: PRK08304 1001582006682 stage V sporulation protein AD; Provisional; Region: PRK12404 1001582006683 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1001582006684 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1001582006685 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1001582006686 sporulation sigma factor SigF; Validated; Region: PRK05572 1001582006687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001582006688 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1001582006689 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582006690 DNA binding residues [nucleotide binding] 1001582006691 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1001582006692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582006693 ATP binding site [chemical binding]; other site 1001582006694 Mg2+ binding site [ion binding]; other site 1001582006695 G-X-G motif; other site 1001582006696 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1001582006697 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1001582006698 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1001582006699 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1001582006700 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1001582006701 phosphopentomutase; Provisional; Region: PRK05362 1001582006702 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1001582006703 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1001582006704 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1001582006705 active site 1001582006706 Int/Topo IB signature motif; other site 1001582006707 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1001582006708 ferric uptake regulator; Provisional; Region: fur; PRK09462 1001582006709 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1001582006710 metal binding site 2 [ion binding]; metal-binding site 1001582006711 putative DNA binding helix; other site 1001582006712 metal binding site 1 [ion binding]; metal-binding site 1001582006713 dimer interface [polypeptide binding]; other site 1001582006714 structural Zn2+ binding site [ion binding]; other site 1001582006715 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1001582006716 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1001582006717 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1001582006718 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1001582006719 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 1001582006720 NAD(P) binding pocket [chemical binding]; other site 1001582006721 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1001582006722 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1001582006723 Aspartase; Region: Aspartase; cd01357 1001582006724 active sites [active] 1001582006725 tetramer interface [polypeptide binding]; other site 1001582006726 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1001582006727 active site 1001582006728 homodimer interface [polypeptide binding]; other site 1001582006729 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001582006730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582006731 non-specific DNA binding site [nucleotide binding]; other site 1001582006732 salt bridge; other site 1001582006733 sequence-specific DNA binding site [nucleotide binding]; other site 1001582006734 TIGR00375 family protein; Region: TIGR00375 1001582006735 PHP-associated; Region: PHP_C; pfam13263 1001582006736 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1001582006737 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1001582006738 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1001582006739 dimer interface [polypeptide binding]; other site 1001582006740 ADP-ribose binding site [chemical binding]; other site 1001582006741 active site 1001582006742 nudix motif; other site 1001582006743 metal binding site [ion binding]; metal-binding site 1001582006744 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1001582006745 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001582006746 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001582006747 active site 1001582006748 catalytic tetrad [active] 1001582006749 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1001582006750 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1001582006751 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1001582006752 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1001582006753 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1001582006754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1001582006755 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1001582006756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582006757 Coenzyme A binding pocket [chemical binding]; other site 1001582006758 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1001582006759 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1001582006760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582006761 Coenzyme A binding pocket [chemical binding]; other site 1001582006762 DNA polymerase IV; Reviewed; Region: PRK03103 1001582006763 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1001582006764 active site 1001582006765 DNA binding site [nucleotide binding] 1001582006766 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1001582006767 YolD-like protein; Region: YolD; pfam08863 1001582006768 YqzH-like protein; Region: YqzH; pfam14164 1001582006769 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1001582006770 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1001582006771 pantothenate kinase; Provisional; Region: PRK05439 1001582006772 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1001582006773 ATP-binding site [chemical binding]; other site 1001582006774 CoA-binding site [chemical binding]; other site 1001582006775 Mg2+-binding site [ion binding]; other site 1001582006776 D-serine dehydratase; Provisional; Region: PRK02991 1001582006777 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1001582006778 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001582006779 catalytic residue [active] 1001582006780 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1001582006781 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001582006782 NAD(P) binding site [chemical binding]; other site 1001582006783 active site 1001582006784 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1001582006785 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1001582006786 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1001582006787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001582006788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001582006789 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1001582006790 dimerization interface [polypeptide binding]; other site 1001582006791 GlpM protein; Region: GlpM; cl01212 1001582006792 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1001582006793 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1001582006794 active site 1001582006795 FMN binding site [chemical binding]; other site 1001582006796 substrate binding site [chemical binding]; other site 1001582006797 homotetramer interface [polypeptide binding]; other site 1001582006798 catalytic residue [active] 1001582006799 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1001582006800 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1001582006801 ribonuclease Z; Region: RNase_Z; TIGR02651 1001582006802 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1001582006803 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1001582006804 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1001582006805 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1001582006806 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1001582006807 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1001582006808 DNA polymerase IV; Validated; Region: PRK01810 1001582006809 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1001582006810 active site 1001582006811 DNA binding site [nucleotide binding] 1001582006812 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1001582006813 OxaA-like protein precursor; Validated; Region: PRK01622 1001582006814 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1001582006815 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1001582006816 peptidase T-like protein; Region: PepT-like; TIGR01883 1001582006817 metal binding site [ion binding]; metal-binding site 1001582006818 putative dimer interface [polypeptide binding]; other site 1001582006819 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1001582006820 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1001582006821 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1001582006822 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1001582006823 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1001582006824 dimer interface [polypeptide binding]; other site 1001582006825 substrate binding site [chemical binding]; other site 1001582006826 metal binding site [ion binding]; metal-binding site 1001582006827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1001582006828 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1001582006829 Predicted membrane protein [Function unknown]; Region: COG4129 1001582006830 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1001582006831 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1001582006832 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1001582006833 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1001582006834 Walker A/P-loop; other site 1001582006835 ATP binding site [chemical binding]; other site 1001582006836 Q-loop/lid; other site 1001582006837 ABC transporter signature motif; other site 1001582006838 Walker B; other site 1001582006839 D-loop; other site 1001582006840 H-loop/switch region; other site 1001582006841 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1001582006842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582006843 dimer interface [polypeptide binding]; other site 1001582006844 conserved gate region; other site 1001582006845 putative PBP binding loops; other site 1001582006846 ABC-ATPase subunit interface; other site 1001582006847 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1001582006848 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1001582006849 substrate binding pocket [chemical binding]; other site 1001582006850 membrane-bound complex binding site; other site 1001582006851 hinge residues; other site 1001582006852 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1001582006853 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1001582006854 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1001582006855 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1001582006856 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1001582006857 E3 interaction surface; other site 1001582006858 lipoyl attachment site [posttranslational modification]; other site 1001582006859 e3 binding domain; Region: E3_binding; pfam02817 1001582006860 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1001582006861 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1001582006862 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1001582006863 alpha subunit interface [polypeptide binding]; other site 1001582006864 TPP binding site [chemical binding]; other site 1001582006865 heterodimer interface [polypeptide binding]; other site 1001582006866 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1001582006867 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1001582006868 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1001582006869 tetramer interface [polypeptide binding]; other site 1001582006870 TPP-binding site [chemical binding]; other site 1001582006871 heterodimer interface [polypeptide binding]; other site 1001582006872 phosphorylation loop region [posttranslational modification] 1001582006873 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1001582006874 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1001582006875 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001582006876 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1001582006877 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1001582006878 nucleotide binding site [chemical binding]; other site 1001582006879 Acetokinase family; Region: Acetate_kinase; cl17229 1001582006880 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1001582006881 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1001582006882 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1001582006883 NAD binding site [chemical binding]; other site 1001582006884 Phe binding site; other site 1001582006885 phosphate butyryltransferase; Validated; Region: PRK07742 1001582006886 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1001582006887 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1001582006888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1001582006889 putative active site [active] 1001582006890 heme pocket [chemical binding]; other site 1001582006891 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1001582006892 putative active site [active] 1001582006893 heme pocket [chemical binding]; other site 1001582006894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582006895 Walker A motif; other site 1001582006896 ATP binding site [chemical binding]; other site 1001582006897 Walker B motif; other site 1001582006898 arginine finger; other site 1001582006899 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1001582006900 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1001582006901 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1001582006902 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1001582006903 tetramer interface [polypeptide binding]; other site 1001582006904 active site 1001582006905 Mg2+/Mn2+ binding site [ion binding]; other site 1001582006906 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1001582006907 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1001582006908 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1001582006909 dimer interface [polypeptide binding]; other site 1001582006910 Citrate synthase; Region: Citrate_synt; pfam00285 1001582006911 active site 1001582006912 coenzyme A binding site [chemical binding]; other site 1001582006913 citrylCoA binding site [chemical binding]; other site 1001582006914 oxalacetate/citrate binding site [chemical binding]; other site 1001582006915 catalytic triad [active] 1001582006916 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1001582006917 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1001582006918 FAD binding site [chemical binding]; other site 1001582006919 homotetramer interface [polypeptide binding]; other site 1001582006920 substrate binding pocket [chemical binding]; other site 1001582006921 catalytic base [active] 1001582006922 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1001582006923 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1001582006924 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1001582006925 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1001582006926 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1001582006927 dimer interface [polypeptide binding]; other site 1001582006928 active site 1001582006929 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1001582006930 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1001582006931 active site 1001582006932 catalytic site [active] 1001582006933 metal binding site [ion binding]; metal-binding site 1001582006934 dimer interface [polypeptide binding]; other site 1001582006935 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1001582006936 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1001582006937 active site 1001582006938 metal binding site [ion binding]; metal-binding site 1001582006939 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1001582006940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582006941 sequence-specific DNA binding site [nucleotide binding]; other site 1001582006942 salt bridge; other site 1001582006943 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1001582006944 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1001582006945 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1001582006946 putative active site [active] 1001582006947 putative FMN binding site [chemical binding]; other site 1001582006948 putative substrate binding site [chemical binding]; other site 1001582006949 putative catalytic residue [active] 1001582006950 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1001582006951 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1001582006952 alanine racemase; Region: alr; TIGR00492 1001582006953 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1001582006954 active site 1001582006955 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1001582006956 dimer interface [polypeptide binding]; other site 1001582006957 substrate binding site [chemical binding]; other site 1001582006958 catalytic residues [active] 1001582006959 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1001582006960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582006961 active site 1001582006962 phosphorylation site [posttranslational modification] 1001582006963 intermolecular recognition site; other site 1001582006964 dimerization interface [polypeptide binding]; other site 1001582006965 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1001582006966 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1001582006967 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1001582006968 protein binding site [polypeptide binding]; other site 1001582006969 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1001582006970 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1001582006971 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1001582006972 Walker A/P-loop; other site 1001582006973 ATP binding site [chemical binding]; other site 1001582006974 Q-loop/lid; other site 1001582006975 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1001582006976 ABC transporter signature motif; other site 1001582006977 Walker B; other site 1001582006978 D-loop; other site 1001582006979 H-loop/switch region; other site 1001582006980 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1001582006981 arginine repressor; Provisional; Region: PRK04280 1001582006982 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1001582006983 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1001582006984 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001582006985 RNA binding surface [nucleotide binding]; other site 1001582006986 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1001582006987 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1001582006988 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1001582006989 TPP-binding site; other site 1001582006990 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1001582006991 PYR/PP interface [polypeptide binding]; other site 1001582006992 dimer interface [polypeptide binding]; other site 1001582006993 TPP binding site [chemical binding]; other site 1001582006994 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1001582006995 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1001582006996 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1001582006997 substrate binding pocket [chemical binding]; other site 1001582006998 chain length determination region; other site 1001582006999 substrate-Mg2+ binding site; other site 1001582007000 catalytic residues [active] 1001582007001 aspartate-rich region 1; other site 1001582007002 active site lid residues [active] 1001582007003 aspartate-rich region 2; other site 1001582007004 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1001582007005 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1001582007006 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1001582007007 generic binding surface II; other site 1001582007008 generic binding surface I; other site 1001582007009 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1001582007010 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1001582007011 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1001582007012 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1001582007013 homodimer interface [polypeptide binding]; other site 1001582007014 NADP binding site [chemical binding]; other site 1001582007015 substrate binding site [chemical binding]; other site 1001582007016 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1001582007017 putative RNA binding site [nucleotide binding]; other site 1001582007018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1001582007019 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1001582007020 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1001582007021 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1001582007022 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1001582007023 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1001582007024 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1001582007025 carboxyltransferase (CT) interaction site; other site 1001582007026 biotinylation site [posttranslational modification]; other site 1001582007027 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1001582007028 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1001582007029 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1001582007030 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1001582007031 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1001582007032 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1001582007033 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1001582007034 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1001582007035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582007036 Walker A motif; other site 1001582007037 ATP binding site [chemical binding]; other site 1001582007038 Walker B motif; other site 1001582007039 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1001582007040 elongation factor P; Validated; Region: PRK00529 1001582007041 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1001582007042 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1001582007043 RNA binding site [nucleotide binding]; other site 1001582007044 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1001582007045 RNA binding site [nucleotide binding]; other site 1001582007046 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1001582007047 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1001582007048 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1001582007049 active site 1001582007050 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1001582007051 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1001582007052 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1001582007053 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1001582007054 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1001582007055 active site 1001582007056 nucleophile elbow; other site 1001582007057 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1001582007058 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1001582007059 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1001582007060 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1001582007061 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1001582007062 active site residue [active] 1001582007063 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1001582007064 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1001582007065 tetramer interface [polypeptide binding]; other site 1001582007066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582007067 catalytic residue [active] 1001582007068 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1001582007069 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1001582007070 tetramer interface [polypeptide binding]; other site 1001582007071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582007072 catalytic residue [active] 1001582007073 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1001582007074 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1001582007075 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1001582007076 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1001582007077 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001582007078 ATP binding site [chemical binding]; other site 1001582007079 putative Mg++ binding site [ion binding]; other site 1001582007080 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001582007081 nucleotide binding region [chemical binding]; other site 1001582007082 ATP-binding site [chemical binding]; other site 1001582007083 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1001582007084 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1001582007085 Anti-repressor SinI; Region: SinI; pfam08671 1001582007086 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001582007087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582007088 non-specific DNA binding site [nucleotide binding]; other site 1001582007089 salt bridge; other site 1001582007090 sequence-specific DNA binding site [nucleotide binding]; other site 1001582007091 Anti-repressor SinI; Region: SinI; pfam08671 1001582007092 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1001582007093 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1001582007094 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1001582007095 Catalytic site [active] 1001582007096 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1001582007097 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1001582007098 YqzE-like protein; Region: YqzE; pfam14038 1001582007099 ComG operon protein 7; Region: ComGG; pfam14173 1001582007100 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1001582007101 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1001582007102 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1001582007103 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1001582007104 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1001582007105 Type II/IV secretion system protein; Region: T2SE; pfam00437 1001582007106 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1001582007107 Walker A motif; other site 1001582007108 ATP binding site [chemical binding]; other site 1001582007109 Walker B motif; other site 1001582007110 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1001582007111 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1001582007112 Cl binding site [ion binding]; other site 1001582007113 oligomer interface [polypeptide binding]; other site 1001582007114 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1001582007115 Domain of unknown function DUF21; Region: DUF21; pfam01595 1001582007116 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1001582007117 Transporter associated domain; Region: CorC_HlyC; smart01091 1001582007118 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1001582007119 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1001582007120 ArsC family; Region: ArsC; pfam03960 1001582007121 putative catalytic residues [active] 1001582007122 thiol/disulfide switch; other site 1001582007123 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1001582007124 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1001582007125 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1001582007126 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1001582007127 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1001582007128 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1001582007129 putative active site [active] 1001582007130 Zn binding site [ion binding]; other site 1001582007131 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1001582007132 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1001582007133 nucleotide binding site [chemical binding]; other site 1001582007134 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1001582007135 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1001582007136 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1001582007137 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1001582007138 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1001582007139 YceG-like family; Region: YceG; pfam02618 1001582007140 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1001582007141 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1001582007142 Walker A/P-loop; other site 1001582007143 ATP binding site [chemical binding]; other site 1001582007144 Q-loop/lid; other site 1001582007145 ABC transporter signature motif; other site 1001582007146 Walker B; other site 1001582007147 D-loop; other site 1001582007148 H-loop/switch region; other site 1001582007149 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1001582007150 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1001582007151 Walker A/P-loop; other site 1001582007152 ATP binding site [chemical binding]; other site 1001582007153 Q-loop/lid; other site 1001582007154 ABC transporter signature motif; other site 1001582007155 Walker B; other site 1001582007156 D-loop; other site 1001582007157 H-loop/switch region; other site 1001582007158 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1001582007159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582007160 dimer interface [polypeptide binding]; other site 1001582007161 conserved gate region; other site 1001582007162 ABC-ATPase subunit interface; other site 1001582007163 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1001582007164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582007165 dimer interface [polypeptide binding]; other site 1001582007166 conserved gate region; other site 1001582007167 putative PBP binding loops; other site 1001582007168 ABC-ATPase subunit interface; other site 1001582007169 PBP superfamily domain; Region: PBP_like_2; cl17296 1001582007170 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1001582007171 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1001582007172 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1001582007173 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1001582007174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582007175 putative substrate translocation pore; other site 1001582007176 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582007177 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1001582007178 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1001582007179 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1001582007180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1001582007181 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1001582007182 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1001582007183 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1001582007184 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1001582007185 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1001582007186 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1001582007187 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1001582007188 metal binding site 2 [ion binding]; metal-binding site 1001582007189 putative DNA binding helix; other site 1001582007190 metal binding site 1 [ion binding]; metal-binding site 1001582007191 dimer interface [polypeptide binding]; other site 1001582007192 structural Zn2+ binding site [ion binding]; other site 1001582007193 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1001582007194 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001582007195 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001582007196 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1001582007197 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1001582007198 endonuclease IV; Provisional; Region: PRK01060 1001582007199 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1001582007200 AP (apurinic/apyrimidinic) site pocket; other site 1001582007201 DNA interaction; other site 1001582007202 Metal-binding active site; metal-binding site 1001582007203 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1001582007204 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1001582007205 ATP binding site [chemical binding]; other site 1001582007206 Mg++ binding site [ion binding]; other site 1001582007207 motif III; other site 1001582007208 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001582007209 nucleotide binding region [chemical binding]; other site 1001582007210 ATP-binding site [chemical binding]; other site 1001582007211 YqfQ-like protein; Region: YqfQ; pfam14181 1001582007212 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1001582007213 LytB protein; Region: LYTB; pfam02401 1001582007214 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1001582007215 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1001582007216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1001582007217 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1001582007218 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1001582007219 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1001582007220 Family of unknown function (DUF633); Region: DUF633; pfam04816 1001582007221 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1001582007222 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1001582007223 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1001582007224 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1001582007225 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1001582007226 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001582007227 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1001582007228 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582007229 DNA binding residues [nucleotide binding] 1001582007230 DNA primase; Validated; Region: dnaG; PRK05667 1001582007231 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1001582007232 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1001582007233 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1001582007234 active site 1001582007235 metal binding site [ion binding]; metal-binding site 1001582007236 interdomain interaction site; other site 1001582007237 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1001582007238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1001582007239 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1001582007240 HTH domain; Region: HTH_11; pfam08279 1001582007241 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1001582007242 FOG: CBS domain [General function prediction only]; Region: COG0517 1001582007243 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1001582007244 DALR anticodon binding domain; Region: DALR_1; pfam05746 1001582007245 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1001582007246 dimer interface [polypeptide binding]; other site 1001582007247 motif 1; other site 1001582007248 active site 1001582007249 motif 2; other site 1001582007250 motif 3; other site 1001582007251 Recombination protein O N terminal; Region: RecO_N; pfam11967 1001582007252 DNA repair protein RecO; Region: reco; TIGR00613 1001582007253 Recombination protein O C terminal; Region: RecO_C; pfam02565 1001582007254 YqzL-like protein; Region: YqzL; pfam14006 1001582007255 GTPase Era; Reviewed; Region: era; PRK00089 1001582007256 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1001582007257 G1 box; other site 1001582007258 GTP/Mg2+ binding site [chemical binding]; other site 1001582007259 Switch I region; other site 1001582007260 G2 box; other site 1001582007261 Switch II region; other site 1001582007262 G3 box; other site 1001582007263 G4 box; other site 1001582007264 G5 box; other site 1001582007265 KH domain; Region: KH_2; pfam07650 1001582007266 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1001582007267 active site 1001582007268 catalytic motif [active] 1001582007269 Zn binding site [ion binding]; other site 1001582007270 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1001582007271 metal-binding heat shock protein; Provisional; Region: PRK00016 1001582007272 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1001582007273 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1001582007274 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001582007275 Zn2+ binding site [ion binding]; other site 1001582007276 Mg2+ binding site [ion binding]; other site 1001582007277 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1001582007278 PhoH-like protein; Region: PhoH; pfam02562 1001582007279 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1001582007280 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1001582007281 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1001582007282 hypothetical protein; Provisional; Region: PRK13665 1001582007283 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1001582007284 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1001582007285 dimer interface [polypeptide binding]; other site 1001582007286 active site residues [active] 1001582007287 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1001582007288 Yqey-like protein; Region: YqeY; pfam09424 1001582007289 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1001582007290 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1001582007291 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1001582007292 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1001582007293 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1001582007294 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1001582007295 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001582007296 FeS/SAM binding site; other site 1001582007297 TRAM domain; Region: TRAM; cl01282 1001582007298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1001582007299 RNA methyltransferase, RsmE family; Region: TIGR00046 1001582007300 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1001582007301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582007302 S-adenosylmethionine binding site [chemical binding]; other site 1001582007303 chaperone protein DnaJ; Provisional; Region: PRK14280 1001582007304 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1001582007305 HSP70 interaction site [polypeptide binding]; other site 1001582007306 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1001582007307 substrate binding site [polypeptide binding]; other site 1001582007308 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1001582007309 Zn binding sites [ion binding]; other site 1001582007310 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1001582007311 dimer interface [polypeptide binding]; other site 1001582007312 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1001582007313 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1001582007314 nucleotide binding site [chemical binding]; other site 1001582007315 NEF interaction site [polypeptide binding]; other site 1001582007316 SBD interface [polypeptide binding]; other site 1001582007317 GrpE; Region: GrpE; pfam01025 1001582007318 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1001582007319 dimer interface [polypeptide binding]; other site 1001582007320 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1001582007321 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1001582007322 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1001582007323 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1001582007324 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001582007325 FeS/SAM binding site; other site 1001582007326 HemN C-terminal domain; Region: HemN_C; pfam06969 1001582007327 GTP-binding protein LepA; Provisional; Region: PRK05433 1001582007328 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1001582007329 G1 box; other site 1001582007330 putative GEF interaction site [polypeptide binding]; other site 1001582007331 GTP/Mg2+ binding site [chemical binding]; other site 1001582007332 Switch I region; other site 1001582007333 G2 box; other site 1001582007334 G3 box; other site 1001582007335 Switch II region; other site 1001582007336 G4 box; other site 1001582007337 G5 box; other site 1001582007338 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1001582007339 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1001582007340 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1001582007341 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1001582007342 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1001582007343 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1001582007344 germination protease; Provisional; Region: PRK02858 1001582007345 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1001582007346 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1001582007347 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1001582007348 YqzM-like protein; Region: YqzM; pfam14141 1001582007349 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1001582007350 catalytic motif [active] 1001582007351 Zn binding site [ion binding]; other site 1001582007352 SLBB domain; Region: SLBB; pfam10531 1001582007353 comEA protein; Region: comE; TIGR01259 1001582007354 Helix-hairpin-helix motif; Region: HHH; pfam00633 1001582007355 late competence protein ComER; Validated; Region: PRK07680 1001582007356 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1001582007357 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1001582007358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582007359 S-adenosylmethionine binding site [chemical binding]; other site 1001582007360 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1001582007361 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001582007362 Zn2+ binding site [ion binding]; other site 1001582007363 Mg2+ binding site [ion binding]; other site 1001582007364 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1001582007365 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1001582007366 active site 1001582007367 (T/H)XGH motif; other site 1001582007368 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 1001582007369 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1001582007370 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1001582007371 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1001582007372 shikimate binding site; other site 1001582007373 NAD(P) binding site [chemical binding]; other site 1001582007374 GTPase YqeH; Provisional; Region: PRK13796 1001582007375 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1001582007376 GTP/Mg2+ binding site [chemical binding]; other site 1001582007377 G4 box; other site 1001582007378 G5 box; other site 1001582007379 G1 box; other site 1001582007380 Switch I region; other site 1001582007381 G2 box; other site 1001582007382 G3 box; other site 1001582007383 Switch II region; other site 1001582007384 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1001582007385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582007386 active site 1001582007387 motif I; other site 1001582007388 motif II; other site 1001582007389 Sporulation inhibitor A; Region: Sda; pfam08970 1001582007390 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 1001582007391 active site 1001582007392 catalytic triad [active] 1001582007393 oxyanion hole [active] 1001582007394 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1001582007395 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1001582007396 NodB motif; other site 1001582007397 active site 1001582007398 catalytic site [active] 1001582007399 metal binding site [ion binding]; metal-binding site 1001582007400 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1001582007401 amidase catalytic site [active] 1001582007402 Zn binding residues [ion binding]; other site 1001582007403 substrate binding site [chemical binding]; other site 1001582007404 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1001582007405 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1001582007406 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1001582007407 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1001582007408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582007409 Coenzyme A binding pocket [chemical binding]; other site 1001582007410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582007411 putative substrate translocation pore; other site 1001582007412 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1001582007413 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1001582007414 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582007415 DNA binding residues [nucleotide binding] 1001582007416 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1001582007417 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1001582007418 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582007419 DNA binding residues [nucleotide binding] 1001582007420 hypothetical protein; Validated; Region: PRK06217 1001582007421 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1001582007422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582007423 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582007424 putative substrate translocation pore; other site 1001582007425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582007426 DinB family; Region: DinB; pfam05163 1001582007427 DinB superfamily; Region: DinB_2; pfam12867 1001582007428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1001582007429 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1001582007430 active site 1001582007431 motif I; other site 1001582007432 motif II; other site 1001582007433 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582007434 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1001582007435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582007436 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1001582007437 active site 1001582007438 motif I; other site 1001582007439 motif II; other site 1001582007440 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1001582007441 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1001582007442 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1001582007443 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1001582007444 putative active site [active] 1001582007445 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1001582007446 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1001582007447 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1001582007448 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1001582007449 active site 1001582007450 P-loop; other site 1001582007451 phosphorylation site [posttranslational modification] 1001582007452 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1001582007453 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1001582007454 active site 1001582007455 phosphorylation site [posttranslational modification] 1001582007456 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1001582007457 HTH domain; Region: HTH_11; cl17392 1001582007458 Mga helix-turn-helix domain; Region: Mga; pfam05043 1001582007459 PRD domain; Region: PRD; pfam00874 1001582007460 PRD domain; Region: PRD; pfam00874 1001582007461 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1001582007462 active site 1001582007463 P-loop; other site 1001582007464 phosphorylation site [posttranslational modification] 1001582007465 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1001582007466 active site 1001582007467 phosphorylation site [posttranslational modification] 1001582007468 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1001582007469 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1001582007470 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1001582007471 putative deacylase active site [active] 1001582007472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001582007473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001582007474 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1001582007475 putative dimerization interface [polypeptide binding]; other site 1001582007476 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1001582007477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582007478 putative substrate translocation pore; other site 1001582007479 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1001582007480 Cytochrome P450; Region: p450; pfam00067 1001582007481 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1001582007482 Flavodoxin; Region: Flavodoxin_1; pfam00258 1001582007483 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1001582007484 FAD binding pocket [chemical binding]; other site 1001582007485 FAD binding motif [chemical binding]; other site 1001582007486 catalytic residues [active] 1001582007487 NAD binding pocket [chemical binding]; other site 1001582007488 phosphate binding motif [ion binding]; other site 1001582007489 beta-alpha-beta structure motif; other site 1001582007490 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582007491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582007492 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1001582007493 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 1001582007494 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1001582007495 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1001582007496 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1001582007497 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1001582007498 catalytic loop [active] 1001582007499 iron binding site [ion binding]; other site 1001582007500 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1001582007501 4Fe-4S binding domain; Region: Fer4; pfam00037 1001582007502 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1001582007503 [4Fe-4S] binding site [ion binding]; other site 1001582007504 molybdopterin cofactor binding site; other site 1001582007505 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1001582007506 molybdopterin cofactor binding site; other site 1001582007507 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1001582007508 YrhC-like protein; Region: YrhC; pfam14143 1001582007509 cystathionine beta-lyase; Provisional; Region: PRK07671 1001582007510 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1001582007511 homodimer interface [polypeptide binding]; other site 1001582007512 substrate-cofactor binding pocket; other site 1001582007513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582007514 catalytic residue [active] 1001582007515 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1001582007516 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1001582007517 dimer interface [polypeptide binding]; other site 1001582007518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582007519 catalytic residue [active] 1001582007520 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1001582007521 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1001582007522 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1001582007523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582007524 S-adenosylmethionine binding site [chemical binding]; other site 1001582007525 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1001582007526 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1001582007527 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1001582007528 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1001582007529 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1001582007530 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1001582007531 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1001582007532 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1001582007533 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1001582007534 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1001582007535 ATP-binding site [chemical binding]; other site 1001582007536 Sugar specificity; other site 1001582007537 Pyrimidine base specificity; other site 1001582007538 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1001582007539 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1001582007540 Peptidase family U32; Region: Peptidase_U32; pfam01136 1001582007541 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1001582007542 Peptidase family U32; Region: Peptidase_U32; pfam01136 1001582007543 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1001582007544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582007545 S-adenosylmethionine binding site [chemical binding]; other site 1001582007546 conserved hypothetical protein, YceG family; Region: TIGR00247 1001582007547 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1001582007548 dimerization interface [polypeptide binding]; other site 1001582007549 hypothetical protein; Provisional; Region: PRK13678 1001582007550 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 1001582007551 hypothetical protein; Provisional; Region: PRK05473 1001582007552 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1001582007553 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1001582007554 motif 1; other site 1001582007555 active site 1001582007556 motif 2; other site 1001582007557 motif 3; other site 1001582007558 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1001582007559 DHHA1 domain; Region: DHHA1; pfam02272 1001582007560 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1001582007561 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1001582007562 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1001582007563 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1001582007564 Walker A/P-loop; other site 1001582007565 ATP binding site [chemical binding]; other site 1001582007566 Q-loop/lid; other site 1001582007567 ABC transporter signature motif; other site 1001582007568 Walker B; other site 1001582007569 D-loop; other site 1001582007570 H-loop/switch region; other site 1001582007571 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1001582007572 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1001582007573 substrate binding pocket [chemical binding]; other site 1001582007574 membrane-bound complex binding site; other site 1001582007575 hinge residues; other site 1001582007576 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1001582007577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582007578 dimer interface [polypeptide binding]; other site 1001582007579 conserved gate region; other site 1001582007580 putative PBP binding loops; other site 1001582007581 ABC-ATPase subunit interface; other site 1001582007582 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 1001582007583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582007584 dimer interface [polypeptide binding]; other site 1001582007585 ABC-ATPase subunit interface; other site 1001582007586 putative PBP binding loops; other site 1001582007587 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1001582007588 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1001582007589 AAA domain; Region: AAA_30; pfam13604 1001582007590 Family description; Region: UvrD_C_2; pfam13538 1001582007591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582007592 binding surface 1001582007593 TPR repeat; Region: TPR_11; pfam13414 1001582007594 TPR motif; other site 1001582007595 TPR repeat; Region: TPR_11; pfam13414 1001582007596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582007597 binding surface 1001582007598 TPR motif; other site 1001582007599 TPR repeat; Region: TPR_11; pfam13414 1001582007600 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1001582007601 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1001582007602 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1001582007603 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1001582007604 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001582007605 catalytic residue [active] 1001582007606 Predicted transcriptional regulator [Transcription]; Region: COG1959 1001582007607 Transcriptional regulator; Region: Rrf2; pfam02082 1001582007608 recombination factor protein RarA; Reviewed; Region: PRK13342 1001582007609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582007610 Walker A motif; other site 1001582007611 ATP binding site [chemical binding]; other site 1001582007612 Walker B motif; other site 1001582007613 arginine finger; other site 1001582007614 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1001582007615 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1001582007616 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1001582007617 putative ATP binding site [chemical binding]; other site 1001582007618 putative substrate interface [chemical binding]; other site 1001582007619 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1001582007620 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1001582007621 dimer interface [polypeptide binding]; other site 1001582007622 anticodon binding site; other site 1001582007623 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1001582007624 homodimer interface [polypeptide binding]; other site 1001582007625 motif 1; other site 1001582007626 active site 1001582007627 motif 2; other site 1001582007628 GAD domain; Region: GAD; pfam02938 1001582007629 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1001582007630 active site 1001582007631 motif 3; other site 1001582007632 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1001582007633 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1001582007634 dimer interface [polypeptide binding]; other site 1001582007635 motif 1; other site 1001582007636 active site 1001582007637 motif 2; other site 1001582007638 motif 3; other site 1001582007639 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1001582007640 anticodon binding site; other site 1001582007641 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1001582007642 Bacterial SH3 domain; Region: SH3_3; pfam08239 1001582007643 Bacterial SH3 domain; Region: SH3_3; pfam08239 1001582007644 Bacterial SH3 domain; Region: SH3_3; pfam08239 1001582007645 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1001582007646 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1001582007647 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1001582007648 active site 1001582007649 metal binding site [ion binding]; metal-binding site 1001582007650 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1001582007651 putative active site [active] 1001582007652 dimerization interface [polypeptide binding]; other site 1001582007653 putative tRNAtyr binding site [nucleotide binding]; other site 1001582007654 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1001582007655 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001582007656 Zn2+ binding site [ion binding]; other site 1001582007657 Mg2+ binding site [ion binding]; other site 1001582007658 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1001582007659 synthetase active site [active] 1001582007660 NTP binding site [chemical binding]; other site 1001582007661 metal binding site [ion binding]; metal-binding site 1001582007662 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1001582007663 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1001582007664 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001582007665 active site 1001582007666 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1001582007667 DHH family; Region: DHH; pfam01368 1001582007668 DHHA1 domain; Region: DHHA1; pfam02272 1001582007669 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1001582007670 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1001582007671 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1001582007672 TrkA-C domain; Region: TrkA_C; pfam02080 1001582007673 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1001582007674 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1001582007675 Protein export membrane protein; Region: SecD_SecF; pfam02355 1001582007676 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1001582007677 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1001582007678 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1001582007679 Predicted membrane protein [Function unknown]; Region: COG2323 1001582007680 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1001582007681 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1001582007682 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1001582007683 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1001582007684 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1001582007685 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1001582007686 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1001582007687 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1001582007688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582007689 Walker A motif; other site 1001582007690 ATP binding site [chemical binding]; other site 1001582007691 Walker B motif; other site 1001582007692 arginine finger; other site 1001582007693 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1001582007694 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1001582007695 RuvA N terminal domain; Region: RuvA_N; pfam01330 1001582007696 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1001582007697 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1001582007698 BofC C-terminal domain; Region: BofC_C; pfam08955 1001582007699 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1001582007700 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1001582007701 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582007702 quinolinate synthetase; Provisional; Region: PRK09375 1001582007703 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1001582007704 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1001582007705 dimerization interface [polypeptide binding]; other site 1001582007706 active site 1001582007707 L-aspartate oxidase; Provisional; Region: PRK08071 1001582007708 L-aspartate oxidase; Provisional; Region: PRK06175 1001582007709 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1001582007710 cysteine desulfurase; Provisional; Region: PRK02948 1001582007711 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1001582007712 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001582007713 catalytic residue [active] 1001582007714 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1001582007715 HTH domain; Region: HTH_11; pfam08279 1001582007716 3H domain; Region: 3H; pfam02829 1001582007717 prephenate dehydratase; Provisional; Region: PRK11898 1001582007718 Prephenate dehydratase; Region: PDT; pfam00800 1001582007719 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1001582007720 putative L-Phe binding site [chemical binding]; other site 1001582007721 hypothetical protein; Provisional; Region: PRK04435 1001582007722 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1001582007723 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1001582007724 GTP1/OBG; Region: GTP1_OBG; pfam01018 1001582007725 Obg GTPase; Region: Obg; cd01898 1001582007726 G1 box; other site 1001582007727 GTP/Mg2+ binding site [chemical binding]; other site 1001582007728 Switch I region; other site 1001582007729 G2 box; other site 1001582007730 G3 box; other site 1001582007731 Switch II region; other site 1001582007732 G4 box; other site 1001582007733 G5 box; other site 1001582007734 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1001582007735 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1001582007736 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1001582007737 hypothetical protein; Provisional; Region: PRK14553 1001582007738 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1001582007739 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1001582007740 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1001582007741 Peptidase family M50; Region: Peptidase_M50; pfam02163 1001582007742 active site 1001582007743 putative substrate binding region [chemical binding]; other site 1001582007744 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1001582007745 Peptidase family M23; Region: Peptidase_M23; pfam01551 1001582007746 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1001582007747 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1001582007748 Switch I; other site 1001582007749 Switch II; other site 1001582007750 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1001582007751 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1001582007752 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1001582007753 rod shape-determining protein MreC; Region: mreC; TIGR00219 1001582007754 rod shape-determining protein MreC; Region: MreC; pfam04085 1001582007755 rod shape-determining protein MreB; Provisional; Region: PRK13927 1001582007756 MreB and similar proteins; Region: MreB_like; cd10225 1001582007757 nucleotide binding site [chemical binding]; other site 1001582007758 Mg binding site [ion binding]; other site 1001582007759 putative protofilament interaction site [polypeptide binding]; other site 1001582007760 RodZ interaction site [polypeptide binding]; other site 1001582007761 hypothetical protein; Reviewed; Region: PRK00024 1001582007762 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1001582007763 MPN+ (JAMM) motif; other site 1001582007764 Zinc-binding site [ion binding]; other site 1001582007765 Maf-like protein; Region: Maf; pfam02545 1001582007766 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1001582007767 active site 1001582007768 dimer interface [polypeptide binding]; other site 1001582007769 Sporulation related domain; Region: SPOR; pfam05036 1001582007770 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1001582007771 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1001582007772 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1001582007773 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1001582007774 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001582007775 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001582007776 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1001582007777 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1001582007778 active site 1001582007779 HIGH motif; other site 1001582007780 nucleotide binding site [chemical binding]; other site 1001582007781 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1001582007782 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1001582007783 active site 1001582007784 KMSKS motif; other site 1001582007785 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1001582007786 tRNA binding surface [nucleotide binding]; other site 1001582007787 anticodon binding site; other site 1001582007788 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1001582007789 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1001582007790 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1001582007791 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1001582007792 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1001582007793 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1001582007794 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1001582007795 inhibitor-cofactor binding pocket; inhibition site 1001582007796 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582007797 catalytic residue [active] 1001582007798 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1001582007799 dimer interface [polypeptide binding]; other site 1001582007800 active site 1001582007801 Schiff base residues; other site 1001582007802 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1001582007803 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1001582007804 active site 1001582007805 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1001582007806 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1001582007807 domain interfaces; other site 1001582007808 active site 1001582007809 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 1001582007810 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1001582007811 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1001582007812 tRNA; other site 1001582007813 putative tRNA binding site [nucleotide binding]; other site 1001582007814 putative NADP binding site [chemical binding]; other site 1001582007815 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1001582007816 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1001582007817 G1 box; other site 1001582007818 GTP/Mg2+ binding site [chemical binding]; other site 1001582007819 Switch I region; other site 1001582007820 G2 box; other site 1001582007821 G3 box; other site 1001582007822 Switch II region; other site 1001582007823 G4 box; other site 1001582007824 G5 box; other site 1001582007825 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1001582007826 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1001582007827 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1001582007828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582007829 Walker A motif; other site 1001582007830 ATP binding site [chemical binding]; other site 1001582007831 Walker B motif; other site 1001582007832 arginine finger; other site 1001582007833 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1001582007834 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1001582007835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582007836 Walker A motif; other site 1001582007837 ATP binding site [chemical binding]; other site 1001582007838 Walker B motif; other site 1001582007839 arginine finger; other site 1001582007840 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1001582007841 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1001582007842 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1001582007843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582007844 Walker A motif; other site 1001582007845 ATP binding site [chemical binding]; other site 1001582007846 Walker B motif; other site 1001582007847 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1001582007848 trigger factor; Provisional; Region: tig; PRK01490 1001582007849 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1001582007850 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1001582007851 TPR repeat; Region: TPR_11; pfam13414 1001582007852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582007853 binding surface 1001582007854 TPR motif; other site 1001582007855 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1001582007856 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1001582007857 substrate binding site [chemical binding]; other site 1001582007858 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1001582007859 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1001582007860 substrate binding site [chemical binding]; other site 1001582007861 ligand binding site [chemical binding]; other site 1001582007862 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1001582007863 tartrate dehydrogenase; Region: TTC; TIGR02089 1001582007864 2-isopropylmalate synthase, bacterial type; Region: leuA_bact; TIGR00973 1001582007865 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1001582007866 active site 1001582007867 metal binding site [ion binding]; metal-binding site 1001582007868 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1001582007869 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1001582007870 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1001582007871 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1001582007872 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1001582007873 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1001582007874 putative valine binding site [chemical binding]; other site 1001582007875 dimer interface [polypeptide binding]; other site 1001582007876 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1001582007877 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1001582007878 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1001582007879 PYR/PP interface [polypeptide binding]; other site 1001582007880 dimer interface [polypeptide binding]; other site 1001582007881 TPP binding site [chemical binding]; other site 1001582007882 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1001582007883 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1001582007884 TPP-binding site [chemical binding]; other site 1001582007885 dimer interface [polypeptide binding]; other site 1001582007886 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1001582007887 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1001582007888 active site 1001582007889 metal binding site [ion binding]; metal-binding site 1001582007890 homotetramer interface [polypeptide binding]; other site 1001582007891 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1001582007892 active site 1001582007893 dimerization interface [polypeptide binding]; other site 1001582007894 ribonuclease PH; Reviewed; Region: rph; PRK00173 1001582007895 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1001582007896 hexamer interface [polypeptide binding]; other site 1001582007897 active site 1001582007898 Sporulation and spore germination; Region: Germane; pfam10646 1001582007899 Spore germination protein [General function prediction only]; Region: COG5401 1001582007900 Sporulation and spore germination; Region: Germane; pfam10646 1001582007901 glutamate racemase; Provisional; Region: PRK00865 1001582007902 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582007903 MarR family; Region: MarR; pfam01047 1001582007904 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1001582007905 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1001582007906 DNA binding residues [nucleotide binding] 1001582007907 dimerization interface [polypeptide binding]; other site 1001582007908 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1001582007909 active site 1001582007910 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1001582007911 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1001582007912 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1001582007913 L-aspartate oxidase; Provisional; Region: PRK06175 1001582007914 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1001582007915 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1001582007916 putative Iron-sulfur protein interface [polypeptide binding]; other site 1001582007917 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1001582007918 proximal heme binding site [chemical binding]; other site 1001582007919 distal heme binding site [chemical binding]; other site 1001582007920 putative dimer interface [polypeptide binding]; other site 1001582007921 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1001582007922 aspartate kinase; Reviewed; Region: PRK06635 1001582007923 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1001582007924 putative nucleotide binding site [chemical binding]; other site 1001582007925 putative catalytic residues [active] 1001582007926 putative Mg ion binding site [ion binding]; other site 1001582007927 putative aspartate binding site [chemical binding]; other site 1001582007928 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1001582007929 putative allosteric regulatory site; other site 1001582007930 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1001582007931 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1001582007932 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1001582007933 GIY-YIG motif/motif A; other site 1001582007934 active site 1001582007935 catalytic site [active] 1001582007936 putative DNA binding site [nucleotide binding]; other site 1001582007937 metal binding site [ion binding]; metal-binding site 1001582007938 UvrB/uvrC motif; Region: UVR; pfam02151 1001582007939 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1001582007940 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001582007941 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1001582007942 catalytic residues [active] 1001582007943 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1001582007944 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1001582007945 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1001582007946 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1001582007947 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1001582007948 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1001582007949 Ligand binding site [chemical binding]; other site 1001582007950 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1001582007951 enoyl-CoA hydratase; Provisional; Region: PRK07658 1001582007952 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1001582007953 substrate binding site [chemical binding]; other site 1001582007954 oxyanion hole (OAH) forming residues; other site 1001582007955 trimer interface [polypeptide binding]; other site 1001582007956 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582007957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582007958 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1001582007959 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1001582007960 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1001582007961 acyl-activating enzyme (AAE) consensus motif; other site 1001582007962 putative AMP binding site [chemical binding]; other site 1001582007963 putative active site [active] 1001582007964 putative CoA binding site [chemical binding]; other site 1001582007965 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1001582007966 Predicted membrane protein [Function unknown]; Region: COG3766 1001582007967 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1001582007968 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1001582007969 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1001582007970 MutS domain III; Region: MutS_III; pfam05192 1001582007971 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1001582007972 Walker A/P-loop; other site 1001582007973 ATP binding site [chemical binding]; other site 1001582007974 Q-loop/lid; other site 1001582007975 ABC transporter signature motif; other site 1001582007976 Walker B; other site 1001582007977 D-loop; other site 1001582007978 H-loop/switch region; other site 1001582007979 Smr domain; Region: Smr; pfam01713 1001582007980 hypothetical protein; Provisional; Region: PRK08609 1001582007981 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1001582007982 active site 1001582007983 primer binding site [nucleotide binding]; other site 1001582007984 NTP binding site [chemical binding]; other site 1001582007985 metal binding triad [ion binding]; metal-binding site 1001582007986 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1001582007987 active site 1001582007988 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1001582007989 Colicin V production protein; Region: Colicin_V; pfam02674 1001582007990 cell division protein ZapA; Provisional; Region: PRK14126 1001582007991 ribonuclease HIII; Provisional; Region: PRK00996 1001582007992 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1001582007993 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1001582007994 RNA/DNA hybrid binding site [nucleotide binding]; other site 1001582007995 active site 1001582007996 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1001582007997 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1001582007998 putative tRNA-binding site [nucleotide binding]; other site 1001582007999 B3/4 domain; Region: B3_4; pfam03483 1001582008000 tRNA synthetase B5 domain; Region: B5; smart00874 1001582008001 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1001582008002 dimer interface [polypeptide binding]; other site 1001582008003 motif 1; other site 1001582008004 motif 3; other site 1001582008005 motif 2; other site 1001582008006 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1001582008007 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1001582008008 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1001582008009 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1001582008010 dimer interface [polypeptide binding]; other site 1001582008011 motif 1; other site 1001582008012 active site 1001582008013 motif 2; other site 1001582008014 motif 3; other site 1001582008015 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1001582008016 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1001582008017 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1001582008018 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1001582008019 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1001582008020 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1001582008021 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1001582008022 FAD binding domain; Region: FAD_binding_4; pfam01565 1001582008023 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1001582008024 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1001582008025 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1001582008026 Cysteine-rich domain; Region: CCG; pfam02754 1001582008027 Cysteine-rich domain; Region: CCG; pfam02754 1001582008028 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1001582008029 Carbon starvation protein CstA; Region: CstA; pfam02554 1001582008030 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1001582008031 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1001582008032 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1001582008033 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1001582008034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582008035 dimer interface [polypeptide binding]; other site 1001582008036 conserved gate region; other site 1001582008037 putative PBP binding loops; other site 1001582008038 ABC-ATPase subunit interface; other site 1001582008039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582008040 dimer interface [polypeptide binding]; other site 1001582008041 conserved gate region; other site 1001582008042 putative PBP binding loops; other site 1001582008043 ABC-ATPase subunit interface; other site 1001582008044 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1001582008045 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1001582008046 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1001582008047 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1001582008048 active site 1001582008049 metal binding site [ion binding]; metal-binding site 1001582008050 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1001582008051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582008052 active site 1001582008053 motif I; other site 1001582008054 motif II; other site 1001582008055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582008056 motif II; other site 1001582008057 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1001582008058 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1001582008059 intersubunit interface [polypeptide binding]; other site 1001582008060 active site 1001582008061 Zn2+ binding site [ion binding]; other site 1001582008062 ribulokinase; Provisional; Region: PRK04123 1001582008063 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1001582008064 N- and C-terminal domain interface [polypeptide binding]; other site 1001582008065 active site 1001582008066 MgATP binding site [chemical binding]; other site 1001582008067 catalytic site [active] 1001582008068 metal binding site [ion binding]; metal-binding site 1001582008069 carbohydrate binding site [chemical binding]; other site 1001582008070 homodimer interface [polypeptide binding]; other site 1001582008071 L-arabinose isomerase; Provisional; Region: PRK02929 1001582008072 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1001582008073 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1001582008074 trimer interface [polypeptide binding]; other site 1001582008075 putative substrate binding site [chemical binding]; other site 1001582008076 putative metal binding site [ion binding]; other site 1001582008077 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1001582008078 substrate binding site [chemical binding]; other site 1001582008079 active site 1001582008080 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1001582008081 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1001582008082 oligomer interface [polypeptide binding]; other site 1001582008083 active site 1001582008084 metal binding site [ion binding]; metal-binding site 1001582008085 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 1001582008086 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1001582008087 23S rRNA binding site [nucleotide binding]; other site 1001582008088 L21 binding site [polypeptide binding]; other site 1001582008089 L13 binding site [polypeptide binding]; other site 1001582008090 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1001582008091 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1001582008092 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1001582008093 antiholin-like protein LrgB; Provisional; Region: PRK04288 1001582008094 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1001582008095 two-component response regulator; Provisional; Region: PRK14084 1001582008096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582008097 active site 1001582008098 phosphorylation site [posttranslational modification] 1001582008099 intermolecular recognition site; other site 1001582008100 dimerization interface [polypeptide binding]; other site 1001582008101 LytTr DNA-binding domain; Region: LytTR; smart00850 1001582008102 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1001582008103 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1001582008104 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1001582008105 Histidine kinase; Region: His_kinase; pfam06580 1001582008106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582008107 ATP binding site [chemical binding]; other site 1001582008108 Mg2+ binding site [ion binding]; other site 1001582008109 G-X-G motif; other site 1001582008110 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1001582008111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582008112 motif II; other site 1001582008113 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1001582008114 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1001582008115 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1001582008116 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1001582008117 active site 1001582008118 dimer interface [polypeptide binding]; other site 1001582008119 motif 1; other site 1001582008120 motif 2; other site 1001582008121 motif 3; other site 1001582008122 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1001582008123 anticodon binding site; other site 1001582008124 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 1001582008125 YtxC-like family; Region: YtxC; pfam08812 1001582008126 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1001582008127 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1001582008128 primosomal protein DnaI; Reviewed; Region: PRK08939 1001582008129 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1001582008130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582008131 Walker A motif; other site 1001582008132 ATP binding site [chemical binding]; other site 1001582008133 Walker B motif; other site 1001582008134 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1001582008135 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1001582008136 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1001582008137 ATP cone domain; Region: ATP-cone; pfam03477 1001582008138 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1001582008139 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1001582008140 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1001582008141 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1001582008142 Predicted transcriptional regulators [Transcription]; Region: COG1733 1001582008143 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1001582008144 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1001582008145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582008146 putative substrate translocation pore; other site 1001582008147 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001582008148 active site 1001582008149 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001582008150 catalytic tetrad [active] 1001582008151 dephospho-CoA kinase; Region: TIGR00152 1001582008152 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1001582008153 CoA-binding site [chemical binding]; other site 1001582008154 ATP-binding [chemical binding]; other site 1001582008155 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1001582008156 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1001582008157 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1001582008158 DNA binding site [nucleotide binding] 1001582008159 catalytic residue [active] 1001582008160 H2TH interface [polypeptide binding]; other site 1001582008161 putative catalytic residues [active] 1001582008162 turnover-facilitating residue; other site 1001582008163 intercalation triad [nucleotide binding]; other site 1001582008164 8OG recognition residue [nucleotide binding]; other site 1001582008165 putative reading head residues; other site 1001582008166 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1001582008167 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1001582008168 DNA polymerase I; Provisional; Region: PRK05755 1001582008169 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1001582008170 active site 1001582008171 metal binding site 1 [ion binding]; metal-binding site 1001582008172 putative 5' ssDNA interaction site; other site 1001582008173 metal binding site 3; metal-binding site 1001582008174 metal binding site 2 [ion binding]; metal-binding site 1001582008175 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1001582008176 putative DNA binding site [nucleotide binding]; other site 1001582008177 putative metal binding site [ion binding]; other site 1001582008178 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1001582008179 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1001582008180 active site 1001582008181 DNA binding site [nucleotide binding] 1001582008182 catalytic site [active] 1001582008183 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1001582008184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1001582008185 putative active site [active] 1001582008186 heme pocket [chemical binding]; other site 1001582008187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582008188 dimer interface [polypeptide binding]; other site 1001582008189 phosphorylation site [posttranslational modification] 1001582008190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582008191 ATP binding site [chemical binding]; other site 1001582008192 Mg2+ binding site [ion binding]; other site 1001582008193 G-X-G motif; other site 1001582008194 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001582008195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582008196 active site 1001582008197 phosphorylation site [posttranslational modification] 1001582008198 intermolecular recognition site; other site 1001582008199 dimerization interface [polypeptide binding]; other site 1001582008200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001582008201 DNA binding site [nucleotide binding] 1001582008202 malate dehydrogenase; Reviewed; Region: PRK06223 1001582008203 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1001582008204 NAD(P) binding site [chemical binding]; other site 1001582008205 dimer interface [polypeptide binding]; other site 1001582008206 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1001582008207 substrate binding site [chemical binding]; other site 1001582008208 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1001582008209 isocitrate dehydrogenase; Validated; Region: PRK07362 1001582008210 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1001582008211 dimer interface [polypeptide binding]; other site 1001582008212 Citrate synthase; Region: Citrate_synt; pfam00285 1001582008213 active site 1001582008214 citrylCoA binding site [chemical binding]; other site 1001582008215 oxalacetate/citrate binding site [chemical binding]; other site 1001582008216 coenzyme A binding site [chemical binding]; other site 1001582008217 catalytic triad [active] 1001582008218 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1001582008219 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1001582008220 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1001582008221 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1001582008222 pyruvate kinase; Provisional; Region: PRK06354 1001582008223 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1001582008224 domain interfaces; other site 1001582008225 active site 1001582008226 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1001582008227 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1001582008228 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1001582008229 active site 1001582008230 ADP/pyrophosphate binding site [chemical binding]; other site 1001582008231 dimerization interface [polypeptide binding]; other site 1001582008232 allosteric effector site; other site 1001582008233 fructose-1,6-bisphosphate binding site; other site 1001582008234 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1001582008235 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1001582008236 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1001582008237 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1001582008238 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1001582008239 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1001582008240 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1001582008241 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1001582008242 putative NAD(P) binding site [chemical binding]; other site 1001582008243 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1001582008244 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1001582008245 active site 1001582008246 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1001582008247 generic binding surface I; other site 1001582008248 generic binding surface II; other site 1001582008249 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1001582008250 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1001582008251 DHH family; Region: DHH; pfam01368 1001582008252 DHHA1 domain; Region: DHHA1; pfam02272 1001582008253 YtpI-like protein; Region: YtpI; pfam14007 1001582008254 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1001582008255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582008256 DNA-binding site [nucleotide binding]; DNA binding site 1001582008257 DRTGG domain; Region: DRTGG; pfam07085 1001582008258 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1001582008259 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1001582008260 active site 2 [active] 1001582008261 active site 1 [active] 1001582008262 metal-dependent hydrolase; Provisional; Region: PRK00685 1001582008263 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1001582008264 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1001582008265 classical (c) SDRs; Region: SDR_c; cd05233 1001582008266 NAD(P) binding site [chemical binding]; other site 1001582008267 active site 1001582008268 argininosuccinate lyase; Provisional; Region: PRK00855 1001582008269 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1001582008270 active sites [active] 1001582008271 tetramer interface [polypeptide binding]; other site 1001582008272 argininosuccinate synthase; Provisional; Region: PRK13820 1001582008273 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1001582008274 ANP binding site [chemical binding]; other site 1001582008275 Substrate Binding Site II [chemical binding]; other site 1001582008276 Substrate Binding Site I [chemical binding]; other site 1001582008277 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1001582008278 MPT binding site; other site 1001582008279 trimer interface [polypeptide binding]; other site 1001582008280 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1001582008281 propionate/acetate kinase; Provisional; Region: PRK12379 1001582008282 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1001582008283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582008284 S-adenosylmethionine binding site [chemical binding]; other site 1001582008285 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1001582008286 dimer interface [polypeptide binding]; other site 1001582008287 catalytic triad [active] 1001582008288 peroxidatic and resolving cysteines [active] 1001582008289 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 1001582008290 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1001582008291 RDD family; Region: RDD; pfam06271 1001582008292 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1001582008293 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1001582008294 tandem repeat interface [polypeptide binding]; other site 1001582008295 oligomer interface [polypeptide binding]; other site 1001582008296 active site residues [active] 1001582008297 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1001582008298 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1001582008299 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1001582008300 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1001582008301 active site 1001582008302 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1001582008303 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1001582008304 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1001582008305 active site 1001582008306 acyl-activating enzyme (AAE) consensus motif; other site 1001582008307 putative CoA binding site [chemical binding]; other site 1001582008308 AMP binding site [chemical binding]; other site 1001582008309 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1001582008310 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1001582008311 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1001582008312 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1001582008313 Ligand Binding Site [chemical binding]; other site 1001582008314 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1001582008315 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1001582008316 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001582008317 catalytic residue [active] 1001582008318 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1001582008319 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1001582008320 TMPIT-like protein; Region: TMPIT; pfam07851 1001582008321 histidinol-phosphatase; Reviewed; Region: PRK08123 1001582008322 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1001582008323 active site 1001582008324 dimer interface [polypeptide binding]; other site 1001582008325 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582008326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582008327 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1001582008328 GAF domain; Region: GAF_2; pfam13185 1001582008329 GAF domain; Region: GAF_3; pfam13492 1001582008330 GAF domain; Region: GAF_2; pfam13185 1001582008331 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1001582008332 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1001582008333 metal binding site [ion binding]; metal-binding site 1001582008334 active site 1001582008335 I-site; other site 1001582008336 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1001582008337 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1001582008338 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001582008339 RNA binding surface [nucleotide binding]; other site 1001582008340 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1001582008341 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1001582008342 heme-binding site [chemical binding]; other site 1001582008343 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1001582008344 FAD binding pocket [chemical binding]; other site 1001582008345 FAD binding motif [chemical binding]; other site 1001582008346 phosphate binding motif [ion binding]; other site 1001582008347 beta-alpha-beta structure motif; other site 1001582008348 NAD binding pocket [chemical binding]; other site 1001582008349 Heme binding pocket [chemical binding]; other site 1001582008350 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1001582008351 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1001582008352 active site 1001582008353 catalytic triad [active] 1001582008354 oxyanion hole [active] 1001582008355 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1001582008356 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1001582008357 Predicted transcriptional regulators [Transcription]; Region: COG1378 1001582008358 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1001582008359 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1001582008360 C-terminal domain interface [polypeptide binding]; other site 1001582008361 sugar binding site [chemical binding]; other site 1001582008362 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1001582008363 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1001582008364 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1001582008365 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1001582008366 active site 1001582008367 HIGH motif; other site 1001582008368 dimer interface [polypeptide binding]; other site 1001582008369 KMSKS motif; other site 1001582008370 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001582008371 RNA binding surface [nucleotide binding]; other site 1001582008372 acetyl-CoA synthetase; Provisional; Region: PRK04319 1001582008373 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1001582008374 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1001582008375 active site 1001582008376 acyl-activating enzyme (AAE) consensus motif; other site 1001582008377 putative CoA binding site [chemical binding]; other site 1001582008378 AMP binding site [chemical binding]; other site 1001582008379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582008380 Coenzyme A binding pocket [chemical binding]; other site 1001582008381 FOG: CBS domain [General function prediction only]; Region: COG0517 1001582008382 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1001582008383 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1001582008384 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1001582008385 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1001582008386 active site 1001582008387 Zn binding site [ion binding]; other site 1001582008388 flagellar motor protein MotS; Reviewed; Region: PRK06925 1001582008389 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1001582008390 ligand binding site [chemical binding]; other site 1001582008391 flagellar motor protein MotP; Reviewed; Region: PRK06926 1001582008392 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1001582008393 catabolite control protein A; Region: ccpA; TIGR01481 1001582008394 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001582008395 DNA binding site [nucleotide binding] 1001582008396 domain linker motif; other site 1001582008397 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1001582008398 dimerization interface [polypeptide binding]; other site 1001582008399 effector binding site; other site 1001582008400 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1001582008401 Chorismate mutase type II; Region: CM_2; cl00693 1001582008402 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1001582008403 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1001582008404 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1001582008405 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1001582008406 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1001582008407 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1001582008408 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001582008409 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1001582008410 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1001582008411 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1001582008412 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1001582008413 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1001582008414 putative tRNA-binding site [nucleotide binding]; other site 1001582008415 hypothetical protein; Provisional; Region: PRK13668 1001582008416 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001582008417 catalytic residues [active] 1001582008418 YtoQ family protein; Region: YtoQ_fam; TIGR03646 1001582008419 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1001582008420 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1001582008421 oligomer interface [polypeptide binding]; other site 1001582008422 active site 1001582008423 metal binding site [ion binding]; metal-binding site 1001582008424 Predicted small secreted protein [Function unknown]; Region: COG5584 1001582008425 malate dehydrogenase; Provisional; Region: PRK13529 1001582008426 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1001582008427 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1001582008428 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1001582008429 NAD(P) binding site [chemical binding]; other site 1001582008430 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1001582008431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582008432 S-adenosylmethionine binding site [chemical binding]; other site 1001582008433 YtzH-like protein; Region: YtzH; pfam14165 1001582008434 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1001582008435 active site 1001582008436 ATP binding site [chemical binding]; other site 1001582008437 Phosphotransferase enzyme family; Region: APH; pfam01636 1001582008438 substrate binding site [chemical binding]; other site 1001582008439 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1001582008440 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1001582008441 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1001582008442 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1001582008443 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1001582008444 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1001582008445 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1001582008446 dimer interface [polypeptide binding]; other site 1001582008447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582008448 catalytic residue [active] 1001582008449 dipeptidase PepV; Reviewed; Region: PRK07318 1001582008450 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1001582008451 active site 1001582008452 metal binding site [ion binding]; metal-binding site 1001582008453 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1001582008454 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1001582008455 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1001582008456 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1001582008457 Walker A/P-loop; other site 1001582008458 ATP binding site [chemical binding]; other site 1001582008459 Q-loop/lid; other site 1001582008460 ABC transporter signature motif; other site 1001582008461 Walker B; other site 1001582008462 D-loop; other site 1001582008463 H-loop/switch region; other site 1001582008464 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1001582008465 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1001582008466 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1001582008467 RNA binding surface [nucleotide binding]; other site 1001582008468 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1001582008469 active site 1001582008470 uracil binding [chemical binding]; other site 1001582008471 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1001582008472 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1001582008473 HI0933-like protein; Region: HI0933_like; pfam03486 1001582008474 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001582008475 BCCT family transporter; Region: BCCT; pfam02028 1001582008476 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1001582008477 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001582008478 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001582008479 DNA binding site [nucleotide binding] 1001582008480 domain linker motif; other site 1001582008481 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1001582008482 putative ligand binding site [chemical binding]; other site 1001582008483 putative dimerization interface [polypeptide binding]; other site 1001582008484 PBP superfamily domain; Region: PBP_like_2; cl17296 1001582008485 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1001582008486 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1001582008487 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1001582008488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582008489 dimer interface [polypeptide binding]; other site 1001582008490 conserved gate region; other site 1001582008491 putative PBP binding loops; other site 1001582008492 ABC-ATPase subunit interface; other site 1001582008493 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1001582008494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582008495 dimer interface [polypeptide binding]; other site 1001582008496 conserved gate region; other site 1001582008497 putative PBP binding loops; other site 1001582008498 ABC-ATPase subunit interface; other site 1001582008499 alpha-galactosidase; Provisional; Region: PRK15076 1001582008500 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1001582008501 NAD binding site [chemical binding]; other site 1001582008502 sugar binding site [chemical binding]; other site 1001582008503 divalent metal binding site [ion binding]; other site 1001582008504 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1001582008505 dimer interface [polypeptide binding]; other site 1001582008506 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1001582008507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582008508 Coenzyme A binding pocket [chemical binding]; other site 1001582008509 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1001582008510 active site residue [active] 1001582008511 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1001582008512 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1001582008513 HIGH motif; other site 1001582008514 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1001582008515 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1001582008516 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1001582008517 active site 1001582008518 KMSKS motif; other site 1001582008519 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1001582008520 tRNA binding surface [nucleotide binding]; other site 1001582008521 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1001582008522 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1001582008523 PAS domain; Region: PAS_9; pfam13426 1001582008524 putative active site [active] 1001582008525 heme pocket [chemical binding]; other site 1001582008526 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1001582008527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582008528 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582008529 putative substrate translocation pore; other site 1001582008530 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 1001582008531 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1001582008532 FtsX-like permease family; Region: FtsX; pfam02687 1001582008533 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1001582008534 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1001582008535 Walker A/P-loop; other site 1001582008536 ATP binding site [chemical binding]; other site 1001582008537 Q-loop/lid; other site 1001582008538 ABC transporter signature motif; other site 1001582008539 Walker B; other site 1001582008540 D-loop; other site 1001582008541 H-loop/switch region; other site 1001582008542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001582008543 dimer interface [polypeptide binding]; other site 1001582008544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1001582008545 phosphorylation site [posttranslational modification] 1001582008546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582008547 ATP binding site [chemical binding]; other site 1001582008548 Mg2+ binding site [ion binding]; other site 1001582008549 G-X-G motif; other site 1001582008550 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001582008551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582008552 active site 1001582008553 phosphorylation site [posttranslational modification] 1001582008554 intermolecular recognition site; other site 1001582008555 dimerization interface [polypeptide binding]; other site 1001582008556 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001582008557 DNA binding site [nucleotide binding] 1001582008558 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1001582008559 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1001582008560 FtsX-like permease family; Region: FtsX; pfam02687 1001582008561 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1001582008562 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1001582008563 Walker A/P-loop; other site 1001582008564 ATP binding site [chemical binding]; other site 1001582008565 Q-loop/lid; other site 1001582008566 ABC transporter signature motif; other site 1001582008567 Walker B; other site 1001582008568 D-loop; other site 1001582008569 H-loop/switch region; other site 1001582008570 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1001582008571 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1001582008572 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1001582008573 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1001582008574 Walker A/P-loop; other site 1001582008575 ATP binding site [chemical binding]; other site 1001582008576 Q-loop/lid; other site 1001582008577 ABC transporter signature motif; other site 1001582008578 Walker B; other site 1001582008579 D-loop; other site 1001582008580 H-loop/switch region; other site 1001582008581 Predicted transcriptional regulators [Transcription]; Region: COG1725 1001582008582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582008583 DNA-binding site [nucleotide binding]; DNA binding site 1001582008584 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1001582008585 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1001582008586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582008587 S-adenosylmethionine binding site [chemical binding]; other site 1001582008588 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1001582008589 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1001582008590 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1001582008591 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1001582008592 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1001582008593 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1001582008594 trimer interface [polypeptide binding]; other site 1001582008595 putative metal binding site [ion binding]; other site 1001582008596 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1001582008597 Spore germination protein; Region: Spore_permease; cl17796 1001582008598 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1001582008599 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1001582008600 active site 1001582008601 dimer interface [polypeptide binding]; other site 1001582008602 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1001582008603 Ligand Binding Site [chemical binding]; other site 1001582008604 Molecular Tunnel; other site 1001582008605 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1001582008606 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1001582008607 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1001582008608 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1001582008609 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1001582008610 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1001582008611 active site 1001582008612 substrate-binding site [chemical binding]; other site 1001582008613 metal-binding site [ion binding] 1001582008614 ATP binding site [chemical binding]; other site 1001582008615 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1001582008616 Dienelactone hydrolase family; Region: DLH; pfam01738 1001582008617 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1001582008618 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1001582008619 NMT1-like family; Region: NMT1_2; pfam13379 1001582008620 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1001582008621 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1001582008622 Walker A/P-loop; other site 1001582008623 ATP binding site [chemical binding]; other site 1001582008624 Q-loop/lid; other site 1001582008625 ABC transporter signature motif; other site 1001582008626 Walker B; other site 1001582008627 D-loop; other site 1001582008628 H-loop/switch region; other site 1001582008629 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1001582008630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582008631 dimer interface [polypeptide binding]; other site 1001582008632 conserved gate region; other site 1001582008633 putative PBP binding loops; other site 1001582008634 ABC-ATPase subunit interface; other site 1001582008635 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1001582008636 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1001582008637 nudix motif; other site 1001582008638 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1001582008639 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1001582008640 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1001582008641 dimerization interface [polypeptide binding]; other site 1001582008642 DPS ferroxidase diiron center [ion binding]; other site 1001582008643 ion pore; other site 1001582008644 YtkA-like; Region: YtkA; pfam13115 1001582008645 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1001582008646 Haemolytic domain; Region: Haemolytic; pfam01809 1001582008647 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1001582008648 active site clefts [active] 1001582008649 zinc binding site [ion binding]; other site 1001582008650 dimer interface [polypeptide binding]; other site 1001582008651 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1001582008652 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1001582008653 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1001582008654 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1001582008655 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1001582008656 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1001582008657 active site 1001582008658 octamer interface [polypeptide binding]; other site 1001582008659 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1001582008660 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1001582008661 acyl-activating enzyme (AAE) consensus motif; other site 1001582008662 putative AMP binding site [chemical binding]; other site 1001582008663 putative active site [active] 1001582008664 putative CoA binding site [chemical binding]; other site 1001582008665 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1001582008666 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1001582008667 substrate binding site [chemical binding]; other site 1001582008668 oxyanion hole (OAH) forming residues; other site 1001582008669 trimer interface [polypeptide binding]; other site 1001582008670 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1001582008671 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1001582008672 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1001582008673 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1001582008674 dimer interface [polypeptide binding]; other site 1001582008675 tetramer interface [polypeptide binding]; other site 1001582008676 PYR/PP interface [polypeptide binding]; other site 1001582008677 TPP binding site [chemical binding]; other site 1001582008678 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1001582008679 TPP-binding site; other site 1001582008680 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1001582008681 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1001582008682 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 1001582008683 TspO/MBR family; Region: TspO_MBR; pfam03073 1001582008684 Predicted membrane protein [Function unknown]; Region: COG3859 1001582008685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1001582008686 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1001582008687 DinB superfamily; Region: DinB_2; pfam12867 1001582008688 DinB family; Region: DinB; cl17821 1001582008689 MOSC domain; Region: MOSC; pfam03473 1001582008690 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1001582008691 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1001582008692 active site 1001582008693 NAD binding site [chemical binding]; other site 1001582008694 metal binding site [ion binding]; metal-binding site 1001582008695 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1001582008696 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1001582008697 tetramerization interface [polypeptide binding]; other site 1001582008698 NAD(P) binding site [chemical binding]; other site 1001582008699 catalytic residues [active] 1001582008700 Predicted transcriptional regulators [Transcription]; Region: COG1510 1001582008701 MarR family; Region: MarR_2; pfam12802 1001582008702 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1001582008703 TrkA-N domain; Region: TrkA_N; pfam02254 1001582008704 TrkA-C domain; Region: TrkA_C; pfam02080 1001582008705 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1001582008706 SH3-like domain; Region: SH3_8; pfam13457 1001582008707 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1001582008708 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1001582008709 heme-binding site [chemical binding]; other site 1001582008710 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1001582008711 FAD binding pocket [chemical binding]; other site 1001582008712 FAD binding motif [chemical binding]; other site 1001582008713 phosphate binding motif [ion binding]; other site 1001582008714 beta-alpha-beta structure motif; other site 1001582008715 NAD binding pocket [chemical binding]; other site 1001582008716 Heme binding pocket [chemical binding]; other site 1001582008717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1001582008718 binding surface 1001582008719 TPR motif; other site 1001582008720 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582008721 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582008722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582008723 binding surface 1001582008724 TPR motif; other site 1001582008725 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1001582008726 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1001582008727 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1001582008728 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1001582008729 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1001582008730 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1001582008731 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1001582008732 proposed catalytic triad [active] 1001582008733 conserved cys residue [active] 1001582008734 Tar ligand binding domain homologue; Region: TarH; pfam02203 1001582008735 Cache domain; Region: Cache_1; pfam02743 1001582008736 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1001582008737 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1001582008738 dimerization interface [polypeptide binding]; other site 1001582008739 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1001582008740 dimer interface [polypeptide binding]; other site 1001582008741 putative CheW interface [polypeptide binding]; other site 1001582008742 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1001582008743 Cache domain; Region: Cache_1; pfam02743 1001582008744 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1001582008745 dimerization interface [polypeptide binding]; other site 1001582008746 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1001582008747 dimer interface [polypeptide binding]; other site 1001582008748 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1001582008749 putative CheW interface [polypeptide binding]; other site 1001582008750 Tar ligand binding domain homologue; Region: TarH; pfam02203 1001582008751 Cache domain; Region: Cache_1; pfam02743 1001582008752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1001582008753 dimerization interface [polypeptide binding]; other site 1001582008754 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1001582008755 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1001582008756 dimer interface [polypeptide binding]; other site 1001582008757 putative CheW interface [polypeptide binding]; other site 1001582008758 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1001582008759 Cache domain; Region: Cache_1; pfam02743 1001582008760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1001582008761 dimerization interface [polypeptide binding]; other site 1001582008762 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1001582008763 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1001582008764 dimer interface [polypeptide binding]; other site 1001582008765 putative CheW interface [polypeptide binding]; other site 1001582008766 transglutaminase; Provisional; Region: tgl; PRK03187 1001582008767 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1001582008768 Nitronate monooxygenase; Region: NMO; pfam03060 1001582008769 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1001582008770 FMN binding site [chemical binding]; other site 1001582008771 substrate binding site [chemical binding]; other site 1001582008772 putative catalytic residue [active] 1001582008773 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1001582008774 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1001582008775 Ca binding site [ion binding]; other site 1001582008776 active site 1001582008777 catalytic site [active] 1001582008778 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1001582008779 Domain of unknown function DUF21; Region: DUF21; pfam01595 1001582008780 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1001582008781 Transporter associated domain; Region: CorC_HlyC; smart01091 1001582008782 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1001582008783 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1001582008784 Ion channel; Region: Ion_trans_2; pfam07885 1001582008785 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1001582008786 TrkA-N domain; Region: TrkA_N; pfam02254 1001582008787 YugN-like family; Region: YugN; pfam08868 1001582008788 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1001582008789 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1001582008790 active site 1001582008791 dimer interface [polypeptide binding]; other site 1001582008792 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1001582008793 dimer interface [polypeptide binding]; other site 1001582008794 active site 1001582008795 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1001582008796 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1001582008797 dimer interface [polypeptide binding]; other site 1001582008798 active site 1001582008799 metal binding site [ion binding]; metal-binding site 1001582008800 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1001582008801 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1001582008802 dimer interface [polypeptide binding]; other site 1001582008803 active site 1001582008804 metal binding site [ion binding]; metal-binding site 1001582008805 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1001582008806 general stress protein 13; Validated; Region: PRK08059 1001582008807 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1001582008808 RNA binding site [nucleotide binding]; other site 1001582008809 hypothetical protein; Validated; Region: PRK07682 1001582008810 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001582008811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582008812 homodimer interface [polypeptide binding]; other site 1001582008813 catalytic residue [active] 1001582008814 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1001582008815 AsnC family; Region: AsnC_trans_reg; pfam01037 1001582008816 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1001582008817 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1001582008818 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1001582008819 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001582008820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582008821 homodimer interface [polypeptide binding]; other site 1001582008822 catalytic residue [active] 1001582008823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001582008824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582008825 dimer interface [polypeptide binding]; other site 1001582008826 phosphorylation site [posttranslational modification] 1001582008827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582008828 ATP binding site [chemical binding]; other site 1001582008829 Mg2+ binding site [ion binding]; other site 1001582008830 G-X-G motif; other site 1001582008831 Kinase associated protein B; Region: KapB; pfam08810 1001582008832 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1001582008833 active site 1001582008834 catalytic site [active] 1001582008835 substrate binding site [chemical binding]; other site 1001582008836 sugar efflux transporter; Region: 2A0120; TIGR00899 1001582008837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582008838 putative substrate translocation pore; other site 1001582008839 Transglycosylase; Region: Transgly; pfam00912 1001582008840 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1001582008841 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1001582008842 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1001582008843 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1001582008844 PAS domain; Region: PAS; smart00091 1001582008845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582008846 ATP binding site [chemical binding]; other site 1001582008847 Mg2+ binding site [ion binding]; other site 1001582008848 G-X-G motif; other site 1001582008849 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1001582008850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582008851 active site 1001582008852 phosphorylation site [posttranslational modification] 1001582008853 intermolecular recognition site; other site 1001582008854 dimerization interface [polypeptide binding]; other site 1001582008855 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1001582008856 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1001582008857 ligand binding site [chemical binding]; other site 1001582008858 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1001582008859 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1001582008860 Walker A/P-loop; other site 1001582008861 ATP binding site [chemical binding]; other site 1001582008862 Q-loop/lid; other site 1001582008863 ABC transporter signature motif; other site 1001582008864 Walker B; other site 1001582008865 D-loop; other site 1001582008866 H-loop/switch region; other site 1001582008867 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1001582008868 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1001582008869 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1001582008870 TM-ABC transporter signature motif; other site 1001582008871 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1001582008872 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1001582008873 TM-ABC transporter signature motif; other site 1001582008874 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1001582008875 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1001582008876 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1001582008877 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1001582008878 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1001582008879 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1001582008880 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1001582008881 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1001582008882 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1001582008883 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1001582008884 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1001582008885 CoenzymeA binding site [chemical binding]; other site 1001582008886 subunit interaction site [polypeptide binding]; other site 1001582008887 PHB binding site; other site 1001582008888 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1001582008889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582008890 active site 1001582008891 phosphorylation site [posttranslational modification] 1001582008892 intermolecular recognition site; other site 1001582008893 dimerization interface [polypeptide binding]; other site 1001582008894 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1001582008895 DNA binding residues [nucleotide binding] 1001582008896 dimerization interface [polypeptide binding]; other site 1001582008897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1001582008898 Histidine kinase; Region: HisKA_3; pfam07730 1001582008899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582008900 ATP binding site [chemical binding]; other site 1001582008901 Mg2+ binding site [ion binding]; other site 1001582008902 G-X-G motif; other site 1001582008903 Bacillus competence pheromone ComX; Region: ComX; pfam05952 1001582008904 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1001582008905 aspartate-rich region 2; other site 1001582008906 DegQ (SacQ) family; Region: DegQ; pfam08181 1001582008907 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1001582008908 EAL domain; Region: EAL; pfam00563 1001582008909 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1001582008910 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1001582008911 active site 1001582008912 Isochorismatase family; Region: Isochorismatase; pfam00857 1001582008913 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1001582008914 catalytic triad [active] 1001582008915 conserved cis-peptide bond; other site 1001582008916 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1001582008917 YueH-like protein; Region: YueH; pfam14166 1001582008918 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1001582008919 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1001582008920 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1001582008921 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1001582008922 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1001582008923 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001582008924 Zn2+ binding site [ion binding]; other site 1001582008925 Mg2+ binding site [ion binding]; other site 1001582008926 short chain dehydrogenase; Provisional; Region: PRK06924 1001582008927 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1001582008928 NADP binding site [chemical binding]; other site 1001582008929 homodimer interface [polypeptide binding]; other site 1001582008930 active site 1001582008931 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1001582008932 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1001582008933 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1001582008934 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1001582008935 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1001582008936 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1001582008937 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1001582008938 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1001582008939 Domain of unknown function DUF87; Region: DUF87; pfam01935 1001582008940 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1001582008941 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 1001582008942 Uncharacterized small protein [Function unknown]; Region: COG5417 1001582008943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1001582008944 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1001582008945 CodY GAF-like domain; Region: CodY; pfam06018 1001582008946 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1001582008947 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1001582008948 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1001582008949 hexamer interface [polypeptide binding]; other site 1001582008950 ligand binding site [chemical binding]; other site 1001582008951 putative active site [active] 1001582008952 NAD(P) binding site [chemical binding]; other site 1001582008953 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1001582008954 MbtH-like protein; Region: MbtH; cl01279 1001582008955 Condensation domain; Region: Condensation; pfam00668 1001582008956 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1001582008957 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1001582008958 acyl-activating enzyme (AAE) consensus motif; other site 1001582008959 AMP binding site [chemical binding]; other site 1001582008960 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582008961 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1001582008962 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1001582008963 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1001582008964 acyl-activating enzyme (AAE) consensus motif; other site 1001582008965 AMP binding site [chemical binding]; other site 1001582008966 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1001582008967 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1001582008968 hydrophobic substrate binding pocket; other site 1001582008969 Isochorismatase family; Region: Isochorismatase; pfam00857 1001582008970 active site 1001582008971 conserved cis-peptide bond; other site 1001582008972 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1001582008973 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1001582008974 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1001582008975 acyl-activating enzyme (AAE) consensus motif; other site 1001582008976 active site 1001582008977 AMP binding site [chemical binding]; other site 1001582008978 substrate binding site [chemical binding]; other site 1001582008979 isochorismate synthase DhbC; Validated; Region: PRK06923 1001582008980 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1001582008981 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1001582008982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001582008983 NAD(P) binding site [chemical binding]; other site 1001582008984 active site 1001582008985 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1001582008986 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1001582008987 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1001582008988 Moco binding site; other site 1001582008989 metal coordination site [ion binding]; other site 1001582008990 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1001582008991 Predicted permease [General function prediction only]; Region: COG2056 1001582008992 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1001582008993 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1001582008994 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1001582008995 interface (dimer of trimers) [polypeptide binding]; other site 1001582008996 Substrate-binding/catalytic site; other site 1001582008997 Zn-binding sites [ion binding]; other site 1001582008998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 1001582008999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1001582009000 Putative membrane protein; Region: YuiB; pfam14068 1001582009001 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1001582009002 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001582009003 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1001582009004 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001582009005 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001582009006 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1001582009007 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1001582009008 active site 1001582009009 Integral membrane protein DUF95; Region: DUF95; pfam01944 1001582009010 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1001582009011 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1001582009012 Walker A/P-loop; other site 1001582009013 ATP binding site [chemical binding]; other site 1001582009014 Q-loop/lid; other site 1001582009015 ABC transporter signature motif; other site 1001582009016 Walker B; other site 1001582009017 D-loop; other site 1001582009018 H-loop/switch region; other site 1001582009019 potential frameshift: common BLAST hit: gi|163119282|ref|YP_077962.2| ribosomal-protein-alanine N-acetyltransferase YjcK 1001582009020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1001582009021 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1001582009022 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1001582009023 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1001582009024 putative NAD(P) binding site [chemical binding]; other site 1001582009025 active site 1001582009026 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1001582009027 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1001582009028 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1001582009029 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1001582009030 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1001582009031 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1001582009032 Nucleoside recognition; Region: Gate; pfam07670 1001582009033 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1001582009034 hypothetical protein; Provisional; Region: PRK13669 1001582009035 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1001582009036 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001582009037 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 1001582009038 NifU-like domain; Region: NifU; pfam01106 1001582009039 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1001582009040 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1001582009041 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1001582009042 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1001582009043 homoserine kinase; Region: thrB; TIGR00191 1001582009044 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1001582009045 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1001582009046 threonine synthase; Reviewed; Region: PRK06721 1001582009047 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1001582009048 homodimer interface [polypeptide binding]; other site 1001582009049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582009050 catalytic residue [active] 1001582009051 homoserine dehydrogenase; Provisional; Region: PRK06349 1001582009052 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1001582009053 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1001582009054 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1001582009055 spore coat protein YutH; Region: spore_yutH; TIGR02905 1001582009056 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1001582009057 tetramer interfaces [polypeptide binding]; other site 1001582009058 binuclear metal-binding site [ion binding]; other site 1001582009059 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1001582009060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582009061 active site 1001582009062 motif I; other site 1001582009063 motif II; other site 1001582009064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582009065 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1001582009066 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1001582009067 lipoyl synthase; Provisional; Region: PRK05481 1001582009068 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001582009069 FeS/SAM binding site; other site 1001582009070 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1001582009071 Peptidase family M23; Region: Peptidase_M23; pfam01551 1001582009072 sporulation protein YunB; Region: spo_yunB; TIGR02832 1001582009073 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1001582009074 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1001582009075 active site 1001582009076 metal binding site [ion binding]; metal-binding site 1001582009077 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1001582009078 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1001582009079 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1001582009080 allantoinase; Provisional; Region: PRK06189 1001582009081 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1001582009082 active site 1001582009083 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1001582009084 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1001582009085 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1001582009086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582009087 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582009088 putative substrate translocation pore; other site 1001582009089 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1001582009090 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001582009091 catalytic residue [active] 1001582009092 allantoate amidohydrolase; Reviewed; Region: PRK09290 1001582009093 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1001582009094 active site 1001582009095 metal binding site [ion binding]; metal-binding site 1001582009096 dimer interface [polypeptide binding]; other site 1001582009097 Endonuclease I; Region: Endonuclease_1; pfam04231 1001582009098 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1001582009099 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1001582009100 Walker A/P-loop; other site 1001582009101 ATP binding site [chemical binding]; other site 1001582009102 Q-loop/lid; other site 1001582009103 ABC transporter signature motif; other site 1001582009104 Walker B; other site 1001582009105 D-loop; other site 1001582009106 H-loop/switch region; other site 1001582009107 TOBE domain; Region: TOBE_2; pfam08402 1001582009108 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1001582009109 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582009110 DNA-binding site [nucleotide binding]; DNA binding site 1001582009111 UTRA domain; Region: UTRA; pfam07702 1001582009112 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1001582009113 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1001582009114 substrate binding site [chemical binding]; other site 1001582009115 ATP binding site [chemical binding]; other site 1001582009116 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1001582009117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582009118 dimer interface [polypeptide binding]; other site 1001582009119 conserved gate region; other site 1001582009120 putative PBP binding loops; other site 1001582009121 ABC-ATPase subunit interface; other site 1001582009122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582009123 dimer interface [polypeptide binding]; other site 1001582009124 conserved gate region; other site 1001582009125 putative PBP binding loops; other site 1001582009126 ABC-ATPase subunit interface; other site 1001582009127 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1001582009128 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1001582009129 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1001582009130 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1001582009131 putative active site [active] 1001582009132 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1001582009133 dimer interface [polypeptide binding]; other site 1001582009134 active site 1001582009135 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1001582009136 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1001582009137 DNA binding residues [nucleotide binding] 1001582009138 dimer interface [polypeptide binding]; other site 1001582009139 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1001582009140 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1001582009141 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 1001582009142 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1001582009143 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1001582009144 GIY-YIG motif/motif A; other site 1001582009145 active site 1001582009146 catalytic site [active] 1001582009147 putative DNA binding site [nucleotide binding]; other site 1001582009148 metal binding site [ion binding]; metal-binding site 1001582009149 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1001582009150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582009151 S-adenosylmethionine binding site [chemical binding]; other site 1001582009152 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1001582009153 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1001582009154 chitosan binding site [chemical binding]; other site 1001582009155 catalytic residues [active] 1001582009156 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1001582009157 substrate binding site [chemical binding]; other site 1001582009158 amidase catalytic site [active] 1001582009159 Zn binding residues [ion binding]; other site 1001582009160 Bacterial SH3 domain; Region: SH3_3; pfam08239 1001582009161 Holin family; Region: Phage_holin_4; cl01989 1001582009162 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 1001582009163 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1001582009164 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1001582009165 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1001582009166 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1001582009167 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1001582009168 Phage tail protein; Region: Sipho_tail; pfam05709 1001582009169 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 1001582009170 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1001582009171 Phage-related protein [Function unknown]; Region: COG5412 1001582009172 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1001582009173 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1001582009174 catalytic residue [active] 1001582009175 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1001582009176 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1001582009177 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1001582009178 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1001582009179 oligomerization interface [polypeptide binding]; other site 1001582009180 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1001582009181 Phage capsid family; Region: Phage_capsid; pfam05065 1001582009182 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1001582009183 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1001582009184 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1001582009185 Phage Terminase; Region: Terminase_1; pfam03354 1001582009186 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1001582009187 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1001582009188 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1001582009189 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1001582009190 ATP binding site [chemical binding]; other site 1001582009191 putative Mg++ binding site [ion binding]; other site 1001582009192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001582009193 nucleotide binding region [chemical binding]; other site 1001582009194 ATP-binding site [chemical binding]; other site 1001582009195 VRR-NUC domain; Region: VRR_NUC; pfam08774 1001582009196 Virulence-associated protein E; Region: VirE; pfam05272 1001582009197 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1001582009198 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1001582009199 cofactor binding site; other site 1001582009200 DNA binding site [nucleotide binding] 1001582009201 substrate interaction site [chemical binding]; other site 1001582009202 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 1001582009203 DNA binding site [nucleotide binding] 1001582009204 active site 1001582009205 catalytic site [active] 1001582009206 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1001582009207 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 1001582009208 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 1001582009209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1001582009210 non-specific DNA binding site [nucleotide binding]; other site 1001582009211 salt bridge; other site 1001582009212 sequence-specific DNA binding site [nucleotide binding]; other site 1001582009213 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582009214 sequence-specific DNA binding site [nucleotide binding]; other site 1001582009215 salt bridge; other site 1001582009216 Domain of unknown function (DUF955); Region: DUF955; cl01076 1001582009217 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1001582009218 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1001582009219 Int/Topo IB signature motif; other site 1001582009220 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1001582009221 FeS assembly protein SufB; Region: sufB; TIGR01980 1001582009222 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1001582009223 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1001582009224 trimerization site [polypeptide binding]; other site 1001582009225 active site 1001582009226 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1001582009227 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1001582009228 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001582009229 catalytic residue [active] 1001582009230 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1001582009231 FeS assembly protein SufD; Region: sufD; TIGR01981 1001582009232 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1001582009233 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1001582009234 Walker A/P-loop; other site 1001582009235 ATP binding site [chemical binding]; other site 1001582009236 Q-loop/lid; other site 1001582009237 ABC transporter signature motif; other site 1001582009238 Walker B; other site 1001582009239 D-loop; other site 1001582009240 H-loop/switch region; other site 1001582009241 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1001582009242 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1001582009243 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1001582009244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582009245 dimer interface [polypeptide binding]; other site 1001582009246 conserved gate region; other site 1001582009247 ABC-ATPase subunit interface; other site 1001582009248 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1001582009249 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1001582009250 Walker A/P-loop; other site 1001582009251 ATP binding site [chemical binding]; other site 1001582009252 Q-loop/lid; other site 1001582009253 ABC transporter signature motif; other site 1001582009254 Walker B; other site 1001582009255 D-loop; other site 1001582009256 H-loop/switch region; other site 1001582009257 NIL domain; Region: NIL; pfam09383 1001582009258 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1001582009259 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1001582009260 catalytic residues [active] 1001582009261 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1001582009262 putative active site [active] 1001582009263 putative metal binding site [ion binding]; other site 1001582009264 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1001582009265 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1001582009266 lipoyl attachment site [posttranslational modification]; other site 1001582009267 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1001582009268 ArsC family; Region: ArsC; pfam03960 1001582009269 putative ArsC-like catalytic residues; other site 1001582009270 putative TRX-like catalytic residues [active] 1001582009271 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1001582009272 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1001582009273 active site 1001582009274 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1001582009275 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1001582009276 dimer interface [polypeptide binding]; other site 1001582009277 active site 1001582009278 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1001582009279 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1001582009280 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1001582009281 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1001582009282 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1001582009283 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1001582009284 substrate binding site [chemical binding]; other site 1001582009285 oxyanion hole (OAH) forming residues; other site 1001582009286 trimer interface [polypeptide binding]; other site 1001582009287 YuzL-like protein; Region: YuzL; pfam14115 1001582009288 Proline dehydrogenase; Region: Pro_dh; cl03282 1001582009289 Pyruvate formate lyase; Region: PFL; pfam02901 1001582009290 Coat F domain; Region: Coat_F; pfam07875 1001582009291 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582009292 MarR family; Region: MarR; pfam01047 1001582009293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582009294 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582009295 putative substrate translocation pore; other site 1001582009296 Restriction endonuclease BamHI; Region: BamHI; pfam02923 1001582009297 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001582009298 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582009299 non-specific DNA binding site [nucleotide binding]; other site 1001582009300 salt bridge; other site 1001582009301 sequence-specific DNA binding site [nucleotide binding]; other site 1001582009302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582009303 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1001582009304 DNA methylase; Region: N6_N4_Mtase; pfam01555 1001582009305 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1001582009306 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1001582009307 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1001582009308 Walker A/P-loop; other site 1001582009309 ATP binding site [chemical binding]; other site 1001582009310 Q-loop/lid; other site 1001582009311 ABC transporter signature motif; other site 1001582009312 Walker B; other site 1001582009313 D-loop; other site 1001582009314 H-loop/switch region; other site 1001582009315 YusW-like protein; Region: YusW; pfam14039 1001582009316 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1001582009317 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1001582009318 active site 1001582009319 Zn binding site [ion binding]; other site 1001582009320 short chain dehydrogenase; Provisional; Region: PRK06914 1001582009321 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1001582009322 NADP binding site [chemical binding]; other site 1001582009323 active site 1001582009324 steroid binding site; other site 1001582009325 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1001582009326 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1001582009327 dimerization interface [polypeptide binding]; other site 1001582009328 DPS ferroxidase diiron center [ion binding]; other site 1001582009329 ion pore; other site 1001582009330 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1001582009331 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1001582009332 protein binding site [polypeptide binding]; other site 1001582009333 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001582009334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582009335 active site 1001582009336 phosphorylation site [posttranslational modification] 1001582009337 intermolecular recognition site; other site 1001582009338 dimerization interface [polypeptide binding]; other site 1001582009339 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001582009340 DNA binding site [nucleotide binding] 1001582009341 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001582009342 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1001582009343 dimerization interface [polypeptide binding]; other site 1001582009344 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582009345 dimer interface [polypeptide binding]; other site 1001582009346 phosphorylation site [posttranslational modification] 1001582009347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582009348 ATP binding site [chemical binding]; other site 1001582009349 Mg2+ binding site [ion binding]; other site 1001582009350 G-X-G motif; other site 1001582009351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582009352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582009353 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1001582009354 Class II fumarases; Region: Fumarase_classII; cd01362 1001582009355 active site 1001582009356 tetramer interface [polypeptide binding]; other site 1001582009357 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1001582009358 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1001582009359 Spore germination protein; Region: Spore_permease; pfam03845 1001582009360 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1001582009361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582009362 active site 1001582009363 phosphorylation site [posttranslational modification] 1001582009364 intermolecular recognition site; other site 1001582009365 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1001582009366 DNA binding residues [nucleotide binding] 1001582009367 dimerization interface [polypeptide binding]; other site 1001582009368 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1001582009369 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1001582009370 dimerization interface [polypeptide binding]; other site 1001582009371 Histidine kinase; Region: HisKA_3; pfam07730 1001582009372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582009373 ATP binding site [chemical binding]; other site 1001582009374 Mg2+ binding site [ion binding]; other site 1001582009375 G-X-G motif; other site 1001582009376 Predicted membrane protein [Function unknown]; Region: COG4758 1001582009377 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1001582009378 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1001582009379 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1001582009380 PspA/IM30 family; Region: PspA_IM30; pfam04012 1001582009381 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1001582009382 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1001582009383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582009384 H+ Antiporter protein; Region: 2A0121; TIGR00900 1001582009385 putative substrate translocation pore; other site 1001582009386 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1001582009387 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1001582009388 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1001582009389 Walker A/P-loop; other site 1001582009390 ATP binding site [chemical binding]; other site 1001582009391 Q-loop/lid; other site 1001582009392 ABC transporter signature motif; other site 1001582009393 Walker B; other site 1001582009394 D-loop; other site 1001582009395 H-loop/switch region; other site 1001582009396 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 1001582009397 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1001582009398 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1001582009399 ABC-ATPase subunit interface; other site 1001582009400 dimer interface [polypeptide binding]; other site 1001582009401 putative PBP binding regions; other site 1001582009402 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1001582009403 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1001582009404 putative binding site residues; other site 1001582009405 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1001582009406 classical (c) SDRs; Region: SDR_c; cd05233 1001582009407 NAD(P) binding site [chemical binding]; other site 1001582009408 active site 1001582009409 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1001582009410 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1001582009411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582009412 dimer interface [polypeptide binding]; other site 1001582009413 phosphorylation site [posttranslational modification] 1001582009414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582009415 ATP binding site [chemical binding]; other site 1001582009416 Mg2+ binding site [ion binding]; other site 1001582009417 G-X-G motif; other site 1001582009418 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001582009419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582009420 active site 1001582009421 phosphorylation site [posttranslational modification] 1001582009422 intermolecular recognition site; other site 1001582009423 dimerization interface [polypeptide binding]; other site 1001582009424 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001582009425 DNA binding site [nucleotide binding] 1001582009426 hypothetical protein; Provisional; Region: PRK14082 1001582009427 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1001582009428 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1001582009429 DNA binding residues [nucleotide binding] 1001582009430 YvrJ protein family; Region: YvrJ; pfam12841 1001582009431 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1001582009432 Cupin; Region: Cupin_1; smart00835 1001582009433 Cupin; Region: Cupin_1; smart00835 1001582009434 Regulatory protein YrvL; Region: YrvL; pfam14184 1001582009435 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1001582009436 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1001582009437 Walker A/P-loop; other site 1001582009438 ATP binding site [chemical binding]; other site 1001582009439 Q-loop/lid; other site 1001582009440 ABC transporter signature motif; other site 1001582009441 Walker B; other site 1001582009442 D-loop; other site 1001582009443 H-loop/switch region; other site 1001582009444 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1001582009445 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1001582009446 ABC-ATPase subunit interface; other site 1001582009447 dimer interface [polypeptide binding]; other site 1001582009448 putative PBP binding regions; other site 1001582009449 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1001582009450 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1001582009451 ABC-ATPase subunit interface; other site 1001582009452 dimer interface [polypeptide binding]; other site 1001582009453 putative PBP binding regions; other site 1001582009454 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1001582009455 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1001582009456 putative ligand binding residues [chemical binding]; other site 1001582009457 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1001582009458 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1001582009459 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 1001582009460 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1001582009461 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1001582009462 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1001582009463 Sulfatase; Region: Sulfatase; cl17466 1001582009464 DNA binding domain, excisionase family; Region: excise; TIGR01764 1001582009465 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 1001582009466 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1001582009467 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1001582009468 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1001582009469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582009470 dimer interface [polypeptide binding]; other site 1001582009471 conserved gate region; other site 1001582009472 putative PBP binding loops; other site 1001582009473 ABC-ATPase subunit interface; other site 1001582009474 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1001582009475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582009476 active site 1001582009477 phosphorylation site [posttranslational modification] 1001582009478 intermolecular recognition site; other site 1001582009479 dimerization interface [polypeptide binding]; other site 1001582009480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1001582009481 DNA binding residues [nucleotide binding] 1001582009482 dimerization interface [polypeptide binding]; other site 1001582009483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1001582009484 Histidine kinase; Region: HisKA_3; pfam07730 1001582009485 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1001582009486 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1001582009487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582009488 Walker A/P-loop; other site 1001582009489 ATP binding site [chemical binding]; other site 1001582009490 Q-loop/lid; other site 1001582009491 ABC transporter signature motif; other site 1001582009492 Walker B; other site 1001582009493 D-loop; other site 1001582009494 H-loop/switch region; other site 1001582009495 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1001582009496 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1001582009497 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1001582009498 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1001582009499 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1001582009500 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001582009501 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001582009502 active site 1001582009503 catalytic tetrad [active] 1001582009504 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1001582009505 sulfite reductase subunit beta; Provisional; Region: PRK13504 1001582009506 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1001582009507 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1001582009508 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1001582009509 Flavodoxin; Region: Flavodoxin_1; pfam00258 1001582009510 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1001582009511 FAD binding pocket [chemical binding]; other site 1001582009512 FAD binding motif [chemical binding]; other site 1001582009513 catalytic residues [active] 1001582009514 NAD binding pocket [chemical binding]; other site 1001582009515 phosphate binding motif [ion binding]; other site 1001582009516 beta-alpha-beta structure motif; other site 1001582009517 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1001582009518 Family description; Region: UvrD_C_2; pfam13538 1001582009519 Predicted membrane protein [Function unknown]; Region: COG2860 1001582009520 UPF0126 domain; Region: UPF0126; pfam03458 1001582009521 UPF0126 domain; Region: UPF0126; pfam03458 1001582009522 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 1001582009523 active site 1001582009524 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1001582009525 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1001582009526 Thioredoxin; Region: Thioredoxin_4; pfam13462 1001582009527 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1001582009528 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1001582009529 metal-binding site [ion binding] 1001582009530 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1001582009531 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1001582009532 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1001582009533 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1001582009534 metal-binding site [ion binding] 1001582009535 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1001582009536 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1001582009537 metal-binding site [ion binding] 1001582009538 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1001582009539 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1001582009540 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1001582009541 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1001582009542 metal-binding site [ion binding] 1001582009543 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1001582009544 putative homodimer interface [polypeptide binding]; other site 1001582009545 putative homotetramer interface [polypeptide binding]; other site 1001582009546 putative allosteric switch controlling residues; other site 1001582009547 putative metal binding site [ion binding]; other site 1001582009548 putative homodimer-homodimer interface [polypeptide binding]; other site 1001582009549 putative oxidoreductase; Provisional; Region: PRK11579 1001582009550 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1001582009551 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1001582009552 azoreductase; Reviewed; Region: PRK00170 1001582009553 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1001582009554 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1001582009555 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1001582009556 active site 1001582009557 non-prolyl cis peptide bond; other site 1001582009558 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1001582009559 catalytic residues [active] 1001582009560 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1001582009561 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1001582009562 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1001582009563 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1001582009564 Walker A/P-loop; other site 1001582009565 ATP binding site [chemical binding]; other site 1001582009566 Q-loop/lid; other site 1001582009567 ABC transporter signature motif; other site 1001582009568 Walker B; other site 1001582009569 D-loop; other site 1001582009570 H-loop/switch region; other site 1001582009571 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1001582009572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582009573 dimer interface [polypeptide binding]; other site 1001582009574 conserved gate region; other site 1001582009575 putative PBP binding loops; other site 1001582009576 ABC-ATPase subunit interface; other site 1001582009577 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 1001582009578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582009579 dimer interface [polypeptide binding]; other site 1001582009580 conserved gate region; other site 1001582009581 putative PBP binding loops; other site 1001582009582 ABC-ATPase subunit interface; other site 1001582009583 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1001582009584 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1001582009585 substrate binding pocket [chemical binding]; other site 1001582009586 membrane-bound complex binding site; other site 1001582009587 hinge residues; other site 1001582009588 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1001582009589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582009590 Coenzyme A binding pocket [chemical binding]; other site 1001582009591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001582009592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001582009593 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1001582009594 dimerization interface [polypeptide binding]; other site 1001582009595 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1001582009596 classical (c) SDRs; Region: SDR_c; cd05233 1001582009597 NAD(P) binding site [chemical binding]; other site 1001582009598 active site 1001582009599 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1001582009600 RNAase interaction site [polypeptide binding]; other site 1001582009601 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1001582009602 SmpB-tmRNA interface; other site 1001582009603 ribonuclease R; Region: RNase_R; TIGR02063 1001582009604 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1001582009605 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1001582009606 RNB domain; Region: RNB; pfam00773 1001582009607 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1001582009608 RNA binding site [nucleotide binding]; other site 1001582009609 Esterase/lipase [General function prediction only]; Region: COG1647 1001582009610 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1001582009611 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1001582009612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582009613 salt bridge; other site 1001582009614 non-specific DNA binding site [nucleotide binding]; other site 1001582009615 sequence-specific DNA binding site [nucleotide binding]; other site 1001582009616 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001582009617 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582009618 non-specific DNA binding site [nucleotide binding]; other site 1001582009619 salt bridge; other site 1001582009620 sequence-specific DNA binding site [nucleotide binding]; other site 1001582009621 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001582009622 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582009623 non-specific DNA binding site [nucleotide binding]; other site 1001582009624 salt bridge; other site 1001582009625 sequence-specific DNA binding site [nucleotide binding]; other site 1001582009626 Predicted transcriptional regulators [Transcription]; Region: COG1733 1001582009627 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582009628 dimerization interface [polypeptide binding]; other site 1001582009629 putative DNA binding site [nucleotide binding]; other site 1001582009630 putative Zn2+ binding site [ion binding]; other site 1001582009631 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001582009632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582009633 dimer interface [polypeptide binding]; other site 1001582009634 phosphorylation site [posttranslational modification] 1001582009635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582009636 ATP binding site [chemical binding]; other site 1001582009637 Mg2+ binding site [ion binding]; other site 1001582009638 G-X-G motif; other site 1001582009639 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001582009640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582009641 active site 1001582009642 phosphorylation site [posttranslational modification] 1001582009643 intermolecular recognition site; other site 1001582009644 dimerization interface [polypeptide binding]; other site 1001582009645 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001582009646 DNA binding site [nucleotide binding] 1001582009647 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1001582009648 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1001582009649 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1001582009650 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1001582009651 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1001582009652 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1001582009653 Walker A/P-loop; other site 1001582009654 ATP binding site [chemical binding]; other site 1001582009655 Q-loop/lid; other site 1001582009656 ABC transporter signature motif; other site 1001582009657 Walker B; other site 1001582009658 D-loop; other site 1001582009659 H-loop/switch region; other site 1001582009660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582009661 dimer interface [polypeptide binding]; other site 1001582009662 conserved gate region; other site 1001582009663 putative PBP binding loops; other site 1001582009664 ABC-ATPase subunit interface; other site 1001582009665 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1001582009666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582009667 dimer interface [polypeptide binding]; other site 1001582009668 conserved gate region; other site 1001582009669 putative PBP binding loops; other site 1001582009670 ABC-ATPase subunit interface; other site 1001582009671 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1001582009672 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1001582009673 Walker A/P-loop; other site 1001582009674 ATP binding site [chemical binding]; other site 1001582009675 Q-loop/lid; other site 1001582009676 ABC transporter signature motif; other site 1001582009677 Walker B; other site 1001582009678 D-loop; other site 1001582009679 H-loop/switch region; other site 1001582009680 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1001582009681 Predicted transcriptional regulators [Transcription]; Region: COG1510 1001582009682 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582009683 putative DNA binding site [nucleotide binding]; other site 1001582009684 putative Zn2+ binding site [ion binding]; other site 1001582009685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582009686 dimer interface [polypeptide binding]; other site 1001582009687 conserved gate region; other site 1001582009688 putative PBP binding loops; other site 1001582009689 ABC-ATPase subunit interface; other site 1001582009690 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1001582009691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1001582009692 dimer interface [polypeptide binding]; other site 1001582009693 conserved gate region; other site 1001582009694 putative PBP binding loops; other site 1001582009695 ABC-ATPase subunit interface; other site 1001582009696 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1001582009697 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1001582009698 Walker A/P-loop; other site 1001582009699 ATP binding site [chemical binding]; other site 1001582009700 Q-loop/lid; other site 1001582009701 ABC transporter signature motif; other site 1001582009702 Walker B; other site 1001582009703 D-loop; other site 1001582009704 H-loop/switch region; other site 1001582009705 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1001582009706 Predicted transcriptional regulators [Transcription]; Region: COG1510 1001582009707 MarR family; Region: MarR_2; pfam12802 1001582009708 membrane protein, MarC family; Region: TIGR00427 1001582009709 Predicted membrane protein [Function unknown]; Region: COG4640 1001582009710 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1001582009711 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582009712 Coenzyme A binding pocket [chemical binding]; other site 1001582009713 H+ Antiporter protein; Region: 2A0121; TIGR00900 1001582009714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582009715 putative substrate translocation pore; other site 1001582009716 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1001582009717 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1001582009718 WbqC-like protein family; Region: WbqC; pfam08889 1001582009719 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1001582009720 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1001582009721 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1001582009722 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1001582009723 catalytic residue [active] 1001582009724 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1001582009725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001582009726 NAD(P) binding site [chemical binding]; other site 1001582009727 active site 1001582009728 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1001582009729 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1001582009730 inhibitor-cofactor binding pocket; inhibition site 1001582009731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582009732 catalytic residue [active] 1001582009733 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1001582009734 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1001582009735 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1001582009736 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1001582009737 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1001582009738 putative integrin binding motif; other site 1001582009739 PA/protease domain interface [polypeptide binding]; other site 1001582009740 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1001582009741 Peptidase family M28; Region: Peptidase_M28; pfam04389 1001582009742 metal binding site [ion binding]; metal-binding site 1001582009743 enolase; Provisional; Region: eno; PRK00077 1001582009744 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1001582009745 dimer interface [polypeptide binding]; other site 1001582009746 metal binding site [ion binding]; metal-binding site 1001582009747 substrate binding pocket [chemical binding]; other site 1001582009748 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1001582009749 phosphoglyceromutase; Provisional; Region: PRK05434 1001582009750 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1001582009751 triosephosphate isomerase; Provisional; Region: PRK14565 1001582009752 substrate binding site [chemical binding]; other site 1001582009753 dimer interface [polypeptide binding]; other site 1001582009754 catalytic triad [active] 1001582009755 Phosphoglycerate kinase; Region: PGK; pfam00162 1001582009756 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1001582009757 substrate binding site [chemical binding]; other site 1001582009758 hinge regions; other site 1001582009759 ADP binding site [chemical binding]; other site 1001582009760 catalytic site [active] 1001582009761 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1001582009762 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1001582009763 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1001582009764 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1001582009765 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1001582009766 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1001582009767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582009768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582009769 DNA-binding site [nucleotide binding]; DNA binding site 1001582009770 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001582009771 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1001582009772 putative dimerization interface [polypeptide binding]; other site 1001582009773 putative ligand binding site [chemical binding]; other site 1001582009774 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1001582009775 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1001582009776 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1001582009777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001582009778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001582009779 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1001582009780 dimerization interface [polypeptide binding]; other site 1001582009781 EamA-like transporter family; Region: EamA; pfam00892 1001582009782 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1001582009783 EamA-like transporter family; Region: EamA; pfam00892 1001582009784 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1001582009785 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1001582009786 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1001582009787 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1001582009788 putative active site [active] 1001582009789 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1001582009790 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1001582009791 N- and C-terminal domain interface [polypeptide binding]; other site 1001582009792 active site 1001582009793 catalytic site [active] 1001582009794 metal binding site [ion binding]; metal-binding site 1001582009795 carbohydrate binding site [chemical binding]; other site 1001582009796 ATP binding site [chemical binding]; other site 1001582009797 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1001582009798 GntP family permease; Region: GntP_permease; pfam02447 1001582009799 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1001582009800 iron-sulfur cluster-binding protein; Region: TIGR00273 1001582009801 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1001582009802 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1001582009803 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1001582009804 Cysteine-rich domain; Region: CCG; pfam02754 1001582009805 Cysteine-rich domain; Region: CCG; pfam02754 1001582009806 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1001582009807 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582009808 DNA-binding site [nucleotide binding]; DNA binding site 1001582009809 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1001582009810 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1001582009811 L-lactate permease; Region: Lactate_perm; pfam02652 1001582009812 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1001582009813 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1001582009814 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1001582009815 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1001582009816 YvfG protein; Region: YvfG; pfam09628 1001582009817 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1001582009818 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1001582009819 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1001582009820 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1001582009821 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1001582009822 inhibitor-cofactor binding pocket; inhibition site 1001582009823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582009824 catalytic residue [active] 1001582009825 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1001582009826 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1001582009827 putative trimer interface [polypeptide binding]; other site 1001582009828 putative CoA binding site [chemical binding]; other site 1001582009829 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1001582009830 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1001582009831 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1001582009832 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1001582009833 active site 1001582009834 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1001582009835 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1001582009836 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1001582009837 active site 1001582009838 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001582009839 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1001582009840 putative ADP-binding pocket [chemical binding]; other site 1001582009841 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1001582009842 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1001582009843 active site 1001582009844 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1001582009845 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001582009846 putative ADP-binding pocket [chemical binding]; other site 1001582009847 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1001582009848 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1001582009849 NAD(P) binding site [chemical binding]; other site 1001582009850 homodimer interface [polypeptide binding]; other site 1001582009851 substrate binding site [chemical binding]; other site 1001582009852 active site 1001582009853 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1001582009854 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1001582009855 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1001582009856 Chain length determinant protein; Region: Wzz; cl15801 1001582009857 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1001582009858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1001582009859 non-specific DNA binding site [nucleotide binding]; other site 1001582009860 salt bridge; other site 1001582009861 sequence-specific DNA binding site [nucleotide binding]; other site 1001582009862 Anti-repressor SinI; Region: SinI; pfam08671 1001582009863 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1001582009864 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1001582009865 substrate binding pocket [chemical binding]; other site 1001582009866 catalytic triad [active] 1001582009867 RibD C-terminal domain; Region: RibD_C; cl17279 1001582009868 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1001582009869 hypothetical protein; Provisional; Region: PRK07236 1001582009870 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1001582009871 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1001582009872 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1001582009873 Predicted membrane protein [Function unknown]; Region: COG2364 1001582009874 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001582009875 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1001582009876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582009877 Coenzyme A binding pocket [chemical binding]; other site 1001582009878 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1001582009879 hypothetical protein; Provisional; Region: PRK00872 1001582009880 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1001582009881 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1001582009882 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1001582009883 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 1001582009884 nucleophilic elbow; other site 1001582009885 catalytic triad; other site 1001582009886 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1001582009887 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1001582009888 substrate binding [chemical binding]; other site 1001582009889 active site 1001582009890 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1001582009891 galactoside permease; Reviewed; Region: lacY; PRK09528 1001582009892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582009893 putative substrate translocation pore; other site 1001582009894 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001582009895 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001582009896 DNA binding site [nucleotide binding] 1001582009897 domain linker motif; other site 1001582009898 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1001582009899 dimerization interface [polypeptide binding]; other site 1001582009900 ligand binding site [chemical binding]; other site 1001582009901 sodium binding site [ion binding]; other site 1001582009902 Clp protease; Region: CLP_protease; pfam00574 1001582009903 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1001582009904 oligomer interface [polypeptide binding]; other site 1001582009905 active site residues [active] 1001582009906 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001582009907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001582009908 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1001582009909 dimerization interface [polypeptide binding]; other site 1001582009910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1001582009911 benzoate transport; Region: 2A0115; TIGR00895 1001582009912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582009913 putative substrate translocation pore; other site 1001582009914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582009915 TIGR00730 family protein; Region: TIGR00730 1001582009916 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1001582009917 metal binding site [ion binding]; metal-binding site 1001582009918 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1001582009919 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1001582009920 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1001582009921 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1001582009922 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1001582009923 active site clefts [active] 1001582009924 zinc binding site [ion binding]; other site 1001582009925 dimer interface [polypeptide binding]; other site 1001582009926 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1001582009927 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1001582009928 dimerization interface [polypeptide binding]; other site 1001582009929 ligand binding site [chemical binding]; other site 1001582009930 NADP binding site [chemical binding]; other site 1001582009931 catalytic site [active] 1001582009932 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 1001582009933 active site 1001582009934 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1001582009935 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1001582009936 dimerization domain swap beta strand [polypeptide binding]; other site 1001582009937 regulatory protein interface [polypeptide binding]; other site 1001582009938 active site 1001582009939 regulatory phosphorylation site [posttranslational modification]; other site 1001582009940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1001582009941 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1001582009942 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1001582009943 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1001582009944 phosphate binding site [ion binding]; other site 1001582009945 putative substrate binding pocket [chemical binding]; other site 1001582009946 dimer interface [polypeptide binding]; other site 1001582009947 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1001582009948 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1001582009949 putative active site [active] 1001582009950 nucleotide binding site [chemical binding]; other site 1001582009951 nudix motif; other site 1001582009952 putative metal binding site [ion binding]; other site 1001582009953 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1001582009954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001582009955 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001582009956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1001582009957 GDP/GTP exchange factor Sec2p; Region: Sec2p; pfam06428 1001582009958 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1001582009959 NlpC/P60 family; Region: NLPC_P60; pfam00877 1001582009960 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582009961 binding surface 1001582009962 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1001582009963 TPR motif; other site 1001582009964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582009965 TPR motif; other site 1001582009966 binding surface 1001582009967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582009968 dimer interface [polypeptide binding]; other site 1001582009969 phosphorylation site [posttranslational modification] 1001582009970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582009971 ATP binding site [chemical binding]; other site 1001582009972 Mg2+ binding site [ion binding]; other site 1001582009973 G-X-G motif; other site 1001582009974 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001582009975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582009976 active site 1001582009977 phosphorylation site [posttranslational modification] 1001582009978 intermolecular recognition site; other site 1001582009979 dimerization interface [polypeptide binding]; other site 1001582009980 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001582009981 DNA binding site [nucleotide binding] 1001582009982 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1001582009983 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001582009984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582009985 Walker A/P-loop; other site 1001582009986 ATP binding site [chemical binding]; other site 1001582009987 Q-loop/lid; other site 1001582009988 ABC transporter signature motif; other site 1001582009989 Walker B; other site 1001582009990 D-loop; other site 1001582009991 H-loop/switch region; other site 1001582009992 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1001582009993 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1001582009994 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1001582009995 metal binding site [ion binding]; metal-binding site 1001582009996 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1001582009997 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1001582009998 substrate binding site [chemical binding]; other site 1001582009999 glutamase interaction surface [polypeptide binding]; other site 1001582010000 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1001582010001 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1001582010002 catalytic residues [active] 1001582010003 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1001582010004 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1001582010005 putative active site [active] 1001582010006 oxyanion strand; other site 1001582010007 catalytic triad [active] 1001582010008 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1001582010009 putative active site pocket [active] 1001582010010 4-fold oligomerization interface [polypeptide binding]; other site 1001582010011 metal binding residues [ion binding]; metal-binding site 1001582010012 3-fold/trimer interface [polypeptide binding]; other site 1001582010013 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1001582010014 histidinol dehydrogenase; Region: hisD; TIGR00069 1001582010015 NAD binding site [chemical binding]; other site 1001582010016 dimerization interface [polypeptide binding]; other site 1001582010017 product binding site; other site 1001582010018 substrate binding site [chemical binding]; other site 1001582010019 zinc binding site [ion binding]; other site 1001582010020 catalytic residues [active] 1001582010021 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1001582010022 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1001582010023 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1001582010024 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1001582010025 dimer interface [polypeptide binding]; other site 1001582010026 motif 1; other site 1001582010027 active site 1001582010028 motif 2; other site 1001582010029 motif 3; other site 1001582010030 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1001582010031 putative active site [active] 1001582010032 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1001582010033 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1001582010034 trimer interface [polypeptide binding]; other site 1001582010035 active site 1001582010036 substrate binding site [chemical binding]; other site 1001582010037 CoA binding site [chemical binding]; other site 1001582010038 pyrophosphatase PpaX; Provisional; Region: PRK13288 1001582010039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1001582010040 motif I; other site 1001582010041 active site 1001582010042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582010043 motif II; other site 1001582010044 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1001582010045 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1001582010046 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1001582010047 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1001582010048 Hpr binding site; other site 1001582010049 active site 1001582010050 homohexamer subunit interaction site [polypeptide binding]; other site 1001582010051 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1001582010052 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1001582010053 active site 1001582010054 dimer interface [polypeptide binding]; other site 1001582010055 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1001582010056 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1001582010057 active site 1001582010058 trimer interface [polypeptide binding]; other site 1001582010059 allosteric site; other site 1001582010060 active site lid [active] 1001582010061 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1001582010062 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1001582010063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582010064 DNA-binding site [nucleotide binding]; DNA binding site 1001582010065 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1001582010066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582010067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582010068 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1001582010069 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1001582010070 putative active site [active] 1001582010071 putative metal binding site [ion binding]; other site 1001582010072 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1001582010073 Predicted membrane protein [Function unknown]; Region: COG1950 1001582010074 PspC domain; Region: PspC; pfam04024 1001582010075 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1001582010076 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1001582010077 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1001582010078 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1001582010079 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1001582010080 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1001582010081 excinuclease ABC subunit B; Provisional; Region: PRK05298 1001582010082 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001582010083 ATP binding site [chemical binding]; other site 1001582010084 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001582010085 nucleotide binding region [chemical binding]; other site 1001582010086 ATP-binding site [chemical binding]; other site 1001582010087 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1001582010088 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 1001582010089 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1001582010090 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1001582010091 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1001582010092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582010093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582010094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582010095 putative substrate translocation pore; other site 1001582010096 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1001582010097 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1001582010098 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1001582010099 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1001582010100 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1001582010101 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1001582010102 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1001582010103 C-terminal peptidase (prc); Region: prc; TIGR00225 1001582010104 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1001582010105 protein binding site [polypeptide binding]; other site 1001582010106 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1001582010107 Catalytic dyad [active] 1001582010108 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1001582010109 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 1001582010110 Right handed beta helix region; Region: Beta_helix; pfam13229 1001582010111 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1001582010112 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1001582010113 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1001582010114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582010115 Walker A/P-loop; other site 1001582010116 ATP binding site [chemical binding]; other site 1001582010117 Q-loop/lid; other site 1001582010118 ABC transporter signature motif; other site 1001582010119 Walker B; other site 1001582010120 D-loop; other site 1001582010121 H-loop/switch region; other site 1001582010122 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1001582010123 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1001582010124 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1001582010125 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001582010126 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001582010127 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1001582010128 peptide chain release factor 2; Provisional; Region: PRK06746 1001582010129 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1001582010130 RF-1 domain; Region: RF-1; pfam00472 1001582010131 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1001582010132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1001582010133 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1001582010134 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1001582010135 nucleotide binding region [chemical binding]; other site 1001582010136 ATP-binding site [chemical binding]; other site 1001582010137 SEC-C motif; Region: SEC-C; pfam02810 1001582010138 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1001582010139 30S subunit binding site; other site 1001582010140 Flagellar protein FliT; Region: FliT; pfam05400 1001582010141 flagellar protein FliS; Validated; Region: fliS; PRK05685 1001582010142 flagellar capping protein; Validated; Region: fliD; PRK07737 1001582010143 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1001582010144 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1001582010145 flagellin; Provisional; Region: PRK12804 1001582010146 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1001582010147 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1001582010148 carbon storage regulator; Provisional; Region: PRK01712 1001582010149 flagellar assembly protein FliW; Provisional; Region: PRK13285 1001582010150 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1001582010151 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1001582010152 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1001582010153 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1001582010154 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1001582010155 FlgN protein; Region: FlgN; pfam05130 1001582010156 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1001582010157 flagellar operon protein TIGR03826; Region: YvyF 1001582010158 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001582010159 active site 1001582010160 Late competence development protein ComFB; Region: ComFB; pfam10719 1001582010161 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1001582010162 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001582010163 ATP binding site [chemical binding]; other site 1001582010164 putative Mg++ binding site [ion binding]; other site 1001582010165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001582010166 nucleotide binding region [chemical binding]; other site 1001582010167 ATP-binding site [chemical binding]; other site 1001582010168 EDD domain protein, DegV family; Region: DegV; TIGR00762 1001582010169 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1001582010170 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1001582010171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582010172 active site 1001582010173 phosphorylation site [posttranslational modification] 1001582010174 intermolecular recognition site; other site 1001582010175 dimerization interface [polypeptide binding]; other site 1001582010176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1001582010177 DNA binding residues [nucleotide binding] 1001582010178 dimerization interface [polypeptide binding]; other site 1001582010179 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1001582010180 Histidine kinase; Region: HisKA_3; pfam07730 1001582010181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582010182 ATP binding site [chemical binding]; other site 1001582010183 Mg2+ binding site [ion binding]; other site 1001582010184 G-X-G motif; other site 1001582010185 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1001582010186 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1001582010187 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1001582010188 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1001582010189 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1001582010190 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1001582010191 Mg++ binding site [ion binding]; other site 1001582010192 putative catalytic motif [active] 1001582010193 substrate binding site [chemical binding]; other site 1001582010194 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1001582010195 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001582010196 putative homodimer interface [polypeptide binding]; other site 1001582010197 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1001582010198 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1001582010199 active site 1001582010200 Chain length determinant protein; Region: Wzz; cl15801 1001582010201 O-Antigen ligase; Region: Wzy_C; pfam04932 1001582010202 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1001582010203 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1001582010204 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1001582010205 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1001582010206 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1001582010207 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001582010208 colanic acid exporter; Provisional; Region: PRK10459 1001582010209 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1001582010210 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1001582010211 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1001582010212 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1001582010213 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1001582010214 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1001582010215 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1001582010216 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1001582010217 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1001582010218 active site 1001582010219 metal binding site [ion binding]; metal-binding site 1001582010220 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1001582010221 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1001582010222 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1001582010223 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1001582010224 Stage II sporulation protein; Region: SpoIID; pfam08486 1001582010225 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1001582010226 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 1001582010227 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 1001582010228 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1001582010229 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1001582010230 active site 1001582010231 homodimer interface [polypeptide binding]; other site 1001582010232 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1001582010233 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1001582010234 active site 1001582010235 tetramer interface; other site 1001582010236 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1001582010237 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1001582010238 Walker A/P-loop; other site 1001582010239 ATP binding site [chemical binding]; other site 1001582010240 Q-loop/lid; other site 1001582010241 ABC transporter signature motif; other site 1001582010242 Walker B; other site 1001582010243 D-loop; other site 1001582010244 H-loop/switch region; other site 1001582010245 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1001582010246 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1001582010247 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1001582010248 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1001582010249 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1001582010250 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1001582010251 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001582010252 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1001582010253 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1001582010254 active site 1001582010255 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1001582010256 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1001582010257 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1001582010258 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1001582010259 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1001582010260 Bacterial SH3 domain; Region: SH3_3; pfam08239 1001582010261 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1001582010262 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1001582010263 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1001582010264 Spore germination protein; Region: Spore_permease; pfam03845 1001582010265 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1001582010266 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1001582010267 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1001582010268 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1001582010269 Probable Catalytic site; other site 1001582010270 metal-binding site 1001582010271 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1001582010272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582010273 S-adenosylmethionine binding site [chemical binding]; other site 1001582010274 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1001582010275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582010276 putative substrate translocation pore; other site 1001582010277 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1001582010278 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582010279 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1001582010280 active site 1001582010281 motif I; other site 1001582010282 motif II; other site 1001582010283 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1001582010284 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1001582010285 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1001582010286 NlpC/P60 family; Region: NLPC_P60; pfam00877 1001582010287 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1001582010288 NlpC/P60 family; Region: NLPC_P60; pfam00877 1001582010289 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1001582010290 NlpC/P60 family; Region: NLPC_P60; pfam00877 1001582010291 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1001582010292 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1001582010293 putative active site [active] 1001582010294 putative metal binding site [ion binding]; other site 1001582010295 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 1001582010296 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1001582010297 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1001582010298 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1001582010299 Spore germination protein; Region: Spore_permease; cl17796 1001582010300 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1001582010301 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1001582010302 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001582010303 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001582010304 DNA binding site [nucleotide binding] 1001582010305 domain linker motif; other site 1001582010306 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1001582010307 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1001582010308 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1001582010309 substrate binding site [chemical binding]; other site 1001582010310 dimer interface [polypeptide binding]; other site 1001582010311 ATP binding site [chemical binding]; other site 1001582010312 D-ribose pyranase; Provisional; Region: PRK11797 1001582010313 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1001582010314 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582010315 Walker A/P-loop; other site 1001582010316 ATP binding site [chemical binding]; other site 1001582010317 Q-loop/lid; other site 1001582010318 ABC transporter signature motif; other site 1001582010319 Walker B; other site 1001582010320 D-loop; other site 1001582010321 H-loop/switch region; other site 1001582010322 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1001582010323 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1001582010324 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1001582010325 TM-ABC transporter signature motif; other site 1001582010326 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1001582010327 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1001582010328 ligand binding site [chemical binding]; other site 1001582010329 dimerization interface [polypeptide binding]; other site 1001582010330 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1001582010331 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1001582010332 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1001582010333 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1001582010334 acetolactate synthase; Reviewed; Region: PRK08617 1001582010335 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1001582010336 PYR/PP interface [polypeptide binding]; other site 1001582010337 dimer interface [polypeptide binding]; other site 1001582010338 TPP binding site [chemical binding]; other site 1001582010339 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1001582010340 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1001582010341 TPP-binding site [chemical binding]; other site 1001582010342 dimer interface [polypeptide binding]; other site 1001582010343 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1001582010344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001582010345 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1001582010346 putative dimerization interface [polypeptide binding]; other site 1001582010347 putative substrate binding pocket [chemical binding]; other site 1001582010348 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1001582010349 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1001582010350 transmembrane helices; other site 1001582010351 CotH protein; Region: CotH; pfam08757 1001582010352 DNA translocase FtsK; Provisional; Region: PRK10263 1001582010353 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1001582010354 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1001582010355 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1001582010356 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1001582010357 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1001582010358 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582010359 putative DNA binding site [nucleotide binding]; other site 1001582010360 putative Zn2+ binding site [ion binding]; other site 1001582010361 AsnC family; Region: AsnC_trans_reg; pfam01037 1001582010362 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1001582010363 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1001582010364 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1001582010365 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 1001582010366 LXG domain of WXG superfamily; Region: LXG; pfam04740 1001582010367 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1001582010368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1001582010369 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1001582010370 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1001582010371 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1001582010372 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1001582010373 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1001582010374 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1001582010375 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1001582010376 Nucleotide binding site [chemical binding]; other site 1001582010377 DTAP/Switch II; other site 1001582010378 Switch I; other site 1001582010379 Chain length determinant protein; Region: Wzz; cl15801 1001582010380 SWIM zinc finger; Region: SWIM; pfam04434 1001582010381 SNF2 Helicase protein; Region: DUF3670; pfam12419 1001582010382 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1001582010383 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1001582010384 ATP binding site [chemical binding]; other site 1001582010385 putative Mg++ binding site [ion binding]; other site 1001582010386 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1001582010387 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001582010388 nucleotide binding region [chemical binding]; other site 1001582010389 ATP-binding site [chemical binding]; other site 1001582010390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582010391 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1001582010392 active site 1001582010393 motif I; other site 1001582010394 motif II; other site 1001582010395 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582010396 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1001582010397 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1001582010398 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1001582010399 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1001582010400 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1001582010401 dimer interface [polypeptide binding]; other site 1001582010402 ssDNA binding site [nucleotide binding]; other site 1001582010403 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1001582010404 YwpF-like protein; Region: YwpF; pfam14183 1001582010405 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1001582010406 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1001582010407 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1001582010408 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582010409 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582010410 binding surface 1001582010411 TPR motif; other site 1001582010412 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582010413 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1001582010414 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1001582010415 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1001582010416 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1001582010417 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1001582010418 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1001582010419 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1001582010420 MreB and similar proteins; Region: MreB_like; cd10225 1001582010421 nucleotide binding site [chemical binding]; other site 1001582010422 Mg binding site [ion binding]; other site 1001582010423 putative protofilament interaction site [polypeptide binding]; other site 1001582010424 RodZ interaction site [polypeptide binding]; other site 1001582010425 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1001582010426 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582010427 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582010428 putative Zn2+ binding site [ion binding]; other site 1001582010429 putative DNA binding site [nucleotide binding]; other site 1001582010430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582010431 putative substrate translocation pore; other site 1001582010432 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582010433 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1001582010434 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1001582010435 Na binding site [ion binding]; other site 1001582010436 putative substrate binding site [chemical binding]; other site 1001582010437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582010438 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582010439 putative substrate translocation pore; other site 1001582010440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582010441 Isochorismatase family; Region: Isochorismatase; pfam00857 1001582010442 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1001582010443 catalytic triad [active] 1001582010444 conserved cis-peptide bond; other site 1001582010445 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1001582010446 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1001582010447 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1001582010448 cell division protein FtsW; Region: ftsW; TIGR02614 1001582010449 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1001582010450 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1001582010451 active site 1001582010452 VanZ like family; Region: VanZ; pfam04892 1001582010453 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1001582010454 Peptidase family M23; Region: Peptidase_M23; pfam01551 1001582010455 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1001582010456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582010457 Coenzyme A binding pocket [chemical binding]; other site 1001582010458 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1001582010459 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1001582010460 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1001582010461 putative active site [active] 1001582010462 catalytic site [active] 1001582010463 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1001582010464 putative active site [active] 1001582010465 catalytic site [active] 1001582010466 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1001582010467 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1001582010468 NAD binding site [chemical binding]; other site 1001582010469 substrate binding site [chemical binding]; other site 1001582010470 putative active site [active] 1001582010471 Predicted transcriptional regulator [Transcription]; Region: COG1959 1001582010472 Transcriptional regulator; Region: Rrf2; pfam02082 1001582010473 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1001582010474 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1001582010475 subunit interactions [polypeptide binding]; other site 1001582010476 active site 1001582010477 flap region; other site 1001582010478 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1001582010479 gamma-beta subunit interface [polypeptide binding]; other site 1001582010480 alpha-beta subunit interface [polypeptide binding]; other site 1001582010481 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1001582010482 alpha-gamma subunit interface [polypeptide binding]; other site 1001582010483 beta-gamma subunit interface [polypeptide binding]; other site 1001582010484 CsbD-like; Region: CsbD; pfam05532 1001582010485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1001582010486 TPR motif; other site 1001582010487 binding surface 1001582010488 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582010489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582010490 binding surface 1001582010491 TPR motif; other site 1001582010492 TPR repeat; Region: TPR_11; pfam13414 1001582010493 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1001582010494 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1001582010495 FeS/SAM binding site; other site 1001582010496 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1001582010497 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1001582010498 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1001582010499 metal ion-dependent adhesion site (MIDAS); other site 1001582010500 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1001582010501 metal ion-dependent adhesion site (MIDAS); other site 1001582010502 Stage II sporulation protein; Region: SpoIID; pfam08486 1001582010503 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1001582010504 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1001582010505 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1001582010506 hinge; other site 1001582010507 active site 1001582010508 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1001582010509 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1001582010510 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1001582010511 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1001582010512 gamma subunit interface [polypeptide binding]; other site 1001582010513 epsilon subunit interface [polypeptide binding]; other site 1001582010514 LBP interface [polypeptide binding]; other site 1001582010515 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1001582010516 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1001582010517 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1001582010518 alpha subunit interaction interface [polypeptide binding]; other site 1001582010519 Walker A motif; other site 1001582010520 ATP binding site [chemical binding]; other site 1001582010521 Walker B motif; other site 1001582010522 inhibitor binding site; inhibition site 1001582010523 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1001582010524 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1001582010525 core domain interface [polypeptide binding]; other site 1001582010526 delta subunit interface [polypeptide binding]; other site 1001582010527 epsilon subunit interface [polypeptide binding]; other site 1001582010528 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1001582010529 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1001582010530 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1001582010531 beta subunit interaction interface [polypeptide binding]; other site 1001582010532 Walker A motif; other site 1001582010533 ATP binding site [chemical binding]; other site 1001582010534 Walker B motif; other site 1001582010535 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1001582010536 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 1001582010537 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1001582010538 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1001582010539 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1001582010540 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1001582010541 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1001582010542 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1001582010543 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1001582010544 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1001582010545 active site 1001582010546 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1001582010547 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1001582010548 dimer interface [polypeptide binding]; other site 1001582010549 active site 1001582010550 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1001582010551 folate binding site [chemical binding]; other site 1001582010552 hypothetical protein; Provisional; Region: PRK13690 1001582010553 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1001582010554 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1001582010555 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1001582010556 active site 1001582010557 Predicted membrane protein [Function unknown]; Region: COG1971 1001582010558 Domain of unknown function DUF; Region: DUF204; pfam02659 1001582010559 Domain of unknown function DUF; Region: DUF204; pfam02659 1001582010560 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1001582010561 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1001582010562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1001582010563 stage II sporulation protein R; Region: spore_II_R; TIGR02837 1001582010564 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1001582010565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582010566 S-adenosylmethionine binding site [chemical binding]; other site 1001582010567 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1001582010568 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1001582010569 RF-1 domain; Region: RF-1; pfam00472 1001582010570 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1001582010571 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1001582010572 putative metal binding site [ion binding]; other site 1001582010573 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1001582010574 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1001582010575 DNA binding residues [nucleotide binding] 1001582010576 Trypanosomal VSG domain; Region: VSG_B; cl11958 1001582010577 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1001582010578 malate dehydrogenase; Provisional; Region: PRK13529 1001582010579 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1001582010580 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1001582010581 NAD(P) binding site [chemical binding]; other site 1001582010582 thymidine kinase; Provisional; Region: PRK04296 1001582010583 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1001582010584 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1001582010585 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1001582010586 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1001582010587 RNA binding site [nucleotide binding]; other site 1001582010588 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1001582010589 multimer interface [polypeptide binding]; other site 1001582010590 Walker A motif; other site 1001582010591 ATP binding site [chemical binding]; other site 1001582010592 Walker B motif; other site 1001582010593 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1001582010594 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1001582010595 putative active site [active] 1001582010596 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1001582010597 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1001582010598 hinge; other site 1001582010599 active site 1001582010600 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1001582010601 active site 1001582010602 intersubunit interactions; other site 1001582010603 catalytic residue [active] 1001582010604 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1001582010605 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1001582010606 intersubunit interface [polypeptide binding]; other site 1001582010607 active site 1001582010608 zinc binding site [ion binding]; other site 1001582010609 Na+ binding site [ion binding]; other site 1001582010610 Response regulator receiver domain; Region: Response_reg; pfam00072 1001582010611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582010612 active site 1001582010613 phosphorylation site [posttranslational modification] 1001582010614 intermolecular recognition site; other site 1001582010615 dimerization interface [polypeptide binding]; other site 1001582010616 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1001582010617 CTP synthetase; Validated; Region: pyrG; PRK05380 1001582010618 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1001582010619 Catalytic site [active] 1001582010620 active site 1001582010621 UTP binding site [chemical binding]; other site 1001582010622 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1001582010623 active site 1001582010624 putative oxyanion hole; other site 1001582010625 catalytic triad [active] 1001582010626 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1001582010627 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1001582010628 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1001582010629 Cysteine-rich domain; Region: CCG; pfam02754 1001582010630 Cysteine-rich domain; Region: CCG; pfam02754 1001582010631 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1001582010632 PLD-like domain; Region: PLDc_2; pfam13091 1001582010633 putative active site [active] 1001582010634 catalytic site [active] 1001582010635 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1001582010636 PLD-like domain; Region: PLDc_2; pfam13091 1001582010637 putative active site [active] 1001582010638 catalytic site [active] 1001582010639 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 1001582010640 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1001582010641 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001582010642 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1001582010643 Walker A/P-loop; other site 1001582010644 ATP binding site [chemical binding]; other site 1001582010645 Q-loop/lid; other site 1001582010646 ABC transporter signature motif; other site 1001582010647 Walker B; other site 1001582010648 D-loop; other site 1001582010649 H-loop/switch region; other site 1001582010650 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1001582010651 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1001582010652 putative active site [active] 1001582010653 catalytic site [active] 1001582010654 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1001582010655 putative active site [active] 1001582010656 catalytic site [active] 1001582010657 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1001582010658 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1001582010659 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1001582010660 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1001582010661 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1001582010662 [4Fe-4S] binding site [ion binding]; other site 1001582010663 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1001582010664 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1001582010665 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1001582010666 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1001582010667 molybdopterin cofactor binding site; other site 1001582010668 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1001582010669 ligand binding site [chemical binding]; other site 1001582010670 flexible hinge region; other site 1001582010671 YwiC-like protein; Region: YwiC; pfam14256 1001582010672 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1001582010673 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1001582010674 ligand binding site [chemical binding]; other site 1001582010675 flexible hinge region; other site 1001582010676 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1001582010677 putative switch regulator; other site 1001582010678 non-specific DNA interactions [nucleotide binding]; other site 1001582010679 DNA binding site [nucleotide binding] 1001582010680 sequence specific DNA binding site [nucleotide binding]; other site 1001582010681 putative cAMP binding site [chemical binding]; other site 1001582010682 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1001582010683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582010684 putative substrate translocation pore; other site 1001582010685 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1001582010686 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1001582010687 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1001582010688 active site 1001582010689 HIGH motif; other site 1001582010690 KMSK motif region; other site 1001582010691 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1001582010692 tRNA binding surface [nucleotide binding]; other site 1001582010693 anticodon binding site; other site 1001582010694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 1001582010695 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1001582010696 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1001582010697 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1001582010698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1001582010699 binding surface 1001582010700 TPR motif; other site 1001582010701 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582010702 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1001582010703 agmatinase; Region: agmatinase; TIGR01230 1001582010704 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1001582010705 putative active site [active] 1001582010706 Mn binding site [ion binding]; other site 1001582010707 spermidine synthase; Provisional; Region: PRK00811 1001582010708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1001582010709 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1001582010710 Transglycosylase; Region: Transgly; pfam00912 1001582010711 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1001582010712 YwhD family; Region: YwhD; pfam08741 1001582010713 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1001582010714 Peptidase family M50; Region: Peptidase_M50; pfam02163 1001582010715 active site 1001582010716 putative substrate binding region [chemical binding]; other site 1001582010717 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1001582010718 active site 1 [active] 1001582010719 dimer interface [polypeptide binding]; other site 1001582010720 hexamer interface [polypeptide binding]; other site 1001582010721 active site 2 [active] 1001582010722 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582010723 dimerization interface [polypeptide binding]; other site 1001582010724 putative DNA binding site [nucleotide binding]; other site 1001582010725 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582010726 putative Zn2+ binding site [ion binding]; other site 1001582010727 amino acid transporter; Region: 2A0306; TIGR00909 1001582010728 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1001582010729 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1001582010730 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1001582010731 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1001582010732 Zn2+ binding site [ion binding]; other site 1001582010733 Mg2+ binding site [ion binding]; other site 1001582010734 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1001582010735 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1001582010736 Predicted transcriptional regulators [Transcription]; Region: COG1695 1001582010737 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1001582010738 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1001582010739 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1001582010740 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1001582010741 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1001582010742 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001582010743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001582010744 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1001582010745 putative dimerization interface [polypeptide binding]; other site 1001582010746 Predicted membrane protein [Function unknown]; Region: COG2855 1001582010747 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1001582010748 putative heme peroxidase; Provisional; Region: PRK12276 1001582010749 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1001582010750 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1001582010751 putative NAD(P) binding site [chemical binding]; other site 1001582010752 putative active site [active] 1001582010753 transaminase; Reviewed; Region: PRK08068 1001582010754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1001582010755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582010756 homodimer interface [polypeptide binding]; other site 1001582010757 catalytic residue [active] 1001582010758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582010759 H+ Antiporter protein; Region: 2A0121; TIGR00900 1001582010760 putative substrate translocation pore; other site 1001582010761 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1001582010762 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1001582010763 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1001582010764 classical (c) SDRs; Region: SDR_c; cd05233 1001582010765 NAD(P) binding site [chemical binding]; other site 1001582010766 active site 1001582010767 Cupin domain; Region: Cupin_2; pfam07883 1001582010768 Cupin domain; Region: Cupin_2; pfam07883 1001582010769 Prephenate dehydratase; Region: PDT; pfam00800 1001582010770 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1001582010771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582010772 putative substrate translocation pore; other site 1001582010773 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1001582010774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582010775 putative substrate translocation pore; other site 1001582010776 S-methylmethionine transporter; Provisional; Region: PRK11387 1001582010777 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1001582010778 putative metal binding site [ion binding]; other site 1001582010779 putative dimer interface [polypeptide binding]; other site 1001582010780 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1001582010781 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1001582010782 Glutamate binding site [chemical binding]; other site 1001582010783 homodimer interface [polypeptide binding]; other site 1001582010784 NAD binding site [chemical binding]; other site 1001582010785 catalytic residues [active] 1001582010786 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1001582010787 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1001582010788 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1001582010789 NAD(P) binding site [chemical binding]; other site 1001582010790 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1001582010791 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1001582010792 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1001582010793 NADP binding site [chemical binding]; other site 1001582010794 active site 1001582010795 putative substrate binding site [chemical binding]; other site 1001582010796 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1001582010797 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1001582010798 NAD binding site [chemical binding]; other site 1001582010799 substrate binding site [chemical binding]; other site 1001582010800 homodimer interface [polypeptide binding]; other site 1001582010801 active site 1001582010802 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1001582010803 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1001582010804 substrate binding site; other site 1001582010805 tetramer interface; other site 1001582010806 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1001582010807 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1001582010808 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1001582010809 ligand binding site; other site 1001582010810 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1001582010811 NeuB family; Region: NeuB; pfam03102 1001582010812 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1001582010813 NeuB binding interface [polypeptide binding]; other site 1001582010814 putative substrate binding site [chemical binding]; other site 1001582010815 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1001582010816 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1001582010817 Coenzyme A binding pocket [chemical binding]; other site 1001582010818 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1001582010819 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1001582010820 inhibitor-cofactor binding pocket; inhibition site 1001582010821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582010822 catalytic residue [active] 1001582010823 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1001582010824 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1001582010825 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1001582010826 active site 1001582010827 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1001582010828 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1001582010829 Permease family; Region: Xan_ur_permease; pfam00860 1001582010830 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1001582010831 ligand binding site [chemical binding]; other site 1001582010832 active site 1001582010833 UGI interface [polypeptide binding]; other site 1001582010834 catalytic site [active] 1001582010835 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1001582010836 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1001582010837 active site 1001582010838 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1001582010839 dimer interface [polypeptide binding]; other site 1001582010840 substrate binding site [chemical binding]; other site 1001582010841 ATP binding site [chemical binding]; other site 1001582010842 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1001582010843 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1001582010844 substrate binding [chemical binding]; other site 1001582010845 active site 1001582010846 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1001582010847 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1001582010848 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1001582010849 active site turn [active] 1001582010850 phosphorylation site [posttranslational modification] 1001582010851 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1001582010852 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1001582010853 CAT RNA binding domain; Region: CAT_RBD; smart01061 1001582010854 PRD domain; Region: PRD; pfam00874 1001582010855 PRD domain; Region: PRD; pfam00874 1001582010856 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1001582010857 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1001582010858 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1001582010859 putative active site [active] 1001582010860 catalytic triad [active] 1001582010861 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1001582010862 PA/protease domain interface [polypeptide binding]; other site 1001582010863 putative integrin binding motif; other site 1001582010864 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1001582010865 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1001582010866 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1001582010867 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1001582010868 Predicted transcriptional regulator [Transcription]; Region: COG2378 1001582010869 HTH domain; Region: HTH_11; pfam08279 1001582010870 WYL domain; Region: WYL; pfam13280 1001582010871 short chain dehydrogenase; Provisional; Region: PRK06523 1001582010872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1001582010873 NAD(P) binding site [chemical binding]; other site 1001582010874 active site 1001582010875 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1001582010876 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1001582010877 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1001582010878 dimer interface [polypeptide binding]; other site 1001582010879 FMN binding site [chemical binding]; other site 1001582010880 NADPH bind site [chemical binding]; other site 1001582010881 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1001582010882 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1001582010883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582010884 Coenzyme A binding pocket [chemical binding]; other site 1001582010885 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1001582010886 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1001582010887 Subunit I/III interface [polypeptide binding]; other site 1001582010888 Subunit III/IV interface [polypeptide binding]; other site 1001582010889 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1001582010890 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1001582010891 D-pathway; other site 1001582010892 Putative ubiquinol binding site [chemical binding]; other site 1001582010893 Low-spin heme (heme b) binding site [chemical binding]; other site 1001582010894 Putative water exit pathway; other site 1001582010895 Binuclear center (heme o3/CuB) [ion binding]; other site 1001582010896 K-pathway; other site 1001582010897 Putative proton exit pathway; other site 1001582010898 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1001582010899 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1001582010900 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1001582010901 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1001582010902 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1001582010903 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1001582010904 galactokinase; Provisional; Region: PRK05322 1001582010905 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1001582010906 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1001582010907 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1001582010908 Predicted membrane protein [Function unknown]; Region: COG2246 1001582010909 GtrA-like protein; Region: GtrA; pfam04138 1001582010910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582010911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582010912 Uso1 / p115 like vesicle tethering protein, head region; Region: Uso1_p115_head; pfam04869 1001582010913 Anti-repressor SinI; Region: SinI; pfam08671 1001582010914 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1001582010915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582010916 S-adenosylmethionine binding site [chemical binding]; other site 1001582010917 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1001582010918 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1001582010919 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1001582010920 catalytic residues [active] 1001582010921 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1001582010922 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1001582010923 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1001582010924 Imelysin; Region: Peptidase_M75; pfam09375 1001582010925 FTR1 family protein; Region: TIGR00145 1001582010926 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1001582010927 thiamine phosphate binding site [chemical binding]; other site 1001582010928 active site 1001582010929 pyrophosphate binding site [ion binding]; other site 1001582010930 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1001582010931 substrate binding site [chemical binding]; other site 1001582010932 multimerization interface [polypeptide binding]; other site 1001582010933 ATP binding site [chemical binding]; other site 1001582010934 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1001582010935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1001582010936 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1001582010937 putative dimerization interface [polypeptide binding]; other site 1001582010938 LrgA family; Region: LrgA; cl00608 1001582010939 LrgB-like family; Region: LrgB; cl00596 1001582010940 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1001582010941 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1001582010942 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1001582010943 DNA binding residues [nucleotide binding] 1001582010944 dimer interface [polypeptide binding]; other site 1001582010945 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1001582010946 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1001582010947 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1001582010948 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1001582010949 putative RNA binding site [nucleotide binding]; other site 1001582010950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582010951 S-adenosylmethionine binding site [chemical binding]; other site 1001582010952 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1001582010953 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1001582010954 active site 1001582010955 metal binding site [ion binding]; metal-binding site 1001582010956 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1001582010957 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1001582010958 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1001582010959 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1001582010960 active site 1001582010961 catalytic residues [active] 1001582010962 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1001582010963 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1001582010964 Ligand binding site; other site 1001582010965 metal-binding site 1001582010966 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1001582010967 synthetase active site [active] 1001582010968 NTP binding site [chemical binding]; other site 1001582010969 metal binding site [ion binding]; metal-binding site 1001582010970 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1001582010971 UbiA prenyltransferase family; Region: UbiA; pfam01040 1001582010972 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1001582010973 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1001582010974 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1001582010975 acyl-activating enzyme (AAE) consensus motif; other site 1001582010976 AMP binding site [chemical binding]; other site 1001582010977 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1001582010978 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1001582010979 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1001582010980 DltD N-terminal region; Region: DltD_N; pfam04915 1001582010981 DltD central region; Region: DltD_M; pfam04918 1001582010982 DltD C-terminal region; Region: DltD_C; pfam04914 1001582010983 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1001582010984 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1001582010985 homodimer interface [polypeptide binding]; other site 1001582010986 substrate-cofactor binding pocket; other site 1001582010987 catalytic residue [active] 1001582010988 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1001582010989 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1001582010990 NAD binding site [chemical binding]; other site 1001582010991 sugar binding site [chemical binding]; other site 1001582010992 divalent metal binding site [ion binding]; other site 1001582010993 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1001582010994 dimer interface [polypeptide binding]; other site 1001582010995 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1001582010996 methionine cluster; other site 1001582010997 active site 1001582010998 phosphorylation site [posttranslational modification] 1001582010999 metal binding site [ion binding]; metal-binding site 1001582011000 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1001582011001 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1001582011002 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1001582011003 active site 1001582011004 P-loop; other site 1001582011005 phosphorylation site [posttranslational modification] 1001582011006 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1001582011007 active site 1001582011008 DNA binding site [nucleotide binding] 1001582011009 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1001582011010 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1001582011011 ABC-ATPase subunit interface; other site 1001582011012 dimer interface [polypeptide binding]; other site 1001582011013 putative PBP binding regions; other site 1001582011014 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1001582011015 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1001582011016 ABC-ATPase subunit interface; other site 1001582011017 dimer interface [polypeptide binding]; other site 1001582011018 putative PBP binding regions; other site 1001582011019 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1001582011020 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1001582011021 intersubunit interface [polypeptide binding]; other site 1001582011022 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582011023 dimerization interface [polypeptide binding]; other site 1001582011024 putative DNA binding site [nucleotide binding]; other site 1001582011025 putative Zn2+ binding site [ion binding]; other site 1001582011026 arsenical pump membrane protein; Provisional; Region: PRK15445 1001582011027 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1001582011028 transmembrane helices; other site 1001582011029 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1001582011030 active site 1001582011031 P-loop; other site 1001582011032 phosphorylation site [posttranslational modification] 1001582011033 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1001582011034 active site 1001582011035 methionine cluster; other site 1001582011036 phosphorylation site [posttranslational modification] 1001582011037 metal binding site [ion binding]; metal-binding site 1001582011038 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1001582011039 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1001582011040 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1001582011041 beta-galactosidase; Region: BGL; TIGR03356 1001582011042 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1001582011043 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1001582011044 nucleotide binding site [chemical binding]; other site 1001582011045 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1001582011046 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1001582011047 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1001582011048 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1001582011049 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1001582011050 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1001582011051 tetramer interface [polypeptide binding]; other site 1001582011052 heme binding pocket [chemical binding]; other site 1001582011053 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1001582011054 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1001582011055 active site 1001582011056 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1001582011057 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1001582011058 Na binding site [ion binding]; other site 1001582011059 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1001582011060 putative substrate binding site [chemical binding]; other site 1001582011061 putative ATP binding site [chemical binding]; other site 1001582011062 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1001582011063 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001582011064 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1001582011065 Walker A/P-loop; other site 1001582011066 ATP binding site [chemical binding]; other site 1001582011067 Q-loop/lid; other site 1001582011068 ABC transporter signature motif; other site 1001582011069 Walker B; other site 1001582011070 D-loop; other site 1001582011071 H-loop/switch region; other site 1001582011072 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1001582011073 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1001582011074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582011075 ATP binding site [chemical binding]; other site 1001582011076 Q-loop/lid; other site 1001582011077 ABC transporter signature motif; other site 1001582011078 Walker B; other site 1001582011079 D-loop; other site 1001582011080 H-loop/switch region; other site 1001582011081 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1001582011082 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1001582011083 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1001582011084 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1001582011085 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1001582011086 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1001582011087 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1001582011088 putative active site [active] 1001582011089 putative metal binding site [ion binding]; other site 1001582011090 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1001582011091 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1001582011092 Walker A/P-loop; other site 1001582011093 ATP binding site [chemical binding]; other site 1001582011094 Q-loop/lid; other site 1001582011095 ABC transporter signature motif; other site 1001582011096 Walker B; other site 1001582011097 D-loop; other site 1001582011098 H-loop/switch region; other site 1001582011099 TOBE domain; Region: TOBE; pfam03459 1001582011100 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1001582011101 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1001582011102 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1001582011103 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001582011104 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1001582011105 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1001582011106 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1001582011107 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1001582011108 UDP-glucose 4-epimerase; Region: PLN02240 1001582011109 NAD binding site [chemical binding]; other site 1001582011110 homodimer interface [polypeptide binding]; other site 1001582011111 active site 1001582011112 substrate binding site [chemical binding]; other site 1001582011113 peptidase T; Region: peptidase-T; TIGR01882 1001582011114 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1001582011115 metal binding site [ion binding]; metal-binding site 1001582011116 dimer interface [polypeptide binding]; other site 1001582011117 Tubby C 2; Region: Tub_2; cl02043 1001582011118 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1001582011119 substrate binding site [chemical binding]; other site 1001582011120 THF binding site; other site 1001582011121 zinc-binding site [ion binding]; other site 1001582011122 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1001582011123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582011124 S-adenosylmethionine binding site [chemical binding]; other site 1001582011125 nucleoside transporter; Region: nupC; TIGR00804 1001582011126 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1001582011127 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1001582011128 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1001582011129 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1001582011130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1001582011131 ABC transporter signature motif; other site 1001582011132 Walker B; other site 1001582011133 D-loop; other site 1001582011134 H-loop/switch region; other site 1001582011135 hydroperoxidase II; Provisional; Region: katE; PRK11249 1001582011136 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1001582011137 tetramer interface [polypeptide binding]; other site 1001582011138 heme binding pocket [chemical binding]; other site 1001582011139 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1001582011140 domain interactions; other site 1001582011141 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1001582011142 Citrate transporter; Region: CitMHS; pfam03600 1001582011143 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1001582011144 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1001582011145 active site 1001582011146 active site 1001582011147 catalytic residues [active] 1001582011148 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1001582011149 CAT RNA binding domain; Region: CAT_RBD; smart01061 1001582011150 PRD domain; Region: PRD; pfam00874 1001582011151 PRD domain; Region: PRD; pfam00874 1001582011152 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1001582011153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582011154 putative substrate translocation pore; other site 1001582011155 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1001582011156 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1001582011157 ATP binding site [chemical binding]; other site 1001582011158 Mg++ binding site [ion binding]; other site 1001582011159 motif III; other site 1001582011160 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1001582011161 nucleotide binding region [chemical binding]; other site 1001582011162 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1001582011163 RNA binding site [nucleotide binding]; other site 1001582011164 YxiJ-like protein; Region: YxiJ; pfam14176 1001582011165 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1001582011166 Amb_all domain; Region: Amb_all; smart00656 1001582011167 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1001582011168 EamA-like transporter family; Region: EamA; pfam00892 1001582011169 EamA-like transporter family; Region: EamA; pfam00892 1001582011170 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1001582011171 Ligand Binding Site [chemical binding]; other site 1001582011172 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1001582011173 beta-galactosidase; Region: BGL; TIGR03356 1001582011174 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1001582011175 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1001582011176 active site turn [active] 1001582011177 phosphorylation site [posttranslational modification] 1001582011178 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1001582011179 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1001582011180 HPr interaction site; other site 1001582011181 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1001582011182 active site 1001582011183 phosphorylation site [posttranslational modification] 1001582011184 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1001582011185 additional DNA contacts [nucleotide binding]; other site 1001582011186 mismatch recognition site; other site 1001582011187 active site 1001582011188 zinc binding site [ion binding]; other site 1001582011189 DNA intercalation site [nucleotide binding]; other site 1001582011190 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1001582011191 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1001582011192 cofactor binding site; other site 1001582011193 DNA binding site [nucleotide binding] 1001582011194 substrate interaction site [chemical binding]; other site 1001582011195 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1001582011196 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1001582011197 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1001582011198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582011199 ATP binding site [chemical binding]; other site 1001582011200 G-X-G motif; other site 1001582011201 Z1 domain; Region: Z1; pfam10593 1001582011202 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 1001582011203 AIPR protein; Region: AIPR; pfam10592 1001582011204 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1001582011205 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1001582011206 substrate binding site [chemical binding]; other site 1001582011207 active site 1001582011208 anti-terminator HutP; Provisional; Region: hutP; PRK03065 1001582011209 RNA binding site [nucleotide binding]; other site 1001582011210 hexamer interface [polypeptide binding]; other site 1001582011211 Histidine-zinc binding site [chemical binding]; other site 1001582011212 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1001582011213 active sites [active] 1001582011214 tetramer interface [polypeptide binding]; other site 1001582011215 urocanate hydratase; Provisional; Region: PRK05414 1001582011216 imidazolonepropionase; Validated; Region: PRK09356 1001582011217 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1001582011218 active site 1001582011219 Agmatinase-like family; Region: Agmatinase-like; cd09990 1001582011220 agmatinase; Region: agmatinase; TIGR01230 1001582011221 active site 1001582011222 oligomer interface [polypeptide binding]; other site 1001582011223 Mn binding site [ion binding]; other site 1001582011224 S-methylmethionine transporter; Provisional; Region: PRK11387 1001582011225 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1001582011226 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1001582011227 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1001582011228 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1001582011229 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1001582011230 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1001582011231 Nucleoside recognition; Region: Gate; pfam07670 1001582011232 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1001582011233 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1001582011234 intersubunit interface [polypeptide binding]; other site 1001582011235 active site 1001582011236 catalytic residue [active] 1001582011237 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1001582011238 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1001582011239 non-specific DNA interactions [nucleotide binding]; other site 1001582011240 DNA binding site [nucleotide binding] 1001582011241 sequence specific DNA binding site [nucleotide binding]; other site 1001582011242 putative cAMP binding site [chemical binding]; other site 1001582011243 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1001582011244 sugar phosphate phosphatase; Provisional; Region: PRK10513 1001582011245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582011246 active site 1001582011247 motif I; other site 1001582011248 motif II; other site 1001582011249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1001582011250 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1001582011251 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1001582011252 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1001582011253 putative ligand binding residues [chemical binding]; other site 1001582011254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1001582011255 FtsX-like permease family; Region: FtsX; pfam02687 1001582011256 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1001582011257 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1001582011258 Walker A/P-loop; other site 1001582011259 ATP binding site [chemical binding]; other site 1001582011260 Q-loop/lid; other site 1001582011261 ABC transporter signature motif; other site 1001582011262 Walker B; other site 1001582011263 D-loop; other site 1001582011264 H-loop/switch region; other site 1001582011265 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001582011266 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1001582011267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582011268 ATP binding site [chemical binding]; other site 1001582011269 Mg2+ binding site [ion binding]; other site 1001582011270 G-X-G motif; other site 1001582011271 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001582011272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582011273 active site 1001582011274 phosphorylation site [posttranslational modification] 1001582011275 intermolecular recognition site; other site 1001582011276 dimerization interface [polypeptide binding]; other site 1001582011277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001582011278 DNA binding site [nucleotide binding] 1001582011279 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1001582011280 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1001582011281 intersubunit interface [polypeptide binding]; other site 1001582011282 active site 1001582011283 zinc binding site [ion binding]; other site 1001582011284 Na+ binding site [ion binding]; other site 1001582011285 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1001582011286 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1001582011287 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1001582011288 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1001582011289 DNA interaction; other site 1001582011290 Metal-binding active site; metal-binding site 1001582011291 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1001582011292 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1001582011293 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1001582011294 Glucuronate isomerase; Region: UxaC; cl00829 1001582011295 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582011296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582011297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582011298 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1001582011299 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1001582011300 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1001582011301 PYR/PP interface [polypeptide binding]; other site 1001582011302 dimer interface [polypeptide binding]; other site 1001582011303 TPP binding site [chemical binding]; other site 1001582011304 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1001582011305 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1001582011306 TPP-binding site; other site 1001582011307 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1001582011308 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1001582011309 substrate binding site [chemical binding]; other site 1001582011310 ATP binding site [chemical binding]; other site 1001582011311 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1001582011312 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1001582011313 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1001582011314 tetrameric interface [polypeptide binding]; other site 1001582011315 NAD binding site [chemical binding]; other site 1001582011316 catalytic residues [active] 1001582011317 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1001582011318 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1001582011319 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1001582011320 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001582011321 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001582011322 active site 1001582011323 catalytic tetrad [active] 1001582011324 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1001582011325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582011326 putative substrate translocation pore; other site 1001582011327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582011328 heat shock protein 90; Provisional; Region: PRK05218 1001582011329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582011330 ATP binding site [chemical binding]; other site 1001582011331 Mg2+ binding site [ion binding]; other site 1001582011332 G-X-G motif; other site 1001582011333 short chain dehydrogenase; Validated; Region: PRK08589 1001582011334 classical (c) SDRs; Region: SDR_c; cd05233 1001582011335 NAD(P) binding site [chemical binding]; other site 1001582011336 active site 1001582011337 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1001582011338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582011339 active site 1001582011340 phosphorylation site [posttranslational modification] 1001582011341 intermolecular recognition site; other site 1001582011342 dimerization interface [polypeptide binding]; other site 1001582011343 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1001582011344 DNA binding residues [nucleotide binding] 1001582011345 dimerization interface [polypeptide binding]; other site 1001582011346 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1001582011347 Histidine kinase; Region: HisKA_3; pfam07730 1001582011348 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1001582011349 ATP binding site [chemical binding]; other site 1001582011350 Mg2+ binding site [ion binding]; other site 1001582011351 G-X-G motif; other site 1001582011352 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1001582011353 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1001582011354 putative di-iron ligands [ion binding]; other site 1001582011355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582011356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582011357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1001582011358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1001582011359 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1001582011360 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1001582011361 NAD(P) binding site [chemical binding]; other site 1001582011362 catalytic residues [active] 1001582011363 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1001582011364 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1001582011365 Trp docking motif [polypeptide binding]; other site 1001582011366 active site 1001582011367 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1001582011368 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582011369 putative DNA binding site [nucleotide binding]; other site 1001582011370 dimerization interface [polypeptide binding]; other site 1001582011371 putative Zn2+ binding site [ion binding]; other site 1001582011372 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1001582011373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582011374 putative substrate translocation pore; other site 1001582011375 RDD family; Region: RDD; pfam06271 1001582011376 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1001582011377 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1001582011378 active site 1001582011379 peroxiredoxin; Region: AhpC; TIGR03137 1001582011380 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1001582011381 dimer interface [polypeptide binding]; other site 1001582011382 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1001582011383 catalytic triad [active] 1001582011384 peroxidatic and resolving cysteines [active] 1001582011385 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1001582011386 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1001582011387 catalytic residue [active] 1001582011388 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1001582011389 catalytic residues [active] 1001582011390 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1001582011391 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1001582011392 Major royal jelly protein; Region: MRJP; pfam03022 1001582011393 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1001582011394 HTH domain; Region: HTH_11; pfam08279 1001582011395 WYL domain; Region: WYL; pfam13280 1001582011396 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1001582011397 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1001582011398 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1001582011399 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1001582011400 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1001582011401 catalytic residues [active] 1001582011402 catalytic nucleophile [active] 1001582011403 Presynaptic Site I dimer interface [polypeptide binding]; other site 1001582011404 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1001582011405 Synaptic Flat tetramer interface [polypeptide binding]; other site 1001582011406 Synaptic Site I dimer interface [polypeptide binding]; other site 1001582011407 DNA binding site [nucleotide binding] 1001582011408 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 1001582011409 DNA-binding interface [nucleotide binding]; DNA binding site 1001582011410 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1001582011411 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1001582011412 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1001582011413 stage V sporulation protein AD; Provisional; Region: PRK12404 1001582011414 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 1001582011415 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1001582011416 Predicted membrane protein [Function unknown]; Region: COG2323 1001582011417 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 1001582011418 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1001582011419 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1001582011420 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1001582011421 putative active site [active] 1001582011422 catalytic site [active] 1001582011423 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1001582011424 putative active site [active] 1001582011425 catalytic site [active] 1001582011426 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1001582011427 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1001582011428 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1001582011429 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1001582011430 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1001582011431 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1001582011432 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1001582011433 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1001582011434 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1001582011435 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1001582011436 Ligand binding site; other site 1001582011437 metal-binding site 1001582011438 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1001582011439 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1001582011440 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1001582011441 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1001582011442 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1001582011443 Part of AAA domain; Region: AAA_19; pfam13245 1001582011444 AAA ATPase domain; Region: AAA_15; pfam13175 1001582011445 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1001582011446 putative active site [active] 1001582011447 putative metal-binding site [ion binding]; other site 1001582011448 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1001582011449 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1001582011450 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1001582011451 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1001582011452 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1001582011453 active site 1001582011454 catalytic tetrad [active] 1001582011455 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1001582011456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582011457 Coenzyme A binding pocket [chemical binding]; other site 1001582011458 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582011459 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1001582011460 Arginase family; Region: Arginase; cd09989 1001582011461 active site 1001582011462 Mn binding site [ion binding]; other site 1001582011463 oligomer interface [polypeptide binding]; other site 1001582011464 S-methylmethionine transporter; Provisional; Region: PRK11387 1001582011465 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1001582011466 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1001582011467 inhibitor-cofactor binding pocket; inhibition site 1001582011468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1001582011469 catalytic residue [active] 1001582011470 Predicted integral membrane protein [Function unknown]; Region: COG5658 1001582011471 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1001582011472 SdpI/YhfL protein family; Region: SdpI; pfam13630 1001582011473 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582011474 dimerization interface [polypeptide binding]; other site 1001582011475 putative DNA binding site [nucleotide binding]; other site 1001582011476 putative Zn2+ binding site [ion binding]; other site 1001582011477 PAS domain; Region: PAS_9; pfam13426 1001582011478 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1001582011479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1001582011480 Walker A motif; other site 1001582011481 ATP binding site [chemical binding]; other site 1001582011482 Walker B motif; other site 1001582011483 arginine finger; other site 1001582011484 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1001582011485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582011486 putative substrate translocation pore; other site 1001582011487 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1001582011488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1001582011489 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1001582011490 dimerization interface [polypeptide binding]; other site 1001582011491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582011492 dimer interface [polypeptide binding]; other site 1001582011493 phosphorylation site [posttranslational modification] 1001582011494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582011495 ATP binding site [chemical binding]; other site 1001582011496 Mg2+ binding site [ion binding]; other site 1001582011497 G-X-G motif; other site 1001582011498 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001582011499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582011500 active site 1001582011501 phosphorylation site [posttranslational modification] 1001582011502 intermolecular recognition site; other site 1001582011503 dimerization interface [polypeptide binding]; other site 1001582011504 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001582011505 DNA binding site [nucleotide binding] 1001582011506 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1001582011507 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1001582011508 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1001582011509 Predicted membrane protein [Function unknown]; Region: COG3212 1001582011510 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1001582011511 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1001582011512 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1001582011513 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1001582011514 protein binding site [polypeptide binding]; other site 1001582011515 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1001582011516 YycH protein; Region: YycI; cl02015 1001582011517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1001582011518 YycH protein; Region: YycH; pfam07435 1001582011519 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1001582011520 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1001582011521 dimerization interface [polypeptide binding]; other site 1001582011522 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1001582011523 putative active site [active] 1001582011524 heme pocket [chemical binding]; other site 1001582011525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1001582011526 dimer interface [polypeptide binding]; other site 1001582011527 phosphorylation site [posttranslational modification] 1001582011528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1001582011529 ATP binding site [chemical binding]; other site 1001582011530 Mg2+ binding site [ion binding]; other site 1001582011531 G-X-G motif; other site 1001582011532 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1001582011533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1001582011534 active site 1001582011535 phosphorylation site [posttranslational modification] 1001582011536 intermolecular recognition site; other site 1001582011537 dimerization interface [polypeptide binding]; other site 1001582011538 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1001582011539 DNA binding site [nucleotide binding] 1001582011540 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1001582011541 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1001582011542 GDP-binding site [chemical binding]; other site 1001582011543 ACT binding site; other site 1001582011544 IMP binding site; other site 1001582011545 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1001582011546 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1001582011547 active site 1001582011548 replicative DNA helicase; Provisional; Region: PRK05748 1001582011549 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1001582011550 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1001582011551 Walker A motif; other site 1001582011552 ATP binding site [chemical binding]; other site 1001582011553 Walker B motif; other site 1001582011554 DNA binding loops [nucleotide binding] 1001582011555 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1001582011556 YycC-like protein; Region: YycC; pfam14174 1001582011557 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001582011558 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1001582011559 Phosphotransferase enzyme family; Region: APH; pfam01636 1001582011560 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1001582011561 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 1001582011562 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1001582011563 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1001582011564 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1001582011565 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1001582011566 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1001582011567 active site 1001582011568 substrate binding site [chemical binding]; other site 1001582011569 ATP binding site [chemical binding]; other site 1001582011570 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1001582011571 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1001582011572 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1001582011573 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1001582011574 diguanylate cyclase; Region: GGDEF; smart00267 1001582011575 DHH family; Region: DHH; pfam01368 1001582011576 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 1001582011577 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1001582011578 Predicted transcriptional regulators [Transcription]; Region: COG1733 1001582011579 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1001582011580 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1001582011581 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1001582011582 DHHA2 domain; Region: DHHA2; pfam02833 1001582011583 EamA-like transporter family; Region: EamA; pfam00892 1001582011584 EamA-like transporter family; Region: EamA; pfam00892 1001582011585 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1001582011586 active site 1001582011587 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1001582011588 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1001582011589 substrate binding [chemical binding]; other site 1001582011590 active site 1001582011591 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1001582011592 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1001582011593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1001582011594 DNA-binding site [nucleotide binding]; DNA binding site 1001582011595 FCD domain; Region: FCD; pfam07729 1001582011596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1001582011597 H+ Antiporter protein; Region: 2A0121; TIGR00900 1001582011598 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1001582011599 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1001582011600 dimer interface [polypeptide binding]; other site 1001582011601 FMN binding site [chemical binding]; other site 1001582011602 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582011603 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1001582011604 putative DNA binding site [nucleotide binding]; other site 1001582011605 putative Zn2+ binding site [ion binding]; other site 1001582011606 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1001582011607 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1001582011608 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1001582011609 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1001582011610 MarR family; Region: MarR; pfam01047 1001582011611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582011612 Coenzyme A binding pocket [chemical binding]; other site 1001582011613 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1001582011614 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1001582011615 TAP-like protein; Region: Abhydrolase_4; pfam08386 1001582011616 CAAX protease self-immunity; Region: Abi; pfam02517 1001582011617 benzoate transport; Region: 2A0115; TIGR00895 1001582011618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582011619 putative substrate translocation pore; other site 1001582011620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1001582011621 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1001582011622 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1001582011623 putative metal binding site [ion binding]; other site 1001582011624 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1001582011625 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1001582011626 DNA binding site [nucleotide binding] 1001582011627 domain linker motif; other site 1001582011628 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1001582011629 putative dimerization interface [polypeptide binding]; other site 1001582011630 putative ligand binding site [chemical binding]; other site 1001582011631 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1001582011632 active site 1001582011633 putative catalytic site [active] 1001582011634 DNA binding site [nucleotide binding] 1001582011635 putative phosphate binding site [ion binding]; other site 1001582011636 metal binding site A [ion binding]; metal-binding site 1001582011637 AP binding site [nucleotide binding]; other site 1001582011638 metal binding site B [ion binding]; metal-binding site 1001582011639 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1001582011640 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1001582011641 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1001582011642 DNA binding site [nucleotide binding] 1001582011643 active site 1001582011644 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1001582011645 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1001582011646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001582011647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1001582011648 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1001582011649 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1001582011650 dimer interface [polypeptide binding]; other site 1001582011651 ssDNA binding site [nucleotide binding]; other site 1001582011652 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1001582011653 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1001582011654 GTP-binding protein YchF; Reviewed; Region: PRK09601 1001582011655 YchF GTPase; Region: YchF; cd01900 1001582011656 G1 box; other site 1001582011657 GTP/Mg2+ binding site [chemical binding]; other site 1001582011658 Switch I region; other site 1001582011659 G2 box; other site 1001582011660 Switch II region; other site 1001582011661 G3 box; other site 1001582011662 G4 box; other site 1001582011663 G5 box; other site 1001582011664 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1001582011665 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1001582011666 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1001582011667 putative [4Fe-4S] binding site [ion binding]; other site 1001582011668 putative molybdopterin cofactor binding site [chemical binding]; other site 1001582011669 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1001582011670 molybdopterin cofactor binding site; other site 1001582011671 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1001582011672 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1001582011673 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1001582011674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1001582011675 Coenzyme A binding pocket [chemical binding]; other site 1001582011676 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1001582011677 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1001582011678 ParB-like nuclease domain; Region: ParB; smart00470 1001582011679 KorB domain; Region: KorB; pfam08535 1001582011680 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1001582011681 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1001582011682 P-loop; other site 1001582011683 Magnesium ion binding site [ion binding]; other site 1001582011684 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1001582011685 Magnesium ion binding site [ion binding]; other site 1001582011686 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1001582011687 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1001582011688 ParB-like nuclease domain; Region: ParB; smart00470 1001582011689 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1001582011690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1001582011691 S-adenosylmethionine binding site [chemical binding]; other site 1001582011692 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1001582011693 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1001582011694 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1001582011695 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1001582011696 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1001582011697 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1001582011698 G1 box; other site 1001582011699 GTP/Mg2+ binding site [chemical binding]; other site 1001582011700 Switch I region; other site 1001582011701 G2 box; other site 1001582011702 Switch II region; other site 1001582011703 G3 box; other site 1001582011704 G4 box; other site 1001582011705 G5 box; other site 1001582011706 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1001582011707 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1001582011708 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1001582011709 G-X-X-G motif; other site 1001582011710 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1001582011711 RxxxH motif; other site 1001582011712 OxaA-like protein precursor; Validated; Region: PRK02944 1001582011713 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1001582011714 ribonuclease P; Reviewed; Region: rnpA; PRK00499