-- dump date 20140618_211725 -- class Genbank::misc_feature -- table misc_feature_note -- id note 999891000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 999891000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 999891000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891000004 Walker A motif; other site 999891000005 ATP binding site [chemical binding]; other site 999891000006 Walker B motif; other site 999891000007 arginine finger; other site 999891000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 999891000009 DnaA box-binding interface [nucleotide binding]; other site 999891000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 999891000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 999891000012 putative DNA binding surface [nucleotide binding]; other site 999891000013 dimer interface [polypeptide binding]; other site 999891000014 beta-clamp/clamp loader binding surface; other site 999891000015 beta-clamp/translesion DNA polymerase binding surface; other site 999891000016 S4 domain; Region: S4_2; pfam13275 999891000017 recombination protein F; Reviewed; Region: recF; PRK00064 999891000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 999891000019 Walker A/P-loop; other site 999891000020 ATP binding site [chemical binding]; other site 999891000021 Q-loop/lid; other site 999891000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891000023 ABC transporter signature motif; other site 999891000024 Walker B; other site 999891000025 D-loop; other site 999891000026 H-loop/switch region; other site 999891000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 999891000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891000029 ATP binding site [chemical binding]; other site 999891000030 Mg2+ binding site [ion binding]; other site 999891000031 G-X-G motif; other site 999891000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 999891000033 anchoring element; other site 999891000034 dimer interface [polypeptide binding]; other site 999891000035 ATP binding site [chemical binding]; other site 999891000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 999891000037 active site 999891000038 putative metal-binding site [ion binding]; other site 999891000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 999891000040 DNA gyrase subunit A; Validated; Region: PRK05560 999891000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 999891000042 CAP-like domain; other site 999891000043 active site 999891000044 primary dimer interface [polypeptide binding]; other site 999891000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999891000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999891000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999891000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999891000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999891000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999891000051 potential RNA of insufficient length (16S ribosomal RNA) 999891000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 999891000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 999891000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 999891000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 999891000056 active site 999891000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 999891000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 999891000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 999891000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 999891000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 999891000062 active site 999891000063 multimer interface [polypeptide binding]; other site 999891000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 999891000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 999891000066 predicted active site [active] 999891000067 catalytic triad [active] 999891000068 seryl-tRNA synthetase; Provisional; Region: PRK05431 999891000069 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 999891000070 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 999891000071 dimer interface [polypeptide binding]; other site 999891000072 active site 999891000073 motif 1; other site 999891000074 motif 2; other site 999891000075 motif 3; other site 999891000076 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 999891000077 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 999891000078 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 999891000079 Substrate-binding site [chemical binding]; other site 999891000080 Substrate specificity [chemical binding]; other site 999891000081 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 999891000082 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 999891000083 Substrate-binding site [chemical binding]; other site 999891000084 Substrate specificity [chemical binding]; other site 999891000085 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 999891000086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891000087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891000088 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 999891000089 active site 999891000090 Isochorismatase family; Region: Isochorismatase; pfam00857 999891000091 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 999891000092 catalytic triad [active] 999891000093 conserved cis-peptide bond; other site 999891000094 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 999891000095 nucleoside/Zn binding site; other site 999891000096 dimer interface [polypeptide binding]; other site 999891000097 catalytic motif [active] 999891000098 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 999891000099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891000100 Walker A motif; other site 999891000101 ATP binding site [chemical binding]; other site 999891000102 Walker B motif; other site 999891000103 arginine finger; other site 999891000104 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 999891000105 hypothetical protein; Validated; Region: PRK00153 999891000106 recombination protein RecR; Reviewed; Region: recR; PRK00076 999891000107 RecR protein; Region: RecR; pfam02132 999891000108 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 999891000109 putative active site [active] 999891000110 putative metal-binding site [ion binding]; other site 999891000111 tetramer interface [polypeptide binding]; other site 999891000112 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 999891000113 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 999891000114 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 999891000115 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 999891000116 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 999891000117 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 999891000118 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 999891000119 homodimer interface [polypeptide binding]; other site 999891000120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891000121 catalytic residue [active] 999891000122 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 999891000123 thymidylate kinase; Validated; Region: tmk; PRK00698 999891000124 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 999891000125 TMP-binding site; other site 999891000126 ATP-binding site [chemical binding]; other site 999891000127 Protein of unknown function (DUF970); Region: DUF970; pfam06153 999891000128 Protein of unknown function (DUF327); Region: DUF327; pfam03885 999891000129 DNA polymerase III subunit delta'; Validated; Region: PRK08058 999891000130 DNA polymerase III subunit delta'; Validated; Region: PRK08485 999891000131 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 999891000132 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 999891000133 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 999891000134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891000135 S-adenosylmethionine binding site [chemical binding]; other site 999891000136 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 999891000137 GIY-YIG motif/motif A; other site 999891000138 putative active site [active] 999891000139 putative metal binding site [ion binding]; other site 999891000140 Predicted methyltransferases [General function prediction only]; Region: COG0313 999891000141 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 999891000142 putative SAM binding site [chemical binding]; other site 999891000143 putative homodimer interface [polypeptide binding]; other site 999891000144 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 999891000145 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 999891000146 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 999891000147 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 999891000148 active site 999891000149 HIGH motif; other site 999891000150 KMSKS motif; other site 999891000151 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 999891000152 tRNA binding surface [nucleotide binding]; other site 999891000153 anticodon binding site; other site 999891000154 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 999891000155 dimer interface [polypeptide binding]; other site 999891000156 putative tRNA-binding site [nucleotide binding]; other site 999891000157 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 999891000158 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 999891000159 active site 999891000160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 999891000161 Domain of unknown function (DUF348); Region: DUF348; pfam03990 999891000162 Domain of unknown function (DUF348); Region: DUF348; pfam03990 999891000163 Domain of unknown function (DUF348); Region: DUF348; pfam03990 999891000164 G5 domain; Region: G5; pfam07501 999891000165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 999891000166 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 999891000167 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 999891000168 putative active site [active] 999891000169 putative metal binding site [ion binding]; other site 999891000170 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 999891000171 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 999891000172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891000173 S-adenosylmethionine binding site [chemical binding]; other site 999891000174 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 999891000175 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 999891000176 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 999891000177 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 999891000178 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 999891000179 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 999891000180 pur operon repressor; Provisional; Region: PRK09213 999891000181 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 999891000182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999891000183 active site 999891000184 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 999891000185 homotrimer interaction site [polypeptide binding]; other site 999891000186 putative active site [active] 999891000187 regulatory protein SpoVG; Reviewed; Region: PRK13259 999891000188 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 999891000189 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 999891000190 Substrate binding site; other site 999891000191 Mg++ binding site; other site 999891000192 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 999891000193 active site 999891000194 substrate binding site [chemical binding]; other site 999891000195 CoA binding site [chemical binding]; other site 999891000196 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 999891000197 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 999891000198 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999891000199 active site 999891000200 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 999891000201 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 999891000202 5S rRNA interface [nucleotide binding]; other site 999891000203 CTC domain interface [polypeptide binding]; other site 999891000204 L16 interface [polypeptide binding]; other site 999891000205 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 999891000206 putative active site [active] 999891000207 catalytic residue [active] 999891000208 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 999891000209 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 999891000210 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 999891000211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999891000212 ATP binding site [chemical binding]; other site 999891000213 putative Mg++ binding site [ion binding]; other site 999891000214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999891000215 nucleotide binding region [chemical binding]; other site 999891000216 ATP-binding site [chemical binding]; other site 999891000217 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 999891000218 stage V sporulation protein T; Region: spore_V_T; TIGR02851 999891000219 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 999891000220 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 999891000221 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 999891000222 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 999891000223 putative SAM binding site [chemical binding]; other site 999891000224 putative homodimer interface [polypeptide binding]; other site 999891000225 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 999891000226 homodimer interface [polypeptide binding]; other site 999891000227 metal binding site [ion binding]; metal-binding site 999891000228 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 999891000229 homodimer interface [polypeptide binding]; other site 999891000230 active site 999891000231 putative chemical substrate binding site [chemical binding]; other site 999891000232 metal binding site [ion binding]; metal-binding site 999891000233 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999891000234 RNA binding surface [nucleotide binding]; other site 999891000235 sporulation protein YabP; Region: spore_yabP; TIGR02892 999891000236 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 999891000237 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 999891000238 Septum formation initiator; Region: DivIC; pfam04977 999891000239 hypothetical protein; Provisional; Region: PRK08582 999891000240 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 999891000241 RNA binding site [nucleotide binding]; other site 999891000242 stage II sporulation protein E; Region: spore_II_E; TIGR02865 999891000243 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 999891000244 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 999891000245 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 999891000246 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 999891000247 metal ion-dependent adhesion site (MIDAS); other site 999891000248 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 999891000249 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 999891000250 active site 999891000251 ATP binding site [chemical binding]; other site 999891000252 substrate binding site [chemical binding]; other site 999891000253 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 999891000254 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 999891000255 Ligand Binding Site [chemical binding]; other site 999891000256 TilS substrate C-terminal domain; Region: TilS_C; smart00977 999891000257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999891000258 active site 999891000259 FtsH Extracellular; Region: FtsH_ext; pfam06480 999891000260 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 999891000261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891000262 Walker A motif; other site 999891000263 ATP binding site [chemical binding]; other site 999891000264 Walker B motif; other site 999891000265 arginine finger; other site 999891000266 Peptidase family M41; Region: Peptidase_M41; pfam01434 999891000267 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 999891000268 nucleotide binding site [chemical binding]; other site 999891000269 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 999891000270 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 999891000271 dimerization interface [polypeptide binding]; other site 999891000272 domain crossover interface; other site 999891000273 redox-dependent activation switch; other site 999891000274 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 999891000275 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 999891000276 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 999891000277 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 999891000278 dimer interface [polypeptide binding]; other site 999891000279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891000280 catalytic residue [active] 999891000281 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 999891000282 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 999891000283 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 999891000284 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 999891000285 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 999891000286 glutamine binding [chemical binding]; other site 999891000287 catalytic triad [active] 999891000288 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 999891000289 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 999891000290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891000291 catalytic residue [active] 999891000292 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 999891000293 dihydropteroate synthase; Region: DHPS; TIGR01496 999891000294 substrate binding pocket [chemical binding]; other site 999891000295 dimer interface [polypeptide binding]; other site 999891000296 inhibitor binding site; inhibition site 999891000297 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 999891000298 homooctamer interface [polypeptide binding]; other site 999891000299 active site 999891000300 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 999891000301 catalytic center binding site [active] 999891000302 ATP binding site [chemical binding]; other site 999891000303 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999891000304 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891000305 non-specific DNA binding site [nucleotide binding]; other site 999891000306 salt bridge; other site 999891000307 sequence-specific DNA binding site [nucleotide binding]; other site 999891000308 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 999891000309 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 999891000310 FMN binding site [chemical binding]; other site 999891000311 active site 999891000312 catalytic residues [active] 999891000313 substrate binding site [chemical binding]; other site 999891000314 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 999891000315 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 999891000316 dimer interface [polypeptide binding]; other site 999891000317 putative anticodon binding site; other site 999891000318 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 999891000319 motif 1; other site 999891000320 active site 999891000321 motif 2; other site 999891000322 motif 3; other site 999891000323 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 999891000324 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 999891000325 UvrB/uvrC motif; Region: UVR; pfam02151 999891000326 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 999891000327 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 999891000328 ADP binding site [chemical binding]; other site 999891000329 phosphagen binding site; other site 999891000330 substrate specificity loop; other site 999891000331 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 999891000332 Clp amino terminal domain; Region: Clp_N; pfam02861 999891000333 Clp amino terminal domain; Region: Clp_N; pfam02861 999891000334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891000335 Walker A motif; other site 999891000336 ATP binding site [chemical binding]; other site 999891000337 Walker B motif; other site 999891000338 arginine finger; other site 999891000339 UvrB/uvrC motif; Region: UVR; pfam02151 999891000340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891000341 Walker A motif; other site 999891000342 ATP binding site [chemical binding]; other site 999891000343 Walker B motif; other site 999891000344 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 999891000345 DNA repair protein RadA; Provisional; Region: PRK11823 999891000346 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 999891000347 Walker A motif/ATP binding site; other site 999891000348 ATP binding site [chemical binding]; other site 999891000349 Walker B motif; other site 999891000350 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 999891000351 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 999891000352 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 999891000353 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 999891000354 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 999891000355 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 999891000356 putative active site [active] 999891000357 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 999891000358 substrate binding site; other site 999891000359 dimer interface; other site 999891000360 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 999891000361 homotrimer interaction site [polypeptide binding]; other site 999891000362 zinc binding site [ion binding]; other site 999891000363 CDP-binding sites; other site 999891000364 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 999891000365 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 999891000366 HIGH motif; other site 999891000367 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 999891000368 active site 999891000369 KMSKS motif; other site 999891000370 serine O-acetyltransferase; Region: cysE; TIGR01172 999891000371 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 999891000372 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 999891000373 trimer interface [polypeptide binding]; other site 999891000374 active site 999891000375 substrate binding site [chemical binding]; other site 999891000376 CoA binding site [chemical binding]; other site 999891000377 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 999891000378 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 999891000379 active site 999891000380 HIGH motif; other site 999891000381 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 999891000382 KMSKS motif; other site 999891000383 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 999891000384 tRNA binding surface [nucleotide binding]; other site 999891000385 anticodon binding site; other site 999891000386 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 999891000387 active site 999891000388 metal binding site [ion binding]; metal-binding site 999891000389 dimerization interface [polypeptide binding]; other site 999891000390 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 999891000391 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 999891000392 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 999891000393 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 999891000394 RNA polymerase factor sigma-70; Validated; Region: PRK08295 999891000395 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999891000396 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 999891000397 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 999891000398 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 999891000399 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 999891000400 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 999891000401 putative homodimer interface [polypeptide binding]; other site 999891000402 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 999891000403 heterodimer interface [polypeptide binding]; other site 999891000404 homodimer interface [polypeptide binding]; other site 999891000405 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 999891000406 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 999891000407 23S rRNA interface [nucleotide binding]; other site 999891000408 L7/L12 interface [polypeptide binding]; other site 999891000409 putative thiostrepton binding site; other site 999891000410 L25 interface [polypeptide binding]; other site 999891000411 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 999891000412 mRNA/rRNA interface [nucleotide binding]; other site 999891000413 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 999891000414 23S rRNA interface [nucleotide binding]; other site 999891000415 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 999891000416 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 999891000417 core dimer interface [polypeptide binding]; other site 999891000418 peripheral dimer interface [polypeptide binding]; other site 999891000419 L10 interface [polypeptide binding]; other site 999891000420 L11 interface [polypeptide binding]; other site 999891000421 putative EF-Tu interaction site [polypeptide binding]; other site 999891000422 putative EF-G interaction site [polypeptide binding]; other site 999891000423 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 999891000424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891000425 S-adenosylmethionine binding site [chemical binding]; other site 999891000426 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 999891000427 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 999891000428 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 999891000429 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 999891000430 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 999891000431 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 999891000432 RPB1 interaction site [polypeptide binding]; other site 999891000433 RPB10 interaction site [polypeptide binding]; other site 999891000434 RPB11 interaction site [polypeptide binding]; other site 999891000435 RPB3 interaction site [polypeptide binding]; other site 999891000436 RPB12 interaction site [polypeptide binding]; other site 999891000437 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 999891000438 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 999891000439 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 999891000440 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 999891000441 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 999891000442 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 999891000443 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 999891000444 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 999891000445 G-loop; other site 999891000446 DNA binding site [nucleotide binding] 999891000447 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 999891000448 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 999891000449 S17 interaction site [polypeptide binding]; other site 999891000450 S8 interaction site; other site 999891000451 16S rRNA interaction site [nucleotide binding]; other site 999891000452 streptomycin interaction site [chemical binding]; other site 999891000453 23S rRNA interaction site [nucleotide binding]; other site 999891000454 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 999891000455 30S ribosomal protein S7; Validated; Region: PRK05302 999891000456 elongation factor G; Reviewed; Region: PRK00007 999891000457 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 999891000458 G1 box; other site 999891000459 putative GEF interaction site [polypeptide binding]; other site 999891000460 GTP/Mg2+ binding site [chemical binding]; other site 999891000461 Switch I region; other site 999891000462 G2 box; other site 999891000463 G3 box; other site 999891000464 Switch II region; other site 999891000465 G4 box; other site 999891000466 G5 box; other site 999891000467 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 999891000468 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 999891000469 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 999891000470 elongation factor Tu; Reviewed; Region: PRK00049 999891000471 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 999891000472 G1 box; other site 999891000473 GEF interaction site [polypeptide binding]; other site 999891000474 GTP/Mg2+ binding site [chemical binding]; other site 999891000475 Switch I region; other site 999891000476 G2 box; other site 999891000477 G3 box; other site 999891000478 Switch II region; other site 999891000479 G4 box; other site 999891000480 G5 box; other site 999891000481 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 999891000482 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 999891000483 Antibiotic Binding Site [chemical binding]; other site 999891000484 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 999891000485 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 999891000486 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 999891000487 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 999891000488 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 999891000489 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 999891000490 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 999891000491 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 999891000492 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 999891000493 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 999891000494 putative translocon binding site; other site 999891000495 protein-rRNA interface [nucleotide binding]; other site 999891000496 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 999891000497 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 999891000498 G-X-X-G motif; other site 999891000499 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 999891000500 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 999891000501 23S rRNA interface [nucleotide binding]; other site 999891000502 5S rRNA interface [nucleotide binding]; other site 999891000503 putative antibiotic binding site [chemical binding]; other site 999891000504 L25 interface [polypeptide binding]; other site 999891000505 L27 interface [polypeptide binding]; other site 999891000506 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 999891000507 23S rRNA interface [nucleotide binding]; other site 999891000508 putative translocon interaction site; other site 999891000509 signal recognition particle (SRP54) interaction site; other site 999891000510 L23 interface [polypeptide binding]; other site 999891000511 trigger factor interaction site; other site 999891000512 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 999891000513 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 999891000514 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 999891000515 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 999891000516 RNA binding site [nucleotide binding]; other site 999891000517 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 999891000518 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 999891000519 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 999891000520 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 999891000521 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 999891000522 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 999891000523 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 999891000524 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 999891000525 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 999891000526 5S rRNA interface [nucleotide binding]; other site 999891000527 L27 interface [polypeptide binding]; other site 999891000528 23S rRNA interface [nucleotide binding]; other site 999891000529 L5 interface [polypeptide binding]; other site 999891000530 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 999891000531 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 999891000532 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 999891000533 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 999891000534 23S rRNA binding site [nucleotide binding]; other site 999891000535 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 999891000536 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 999891000537 SecY translocase; Region: SecY; pfam00344 999891000538 adenylate kinase; Reviewed; Region: adk; PRK00279 999891000539 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 999891000540 AMP-binding site [chemical binding]; other site 999891000541 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 999891000542 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 999891000543 active site 999891000544 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 999891000545 rRNA binding site [nucleotide binding]; other site 999891000546 predicted 30S ribosome binding site; other site 999891000547 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 999891000548 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 999891000549 30S ribosomal protein S13; Region: bact_S13; TIGR03631 999891000550 30S ribosomal protein S11; Validated; Region: PRK05309 999891000551 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 999891000552 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 999891000553 alphaNTD homodimer interface [polypeptide binding]; other site 999891000554 alphaNTD - beta interaction site [polypeptide binding]; other site 999891000555 alphaNTD - beta' interaction site [polypeptide binding]; other site 999891000556 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 999891000557 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 999891000558 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 999891000559 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 999891000560 Walker A/P-loop; other site 999891000561 ATP binding site [chemical binding]; other site 999891000562 Q-loop/lid; other site 999891000563 ABC transporter signature motif; other site 999891000564 Walker B; other site 999891000565 D-loop; other site 999891000566 H-loop/switch region; other site 999891000567 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 999891000568 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 999891000569 Walker A/P-loop; other site 999891000570 ATP binding site [chemical binding]; other site 999891000571 Q-loop/lid; other site 999891000572 ABC transporter signature motif; other site 999891000573 Walker B; other site 999891000574 D-loop; other site 999891000575 H-loop/switch region; other site 999891000576 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 999891000577 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 999891000578 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 999891000579 dimerization interface 3.5A [polypeptide binding]; other site 999891000580 active site 999891000581 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 999891000582 23S rRNA interface [nucleotide binding]; other site 999891000583 L3 interface [polypeptide binding]; other site 999891000584 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 999891000585 Methyltransferase domain; Region: Methyltransf_31; pfam13847 999891000586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891000587 S-adenosylmethionine binding site [chemical binding]; other site 999891000588 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 999891000589 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 999891000590 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 999891000591 active site 999891000592 metal binding site [ion binding]; metal-binding site 999891000593 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 999891000594 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 999891000595 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 999891000596 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 999891000597 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 999891000598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891000599 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 999891000600 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 999891000601 inhibitor-cofactor binding pocket; inhibition site 999891000602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891000603 catalytic residue [active] 999891000604 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 999891000605 active site 999891000606 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 999891000607 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 999891000608 NAD(P) binding site [chemical binding]; other site 999891000609 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 999891000610 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 999891000611 Sulfate transporter family; Region: Sulfate_transp; pfam00916 999891000612 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 999891000613 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 999891000614 Sodium Bile acid symporter family; Region: SBF; cl17470 999891000615 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 999891000616 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 999891000617 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 999891000618 ABC-ATPase subunit interface; other site 999891000619 dimer interface [polypeptide binding]; other site 999891000620 putative PBP binding regions; other site 999891000621 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 999891000622 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 999891000623 ABC-ATPase subunit interface; other site 999891000624 dimer interface [polypeptide binding]; other site 999891000625 putative PBP binding regions; other site 999891000626 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 999891000627 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 999891000628 putative ligand binding residues [chemical binding]; other site 999891000629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 999891000630 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 999891000631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 999891000632 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 999891000633 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 999891000634 intersubunit interface [polypeptide binding]; other site 999891000635 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 999891000636 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 999891000637 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 999891000638 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 999891000639 putative periplasmic esterase; Provisional; Region: PRK03642 999891000640 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 999891000641 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 999891000642 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 999891000643 active site turn [active] 999891000644 phosphorylation site [posttranslational modification] 999891000645 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 999891000646 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 999891000647 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 999891000648 putative active site [active] 999891000649 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 999891000650 Uncharacterized conserved protein [Function unknown]; Region: COG1683 999891000651 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 999891000652 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999891000653 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999891000654 DNA binding residues [nucleotide binding] 999891000655 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 999891000656 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 999891000657 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 999891000658 Uncharacterized conserved protein [Function unknown]; Region: COG1624 999891000659 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 999891000660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 999891000661 YbbR-like protein; Region: YbbR; pfam07949 999891000662 YbbR-like protein; Region: YbbR; pfam07949 999891000663 YbbR-like protein; Region: YbbR; pfam07949 999891000664 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 999891000665 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 999891000666 active site 999891000667 substrate binding site [chemical binding]; other site 999891000668 metal binding site [ion binding]; metal-binding site 999891000669 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 999891000670 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 999891000671 glutaminase active site [active] 999891000672 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 999891000673 dimer interface [polypeptide binding]; other site 999891000674 active site 999891000675 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 999891000676 dimer interface [polypeptide binding]; other site 999891000677 active site 999891000678 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 999891000679 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999891000680 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999891000681 active site 999891000682 catalytic tetrad [active] 999891000683 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 999891000684 LrgA family; Region: LrgA; cl00608 999891000685 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891000686 MarR family; Region: MarR; pfam01047 999891000687 putative transport protein YifK; Provisional; Region: PRK10746 999891000688 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 999891000689 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891000690 active site 999891000691 motif I; other site 999891000692 motif II; other site 999891000693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 999891000694 Histidine kinase; Region: HisKA_3; pfam07730 999891000695 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 999891000696 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 999891000697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891000698 active site 999891000699 phosphorylation site [posttranslational modification] 999891000700 intermolecular recognition site; other site 999891000701 dimerization interface [polypeptide binding]; other site 999891000702 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 999891000703 DNA binding residues [nucleotide binding] 999891000704 dimerization interface [polypeptide binding]; other site 999891000705 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 999891000706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891000707 Walker A/P-loop; other site 999891000708 ATP binding site [chemical binding]; other site 999891000709 Q-loop/lid; other site 999891000710 ABC transporter signature motif; other site 999891000711 Walker B; other site 999891000712 D-loop; other site 999891000713 H-loop/switch region; other site 999891000714 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 999891000715 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 999891000716 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 999891000717 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 999891000718 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 999891000719 potential frameshift: common BLAST hit: gi|154684725|ref|YP_001419886.1| YqeB 999891000720 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 999891000721 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 999891000722 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 999891000723 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 999891000724 active site 999891000725 catalytic site [active] 999891000726 metal binding site [ion binding]; metal-binding site 999891000727 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 999891000728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891000729 putative substrate translocation pore; other site 999891000730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891000731 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 999891000732 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 999891000733 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 999891000734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891000735 non-specific DNA binding site [nucleotide binding]; other site 999891000736 salt bridge; other site 999891000737 sequence-specific DNA binding site [nucleotide binding]; other site 999891000738 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 999891000739 Glycerol_dehydrogenase-like; Region: GlyDH-like; cd08550 999891000740 active site 999891000741 NAD binding site [chemical binding]; other site 999891000742 metal binding site [ion binding]; metal-binding site 999891000743 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 999891000744 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 999891000745 ATP-grasp domain; Region: ATP-grasp; pfam02222 999891000746 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 999891000747 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 999891000748 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 999891000749 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 999891000750 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 999891000751 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 999891000752 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 999891000753 active site residue [active] 999891000754 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 999891000755 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 999891000756 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 999891000757 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 999891000758 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 999891000759 homodimer interface [polypeptide binding]; other site 999891000760 substrate-cofactor binding pocket; other site 999891000761 catalytic residue [active] 999891000762 S-methylmethionine transporter; Provisional; Region: PRK11387 999891000763 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 999891000764 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 999891000765 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 999891000766 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 999891000767 glutaminase; Reviewed; Region: PRK12357 999891000768 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 999891000769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999891000770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891000771 ATP binding site [chemical binding]; other site 999891000772 Mg2+ binding site [ion binding]; other site 999891000773 G-X-G motif; other site 999891000774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891000775 Response regulator receiver domain; Region: Response_reg; pfam00072 999891000776 active site 999891000777 phosphorylation site [posttranslational modification] 999891000778 intermolecular recognition site; other site 999891000779 dimerization interface [polypeptide binding]; other site 999891000780 YcbB domain; Region: YcbB; pfam08664 999891000781 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 999891000782 putative active site [active] 999891000783 putative substrate binding site [chemical binding]; other site 999891000784 Phosphotransferase enzyme family; Region: APH; pfam01636 999891000785 ATP binding site [chemical binding]; other site 999891000786 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 999891000787 dodecamer interface 1 [polypeptide binding]; other site 999891000788 dodecamer interface 2 [polypeptide binding]; other site 999891000789 trimer interface [polypeptide binding]; other site 999891000790 TRAP binding interface [polypeptide binding]; other site 999891000791 Zn binding site [ion binding]; other site 999891000792 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 999891000793 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 999891000794 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 999891000795 dimer interface [polypeptide binding]; other site 999891000796 FMN binding site [chemical binding]; other site 999891000797 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 999891000798 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 999891000799 Zn binding site [ion binding]; other site 999891000800 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 999891000801 Zn binding site [ion binding]; other site 999891000802 Predicted membrane protein [Function unknown]; Region: COG2259 999891000803 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 999891000804 catalytic residues [active] 999891000805 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 999891000806 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 999891000807 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 999891000808 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 999891000809 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 999891000810 putative active site [active] 999891000811 putative metal binding site [ion binding]; other site 999891000812 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 999891000813 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 999891000814 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 999891000815 putative substrate binding pocket [chemical binding]; other site 999891000816 AC domain interface; other site 999891000817 catalytic triad [active] 999891000818 AB domain interface; other site 999891000819 interchain disulfide; other site 999891000820 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 999891000821 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 999891000822 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 999891000823 catalytic residue [active] 999891000824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891000825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891000826 putative substrate translocation pore; other site 999891000827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891000828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891000829 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 999891000830 Lipase (class 2); Region: Lipase_2; pfam01674 999891000831 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 999891000832 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 999891000833 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999891000834 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999891000835 active site 999891000836 catalytic tetrad [active] 999891000837 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 999891000838 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 999891000839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891000840 binding surface 999891000841 TPR motif; other site 999891000842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 999891000843 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891000844 TPR motif; other site 999891000845 binding surface 999891000846 glucose-1-dehydrogenase; Provisional; Region: PRK08936 999891000847 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 999891000848 NAD binding site [chemical binding]; other site 999891000849 homodimer interface [polypeptide binding]; other site 999891000850 active site 999891000851 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 999891000852 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 999891000853 Ca binding site [ion binding]; other site 999891000854 active site 999891000855 catalytic site [active] 999891000856 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 999891000857 Predicted transcriptional regulators [Transcription]; Region: COG1695 999891000858 Transcriptional regulator PadR-like family; Region: PadR; cl17335 999891000859 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 999891000860 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 999891000861 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 999891000862 metal binding site [ion binding]; metal-binding site 999891000863 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 999891000864 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 999891000865 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 999891000866 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 999891000867 ABC-ATPase subunit interface; other site 999891000868 dimer interface [polypeptide binding]; other site 999891000869 putative PBP binding regions; other site 999891000870 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 999891000871 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 999891000872 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 999891000873 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 999891000874 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 999891000875 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 999891000876 putative metal binding site [ion binding]; other site 999891000877 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 999891000878 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 999891000879 putative metal binding site [ion binding]; other site 999891000880 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 999891000881 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 999891000882 putative metal binding site [ion binding]; other site 999891000883 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 999891000884 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 999891000885 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 999891000886 benzoate transport; Region: 2A0115; TIGR00895 999891000887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891000888 putative substrate translocation pore; other site 999891000889 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 999891000890 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 999891000891 Walker A/P-loop; other site 999891000892 ATP binding site [chemical binding]; other site 999891000893 Q-loop/lid; other site 999891000894 ABC transporter signature motif; other site 999891000895 Walker B; other site 999891000896 D-loop; other site 999891000897 H-loop/switch region; other site 999891000898 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 999891000899 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 999891000900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891000901 dimer interface [polypeptide binding]; other site 999891000902 conserved gate region; other site 999891000903 putative PBP binding loops; other site 999891000904 ABC-ATPase subunit interface; other site 999891000905 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 999891000906 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 999891000907 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 999891000908 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 999891000909 amidohydrolase; Region: amidohydrolases; TIGR01891 999891000910 metal binding site [ion binding]; metal-binding site 999891000911 putative dimer interface [polypeptide binding]; other site 999891000912 Predicted membrane protein [Function unknown]; Region: COG1288 999891000913 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 999891000914 RDD family; Region: RDD; pfam06271 999891000915 RDD family; Region: RDD; pfam06271 999891000916 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 999891000917 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 999891000918 tetramer (dimer of dimers) interface [polypeptide binding]; other site 999891000919 NAD binding site [chemical binding]; other site 999891000920 dimer interface [polypeptide binding]; other site 999891000921 substrate binding site [chemical binding]; other site 999891000922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891000923 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891000924 putative substrate translocation pore; other site 999891000925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891000926 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891000927 MarR family; Region: MarR; pfam01047 999891000928 LysE type translocator; Region: LysE; pfam01810 999891000929 Uncharacterized conserved protein [Function unknown]; Region: COG3403 999891000930 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 999891000931 Spore germination protein; Region: Spore_permease; cl17796 999891000932 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 999891000933 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 999891000934 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 999891000935 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 999891000936 homodimer interface [polypeptide binding]; other site 999891000937 NAD binding pocket [chemical binding]; other site 999891000938 ATP binding pocket [chemical binding]; other site 999891000939 Mg binding site [ion binding]; other site 999891000940 active-site loop [active] 999891000941 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 999891000942 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 999891000943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891000944 D-galactonate transporter; Region: 2A0114; TIGR00893 999891000945 putative substrate translocation pore; other site 999891000946 shikimate kinase; Reviewed; Region: aroK; PRK00131 999891000947 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 999891000948 ADP binding site [chemical binding]; other site 999891000949 magnesium binding site [ion binding]; other site 999891000950 putative shikimate binding site; other site 999891000951 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 999891000952 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 999891000953 Proline dehydrogenase; Region: Pro_dh; pfam01619 999891000954 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 999891000955 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 999891000956 Glutamate binding site [chemical binding]; other site 999891000957 homodimer interface [polypeptide binding]; other site 999891000958 NAD binding site [chemical binding]; other site 999891000959 catalytic residues [active] 999891000960 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 999891000961 Na binding site [ion binding]; other site 999891000962 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 999891000963 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 999891000964 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 999891000965 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 999891000966 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999891000967 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 999891000968 active site 999891000969 SAM binding site [chemical binding]; other site 999891000970 homodimer interface [polypeptide binding]; other site 999891000971 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 999891000972 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 999891000973 [2Fe-2S] cluster binding site [ion binding]; other site 999891000974 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 999891000975 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999891000976 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 999891000977 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 999891000978 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 999891000979 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 999891000980 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 999891000981 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 999891000982 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 999891000983 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 999891000984 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 999891000985 NAD binding site [chemical binding]; other site 999891000986 catalytic Zn binding site [ion binding]; other site 999891000987 structural Zn binding site [ion binding]; other site 999891000988 RDD family; Region: RDD; pfam06271 999891000989 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 999891000990 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 999891000991 beta-galactosidase; Region: BGL; TIGR03356 999891000992 Competence protein J (ComJ); Region: ComJ; pfam11033 999891000993 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 999891000994 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 999891000995 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 999891000996 tetramer interface [polypeptide binding]; other site 999891000997 active site 999891000998 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 999891000999 active site 999891001000 dimer interface [polypeptide binding]; other site 999891001001 magnesium binding site [ion binding]; other site 999891001002 Predicted transcriptional regulators [Transcription]; Region: COG1733 999891001003 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 999891001004 Condensation domain; Region: Condensation; pfam00668 999891001005 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891001006 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 999891001007 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891001008 acyl-activating enzyme (AAE) consensus motif; other site 999891001009 AMP binding site [chemical binding]; other site 999891001010 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891001011 Condensation domain; Region: Condensation; pfam00668 999891001012 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891001013 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 999891001014 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 999891001015 acyl-activating enzyme (AAE) consensus motif; other site 999891001016 AMP binding site [chemical binding]; other site 999891001017 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891001018 Condensation domain; Region: Condensation; pfam00668 999891001019 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891001020 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 999891001021 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891001022 acyl-activating enzyme (AAE) consensus motif; other site 999891001023 AMP binding site [chemical binding]; other site 999891001024 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891001025 Condensation domain; Region: Condensation; pfam00668 999891001026 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 999891001027 Condensation domain; Region: Condensation; pfam00668 999891001028 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891001029 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 999891001030 acyl-activating enzyme (AAE) consensus motif; other site 999891001031 AMP binding site [chemical binding]; other site 999891001032 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891001033 Condensation domain; Region: Condensation; pfam00668 999891001034 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891001035 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 999891001036 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891001037 acyl-activating enzyme (AAE) consensus motif; other site 999891001038 AMP binding site [chemical binding]; other site 999891001039 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891001040 Condensation domain; Region: Condensation; pfam00668 999891001041 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891001042 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 999891001043 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891001044 acyl-activating enzyme (AAE) consensus motif; other site 999891001045 AMP binding site [chemical binding]; other site 999891001046 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891001047 Condensation domain; Region: Condensation; pfam00668 999891001048 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891001049 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 999891001050 Condensation domain; Region: Condensation; pfam00668 999891001051 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891001052 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 999891001053 acyl-activating enzyme (AAE) consensus motif; other site 999891001054 AMP binding site [chemical binding]; other site 999891001055 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891001056 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 999891001057 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 999891001058 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 999891001059 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 999891001060 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891001061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891001062 homodimer interface [polypeptide binding]; other site 999891001063 catalytic residue [active] 999891001064 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 999891001065 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 999891001066 Predicted membrane protein [Function unknown]; Region: COG2364 999891001067 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999891001068 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 999891001069 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 999891001070 Walker A/P-loop; other site 999891001071 ATP binding site [chemical binding]; other site 999891001072 Q-loop/lid; other site 999891001073 ABC transporter signature motif; other site 999891001074 Walker B; other site 999891001075 D-loop; other site 999891001076 H-loop/switch region; other site 999891001077 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 999891001078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891001079 dimer interface [polypeptide binding]; other site 999891001080 conserved gate region; other site 999891001081 putative PBP binding loops; other site 999891001082 ABC-ATPase subunit interface; other site 999891001083 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 999891001084 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999891001085 substrate binding pocket [chemical binding]; other site 999891001086 membrane-bound complex binding site; other site 999891001087 hinge residues; other site 999891001088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999891001089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999891001090 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 999891001091 dimerization interface [polypeptide binding]; other site 999891001092 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 999891001093 Flavoprotein; Region: Flavoprotein; pfam02441 999891001094 UbiD family decarboxylase; Region: TIGR00148 999891001095 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 999891001096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891001097 putative substrate translocation pore; other site 999891001098 POT family; Region: PTR2; pfam00854 999891001099 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 999891001100 Right handed beta helix region; Region: Beta_helix; pfam13229 999891001101 Right handed beta helix region; Region: Beta_helix; pfam13229 999891001102 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 999891001103 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 999891001104 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 999891001105 Spore germination protein; Region: Spore_permease; pfam03845 999891001106 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 999891001107 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 999891001108 active site 999891001109 non-prolyl cis peptide bond; other site 999891001110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891001111 Coenzyme A binding pocket [chemical binding]; other site 999891001112 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 999891001113 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999891001114 substrate binding pocket [chemical binding]; other site 999891001115 membrane-bound complex binding site; other site 999891001116 hinge residues; other site 999891001117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891001118 dimer interface [polypeptide binding]; other site 999891001119 conserved gate region; other site 999891001120 putative PBP binding loops; other site 999891001121 ABC-ATPase subunit interface; other site 999891001122 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 999891001123 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 999891001124 Walker A/P-loop; other site 999891001125 ATP binding site [chemical binding]; other site 999891001126 Q-loop/lid; other site 999891001127 ABC transporter signature motif; other site 999891001128 Walker B; other site 999891001129 D-loop; other site 999891001130 H-loop/switch region; other site 999891001131 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 999891001132 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 999891001133 metal binding site [ion binding]; metal-binding site 999891001134 dimer interface [polypeptide binding]; other site 999891001135 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 999891001136 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999891001137 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 999891001138 Walker A/P-loop; other site 999891001139 ATP binding site [chemical binding]; other site 999891001140 Q-loop/lid; other site 999891001141 ABC transporter signature motif; other site 999891001142 Walker B; other site 999891001143 D-loop; other site 999891001144 H-loop/switch region; other site 999891001145 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 999891001146 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 999891001147 FtsX-like permease family; Region: FtsX; pfam02687 999891001148 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999891001149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891001150 active site 999891001151 phosphorylation site [posttranslational modification] 999891001152 intermolecular recognition site; other site 999891001153 dimerization interface [polypeptide binding]; other site 999891001154 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999891001155 DNA binding site [nucleotide binding] 999891001156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999891001157 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 999891001158 dimerization interface [polypeptide binding]; other site 999891001159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891001160 dimer interface [polypeptide binding]; other site 999891001161 phosphorylation site [posttranslational modification] 999891001162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891001163 ATP binding site [chemical binding]; other site 999891001164 Mg2+ binding site [ion binding]; other site 999891001165 G-X-G motif; other site 999891001166 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 999891001167 binding surface 999891001168 TPR motif; other site 999891001169 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891001170 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891001171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891001172 TPR motif; other site 999891001173 binding surface 999891001174 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891001175 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 999891001176 aspartate kinase; Reviewed; Region: PRK09034 999891001177 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 999891001178 putative catalytic residues [active] 999891001179 putative nucleotide binding site [chemical binding]; other site 999891001180 putative aspartate binding site [chemical binding]; other site 999891001181 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 999891001182 allosteric regulatory residue; other site 999891001183 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 999891001184 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 999891001185 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 999891001186 ABC-ATPase subunit interface; other site 999891001187 dimer interface [polypeptide binding]; other site 999891001188 putative PBP binding regions; other site 999891001189 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 999891001190 ABC-ATPase subunit interface; other site 999891001191 dimer interface [polypeptide binding]; other site 999891001192 putative PBP binding regions; other site 999891001193 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 999891001194 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 999891001195 Walker A/P-loop; other site 999891001196 ATP binding site [chemical binding]; other site 999891001197 Q-loop/lid; other site 999891001198 ABC transporter signature motif; other site 999891001199 Walker B; other site 999891001200 D-loop; other site 999891001201 H-loop/switch region; other site 999891001202 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 999891001203 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 999891001204 putative ligand binding residues [chemical binding]; other site 999891001205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891001206 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891001207 putative substrate translocation pore; other site 999891001208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891001209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891001210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891001211 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 999891001212 dimer interface [polypeptide binding]; other site 999891001213 FMN binding site [chemical binding]; other site 999891001214 NADPH bind site [chemical binding]; other site 999891001215 Uncharacterized conserved protein [Function unknown]; Region: COG1359 999891001216 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891001217 dimerization interface [polypeptide binding]; other site 999891001218 putative DNA binding site [nucleotide binding]; other site 999891001219 putative Zn2+ binding site [ion binding]; other site 999891001220 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 999891001221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891001222 DNA-binding site [nucleotide binding]; DNA binding site 999891001223 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891001224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891001225 homodimer interface [polypeptide binding]; other site 999891001226 catalytic residue [active] 999891001227 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 999891001228 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 999891001229 inhibitor-cofactor binding pocket; inhibition site 999891001230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891001231 catalytic residue [active] 999891001232 succinic semialdehyde dehydrogenase; Region: PLN02278 999891001233 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 999891001234 tetramerization interface [polypeptide binding]; other site 999891001235 NAD(P) binding site [chemical binding]; other site 999891001236 catalytic residues [active] 999891001237 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 999891001238 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 999891001239 glucose-1-dehydrogenase; Provisional; Region: PRK08936 999891001240 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 999891001241 NAD binding site [chemical binding]; other site 999891001242 homodimer interface [polypeptide binding]; other site 999891001243 active site 999891001244 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 999891001245 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 999891001246 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 999891001247 YtkA-like; Region: YtkA; pfam13115 999891001248 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 999891001249 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 999891001250 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 999891001251 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 999891001252 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 999891001253 active site 999891001254 P-loop; other site 999891001255 phosphorylation site [posttranslational modification] 999891001256 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999891001257 active site 999891001258 phosphorylation site [posttranslational modification] 999891001259 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 999891001260 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 999891001261 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 999891001262 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 999891001263 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 999891001264 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891001265 active site 999891001266 motif I; other site 999891001267 motif II; other site 999891001268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891001269 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 999891001270 putative active site [active] 999891001271 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 999891001272 hypothetical protein; Provisional; Region: PRK05463 999891001273 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 999891001274 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 999891001275 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 999891001276 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 999891001277 Transcriptional regulator [Transcription]; Region: IclR; COG1414 999891001278 Bacterial transcriptional regulator; Region: IclR; pfam01614 999891001279 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 999891001280 active site 999891001281 catalytic triad [active] 999891001282 oxyanion hole [active] 999891001283 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 999891001284 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 999891001285 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 999891001286 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 999891001287 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 999891001288 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 999891001289 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999891001290 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999891001291 active site 999891001292 catalytic tetrad [active] 999891001293 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 999891001294 HTH domain; Region: HTH_11; pfam08279 999891001295 HTH domain; Region: HTH_11; cl17392 999891001296 PRD domain; Region: PRD; pfam00874 999891001297 PRD domain; Region: PRD; pfam00874 999891001298 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 999891001299 active site 999891001300 P-loop; other site 999891001301 phosphorylation site [posttranslational modification] 999891001302 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 999891001303 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 999891001304 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 999891001305 acyl-activating enzyme (AAE) consensus motif; other site 999891001306 putative AMP binding site [chemical binding]; other site 999891001307 putative active site [active] 999891001308 putative CoA binding site [chemical binding]; other site 999891001309 short chain dehydrogenase; Provisional; Region: PRK06701 999891001310 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 999891001311 NAD binding site [chemical binding]; other site 999891001312 metal binding site [ion binding]; metal-binding site 999891001313 active site 999891001314 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 999891001315 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 999891001316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 999891001317 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 999891001318 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 999891001319 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 999891001320 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 999891001321 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 999891001322 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 999891001323 putative DNA binding site [nucleotide binding]; other site 999891001324 putative Zn2+ binding site [ion binding]; other site 999891001325 AsnC family; Region: AsnC_trans_reg; pfam01037 999891001326 DNA topoisomerase III; Provisional; Region: PRK07726 999891001327 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 999891001328 active site 999891001329 putative interdomain interaction site [polypeptide binding]; other site 999891001330 putative metal-binding site [ion binding]; other site 999891001331 putative nucleotide binding site [chemical binding]; other site 999891001332 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 999891001333 domain I; other site 999891001334 DNA binding groove [nucleotide binding] 999891001335 phosphate binding site [ion binding]; other site 999891001336 domain II; other site 999891001337 domain III; other site 999891001338 nucleotide binding site [chemical binding]; other site 999891001339 catalytic site [active] 999891001340 domain IV; other site 999891001341 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 999891001342 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 999891001343 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 999891001344 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 999891001345 metal binding site [ion binding]; metal-binding site 999891001346 active site 999891001347 I-site; other site 999891001348 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 999891001349 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 999891001350 NodB motif; other site 999891001351 putative active site [active] 999891001352 putative catalytic site [active] 999891001353 putative Zn binding site [ion binding]; other site 999891001354 potential frameshift: common BLAST hit: gi|308172288|ref|YP_003918993.1| glycosyltransferase associated to biofilm formation 999891001355 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 999891001356 Amino acid permease; Region: AA_permease_2; pfam13520 999891001357 pyruvate oxidase; Provisional; Region: PRK08611 999891001358 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 999891001359 PYR/PP interface [polypeptide binding]; other site 999891001360 dimer interface [polypeptide binding]; other site 999891001361 tetramer interface [polypeptide binding]; other site 999891001362 TPP binding site [chemical binding]; other site 999891001363 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 999891001364 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 999891001365 TPP-binding site [chemical binding]; other site 999891001366 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 999891001367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891001368 Coenzyme A binding pocket [chemical binding]; other site 999891001369 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891001370 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 999891001371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 999891001372 binding surface 999891001373 TPR motif; other site 999891001374 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891001375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 999891001376 TPR motif; other site 999891001377 binding surface 999891001378 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891001379 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 999891001380 manganese transport protein MntH; Reviewed; Region: PRK00701 999891001381 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 999891001382 Bacterial SH3 domain; Region: SH3_3; cl17532 999891001383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 999891001384 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 999891001385 EcsC protein family; Region: EcsC; pfam12787 999891001386 General stress protein [General function prediction only]; Region: GsiB; COG3729 999891001387 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 999891001388 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 999891001389 dimanganese center [ion binding]; other site 999891001390 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 999891001391 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 999891001392 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 999891001393 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 999891001394 putative active site [active] 999891001395 heme pocket [chemical binding]; other site 999891001396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891001397 ATP binding site [chemical binding]; other site 999891001398 Mg2+ binding site [ion binding]; other site 999891001399 G-X-G motif; other site 999891001400 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 999891001401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891001402 active site 999891001403 phosphorylation site [posttranslational modification] 999891001404 intermolecular recognition site; other site 999891001405 dimerization interface [polypeptide binding]; other site 999891001406 HTH domain; Region: HTH_11; pfam08279 999891001407 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 999891001408 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 999891001409 Domain of unknown function DUF20; Region: UPF0118; pfam01594 999891001410 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 999891001411 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 999891001412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891001413 Walker A/P-loop; other site 999891001414 ATP binding site [chemical binding]; other site 999891001415 Q-loop/lid; other site 999891001416 ABC transporter signature motif; other site 999891001417 Walker B; other site 999891001418 D-loop; other site 999891001419 H-loop/switch region; other site 999891001420 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 999891001421 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 999891001422 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 999891001423 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 999891001424 active site 999891001425 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 999891001426 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 999891001427 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 999891001428 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 999891001429 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 999891001430 catalytic residues [active] 999891001431 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 999891001432 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 999891001433 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 999891001434 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 999891001435 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 999891001436 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 999891001437 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 999891001438 helicase 45; Provisional; Region: PTZ00424 999891001439 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 999891001440 ATP binding site [chemical binding]; other site 999891001441 Mg++ binding site [ion binding]; other site 999891001442 motif III; other site 999891001443 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999891001444 nucleotide binding region [chemical binding]; other site 999891001445 ATP-binding site [chemical binding]; other site 999891001446 Uncharacterized conserved protein [Function unknown]; Region: COG3402 999891001447 Predicted membrane protein [Function unknown]; Region: COG3428 999891001448 Bacterial PH domain; Region: DUF304; pfam03703 999891001449 Bacterial PH domain; Region: DUF304; pfam03703 999891001450 Bacterial PH domain; Region: DUF304; pfam03703 999891001451 Rhomboid family; Region: Rhomboid; pfam01694 999891001452 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 999891001453 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 999891001454 alanine racemase; Region: alr; TIGR00492 999891001455 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 999891001456 active site 999891001457 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 999891001458 dimer interface [polypeptide binding]; other site 999891001459 substrate binding site [chemical binding]; other site 999891001460 catalytic residues [active] 999891001461 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 999891001462 ribbon-helix-helix domain containing protein; Region: PHA00617 999891001463 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 999891001464 Rsbr N terminal; Region: Rsbr_N; pfam08678 999891001465 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 999891001466 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 999891001467 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 999891001468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891001469 ATP binding site [chemical binding]; other site 999891001470 Mg2+ binding site [ion binding]; other site 999891001471 G-X-G motif; other site 999891001472 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 999891001473 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 999891001474 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 999891001475 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 999891001476 anti sigma factor interaction site; other site 999891001477 regulatory phosphorylation site [posttranslational modification]; other site 999891001478 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 999891001479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891001480 ATP binding site [chemical binding]; other site 999891001481 Mg2+ binding site [ion binding]; other site 999891001482 G-X-G motif; other site 999891001483 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 999891001484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999891001485 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 999891001486 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999891001487 DNA binding residues [nucleotide binding] 999891001488 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 999891001489 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 999891001490 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 999891001491 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 999891001492 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 999891001493 RNA binding site [nucleotide binding]; other site 999891001494 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 999891001495 hypothetical protein; Provisional; Region: PRK04351 999891001496 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 999891001497 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 999891001498 substrate binding pocket [chemical binding]; other site 999891001499 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 999891001500 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 999891001501 Transcriptional regulators [Transcription]; Region: MarR; COG1846 999891001502 MarR family; Region: MarR; pfam01047 999891001503 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 999891001504 Transcriptional regulators [Transcription]; Region: MarR; COG1846 999891001505 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891001506 dimerization interface [polypeptide binding]; other site 999891001507 putative Zn2+ binding site [ion binding]; other site 999891001508 putative DNA binding site [nucleotide binding]; other site 999891001509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891001510 Coenzyme A binding pocket [chemical binding]; other site 999891001511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891001512 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891001513 putative substrate translocation pore; other site 999891001514 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 999891001515 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 999891001516 Predicted transcriptional regulator [Transcription]; Region: COG1959 999891001517 Transcriptional regulator; Region: Rrf2; pfam02082 999891001518 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 999891001519 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 999891001520 DNA-binding site [nucleotide binding]; DNA binding site 999891001521 RNA-binding motif; other site 999891001522 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 999891001523 aspartate racemase; Region: asp_race; TIGR00035 999891001524 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 999891001525 Predicted transcriptional regulators [Transcription]; Region: COG1695 999891001526 Transcriptional regulator PadR-like family; Region: PadR; cl17335 999891001527 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 999891001528 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891001529 DNA-binding site [nucleotide binding]; DNA binding site 999891001530 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891001531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891001532 homodimer interface [polypeptide binding]; other site 999891001533 catalytic residue [active] 999891001534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891001535 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891001536 putative substrate translocation pore; other site 999891001537 Patatin [General function prediction only]; Region: COG3621 999891001538 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 999891001539 active site 999891001540 nucleophile elbow; other site 999891001541 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 999891001542 FAD binding domain; Region: FAD_binding_4; pfam01565 999891001543 Berberine and berberine like; Region: BBE; pfam08031 999891001544 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 999891001545 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 999891001546 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 999891001547 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 999891001548 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 999891001549 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 999891001550 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 999891001551 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 999891001552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891001553 Coenzyme A binding pocket [chemical binding]; other site 999891001554 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 999891001555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 999891001556 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 999891001557 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 999891001558 FeS/SAM binding site; other site 999891001559 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 999891001560 Sodium Bile acid symporter family; Region: SBF; cl17470 999891001561 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 999891001562 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 999891001563 putative NAD(P) binding site [chemical binding]; other site 999891001564 putative substrate binding site [chemical binding]; other site 999891001565 catalytic Zn binding site [ion binding]; other site 999891001566 structural Zn binding site [ion binding]; other site 999891001567 dimer interface [polypeptide binding]; other site 999891001568 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 999891001569 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 999891001570 DNA binding residues [nucleotide binding] 999891001571 putative dimer interface [polypeptide binding]; other site 999891001572 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 999891001573 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 999891001574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891001575 DNA-binding site [nucleotide binding]; DNA binding site 999891001576 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891001577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891001578 homodimer interface [polypeptide binding]; other site 999891001579 catalytic residue [active] 999891001580 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 999891001581 benzoate transport; Region: 2A0115; TIGR00895 999891001582 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891001583 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891001584 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 999891001585 EamA-like transporter family; Region: EamA; cl17759 999891001586 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 999891001587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891001588 DNA-binding site [nucleotide binding]; DNA binding site 999891001589 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891001590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891001591 homodimer interface [polypeptide binding]; other site 999891001592 catalytic residue [active] 999891001593 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 999891001594 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 999891001595 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 999891001596 NAD binding site [chemical binding]; other site 999891001597 catalytic Zn binding site [ion binding]; other site 999891001598 structural Zn binding site [ion binding]; other site 999891001599 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 999891001600 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 999891001601 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 999891001602 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 999891001603 catalytic triad [active] 999891001604 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 999891001605 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999891001606 ABC transporter; Region: ABC_tran_2; pfam12848 999891001607 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999891001608 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 999891001609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891001610 Coenzyme A binding pocket [chemical binding]; other site 999891001611 Uncharacterized conserved protein [Function unknown]; Region: COG1284 999891001612 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999891001613 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999891001614 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 999891001615 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 999891001616 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 999891001617 dimer interface [polypeptide binding]; other site 999891001618 active site 999891001619 metal binding site [ion binding]; metal-binding site 999891001620 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 999891001621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891001622 putative substrate translocation pore; other site 999891001623 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 999891001624 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 999891001625 dimer interface [polypeptide binding]; other site 999891001626 active site 999891001627 Helix-turn-helix domain; Region: HTH_31; pfam13560 999891001628 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 999891001629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891001630 Coenzyme A binding pocket [chemical binding]; other site 999891001631 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 999891001632 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 999891001633 DNA binding residues [nucleotide binding] 999891001634 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 999891001635 EamA-like transporter family; Region: EamA; pfam00892 999891001636 EamA-like transporter family; Region: EamA; pfam00892 999891001637 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 999891001638 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 999891001639 nudix motif; other site 999891001640 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 999891001641 Epoxide hydrolase N terminus; Region: EHN; pfam06441 999891001642 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 999891001643 tartrate dehydrogenase; Provisional; Region: PRK08194 999891001644 Transcriptional regulators [Transcription]; Region: GntR; COG1802 999891001645 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891001646 DNA-binding site [nucleotide binding]; DNA binding site 999891001647 FCD domain; Region: FCD; pfam07729 999891001648 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 999891001649 glycosyltransferase, MGT family; Region: MGT; TIGR01426 999891001650 active site 999891001651 TDP-binding site; other site 999891001652 acceptor substrate-binding pocket; other site 999891001653 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 999891001654 Beta-lactamase; Region: Beta-lactamase; pfam00144 999891001655 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 999891001656 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 999891001657 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 999891001658 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 999891001659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891001660 putative substrate translocation pore; other site 999891001661 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 999891001662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891001663 DNA-binding site [nucleotide binding]; DNA binding site 999891001664 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 999891001665 Transcriptional regulators [Transcription]; Region: FadR; COG2186 999891001666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891001667 DNA-binding site [nucleotide binding]; DNA binding site 999891001668 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 999891001669 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 999891001670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891001671 putative substrate translocation pore; other site 999891001672 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 999891001673 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 999891001674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891001675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891001676 amino acid transporter; Region: 2A0306; TIGR00909 999891001677 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 999891001678 dimanganese center [ion binding]; other site 999891001679 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 999891001680 putative hydrophobic ligand binding site [chemical binding]; other site 999891001681 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 999891001682 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 999891001683 putative NADP binding site [chemical binding]; other site 999891001684 putative dimer interface [polypeptide binding]; other site 999891001685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891001686 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 999891001687 putative substrate translocation pore; other site 999891001688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891001689 thiamine monophosphate kinase; Provisional; Region: PRK05731 999891001690 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 999891001691 ATP binding site [chemical binding]; other site 999891001692 dimerization interface [polypeptide binding]; other site 999891001693 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 999891001694 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 999891001695 Glycoprotease family; Region: Peptidase_M22; pfam00814 999891001696 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 999891001697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891001698 Coenzyme A binding pocket [chemical binding]; other site 999891001699 UGMP family protein; Validated; Region: PRK09604 999891001700 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 999891001701 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 999891001702 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 999891001703 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999891001704 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999891001705 ABC transporter; Region: ABC_tran_2; pfam12848 999891001706 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999891001707 ABC transporter; Region: ABC_tran_2; pfam12848 999891001708 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 999891001709 trimer interface [polypeptide binding]; other site 999891001710 dimer interface [polypeptide binding]; other site 999891001711 putative active site [active] 999891001712 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 999891001713 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 999891001714 CoA binding domain; Region: CoA_binding; pfam02629 999891001715 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 999891001716 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 999891001717 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 999891001718 CAAX protease self-immunity; Region: Abi; pfam02517 999891001719 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 999891001720 oligomerisation interface [polypeptide binding]; other site 999891001721 mobile loop; other site 999891001722 roof hairpin; other site 999891001723 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 999891001724 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 999891001725 ring oligomerisation interface [polypeptide binding]; other site 999891001726 ATP/Mg binding site [chemical binding]; other site 999891001727 stacking interactions; other site 999891001728 hinge regions; other site 999891001729 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 999891001730 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 999891001731 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 999891001732 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 999891001733 active site 999891001734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891001735 Walker A motif; other site 999891001736 ATP binding site [chemical binding]; other site 999891001737 Walker B motif; other site 999891001738 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891001739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891001740 binding surface 999891001741 TPR motif; other site 999891001742 TPR repeat; Region: TPR_11; pfam13414 999891001743 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 999891001744 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 999891001745 inhibitor binding site; inhibition site 999891001746 catalytic Zn binding site [ion binding]; other site 999891001747 structural Zn binding site [ion binding]; other site 999891001748 NADP binding site [chemical binding]; other site 999891001749 tetramer interface [polypeptide binding]; other site 999891001750 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 999891001751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891001752 putative substrate translocation pore; other site 999891001753 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 999891001754 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 999891001755 putative substrate binding site [chemical binding]; other site 999891001756 putative ATP binding site [chemical binding]; other site 999891001757 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 999891001758 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 999891001759 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 999891001760 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 999891001761 Repair protein; Region: Repair_PSII; pfam04536 999891001762 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 999891001763 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 999891001764 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 999891001765 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 999891001766 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 999891001767 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 999891001768 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 999891001769 catalytic triad [active] 999891001770 catalytic triad [active] 999891001771 oxyanion hole [active] 999891001772 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 999891001773 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 999891001774 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 999891001775 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999891001776 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999891001777 DNA binding residues [nucleotide binding] 999891001778 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 999891001779 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 999891001780 putative NAD(P) binding site [chemical binding]; other site 999891001781 catalytic Zn binding site [ion binding]; other site 999891001782 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 999891001783 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 999891001784 Cold-inducible protein YdjO; Region: YdjO; pfam14169 999891001785 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 999891001786 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 999891001787 Multicopper oxidase; Region: Cu-oxidase; pfam00394 999891001788 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 999891001789 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 999891001790 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 999891001791 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 999891001792 MoxR-like ATPases [General function prediction only]; Region: COG0714 999891001793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891001794 Walker A motif; other site 999891001795 ATP binding site [chemical binding]; other site 999891001796 Walker B motif; other site 999891001797 arginine finger; other site 999891001798 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 999891001799 Protein of unknown function DUF58; Region: DUF58; pfam01882 999891001800 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 999891001801 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 999891001802 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 999891001803 GMP synthase; Reviewed; Region: guaA; PRK00074 999891001804 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 999891001805 AMP/PPi binding site [chemical binding]; other site 999891001806 candidate oxyanion hole; other site 999891001807 catalytic triad [active] 999891001808 potential glutamine specificity residues [chemical binding]; other site 999891001809 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 999891001810 ATP Binding subdomain [chemical binding]; other site 999891001811 Ligand Binding sites [chemical binding]; other site 999891001812 Dimerization subdomain; other site 999891001813 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 999891001814 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999891001815 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999891001816 DNA binding residues [nucleotide binding] 999891001817 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 999891001818 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 999891001819 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 999891001820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 999891001821 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 999891001822 NETI protein; Region: NETI; pfam14044 999891001823 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 999891001824 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 999891001825 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 999891001826 NAD binding site [chemical binding]; other site 999891001827 ATP-grasp domain; Region: ATP-grasp; pfam02222 999891001828 adenylosuccinate lyase; Provisional; Region: PRK07492 999891001829 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 999891001830 tetramer interface [polypeptide binding]; other site 999891001831 active site 999891001832 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 999891001833 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 999891001834 ATP binding site [chemical binding]; other site 999891001835 active site 999891001836 substrate binding site [chemical binding]; other site 999891001837 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 999891001838 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 999891001839 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 999891001840 putative active site [active] 999891001841 catalytic triad [active] 999891001842 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 999891001843 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 999891001844 dimerization interface [polypeptide binding]; other site 999891001845 ATP binding site [chemical binding]; other site 999891001846 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 999891001847 dimerization interface [polypeptide binding]; other site 999891001848 ATP binding site [chemical binding]; other site 999891001849 amidophosphoribosyltransferase; Provisional; Region: PRK07631 999891001850 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 999891001851 active site 999891001852 tetramer interface [polypeptide binding]; other site 999891001853 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999891001854 active site 999891001855 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 999891001856 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 999891001857 dimerization interface [polypeptide binding]; other site 999891001858 putative ATP binding site [chemical binding]; other site 999891001859 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 999891001860 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 999891001861 active site 999891001862 substrate binding site [chemical binding]; other site 999891001863 cosubstrate binding site; other site 999891001864 catalytic site [active] 999891001865 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 999891001866 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 999891001867 purine monophosphate binding site [chemical binding]; other site 999891001868 dimer interface [polypeptide binding]; other site 999891001869 putative catalytic residues [active] 999891001870 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 999891001871 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 999891001872 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 999891001873 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 999891001874 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 999891001875 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 999891001876 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 999891001877 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891001878 putative DNA binding site [nucleotide binding]; other site 999891001879 putative Zn2+ binding site [ion binding]; other site 999891001880 AsnC family; Region: AsnC_trans_reg; pfam01037 999891001881 putative transporter; Provisional; Region: PRK11021 999891001882 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 999891001883 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 999891001884 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 999891001885 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 999891001886 active site 999891001887 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 999891001888 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 999891001889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 999891001890 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 999891001891 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 999891001892 active site 999891001893 FMN binding site [chemical binding]; other site 999891001894 substrate binding site [chemical binding]; other site 999891001895 3Fe-4S cluster binding site [ion binding]; other site 999891001896 PcrB family; Region: PcrB; pfam01884 999891001897 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 999891001898 substrate binding site [chemical binding]; other site 999891001899 putative active site [active] 999891001900 dimer interface [polypeptide binding]; other site 999891001901 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 999891001902 Part of AAA domain; Region: AAA_19; pfam13245 999891001903 Family description; Region: UvrD_C_2; pfam13538 999891001904 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 999891001905 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 999891001906 nucleotide binding pocket [chemical binding]; other site 999891001907 K-X-D-G motif; other site 999891001908 catalytic site [active] 999891001909 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 999891001910 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 999891001911 Helix-hairpin-helix motif; Region: HHH; pfam00633 999891001912 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 999891001913 Dimer interface [polypeptide binding]; other site 999891001914 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 999891001915 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 999891001916 putative dimer interface [polypeptide binding]; other site 999891001917 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 999891001918 putative dimer interface [polypeptide binding]; other site 999891001919 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 999891001920 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 999891001921 active site 999891001922 ATP binding site [chemical binding]; other site 999891001923 substrate binding site [chemical binding]; other site 999891001924 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 999891001925 MgtC family; Region: MgtC; pfam02308 999891001926 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 999891001927 Na binding site [ion binding]; other site 999891001928 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 999891001929 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 999891001930 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 999891001931 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 999891001932 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 999891001933 GatB domain; Region: GatB_Yqey; pfam02637 999891001934 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891001935 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891001936 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 999891001937 Protein export membrane protein; Region: SecD_SecF; cl14618 999891001938 putative lipid kinase; Reviewed; Region: PRK13337 999891001939 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 999891001940 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 999891001941 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 999891001942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891001943 S-adenosylmethionine binding site [chemical binding]; other site 999891001944 Part of AAA domain; Region: AAA_19; pfam13245 999891001945 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 999891001946 Uncharacterized conserved protein [Function unknown]; Region: COG3410 999891001947 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 999891001948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891001949 Walker A/P-loop; other site 999891001950 ATP binding site [chemical binding]; other site 999891001951 Q-loop/lid; other site 999891001952 ABC transporter signature motif; other site 999891001953 Walker B; other site 999891001954 D-loop; other site 999891001955 H-loop/switch region; other site 999891001956 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 999891001957 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 999891001958 LXG domain of WXG superfamily; Region: LXG; pfam04740 999891001959 hypothetical protein; Provisional; Region: PRK12378 999891001960 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 999891001961 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 999891001962 CotJB protein; Region: CotJB; pfam12652 999891001963 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 999891001964 dimanganese center [ion binding]; other site 999891001965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891001966 Coenzyme A binding pocket [chemical binding]; other site 999891001967 YesK-like protein; Region: YesK; pfam14150 999891001968 Predicted membrane protein [Function unknown]; Region: COG2323 999891001969 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 999891001970 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 999891001971 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 999891001972 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 999891001973 Uncharacterized small protein [Function unknown]; Region: COG5583 999891001974 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 999891001975 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 999891001976 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891001977 MarR family; Region: MarR; pfam01047 999891001978 hypothetical protein; Provisional; Region: PRK06847 999891001979 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 999891001980 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 999891001981 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 999891001982 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 999891001983 Cytochrome P450; Region: p450; pfam00067 999891001984 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 999891001985 Flavodoxin; Region: Flavodoxin_1; pfam00258 999891001986 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 999891001987 FAD binding pocket [chemical binding]; other site 999891001988 FAD binding motif [chemical binding]; other site 999891001989 catalytic residues [active] 999891001990 NAD binding pocket [chemical binding]; other site 999891001991 phosphate binding motif [ion binding]; other site 999891001992 beta-alpha-beta structure motif; other site 999891001993 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 999891001994 Sulfatase; Region: Sulfatase; pfam00884 999891001995 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 999891001996 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 999891001997 substrate binding site; other site 999891001998 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 999891001999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999891002000 NAD(P) binding site [chemical binding]; other site 999891002001 active site 999891002002 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 999891002003 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 999891002004 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 999891002005 active site 999891002006 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 999891002007 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 999891002008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891002009 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891002010 putative substrate translocation pore; other site 999891002011 amino acid transporter; Region: 2A0306; TIGR00909 999891002012 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 999891002013 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 999891002014 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 999891002015 NAD(P) binding site [chemical binding]; other site 999891002016 catalytic residues [active] 999891002017 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 999891002018 dimer interface [polypeptide binding]; other site 999891002019 putative CheW interface [polypeptide binding]; other site 999891002020 oxidoreductase; Provisional; Region: PRK07985 999891002021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999891002022 NAD(P) binding site [chemical binding]; other site 999891002023 active site 999891002024 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 999891002025 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 999891002026 putative metal binding site; other site 999891002027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 999891002028 binding surface 999891002029 TPR motif; other site 999891002030 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 999891002031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891002032 Walker A/P-loop; other site 999891002033 ATP binding site [chemical binding]; other site 999891002034 Q-loop/lid; other site 999891002035 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999891002036 ABC transporter signature motif; other site 999891002037 Walker B; other site 999891002038 D-loop; other site 999891002039 ABC transporter; Region: ABC_tran_2; pfam12848 999891002040 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999891002041 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 999891002042 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 999891002043 DNA binding residues [nucleotide binding] 999891002044 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 999891002045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891002046 putative substrate translocation pore; other site 999891002047 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 999891002048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891002049 Walker A/P-loop; other site 999891002050 ATP binding site [chemical binding]; other site 999891002051 Q-loop/lid; other site 999891002052 ABC transporter signature motif; other site 999891002053 Walker B; other site 999891002054 D-loop; other site 999891002055 H-loop/switch region; other site 999891002056 ABC transporter; Region: ABC_tran_2; pfam12848 999891002057 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999891002058 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 999891002059 DEAD-like helicases superfamily; Region: DEXDc; smart00487 999891002060 ATP binding site [chemical binding]; other site 999891002061 Mg++ binding site [ion binding]; other site 999891002062 motif III; other site 999891002063 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999891002064 nucleotide binding region [chemical binding]; other site 999891002065 ATP-binding site [chemical binding]; other site 999891002066 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 999891002067 Prostaglandin dehydrogenases; Region: PGDH; cd05288 999891002068 NAD(P) binding site [chemical binding]; other site 999891002069 substrate binding site [chemical binding]; other site 999891002070 dimer interface [polypeptide binding]; other site 999891002071 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 999891002072 Heat induced stress protein YflT; Region: YflT; pfam11181 999891002073 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 999891002074 Amb_all domain; Region: Amb_all; smart00656 999891002075 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 999891002076 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 999891002077 transmembrane helices; other site 999891002078 BclB C-terminal domain; Region: exospore_TM; TIGR03721 999891002079 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 999891002080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999891002081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891002082 dimer interface [polypeptide binding]; other site 999891002083 phosphorylation site [posttranslational modification] 999891002084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891002085 ATP binding site [chemical binding]; other site 999891002086 Mg2+ binding site [ion binding]; other site 999891002087 G-X-G motif; other site 999891002088 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 999891002089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891002090 active site 999891002091 phosphorylation site [posttranslational modification] 999891002092 intermolecular recognition site; other site 999891002093 dimerization interface [polypeptide binding]; other site 999891002094 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 999891002095 Histidine kinase; Region: His_kinase; pfam06580 999891002096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891002097 ATP binding site [chemical binding]; other site 999891002098 Mg2+ binding site [ion binding]; other site 999891002099 G-X-G motif; other site 999891002100 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 999891002101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891002102 active site 999891002103 phosphorylation site [posttranslational modification] 999891002104 intermolecular recognition site; other site 999891002105 dimerization interface [polypeptide binding]; other site 999891002106 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 999891002107 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 999891002108 Collagen binding domain; Region: Collagen_bind; pfam05737 999891002109 Collagen binding domain; Region: Collagen_bind; pfam05737 999891002110 Collagen binding domain; Region: Collagen_bind; pfam05737 999891002111 Cna protein B-type domain; Region: Cna_B; pfam05738 999891002112 Cna protein B-type domain; Region: Cna_B; pfam05738 999891002113 Cna protein B-type domain; Region: Cna_B; pfam05738 999891002114 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 999891002115 Cna protein B-type domain; Region: Cna_B; pfam05738 999891002116 Cna protein B-type domain; Region: Cna_B; pfam05738 999891002117 Cna protein B-type domain; Region: Cna_B; pfam05738 999891002118 Cna protein B-type domain; Region: Cna_B; pfam05738 999891002119 Cna protein B-type domain; Region: Cna_B; pfam05738 999891002120 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 999891002121 active site 999891002122 catalytic site [active] 999891002123 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 999891002124 PAS domain; Region: PAS; smart00091 999891002125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891002126 ATP binding site [chemical binding]; other site 999891002127 Mg2+ binding site [ion binding]; other site 999891002128 G-X-G motif; other site 999891002129 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 999891002130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891002131 active site 999891002132 phosphorylation site [posttranslational modification] 999891002133 intermolecular recognition site; other site 999891002134 dimerization interface [polypeptide binding]; other site 999891002135 Transcriptional regulator; Region: CitT; pfam12431 999891002136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 999891002137 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 999891002138 Citrate transporter; Region: CitMHS; pfam03600 999891002139 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 999891002140 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 999891002141 active site 999891002142 dimer interface [polypeptide binding]; other site 999891002143 Acylphosphatase; Region: Acylphosphatase; cl00551 999891002144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 999891002145 MOSC domain; Region: MOSC; pfam03473 999891002146 3-alpha domain; Region: 3-alpha; pfam03475 999891002147 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 999891002148 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 999891002149 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 999891002150 active site 999891002151 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 999891002152 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 999891002153 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 999891002154 active site turn [active] 999891002155 phosphorylation site [posttranslational modification] 999891002156 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 999891002157 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 999891002158 Sulfatase; Region: Sulfatase; pfam00884 999891002159 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 999891002160 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 999891002161 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 999891002162 putative dimer interface [polypeptide binding]; other site 999891002163 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 999891002164 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 999891002165 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 999891002166 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 999891002167 active site turn [active] 999891002168 phosphorylation site [posttranslational modification] 999891002169 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 999891002170 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 999891002171 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 999891002172 Ca binding site [ion binding]; other site 999891002173 active site 999891002174 catalytic site [active] 999891002175 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 999891002176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891002177 DNA-binding site [nucleotide binding]; DNA binding site 999891002178 UTRA domain; Region: UTRA; pfam07702 999891002179 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 999891002180 dimer interface [polypeptide binding]; other site 999891002181 FMN binding site [chemical binding]; other site 999891002182 YibE/F-like protein; Region: YibE_F; pfam07907 999891002183 YibE/F-like protein; Region: YibE_F; pfam07907 999891002184 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 999891002185 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 999891002186 active site 999891002187 metal binding site [ion binding]; metal-binding site 999891002188 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 999891002189 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 999891002190 active site 999891002191 metal binding site [ion binding]; metal-binding site 999891002192 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 999891002193 intracellular protease, PfpI family; Region: PfpI; TIGR01382 999891002194 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 999891002195 proposed catalytic triad [active] 999891002196 conserved cys residue [active] 999891002197 Transcriptional regulators [Transcription]; Region: PurR; COG1609 999891002198 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999891002199 DNA binding site [nucleotide binding] 999891002200 domain linker motif; other site 999891002201 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 999891002202 putative dimerization interface [polypeptide binding]; other site 999891002203 putative ligand binding site [chemical binding]; other site 999891002204 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 999891002205 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 999891002206 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 999891002207 shikimate binding site; other site 999891002208 NAD(P) binding site [chemical binding]; other site 999891002209 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 999891002210 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 999891002211 active site 999891002212 catalytic residue [active] 999891002213 dimer interface [polypeptide binding]; other site 999891002214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891002215 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891002216 putative substrate translocation pore; other site 999891002217 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 999891002218 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 999891002219 Low molecular weight phosphatase family; Region: LMWPc; cd00115 999891002220 active site 999891002221 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 999891002222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891002223 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891002224 putative substrate translocation pore; other site 999891002225 calcium/proton exchanger (cax); Region: cax; TIGR00378 999891002226 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 999891002227 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 999891002228 YfkD-like protein; Region: YfkD; pfam14167 999891002229 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 999891002230 Mechanosensitive ion channel; Region: MS_channel; pfam00924 999891002231 Radical SAM superfamily; Region: Radical_SAM; pfam04055 999891002232 YfkB-like domain; Region: YfkB; pfam08756 999891002233 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 999891002234 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 999891002235 NodB motif; other site 999891002236 active site 999891002237 catalytic site [active] 999891002238 Cd binding site [ion binding]; other site 999891002239 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 999891002240 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 999891002241 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 999891002242 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 999891002243 oligomer interface [polypeptide binding]; other site 999891002244 metal binding site [ion binding]; metal-binding site 999891002245 metal binding site [ion binding]; metal-binding site 999891002246 putative Cl binding site [ion binding]; other site 999891002247 aspartate ring; other site 999891002248 basic sphincter; other site 999891002249 hydrophobic gate; other site 999891002250 periplasmic entrance; other site 999891002251 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 999891002252 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 999891002253 minor groove reading motif; other site 999891002254 helix-hairpin-helix signature motif; other site 999891002255 substrate binding pocket [chemical binding]; other site 999891002256 active site 999891002257 TRAM domain; Region: TRAM; pfam01938 999891002258 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 999891002259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891002260 S-adenosylmethionine binding site [chemical binding]; other site 999891002261 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 999891002262 active site 999891002263 catalytic residues [active] 999891002264 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999891002265 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999891002266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891002267 Walker A/P-loop; other site 999891002268 ATP binding site [chemical binding]; other site 999891002269 Q-loop/lid; other site 999891002270 ABC transporter signature motif; other site 999891002271 Walker B; other site 999891002272 D-loop; other site 999891002273 H-loop/switch region; other site 999891002274 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 999891002275 active site 999891002276 ATP binding site [chemical binding]; other site 999891002277 substrate binding site [chemical binding]; other site 999891002278 activation loop (A-loop); other site 999891002279 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 999891002280 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 999891002281 active site 999891002282 zinc binding site [ion binding]; other site 999891002283 YfzA-like protein; Region: YfzA; pfam14118 999891002284 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 999891002285 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 999891002286 FMN binding site [chemical binding]; other site 999891002287 active site 999891002288 catalytic residues [active] 999891002289 substrate binding site [chemical binding]; other site 999891002290 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 999891002291 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 999891002292 tetramer interface [polypeptide binding]; other site 999891002293 TPP-binding site [chemical binding]; other site 999891002294 heterodimer interface [polypeptide binding]; other site 999891002295 phosphorylation loop region [posttranslational modification] 999891002296 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 999891002297 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 999891002298 alpha subunit interface [polypeptide binding]; other site 999891002299 TPP binding site [chemical binding]; other site 999891002300 heterodimer interface [polypeptide binding]; other site 999891002301 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 999891002302 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 999891002303 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 999891002304 E3 interaction surface; other site 999891002305 lipoyl attachment site [posttranslational modification]; other site 999891002306 e3 binding domain; Region: E3_binding; pfam02817 999891002307 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 999891002308 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 999891002309 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999891002310 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 999891002311 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 999891002312 GAF domain; Region: GAF; pfam01590 999891002313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891002314 Walker A motif; other site 999891002315 ATP binding site [chemical binding]; other site 999891002316 Walker B motif; other site 999891002317 arginine finger; other site 999891002318 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 999891002319 Small acid-soluble spore protein H family; Region: SspH; pfam08141 999891002320 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 999891002321 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 999891002322 NAD binding site [chemical binding]; other site 999891002323 sugar binding site [chemical binding]; other site 999891002324 divalent metal binding site [ion binding]; other site 999891002325 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 999891002326 dimer interface [polypeptide binding]; other site 999891002327 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 999891002328 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 999891002329 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 999891002330 putative active site [active] 999891002331 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 999891002332 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 999891002333 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 999891002334 active site turn [active] 999891002335 phosphorylation site [posttranslational modification] 999891002336 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 999891002337 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 999891002338 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 999891002339 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999891002340 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999891002341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891002342 Walker A/P-loop; other site 999891002343 ATP binding site [chemical binding]; other site 999891002344 Q-loop/lid; other site 999891002345 ABC transporter signature motif; other site 999891002346 Walker B; other site 999891002347 D-loop; other site 999891002348 H-loop/switch region; other site 999891002349 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999891002350 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999891002351 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 999891002352 Walker A/P-loop; other site 999891002353 ATP binding site [chemical binding]; other site 999891002354 Q-loop/lid; other site 999891002355 ABC transporter signature motif; other site 999891002356 Walker B; other site 999891002357 D-loop; other site 999891002358 H-loop/switch region; other site 999891002359 Predicted membrane protein [Function unknown]; Region: COG2259 999891002360 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 999891002361 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 999891002362 putative metal binding site [ion binding]; other site 999891002363 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 999891002364 active site 999891002365 Predicted transcriptional regulators [Transcription]; Region: COG1695 999891002366 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 999891002367 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 999891002368 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 999891002369 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 999891002370 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 999891002371 Acyltransferase family; Region: Acyl_transf_3; pfam01757 999891002372 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 999891002373 RNAase interaction site [polypeptide binding]; other site 999891002374 metal-dependent hydrolase; Provisional; Region: PRK13291 999891002375 DinB superfamily; Region: DinB_2; pfam12867 999891002376 benzoate transport; Region: 2A0115; TIGR00895 999891002377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891002378 putative substrate translocation pore; other site 999891002379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891002380 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891002381 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891002382 putative Zn2+ binding site [ion binding]; other site 999891002383 putative DNA binding site [nucleotide binding]; other site 999891002384 Predicted integral membrane protein [Function unknown]; Region: COG0392 999891002385 Uncharacterized conserved protein [Function unknown]; Region: COG2898 999891002386 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 999891002387 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 999891002388 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 999891002389 putative FMN binding site [chemical binding]; other site 999891002390 YfhD-like protein; Region: YfhD; pfam14151 999891002391 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 999891002392 TIGR01777 family protein; Region: yfcH 999891002393 putative NAD(P) binding site [chemical binding]; other site 999891002394 putative active site [active] 999891002395 recombination regulator RecX; Provisional; Region: recX; PRK14135 999891002396 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 999891002397 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 999891002398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891002399 putative substrate translocation pore; other site 999891002400 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 999891002401 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 999891002402 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 999891002403 WVELL protein; Region: WVELL; pfam14043 999891002404 Bacterial SH3 domain; Region: SH3_3; pfam08239 999891002405 Bacterial SH3 domain; Region: SH3_3; cl17532 999891002406 SdpI/YhfL protein family; Region: SdpI; pfam13630 999891002407 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 999891002408 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 999891002409 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 999891002410 Ligand binding site; other site 999891002411 Putative Catalytic site; other site 999891002412 DXD motif; other site 999891002413 Predicted membrane protein [Function unknown]; Region: COG4485 999891002414 Caenorhabditis protein of unknown function, DUF267; Region: DUF267; pfam03268 999891002415 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 999891002416 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 999891002417 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 999891002418 minor groove reading motif; other site 999891002419 helix-hairpin-helix signature motif; other site 999891002420 substrate binding pocket [chemical binding]; other site 999891002421 active site 999891002422 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 999891002423 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 999891002424 DNA binding and oxoG recognition site [nucleotide binding] 999891002425 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 999891002426 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 999891002427 putative NAD(P) binding site [chemical binding]; other site 999891002428 active site 999891002429 YgaB-like protein; Region: YgaB; pfam14182 999891002430 hypothetical protein; Provisional; Region: PRK13662 999891002431 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999891002432 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999891002433 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 999891002434 Walker A/P-loop; other site 999891002435 ATP binding site [chemical binding]; other site 999891002436 Q-loop/lid; other site 999891002437 ABC transporter signature motif; other site 999891002438 Walker B; other site 999891002439 D-loop; other site 999891002440 H-loop/switch region; other site 999891002441 Predicted membrane protein [Function unknown]; Region: COG4129 999891002442 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 999891002443 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 999891002444 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 999891002445 inhibitor-cofactor binding pocket; inhibition site 999891002446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891002447 catalytic residue [active] 999891002448 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 999891002449 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 999891002450 catalytic triad [active] 999891002451 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 999891002452 metal binding site 2 [ion binding]; metal-binding site 999891002453 putative DNA binding helix; other site 999891002454 metal binding site 1 [ion binding]; metal-binding site 999891002455 dimer interface [polypeptide binding]; other site 999891002456 structural Zn2+ binding site [ion binding]; other site 999891002457 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 999891002458 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 999891002459 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 999891002460 active site pocket [active] 999891002461 oxyanion hole [active] 999891002462 catalytic triad [active] 999891002463 active site nucleophile [active] 999891002464 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 999891002465 ThiC-associated domain; Region: ThiC-associated; pfam13667 999891002466 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 999891002467 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 999891002468 FAD binding domain; Region: FAD_binding_4; pfam01565 999891002469 Berberine and berberine like; Region: BBE; pfam08031 999891002470 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 999891002471 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 999891002472 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 999891002473 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 999891002474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891002475 dimer interface [polypeptide binding]; other site 999891002476 conserved gate region; other site 999891002477 putative PBP binding loops; other site 999891002478 ABC-ATPase subunit interface; other site 999891002479 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 999891002480 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 999891002481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891002482 dimer interface [polypeptide binding]; other site 999891002483 conserved gate region; other site 999891002484 putative PBP binding loops; other site 999891002485 ABC-ATPase subunit interface; other site 999891002486 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 999891002487 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 999891002488 Walker A/P-loop; other site 999891002489 ATP binding site [chemical binding]; other site 999891002490 Q-loop/lid; other site 999891002491 ABC transporter signature motif; other site 999891002492 Walker B; other site 999891002493 D-loop; other site 999891002494 H-loop/switch region; other site 999891002495 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 999891002496 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 999891002497 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 999891002498 Walker A/P-loop; other site 999891002499 ATP binding site [chemical binding]; other site 999891002500 Q-loop/lid; other site 999891002501 ABC transporter signature motif; other site 999891002502 Walker B; other site 999891002503 D-loop; other site 999891002504 H-loop/switch region; other site 999891002505 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 999891002506 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 999891002507 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 999891002508 tetramer interface [polypeptide binding]; other site 999891002509 heme binding pocket [chemical binding]; other site 999891002510 NADPH binding site [chemical binding]; other site 999891002511 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 999891002512 active site 999891002513 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 999891002514 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 999891002515 Walker A/P-loop; other site 999891002516 ATP binding site [chemical binding]; other site 999891002517 Q-loop/lid; other site 999891002518 ABC transporter signature motif; other site 999891002519 Walker B; other site 999891002520 D-loop; other site 999891002521 H-loop/switch region; other site 999891002522 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 999891002523 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999891002524 substrate binding pocket [chemical binding]; other site 999891002525 membrane-bound complex binding site; other site 999891002526 hinge residues; other site 999891002527 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 999891002528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891002529 dimer interface [polypeptide binding]; other site 999891002530 conserved gate region; other site 999891002531 putative PBP binding loops; other site 999891002532 ABC-ATPase subunit interface; other site 999891002533 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 999891002534 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 999891002535 active site 999891002536 dimer interface [polypeptide binding]; other site 999891002537 non-prolyl cis peptide bond; other site 999891002538 insertion regions; other site 999891002539 potential frameshift: common BLAST hit: gi|308172874|ref|YP_003919579.1| sulfur oxidoreductase 999891002540 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 999891002541 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891002542 non-specific DNA binding site [nucleotide binding]; other site 999891002543 salt bridge; other site 999891002544 sequence-specific DNA binding site [nucleotide binding]; other site 999891002545 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 999891002546 epoxyqueuosine reductase; Region: TIGR00276 999891002547 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 999891002548 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 999891002549 Putative amidase domain; Region: Amidase_6; pfam12671 999891002550 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 999891002551 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 999891002552 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 999891002553 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 999891002554 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 999891002555 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 999891002556 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 999891002557 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 999891002558 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891002559 MarR family; Region: MarR; pfam01047 999891002560 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 999891002561 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 999891002562 carboxyltransferase (CT) interaction site; other site 999891002563 biotinylation site [posttranslational modification]; other site 999891002564 HlyD family secretion protein; Region: HlyD_3; pfam13437 999891002565 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 999891002566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891002567 putative substrate translocation pore; other site 999891002568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891002569 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 999891002570 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 999891002571 Predicted transcriptional regulators [Transcription]; Region: COG1725 999891002572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891002573 DNA-binding site [nucleotide binding]; DNA binding site 999891002574 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 999891002575 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 999891002576 Walker A/P-loop; other site 999891002577 ATP binding site [chemical binding]; other site 999891002578 Q-loop/lid; other site 999891002579 ABC transporter signature motif; other site 999891002580 Walker B; other site 999891002581 D-loop; other site 999891002582 H-loop/switch region; other site 999891002583 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 999891002584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891002585 Walker A/P-loop; other site 999891002586 ATP binding site [chemical binding]; other site 999891002587 Q-loop/lid; other site 999891002588 ABC transporter signature motif; other site 999891002589 Walker B; other site 999891002590 D-loop; other site 999891002591 H-loop/switch region; other site 999891002592 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 999891002593 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 999891002594 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 999891002595 DNA-binding site [nucleotide binding]; DNA binding site 999891002596 RNA-binding motif; other site 999891002597 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 999891002598 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 999891002599 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 999891002600 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 999891002601 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 999891002602 metal binding site [ion binding]; metal-binding site 999891002603 active site 999891002604 I-site; other site 999891002605 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 999891002606 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 999891002607 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 999891002608 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 999891002609 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 999891002610 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 999891002611 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 999891002612 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 999891002613 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 999891002614 putative active site [active] 999891002615 putative metal binding site [ion binding]; other site 999891002616 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 999891002617 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 999891002618 active site 999891002619 catalytic site [active] 999891002620 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 999891002621 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 999891002622 active site 999891002623 FOG: CBS domain [General function prediction only]; Region: COG0517 999891002624 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 999891002625 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 999891002626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891002627 motif II; other site 999891002628 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 999891002629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891002630 Coenzyme A binding pocket [chemical binding]; other site 999891002631 Predicted amidohydrolase [General function prediction only]; Region: COG0388 999891002632 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 999891002633 putative active site [active] 999891002634 catalytic triad [active] 999891002635 putative dimer interface [polypeptide binding]; other site 999891002636 aminotransferase; Validated; Region: PRK07678 999891002637 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 999891002638 inhibitor-cofactor binding pocket; inhibition site 999891002639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891002640 catalytic residue [active] 999891002641 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 999891002642 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 999891002643 amphipathic channel; other site 999891002644 Asn-Pro-Ala signature motifs; other site 999891002645 glycerol kinase; Provisional; Region: glpK; PRK00047 999891002646 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 999891002647 N- and C-terminal domain interface [polypeptide binding]; other site 999891002648 active site 999891002649 MgATP binding site [chemical binding]; other site 999891002650 catalytic site [active] 999891002651 metal binding site [ion binding]; metal-binding site 999891002652 glycerol binding site [chemical binding]; other site 999891002653 homotetramer interface [polypeptide binding]; other site 999891002654 homodimer interface [polypeptide binding]; other site 999891002655 FBP binding site [chemical binding]; other site 999891002656 protein IIAGlc interface [polypeptide binding]; other site 999891002657 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 999891002658 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 999891002659 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 999891002660 active site 999891002661 substrate binding site [chemical binding]; other site 999891002662 metal binding site [ion binding]; metal-binding site 999891002663 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 999891002664 GAF domain; Region: GAF; pfam01590 999891002665 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 999891002666 Histidine kinase; Region: HisKA_3; pfam07730 999891002667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891002668 ATP binding site [chemical binding]; other site 999891002669 Mg2+ binding site [ion binding]; other site 999891002670 G-X-G motif; other site 999891002671 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 999891002672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891002673 active site 999891002674 phosphorylation site [posttranslational modification] 999891002675 intermolecular recognition site; other site 999891002676 dimerization interface [polypeptide binding]; other site 999891002677 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 999891002678 DNA binding residues [nucleotide binding] 999891002679 dimerization interface [polypeptide binding]; other site 999891002680 Predicted flavoprotein [General function prediction only]; Region: COG0431 999891002681 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 999891002682 YhdB-like protein; Region: YhdB; pfam14148 999891002683 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 999891002684 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891002685 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891002686 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891002687 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891002688 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 999891002689 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891002690 NlpC/P60 family; Region: NLPC_P60; pfam00877 999891002691 Transcriptional regulator; Region: Rrf2; cl17282 999891002692 Rrf2 family protein; Region: rrf2_super; TIGR00738 999891002693 Conserved TM helix; Region: TM_helix; pfam05552 999891002694 Conserved TM helix; Region: TM_helix; pfam05552 999891002695 Conserved TM helix; Region: TM_helix; pfam05552 999891002696 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 999891002697 SpoVR like protein; Region: SpoVR; pfam04293 999891002698 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 999891002699 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 999891002700 dimer interface [polypeptide binding]; other site 999891002701 active site 999891002702 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891002703 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891002704 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 999891002705 NlpC/P60 family; Region: NLPC_P60; pfam00877 999891002706 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999891002707 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999891002708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 999891002709 dimerization interface [polypeptide binding]; other site 999891002710 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 999891002711 dimer interface [polypeptide binding]; other site 999891002712 Citrate synthase; Region: Citrate_synt; pfam00285 999891002713 active site 999891002714 citrylCoA binding site [chemical binding]; other site 999891002715 oxalacetate/citrate binding site [chemical binding]; other site 999891002716 coenzyme A binding site [chemical binding]; other site 999891002717 catalytic triad [active] 999891002718 short chain dehydrogenase; Provisional; Region: PRK06701 999891002719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999891002720 NAD(P) binding site [chemical binding]; other site 999891002721 active site 999891002722 amino acid transporter; Region: 2A0306; TIGR00909 999891002723 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 999891002724 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 999891002725 Na2 binding site [ion binding]; other site 999891002726 putative substrate binding site 1 [chemical binding]; other site 999891002727 Na binding site 1 [ion binding]; other site 999891002728 putative substrate binding site 2 [chemical binding]; other site 999891002729 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 999891002730 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 999891002731 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 999891002732 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999891002733 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999891002734 DNA binding residues [nucleotide binding] 999891002735 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 999891002736 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 999891002737 putative acyl-acceptor binding pocket; other site 999891002738 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 999891002739 Domain of unknown function DUF21; Region: DUF21; pfam01595 999891002740 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 999891002741 Transporter associated domain; Region: CorC_HlyC; smart01091 999891002742 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 999891002743 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 999891002744 DNA binding residues [nucleotide binding] 999891002745 putative dimer interface [polypeptide binding]; other site 999891002746 aspartate aminotransferase; Provisional; Region: PRK06836 999891002747 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891002748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891002749 homodimer interface [polypeptide binding]; other site 999891002750 catalytic residue [active] 999891002751 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 999891002752 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 999891002753 dimer interface [polypeptide binding]; other site 999891002754 active site 999891002755 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 999891002756 Domain of unknown function DUF21; Region: DUF21; pfam01595 999891002757 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 999891002758 Transporter associated domain; Region: CorC_HlyC; smart01091 999891002759 CrcB-like protein; Region: CRCB; cl09114 999891002760 CrcB-like protein; Region: CRCB; cl09114 999891002761 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 999891002762 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 999891002763 active site 999891002764 catalytic site [active] 999891002765 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 999891002766 Mechanosensitive ion channel; Region: MS_channel; pfam00924 999891002767 NAD-dependent deacetylase; Provisional; Region: PRK00481 999891002768 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 999891002769 NAD+ binding site [chemical binding]; other site 999891002770 substrate binding site [chemical binding]; other site 999891002771 Zn binding site [ion binding]; other site 999891002772 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 999891002773 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 999891002774 NodB motif; other site 999891002775 active site 999891002776 catalytic site [active] 999891002777 Zn binding site [ion binding]; other site 999891002778 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 999891002779 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 999891002780 homodimer interface [polypeptide binding]; other site 999891002781 substrate-cofactor binding pocket; other site 999891002782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891002783 catalytic residue [active] 999891002784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891002785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891002786 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 999891002787 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 999891002788 Ligand Binding Site [chemical binding]; other site 999891002789 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999891002790 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999891002791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891002792 Walker A/P-loop; other site 999891002793 ATP binding site [chemical binding]; other site 999891002794 Q-loop/lid; other site 999891002795 ABC transporter signature motif; other site 999891002796 Walker B; other site 999891002797 D-loop; other site 999891002798 H-loop/switch region; other site 999891002799 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999891002800 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999891002801 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 999891002802 Walker A/P-loop; other site 999891002803 ATP binding site [chemical binding]; other site 999891002804 Q-loop/lid; other site 999891002805 ABC transporter signature motif; other site 999891002806 Walker B; other site 999891002807 D-loop; other site 999891002808 H-loop/switch region; other site 999891002809 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 999891002810 NADH(P)-binding; Region: NAD_binding_10; pfam13460 999891002811 NAD binding site [chemical binding]; other site 999891002812 substrate binding site [chemical binding]; other site 999891002813 putative active site [active] 999891002814 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 999891002815 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 999891002816 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 999891002817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 999891002818 hypothetical protein; Provisional; Region: PRK13676 999891002819 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 999891002820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891002821 active site 999891002822 motif I; other site 999891002823 motif II; other site 999891002824 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 999891002825 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 999891002826 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 999891002827 FeS/SAM binding site; other site 999891002828 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 999891002829 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 999891002830 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 999891002831 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 999891002832 TrkA-C domain; Region: TrkA_C; pfam02080 999891002833 enoyl-CoA hydratase; Provisional; Region: PRK07659 999891002834 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 999891002835 substrate binding site [chemical binding]; other site 999891002836 oxyanion hole (OAH) forming residues; other site 999891002837 trimer interface [polypeptide binding]; other site 999891002838 YhzD-like protein; Region: YhzD; pfam14120 999891002839 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 999891002840 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 999891002841 Walker A/P-loop; other site 999891002842 ATP binding site [chemical binding]; other site 999891002843 Q-loop/lid; other site 999891002844 ABC transporter signature motif; other site 999891002845 Walker B; other site 999891002846 D-loop; other site 999891002847 H-loop/switch region; other site 999891002848 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 999891002849 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 999891002850 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 999891002851 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 999891002852 active site 999891002853 metal binding site [ion binding]; metal-binding site 999891002854 DNA binding site [nucleotide binding] 999891002855 Uncharacterized conserved protein [Function unknown]; Region: COG4717 999891002856 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 999891002857 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 999891002858 generic binding surface II; other site 999891002859 generic binding surface I; other site 999891002860 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 999891002861 Zn2+ binding site [ion binding]; other site 999891002862 Mg2+ binding site [ion binding]; other site 999891002863 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 999891002864 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 999891002865 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 999891002866 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 999891002867 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 999891002868 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 999891002869 transcriptional regulator Hpr; Provisional; Region: PRK13777 999891002870 MarR family; Region: MarR; pfam01047 999891002871 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 999891002872 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 999891002873 homodimer interface [polypeptide binding]; other site 999891002874 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 999891002875 substrate-cofactor binding pocket; other site 999891002876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891002877 catalytic residue [active] 999891002878 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 999891002879 HIT family signature motif; other site 999891002880 catalytic residue [active] 999891002881 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 999891002882 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 999891002883 Walker A/P-loop; other site 999891002884 ATP binding site [chemical binding]; other site 999891002885 Q-loop/lid; other site 999891002886 ABC transporter signature motif; other site 999891002887 Walker B; other site 999891002888 D-loop; other site 999891002889 H-loop/switch region; other site 999891002890 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 999891002891 EcsC protein family; Region: EcsC; pfam12787 999891002892 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 999891002893 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 999891002894 metal binding site [ion binding]; metal-binding site 999891002895 dimer interface [polypeptide binding]; other site 999891002896 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 999891002897 Transglycosylase; Region: Transgly; pfam00912 999891002898 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 999891002899 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 999891002900 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 999891002901 substrate binding site [chemical binding]; other site 999891002902 active site 999891002903 ferrochelatase; Provisional; Region: PRK12435 999891002904 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 999891002905 C-terminal domain interface [polypeptide binding]; other site 999891002906 active site 999891002907 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 999891002908 active site 999891002909 N-terminal domain interface [polypeptide binding]; other site 999891002910 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 999891002911 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 999891002912 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891002913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891002914 Predicted membrane protein [Function unknown]; Region: COG1511 999891002915 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 999891002916 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 999891002917 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 999891002918 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 999891002919 dimer interface [polypeptide binding]; other site 999891002920 active site 999891002921 CoA binding pocket [chemical binding]; other site 999891002922 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 999891002923 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 999891002924 putative oligomer interface [polypeptide binding]; other site 999891002925 putative active site [active] 999891002926 metal binding site [ion binding]; metal-binding site 999891002927 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 999891002928 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 999891002929 YhfH-like protein; Region: YhfH; pfam14149 999891002930 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 999891002931 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 999891002932 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 999891002933 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 999891002934 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 999891002935 NADH(P)-binding; Region: NAD_binding_10; pfam13460 999891002936 NAD(P) binding site [chemical binding]; other site 999891002937 putative active site [active] 999891002938 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 999891002939 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 999891002940 acyl-activating enzyme (AAE) consensus motif; other site 999891002941 putative AMP binding site [chemical binding]; other site 999891002942 putative active site [active] 999891002943 putative CoA binding site [chemical binding]; other site 999891002944 Peptidase family M48; Region: Peptidase_M48; pfam01435 999891002945 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 999891002946 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 999891002947 active site 999891002948 catalytic residues [active] 999891002949 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 999891002950 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 999891002951 siderophore binding site; other site 999891002952 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 999891002953 catalytic core [active] 999891002954 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 999891002955 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 999891002956 dimer interface [polypeptide binding]; other site 999891002957 active site 999891002958 acyl-CoA synthetase; Validated; Region: PRK07638 999891002959 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 999891002960 acyl-activating enzyme (AAE) consensus motif; other site 999891002961 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 999891002962 acyl-activating enzyme (AAE) consensus motif; other site 999891002963 active site 999891002964 AMP binding site [chemical binding]; other site 999891002965 CoA binding site [chemical binding]; other site 999891002966 BioY family; Region: BioY; pfam02632 999891002967 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 999891002968 heme-binding site [chemical binding]; other site 999891002969 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 999891002970 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 999891002971 dimer interface [polypeptide binding]; other site 999891002972 putative CheW interface [polypeptide binding]; other site 999891002973 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 999891002974 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 999891002975 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 999891002976 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 999891002977 [2Fe-2S] cluster binding site [ion binding]; other site 999891002978 short chain dehydrogenase; Provisional; Region: PRK06701 999891002979 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 999891002980 NAD binding site [chemical binding]; other site 999891002981 metal binding site [ion binding]; metal-binding site 999891002982 active site 999891002983 IDEAL domain; Region: IDEAL; pfam08858 999891002984 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 999891002985 Uncharacterized conserved protein [Function unknown]; Region: COG5646 999891002986 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 999891002987 Sterol carrier protein domain; Region: SCP2_2; pfam13530 999891002988 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 999891002989 putative binding site; other site 999891002990 putative dimer interface [polypeptide binding]; other site 999891002991 Excalibur calcium-binding domain; Region: Excalibur; cl05460 999891002992 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 999891002993 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 999891002994 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 999891002995 Na binding site [ion binding]; other site 999891002996 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 999891002997 Uncharacterized conserved protein [Function unknown]; Region: COG0398 999891002998 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 999891002999 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 999891003000 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 999891003001 Catalytic site [active] 999891003002 hypothetical protein; Provisional; Region: PRK08244 999891003003 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 999891003004 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891003005 MarR family; Region: MarR; pfam01047 999891003006 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 999891003007 Putative ammonia monooxygenase; Region: AmoA; pfam05145 999891003008 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 999891003009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891003010 putative substrate translocation pore; other site 999891003011 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891003012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891003013 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891003014 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 999891003015 Uncharacterized conserved protein [Function unknown]; Region: COG1633 999891003016 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 999891003017 dinuclear metal binding motif [ion binding]; other site 999891003018 Predicted membrane protein [Function unknown]; Region: COG2323 999891003019 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 999891003020 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 999891003021 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 999891003022 Part of AAA domain; Region: AAA_19; pfam13245 999891003023 Family description; Region: UvrD_C_2; pfam13538 999891003024 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 999891003025 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 999891003026 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 999891003027 active site 999891003028 metal binding site [ion binding]; metal-binding site 999891003029 DNA binding site [nucleotide binding] 999891003030 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 999891003031 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 999891003032 AAA domain; Region: AAA_23; pfam13476 999891003033 Walker A/P-loop; other site 999891003034 ATP binding site [chemical binding]; other site 999891003035 Q-loop/lid; other site 999891003036 ABC transporter signature motif; other site 999891003037 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 999891003038 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 999891003039 ABC transporter signature motif; other site 999891003040 Walker B; other site 999891003041 D-loop; other site 999891003042 H-loop/switch region; other site 999891003043 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 999891003044 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 999891003045 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 999891003046 Spore germination protein GerPC; Region: GerPC; pfam10737 999891003047 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 999891003048 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 999891003049 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 999891003050 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 999891003051 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 999891003052 hypothetical protein; Provisional; Region: PRK13673 999891003053 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 999891003054 active site 999891003055 catalytic triad [active] 999891003056 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 999891003057 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 999891003058 active site 999891003059 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 999891003060 dimer interface [polypeptide binding]; other site 999891003061 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 999891003062 Ligand Binding Site [chemical binding]; other site 999891003063 Molecular Tunnel; other site 999891003064 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 999891003065 substrate binding pocket [chemical binding]; other site 999891003066 substrate-Mg2+ binding site; other site 999891003067 aspartate-rich region 1; other site 999891003068 aspartate-rich region 2; other site 999891003069 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 999891003070 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 999891003071 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 999891003072 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 999891003073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 999891003074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 999891003075 Transcriptional regulators [Transcription]; Region: PurR; COG1609 999891003076 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999891003077 DNA binding site [nucleotide binding] 999891003078 domain linker motif; other site 999891003079 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 999891003080 dimerization interface [polypeptide binding]; other site 999891003081 ligand binding site [chemical binding]; other site 999891003082 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 999891003083 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 999891003084 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 999891003085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 999891003086 Lysine efflux permease [General function prediction only]; Region: COG1279 999891003087 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 999891003088 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891003089 DNA-binding site [nucleotide binding]; DNA binding site 999891003090 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891003091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891003092 homodimer interface [polypeptide binding]; other site 999891003093 catalytic residue [active] 999891003094 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 999891003095 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 999891003096 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 999891003097 Coenzyme A binding pocket [chemical binding]; other site 999891003098 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 999891003099 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 999891003100 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 999891003101 FAD binding site [chemical binding]; other site 999891003102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 999891003103 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 999891003104 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 999891003105 S1 domain; Region: S1_2; pfam13509 999891003106 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 999891003107 RNA binding site [nucleotide binding]; other site 999891003108 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 999891003109 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 999891003110 ligand binding site [chemical binding]; other site 999891003111 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 999891003112 dimerization interface [polypeptide binding]; other site 999891003113 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 999891003114 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 999891003115 dimer interface [polypeptide binding]; other site 999891003116 putative CheW interface [polypeptide binding]; other site 999891003117 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 999891003118 Cytochrome P450; Region: p450; cl12078 999891003119 EDD domain protein, DegV family; Region: DegV; TIGR00762 999891003120 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 999891003121 Uncharacterized conserved protein [Function unknown]; Region: COG1284 999891003122 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999891003123 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999891003124 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 999891003125 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 999891003126 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 999891003127 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 999891003128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891003129 motif II; other site 999891003130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891003131 esterase; Provisional; Region: PRK10566 999891003132 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 999891003133 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 999891003134 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 999891003135 active site 999891003136 metal binding site [ion binding]; metal-binding site 999891003137 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 999891003138 FAD binding domain; Region: FAD_binding_4; pfam01565 999891003139 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 999891003140 purine nucleoside phosphorylase; Provisional; Region: PRK08202 999891003141 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 999891003142 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 999891003143 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 999891003144 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 999891003145 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 999891003146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891003147 ATP binding site [chemical binding]; other site 999891003148 Mg2+ binding site [ion binding]; other site 999891003149 G-X-G motif; other site 999891003150 sporulation sigma factor SigF; Validated; Region: PRK05572 999891003151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999891003152 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 999891003153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999891003154 DNA binding residues [nucleotide binding] 999891003155 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 999891003156 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 999891003157 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 999891003158 stage V sporulation protein AD; Validated; Region: PRK08304 999891003159 stage V sporulation protein AD; Provisional; Region: PRK12404 999891003160 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 999891003161 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 999891003162 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 999891003163 diaminopimelate decarboxylase; Region: lysA; TIGR01048 999891003164 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 999891003165 active site 999891003166 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 999891003167 substrate binding site [chemical binding]; other site 999891003168 catalytic residues [active] 999891003169 dimer interface [polypeptide binding]; other site 999891003170 Predicted secreted protein [Function unknown]; Region: COG4086 999891003171 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 999891003172 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 999891003173 active site 999891003174 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 999891003175 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 999891003176 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 999891003177 Catalytic site [active] 999891003178 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 999891003179 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 999891003180 catalytic motif [active] 999891003181 Zn binding site [ion binding]; other site 999891003182 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 999891003183 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 999891003184 Lumazine binding domain; Region: Lum_binding; pfam00677 999891003185 Lumazine binding domain; Region: Lum_binding; pfam00677 999891003186 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 999891003187 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 999891003188 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 999891003189 dimerization interface [polypeptide binding]; other site 999891003190 active site 999891003191 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 999891003192 homopentamer interface [polypeptide binding]; other site 999891003193 active site 999891003194 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891003195 Coenzyme A binding pocket [chemical binding]; other site 999891003196 Domain of unknown function (DUF309); Region: DUF309; cl00667 999891003197 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 999891003198 segregation and condensation protein B; Region: TIGR00281 999891003199 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 999891003200 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 999891003201 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 999891003202 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 999891003203 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 999891003204 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 999891003205 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 999891003206 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999891003207 RNA binding surface [nucleotide binding]; other site 999891003208 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 999891003209 active site 999891003210 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 999891003211 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 999891003212 catalytic residues [active] 999891003213 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 999891003214 ResB-like family; Region: ResB; pfam05140 999891003215 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 999891003216 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 999891003217 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999891003218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891003219 active site 999891003220 phosphorylation site [posttranslational modification] 999891003221 intermolecular recognition site; other site 999891003222 dimerization interface [polypeptide binding]; other site 999891003223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999891003224 DNA binding site [nucleotide binding] 999891003225 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 999891003226 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 999891003227 dimerization interface [polypeptide binding]; other site 999891003228 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 999891003229 putative active site [active] 999891003230 heme pocket [chemical binding]; other site 999891003231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891003232 dimer interface [polypeptide binding]; other site 999891003233 phosphorylation site [posttranslational modification] 999891003234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891003235 ATP binding site [chemical binding]; other site 999891003236 Mg2+ binding site [ion binding]; other site 999891003237 G-X-G motif; other site 999891003238 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 999891003239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999891003240 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999891003241 DNA binding residues [nucleotide binding] 999891003242 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 999891003243 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 999891003244 ligand binding site [chemical binding]; other site 999891003245 NAD binding site [chemical binding]; other site 999891003246 dimerization interface [polypeptide binding]; other site 999891003247 catalytic site [active] 999891003248 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 999891003249 putative L-serine binding site [chemical binding]; other site 999891003250 Predicted membrane protein [Function unknown]; Region: COG3601 999891003251 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 999891003252 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 999891003253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 999891003254 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 999891003255 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999891003256 ATP binding site [chemical binding]; other site 999891003257 putative Mg++ binding site [ion binding]; other site 999891003258 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999891003259 nucleotide binding region [chemical binding]; other site 999891003260 ATP-binding site [chemical binding]; other site 999891003261 CAAX protease self-immunity; Region: Abi; pfam02517 999891003262 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891003263 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 999891003264 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 999891003265 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 999891003266 putative active site [active] 999891003267 putative metal binding site [ion binding]; other site 999891003268 adaptor protein; Provisional; Region: PRK02899 999891003269 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 999891003270 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 999891003271 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 999891003272 NAD(P) binding site [chemical binding]; other site 999891003273 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 999891003274 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 999891003275 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 999891003276 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 999891003277 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 999891003278 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 999891003279 germination protein YpeB; Region: spore_YpeB; TIGR02889 999891003280 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 999891003281 Flagellar protein YcgR; Region: YcgR_2; pfam12945 999891003282 PilZ domain; Region: PilZ; pfam07238 999891003283 cytidylate kinase; Provisional; Region: cmk; PRK00023 999891003284 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 999891003285 CMP-binding site; other site 999891003286 The sites determining sugar specificity; other site 999891003287 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 999891003288 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 999891003289 RNA binding site [nucleotide binding]; other site 999891003290 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 999891003291 RNA binding site [nucleotide binding]; other site 999891003292 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 999891003293 RNA binding site [nucleotide binding]; other site 999891003294 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 999891003295 RNA binding site [nucleotide binding]; other site 999891003296 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 999891003297 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 999891003298 homotetramer interface [polypeptide binding]; other site 999891003299 FMN binding site [chemical binding]; other site 999891003300 homodimer contacts [polypeptide binding]; other site 999891003301 putative active site [active] 999891003302 putative substrate binding site [chemical binding]; other site 999891003303 YpzI-like protein; Region: YpzI; pfam14140 999891003304 GTP-binding protein Der; Reviewed; Region: PRK00093 999891003305 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 999891003306 G1 box; other site 999891003307 GTP/Mg2+ binding site [chemical binding]; other site 999891003308 Switch I region; other site 999891003309 G2 box; other site 999891003310 Switch II region; other site 999891003311 G3 box; other site 999891003312 G4 box; other site 999891003313 G5 box; other site 999891003314 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 999891003315 G1 box; other site 999891003316 GTP/Mg2+ binding site [chemical binding]; other site 999891003317 Switch I region; other site 999891003318 G2 box; other site 999891003319 G3 box; other site 999891003320 Switch II region; other site 999891003321 G4 box; other site 999891003322 G5 box; other site 999891003323 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 999891003324 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 999891003325 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 999891003326 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 999891003327 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 999891003328 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 999891003329 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 999891003330 IHF dimer interface [polypeptide binding]; other site 999891003331 IHF - DNA interface [nucleotide binding]; other site 999891003332 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 999891003333 homodecamer interface [polypeptide binding]; other site 999891003334 GTP cyclohydrolase I; Provisional; Region: PLN03044 999891003335 active site 999891003336 putative catalytic site residues [active] 999891003337 zinc binding site [ion binding]; other site 999891003338 GTP-CH-I/GFRP interaction surface; other site 999891003339 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 999891003340 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 999891003341 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 999891003342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891003343 S-adenosylmethionine binding site [chemical binding]; other site 999891003344 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 999891003345 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 999891003346 substrate binding pocket [chemical binding]; other site 999891003347 chain length determination region; other site 999891003348 substrate-Mg2+ binding site; other site 999891003349 catalytic residues [active] 999891003350 aspartate-rich region 1; other site 999891003351 active site lid residues [active] 999891003352 aspartate-rich region 2; other site 999891003353 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 999891003354 active site 999891003355 multimer interface [polypeptide binding]; other site 999891003356 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 999891003357 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 999891003358 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 999891003359 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 999891003360 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 999891003361 Tetramer interface [polypeptide binding]; other site 999891003362 active site 999891003363 FMN-binding site [chemical binding]; other site 999891003364 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 999891003365 active site 999891003366 dimer interface [polypeptide binding]; other site 999891003367 metal binding site [ion binding]; metal-binding site 999891003368 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 999891003369 homotrimer interaction site [polypeptide binding]; other site 999891003370 active site 999891003371 anthranilate synthase component I; Provisional; Region: PRK13569 999891003372 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 999891003373 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 999891003374 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 999891003375 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 999891003376 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 999891003377 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 999891003378 active site 999891003379 ribulose/triose binding site [chemical binding]; other site 999891003380 phosphate binding site [ion binding]; other site 999891003381 substrate (anthranilate) binding pocket [chemical binding]; other site 999891003382 product (indole) binding pocket [chemical binding]; other site 999891003383 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 999891003384 active site 999891003385 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 999891003386 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 999891003387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891003388 catalytic residue [active] 999891003389 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 999891003390 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 999891003391 substrate binding site [chemical binding]; other site 999891003392 active site 999891003393 catalytic residues [active] 999891003394 heterodimer interface [polypeptide binding]; other site 999891003395 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 999891003396 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891003397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891003398 homodimer interface [polypeptide binding]; other site 999891003399 catalytic residue [active] 999891003400 prephenate dehydrogenase; Validated; Region: PRK06545 999891003401 prephenate dehydrogenase; Validated; Region: PRK08507 999891003402 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 999891003403 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 999891003404 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 999891003405 hinge; other site 999891003406 active site 999891003407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 999891003408 TPR motif; other site 999891003409 binding surface 999891003410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891003411 binding surface 999891003412 TPR motif; other site 999891003413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891003414 TPR motif; other site 999891003415 binding surface 999891003416 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 999891003417 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891003418 binding surface 999891003419 TPR motif; other site 999891003420 hypothetical protein; Provisional; Region: PRK03636 999891003421 UPF0302 domain; Region: UPF0302; pfam08864 999891003422 IDEAL domain; Region: IDEAL; pfam08858 999891003423 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 999891003424 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 999891003425 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 999891003426 iron-sulfur cluster [ion binding]; other site 999891003427 [2Fe-2S] cluster binding site [ion binding]; other site 999891003428 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 999891003429 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 999891003430 interchain domain interface [polypeptide binding]; other site 999891003431 intrachain domain interface; other site 999891003432 heme bH binding site [chemical binding]; other site 999891003433 Qi binding site; other site 999891003434 heme bL binding site [chemical binding]; other site 999891003435 Qo binding site; other site 999891003436 Qo binding site; other site 999891003437 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 999891003438 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 999891003439 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 999891003440 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 999891003441 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 999891003442 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 999891003443 Cupin; Region: Cupin_1; smart00835 999891003444 Cupin; Region: Cupin_1; smart00835 999891003445 Uncharacterized conserved protein [Function unknown]; Region: COG1284 999891003446 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999891003447 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999891003448 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 999891003449 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 999891003450 homodimer interface [polypeptide binding]; other site 999891003451 metal binding site [ion binding]; metal-binding site 999891003452 dihydrodipicolinate reductase; Region: dapB; TIGR00036 999891003453 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 999891003454 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 999891003455 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 999891003456 active site 999891003457 dimer interfaces [polypeptide binding]; other site 999891003458 catalytic residues [active] 999891003459 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 999891003460 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 999891003461 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 999891003462 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 999891003463 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 999891003464 active site 999891003465 NTP binding site [chemical binding]; other site 999891003466 metal binding triad [ion binding]; metal-binding site 999891003467 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 999891003468 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 999891003469 Biotin operon repressor [Transcription]; Region: BirA; COG1654 999891003470 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 999891003471 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 999891003472 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 999891003473 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 999891003474 oligomerization interface [polypeptide binding]; other site 999891003475 active site 999891003476 metal binding site [ion binding]; metal-binding site 999891003477 Pantoate-beta-alanine ligase; Region: PanC; cd00560 999891003478 pantoate--beta-alanine ligase; Region: panC; TIGR00018 999891003479 active site 999891003480 ATP-binding site [chemical binding]; other site 999891003481 pantoate-binding site; other site 999891003482 HXXH motif; other site 999891003483 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 999891003484 tetramerization interface [polypeptide binding]; other site 999891003485 active site 999891003486 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 999891003487 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 999891003488 active site 999891003489 catalytic site [active] 999891003490 substrate binding site [chemical binding]; other site 999891003491 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 999891003492 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 999891003493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 999891003494 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 999891003495 aspartate aminotransferase; Provisional; Region: PRK05764 999891003496 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891003497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891003498 homodimer interface [polypeptide binding]; other site 999891003499 catalytic residue [active] 999891003500 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 999891003501 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 999891003502 putative dimer interface [polypeptide binding]; other site 999891003503 putative anticodon binding site; other site 999891003504 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 999891003505 homodimer interface [polypeptide binding]; other site 999891003506 motif 1; other site 999891003507 motif 2; other site 999891003508 active site 999891003509 motif 3; other site 999891003510 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 999891003511 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 999891003512 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 999891003513 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 999891003514 minor groove reading motif; other site 999891003515 helix-hairpin-helix signature motif; other site 999891003516 substrate binding pocket [chemical binding]; other site 999891003517 active site 999891003518 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 999891003519 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 999891003520 Transglycosylase; Region: Transgly; pfam00912 999891003521 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 999891003522 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 999891003523 Interdomain contacts; other site 999891003524 Cytokine receptor motif; other site 999891003525 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 999891003526 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 999891003527 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 999891003528 YppF-like protein; Region: YppF; pfam14178 999891003529 YppG-like protein; Region: YppG; pfam14179 999891003530 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 999891003531 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 999891003532 HPr interaction site; other site 999891003533 glycerol kinase (GK) interaction site [polypeptide binding]; other site 999891003534 active site 999891003535 phosphorylation site [posttranslational modification] 999891003536 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 999891003537 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999891003538 ATP binding site [chemical binding]; other site 999891003539 putative Mg++ binding site [ion binding]; other site 999891003540 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999891003541 nucleotide binding region [chemical binding]; other site 999891003542 ATP-binding site [chemical binding]; other site 999891003543 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 999891003544 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 999891003545 RNase_H superfamily; Region: RNase_H_2; pfam13482 999891003546 active site 999891003547 substrate binding site [chemical binding]; other site 999891003548 catalytic site [active] 999891003549 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 999891003550 hypothetical protein; Provisional; Region: PRK13660 999891003551 cell division protein GpsB; Provisional; Region: PRK14127 999891003552 DivIVA domain; Region: DivI1A_domain; TIGR03544 999891003553 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 999891003554 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 999891003555 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 999891003556 YpzG-like protein; Region: YpzG; pfam14139 999891003557 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 999891003558 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 999891003559 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 999891003560 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 999891003561 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 999891003562 active site 999891003563 Zn binding site [ion binding]; other site 999891003564 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999891003565 active site 999891003566 xanthine permease; Region: pbuX; TIGR03173 999891003567 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 999891003568 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 999891003569 catalytic residues [active] 999891003570 catalytic nucleophile [active] 999891003571 Recombinase; Region: Recombinase; pfam07508 999891003572 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 999891003573 Staphylococcal nuclease homologues; Region: SNc; smart00318 999891003574 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 999891003575 Catalytic site; other site 999891003576 Excalibur calcium-binding domain; Region: Excalibur; smart00894 999891003577 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 999891003578 LXG domain of WXG superfamily; Region: LXG; pfam04740 999891003579 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 999891003580 active site 999891003581 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 999891003582 potential frameshift: common BLAST hit: gi|308174929|ref|YP_003921634.1| protein involved in spore formation 999891003583 YolD-like protein; Region: YolD; pfam08863 999891003584 DNA polymerase IV; Reviewed; Region: PRK03103 999891003585 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 999891003586 active site 999891003587 DNA binding site [nucleotide binding] 999891003588 potential frameshift: common BLAST hit: gi|323651054|ref|YP_004243697.1| response regulator aspartate phosphatase 999891003589 Bacteriophage holin; Region: Phage_holin_1; pfam04531 999891003590 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 999891003591 amidase catalytic site [active] 999891003592 Zn binding residues [ion binding]; other site 999891003593 substrate binding site [chemical binding]; other site 999891003594 Bacterial SH3 domain; Region: SH3_3; pfam08239 999891003595 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 999891003596 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 999891003597 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 999891003598 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 999891003599 Phage-related protein [Function unknown]; Region: COG4722 999891003600 Phage tail protein; Region: Sipho_tail; cl17486 999891003601 potential frameshift: common BLAST hit: gi|255767473|ref|NP_390018.2| SPbeta phage protein; lytic transglycosylase 999891003602 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 999891003603 Catalytic domain of Protein Kinases; Region: PKc; cd00180 999891003604 active site 999891003605 ATP binding site [chemical binding]; other site 999891003606 substrate binding site [chemical binding]; other site 999891003607 activation loop (A-loop); other site 999891003608 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 999891003609 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 999891003610 active site 999891003611 catalytic residues [active] 999891003612 DNA binding site [nucleotide binding] 999891003613 Int/Topo IB signature motif; other site 999891003614 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 999891003615 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 999891003616 active site 999891003617 catalytic site [active] 999891003618 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 999891003619 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 999891003620 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 999891003621 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 999891003622 protein-splicing catalytic site; other site 999891003623 thioester formation/cholesterol transfer; other site 999891003624 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 999891003625 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 999891003626 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 999891003627 IHF - DNA interface [nucleotide binding]; other site 999891003628 IHF dimer interface [polypeptide binding]; other site 999891003629 RNA dependent RNA polymerase; Region: RdRP; pfam05183 999891003630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891003631 sequence-specific DNA binding site [nucleotide binding]; other site 999891003632 salt bridge; other site 999891003633 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 999891003634 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 999891003635 nucleotide binding site [chemical binding]; other site 999891003636 ORF6C domain; Region: ORF6C; pfam10552 999891003637 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 999891003638 Part of AAA domain; Region: AAA_19; pfam13245 999891003639 Family description; Region: UvrD_C_2; pfam13538 999891003640 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 999891003641 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 999891003642 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 999891003643 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 999891003644 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 999891003645 HIRAN domain; Region: HIRAN; cl07418 999891003646 Holliday junction DNA helicase ruvB N-terminus; Region: RuvB_N; pfam05496 999891003647 UPF0489 domain; Region: UPF0489; pfam12640 999891003648 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891003649 non-specific DNA binding site [nucleotide binding]; other site 999891003650 salt bridge; other site 999891003651 sequence-specific DNA binding site [nucleotide binding]; other site 999891003652 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 999891003653 active site 999891003654 DNA binding site [nucleotide binding] 999891003655 Int/Topo IB signature motif; other site 999891003656 DNA-sulfur modification-associated; Region: DndB; pfam14072 999891003657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891003658 salt bridge; other site 999891003659 non-specific DNA binding site [nucleotide binding]; other site 999891003660 sequence-specific DNA binding site [nucleotide binding]; other site 999891003661 Hypothetical protein Yopt; Region: Yopt; pfam09467 999891003662 SEC7 domain proteins [General function prediction only]; Region: COG5307 999891003663 YopX protein; Region: YopX; cl09859 999891003664 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 999891003665 DNA methylase; Region: N6_N4_Mtase; pfam01555 999891003666 YoqO-like protein; Region: YoqO; pfam14037 999891003667 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 999891003668 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 999891003669 active site 999891003670 DNA binding site [nucleotide binding] 999891003671 Uncharacterized conserved protein [Function unknown]; Region: COG2135 999891003672 YopX protein; Region: YopX; pfam09643 999891003673 Protein of unknown function (DUF867); Region: DUF867; pfam05908 999891003674 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 999891003675 Right handed beta helix region; Region: Beta_helix; pfam13229 999891003676 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 999891003677 Right handed beta helix region; Region: Beta_helix; pfam13229 999891003678 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 999891003679 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 999891003680 active site 999891003681 metal binding site [ion binding]; metal-binding site 999891003682 AAA domain; Region: AAA_24; pfam13479 999891003683 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 999891003684 Walker A motif; other site 999891003685 ATP binding site [chemical binding]; other site 999891003686 hypothetical protein; Provisional; Region: PRK08624 999891003687 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 999891003688 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 999891003689 active site 999891003690 metal binding site [ion binding]; metal-binding site 999891003691 interdomain interaction site; other site 999891003692 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 999891003693 DHH family; Region: DHH; pfam01368 999891003694 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 999891003695 active site 999891003696 substrate binding site [chemical binding]; other site 999891003697 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 999891003698 active site 999891003699 DNA binding site [nucleotide binding] 999891003700 catalytic site [active] 999891003701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 999891003702 YorP protein; Region: YorP; pfam09629 999891003703 ribulose-bisphosphate carboxylase small chain; Region: PLN02289 999891003704 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 999891003705 AAA domain; Region: AAA_18; pfam13238 999891003706 active site 999891003707 5'(3')-deoxyribonucleotidase [Nucleotide transport and metabolism]; Region: COG4502 999891003708 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 999891003709 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 999891003710 cofactor binding site; other site 999891003711 DNA binding site [nucleotide binding] 999891003712 substrate interaction site [chemical binding]; other site 999891003713 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 999891003714 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 999891003715 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 999891003716 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 999891003717 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 999891003718 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 999891003719 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 999891003720 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 999891003721 dimer interface [polypeptide binding]; other site 999891003722 putative radical transfer pathway; other site 999891003723 diiron center [ion binding]; other site 999891003724 tyrosyl radical; other site 999891003725 HNH endonuclease; Region: HNH_3; pfam13392 999891003726 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 999891003727 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 999891003728 Peptidyl-tRNA hydrolase PTH2; Region: PTH2; pfam01981 999891003729 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 999891003730 dimer interface [polypeptide binding]; other site 999891003731 putative active site [active] 999891003732 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 999891003733 trimer interface [polypeptide binding]; other site 999891003734 active site 999891003735 thymidylate synthase; Reviewed; Region: thyA; PRK01827 999891003736 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 999891003737 dimerization interface [polypeptide binding]; other site 999891003738 active site 999891003739 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 999891003740 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 999891003741 folate binding site [chemical binding]; other site 999891003742 NADP+ binding site [chemical binding]; other site 999891003743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891003744 non-specific DNA binding site [nucleotide binding]; other site 999891003745 salt bridge; other site 999891003746 sequence-specific DNA binding site [nucleotide binding]; other site 999891003747 Penicillin-binding protein-related factor A, putative recombinase [General function prediction only]; Region: PrfA; COG3331 999891003748 xanthine permease; Region: pbuX; TIGR03173 999891003749 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 999891003750 DNA binding site [nucleotide binding] 999891003751 active site 999891003752 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 999891003753 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 999891003754 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 999891003755 malonyl-CoA binding site [chemical binding]; other site 999891003756 dimer interface [polypeptide binding]; other site 999891003757 active site 999891003758 product binding site; other site 999891003759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 999891003760 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 999891003761 Dynamin family; Region: Dynamin_N; pfam00350 999891003762 G1 box; other site 999891003763 GTP/Mg2+ binding site [chemical binding]; other site 999891003764 G2 box; other site 999891003765 Switch I region; other site 999891003766 G3 box; other site 999891003767 Switch II region; other site 999891003768 G4 box; other site 999891003769 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 999891003770 G1 box; other site 999891003771 GTP/Mg2+ binding site [chemical binding]; other site 999891003772 Dynamin family; Region: Dynamin_N; pfam00350 999891003773 G2 box; other site 999891003774 Switch I region; other site 999891003775 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 999891003776 G3 box; other site 999891003777 Switch II region; other site 999891003778 GTP/Mg2+ binding site [chemical binding]; other site 999891003779 G4 box; other site 999891003780 G5 box; other site 999891003781 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 999891003782 5'-3' exonuclease; Region: 53EXOc; smart00475 999891003783 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 999891003784 active site 999891003785 metal binding site 1 [ion binding]; metal-binding site 999891003786 putative 5' ssDNA interaction site; other site 999891003787 metal binding site 3; metal-binding site 999891003788 metal binding site 2 [ion binding]; metal-binding site 999891003789 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 999891003790 putative DNA binding site [nucleotide binding]; other site 999891003791 putative metal binding site [ion binding]; other site 999891003792 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 999891003793 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 999891003794 RNA/DNA hybrid binding site [nucleotide binding]; other site 999891003795 active site 999891003796 conserved hypothetical integral membrane protein; Region: TIGR00697 999891003797 hypothetical protein; Validated; Region: PRK07708 999891003798 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 999891003799 RNA/DNA hybrid binding site [nucleotide binding]; other site 999891003800 active site 999891003801 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 999891003802 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 999891003803 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 999891003804 DNA-binding site [nucleotide binding]; DNA binding site 999891003805 RNA-binding motif; other site 999891003806 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 999891003807 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 999891003808 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 999891003809 homoserine O-succinyltransferase; Provisional; Region: PRK05368 999891003810 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 999891003811 proposed active site lysine [active] 999891003812 conserved cys residue [active] 999891003813 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 999891003814 catalytic residues [active] 999891003815 dimer interface [polypeptide binding]; other site 999891003816 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 999891003817 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 999891003818 Zn2+ binding site [ion binding]; other site 999891003819 Mg2+ binding site [ion binding]; other site 999891003820 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 999891003821 Virulence factor; Region: Virulence_fact; pfam13769 999891003822 HEAT repeats; Region: HEAT_2; pfam13646 999891003823 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 999891003824 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 999891003825 Disulphide isomerase; Region: Disulph_isomer; pfam06491 999891003826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891003827 S-adenosylmethionine binding site [chemical binding]; other site 999891003828 YpjP-like protein; Region: YpjP; pfam14005 999891003829 thymidylate synthase; Reviewed; Region: thyA; PRK01827 999891003830 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 999891003831 dimerization interface [polypeptide binding]; other site 999891003832 active site 999891003833 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 999891003834 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 999891003835 folate binding site [chemical binding]; other site 999891003836 NADP+ binding site [chemical binding]; other site 999891003837 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 999891003838 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 999891003839 putative acyl-acceptor binding pocket; other site 999891003840 Haemolysin-III related; Region: HlyIII; cl03831 999891003841 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 999891003842 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 999891003843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891003844 Walker A motif; other site 999891003845 ATP binding site [chemical binding]; other site 999891003846 Walker B motif; other site 999891003847 arginine finger; other site 999891003848 threonine dehydratase; Validated; Region: PRK08639 999891003849 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 999891003850 tetramer interface [polypeptide binding]; other site 999891003851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891003852 catalytic residue [active] 999891003853 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 999891003854 putative Ile/Val binding site [chemical binding]; other site 999891003855 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 999891003856 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 999891003857 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 999891003858 Cu(I) binding site [ion binding]; other site 999891003859 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 999891003860 active site 999891003861 catalytic triad [active] 999891003862 oxyanion hole [active] 999891003863 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 999891003864 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891003865 MarR family; Region: MarR; pfam01047 999891003866 methionine sulfoxide reductase A; Provisional; Region: PRK14054 999891003867 methionine sulfoxide reductase B; Provisional; Region: PRK00222 999891003868 SelR domain; Region: SelR; pfam01641 999891003869 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 999891003870 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 999891003871 catalytic residues [active] 999891003872 catalytic nucleophile [active] 999891003873 Recombinase; Region: Recombinase; pfam07508 999891003874 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 999891003875 Regulatory protein YrvL; Region: YrvL; pfam14184 999891003876 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 999891003877 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 999891003878 putative active site [active] 999891003879 putative substrate binding site [chemical binding]; other site 999891003880 putative FMN binding site [chemical binding]; other site 999891003881 putative catalytic residues [active] 999891003882 Phytase; Region: Phytase; cl17685 999891003883 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 999891003884 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 999891003885 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 999891003886 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 999891003887 active site 999891003888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891003889 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 999891003890 Coenzyme A binding pocket [chemical binding]; other site 999891003891 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 999891003892 hypothetical protein; Provisional; Region: PRK06917 999891003893 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 999891003894 inhibitor-cofactor binding pocket; inhibition site 999891003895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891003896 catalytic residue [active] 999891003897 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 999891003898 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 999891003899 acetylornithine deacetylase; Validated; Region: PRK06915 999891003900 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 999891003901 metal binding site [ion binding]; metal-binding site 999891003902 dimer interface [polypeptide binding]; other site 999891003903 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 999891003904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891003905 Coenzyme A binding pocket [chemical binding]; other site 999891003906 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 999891003907 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 999891003908 FeS/SAM binding site; other site 999891003909 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 999891003910 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 999891003911 Zn binding site [ion binding]; other site 999891003912 toxin interface [polypeptide binding]; other site 999891003913 hypothetical protein; Provisional; Region: PRK13672 999891003914 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 999891003915 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 999891003916 YozD-like protein; Region: YozD; pfam14162 999891003917 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 999891003918 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 999891003919 active site 999891003920 YodL-like; Region: YodL; pfam14191 999891003921 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 999891003922 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 999891003923 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 999891003924 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 999891003925 Methyltransferase domain; Region: Methyltransf_31; pfam13847 999891003926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891003927 S-adenosylmethionine binding site [chemical binding]; other site 999891003928 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 999891003929 C-terminal peptidase (prc); Region: prc; TIGR00225 999891003930 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 999891003931 protein binding site [polypeptide binding]; other site 999891003932 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 999891003933 Catalytic dyad [active] 999891003934 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 999891003935 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 999891003936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891003937 DNA-binding site [nucleotide binding]; DNA binding site 999891003938 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 999891003939 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 999891003940 beta-galactosidase; Region: BGL; TIGR03356 999891003941 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 999891003942 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 999891003943 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 999891003944 Na binding site [ion binding]; other site 999891003945 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 999891003946 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 999891003947 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 999891003948 Zn binding site [ion binding]; other site 999891003949 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 999891003950 Zn binding site [ion binding]; other site 999891003951 Predicted esterase [General function prediction only]; Region: COG0400 999891003952 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 999891003953 dimer interface [polypeptide binding]; other site 999891003954 FMN binding site [chemical binding]; other site 999891003955 Predicted transcriptional regulators [Transcription]; Region: COG1733 999891003956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891003957 dimerization interface [polypeptide binding]; other site 999891003958 putative DNA binding site [nucleotide binding]; other site 999891003959 putative Zn2+ binding site [ion binding]; other site 999891003960 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 999891003961 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 999891003962 Predicted permeases [General function prediction only]; Region: RarD; COG2962 999891003963 EamA-like transporter family; Region: EamA; pfam00892 999891003964 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 999891003965 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 999891003966 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 999891003967 multidrug efflux protein; Reviewed; Region: PRK01766 999891003968 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 999891003969 cation binding site [ion binding]; other site 999891003970 Uncharacterized conserved protein [Function unknown]; Region: COG1624 999891003971 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 999891003972 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 999891003973 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 999891003974 glycosyltransferase, MGT family; Region: MGT; TIGR01426 999891003975 active site 999891003976 TDP-binding site; other site 999891003977 acceptor substrate-binding pocket; other site 999891003978 homodimer interface [polypeptide binding]; other site 999891003979 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891003980 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 999891003981 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891003982 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 999891003983 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891003984 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891003985 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 999891003986 NlpC/P60 family; Region: NLPC_P60; pfam00877 999891003987 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 999891003988 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 999891003989 E-class dimer interface [polypeptide binding]; other site 999891003990 P-class dimer interface [polypeptide binding]; other site 999891003991 active site 999891003992 Cu2+ binding site [ion binding]; other site 999891003993 Zn2+ binding site [ion binding]; other site 999891003994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891003995 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 999891003996 Walker A motif; other site 999891003997 ATP binding site [chemical binding]; other site 999891003998 Walker B motif; other site 999891003999 arginine finger; other site 999891004000 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 999891004001 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 999891004002 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 999891004003 metal ion-dependent adhesion site (MIDAS); other site 999891004004 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 999891004005 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 999891004006 TPP-binding site [chemical binding]; other site 999891004007 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 999891004008 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 999891004009 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 999891004010 E3 interaction surface; other site 999891004011 lipoyl attachment site [posttranslational modification]; other site 999891004012 e3 binding domain; Region: E3_binding; pfam02817 999891004013 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 999891004014 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 999891004015 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 999891004016 Sodium Bile acid symporter family; Region: SBF; pfam01758 999891004017 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 999891004018 Na2 binding site [ion binding]; other site 999891004019 putative substrate binding site 1 [chemical binding]; other site 999891004020 Na binding site 1 [ion binding]; other site 999891004021 putative substrate binding site 2 [chemical binding]; other site 999891004022 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 999891004023 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 999891004024 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 999891004025 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 999891004026 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 999891004027 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 999891004028 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 999891004029 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 999891004030 NAD(P) binding site [chemical binding]; other site 999891004031 catalytic residues [active] 999891004032 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 999891004033 pentamer interface [polypeptide binding]; other site 999891004034 dodecaamer interface [polypeptide binding]; other site 999891004035 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 999891004036 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 999891004037 putative dimer interface [polypeptide binding]; other site 999891004038 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 999891004039 azoreductase; Provisional; Region: PRK13556 999891004040 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 999891004041 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999891004042 ATP binding site [chemical binding]; other site 999891004043 putative Mg++ binding site [ion binding]; other site 999891004044 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999891004045 nucleotide binding region [chemical binding]; other site 999891004046 ATP-binding site [chemical binding]; other site 999891004047 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 999891004048 HRDC domain; Region: HRDC; pfam00570 999891004049 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891004050 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891004051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 999891004052 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 999891004053 putative dimer interface [polypeptide binding]; other site 999891004054 catalytic triad [active] 999891004055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 999891004056 Predicted membrane protein [Function unknown]; Region: COG2322 999891004057 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 999891004058 N-acetyl-D-glucosamine binding site [chemical binding]; other site 999891004059 catalytic residue [active] 999891004060 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891004061 dimerization interface [polypeptide binding]; other site 999891004062 putative DNA binding site [nucleotide binding]; other site 999891004063 putative Zn2+ binding site [ion binding]; other site 999891004064 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 999891004065 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891004066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891004067 WHG domain; Region: WHG; pfam13305 999891004068 Cupin domain; Region: Cupin_2; pfam07883 999891004069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 999891004070 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 999891004071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 999891004072 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 999891004073 dimer interface [polypeptide binding]; other site 999891004074 putative tRNA-binding site [nucleotide binding]; other site 999891004075 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 999891004076 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891004077 MarR family; Region: MarR_2; pfam12802 999891004078 MarR family; Region: MarR_2; cl17246 999891004079 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 999891004080 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 999891004081 putative [4Fe-4S] binding site [ion binding]; other site 999891004082 putative molybdopterin cofactor binding site [chemical binding]; other site 999891004083 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 999891004084 putative molybdopterin cofactor binding site; other site 999891004085 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 999891004086 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 999891004087 putative ligand binding site [chemical binding]; other site 999891004088 putative NAD binding site [chemical binding]; other site 999891004089 catalytic site [active] 999891004090 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 999891004091 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 999891004092 putative N- and C-terminal domain interface [polypeptide binding]; other site 999891004093 putative active site [active] 999891004094 putative MgATP binding site [chemical binding]; other site 999891004095 catalytic site [active] 999891004096 metal binding site [ion binding]; metal-binding site 999891004097 carbohydrate binding site [chemical binding]; other site 999891004098 polyol permease family; Region: 2A0118; TIGR00897 999891004099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891004100 putative substrate translocation pore; other site 999891004101 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 999891004102 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 999891004103 classical (c) SDRs; Region: SDR_c; cd05233 999891004104 NAD(P) binding site [chemical binding]; other site 999891004105 active site 999891004106 Replication terminator protein; Region: RTP; pfam02334 999891004107 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 999891004108 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 999891004109 gamma-glutamyl kinase; Provisional; Region: PRK13402 999891004110 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 999891004111 nucleotide binding site [chemical binding]; other site 999891004112 homotetrameric interface [polypeptide binding]; other site 999891004113 putative phosphate binding site [ion binding]; other site 999891004114 putative allosteric binding site; other site 999891004115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999891004116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999891004117 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 999891004118 putative dimerization interface [polypeptide binding]; other site 999891004119 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 999891004120 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 999891004121 active site 999891004122 dimer interface [polypeptide binding]; other site 999891004123 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 999891004124 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 999891004125 active site 999891004126 FMN binding site [chemical binding]; other site 999891004127 substrate binding site [chemical binding]; other site 999891004128 3Fe-4S cluster binding site [ion binding]; other site 999891004129 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 999891004130 domain interface; other site 999891004131 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 999891004132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 999891004133 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 999891004134 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 999891004135 NAD(P) binding site [chemical binding]; other site 999891004136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999891004137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999891004138 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 999891004139 putative dimerization interface [polypeptide binding]; other site 999891004140 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 999891004141 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 999891004142 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 999891004143 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 999891004144 active site 999891004145 dimer interface [polypeptide binding]; other site 999891004146 motif 1; other site 999891004147 motif 2; other site 999891004148 motif 3; other site 999891004149 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 999891004150 anticodon binding site; other site 999891004151 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891004152 dimerization interface [polypeptide binding]; other site 999891004153 putative DNA binding site [nucleotide binding]; other site 999891004154 putative Zn2+ binding site [ion binding]; other site 999891004155 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 999891004156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891004157 putative substrate translocation pore; other site 999891004158 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 999891004159 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 999891004160 Helix-turn-helix domain; Region: HTH_17; cl17695 999891004161 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 999891004162 Int/Topo IB signature motif; other site 999891004163 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 999891004164 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 999891004165 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 999891004166 active site 999891004167 catalytic residues [active] 999891004168 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 999891004169 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 999891004170 Condensation domain; Region: Condensation; pfam00668 999891004171 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891004172 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 999891004173 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891004174 acyl-activating enzyme (AAE) consensus motif; other site 999891004175 AMP binding site [chemical binding]; other site 999891004176 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004177 Condensation domain; Region: Condensation; pfam00668 999891004178 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891004179 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 999891004180 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891004181 acyl-activating enzyme (AAE) consensus motif; other site 999891004182 AMP binding site [chemical binding]; other site 999891004183 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004184 Condensation domain; Region: Condensation; pfam00668 999891004185 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 999891004186 Condensation domain; Region: Condensation; pfam00668 999891004187 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891004188 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 999891004189 acyl-activating enzyme (AAE) consensus motif; other site 999891004190 AMP binding site [chemical binding]; other site 999891004191 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004192 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 999891004193 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 999891004194 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 999891004195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 999891004196 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 999891004197 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 999891004198 FAD binding site [chemical binding]; other site 999891004199 homotetramer interface [polypeptide binding]; other site 999891004200 substrate binding pocket [chemical binding]; other site 999891004201 catalytic base [active] 999891004202 AMP-binding domain protein; Validated; Region: PRK08315 999891004203 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 999891004204 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 999891004205 acyl-activating enzyme (AAE) consensus motif; other site 999891004206 putative AMP binding site [chemical binding]; other site 999891004207 putative active site [active] 999891004208 putative CoA binding site [chemical binding]; other site 999891004209 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 999891004210 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 999891004211 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 999891004212 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 999891004213 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 999891004214 carboxyltransferase (CT) interaction site; other site 999891004215 biotinylation site [posttranslational modification]; other site 999891004216 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 999891004217 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 999891004218 active site 999891004219 catalytic residues [active] 999891004220 metal binding site [ion binding]; metal-binding site 999891004221 enoyl-CoA hydratase; Provisional; Region: PRK07657 999891004222 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 999891004223 substrate binding site [chemical binding]; other site 999891004224 oxyanion hole (OAH) forming residues; other site 999891004225 trimer interface [polypeptide binding]; other site 999891004226 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 999891004227 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 999891004228 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 999891004229 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 999891004230 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 999891004231 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 999891004232 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 999891004233 active site 999891004234 tetramer interface; other site 999891004235 Predicted membrane protein [Function unknown]; Region: COG2246 999891004236 GtrA-like protein; Region: GtrA; pfam04138 999891004237 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 999891004238 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 999891004239 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 999891004240 inhibitor-cofactor binding pocket; inhibition site 999891004241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891004242 catalytic residue [active] 999891004243 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 999891004244 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 999891004245 substrate-cofactor binding pocket; other site 999891004246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891004247 catalytic residue [active] 999891004248 AAA domain; Region: AAA_26; pfam13500 999891004249 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 999891004250 biotin synthase; Validated; Region: PRK06256 999891004251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 999891004252 FeS/SAM binding site; other site 999891004253 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 999891004254 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 999891004255 Cytochrome P450; Region: p450; cl12078 999891004256 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 999891004257 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 999891004258 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 999891004259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999891004260 NAD(P) binding site [chemical binding]; other site 999891004261 active site 999891004262 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 999891004263 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 999891004264 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 999891004265 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 999891004266 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 999891004267 acyl-activating enzyme (AAE) consensus motif; other site 999891004268 putative AMP binding site [chemical binding]; other site 999891004269 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004270 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 999891004271 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 999891004272 active site 999891004273 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004274 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 999891004275 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 999891004276 inhibitor-cofactor binding pocket; inhibition site 999891004277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891004278 catalytic residue [active] 999891004279 Condensation domain; Region: Condensation; pfam00668 999891004280 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891004281 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004282 Condensation domain; Region: Condensation; pfam00668 999891004283 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891004284 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 999891004285 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891004286 acyl-activating enzyme (AAE) consensus motif; other site 999891004287 AMP binding site [chemical binding]; other site 999891004288 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004289 Condensation domain; Region: Condensation; pfam00668 999891004290 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891004291 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 999891004292 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891004293 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 999891004294 acyl-activating enzyme (AAE) consensus motif; other site 999891004295 AMP binding site [chemical binding]; other site 999891004296 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004297 Condensation domain; Region: Condensation; pfam00668 999891004298 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891004299 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 999891004300 Condensation domain; Region: Condensation; pfam00668 999891004301 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891004302 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 999891004303 acyl-activating enzyme (AAE) consensus motif; other site 999891004304 AMP binding site [chemical binding]; other site 999891004305 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004306 Condensation domain; Region: Condensation; pfam00668 999891004307 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891004308 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 999891004309 Condensation domain; Region: Condensation; pfam00668 999891004310 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891004311 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891004312 acyl-activating enzyme (AAE) consensus motif; other site 999891004313 AMP binding site [chemical binding]; other site 999891004314 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004315 Condensation domain; Region: Condensation; pfam00668 999891004316 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891004317 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 999891004318 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891004319 acyl-activating enzyme (AAE) consensus motif; other site 999891004320 AMP binding site [chemical binding]; other site 999891004321 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004322 Condensation domain; Region: Condensation; pfam00668 999891004323 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891004324 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 999891004325 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891004326 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 999891004327 acyl-activating enzyme (AAE) consensus motif; other site 999891004328 AMP binding site [chemical binding]; other site 999891004329 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004330 Condensation domain; Region: Condensation; pfam00668 999891004331 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891004332 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 999891004333 Condensation domain; Region: Condensation; pfam00668 999891004334 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891004335 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891004336 acyl-activating enzyme (AAE) consensus motif; other site 999891004337 AMP binding site [chemical binding]; other site 999891004338 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004339 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 999891004340 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 999891004341 substrate binding site [chemical binding]; other site 999891004342 active site 999891004343 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 999891004344 metal binding site [ion binding]; metal-binding site 999891004345 ligand binding site [chemical binding]; other site 999891004346 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 999891004347 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 999891004348 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999891004349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891004350 active site 999891004351 phosphorylation site [posttranslational modification] 999891004352 intermolecular recognition site; other site 999891004353 dimerization interface [polypeptide binding]; other site 999891004354 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999891004355 DNA binding site [nucleotide binding] 999891004356 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999891004357 HAMP domain; Region: HAMP; pfam00672 999891004358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891004359 dimer interface [polypeptide binding]; other site 999891004360 phosphorylation site [posttranslational modification] 999891004361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891004362 ATP binding site [chemical binding]; other site 999891004363 Mg2+ binding site [ion binding]; other site 999891004364 G-X-G motif; other site 999891004365 YndJ-like protein; Region: YndJ; pfam14158 999891004366 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 999891004367 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 999891004368 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 999891004369 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 999891004370 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 999891004371 CAP-like domain; other site 999891004372 active site 999891004373 primary dimer interface [polypeptide binding]; other site 999891004374 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999891004375 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999891004376 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999891004377 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 999891004378 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 999891004379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891004380 ATP binding site [chemical binding]; other site 999891004381 Mg2+ binding site [ion binding]; other site 999891004382 G-X-G motif; other site 999891004383 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 999891004384 anchoring element; other site 999891004385 dimer interface [polypeptide binding]; other site 999891004386 ATP binding site [chemical binding]; other site 999891004387 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 999891004388 active site 999891004389 putative metal-binding site [ion binding]; other site 999891004390 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 999891004391 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 999891004392 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 999891004393 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 999891004394 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 999891004395 active site 999891004396 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 999891004397 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 999891004398 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 999891004399 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 999891004400 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 999891004401 catalytic residues [active] 999891004402 aconitate hydratase; Validated; Region: PRK09277 999891004403 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 999891004404 substrate binding site [chemical binding]; other site 999891004405 ligand binding site [chemical binding]; other site 999891004406 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 999891004407 substrate binding site [chemical binding]; other site 999891004408 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 999891004409 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 999891004410 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 999891004411 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 999891004412 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 999891004413 Response regulator receiver domain; Region: Response_reg; pfam00072 999891004414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891004415 active site 999891004416 phosphorylation site [posttranslational modification] 999891004417 intermolecular recognition site; other site 999891004418 dimerization interface [polypeptide binding]; other site 999891004419 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 999891004420 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 999891004421 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 999891004422 hypothetical protein; Provisional; Region: PRK01844 999891004423 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 999891004424 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 999891004425 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 999891004426 TPP-binding site [chemical binding]; other site 999891004427 dimer interface [polypeptide binding]; other site 999891004428 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 999891004429 PYR/PP interface [polypeptide binding]; other site 999891004430 dimer interface [polypeptide binding]; other site 999891004431 TPP binding site [chemical binding]; other site 999891004432 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 999891004433 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 999891004434 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 999891004435 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 999891004436 catalytic residues [active] 999891004437 catalytic nucleophile [active] 999891004438 cell division suppressor protein YneA; Provisional; Region: PRK14125 999891004439 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891004440 LexA repressor; Validated; Region: PRK00215 999891004441 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891004442 putative DNA binding site [nucleotide binding]; other site 999891004443 putative Zn2+ binding site [ion binding]; other site 999891004444 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 999891004445 Catalytic site [active] 999891004446 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 999891004447 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 999891004448 Protein of unknown function (DUF867); Region: DUF867; pfam05908 999891004449 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 999891004450 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 999891004451 trimer interface [polypeptide binding]; other site 999891004452 active site 999891004453 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 999891004454 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 999891004455 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 999891004456 Chitin binding domain; Region: Chitin_bind_3; pfam03067 999891004457 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 999891004458 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 999891004459 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 999891004460 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 999891004461 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 999891004462 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 999891004463 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 999891004464 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 999891004465 YoaP-like; Region: YoaP; pfam14268 999891004466 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 999891004467 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 999891004468 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 999891004469 NAD binding site [chemical binding]; other site 999891004470 substrate binding site [chemical binding]; other site 999891004471 catalytic Zn binding site [ion binding]; other site 999891004472 tetramer interface [polypeptide binding]; other site 999891004473 structural Zn binding site [ion binding]; other site 999891004474 DinB family; Region: DinB; cl17821 999891004475 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891004476 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 999891004477 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 999891004478 putative NAD(P) binding site [chemical binding]; other site 999891004479 catalytic Zn binding site [ion binding]; other site 999891004480 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 999891004481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891004482 phosphoenolpyruvate synthase; Validated; Region: PRK06241 999891004483 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 999891004484 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 999891004485 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 999891004486 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 999891004487 N- and C-terminal domain interface [polypeptide binding]; other site 999891004488 D-xylulose kinase; Region: XylB; TIGR01312 999891004489 active site 999891004490 MgATP binding site [chemical binding]; other site 999891004491 catalytic site [active] 999891004492 metal binding site [ion binding]; metal-binding site 999891004493 xylulose binding site [chemical binding]; other site 999891004494 homodimer interface [polypeptide binding]; other site 999891004495 xylose isomerase; Provisional; Region: PRK05474 999891004496 xylose isomerase; Region: xylose_isom_A; TIGR02630 999891004497 Transcriptional regulators [Transcription]; Region: MarR; COG1846 999891004498 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 999891004499 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 999891004500 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 999891004501 nucleotide binding site [chemical binding]; other site 999891004502 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 999891004503 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 999891004504 inhibitor binding site; inhibition site 999891004505 active site 999891004506 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 999891004507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891004508 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 999891004509 Cytochrome P450; Region: p450; cl12078 999891004510 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 999891004511 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 999891004512 glutamine synthetase, type I; Region: GlnA; TIGR00653 999891004513 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 999891004514 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 999891004515 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 999891004516 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 999891004517 DNA binding residues [nucleotide binding] 999891004518 putative dimer interface [polypeptide binding]; other site 999891004519 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 999891004520 Aluminium resistance protein; Region: Alum_res; pfam06838 999891004521 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 999891004522 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 999891004523 HflX GTPase family; Region: HflX; cd01878 999891004524 G1 box; other site 999891004525 GTP/Mg2+ binding site [chemical binding]; other site 999891004526 Switch I region; other site 999891004527 G2 box; other site 999891004528 G3 box; other site 999891004529 Switch II region; other site 999891004530 G4 box; other site 999891004531 G5 box; other site 999891004532 stage V sporulation protein K; Region: spore_V_K; TIGR02881 999891004533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891004534 Walker A motif; other site 999891004535 ATP binding site [chemical binding]; other site 999891004536 Walker B motif; other site 999891004537 arginine finger; other site 999891004538 potential frameshift: common BLAST hit: gi|308173701|ref|YP_003920406.1| N-acetylmuramoyl-L-alanine amidase; cwlC 999891004539 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 999891004540 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 999891004541 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 999891004542 dimer interface [polypeptide binding]; other site 999891004543 putative radical transfer pathway; other site 999891004544 diiron center [ion binding]; other site 999891004545 tyrosyl radical; other site 999891004546 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 999891004547 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 999891004548 Class I ribonucleotide reductase; Region: RNR_I; cd01679 999891004549 active site 999891004550 dimer interface [polypeptide binding]; other site 999891004551 catalytic residues [active] 999891004552 effector binding site; other site 999891004553 R2 peptide binding site; other site 999891004554 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 999891004555 YmzC-like protein; Region: YmzC; pfam14157 999891004556 bacterial Hfq-like; Region: Hfq; cd01716 999891004557 hexamer interface [polypeptide binding]; other site 999891004558 Sm1 motif; other site 999891004559 RNA binding site [nucleotide binding]; other site 999891004560 Sm2 motif; other site 999891004561 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 999891004562 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 999891004563 YmaF family; Region: YmaF; pfam12788 999891004564 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 999891004565 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 999891004566 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 999891004567 Protein of unknown function (DUF867); Region: DUF867; pfam05908 999891004568 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 999891004569 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 999891004570 active site 999891004571 catalytic triad [active] 999891004572 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 999891004573 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 999891004574 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 999891004575 Cytochrome P450; Region: p450; cl12078 999891004576 Methyltransferase domain; Region: Methyltransf_23; pfam13489 999891004577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891004578 S-adenosylmethionine binding site [chemical binding]; other site 999891004579 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 999891004580 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 999891004581 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 999891004582 active site 999891004583 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 999891004584 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 999891004585 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 999891004586 active site 999891004587 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004588 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 999891004589 Condensation domain; Region: Condensation; pfam00668 999891004590 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891004591 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 999891004592 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891004593 acyl-activating enzyme (AAE) consensus motif; other site 999891004594 AMP binding site [chemical binding]; other site 999891004595 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004596 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 999891004597 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 999891004598 active site 999891004599 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 999891004600 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 999891004601 putative NADP binding site [chemical binding]; other site 999891004602 KR domain; Region: KR; pfam08659 999891004603 active site 999891004604 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 999891004605 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 999891004606 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 999891004607 active site 999891004608 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 999891004609 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 999891004610 putative NADP binding site [chemical binding]; other site 999891004611 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 999891004612 active site 999891004613 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 999891004614 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 999891004615 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 999891004616 active site 999891004617 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 999891004618 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 999891004619 putative NADP binding site [chemical binding]; other site 999891004620 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 999891004621 active site 999891004622 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 999891004623 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004624 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 999891004625 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 999891004626 active site 999891004627 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 999891004628 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 999891004629 putative NADP binding site [chemical binding]; other site 999891004630 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 999891004631 active site 999891004632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891004633 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 999891004634 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 999891004635 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 999891004636 active site 999891004637 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 999891004638 putative NADP binding site [chemical binding]; other site 999891004639 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 999891004640 active site 999891004641 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004642 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 999891004643 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 999891004644 active site 999891004645 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 999891004646 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 999891004647 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 999891004648 putative NADP binding site [chemical binding]; other site 999891004649 active site 999891004650 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 999891004651 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 999891004652 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 999891004653 active site 999891004654 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 999891004655 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 999891004656 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 999891004657 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 999891004658 active site 999891004659 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 999891004660 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 999891004661 putative NADP binding site [chemical binding]; other site 999891004662 active site 999891004663 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004664 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 999891004665 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 999891004666 active site 999891004667 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 999891004668 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 999891004669 acyl-activating enzyme (AAE) consensus motif; other site 999891004670 putative AMP binding site [chemical binding]; other site 999891004671 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004672 Condensation domain; Region: Condensation; pfam00668 999891004673 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 999891004674 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 999891004675 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 999891004676 acyl-activating enzyme (AAE) consensus motif; other site 999891004677 AMP binding site [chemical binding]; other site 999891004678 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004679 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 999891004680 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 999891004681 active site 999891004682 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 999891004683 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 999891004684 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 999891004685 putative NADP binding site [chemical binding]; other site 999891004686 active site 999891004687 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 999891004688 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 999891004689 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 999891004690 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 999891004691 active site 999891004692 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 999891004693 putative NADP binding site [chemical binding]; other site 999891004694 active site 999891004695 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891004696 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 999891004697 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 999891004698 active site 999891004699 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 999891004700 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 999891004701 substrate binding site [chemical binding]; other site 999891004702 oxyanion hole (OAH) forming residues; other site 999891004703 trimer interface [polypeptide binding]; other site 999891004704 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 999891004705 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 999891004706 substrate binding site [chemical binding]; other site 999891004707 oxyanion hole (OAH) forming residues; other site 999891004708 trimer interface [polypeptide binding]; other site 999891004709 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 999891004710 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 999891004711 dimer interface [polypeptide binding]; other site 999891004712 active site 999891004713 acyl carrier protein; Validated; Region: PRK07117 999891004714 potential frameshift: common BLAST hit: gi|308173672|ref|YP_003920377.1| bacillaene synthesis; malonyl-CoA-[acyl-carrier protein]; baeE 999891004715 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 999891004716 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 999891004717 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 999891004718 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 999891004719 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 999891004720 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 999891004721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891004722 ATP binding site [chemical binding]; other site 999891004723 Mg2+ binding site [ion binding]; other site 999891004724 G-X-G motif; other site 999891004725 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 999891004726 ATP binding site [chemical binding]; other site 999891004727 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 999891004728 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 999891004729 MutS domain I; Region: MutS_I; pfam01624 999891004730 MutS domain II; Region: MutS_II; pfam05188 999891004731 MutS domain III; Region: MutS_III; pfam05192 999891004732 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 999891004733 Walker A/P-loop; other site 999891004734 ATP binding site [chemical binding]; other site 999891004735 Q-loop/lid; other site 999891004736 ABC transporter signature motif; other site 999891004737 Walker B; other site 999891004738 D-loop; other site 999891004739 H-loop/switch region; other site 999891004740 Outer spore coat protein E (CotE); Region: CotE; pfam10628 999891004741 Predicted membrane protein [Function unknown]; Region: COG4550 999891004742 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 999891004743 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 999891004744 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 999891004745 FeS/SAM binding site; other site 999891004746 TRAM domain; Region: TRAM; pfam01938 999891004747 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 999891004748 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 999891004749 substrate-cofactor binding pocket; other site 999891004750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891004751 catalytic residue [active] 999891004752 Threonine dehydrogenase; Region: TDH; cd05281 999891004753 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 999891004754 structural Zn binding site [ion binding]; other site 999891004755 catalytic Zn binding site [ion binding]; other site 999891004756 tetramer interface [polypeptide binding]; other site 999891004757 NADP binding site [chemical binding]; other site 999891004758 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 999891004759 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 999891004760 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 999891004761 putative active site [active] 999891004762 metal binding site [ion binding]; metal-binding site 999891004763 homodimer binding site [polypeptide binding]; other site 999891004764 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 999891004765 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 999891004766 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 999891004767 Zn2+ binding site [ion binding]; other site 999891004768 Mg2+ binding site [ion binding]; other site 999891004769 Beta-lactamase; Region: Beta-lactamase; pfam00144 999891004770 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 999891004771 recombinase A; Provisional; Region: recA; PRK09354 999891004772 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 999891004773 hexamer interface [polypeptide binding]; other site 999891004774 Walker A motif; other site 999891004775 ATP binding site [chemical binding]; other site 999891004776 Walker B motif; other site 999891004777 competence damage-inducible protein A; Provisional; Region: PRK00549 999891004778 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 999891004779 putative MPT binding site; other site 999891004780 Competence-damaged protein; Region: CinA; pfam02464 999891004781 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 999891004782 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 999891004783 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891004784 non-specific DNA binding site [nucleotide binding]; other site 999891004785 salt bridge; other site 999891004786 sequence-specific DNA binding site [nucleotide binding]; other site 999891004787 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 999891004788 ACT domain; Region: ACT; pfam01842 999891004789 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 999891004790 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 999891004791 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 999891004792 classical (c) SDRs; Region: SDR_c; cd05233 999891004793 NAD(P) binding site [chemical binding]; other site 999891004794 active site 999891004795 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 999891004796 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 999891004797 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 999891004798 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 999891004799 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 999891004800 MMPL family; Region: MMPL; pfam03176 999891004801 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 999891004802 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891004803 MarR family; Region: MarR_2; pfam12802 999891004804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891004805 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891004806 putative substrate translocation pore; other site 999891004807 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 999891004808 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891004809 DNA-binding site [nucleotide binding]; DNA binding site 999891004810 UTRA domain; Region: UTRA; pfam07702 999891004811 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 999891004812 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 999891004813 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 999891004814 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 999891004815 YlzJ-like protein; Region: YlzJ; pfam14035 999891004816 Clp protease; Region: CLP_protease; pfam00574 999891004817 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 999891004818 active site 999891004819 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 999891004820 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 999891004821 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 999891004822 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 999891004823 dihydrodipicolinate synthase; Region: dapA; TIGR00674 999891004824 dimer interface [polypeptide binding]; other site 999891004825 active site 999891004826 catalytic residue [active] 999891004827 aspartate kinase I; Reviewed; Region: PRK08210 999891004828 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 999891004829 putative catalytic residues [active] 999891004830 putative nucleotide binding site [chemical binding]; other site 999891004831 putative aspartate binding site [chemical binding]; other site 999891004832 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 999891004833 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 999891004834 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 999891004835 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 999891004836 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 999891004837 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 999891004838 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 999891004839 NAD binding site [chemical binding]; other site 999891004840 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 999891004841 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 999891004842 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 999891004843 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 999891004844 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 999891004845 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 999891004846 NodB motif; other site 999891004847 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 999891004848 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 999891004849 RNase E interface [polypeptide binding]; other site 999891004850 trimer interface [polypeptide binding]; other site 999891004851 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 999891004852 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 999891004853 RNase E interface [polypeptide binding]; other site 999891004854 trimer interface [polypeptide binding]; other site 999891004855 active site 999891004856 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 999891004857 putative nucleic acid binding region [nucleotide binding]; other site 999891004858 G-X-X-G motif; other site 999891004859 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 999891004860 RNA binding site [nucleotide binding]; other site 999891004861 domain interface; other site 999891004862 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 999891004863 16S/18S rRNA binding site [nucleotide binding]; other site 999891004864 S13e-L30e interaction site [polypeptide binding]; other site 999891004865 25S rRNA binding site [nucleotide binding]; other site 999891004866 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 999891004867 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 999891004868 active site 999891004869 Riboflavin kinase; Region: Flavokinase; smart00904 999891004870 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 999891004871 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 999891004872 RNA binding site [nucleotide binding]; other site 999891004873 active site 999891004874 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 999891004875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 999891004876 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 999891004877 translation initiation factor IF-2; Region: IF-2; TIGR00487 999891004878 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 999891004879 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 999891004880 G1 box; other site 999891004881 putative GEF interaction site [polypeptide binding]; other site 999891004882 GTP/Mg2+ binding site [chemical binding]; other site 999891004883 Switch I region; other site 999891004884 G2 box; other site 999891004885 G3 box; other site 999891004886 Switch II region; other site 999891004887 G4 box; other site 999891004888 G5 box; other site 999891004889 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 999891004890 Translation-initiation factor 2; Region: IF-2; pfam11987 999891004891 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 999891004892 hypothetical protein; Provisional; Region: PRK07714 999891004893 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 999891004894 putative RNA binding cleft [nucleotide binding]; other site 999891004895 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 999891004896 NusA N-terminal domain; Region: NusA_N; pfam08529 999891004897 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 999891004898 RNA binding site [nucleotide binding]; other site 999891004899 homodimer interface [polypeptide binding]; other site 999891004900 NusA-like KH domain; Region: KH_5; pfam13184 999891004901 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 999891004902 G-X-X-G motif; other site 999891004903 ribosome maturation protein RimP; Reviewed; Region: PRK00092 999891004904 Sm and related proteins; Region: Sm_like; cl00259 999891004905 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 999891004906 putative oligomer interface [polypeptide binding]; other site 999891004907 putative RNA binding site [nucleotide binding]; other site 999891004908 DNA polymerase III PolC; Validated; Region: polC; PRK00448 999891004909 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 999891004910 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 999891004911 generic binding surface II; other site 999891004912 generic binding surface I; other site 999891004913 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 999891004914 active site 999891004915 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 999891004916 active site 999891004917 catalytic site [active] 999891004918 substrate binding site [chemical binding]; other site 999891004919 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 999891004920 prolyl-tRNA synthetase; Provisional; Region: PRK09194 999891004921 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 999891004922 dimer interface [polypeptide binding]; other site 999891004923 motif 1; other site 999891004924 active site 999891004925 motif 2; other site 999891004926 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 999891004927 putative deacylase active site [active] 999891004928 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 999891004929 active site 999891004930 motif 3; other site 999891004931 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 999891004932 anticodon binding site; other site 999891004933 RIP metalloprotease RseP; Region: TIGR00054 999891004934 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 999891004935 active site 999891004936 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 999891004937 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 999891004938 protein binding site [polypeptide binding]; other site 999891004939 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 999891004940 putative substrate binding region [chemical binding]; other site 999891004941 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 999891004942 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 999891004943 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 999891004944 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 999891004945 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 999891004946 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 999891004947 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 999891004948 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 999891004949 catalytic residue [active] 999891004950 putative FPP diphosphate binding site; other site 999891004951 putative FPP binding hydrophobic cleft; other site 999891004952 dimer interface [polypeptide binding]; other site 999891004953 putative IPP diphosphate binding site; other site 999891004954 ribosome recycling factor; Reviewed; Region: frr; PRK00083 999891004955 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 999891004956 hinge region; other site 999891004957 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 999891004958 putative nucleotide binding site [chemical binding]; other site 999891004959 uridine monophosphate binding site [chemical binding]; other site 999891004960 homohexameric interface [polypeptide binding]; other site 999891004961 elongation factor Ts; Provisional; Region: tsf; PRK09377 999891004962 UBA/TS-N domain; Region: UBA; pfam00627 999891004963 Elongation factor TS; Region: EF_TS; pfam00889 999891004964 Elongation factor TS; Region: EF_TS; pfam00889 999891004965 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 999891004966 rRNA interaction site [nucleotide binding]; other site 999891004967 S8 interaction site; other site 999891004968 putative laminin-1 binding site; other site 999891004969 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 999891004970 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999891004971 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 999891004972 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999891004973 DNA binding residues [nucleotide binding] 999891004974 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 999891004975 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 999891004976 CheC-like family; Region: CheC; pfam04509 999891004977 CheC-like family; Region: CheC; pfam04509 999891004978 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 999891004979 putative CheA interaction surface; other site 999891004980 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 999891004981 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 999891004982 putative binding surface; other site 999891004983 active site 999891004984 P2 response regulator binding domain; Region: P2; pfam07194 999891004985 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 999891004986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891004987 ATP binding site [chemical binding]; other site 999891004988 Mg2+ binding site [ion binding]; other site 999891004989 G-X-G motif; other site 999891004990 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 999891004991 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 999891004992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891004993 active site 999891004994 phosphorylation site [posttranslational modification] 999891004995 intermolecular recognition site; other site 999891004996 dimerization interface [polypeptide binding]; other site 999891004997 CheB methylesterase; Region: CheB_methylest; pfam01339 999891004998 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 999891004999 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 999891005000 P-loop; other site 999891005001 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 999891005002 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 999891005003 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 999891005004 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 999891005005 FHIPEP family; Region: FHIPEP; pfam00771 999891005006 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 999891005007 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 999891005008 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 999891005009 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 999891005010 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 999891005011 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 999891005012 Response regulator receiver domain; Region: Response_reg; pfam00072 999891005013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891005014 active site 999891005015 phosphorylation site [posttranslational modification] 999891005016 intermolecular recognition site; other site 999891005017 dimerization interface [polypeptide binding]; other site 999891005018 flagellar motor switch protein; Validated; Region: PRK08119 999891005019 CheC-like family; Region: CheC; pfam04509 999891005020 CheC-like family; Region: CheC; pfam04509 999891005021 flagellar motor switch protein FliN; Region: fliN; TIGR02480 999891005022 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 999891005023 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 999891005024 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 999891005025 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 999891005026 Flagellar protein (FlbD); Region: FlbD; pfam06289 999891005027 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 999891005028 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 999891005029 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 999891005030 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 999891005031 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 999891005032 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 999891005033 Uncharacterized conserved protein [Function unknown]; Region: COG3334 999891005034 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 999891005035 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 999891005036 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 999891005037 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 999891005038 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 999891005039 Walker A motif/ATP binding site; other site 999891005040 Walker B motif; other site 999891005041 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 999891005042 Flagellar assembly protein FliH; Region: FliH; pfam02108 999891005043 flagellar motor switch protein FliG; Region: fliG; TIGR00207 999891005044 MgtE intracellular N domain; Region: MgtE_N; smart00924 999891005045 FliG C-terminal domain; Region: FliG_C; pfam01706 999891005046 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 999891005047 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 999891005048 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 999891005049 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 999891005050 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 999891005051 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 999891005052 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 999891005053 potential frameshift: common BLAST hit: gi|308173580|ref|YP_003920285.1| flagellar component of cell-proximal portion of basal-body rod; flgB 999891005054 transcriptional repressor CodY; Validated; Region: PRK04158 999891005055 CodY GAF-like domain; Region: CodY; pfam06018 999891005056 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 999891005057 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 999891005058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891005059 Walker A motif; other site 999891005060 ATP binding site [chemical binding]; other site 999891005061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 999891005062 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 999891005063 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 999891005064 active site 999891005065 HslU subunit interaction site [polypeptide binding]; other site 999891005066 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 999891005067 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 999891005068 active site 999891005069 Int/Topo IB signature motif; other site 999891005070 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 999891005071 Glucose inhibited division protein A; Region: GIDA; pfam01134 999891005072 DNA topoisomerase I; Validated; Region: PRK05582 999891005073 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 999891005074 active site 999891005075 interdomain interaction site; other site 999891005076 putative metal-binding site [ion binding]; other site 999891005077 nucleotide binding site [chemical binding]; other site 999891005078 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 999891005079 domain I; other site 999891005080 DNA binding groove [nucleotide binding] 999891005081 phosphate binding site [ion binding]; other site 999891005082 domain II; other site 999891005083 domain III; other site 999891005084 nucleotide binding site [chemical binding]; other site 999891005085 catalytic site [active] 999891005086 domain IV; other site 999891005087 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 999891005088 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 999891005089 DNA protecting protein DprA; Region: dprA; TIGR00732 999891005090 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 999891005091 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 999891005092 CoA binding domain; Region: CoA_binding; smart00881 999891005093 CoA-ligase; Region: Ligase_CoA; pfam00549 999891005094 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 999891005095 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 999891005096 CoA-ligase; Region: Ligase_CoA; pfam00549 999891005097 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 999891005098 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 999891005099 RNA/DNA hybrid binding site [nucleotide binding]; other site 999891005100 active site 999891005101 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 999891005102 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 999891005103 GTP/Mg2+ binding site [chemical binding]; other site 999891005104 G4 box; other site 999891005105 G5 box; other site 999891005106 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 999891005107 G1 box; other site 999891005108 G1 box; other site 999891005109 GTP/Mg2+ binding site [chemical binding]; other site 999891005110 Switch I region; other site 999891005111 G2 box; other site 999891005112 G2 box; other site 999891005113 G3 box; other site 999891005114 G3 box; other site 999891005115 Switch II region; other site 999891005116 Switch II region; other site 999891005117 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 999891005118 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 999891005119 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 999891005120 RimM N-terminal domain; Region: RimM; pfam01782 999891005121 PRC-barrel domain; Region: PRC; pfam05239 999891005122 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 999891005123 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 999891005124 KH domain; Region: KH_4; pfam13083 999891005125 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 999891005126 signal recognition particle protein; Provisional; Region: PRK10867 999891005127 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 999891005128 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 999891005129 P loop; other site 999891005130 GTP binding site [chemical binding]; other site 999891005131 Signal peptide binding domain; Region: SRP_SPB; pfam02978 999891005132 putative DNA-binding protein; Validated; Region: PRK00118 999891005133 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 999891005134 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 999891005135 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 999891005136 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 999891005137 GTP binding site [chemical binding]; other site 999891005138 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 999891005139 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 999891005140 Walker A/P-loop; other site 999891005141 ATP binding site [chemical binding]; other site 999891005142 Q-loop/lid; other site 999891005143 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 999891005144 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 999891005145 ABC transporter signature motif; other site 999891005146 Walker B; other site 999891005147 D-loop; other site 999891005148 H-loop/switch region; other site 999891005149 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 999891005150 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 999891005151 dimerization interface [polypeptide binding]; other site 999891005152 active site 999891005153 metal binding site [ion binding]; metal-binding site 999891005154 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 999891005155 dsRNA binding site [nucleotide binding]; other site 999891005156 acyl carrier protein; Provisional; Region: acpP; PRK00982 999891005157 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 999891005158 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 999891005159 NAD(P) binding site [chemical binding]; other site 999891005160 homotetramer interface [polypeptide binding]; other site 999891005161 homodimer interface [polypeptide binding]; other site 999891005162 active site 999891005163 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 999891005164 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 999891005165 putative phosphate acyltransferase; Provisional; Region: PRK05331 999891005166 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 999891005167 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 999891005168 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 999891005169 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 999891005170 generic binding surface II; other site 999891005171 ssDNA binding site; other site 999891005172 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999891005173 ATP binding site [chemical binding]; other site 999891005174 putative Mg++ binding site [ion binding]; other site 999891005175 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999891005176 nucleotide binding region [chemical binding]; other site 999891005177 ATP-binding site [chemical binding]; other site 999891005178 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 999891005179 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 999891005180 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 999891005181 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 999891005182 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 999891005183 putative L-serine binding site [chemical binding]; other site 999891005184 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 999891005185 DAK2 domain; Region: Dak2; pfam02734 999891005186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 999891005187 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 999891005188 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 999891005189 Thiamine pyrophosphokinase; Region: TPK; cd07995 999891005190 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 999891005191 active site 999891005192 dimerization interface [polypeptide binding]; other site 999891005193 thiamine binding site [chemical binding]; other site 999891005194 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 999891005195 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 999891005196 substrate binding site [chemical binding]; other site 999891005197 hexamer interface [polypeptide binding]; other site 999891005198 metal binding site [ion binding]; metal-binding site 999891005199 GTPase RsgA; Reviewed; Region: PRK00098 999891005200 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 999891005201 RNA binding site [nucleotide binding]; other site 999891005202 homodimer interface [polypeptide binding]; other site 999891005203 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 999891005204 GTPase/Zn-binding domain interface [polypeptide binding]; other site 999891005205 GTP/Mg2+ binding site [chemical binding]; other site 999891005206 G4 box; other site 999891005207 G5 box; other site 999891005208 G1 box; other site 999891005209 Switch I region; other site 999891005210 G2 box; other site 999891005211 G3 box; other site 999891005212 Switch II region; other site 999891005213 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 999891005214 Catalytic domain of Protein Kinases; Region: PKc; cd00180 999891005215 active site 999891005216 ATP binding site [chemical binding]; other site 999891005217 substrate binding site [chemical binding]; other site 999891005218 activation loop (A-loop); other site 999891005219 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 999891005220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 999891005221 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 999891005222 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 999891005223 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 999891005224 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 999891005225 Protein phosphatase 2C; Region: PP2C; pfam00481 999891005226 active site 999891005227 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 999891005228 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 999891005229 FeS/SAM binding site; other site 999891005230 16S rRNA methyltransferase B; Provisional; Region: PRK14902 999891005231 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 999891005232 putative RNA binding site [nucleotide binding]; other site 999891005233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891005234 S-adenosylmethionine binding site [chemical binding]; other site 999891005235 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 999891005236 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 999891005237 putative active site [active] 999891005238 substrate binding site [chemical binding]; other site 999891005239 putative cosubstrate binding site; other site 999891005240 catalytic site [active] 999891005241 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 999891005242 substrate binding site [chemical binding]; other site 999891005243 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 999891005244 active site 999891005245 catalytic residues [active] 999891005246 metal binding site [ion binding]; metal-binding site 999891005247 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 999891005248 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999891005249 ATP binding site [chemical binding]; other site 999891005250 putative Mg++ binding site [ion binding]; other site 999891005251 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999891005252 nucleotide binding region [chemical binding]; other site 999891005253 ATP-binding site [chemical binding]; other site 999891005254 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 999891005255 Flavoprotein; Region: Flavoprotein; pfam02441 999891005256 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 999891005257 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 999891005258 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 999891005259 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 999891005260 catalytic site [active] 999891005261 G-X2-G-X-G-K; other site 999891005262 hypothetical protein; Provisional; Region: PRK04323 999891005263 TIGR00255 family protein; Region: TIGR00255 999891005264 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 999891005265 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 999891005266 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 999891005267 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 999891005268 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999891005269 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 999891005270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891005271 motif II; other site 999891005272 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 999891005273 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 999891005274 Domain of unknown function (DUF814); Region: DUF814; pfam05670 999891005275 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 999891005276 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 999891005277 active site 999891005278 Na/Ca binding site [ion binding]; other site 999891005279 catalytic site [active] 999891005280 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 999891005281 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 999891005282 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 999891005283 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 999891005284 putative active site [active] 999891005285 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 999891005286 putative active site [active] 999891005287 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 999891005288 diphthine synthase; Region: dph5; TIGR00522 999891005289 active site 999891005290 SAM binding site [chemical binding]; other site 999891005291 homodimer interface [polypeptide binding]; other site 999891005292 AAA domain; Region: AAA_33; pfam13671 999891005293 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 999891005294 ligand-binding site [chemical binding]; other site 999891005295 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 999891005296 ATP-sulfurylase; Region: ATPS; cd00517 999891005297 active site 999891005298 HXXH motif; other site 999891005299 flexible loop; other site 999891005300 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 999891005301 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 999891005302 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 999891005303 Active Sites [active] 999891005304 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999891005305 active site 999891005306 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 999891005307 active site 999891005308 dimer interface [polypeptide binding]; other site 999891005309 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 999891005310 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 999891005311 heterodimer interface [polypeptide binding]; other site 999891005312 active site 999891005313 FMN binding site [chemical binding]; other site 999891005314 homodimer interface [polypeptide binding]; other site 999891005315 substrate binding site [chemical binding]; other site 999891005316 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 999891005317 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 999891005318 FAD binding pocket [chemical binding]; other site 999891005319 FAD binding motif [chemical binding]; other site 999891005320 phosphate binding motif [ion binding]; other site 999891005321 beta-alpha-beta structure motif; other site 999891005322 NAD binding pocket [chemical binding]; other site 999891005323 Iron coordination center [ion binding]; other site 999891005324 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 999891005325 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 999891005326 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 999891005327 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 999891005328 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 999891005329 ATP-grasp domain; Region: ATP-grasp_4; cl17255 999891005330 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 999891005331 IMP binding site; other site 999891005332 dimer interface [polypeptide binding]; other site 999891005333 interdomain contacts; other site 999891005334 partial ornithine binding site; other site 999891005335 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 999891005336 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 999891005337 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 999891005338 catalytic site [active] 999891005339 subunit interface [polypeptide binding]; other site 999891005340 dihydroorotase; Validated; Region: pyrC; PRK09357 999891005341 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 999891005342 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 999891005343 active site 999891005344 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 999891005345 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 999891005346 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 999891005347 uracil-xanthine permease; Region: ncs2; TIGR00801 999891005348 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 999891005349 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999891005350 active site 999891005351 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 999891005352 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999891005353 RNA binding surface [nucleotide binding]; other site 999891005354 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 999891005355 active site 999891005356 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 999891005357 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 999891005358 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 999891005359 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 999891005360 HIGH motif; other site 999891005361 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 999891005362 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 999891005363 active site 999891005364 KMSKS motif; other site 999891005365 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 999891005366 tRNA binding surface [nucleotide binding]; other site 999891005367 anticodon binding site; other site 999891005368 DivIVA protein; Region: DivIVA; pfam05103 999891005369 DivIVA domain; Region: DivI1A_domain; TIGR03544 999891005370 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 999891005371 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999891005372 RNA binding surface [nucleotide binding]; other site 999891005373 YGGT family; Region: YGGT; pfam02325 999891005374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 999891005375 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 999891005376 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 999891005377 catalytic residue [active] 999891005378 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 999891005379 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 999891005380 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 999891005381 acetylornithine deacetylase; Validated; Region: PRK08596 999891005382 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 999891005383 metal binding site [ion binding]; metal-binding site 999891005384 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 999891005385 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 999891005386 Walker A/P-loop; other site 999891005387 ATP binding site [chemical binding]; other site 999891005388 Q-loop/lid; other site 999891005389 ABC transporter signature motif; other site 999891005390 Walker B; other site 999891005391 D-loop; other site 999891005392 H-loop/switch region; other site 999891005393 sporulation sigma factor SigG; Reviewed; Region: PRK08215 999891005394 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999891005395 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 999891005396 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999891005397 DNA binding residues [nucleotide binding] 999891005398 sporulation sigma factor SigE; Reviewed; Region: PRK08301 999891005399 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999891005400 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999891005401 DNA binding residues [nucleotide binding] 999891005402 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 999891005403 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 999891005404 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 999891005405 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 999891005406 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 999891005407 active site 999891005408 catalytic triad [active] 999891005409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 999891005410 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 999891005411 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 999891005412 Cna protein B-type domain; Region: Cna_B_2; pfam13715 999891005413 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 999891005414 cell division protein FtsZ; Validated; Region: PRK09330 999891005415 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 999891005416 nucleotide binding site [chemical binding]; other site 999891005417 SulA interaction site; other site 999891005418 cell division protein FtsA; Region: ftsA; TIGR01174 999891005419 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 999891005420 nucleotide binding site [chemical binding]; other site 999891005421 Cell division protein FtsA; Region: FtsA; pfam14450 999891005422 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 999891005423 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 999891005424 Cell division protein FtsQ; Region: FtsQ; pfam03799 999891005425 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 999891005426 FAD binding domain; Region: FAD_binding_4; pfam01565 999891005427 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 999891005428 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 999891005429 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 999891005430 active site 999891005431 homodimer interface [polypeptide binding]; other site 999891005432 stage V sporulation protein E; Region: spoVE; TIGR02615 999891005433 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 999891005434 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 999891005435 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 999891005436 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 999891005437 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 999891005438 Mg++ binding site [ion binding]; other site 999891005439 putative catalytic motif [active] 999891005440 putative substrate binding site [chemical binding]; other site 999891005441 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 999891005442 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 999891005443 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 999891005444 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 999891005445 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 999891005446 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 999891005447 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 999891005448 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 999891005449 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 999891005450 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 999891005451 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 999891005452 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 999891005453 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 999891005454 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 999891005455 MraW methylase family; Region: Methyltransf_5; pfam01795 999891005456 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 999891005457 mraZ protein; Region: TIGR00242 999891005458 MraZ protein; Region: MraZ; pfam02381 999891005459 MraZ protein; Region: MraZ; pfam02381 999891005460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 999891005461 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 999891005462 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 999891005463 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 999891005464 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 999891005465 hypothetical protein; Provisional; Region: PRK13688 999891005466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891005467 Coenzyme A binding pocket [chemical binding]; other site 999891005468 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 999891005469 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 999891005470 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 999891005471 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 999891005472 hypothetical protein; Provisional; Region: PRK13670 999891005473 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 999891005474 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 999891005475 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 999891005476 protein binding site [polypeptide binding]; other site 999891005477 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 999891005478 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 999891005479 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 999891005480 active site 999891005481 nucleophile elbow; other site 999891005482 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 999891005483 Nucleoside recognition; Region: Gate; pfam07670 999891005484 Nucleoside recognition; Region: Gate; pfam07670 999891005485 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 999891005486 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 999891005487 active site 999891005488 (T/H)XGH motif; other site 999891005489 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 999891005490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891005491 S-adenosylmethionine binding site [chemical binding]; other site 999891005492 hypothetical protein; Provisional; Region: PRK02886 999891005493 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 999891005494 YlbE-like protein; Region: YlbE; pfam14003 999891005495 Putative coat protein; Region: YlbD_coat; pfam14071 999891005496 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 999891005497 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 999891005498 FOG: CBS domain [General function prediction only]; Region: COG0517 999891005499 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 999891005500 YugN-like family; Region: YugN; pfam08868 999891005501 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 999891005502 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 999891005503 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 999891005504 Subunit I/III interface [polypeptide binding]; other site 999891005505 Subunit III/IV interface [polypeptide binding]; other site 999891005506 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 999891005507 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 999891005508 D-pathway; other site 999891005509 Putative ubiquinol binding site [chemical binding]; other site 999891005510 Low-spin heme (heme b) binding site [chemical binding]; other site 999891005511 Putative water exit pathway; other site 999891005512 Binuclear center (heme o3/CuB) [ion binding]; other site 999891005513 K-pathway; other site 999891005514 Putative proton exit pathway; other site 999891005515 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 999891005516 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 999891005517 Cytochrome c; Region: Cytochrom_C; pfam00034 999891005518 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 999891005519 UbiA prenyltransferase family; Region: UbiA; pfam01040 999891005520 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 999891005521 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 999891005522 pyruvate carboxylase; Reviewed; Region: PRK12999 999891005523 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 999891005524 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 999891005525 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 999891005526 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 999891005527 active site 999891005528 catalytic residues [active] 999891005529 metal binding site [ion binding]; metal-binding site 999891005530 homodimer binding site [polypeptide binding]; other site 999891005531 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 999891005532 carboxyltransferase (CT) interaction site; other site 999891005533 biotinylation site [posttranslational modification]; other site 999891005534 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 999891005535 hypothetical protein; Provisional; Region: PRK13666 999891005536 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 999891005537 glutaminase A; Region: Gln_ase; TIGR03814 999891005538 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 999891005539 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 999891005540 putative active site [active] 999891005541 PhoH-like protein; Region: PhoH; pfam02562 999891005542 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 999891005543 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 999891005544 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 999891005545 YlaH-like protein; Region: YlaH; pfam14036 999891005546 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 999891005547 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 999891005548 G1 box; other site 999891005549 putative GEF interaction site [polypeptide binding]; other site 999891005550 GTP/Mg2+ binding site [chemical binding]; other site 999891005551 Switch I region; other site 999891005552 G2 box; other site 999891005553 G3 box; other site 999891005554 Switch II region; other site 999891005555 G4 box; other site 999891005556 G5 box; other site 999891005557 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 999891005558 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 999891005559 Putative zinc-finger; Region: zf-HC2; pfam13490 999891005560 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 999891005561 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 999891005562 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 999891005563 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 999891005564 active site 999891005565 Zn binding site [ion binding]; other site 999891005566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891005567 Coenzyme A binding pocket [chemical binding]; other site 999891005568 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 999891005569 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 999891005570 active site 999891005571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 999891005572 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 999891005573 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 999891005574 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 999891005575 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 999891005576 homodimer interface [polypeptide binding]; other site 999891005577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891005578 catalytic residue [active] 999891005579 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 999891005580 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 999891005581 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 999891005582 NodB motif; other site 999891005583 active site 999891005584 catalytic site [active] 999891005585 metal binding site [ion binding]; metal-binding site 999891005586 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 999891005587 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 999891005588 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999891005589 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 999891005590 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 999891005591 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 999891005592 E3 interaction surface; other site 999891005593 lipoyl attachment site [posttranslational modification]; other site 999891005594 e3 binding domain; Region: E3_binding; pfam02817 999891005595 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 999891005596 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 999891005597 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 999891005598 alpha subunit interface [polypeptide binding]; other site 999891005599 TPP binding site [chemical binding]; other site 999891005600 heterodimer interface [polypeptide binding]; other site 999891005601 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 999891005602 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 999891005603 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 999891005604 TPP-binding site [chemical binding]; other site 999891005605 tetramer interface [polypeptide binding]; other site 999891005606 heterodimer interface [polypeptide binding]; other site 999891005607 phosphorylation loop region [posttranslational modification] 999891005608 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 999891005609 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 999891005610 active site 999891005611 catalytic residues [active] 999891005612 metal binding site [ion binding]; metal-binding site 999891005613 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 999891005614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891005615 active site 999891005616 motif I; other site 999891005617 motif II; other site 999891005618 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891005619 hypothetical protein; Provisional; Region: PRK13667 999891005620 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 999891005621 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 999891005622 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 999891005623 adenine deaminase; Region: ade; TIGR01178 999891005624 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 999891005625 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 999891005626 active site 999891005627 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 999891005628 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 999891005629 TrkA-N domain; Region: TrkA_N; pfam02254 999891005630 TrkA-C domain; Region: TrkA_C; pfam02080 999891005631 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 999891005632 putative active site pocket [active] 999891005633 dimerization interface [polypeptide binding]; other site 999891005634 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 999891005635 putative active site pocket [active] 999891005636 dimerization interface [polypeptide binding]; other site 999891005637 putative catalytic residue [active] 999891005638 PAS fold; Region: PAS; pfam00989 999891005639 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 999891005640 putative active site [active] 999891005641 heme pocket [chemical binding]; other site 999891005642 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999891005643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891005644 dimer interface [polypeptide binding]; other site 999891005645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891005646 ATP binding site [chemical binding]; other site 999891005647 Mg2+ binding site [ion binding]; other site 999891005648 G-X-G motif; other site 999891005649 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 999891005650 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 999891005651 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 999891005652 rod-share determining protein MreBH; Provisional; Region: PRK13929 999891005653 MreB and similar proteins; Region: MreB_like; cd10225 999891005654 nucleotide binding site [chemical binding]; other site 999891005655 Mg binding site [ion binding]; other site 999891005656 putative protofilament interaction site [polypeptide binding]; other site 999891005657 RodZ interaction site [polypeptide binding]; other site 999891005658 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 999891005659 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 999891005660 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 999891005661 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 999891005662 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 999891005663 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 999891005664 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999891005665 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999891005666 ABC transporter; Region: ABC_tran_2; pfam12848 999891005667 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 999891005668 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 999891005669 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 999891005670 Catalytic site [active] 999891005671 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 999891005672 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999891005673 active site 999891005674 phosphorylation site [posttranslational modification] 999891005675 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 999891005676 active site 999891005677 P-loop; other site 999891005678 phosphorylation site [posttranslational modification] 999891005679 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 999891005680 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 999891005681 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 999891005682 putative substrate binding site [chemical binding]; other site 999891005683 putative ATP binding site [chemical binding]; other site 999891005684 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 999891005685 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 999891005686 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 999891005687 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 999891005688 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 999891005689 FtsX-like permease family; Region: FtsX; pfam02687 999891005690 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999891005691 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 999891005692 Walker A/P-loop; other site 999891005693 ATP binding site [chemical binding]; other site 999891005694 Q-loop/lid; other site 999891005695 ABC transporter signature motif; other site 999891005696 Walker B; other site 999891005697 D-loop; other site 999891005698 H-loop/switch region; other site 999891005699 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 999891005700 HlyD family secretion protein; Region: HlyD_3; pfam13437 999891005701 Yip1 domain; Region: Yip1; pfam04893 999891005702 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 999891005703 MoaE interaction surface [polypeptide binding]; other site 999891005704 MoeB interaction surface [polypeptide binding]; other site 999891005705 thiocarboxylated glycine; other site 999891005706 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 999891005707 MoaE homodimer interface [polypeptide binding]; other site 999891005708 MoaD interaction [polypeptide binding]; other site 999891005709 active site residues [active] 999891005710 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 999891005711 Walker A motif; other site 999891005712 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 999891005713 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 999891005714 dimer interface [polypeptide binding]; other site 999891005715 putative functional site; other site 999891005716 putative MPT binding site; other site 999891005717 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 999891005718 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 999891005719 ATP binding site [chemical binding]; other site 999891005720 substrate interface [chemical binding]; other site 999891005721 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 999891005722 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 999891005723 GTP binding site; other site 999891005724 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 999891005725 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 999891005726 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 999891005727 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 999891005728 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 999891005729 Mechanosensitive ion channel; Region: MS_channel; pfam00924 999891005730 hypothetical protein; Provisional; Region: PRK03094 999891005731 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 999891005732 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 999891005733 metal binding site [ion binding]; metal-binding site 999891005734 putative dimer interface [polypeptide binding]; other site 999891005735 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 999891005736 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 999891005737 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 999891005738 active site 999891005739 trimer interface [polypeptide binding]; other site 999891005740 substrate binding site [chemical binding]; other site 999891005741 CoA binding site [chemical binding]; other site 999891005742 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 999891005743 flavodoxin, short chain; Region: flav_short; TIGR01753 999891005744 BNR repeat-like domain; Region: BNR_2; pfam13088 999891005745 flavodoxin; Provisional; Region: PRK06703 999891005746 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999891005747 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999891005748 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 999891005749 dimerization interface [polypeptide binding]; other site 999891005750 FOG: CBS domain [General function prediction only]; Region: COG0517 999891005751 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 999891005752 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 999891005753 Protein of unknown function (DUF458); Region: DUF458; pfam04308 999891005754 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 999891005755 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 999891005756 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 999891005757 short chain dehydrogenase; Provisional; Region: PRK07677 999891005758 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 999891005759 NAD(P) binding site [chemical binding]; other site 999891005760 substrate binding site [chemical binding]; other site 999891005761 homotetramer interface [polypeptide binding]; other site 999891005762 active site 999891005763 homodimer interface [polypeptide binding]; other site 999891005764 phosphodiesterase YaeI; Provisional; Region: PRK11340 999891005765 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 999891005766 putative active site [active] 999891005767 putative metal binding site [ion binding]; other site 999891005768 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891005769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 999891005770 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 999891005771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891005772 H+ Antiporter protein; Region: 2A0121; TIGR00900 999891005773 putative substrate translocation pore; other site 999891005774 YkyB-like protein; Region: YkyB; pfam14177 999891005775 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 999891005776 putative CheA interaction surface; other site 999891005777 Response regulator receiver domain; Region: Response_reg; pfam00072 999891005778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891005779 active site 999891005780 phosphorylation site [posttranslational modification] 999891005781 intermolecular recognition site; other site 999891005782 dimerization interface [polypeptide binding]; other site 999891005783 aminotransferase A; Validated; Region: PRK07683 999891005784 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891005785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891005786 homodimer interface [polypeptide binding]; other site 999891005787 catalytic residue [active] 999891005788 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 999891005789 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 999891005790 putative active site [active] 999891005791 heme pocket [chemical binding]; other site 999891005792 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 999891005793 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 999891005794 putative active site [active] 999891005795 heme pocket [chemical binding]; other site 999891005796 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 999891005797 putative active site [active] 999891005798 heme pocket [chemical binding]; other site 999891005799 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891005800 dimer interface [polypeptide binding]; other site 999891005801 phosphorylation site [posttranslational modification] 999891005802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891005803 ATP binding site [chemical binding]; other site 999891005804 Mg2+ binding site [ion binding]; other site 999891005805 G-X-G motif; other site 999891005806 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 999891005807 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 999891005808 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 999891005809 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 999891005810 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 999891005811 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 999891005812 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 999891005813 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 999891005814 Cache domain; Region: Cache_1; pfam02743 999891005815 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 999891005816 dimerization interface [polypeptide binding]; other site 999891005817 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 999891005818 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 999891005819 dimer interface [polypeptide binding]; other site 999891005820 putative CheW interface [polypeptide binding]; other site 999891005821 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 999891005822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 999891005823 FeS/SAM binding site; other site 999891005824 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 999891005825 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 999891005826 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 999891005827 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 999891005828 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 999891005829 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 999891005830 dimerization domain swap beta strand [polypeptide binding]; other site 999891005831 regulatory protein interface [polypeptide binding]; other site 999891005832 active site 999891005833 regulatory phosphorylation site [posttranslational modification]; other site 999891005834 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 999891005835 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 999891005836 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 999891005837 active site turn [active] 999891005838 phosphorylation site [posttranslational modification] 999891005839 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 999891005840 HPr interaction site; other site 999891005841 glycerol kinase (GK) interaction site [polypeptide binding]; other site 999891005842 active site 999891005843 phosphorylation site [posttranslational modification] 999891005844 CAT RNA binding domain; Region: CAT_RBD; pfam03123 999891005845 transcriptional antiterminator BglG; Provisional; Region: PRK09772 999891005846 PRD domain; Region: PRD; pfam00874 999891005847 PRD domain; Region: PRD; pfam00874 999891005848 Transcriptional regulators [Transcription]; Region: PurR; COG1609 999891005849 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999891005850 DNA binding site [nucleotide binding] 999891005851 domain linker motif; other site 999891005852 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 999891005853 putative dimerization interface [polypeptide binding]; other site 999891005854 putative ligand binding site [chemical binding]; other site 999891005855 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 999891005856 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 999891005857 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 999891005858 active site 999891005859 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 999891005860 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999891005861 Soluble P-type ATPase [General function prediction only]; Region: COG4087 999891005862 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 999891005863 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 999891005864 catalytic residues [active] 999891005865 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 999891005866 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 999891005867 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 999891005868 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 999891005869 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 999891005870 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 999891005871 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 999891005872 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 999891005873 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 999891005874 active site 999891005875 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 999891005876 Ligand Binding Site [chemical binding]; other site 999891005877 Uncharacterized membrane protein [Function unknown]; Region: COG3949 999891005878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891005879 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 999891005880 Walker A motif; other site 999891005881 ATP binding site [chemical binding]; other site 999891005882 Walker B motif; other site 999891005883 arginine finger; other site 999891005884 UvrB/uvrC motif; Region: UVR; pfam02151 999891005885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891005886 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 999891005887 Walker A motif; other site 999891005888 ATP binding site [chemical binding]; other site 999891005889 Walker B motif; other site 999891005890 arginine finger; other site 999891005891 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 999891005892 flagellar motor protein MotA; Validated; Region: PRK08124 999891005893 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 999891005894 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 999891005895 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 999891005896 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 999891005897 ligand binding site [chemical binding]; other site 999891005898 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891005899 MarR family; Region: MarR; pfam01047 999891005900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891005901 dimer interface [polypeptide binding]; other site 999891005902 phosphorylation site [posttranslational modification] 999891005903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891005904 ATP binding site [chemical binding]; other site 999891005905 Mg2+ binding site [ion binding]; other site 999891005906 G-X-G motif; other site 999891005907 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 999891005908 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 999891005909 Cupin domain; Region: Cupin_2; pfam07883 999891005910 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 999891005911 intersubunit interface [polypeptide binding]; other site 999891005912 active site 999891005913 Zn2+ binding site [ion binding]; other site 999891005914 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 999891005915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891005916 motif II; other site 999891005917 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 999891005918 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 999891005919 dimer interface [polypeptide binding]; other site 999891005920 active site 999891005921 catalytic residue [active] 999891005922 metal binding site [ion binding]; metal-binding site 999891005923 transaminase; Reviewed; Region: PRK08068 999891005924 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891005925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891005926 homodimer interface [polypeptide binding]; other site 999891005927 catalytic residue [active] 999891005928 Predicted amidohydrolase [General function prediction only]; Region: COG0388 999891005929 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 999891005930 putative active site [active] 999891005931 catalytic triad [active] 999891005932 putative dimer interface [polypeptide binding]; other site 999891005933 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 999891005934 Phosphotransferase enzyme family; Region: APH; pfam01636 999891005935 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 999891005936 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 999891005937 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 999891005938 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 999891005939 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 999891005940 DNA binding site [nucleotide binding] 999891005941 active site 999891005942 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 999891005943 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 999891005944 putative active site [active] 999891005945 heme pocket [chemical binding]; other site 999891005946 PAS domain; Region: PAS; smart00091 999891005947 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 999891005948 PAS domain; Region: PAS; smart00091 999891005949 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 999891005950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891005951 dimer interface [polypeptide binding]; other site 999891005952 phosphorylation site [posttranslational modification] 999891005953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891005954 ATP binding site [chemical binding]; other site 999891005955 Mg2+ binding site [ion binding]; other site 999891005956 G-X-G motif; other site 999891005957 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 999891005958 Acyltransferase family; Region: Acyl_transf_3; pfam01757 999891005959 Predicted membrane protein [Function unknown]; Region: COG2323 999891005960 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 999891005961 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 999891005962 heat shock protein HtpX; Provisional; Region: PRK05457 999891005963 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 999891005964 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 999891005965 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 999891005966 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 999891005967 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999891005968 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 999891005969 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 999891005970 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 999891005971 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 999891005972 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 999891005973 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 999891005974 PAS domain; Region: PAS_9; pfam13426 999891005975 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 999891005976 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 999891005977 metal binding site [ion binding]; metal-binding site 999891005978 active site 999891005979 I-site; other site 999891005980 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 999891005981 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 999891005982 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 999891005983 putative DNA binding site [nucleotide binding]; other site 999891005984 putative homodimer interface [polypeptide binding]; other site 999891005985 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 999891005986 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 999891005987 active site 999891005988 DNA binding site [nucleotide binding] 999891005989 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 999891005990 nucleotide binding site [chemical binding]; other site 999891005991 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891005992 MarR family; Region: MarR; pfam01047 999891005993 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 999891005994 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 999891005995 DNA binding residues [nucleotide binding] 999891005996 putative dimer interface [polypeptide binding]; other site 999891005997 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 999891005998 MgtE intracellular N domain; Region: MgtE_N; smart00924 999891005999 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 999891006000 Divalent cation transporter; Region: MgtE; pfam01769 999891006001 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 999891006002 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 999891006003 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891006004 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891006005 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 999891006006 active site 999891006007 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 999891006008 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 999891006009 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 999891006010 Walker A/P-loop; other site 999891006011 ATP binding site [chemical binding]; other site 999891006012 Q-loop/lid; other site 999891006013 ABC transporter signature motif; other site 999891006014 Walker B; other site 999891006015 D-loop; other site 999891006016 H-loop/switch region; other site 999891006017 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 999891006018 Walker A/P-loop; other site 999891006019 ATP binding site [chemical binding]; other site 999891006020 Q-loop/lid; other site 999891006021 ABC transporter signature motif; other site 999891006022 Walker B; other site 999891006023 D-loop; other site 999891006024 H-loop/switch region; other site 999891006025 Cobalt transport protein; Region: CbiQ; pfam02361 999891006026 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 999891006027 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 999891006028 active site 999891006029 catalytic residues [active] 999891006030 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 999891006031 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 999891006032 THF binding site; other site 999891006033 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 999891006034 substrate binding site [chemical binding]; other site 999891006035 THF binding site; other site 999891006036 zinc-binding site [ion binding]; other site 999891006037 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 999891006038 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 999891006039 ligand binding site [chemical binding]; other site 999891006040 flexible hinge region; other site 999891006041 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 999891006042 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 999891006043 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 999891006044 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 999891006045 putative metal binding site; other site 999891006046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891006047 binding surface 999891006048 TPR motif; other site 999891006049 TPR repeat; Region: TPR_11; pfam13414 999891006050 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 999891006051 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891006052 MarR family; Region: MarR; pfam01047 999891006053 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 999891006054 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 999891006055 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 999891006056 putative catalytic cysteine [active] 999891006057 gamma-glutamyl kinase; Provisional; Region: PRK05429 999891006058 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 999891006059 nucleotide binding site [chemical binding]; other site 999891006060 homotetrameric interface [polypeptide binding]; other site 999891006061 putative phosphate binding site [ion binding]; other site 999891006062 putative allosteric binding site; other site 999891006063 PUA domain; Region: PUA; pfam01472 999891006064 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 999891006065 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 999891006066 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 999891006067 putative active site [active] 999891006068 putative substrate binding site [chemical binding]; other site 999891006069 putative cosubstrate binding site; other site 999891006070 catalytic site [active] 999891006071 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 999891006072 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 999891006073 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 999891006074 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 999891006075 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 999891006076 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 999891006077 Amidinotransferase; Region: Amidinotransf; pfam02274 999891006078 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 999891006079 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 999891006080 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 999891006081 Walker A/P-loop; other site 999891006082 ATP binding site [chemical binding]; other site 999891006083 Q-loop/lid; other site 999891006084 ABC transporter signature motif; other site 999891006085 Walker B; other site 999891006086 D-loop; other site 999891006087 H-loop/switch region; other site 999891006088 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 999891006089 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 999891006090 NlpC/P60 family; Region: NLPC_P60; pfam00877 999891006091 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 999891006092 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 999891006093 active site 999891006094 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 999891006095 dimer interface [polypeptide binding]; other site 999891006096 catalytic triad [active] 999891006097 potential frameshift: common BLAST hit: gi|308173275|ref|YP_003919980.1| dipeptide ABC transporter (dipeptide-binding lipoprotein) 999891006098 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 999891006099 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 999891006100 Walker A/P-loop; other site 999891006101 ATP binding site [chemical binding]; other site 999891006102 Q-loop/lid; other site 999891006103 ABC transporter signature motif; other site 999891006104 Walker B; other site 999891006105 D-loop; other site 999891006106 H-loop/switch region; other site 999891006107 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 999891006108 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 999891006109 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 999891006110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891006111 dimer interface [polypeptide binding]; other site 999891006112 conserved gate region; other site 999891006113 putative PBP binding loops; other site 999891006114 ABC-ATPase subunit interface; other site 999891006115 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 999891006116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891006117 dimer interface [polypeptide binding]; other site 999891006118 conserved gate region; other site 999891006119 putative PBP binding loops; other site 999891006120 ABC-ATPase subunit interface; other site 999891006121 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 999891006122 SxDxEG motif; other site 999891006123 active site 999891006124 metal binding site [ion binding]; metal-binding site 999891006125 homopentamer interface [polypeptide binding]; other site 999891006126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891006127 putative substrate translocation pore; other site 999891006128 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891006129 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 999891006130 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 999891006131 protein binding site [polypeptide binding]; other site 999891006132 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 999891006133 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 999891006134 Ligand binding site; other site 999891006135 Putative Catalytic site; other site 999891006136 DXD motif; other site 999891006137 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 999891006138 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 999891006139 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 999891006140 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 999891006141 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 999891006142 Zn binding site [ion binding]; other site 999891006143 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 999891006144 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 999891006145 Zn binding site [ion binding]; other site 999891006146 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 999891006147 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 999891006148 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 999891006149 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 999891006150 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 999891006151 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 999891006152 amidase catalytic site [active] 999891006153 Zn binding residues [ion binding]; other site 999891006154 substrate binding site [chemical binding]; other site 999891006155 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891006156 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 999891006157 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 999891006158 Phage lysis protein, holin; Region: Phage_holin; pfam04688 999891006159 Haemolysin XhlA; Region: XhlA; pfam10779 999891006160 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 999891006161 XkdW protein; Region: XkdW; pfam09636 999891006162 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 999891006163 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 999891006164 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 999891006165 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 999891006166 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 999891006167 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891006168 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 999891006169 AAA ATPase domain; Region: AAA_15; pfam13175 999891006170 membrane protein P6; Region: PHA01399 999891006171 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 999891006172 N-acetyl-D-glucosamine binding site [chemical binding]; other site 999891006173 catalytic residue [active] 999891006174 Phage XkdN-like protein; Region: XkdN; pfam08890 999891006175 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 999891006176 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 999891006177 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 999891006178 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 999891006179 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 999891006180 Phage capsid family; Region: Phage_capsid; pfam05065 999891006181 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 999891006182 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 999891006183 Phage terminase small subunit; Region: Phage_terminase; pfam10668 999891006184 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 999891006185 positive control sigma-like factor; Validated; Region: PRK06930 999891006186 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999891006187 DNA binding residues [nucleotide binding] 999891006188 hypothetical protein; Provisional; Region: PRK06921 999891006189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891006190 Walker A motif; other site 999891006191 ATP binding site [chemical binding]; other site 999891006192 Walker B motif; other site 999891006193 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999891006194 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891006195 non-specific DNA binding site [nucleotide binding]; other site 999891006196 salt bridge; other site 999891006197 sequence-specific DNA binding site [nucleotide binding]; other site 999891006198 Domain of unknown function (DUF955); Region: DUF955; pfam06114 999891006199 Protein of unknown function (DUF867); Region: DUF867; pfam05908 999891006200 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 999891006201 pentamer interface [polypeptide binding]; other site 999891006202 dodecaamer interface [polypeptide binding]; other site 999891006203 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 999891006204 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 999891006205 amidase catalytic site [active] 999891006206 Zn binding residues [ion binding]; other site 999891006207 substrate binding site [chemical binding]; other site 999891006208 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 999891006209 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891006210 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 999891006211 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 999891006212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891006213 binding surface 999891006214 TPR motif; other site 999891006215 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891006216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 999891006217 binding surface 999891006218 TPR motif; other site 999891006219 DinB family; Region: DinB; cl17821 999891006220 DinB superfamily; Region: DinB_2; pfam12867 999891006221 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 999891006222 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999891006223 HAMP domain; Region: HAMP; pfam00672 999891006224 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891006225 dimer interface [polypeptide binding]; other site 999891006226 phosphorylation site [posttranslational modification] 999891006227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891006228 ATP binding site [chemical binding]; other site 999891006229 Mg2+ binding site [ion binding]; other site 999891006230 G-X-G motif; other site 999891006231 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999891006232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891006233 active site 999891006234 phosphorylation site [posttranslational modification] 999891006235 intermolecular recognition site; other site 999891006236 dimerization interface [polypeptide binding]; other site 999891006237 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999891006238 DNA binding site [nucleotide binding] 999891006239 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 999891006240 altronate oxidoreductase; Provisional; Region: PRK03643 999891006241 Transcriptional regulators [Transcription]; Region: PurR; COG1609 999891006242 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999891006243 DNA binding site [nucleotide binding] 999891006244 domain linker motif; other site 999891006245 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 999891006246 dimerization interface [polypeptide binding]; other site 999891006247 ligand binding site [chemical binding]; other site 999891006248 Glucuronate isomerase; Region: UxaC; cl00829 999891006249 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 999891006250 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 999891006251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999891006252 Uncharacterized conserved protein [Function unknown]; Region: COG2427 999891006253 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 999891006254 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 999891006255 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 999891006256 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 999891006257 Walker A/P-loop; other site 999891006258 ATP binding site [chemical binding]; other site 999891006259 Q-loop/lid; other site 999891006260 ABC transporter signature motif; other site 999891006261 Walker B; other site 999891006262 D-loop; other site 999891006263 H-loop/switch region; other site 999891006264 TIGR00245 family protein; Region: TIGR00245 999891006265 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 999891006266 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 999891006267 active site 999891006268 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 999891006269 glycosyltransferase, MGT family; Region: MGT; TIGR01426 999891006270 active site 999891006271 TDP-binding site; other site 999891006272 acceptor substrate-binding pocket; other site 999891006273 homodimer interface [polypeptide binding]; other site 999891006274 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 999891006275 Cytochrome P450; Region: p450; cl12078 999891006276 Uncharacterized conserved protein [Function unknown]; Region: COG2427 999891006277 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 999891006278 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 999891006279 catalytic loop [active] 999891006280 iron binding site [ion binding]; other site 999891006281 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 999891006282 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 999891006283 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 999891006284 [4Fe-4S] binding site [ion binding]; other site 999891006285 molybdopterin cofactor binding site; other site 999891006286 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 999891006287 molybdopterin cofactor binding site; other site 999891006288 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 999891006289 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 999891006290 Putative motility protein; Region: YjfB_motility; pfam14070 999891006291 MgtC family; Region: MgtC; pfam02308 999891006292 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891006293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891006294 putative DNA binding site [nucleotide binding]; other site 999891006295 putative Zn2+ binding site [ion binding]; other site 999891006296 hypothetical protein; Provisional; Region: PRK09272 999891006297 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 999891006298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891006299 motif II; other site 999891006300 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 999891006301 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 999891006302 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 999891006303 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 999891006304 beta-galactosidase; Region: BGL; TIGR03356 999891006305 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 999891006306 methionine cluster; other site 999891006307 active site 999891006308 phosphorylation site [posttranslational modification] 999891006309 metal binding site [ion binding]; metal-binding site 999891006310 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 999891006311 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 999891006312 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 999891006313 active site 999891006314 P-loop; other site 999891006315 phosphorylation site [posttranslational modification] 999891006316 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 999891006317 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 999891006318 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891006319 putative Zn2+ binding site [ion binding]; other site 999891006320 putative DNA binding site [nucleotide binding]; other site 999891006321 dimerization interface [polypeptide binding]; other site 999891006322 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891006323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891006324 putative substrate translocation pore; other site 999891006325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891006326 Uncharacterized conserved protein [Function unknown]; Region: COG1359 999891006327 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 999891006328 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 999891006329 Kelch motif; Region: Kelch_1; pfam01344 999891006330 Kelch domain; Region: Kelch; smart00612 999891006331 Kelch motif; Region: Kelch_1; pfam01344 999891006332 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 999891006333 Kelch domain; Region: Kelch; smart00612 999891006334 YoqO-like protein; Region: YoqO; pfam14037 999891006335 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 999891006336 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 999891006337 Y-family of DNA polymerases; Region: PolY; cl12025 999891006338 active site 999891006339 YolD-like protein; Region: YolD; pfam08863 999891006340 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891006341 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 999891006342 Coenzyme A binding pocket [chemical binding]; other site 999891006343 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 999891006344 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 999891006345 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 999891006346 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 999891006347 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 999891006348 LXG domain of WXG superfamily; Region: LXG; pfam04740 999891006349 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 999891006350 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 999891006351 Helix-turn-helix domain; Region: HTH_17; pfam12728 999891006352 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 999891006353 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 999891006354 amidase catalytic site [active] 999891006355 Zn binding residues [ion binding]; other site 999891006356 substrate binding site [chemical binding]; other site 999891006357 Bacterial SH3 domain; Region: SH3_3; cl17532 999891006358 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 999891006359 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 999891006360 holin, SPP1 family; Region: holin_SPP1; TIGR01592 999891006361 Haemolysin XhlA; Region: XhlA; pfam10779 999891006362 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 999891006363 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 999891006364 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 999891006365 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 999891006366 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891006367 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 999891006368 N-acetyl-D-glucosamine binding site [chemical binding]; other site 999891006369 catalytic residue [active] 999891006370 cell division protein FtsE; Provisional; Region: PRK10908 999891006371 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 999891006372 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 999891006373 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 999891006374 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 999891006375 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 999891006376 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 999891006377 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 999891006378 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 999891006379 Phage terminase large subunit; Region: Terminase_3; cl12054 999891006380 Terminase-like family; Region: Terminase_6; pfam03237 999891006381 Uncharacterized conserved protein [Function unknown]; Region: COG5484 999891006382 Helix-turn-helix domain; Region: HTH_28; pfam13518 999891006383 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 999891006384 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 999891006385 homoserine O-acetyltransferase; Provisional; Region: PRK08775 999891006386 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 999891006387 cyclase homology domain; Region: CHD; cd07302 999891006388 nucleotidyl binding site; other site 999891006389 metal binding site [ion binding]; metal-binding site 999891006390 dimer interface [polypeptide binding]; other site 999891006391 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 999891006392 Ligand Binding Site [chemical binding]; other site 999891006393 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 999891006394 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 999891006395 cell division protein ZipA; Provisional; Region: PRK01741 999891006396 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 999891006397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891006398 Walker A motif; other site 999891006399 ATP binding site [chemical binding]; other site 999891006400 Walker B motif; other site 999891006401 arginine finger; other site 999891006402 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 999891006403 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 999891006404 Hypothetical protein Yqai; Region: Yqai; pfam09466 999891006405 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 999891006406 Helix-turn-helix domain; Region: HTH_17; pfam12728 999891006407 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999891006408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891006409 non-specific DNA binding site [nucleotide binding]; other site 999891006410 salt bridge; other site 999891006411 sequence-specific DNA binding site [nucleotide binding]; other site 999891006412 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999891006413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891006414 non-specific DNA binding site [nucleotide binding]; other site 999891006415 salt bridge; other site 999891006416 sequence-specific DNA binding site [nucleotide binding]; other site 999891006417 Staphylococcal nuclease homologues; Region: SNc; smart00318 999891006418 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 999891006419 Catalytic site; other site 999891006420 Excalibur calcium-binding domain; Region: Excalibur; smart00894 999891006421 Domain of unknown function (DUF955); Region: DUF955; pfam06114 999891006422 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 999891006423 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 999891006424 Int/Topo IB signature motif; other site 999891006425 cystathionine beta-lyase; Provisional; Region: PRK08064 999891006426 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 999891006427 homodimer interface [polypeptide binding]; other site 999891006428 substrate-cofactor binding pocket; other site 999891006429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891006430 catalytic residue [active] 999891006431 cystathionine gamma-synthase; Reviewed; Region: PRK08247 999891006432 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 999891006433 homodimer interface [polypeptide binding]; other site 999891006434 substrate-cofactor binding pocket; other site 999891006435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891006436 catalytic residue [active] 999891006437 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 999891006438 Putative esterase; Region: Esterase; pfam00756 999891006439 hypothetical protein; Provisional; Region: PRK13679 999891006440 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 999891006441 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 999891006442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891006443 Coenzyme A binding pocket [chemical binding]; other site 999891006444 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 999891006445 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 999891006446 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 999891006447 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 999891006448 Walker A/P-loop; other site 999891006449 ATP binding site [chemical binding]; other site 999891006450 Q-loop/lid; other site 999891006451 ABC transporter signature motif; other site 999891006452 Walker B; other site 999891006453 D-loop; other site 999891006454 H-loop/switch region; other site 999891006455 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 999891006456 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 999891006457 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 999891006458 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 999891006459 Part of AAA domain; Region: AAA_19; pfam13245 999891006460 Family description; Region: UvrD_C_2; pfam13538 999891006461 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 999891006462 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 999891006463 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 999891006464 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 999891006465 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 999891006466 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 999891006467 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 999891006468 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 999891006469 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 999891006470 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 999891006471 NAD binding site [chemical binding]; other site 999891006472 homotetramer interface [polypeptide binding]; other site 999891006473 homodimer interface [polypeptide binding]; other site 999891006474 substrate binding site [chemical binding]; other site 999891006475 active site 999891006476 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 999891006477 dimer interface [polypeptide binding]; other site 999891006478 substrate binding site [chemical binding]; other site 999891006479 ATP binding site [chemical binding]; other site 999891006480 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 999891006481 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 999891006482 ATP binding site [chemical binding]; other site 999891006483 substrate interface [chemical binding]; other site 999891006484 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 999891006485 ThiS interaction site; other site 999891006486 putative active site [active] 999891006487 tetramer interface [polypeptide binding]; other site 999891006488 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 999891006489 thiS-thiF/thiG interaction site; other site 999891006490 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 999891006491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 999891006492 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 999891006493 thiamine phosphate binding site [chemical binding]; other site 999891006494 active site 999891006495 pyrophosphate binding site [ion binding]; other site 999891006496 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 999891006497 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 999891006498 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 999891006499 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 999891006500 TrkA-N domain; Region: TrkA_N; pfam02254 999891006501 TrkA-C domain; Region: TrkA_C; pfam02080 999891006502 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 999891006503 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 999891006504 active site 999891006505 metal binding site [ion binding]; metal-binding site 999891006506 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 999891006507 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 999891006508 active site 999891006509 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 999891006510 ATP-NAD kinase; Region: NAD_kinase; pfam01513 999891006511 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 999891006512 synthetase active site [active] 999891006513 NTP binding site [chemical binding]; other site 999891006514 metal binding site [ion binding]; metal-binding site 999891006515 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 999891006516 putative active site [active] 999891006517 putative metal binding residues [ion binding]; other site 999891006518 signature motif; other site 999891006519 putative triphosphate binding site [ion binding]; other site 999891006520 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 999891006521 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 999891006522 N-acetyl-D-glucosamine binding site [chemical binding]; other site 999891006523 catalytic residue [active] 999891006524 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 999891006525 apolar tunnel; other site 999891006526 heme binding site [chemical binding]; other site 999891006527 dimerization interface [polypeptide binding]; other site 999891006528 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 999891006529 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 999891006530 catalytic residues [active] 999891006531 oligoendopeptidase F; Region: pepF; TIGR00181 999891006532 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 999891006533 active site 999891006534 Zn binding site [ion binding]; other site 999891006535 Competence protein CoiA-like family; Region: CoiA; cl11541 999891006536 adaptor protein; Provisional; Region: PRK02315 999891006537 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 999891006538 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 999891006539 ArsC family; Region: ArsC; pfam03960 999891006540 putative catalytic residues [active] 999891006541 thiol/disulfide switch; other site 999891006542 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 999891006543 Coenzyme A binding pocket [chemical binding]; other site 999891006544 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 999891006545 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 999891006546 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 999891006547 Walker A/P-loop; other site 999891006548 ATP binding site [chemical binding]; other site 999891006549 Q-loop/lid; other site 999891006550 ABC transporter signature motif; other site 999891006551 Walker B; other site 999891006552 D-loop; other site 999891006553 H-loop/switch region; other site 999891006554 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 999891006555 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 999891006556 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 999891006557 Walker A/P-loop; other site 999891006558 ATP binding site [chemical binding]; other site 999891006559 Q-loop/lid; other site 999891006560 ABC transporter signature motif; other site 999891006561 Walker B; other site 999891006562 D-loop; other site 999891006563 H-loop/switch region; other site 999891006564 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 999891006565 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 999891006566 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 999891006567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891006568 dimer interface [polypeptide binding]; other site 999891006569 conserved gate region; other site 999891006570 putative PBP binding loops; other site 999891006571 ABC-ATPase subunit interface; other site 999891006572 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 999891006573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891006574 dimer interface [polypeptide binding]; other site 999891006575 conserved gate region; other site 999891006576 putative PBP binding loops; other site 999891006577 ABC-ATPase subunit interface; other site 999891006578 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 999891006579 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 999891006580 peptide binding site [polypeptide binding]; other site 999891006581 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 999891006582 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 999891006583 active site 999891006584 HIGH motif; other site 999891006585 dimer interface [polypeptide binding]; other site 999891006586 KMSKS motif; other site 999891006587 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 999891006588 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 999891006589 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 999891006590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891006591 dimer interface [polypeptide binding]; other site 999891006592 conserved gate region; other site 999891006593 putative PBP binding loops; other site 999891006594 ABC-ATPase subunit interface; other site 999891006595 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 999891006596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891006597 dimer interface [polypeptide binding]; other site 999891006598 conserved gate region; other site 999891006599 putative PBP binding loops; other site 999891006600 ABC-ATPase subunit interface; other site 999891006601 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 999891006602 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 999891006603 peptide binding site [polypeptide binding]; other site 999891006604 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 999891006605 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 999891006606 Walker A/P-loop; other site 999891006607 ATP binding site [chemical binding]; other site 999891006608 Q-loop/lid; other site 999891006609 ABC transporter signature motif; other site 999891006610 Walker B; other site 999891006611 D-loop; other site 999891006612 H-loop/switch region; other site 999891006613 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 999891006614 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 999891006615 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 999891006616 Walker A/P-loop; other site 999891006617 ATP binding site [chemical binding]; other site 999891006618 Q-loop/lid; other site 999891006619 ABC transporter signature motif; other site 999891006620 Walker B; other site 999891006621 D-loop; other site 999891006622 H-loop/switch region; other site 999891006623 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 999891006624 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 999891006625 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 999891006626 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 999891006627 dimer interface [polypeptide binding]; other site 999891006628 active site 999891006629 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 999891006630 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 999891006631 dimer interface [polypeptide binding]; other site 999891006632 active site 999891006633 CoA binding pocket [chemical binding]; other site 999891006634 ComZ; Region: ComZ; pfam10815 999891006635 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 999891006636 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 999891006637 putative ligand binding site [chemical binding]; other site 999891006638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999891006639 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 999891006640 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 999891006641 YjzC-like protein; Region: YjzC; pfam14168 999891006642 ornithine carbamoyltransferase; Provisional; Region: PRK00779 999891006643 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 999891006644 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 999891006645 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 999891006646 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 999891006647 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 999891006648 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 999891006649 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 999891006650 ATP-grasp domain; Region: ATP-grasp_4; cl17255 999891006651 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 999891006652 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 999891006653 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 999891006654 catalytic site [active] 999891006655 subunit interface [polypeptide binding]; other site 999891006656 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 999891006657 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 999891006658 inhibitor-cofactor binding pocket; inhibition site 999891006659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891006660 catalytic residue [active] 999891006661 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 999891006662 nucleotide binding site [chemical binding]; other site 999891006663 N-acetyl-L-glutamate binding site [chemical binding]; other site 999891006664 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 999891006665 heterotetramer interface [polypeptide binding]; other site 999891006666 active site pocket [active] 999891006667 cleavage site 999891006668 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 999891006669 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 999891006670 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891006671 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 999891006672 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 999891006673 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 999891006674 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 999891006675 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 999891006676 active site 999891006677 Int/Topo IB signature motif; other site 999891006678 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 999891006679 ferric uptake regulator; Provisional; Region: fur; PRK09462 999891006680 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 999891006681 metal binding site 2 [ion binding]; metal-binding site 999891006682 putative DNA binding helix; other site 999891006683 metal binding site 1 [ion binding]; metal-binding site 999891006684 dimer interface [polypeptide binding]; other site 999891006685 structural Zn2+ binding site [ion binding]; other site 999891006686 stage II sporulation protein M; Region: spo_II_M; TIGR02831 999891006687 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 999891006688 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 999891006689 Malic enzyme, N-terminal domain; Region: malic; pfam00390 999891006690 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 999891006691 NAD(P) binding pocket [chemical binding]; other site 999891006692 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 999891006693 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 999891006694 Aspartase; Region: Aspartase; cd01357 999891006695 active sites [active] 999891006696 tetramer interface [polypeptide binding]; other site 999891006697 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 999891006698 active site 999891006699 homodimer interface [polypeptide binding]; other site 999891006700 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999891006701 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891006702 non-specific DNA binding site [nucleotide binding]; other site 999891006703 salt bridge; other site 999891006704 sequence-specific DNA binding site [nucleotide binding]; other site 999891006705 TIGR00375 family protein; Region: TIGR00375 999891006706 PHP-associated; Region: PHP_C; pfam13263 999891006707 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 999891006708 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 999891006709 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 999891006710 dimer interface [polypeptide binding]; other site 999891006711 ADP-ribose binding site [chemical binding]; other site 999891006712 active site 999891006713 nudix motif; other site 999891006714 metal binding site [ion binding]; metal-binding site 999891006715 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 999891006716 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999891006717 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999891006718 active site 999891006719 catalytic tetrad [active] 999891006720 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 999891006721 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 999891006722 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 999891006723 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 999891006724 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 999891006725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 999891006726 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 999891006727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891006728 Coenzyme A binding pocket [chemical binding]; other site 999891006729 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 999891006730 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 999891006731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891006732 Coenzyme A binding pocket [chemical binding]; other site 999891006733 DNA polymerase IV; Reviewed; Region: PRK03103 999891006734 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 999891006735 active site 999891006736 DNA binding site [nucleotide binding] 999891006737 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 999891006738 YolD-like protein; Region: YolD; pfam08863 999891006739 YqzH-like protein; Region: YqzH; pfam14164 999891006740 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 999891006741 Domain of unknown function DUF20; Region: UPF0118; pfam01594 999891006742 pantothenate kinase; Provisional; Region: PRK05439 999891006743 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 999891006744 ATP-binding site [chemical binding]; other site 999891006745 CoA-binding site [chemical binding]; other site 999891006746 Mg2+-binding site [ion binding]; other site 999891006747 D-serine dehydratase; Provisional; Region: PRK02991 999891006748 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 999891006749 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 999891006750 catalytic residue [active] 999891006751 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 999891006752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999891006753 NAD(P) binding site [chemical binding]; other site 999891006754 active site 999891006755 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 999891006756 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 999891006757 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 999891006758 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999891006759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999891006760 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 999891006761 dimerization interface [polypeptide binding]; other site 999891006762 GlpM protein; Region: GlpM; cl01212 999891006763 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 999891006764 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 999891006765 active site 999891006766 FMN binding site [chemical binding]; other site 999891006767 substrate binding site [chemical binding]; other site 999891006768 homotetramer interface [polypeptide binding]; other site 999891006769 catalytic residue [active] 999891006770 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 999891006771 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 999891006772 ribonuclease Z; Region: RNase_Z; TIGR02651 999891006773 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 999891006774 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 999891006775 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 999891006776 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 999891006777 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 999891006778 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 999891006779 DNA polymerase IV; Validated; Region: PRK01810 999891006780 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 999891006781 active site 999891006782 DNA binding site [nucleotide binding] 999891006783 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 999891006784 OxaA-like protein precursor; Validated; Region: PRK01622 999891006785 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 999891006786 potential frameshift: common BLAST hit: gi|308174181|ref|YP_003920886.1| deacylase 999891006787 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 999891006788 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 999891006789 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 999891006790 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 999891006791 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 999891006792 dimer interface [polypeptide binding]; other site 999891006793 substrate binding site [chemical binding]; other site 999891006794 metal binding site [ion binding]; metal-binding site 999891006795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 999891006796 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 999891006797 Predicted membrane protein [Function unknown]; Region: COG4129 999891006798 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 999891006799 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 999891006800 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 999891006801 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 999891006802 Walker A/P-loop; other site 999891006803 ATP binding site [chemical binding]; other site 999891006804 Q-loop/lid; other site 999891006805 ABC transporter signature motif; other site 999891006806 Walker B; other site 999891006807 D-loop; other site 999891006808 H-loop/switch region; other site 999891006809 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 999891006810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891006811 dimer interface [polypeptide binding]; other site 999891006812 conserved gate region; other site 999891006813 putative PBP binding loops; other site 999891006814 ABC-ATPase subunit interface; other site 999891006815 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999891006816 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 999891006817 substrate binding pocket [chemical binding]; other site 999891006818 membrane-bound complex binding site; other site 999891006819 hinge residues; other site 999891006820 Disulphide isomerase; Region: Disulph_isomer; pfam06491 999891006821 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 999891006822 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 999891006823 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 999891006824 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 999891006825 E3 interaction surface; other site 999891006826 lipoyl attachment site [posttranslational modification]; other site 999891006827 e3 binding domain; Region: E3_binding; pfam02817 999891006828 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 999891006829 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 999891006830 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 999891006831 alpha subunit interface [polypeptide binding]; other site 999891006832 TPP binding site [chemical binding]; other site 999891006833 heterodimer interface [polypeptide binding]; other site 999891006834 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 999891006835 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 999891006836 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 999891006837 tetramer interface [polypeptide binding]; other site 999891006838 TPP-binding site [chemical binding]; other site 999891006839 heterodimer interface [polypeptide binding]; other site 999891006840 phosphorylation loop region [posttranslational modification] 999891006841 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 999891006842 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 999891006843 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999891006844 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 999891006845 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 999891006846 nucleotide binding site [chemical binding]; other site 999891006847 Acetokinase family; Region: Acetate_kinase; cl17229 999891006848 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 999891006849 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 999891006850 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 999891006851 NAD binding site [chemical binding]; other site 999891006852 Phe binding site; other site 999891006853 phosphate butyryltransferase; Validated; Region: PRK07742 999891006854 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 999891006855 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 999891006856 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 999891006857 putative active site [active] 999891006858 heme pocket [chemical binding]; other site 999891006859 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 999891006860 putative active site [active] 999891006861 heme pocket [chemical binding]; other site 999891006862 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891006863 Walker A motif; other site 999891006864 ATP binding site [chemical binding]; other site 999891006865 Walker B motif; other site 999891006866 arginine finger; other site 999891006867 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 999891006868 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 999891006869 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 999891006870 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 999891006871 tetramer interface [polypeptide binding]; other site 999891006872 active site 999891006873 Mg2+/Mn2+ binding site [ion binding]; other site 999891006874 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 999891006875 2-methylcitrate dehydratase; Region: prpD; TIGR02330 999891006876 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 999891006877 dimer interface [polypeptide binding]; other site 999891006878 Citrate synthase; Region: Citrate_synt; pfam00285 999891006879 active site 999891006880 coenzyme A binding site [chemical binding]; other site 999891006881 citrylCoA binding site [chemical binding]; other site 999891006882 oxalacetate/citrate binding site [chemical binding]; other site 999891006883 catalytic triad [active] 999891006884 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 999891006885 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 999891006886 FAD binding site [chemical binding]; other site 999891006887 homotetramer interface [polypeptide binding]; other site 999891006888 substrate binding pocket [chemical binding]; other site 999891006889 catalytic base [active] 999891006890 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 999891006891 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 999891006892 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 999891006893 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 999891006894 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 999891006895 dimer interface [polypeptide binding]; other site 999891006896 active site 999891006897 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 999891006898 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 999891006899 active site 999891006900 catalytic site [active] 999891006901 metal binding site [ion binding]; metal-binding site 999891006902 dimer interface [polypeptide binding]; other site 999891006903 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 999891006904 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 999891006905 active site 999891006906 metal binding site [ion binding]; metal-binding site 999891006907 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 999891006908 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891006909 sequence-specific DNA binding site [nucleotide binding]; other site 999891006910 salt bridge; other site 999891006911 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 999891006912 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 999891006913 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 999891006914 putative active site [active] 999891006915 putative FMN binding site [chemical binding]; other site 999891006916 putative substrate binding site [chemical binding]; other site 999891006917 putative catalytic residue [active] 999891006918 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 999891006919 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 999891006920 alanine racemase; Region: alr; TIGR00492 999891006921 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 999891006922 active site 999891006923 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 999891006924 dimer interface [polypeptide binding]; other site 999891006925 substrate binding site [chemical binding]; other site 999891006926 catalytic residues [active] 999891006927 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 999891006928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891006929 active site 999891006930 phosphorylation site [posttranslational modification] 999891006931 intermolecular recognition site; other site 999891006932 dimerization interface [polypeptide binding]; other site 999891006933 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 999891006934 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 999891006935 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 999891006936 protein binding site [polypeptide binding]; other site 999891006937 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 999891006938 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 999891006939 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 999891006940 Walker A/P-loop; other site 999891006941 ATP binding site [chemical binding]; other site 999891006942 Q-loop/lid; other site 999891006943 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 999891006944 ABC transporter signature motif; other site 999891006945 Walker B; other site 999891006946 D-loop; other site 999891006947 H-loop/switch region; other site 999891006948 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 999891006949 arginine repressor; Provisional; Region: PRK04280 999891006950 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 999891006951 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 999891006952 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999891006953 RNA binding surface [nucleotide binding]; other site 999891006954 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 999891006955 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 999891006956 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 999891006957 TPP-binding site; other site 999891006958 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 999891006959 PYR/PP interface [polypeptide binding]; other site 999891006960 dimer interface [polypeptide binding]; other site 999891006961 TPP binding site [chemical binding]; other site 999891006962 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 999891006963 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 999891006964 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 999891006965 substrate binding pocket [chemical binding]; other site 999891006966 chain length determination region; other site 999891006967 substrate-Mg2+ binding site; other site 999891006968 catalytic residues [active] 999891006969 aspartate-rich region 1; other site 999891006970 active site lid residues [active] 999891006971 aspartate-rich region 2; other site 999891006972 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 999891006973 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 999891006974 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 999891006975 generic binding surface II; other site 999891006976 generic binding surface I; other site 999891006977 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 999891006978 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 999891006979 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 999891006980 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 999891006981 homodimer interface [polypeptide binding]; other site 999891006982 NADP binding site [chemical binding]; other site 999891006983 substrate binding site [chemical binding]; other site 999891006984 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 999891006985 putative RNA binding site [nucleotide binding]; other site 999891006986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 999891006987 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 999891006988 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 999891006989 ATP-grasp domain; Region: ATP-grasp_4; cl17255 999891006990 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 999891006991 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 999891006992 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 999891006993 carboxyltransferase (CT) interaction site; other site 999891006994 biotinylation site [posttranslational modification]; other site 999891006995 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 999891006996 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 999891006997 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 999891006998 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 999891006999 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 999891007000 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 999891007001 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 999891007002 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 999891007003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891007004 Walker A motif; other site 999891007005 ATP binding site [chemical binding]; other site 999891007006 Walker B motif; other site 999891007007 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 999891007008 elongation factor P; Validated; Region: PRK00529 999891007009 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 999891007010 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 999891007011 RNA binding site [nucleotide binding]; other site 999891007012 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 999891007013 RNA binding site [nucleotide binding]; other site 999891007014 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 999891007015 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 999891007016 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 999891007017 active site 999891007018 Conserved membrane protein YqhR; Region: YqhR; pfam11085 999891007019 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 999891007020 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 999891007021 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 999891007022 active site 999891007023 nucleophile elbow; other site 999891007024 manganese transport transcriptional regulator; Provisional; Region: PRK03902 999891007025 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 999891007026 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 999891007027 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 999891007028 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 999891007029 active site residue [active] 999891007030 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 999891007031 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 999891007032 tetramer interface [polypeptide binding]; other site 999891007033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891007034 catalytic residue [active] 999891007035 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 999891007036 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 999891007037 tetramer interface [polypeptide binding]; other site 999891007038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891007039 catalytic residue [active] 999891007040 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 999891007041 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 999891007042 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 999891007043 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 999891007044 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999891007045 ATP binding site [chemical binding]; other site 999891007046 putative Mg++ binding site [ion binding]; other site 999891007047 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999891007048 nucleotide binding region [chemical binding]; other site 999891007049 ATP-binding site [chemical binding]; other site 999891007050 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 999891007051 Anti-repressor SinI; Region: SinI; pfam08671 999891007052 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999891007053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891007054 non-specific DNA binding site [nucleotide binding]; other site 999891007055 salt bridge; other site 999891007056 sequence-specific DNA binding site [nucleotide binding]; other site 999891007057 Anti-repressor SinI; Region: SinI; pfam08671 999891007058 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 999891007059 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 999891007060 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 999891007061 Catalytic site [active] 999891007062 YqxM protein; Region: YqxM_for_SipW; TIGR04087 999891007063 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 999891007064 YqzE-like protein; Region: YqzE; pfam14038 999891007065 ComG operon protein 7; Region: ComGG; pfam14173 999891007066 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 999891007067 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 999891007068 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 999891007069 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 999891007070 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 999891007071 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 999891007072 Type II/IV secretion system protein; Region: T2SE; pfam00437 999891007073 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 999891007074 Walker A motif; other site 999891007075 ATP binding site [chemical binding]; other site 999891007076 Walker B motif; other site 999891007077 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 999891007078 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 999891007079 Cl binding site [ion binding]; other site 999891007080 oligomer interface [polypeptide binding]; other site 999891007081 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 999891007082 Domain of unknown function DUF21; Region: DUF21; pfam01595 999891007083 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 999891007084 Transporter associated domain; Region: CorC_HlyC; smart01091 999891007085 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 999891007086 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 999891007087 ArsC family; Region: ArsC; pfam03960 999891007088 putative catalytic residues [active] 999891007089 thiol/disulfide switch; other site 999891007090 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 999891007091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 999891007092 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 999891007093 Uncharacterized conserved protein [Function unknown]; Region: COG0011 999891007094 potential frameshift: common BLAST hit: gi|308174275|ref|YP_003920980.1| lipoprotein 999891007095 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 999891007096 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 999891007097 putative active site [active] 999891007098 Zn binding site [ion binding]; other site 999891007099 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 999891007100 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 999891007101 nucleotide binding site [chemical binding]; other site 999891007102 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 999891007103 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 999891007104 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 999891007105 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 999891007106 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 999891007107 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 999891007108 YceG-like family; Region: YceG; pfam02618 999891007109 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 999891007110 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 999891007111 Walker A/P-loop; other site 999891007112 ATP binding site [chemical binding]; other site 999891007113 Q-loop/lid; other site 999891007114 ABC transporter signature motif; other site 999891007115 Walker B; other site 999891007116 D-loop; other site 999891007117 H-loop/switch region; other site 999891007118 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 999891007119 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 999891007120 Walker A/P-loop; other site 999891007121 ATP binding site [chemical binding]; other site 999891007122 Q-loop/lid; other site 999891007123 ABC transporter signature motif; other site 999891007124 Walker B; other site 999891007125 D-loop; other site 999891007126 H-loop/switch region; other site 999891007127 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 999891007128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891007129 dimer interface [polypeptide binding]; other site 999891007130 conserved gate region; other site 999891007131 ABC-ATPase subunit interface; other site 999891007132 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 999891007133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891007134 dimer interface [polypeptide binding]; other site 999891007135 conserved gate region; other site 999891007136 putative PBP binding loops; other site 999891007137 ABC-ATPase subunit interface; other site 999891007138 PBP superfamily domain; Region: PBP_like_2; cl17296 999891007139 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 999891007140 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 999891007141 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 999891007142 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 999891007143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891007144 putative substrate translocation pore; other site 999891007145 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891007146 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 999891007147 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 999891007148 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 999891007149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 999891007150 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 999891007151 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 999891007152 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 999891007153 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 999891007154 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 999891007155 Uncharacterized conserved protein [Function unknown]; Region: COG5663 999891007156 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 999891007157 metal binding site 2 [ion binding]; metal-binding site 999891007158 putative DNA binding helix; other site 999891007159 metal binding site 1 [ion binding]; metal-binding site 999891007160 dimer interface [polypeptide binding]; other site 999891007161 structural Zn2+ binding site [ion binding]; other site 999891007162 Uncharacterized conserved protein [Function unknown]; Region: COG1284 999891007163 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999891007164 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999891007165 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 999891007166 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 999891007167 endonuclease IV; Provisional; Region: PRK01060 999891007168 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 999891007169 AP (apurinic/apyrimidinic) site pocket; other site 999891007170 DNA interaction; other site 999891007171 Metal-binding active site; metal-binding site 999891007172 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 999891007173 DEAD-like helicases superfamily; Region: DEXDc; smart00487 999891007174 ATP binding site [chemical binding]; other site 999891007175 Mg++ binding site [ion binding]; other site 999891007176 motif III; other site 999891007177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999891007178 nucleotide binding region [chemical binding]; other site 999891007179 ATP-binding site [chemical binding]; other site 999891007180 YqfQ-like protein; Region: YqfQ; pfam14181 999891007181 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 999891007182 LytB protein; Region: LYTB; pfam02401 999891007183 Uncharacterized conserved protein [Function unknown]; Region: COG0327 999891007184 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 999891007185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 999891007186 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 999891007187 Uncharacterized conserved protein [Function unknown]; Region: COG0327 999891007188 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 999891007189 Family of unknown function (DUF633); Region: DUF633; pfam04816 999891007190 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 999891007191 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 999891007192 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 999891007193 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 999891007194 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 999891007195 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999891007196 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 999891007197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999891007198 DNA binding residues [nucleotide binding] 999891007199 DNA primase; Validated; Region: dnaG; PRK05667 999891007200 CHC2 zinc finger; Region: zf-CHC2; pfam01807 999891007201 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 999891007202 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 999891007203 active site 999891007204 metal binding site [ion binding]; metal-binding site 999891007205 interdomain interaction site; other site 999891007206 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 999891007207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 999891007208 PEP synthetase regulatory protein; Provisional; Region: PRK05339 999891007209 HTH domain; Region: HTH_11; pfam08279 999891007210 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 999891007211 FOG: CBS domain [General function prediction only]; Region: COG0517 999891007212 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 999891007213 DALR anticodon binding domain; Region: DALR_1; pfam05746 999891007214 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 999891007215 dimer interface [polypeptide binding]; other site 999891007216 motif 1; other site 999891007217 active site 999891007218 motif 2; other site 999891007219 motif 3; other site 999891007220 Recombination protein O N terminal; Region: RecO_N; pfam11967 999891007221 DNA repair protein RecO; Region: reco; TIGR00613 999891007222 Recombination protein O C terminal; Region: RecO_C; pfam02565 999891007223 YqzL-like protein; Region: YqzL; pfam14006 999891007224 GTPase Era; Reviewed; Region: era; PRK00089 999891007225 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 999891007226 G1 box; other site 999891007227 GTP/Mg2+ binding site [chemical binding]; other site 999891007228 Switch I region; other site 999891007229 G2 box; other site 999891007230 Switch II region; other site 999891007231 G3 box; other site 999891007232 G4 box; other site 999891007233 G5 box; other site 999891007234 KH domain; Region: KH_2; pfam07650 999891007235 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 999891007236 active site 999891007237 catalytic motif [active] 999891007238 Zn binding site [ion binding]; other site 999891007239 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 999891007240 metal-binding heat shock protein; Provisional; Region: PRK00016 999891007241 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 999891007242 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 999891007243 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 999891007244 Zn2+ binding site [ion binding]; other site 999891007245 Mg2+ binding site [ion binding]; other site 999891007246 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 999891007247 PhoH-like protein; Region: PhoH; pfam02562 999891007248 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 999891007249 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 999891007250 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 999891007251 hypothetical protein; Provisional; Region: PRK13665 999891007252 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 999891007253 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 999891007254 dimer interface [polypeptide binding]; other site 999891007255 active site residues [active] 999891007256 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 999891007257 Yqey-like protein; Region: YqeY; pfam09424 999891007258 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 999891007259 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 999891007260 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 999891007261 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 999891007262 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 999891007263 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 999891007264 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 999891007265 FeS/SAM binding site; other site 999891007266 TRAM domain; Region: TRAM; cl01282 999891007267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 999891007268 RNA methyltransferase, RsmE family; Region: TIGR00046 999891007269 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 999891007270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891007271 S-adenosylmethionine binding site [chemical binding]; other site 999891007272 chaperone protein DnaJ; Provisional; Region: PRK14280 999891007273 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 999891007274 HSP70 interaction site [polypeptide binding]; other site 999891007275 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 999891007276 substrate binding site [polypeptide binding]; other site 999891007277 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 999891007278 Zn binding sites [ion binding]; other site 999891007279 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 999891007280 dimer interface [polypeptide binding]; other site 999891007281 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 999891007282 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 999891007283 nucleotide binding site [chemical binding]; other site 999891007284 NEF interaction site [polypeptide binding]; other site 999891007285 SBD interface [polypeptide binding]; other site 999891007286 GrpE; Region: GrpE; pfam01025 999891007287 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 999891007288 dimer interface [polypeptide binding]; other site 999891007289 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 999891007290 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 999891007291 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 999891007292 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 999891007293 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 999891007294 FeS/SAM binding site; other site 999891007295 HemN C-terminal domain; Region: HemN_C; pfam06969 999891007296 GTP-binding protein LepA; Provisional; Region: PRK05433 999891007297 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 999891007298 G1 box; other site 999891007299 putative GEF interaction site [polypeptide binding]; other site 999891007300 GTP/Mg2+ binding site [chemical binding]; other site 999891007301 Switch I region; other site 999891007302 G2 box; other site 999891007303 G3 box; other site 999891007304 Switch II region; other site 999891007305 G4 box; other site 999891007306 G5 box; other site 999891007307 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 999891007308 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 999891007309 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 999891007310 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 999891007311 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 999891007312 stage II sporulation protein P; Region: spore_II_P; TIGR02867 999891007313 germination protease; Provisional; Region: PRK02858 999891007314 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 999891007315 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 999891007316 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 999891007317 YqzM-like protein; Region: YqzM; pfam14141 999891007318 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 999891007319 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 999891007320 Competence protein; Region: Competence; pfam03772 999891007321 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 999891007322 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 999891007323 catalytic motif [active] 999891007324 Zn binding site [ion binding]; other site 999891007325 SLBB domain; Region: SLBB; pfam10531 999891007326 comEA protein; Region: comE; TIGR01259 999891007327 Helix-hairpin-helix motif; Region: HHH; pfam00633 999891007328 late competence protein ComER; Validated; Region: PRK07680 999891007329 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 999891007330 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 999891007331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891007332 S-adenosylmethionine binding site [chemical binding]; other site 999891007333 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 999891007334 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 999891007335 Zn2+ binding site [ion binding]; other site 999891007336 Mg2+ binding site [ion binding]; other site 999891007337 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 999891007338 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 999891007339 active site 999891007340 (T/H)XGH motif; other site 999891007341 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 999891007342 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 999891007343 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 999891007344 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 999891007345 shikimate binding site; other site 999891007346 NAD(P) binding site [chemical binding]; other site 999891007347 GTPase YqeH; Provisional; Region: PRK13796 999891007348 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 999891007349 GTP/Mg2+ binding site [chemical binding]; other site 999891007350 G4 box; other site 999891007351 G5 box; other site 999891007352 G1 box; other site 999891007353 Switch I region; other site 999891007354 G2 box; other site 999891007355 G3 box; other site 999891007356 Switch II region; other site 999891007357 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 999891007358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891007359 active site 999891007360 motif I; other site 999891007361 motif II; other site 999891007362 Sporulation inhibitor A; Region: Sda; pfam08970 999891007363 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 999891007364 active site 999891007365 catalytic triad [active] 999891007366 oxyanion hole [active] 999891007367 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 999891007368 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 999891007369 NodB motif; other site 999891007370 active site 999891007371 catalytic site [active] 999891007372 metal binding site [ion binding]; metal-binding site 999891007373 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 999891007374 amidase catalytic site [active] 999891007375 Zn binding residues [ion binding]; other site 999891007376 substrate binding site [chemical binding]; other site 999891007377 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 999891007378 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 999891007379 Uncharacterized conserved protein [Function unknown]; Region: COG0398 999891007380 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 999891007381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891007382 Coenzyme A binding pocket [chemical binding]; other site 999891007383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891007384 putative substrate translocation pore; other site 999891007385 sporulation sigma factor SigK; Reviewed; Region: PRK05803 999891007386 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 999891007387 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999891007388 DNA binding residues [nucleotide binding] 999891007389 Domain of unknown function (DUF303); Region: DUF303; pfam03629 999891007390 Transcriptional regulator PadR-like family; Region: PadR; cl17335 999891007391 Predicted transcriptional regulators [Transcription]; Region: COG1695 999891007392 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999891007393 DNA binding residues [nucleotide binding] 999891007394 hypothetical protein; Validated; Region: PRK06217 999891007395 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 999891007396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891007397 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891007398 putative substrate translocation pore; other site 999891007399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891007400 DinB family; Region: DinB; pfam05163 999891007401 DinB superfamily; Region: DinB_2; pfam12867 999891007402 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 999891007403 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 999891007404 active site 999891007405 motif I; other site 999891007406 motif II; other site 999891007407 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891007408 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 999891007409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891007410 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 999891007411 active site 999891007412 motif I; other site 999891007413 motif II; other site 999891007414 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 999891007415 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 999891007416 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 999891007417 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 999891007418 putative active site [active] 999891007419 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 999891007420 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 999891007421 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 999891007422 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 999891007423 active site 999891007424 P-loop; other site 999891007425 phosphorylation site [posttranslational modification] 999891007426 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 999891007427 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999891007428 active site 999891007429 phosphorylation site [posttranslational modification] 999891007430 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 999891007431 HTH domain; Region: HTH_11; cl17392 999891007432 Mga helix-turn-helix domain; Region: Mga; pfam05043 999891007433 PRD domain; Region: PRD; pfam00874 999891007434 PRD domain; Region: PRD; pfam00874 999891007435 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 999891007436 active site 999891007437 P-loop; other site 999891007438 phosphorylation site [posttranslational modification] 999891007439 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999891007440 active site 999891007441 phosphorylation site [posttranslational modification] 999891007442 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 999891007443 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 999891007444 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 999891007445 putative deacylase active site [active] 999891007446 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999891007447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999891007448 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 999891007449 putative dimerization interface [polypeptide binding]; other site 999891007450 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 999891007451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891007452 putative substrate translocation pore; other site 999891007453 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 999891007454 Cytochrome P450; Region: p450; pfam00067 999891007455 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 999891007456 Flavodoxin; Region: Flavodoxin_1; pfam00258 999891007457 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 999891007458 FAD binding pocket [chemical binding]; other site 999891007459 FAD binding motif [chemical binding]; other site 999891007460 catalytic residues [active] 999891007461 NAD binding pocket [chemical binding]; other site 999891007462 phosphate binding motif [ion binding]; other site 999891007463 beta-alpha-beta structure motif; other site 999891007464 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891007465 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891007466 Methyltransferase domain; Region: Methyltransf_11; pfam08241 999891007467 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 999891007468 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 999891007469 Uncharacterized conserved protein [Function unknown]; Region: COG5609 999891007470 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 999891007471 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 999891007472 catalytic loop [active] 999891007473 iron binding site [ion binding]; other site 999891007474 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 999891007475 4Fe-4S binding domain; Region: Fer4; pfam00037 999891007476 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 999891007477 [4Fe-4S] binding site [ion binding]; other site 999891007478 molybdopterin cofactor binding site; other site 999891007479 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 999891007480 molybdopterin cofactor binding site; other site 999891007481 Uncharacterized conserved protein [Function unknown]; Region: COG2427 999891007482 YrhC-like protein; Region: YrhC; pfam14143 999891007483 cystathionine beta-lyase; Provisional; Region: PRK07671 999891007484 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 999891007485 homodimer interface [polypeptide binding]; other site 999891007486 substrate-cofactor binding pocket; other site 999891007487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891007488 catalytic residue [active] 999891007489 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 999891007490 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 999891007491 dimer interface [polypeptide binding]; other site 999891007492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891007493 catalytic residue [active] 999891007494 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 999891007495 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 999891007496 Methyltransferase domain; Region: Methyltransf_31; pfam13847 999891007497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891007498 S-adenosylmethionine binding site [chemical binding]; other site 999891007499 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 999891007500 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 999891007501 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 999891007502 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 999891007503 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 999891007504 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 999891007505 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 999891007506 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 999891007507 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 999891007508 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 999891007509 ATP-binding site [chemical binding]; other site 999891007510 Sugar specificity; other site 999891007511 Pyrimidine base specificity; other site 999891007512 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 999891007513 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 999891007514 Peptidase family U32; Region: Peptidase_U32; pfam01136 999891007515 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 999891007516 Peptidase family U32; Region: Peptidase_U32; pfam01136 999891007517 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 999891007518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891007519 S-adenosylmethionine binding site [chemical binding]; other site 999891007520 conserved hypothetical protein, YceG family; Region: TIGR00247 999891007521 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 999891007522 dimerization interface [polypeptide binding]; other site 999891007523 hypothetical protein; Provisional; Region: PRK13678 999891007524 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 999891007525 hypothetical protein; Provisional; Region: PRK05473 999891007526 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 999891007527 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 999891007528 motif 1; other site 999891007529 active site 999891007530 motif 2; other site 999891007531 motif 3; other site 999891007532 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 999891007533 DHHA1 domain; Region: DHHA1; pfam02272 999891007534 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 999891007535 Domain of unknown function DUF20; Region: UPF0118; pfam01594 999891007536 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 999891007537 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 999891007538 Walker A/P-loop; other site 999891007539 ATP binding site [chemical binding]; other site 999891007540 Q-loop/lid; other site 999891007541 ABC transporter signature motif; other site 999891007542 Walker B; other site 999891007543 D-loop; other site 999891007544 H-loop/switch region; other site 999891007545 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 999891007546 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999891007547 substrate binding pocket [chemical binding]; other site 999891007548 membrane-bound complex binding site; other site 999891007549 hinge residues; other site 999891007550 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 999891007551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891007552 dimer interface [polypeptide binding]; other site 999891007553 conserved gate region; other site 999891007554 putative PBP binding loops; other site 999891007555 ABC-ATPase subunit interface; other site 999891007556 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 999891007557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891007558 dimer interface [polypeptide binding]; other site 999891007559 ABC-ATPase subunit interface; other site 999891007560 putative PBP binding loops; other site 999891007561 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 999891007562 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 999891007563 AAA domain; Region: AAA_30; pfam13604 999891007564 Family description; Region: UvrD_C_2; pfam13538 999891007565 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891007566 binding surface 999891007567 TPR repeat; Region: TPR_11; pfam13414 999891007568 TPR motif; other site 999891007569 TPR repeat; Region: TPR_11; pfam13414 999891007570 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891007571 binding surface 999891007572 TPR motif; other site 999891007573 TPR repeat; Region: TPR_11; pfam13414 999891007574 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 999891007575 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 999891007576 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 999891007577 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 999891007578 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 999891007579 catalytic residue [active] 999891007580 Predicted transcriptional regulator [Transcription]; Region: COG1959 999891007581 Transcriptional regulator; Region: Rrf2; pfam02082 999891007582 recombination factor protein RarA; Reviewed; Region: PRK13342 999891007583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891007584 Walker A motif; other site 999891007585 ATP binding site [chemical binding]; other site 999891007586 Walker B motif; other site 999891007587 arginine finger; other site 999891007588 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 999891007589 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 999891007590 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 999891007591 putative ATP binding site [chemical binding]; other site 999891007592 putative substrate interface [chemical binding]; other site 999891007593 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 999891007594 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 999891007595 dimer interface [polypeptide binding]; other site 999891007596 anticodon binding site; other site 999891007597 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 999891007598 homodimer interface [polypeptide binding]; other site 999891007599 motif 1; other site 999891007600 active site 999891007601 motif 2; other site 999891007602 GAD domain; Region: GAD; pfam02938 999891007603 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 999891007604 active site 999891007605 motif 3; other site 999891007606 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 999891007607 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 999891007608 dimer interface [polypeptide binding]; other site 999891007609 motif 1; other site 999891007610 active site 999891007611 motif 2; other site 999891007612 motif 3; other site 999891007613 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 999891007614 anticodon binding site; other site 999891007615 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 999891007616 Bacterial SH3 domain; Region: SH3_3; pfam08239 999891007617 Bacterial SH3 domain; Region: SH3_3; pfam08239 999891007618 Bacterial SH3 domain; Region: SH3_3; pfam08239 999891007619 Bacterial SH3 domain homologues; Region: SH3b; smart00287 999891007620 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 999891007621 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 999891007622 active site 999891007623 metal binding site [ion binding]; metal-binding site 999891007624 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 999891007625 putative active site [active] 999891007626 dimerization interface [polypeptide binding]; other site 999891007627 putative tRNAtyr binding site [nucleotide binding]; other site 999891007628 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 999891007629 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 999891007630 Zn2+ binding site [ion binding]; other site 999891007631 Mg2+ binding site [ion binding]; other site 999891007632 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 999891007633 synthetase active site [active] 999891007634 NTP binding site [chemical binding]; other site 999891007635 metal binding site [ion binding]; metal-binding site 999891007636 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 999891007637 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 999891007638 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999891007639 active site 999891007640 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 999891007641 DHH family; Region: DHH; pfam01368 999891007642 DHHA1 domain; Region: DHHA1; pfam02272 999891007643 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 999891007644 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 999891007645 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 999891007646 TrkA-C domain; Region: TrkA_C; pfam02080 999891007647 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 999891007648 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 999891007649 Protein export membrane protein; Region: SecD_SecF; pfam02355 999891007650 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 999891007651 stage V sporulation protein B; Region: spore_V_B; TIGR02900 999891007652 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 999891007653 Predicted membrane protein [Function unknown]; Region: COG2323 999891007654 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 999891007655 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 999891007656 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 999891007657 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 999891007658 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 999891007659 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 999891007660 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 999891007661 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 999891007662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891007663 Walker A motif; other site 999891007664 ATP binding site [chemical binding]; other site 999891007665 Walker B motif; other site 999891007666 arginine finger; other site 999891007667 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 999891007668 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 999891007669 RuvA N terminal domain; Region: RuvA_N; pfam01330 999891007670 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 999891007671 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 999891007672 BofC C-terminal domain; Region: BofC_C; pfam08955 999891007673 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 999891007674 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 999891007675 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891007676 quinolinate synthetase; Provisional; Region: PRK09375 999891007677 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 999891007678 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 999891007679 dimerization interface [polypeptide binding]; other site 999891007680 active site 999891007681 L-aspartate oxidase; Provisional; Region: PRK08071 999891007682 L-aspartate oxidase; Provisional; Region: PRK06175 999891007683 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 999891007684 cysteine desulfurase; Provisional; Region: PRK02948 999891007685 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 999891007686 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 999891007687 catalytic residue [active] 999891007688 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 999891007689 HTH domain; Region: HTH_11; pfam08279 999891007690 3H domain; Region: 3H; pfam02829 999891007691 prephenate dehydratase; Provisional; Region: PRK11898 999891007692 Prephenate dehydratase; Region: PDT; pfam00800 999891007693 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 999891007694 putative L-Phe binding site [chemical binding]; other site 999891007695 hypothetical protein; Provisional; Region: PRK04435 999891007696 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 999891007697 GTPase CgtA; Reviewed; Region: obgE; PRK12297 999891007698 GTP1/OBG; Region: GTP1_OBG; pfam01018 999891007699 Obg GTPase; Region: Obg; cd01898 999891007700 G1 box; other site 999891007701 GTP/Mg2+ binding site [chemical binding]; other site 999891007702 Switch I region; other site 999891007703 G2 box; other site 999891007704 G3 box; other site 999891007705 Switch II region; other site 999891007706 G4 box; other site 999891007707 G5 box; other site 999891007708 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 999891007709 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 999891007710 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 999891007711 hypothetical protein; Provisional; Region: PRK14553 999891007712 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 999891007713 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 999891007714 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 999891007715 Peptidase family M50; Region: Peptidase_M50; pfam02163 999891007716 active site 999891007717 putative substrate binding region [chemical binding]; other site 999891007718 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 999891007719 Peptidase family M23; Region: Peptidase_M23; pfam01551 999891007720 septum site-determining protein MinD; Region: minD_bact; TIGR01968 999891007721 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 999891007722 Switch I; other site 999891007723 Switch II; other site 999891007724 septum formation inhibitor; Reviewed; Region: minC; PRK00513 999891007725 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 999891007726 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 999891007727 rod shape-determining protein MreC; Region: mreC; TIGR00219 999891007728 rod shape-determining protein MreC; Region: MreC; pfam04085 999891007729 rod shape-determining protein MreB; Provisional; Region: PRK13927 999891007730 MreB and similar proteins; Region: MreB_like; cd10225 999891007731 nucleotide binding site [chemical binding]; other site 999891007732 Mg binding site [ion binding]; other site 999891007733 putative protofilament interaction site [polypeptide binding]; other site 999891007734 RodZ interaction site [polypeptide binding]; other site 999891007735 hypothetical protein; Reviewed; Region: PRK00024 999891007736 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 999891007737 MPN+ (JAMM) motif; other site 999891007738 Zinc-binding site [ion binding]; other site 999891007739 Maf-like protein; Region: Maf; pfam02545 999891007740 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 999891007741 active site 999891007742 dimer interface [polypeptide binding]; other site 999891007743 Sporulation related domain; Region: SPOR; pfam05036 999891007744 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 999891007745 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 999891007746 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 999891007747 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 999891007748 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 999891007749 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 999891007750 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 999891007751 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 999891007752 active site 999891007753 HIGH motif; other site 999891007754 nucleotide binding site [chemical binding]; other site 999891007755 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 999891007756 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 999891007757 active site 999891007758 KMSKS motif; other site 999891007759 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 999891007760 tRNA binding surface [nucleotide binding]; other site 999891007761 anticodon binding site; other site 999891007762 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 999891007763 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 999891007764 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 999891007765 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 999891007766 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891007767 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 999891007768 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 999891007769 inhibitor-cofactor binding pocket; inhibition site 999891007770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891007771 catalytic residue [active] 999891007772 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 999891007773 dimer interface [polypeptide binding]; other site 999891007774 active site 999891007775 Schiff base residues; other site 999891007776 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 999891007777 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 999891007778 active site 999891007779 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 999891007780 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 999891007781 domain interfaces; other site 999891007782 active site 999891007783 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 999891007784 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 999891007785 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 999891007786 tRNA; other site 999891007787 putative tRNA binding site [nucleotide binding]; other site 999891007788 putative NADP binding site [chemical binding]; other site 999891007789 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 999891007790 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 999891007791 G1 box; other site 999891007792 GTP/Mg2+ binding site [chemical binding]; other site 999891007793 Switch I region; other site 999891007794 G2 box; other site 999891007795 G3 box; other site 999891007796 Switch II region; other site 999891007797 G4 box; other site 999891007798 G5 box; other site 999891007799 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 999891007800 Found in ATP-dependent protease La (LON); Region: LON; smart00464 999891007801 Found in ATP-dependent protease La (LON); Region: LON; smart00464 999891007802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891007803 Walker A motif; other site 999891007804 ATP binding site [chemical binding]; other site 999891007805 Walker B motif; other site 999891007806 arginine finger; other site 999891007807 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 999891007808 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 999891007809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891007810 Walker A motif; other site 999891007811 ATP binding site [chemical binding]; other site 999891007812 Walker B motif; other site 999891007813 arginine finger; other site 999891007814 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 999891007815 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 999891007816 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 999891007817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891007818 Walker A motif; other site 999891007819 ATP binding site [chemical binding]; other site 999891007820 Walker B motif; other site 999891007821 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 999891007822 trigger factor; Provisional; Region: tig; PRK01490 999891007823 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 999891007824 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 999891007825 TPR repeat; Region: TPR_11; pfam13414 999891007826 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891007827 binding surface 999891007828 TPR motif; other site 999891007829 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 999891007830 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 999891007831 substrate binding site [chemical binding]; other site 999891007832 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 999891007833 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 999891007834 substrate binding site [chemical binding]; other site 999891007835 ligand binding site [chemical binding]; other site 999891007836 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 999891007837 tartrate dehydrogenase; Region: TTC; TIGR02089 999891007838 2-isopropylmalate synthase; Validated; Region: PRK00915 999891007839 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 999891007840 active site 999891007841 catalytic residues [active] 999891007842 metal binding site [ion binding]; metal-binding site 999891007843 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 999891007844 ketol-acid reductoisomerase; Provisional; Region: PRK05479 999891007845 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 999891007846 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 999891007847 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 999891007848 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 999891007849 putative valine binding site [chemical binding]; other site 999891007850 dimer interface [polypeptide binding]; other site 999891007851 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 999891007852 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 999891007853 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 999891007854 PYR/PP interface [polypeptide binding]; other site 999891007855 dimer interface [polypeptide binding]; other site 999891007856 TPP binding site [chemical binding]; other site 999891007857 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 999891007858 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 999891007859 TPP-binding site [chemical binding]; other site 999891007860 dimer interface [polypeptide binding]; other site 999891007861 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 999891007862 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 999891007863 active site 999891007864 metal binding site [ion binding]; metal-binding site 999891007865 homotetramer interface [polypeptide binding]; other site 999891007866 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 999891007867 active site 999891007868 dimerization interface [polypeptide binding]; other site 999891007869 ribonuclease PH; Reviewed; Region: rph; PRK00173 999891007870 Ribonuclease PH; Region: RNase_PH_bact; cd11362 999891007871 hexamer interface [polypeptide binding]; other site 999891007872 active site 999891007873 Sporulation and spore germination; Region: Germane; pfam10646 999891007874 Spore germination protein [General function prediction only]; Region: COG5401 999891007875 Sporulation and spore germination; Region: Germane; pfam10646 999891007876 glutamate racemase; Provisional; Region: PRK00865 999891007877 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891007878 MarR family; Region: MarR; pfam01047 999891007879 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 999891007880 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 999891007881 DNA binding residues [nucleotide binding] 999891007882 dimerization interface [polypeptide binding]; other site 999891007883 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 999891007884 active site 999891007885 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 999891007886 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 999891007887 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 999891007888 L-aspartate oxidase; Provisional; Region: PRK06175 999891007889 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 999891007890 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 999891007891 putative Iron-sulfur protein interface [polypeptide binding]; other site 999891007892 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 999891007893 proximal heme binding site [chemical binding]; other site 999891007894 distal heme binding site [chemical binding]; other site 999891007895 putative dimer interface [polypeptide binding]; other site 999891007896 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 999891007897 aspartate kinase; Reviewed; Region: PRK06635 999891007898 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 999891007899 putative nucleotide binding site [chemical binding]; other site 999891007900 putative catalytic residues [active] 999891007901 putative Mg ion binding site [ion binding]; other site 999891007902 putative aspartate binding site [chemical binding]; other site 999891007903 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 999891007904 putative allosteric regulatory site; other site 999891007905 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 999891007906 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 999891007907 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 999891007908 GIY-YIG motif/motif A; other site 999891007909 active site 999891007910 catalytic site [active] 999891007911 putative DNA binding site [nucleotide binding]; other site 999891007912 metal binding site [ion binding]; metal-binding site 999891007913 UvrB/uvrC motif; Region: UVR; pfam02151 999891007914 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 999891007915 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 999891007916 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 999891007917 catalytic residues [active] 999891007918 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 999891007919 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 999891007920 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 999891007921 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 999891007922 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 999891007923 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 999891007924 Ligand binding site [chemical binding]; other site 999891007925 Electron transfer flavoprotein domain; Region: ETF; pfam01012 999891007926 enoyl-CoA hydratase; Provisional; Region: PRK07658 999891007927 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 999891007928 substrate binding site [chemical binding]; other site 999891007929 oxyanion hole (OAH) forming residues; other site 999891007930 trimer interface [polypeptide binding]; other site 999891007931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891007932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891007933 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 999891007934 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 999891007935 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 999891007936 acyl-activating enzyme (AAE) consensus motif; other site 999891007937 putative AMP binding site [chemical binding]; other site 999891007938 putative active site [active] 999891007939 putative CoA binding site [chemical binding]; other site 999891007940 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 999891007941 Predicted membrane protein [Function unknown]; Region: COG3766 999891007942 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 999891007943 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 999891007944 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 999891007945 MutS domain III; Region: MutS_III; pfam05192 999891007946 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 999891007947 Walker A/P-loop; other site 999891007948 ATP binding site [chemical binding]; other site 999891007949 Q-loop/lid; other site 999891007950 ABC transporter signature motif; other site 999891007951 Walker B; other site 999891007952 D-loop; other site 999891007953 H-loop/switch region; other site 999891007954 Smr domain; Region: Smr; pfam01713 999891007955 hypothetical protein; Provisional; Region: PRK08609 999891007956 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 999891007957 active site 999891007958 primer binding site [nucleotide binding]; other site 999891007959 NTP binding site [chemical binding]; other site 999891007960 metal binding triad [ion binding]; metal-binding site 999891007961 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 999891007962 active site 999891007963 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 999891007964 Colicin V production protein; Region: Colicin_V; pfam02674 999891007965 cell division protein ZapA; Provisional; Region: PRK14126 999891007966 ribonuclease HIII; Provisional; Region: PRK00996 999891007967 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 999891007968 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 999891007969 RNA/DNA hybrid binding site [nucleotide binding]; other site 999891007970 active site 999891007971 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 999891007972 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 999891007973 putative tRNA-binding site [nucleotide binding]; other site 999891007974 B3/4 domain; Region: B3_4; pfam03483 999891007975 tRNA synthetase B5 domain; Region: B5; smart00874 999891007976 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 999891007977 dimer interface [polypeptide binding]; other site 999891007978 motif 1; other site 999891007979 motif 3; other site 999891007980 motif 2; other site 999891007981 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 999891007982 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 999891007983 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 999891007984 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 999891007985 dimer interface [polypeptide binding]; other site 999891007986 motif 1; other site 999891007987 active site 999891007988 motif 2; other site 999891007989 motif 3; other site 999891007990 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 999891007991 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 999891007992 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 999891007993 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 999891007994 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 999891007995 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 999891007996 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 999891007997 FAD binding domain; Region: FAD_binding_4; pfam01565 999891007998 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 999891007999 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 999891008000 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 999891008001 Cysteine-rich domain; Region: CCG; pfam02754 999891008002 Cysteine-rich domain; Region: CCG; pfam02754 999891008003 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 999891008004 Carbon starvation protein CstA; Region: CstA; pfam02554 999891008005 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 999891008006 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 999891008007 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 999891008008 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 999891008009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891008010 dimer interface [polypeptide binding]; other site 999891008011 conserved gate region; other site 999891008012 putative PBP binding loops; other site 999891008013 ABC-ATPase subunit interface; other site 999891008014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891008015 dimer interface [polypeptide binding]; other site 999891008016 conserved gate region; other site 999891008017 putative PBP binding loops; other site 999891008018 ABC-ATPase subunit interface; other site 999891008019 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 999891008020 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 999891008021 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 999891008022 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 999891008023 active site 999891008024 metal binding site [ion binding]; metal-binding site 999891008025 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 999891008026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891008027 active site 999891008028 motif I; other site 999891008029 motif II; other site 999891008030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891008031 motif II; other site 999891008032 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 999891008033 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 999891008034 intersubunit interface [polypeptide binding]; other site 999891008035 active site 999891008036 Zn2+ binding site [ion binding]; other site 999891008037 ribulokinase; Provisional; Region: PRK04123 999891008038 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 999891008039 N- and C-terminal domain interface [polypeptide binding]; other site 999891008040 active site 999891008041 MgATP binding site [chemical binding]; other site 999891008042 catalytic site [active] 999891008043 metal binding site [ion binding]; metal-binding site 999891008044 carbohydrate binding site [chemical binding]; other site 999891008045 homodimer interface [polypeptide binding]; other site 999891008046 L-arabinose isomerase; Provisional; Region: PRK02929 999891008047 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 999891008048 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 999891008049 trimer interface [polypeptide binding]; other site 999891008050 putative substrate binding site [chemical binding]; other site 999891008051 putative metal binding site [ion binding]; other site 999891008052 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 999891008053 substrate binding site [chemical binding]; other site 999891008054 active site 999891008055 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 999891008056 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 999891008057 oligomer interface [polypeptide binding]; other site 999891008058 active site 999891008059 metal binding site [ion binding]; metal-binding site 999891008060 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 999891008061 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 999891008062 23S rRNA binding site [nucleotide binding]; other site 999891008063 L21 binding site [polypeptide binding]; other site 999891008064 L13 binding site [polypeptide binding]; other site 999891008065 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 999891008066 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 999891008067 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 999891008068 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 999891008069 antiholin-like protein LrgB; Provisional; Region: PRK04288 999891008070 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 999891008071 two-component response regulator; Provisional; Region: PRK14084 999891008072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891008073 active site 999891008074 phosphorylation site [posttranslational modification] 999891008075 intermolecular recognition site; other site 999891008076 dimerization interface [polypeptide binding]; other site 999891008077 LytTr DNA-binding domain; Region: LytTR; smart00850 999891008078 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 999891008079 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 999891008080 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 999891008081 Histidine kinase; Region: His_kinase; pfam06580 999891008082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891008083 ATP binding site [chemical binding]; other site 999891008084 Mg2+ binding site [ion binding]; other site 999891008085 G-X-G motif; other site 999891008086 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 999891008087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891008088 motif II; other site 999891008089 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 999891008090 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 999891008091 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 999891008092 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 999891008093 active site 999891008094 dimer interface [polypeptide binding]; other site 999891008095 motif 1; other site 999891008096 motif 2; other site 999891008097 motif 3; other site 999891008098 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 999891008099 anticodon binding site; other site 999891008100 YtxC-like family; Region: YtxC; pfam08812 999891008101 Uncharacterized conserved protein [Function unknown]; Region: COG0398 999891008102 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 999891008103 primosomal protein DnaI; Reviewed; Region: PRK08939 999891008104 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 999891008105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891008106 Walker A motif; other site 999891008107 ATP binding site [chemical binding]; other site 999891008108 Walker B motif; other site 999891008109 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 999891008110 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 999891008111 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 999891008112 ATP cone domain; Region: ATP-cone; pfam03477 999891008113 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 999891008114 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 999891008115 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 999891008116 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 999891008117 Predicted transcriptional regulators [Transcription]; Region: COG1733 999891008118 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 999891008119 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 999891008120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891008121 putative substrate translocation pore; other site 999891008122 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999891008123 active site 999891008124 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999891008125 catalytic tetrad [active] 999891008126 dephospho-CoA kinase; Region: TIGR00152 999891008127 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 999891008128 CoA-binding site [chemical binding]; other site 999891008129 ATP-binding [chemical binding]; other site 999891008130 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 999891008131 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 999891008132 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 999891008133 DNA binding site [nucleotide binding] 999891008134 catalytic residue [active] 999891008135 H2TH interface [polypeptide binding]; other site 999891008136 putative catalytic residues [active] 999891008137 turnover-facilitating residue; other site 999891008138 intercalation triad [nucleotide binding]; other site 999891008139 8OG recognition residue [nucleotide binding]; other site 999891008140 putative reading head residues; other site 999891008141 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 999891008142 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 999891008143 DNA polymerase I; Provisional; Region: PRK05755 999891008144 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 999891008145 active site 999891008146 metal binding site 1 [ion binding]; metal-binding site 999891008147 putative 5' ssDNA interaction site; other site 999891008148 metal binding site 3; metal-binding site 999891008149 metal binding site 2 [ion binding]; metal-binding site 999891008150 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 999891008151 putative DNA binding site [nucleotide binding]; other site 999891008152 putative metal binding site [ion binding]; other site 999891008153 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 999891008154 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 999891008155 active site 999891008156 DNA binding site [nucleotide binding] 999891008157 catalytic site [active] 999891008158 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 999891008159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 999891008160 putative active site [active] 999891008161 heme pocket [chemical binding]; other site 999891008162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891008163 dimer interface [polypeptide binding]; other site 999891008164 phosphorylation site [posttranslational modification] 999891008165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891008166 ATP binding site [chemical binding]; other site 999891008167 Mg2+ binding site [ion binding]; other site 999891008168 G-X-G motif; other site 999891008169 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999891008170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891008171 active site 999891008172 phosphorylation site [posttranslational modification] 999891008173 intermolecular recognition site; other site 999891008174 dimerization interface [polypeptide binding]; other site 999891008175 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999891008176 DNA binding site [nucleotide binding] 999891008177 malate dehydrogenase; Reviewed; Region: PRK06223 999891008178 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 999891008179 NAD(P) binding site [chemical binding]; other site 999891008180 dimer interface [polypeptide binding]; other site 999891008181 tetramer (dimer of dimers) interface [polypeptide binding]; other site 999891008182 substrate binding site [chemical binding]; other site 999891008183 isocitrate dehydrogenase; Reviewed; Region: PRK07006 999891008184 isocitrate dehydrogenase; Validated; Region: PRK07362 999891008185 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 999891008186 dimer interface [polypeptide binding]; other site 999891008187 Citrate synthase; Region: Citrate_synt; pfam00285 999891008188 active site 999891008189 citrylCoA binding site [chemical binding]; other site 999891008190 oxalacetate/citrate binding site [chemical binding]; other site 999891008191 coenzyme A binding site [chemical binding]; other site 999891008192 catalytic triad [active] 999891008193 Protein of unknown function (DUF441); Region: DUF441; pfam04284 999891008194 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 999891008195 Domain of unknown function DUF20; Region: UPF0118; pfam01594 999891008196 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 999891008197 pyruvate kinase; Provisional; Region: PRK06354 999891008198 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 999891008199 domain interfaces; other site 999891008200 active site 999891008201 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 999891008202 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 999891008203 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 999891008204 active site 999891008205 ADP/pyrophosphate binding site [chemical binding]; other site 999891008206 dimerization interface [polypeptide binding]; other site 999891008207 allosteric effector site; other site 999891008208 fructose-1,6-bisphosphate binding site; other site 999891008209 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 999891008210 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 999891008211 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 999891008212 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 999891008213 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 999891008214 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 999891008215 Malic enzyme, N-terminal domain; Region: malic; pfam00390 999891008216 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 999891008217 putative NAD(P) binding site [chemical binding]; other site 999891008218 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 999891008219 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 999891008220 active site 999891008221 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 999891008222 generic binding surface I; other site 999891008223 generic binding surface II; other site 999891008224 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 999891008225 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 999891008226 DHH family; Region: DHH; pfam01368 999891008227 DHHA1 domain; Region: DHHA1; pfam02272 999891008228 YtpI-like protein; Region: YtpI; pfam14007 999891008229 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 999891008230 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891008231 DNA-binding site [nucleotide binding]; DNA binding site 999891008232 DRTGG domain; Region: DRTGG; pfam07085 999891008233 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 999891008234 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 999891008235 active site 2 [active] 999891008236 active site 1 [active] 999891008237 metal-dependent hydrolase; Provisional; Region: PRK00685 999891008238 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 999891008239 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 999891008240 classical (c) SDRs; Region: SDR_c; cd05233 999891008241 NAD(P) binding site [chemical binding]; other site 999891008242 active site 999891008243 argininosuccinate lyase; Provisional; Region: PRK00855 999891008244 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 999891008245 active sites [active] 999891008246 tetramer interface [polypeptide binding]; other site 999891008247 argininosuccinate synthase; Provisional; Region: PRK13820 999891008248 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 999891008249 ANP binding site [chemical binding]; other site 999891008250 Substrate Binding Site II [chemical binding]; other site 999891008251 Substrate Binding Site I [chemical binding]; other site 999891008252 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 999891008253 MPT binding site; other site 999891008254 trimer interface [polypeptide binding]; other site 999891008255 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 999891008256 propionate/acetate kinase; Provisional; Region: PRK12379 999891008257 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 999891008258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891008259 S-adenosylmethionine binding site [chemical binding]; other site 999891008260 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 999891008261 dimer interface [polypeptide binding]; other site 999891008262 catalytic triad [active] 999891008263 peroxidatic and resolving cysteines [active] 999891008264 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 999891008265 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 999891008266 RDD family; Region: RDD; pfam06271 999891008267 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 999891008268 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 999891008269 tandem repeat interface [polypeptide binding]; other site 999891008270 oligomer interface [polypeptide binding]; other site 999891008271 active site residues [active] 999891008272 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 999891008273 ATP-NAD kinase; Region: NAD_kinase; pfam01513 999891008274 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 999891008275 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 999891008276 active site 999891008277 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 999891008278 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 999891008279 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 999891008280 active site 999891008281 acyl-activating enzyme (AAE) consensus motif; other site 999891008282 putative CoA binding site [chemical binding]; other site 999891008283 AMP binding site [chemical binding]; other site 999891008284 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 999891008285 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 999891008286 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 999891008287 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 999891008288 Ligand Binding Site [chemical binding]; other site 999891008289 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 999891008290 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 999891008291 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 999891008292 catalytic residue [active] 999891008293 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 999891008294 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 999891008295 TMPIT-like protein; Region: TMPIT; pfam07851 999891008296 histidinol-phosphatase; Reviewed; Region: PRK08123 999891008297 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 999891008298 active site 999891008299 dimer interface [polypeptide binding]; other site 999891008300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891008301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891008302 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 999891008303 GAF domain; Region: GAF_2; pfam13185 999891008304 GAF domain; Region: GAF_3; pfam13492 999891008305 GAF domain; Region: GAF_2; pfam13185 999891008306 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 999891008307 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 999891008308 metal binding site [ion binding]; metal-binding site 999891008309 active site 999891008310 I-site; other site 999891008311 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 999891008312 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 999891008313 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999891008314 RNA binding surface [nucleotide binding]; other site 999891008315 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 999891008316 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 999891008317 heme-binding site [chemical binding]; other site 999891008318 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 999891008319 FAD binding pocket [chemical binding]; other site 999891008320 FAD binding motif [chemical binding]; other site 999891008321 phosphate binding motif [ion binding]; other site 999891008322 beta-alpha-beta structure motif; other site 999891008323 NAD binding pocket [chemical binding]; other site 999891008324 Heme binding pocket [chemical binding]; other site 999891008325 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 999891008326 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 999891008327 active site 999891008328 catalytic triad [active] 999891008329 oxyanion hole [active] 999891008330 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 999891008331 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 999891008332 Predicted transcriptional regulators [Transcription]; Region: COG1378 999891008333 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 999891008334 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 999891008335 C-terminal domain interface [polypeptide binding]; other site 999891008336 sugar binding site [chemical binding]; other site 999891008337 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 999891008338 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 999891008339 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 999891008340 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 999891008341 active site 999891008342 HIGH motif; other site 999891008343 dimer interface [polypeptide binding]; other site 999891008344 KMSKS motif; other site 999891008345 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999891008346 RNA binding surface [nucleotide binding]; other site 999891008347 acetyl-CoA synthetase; Provisional; Region: PRK04319 999891008348 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 999891008349 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 999891008350 active site 999891008351 acyl-activating enzyme (AAE) consensus motif; other site 999891008352 putative CoA binding site [chemical binding]; other site 999891008353 AMP binding site [chemical binding]; other site 999891008354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891008355 Coenzyme A binding pocket [chemical binding]; other site 999891008356 FOG: CBS domain [General function prediction only]; Region: COG0517 999891008357 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 999891008358 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 999891008359 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 999891008360 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 999891008361 active site 999891008362 Zn binding site [ion binding]; other site 999891008363 flagellar motor protein MotS; Reviewed; Region: PRK06925 999891008364 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 999891008365 ligand binding site [chemical binding]; other site 999891008366 flagellar motor protein MotP; Reviewed; Region: PRK06926 999891008367 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 999891008368 catabolite control protein A; Region: ccpA; TIGR01481 999891008369 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999891008370 DNA binding site [nucleotide binding] 999891008371 domain linker motif; other site 999891008372 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 999891008373 dimerization interface [polypeptide binding]; other site 999891008374 effector binding site; other site 999891008375 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 999891008376 Chorismate mutase type II; Region: CM_2; cl00693 999891008377 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 999891008378 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 999891008379 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 999891008380 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 999891008381 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 999891008382 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 999891008383 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 999891008384 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 999891008385 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 999891008386 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 999891008387 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 999891008388 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 999891008389 putative tRNA-binding site [nucleotide binding]; other site 999891008390 hypothetical protein; Provisional; Region: PRK13668 999891008391 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 999891008392 catalytic residues [active] 999891008393 YtoQ family protein; Region: YtoQ_fam; TIGR03646 999891008394 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 999891008395 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 999891008396 oligomer interface [polypeptide binding]; other site 999891008397 active site 999891008398 metal binding site [ion binding]; metal-binding site 999891008399 Predicted small secreted protein [Function unknown]; Region: COG5584 999891008400 malate dehydrogenase; Provisional; Region: PRK13529 999891008401 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 999891008402 Malic enzyme, N-terminal domain; Region: malic; pfam00390 999891008403 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 999891008404 NAD(P) binding site [chemical binding]; other site 999891008405 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 999891008406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891008407 S-adenosylmethionine binding site [chemical binding]; other site 999891008408 YtzH-like protein; Region: YtzH; pfam14165 999891008409 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 999891008410 active site 999891008411 ATP binding site [chemical binding]; other site 999891008412 Phosphotransferase enzyme family; Region: APH; pfam01636 999891008413 substrate binding site [chemical binding]; other site 999891008414 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 999891008415 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 999891008416 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 999891008417 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 999891008418 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 999891008419 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 999891008420 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 999891008421 dimer interface [polypeptide binding]; other site 999891008422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891008423 catalytic residue [active] 999891008424 dipeptidase PepV; Reviewed; Region: PRK07318 999891008425 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 999891008426 active site 999891008427 metal binding site [ion binding]; metal-binding site 999891008428 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 999891008429 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 999891008430 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 999891008431 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 999891008432 Walker A/P-loop; other site 999891008433 ATP binding site [chemical binding]; other site 999891008434 Q-loop/lid; other site 999891008435 ABC transporter signature motif; other site 999891008436 Walker B; other site 999891008437 D-loop; other site 999891008438 H-loop/switch region; other site 999891008439 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 999891008440 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 999891008441 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 999891008442 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 999891008443 RNA binding surface [nucleotide binding]; other site 999891008444 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 999891008445 active site 999891008446 uracil binding [chemical binding]; other site 999891008447 stage V sporulation protein B; Region: spore_V_B; TIGR02900 999891008448 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 999891008449 HI0933-like protein; Region: HI0933_like; pfam03486 999891008450 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 999891008451 BCCT family transporter; Region: BCCT; pfam02028 999891008452 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 999891008453 Transcriptional regulators [Transcription]; Region: PurR; COG1609 999891008454 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999891008455 DNA binding site [nucleotide binding] 999891008456 domain linker motif; other site 999891008457 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 999891008458 putative ligand binding site [chemical binding]; other site 999891008459 putative dimerization interface [polypeptide binding]; other site 999891008460 PBP superfamily domain; Region: PBP_like_2; cl17296 999891008461 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 999891008462 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 999891008463 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 999891008464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891008465 dimer interface [polypeptide binding]; other site 999891008466 conserved gate region; other site 999891008467 putative PBP binding loops; other site 999891008468 ABC-ATPase subunit interface; other site 999891008469 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 999891008470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891008471 dimer interface [polypeptide binding]; other site 999891008472 conserved gate region; other site 999891008473 putative PBP binding loops; other site 999891008474 ABC-ATPase subunit interface; other site 999891008475 alpha-galactosidase; Provisional; Region: PRK15076 999891008476 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 999891008477 NAD binding site [chemical binding]; other site 999891008478 sugar binding site [chemical binding]; other site 999891008479 divalent metal binding site [ion binding]; other site 999891008480 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 999891008481 dimer interface [polypeptide binding]; other site 999891008482 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 999891008483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891008484 Coenzyme A binding pocket [chemical binding]; other site 999891008485 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 999891008486 active site residue [active] 999891008487 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 999891008488 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 999891008489 HIGH motif; other site 999891008490 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 999891008491 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 999891008492 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 999891008493 active site 999891008494 KMSKS motif; other site 999891008495 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 999891008496 tRNA binding surface [nucleotide binding]; other site 999891008497 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 999891008498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 999891008499 PAS domain; Region: PAS_9; pfam13426 999891008500 putative active site [active] 999891008501 heme pocket [chemical binding]; other site 999891008502 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 999891008503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891008504 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891008505 putative substrate translocation pore; other site 999891008506 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 999891008507 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 999891008508 FtsX-like permease family; Region: FtsX; pfam02687 999891008509 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999891008510 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 999891008511 Walker A/P-loop; other site 999891008512 ATP binding site [chemical binding]; other site 999891008513 Q-loop/lid; other site 999891008514 ABC transporter signature motif; other site 999891008515 Walker B; other site 999891008516 D-loop; other site 999891008517 H-loop/switch region; other site 999891008518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999891008519 dimer interface [polypeptide binding]; other site 999891008520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 999891008521 phosphorylation site [posttranslational modification] 999891008522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891008523 ATP binding site [chemical binding]; other site 999891008524 Mg2+ binding site [ion binding]; other site 999891008525 G-X-G motif; other site 999891008526 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999891008527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891008528 active site 999891008529 phosphorylation site [posttranslational modification] 999891008530 intermolecular recognition site; other site 999891008531 dimerization interface [polypeptide binding]; other site 999891008532 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999891008533 DNA binding site [nucleotide binding] 999891008534 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 999891008535 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 999891008536 FtsX-like permease family; Region: FtsX; pfam02687 999891008537 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999891008538 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 999891008539 Walker A/P-loop; other site 999891008540 ATP binding site [chemical binding]; other site 999891008541 Q-loop/lid; other site 999891008542 ABC transporter signature motif; other site 999891008543 Walker B; other site 999891008544 D-loop; other site 999891008545 H-loop/switch region; other site 999891008546 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 999891008547 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 999891008548 potential frameshift: common BLAST hit: gi|308174719|ref|YP_003921424.1| ABC transporter (ATP-binding protein) 999891008549 Predicted transcriptional regulators [Transcription]; Region: COG1725 999891008550 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891008551 DNA-binding site [nucleotide binding]; DNA binding site 999891008552 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 999891008553 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 999891008554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891008555 S-adenosylmethionine binding site [chemical binding]; other site 999891008556 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 999891008557 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 999891008558 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 999891008559 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 999891008560 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 999891008561 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 999891008562 trimer interface [polypeptide binding]; other site 999891008563 putative metal binding site [ion binding]; other site 999891008564 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 999891008565 Spore germination protein; Region: Spore_permease; cl17796 999891008566 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 999891008567 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 999891008568 active site 999891008569 dimer interface [polypeptide binding]; other site 999891008570 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 999891008571 Ligand Binding Site [chemical binding]; other site 999891008572 Molecular Tunnel; other site 999891008573 S-adenosylmethionine synthetase; Validated; Region: PRK05250 999891008574 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 999891008575 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 999891008576 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 999891008577 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 999891008578 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 999891008579 active site 999891008580 substrate-binding site [chemical binding]; other site 999891008581 metal-binding site [ion binding] 999891008582 ATP binding site [chemical binding]; other site 999891008583 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 999891008584 Dienelactone hydrolase family; Region: DLH; pfam01738 999891008585 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 999891008586 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 999891008587 NMT1-like family; Region: NMT1_2; pfam13379 999891008588 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 999891008589 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 999891008590 Walker A/P-loop; other site 999891008591 ATP binding site [chemical binding]; other site 999891008592 Q-loop/lid; other site 999891008593 ABC transporter signature motif; other site 999891008594 Walker B; other site 999891008595 D-loop; other site 999891008596 H-loop/switch region; other site 999891008597 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 999891008598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891008599 dimer interface [polypeptide binding]; other site 999891008600 conserved gate region; other site 999891008601 putative PBP binding loops; other site 999891008602 ABC-ATPase subunit interface; other site 999891008603 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 999891008604 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 999891008605 nudix motif; other site 999891008606 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 999891008607 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 999891008608 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 999891008609 dimerization interface [polypeptide binding]; other site 999891008610 DPS ferroxidase diiron center [ion binding]; other site 999891008611 ion pore; other site 999891008612 YtkA-like; Region: YtkA; pfam13115 999891008613 S-ribosylhomocysteinase; Provisional; Region: PRK02260 999891008614 Haemolytic domain; Region: Haemolytic; pfam01809 999891008615 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 999891008616 active site clefts [active] 999891008617 zinc binding site [ion binding]; other site 999891008618 dimer interface [polypeptide binding]; other site 999891008619 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 999891008620 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 999891008621 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 999891008622 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 999891008623 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 999891008624 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 999891008625 active site 999891008626 octamer interface [polypeptide binding]; other site 999891008627 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 999891008628 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 999891008629 acyl-activating enzyme (AAE) consensus motif; other site 999891008630 putative AMP binding site [chemical binding]; other site 999891008631 putative active site [active] 999891008632 putative CoA binding site [chemical binding]; other site 999891008633 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 999891008634 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 999891008635 substrate binding site [chemical binding]; other site 999891008636 oxyanion hole (OAH) forming residues; other site 999891008637 trimer interface [polypeptide binding]; other site 999891008638 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 999891008639 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 999891008640 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 999891008641 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 999891008642 dimer interface [polypeptide binding]; other site 999891008643 tetramer interface [polypeptide binding]; other site 999891008644 PYR/PP interface [polypeptide binding]; other site 999891008645 TPP binding site [chemical binding]; other site 999891008646 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 999891008647 TPP-binding site; other site 999891008648 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 999891008649 chorismate binding enzyme; Region: Chorismate_bind; cl10555 999891008650 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 999891008651 TspO/MBR family; Region: TspO_MBR; pfam03073 999891008652 Predicted membrane protein [Function unknown]; Region: COG3859 999891008653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 999891008654 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 999891008655 DinB superfamily; Region: DinB_2; pfam12867 999891008656 DinB family; Region: DinB; cl17821 999891008657 MOSC domain; Region: MOSC; pfam03473 999891008658 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 999891008659 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 999891008660 active site 999891008661 NAD binding site [chemical binding]; other site 999891008662 metal binding site [ion binding]; metal-binding site 999891008663 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 999891008664 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 999891008665 tetramerization interface [polypeptide binding]; other site 999891008666 NAD(P) binding site [chemical binding]; other site 999891008667 catalytic residues [active] 999891008668 Predicted transcriptional regulators [Transcription]; Region: COG1510 999891008669 MarR family; Region: MarR_2; pfam12802 999891008670 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 999891008671 TrkA-N domain; Region: TrkA_N; pfam02254 999891008672 TrkA-C domain; Region: TrkA_C; pfam02080 999891008673 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 999891008674 SH3-like domain; Region: SH3_8; pfam13457 999891008675 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 999891008676 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 999891008677 heme-binding site [chemical binding]; other site 999891008678 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 999891008679 FAD binding pocket [chemical binding]; other site 999891008680 FAD binding motif [chemical binding]; other site 999891008681 phosphate binding motif [ion binding]; other site 999891008682 beta-alpha-beta structure motif; other site 999891008683 NAD binding pocket [chemical binding]; other site 999891008684 Heme binding pocket [chemical binding]; other site 999891008685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 999891008686 binding surface 999891008687 TPR motif; other site 999891008688 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891008689 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891008690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891008691 binding surface 999891008692 TPR motif; other site 999891008693 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 999891008694 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 999891008695 Helix-turn-helix domain; Region: HTH_17; pfam12728 999891008696 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 999891008697 Holin family; Region: Phage_holin_4; cl01989 999891008698 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 999891008699 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 999891008700 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 999891008701 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 999891008702 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 999891008703 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 999891008704 Phage tail protein; Region: Sipho_tail; pfam05709 999891008705 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 999891008706 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 999891008707 Phage-related protein [Function unknown]; Region: COG5412 999891008708 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 999891008709 N-acetyl-D-glucosamine binding site [chemical binding]; other site 999891008710 catalytic residue [active] 999891008711 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 999891008712 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 999891008713 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 999891008714 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 999891008715 oligomerization interface [polypeptide binding]; other site 999891008716 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 999891008717 Phage capsid family; Region: Phage_capsid; pfam05065 999891008718 Phage head maturation protease [General function prediction only]; Region: COG3740 999891008719 Phage portal protein; Region: Phage_portal; pfam04860 999891008720 Phage-related protein [Function unknown]; Region: COG4695; cl01923 999891008721 Phage Terminase; Region: Terminase_1; pfam03354 999891008722 Phage terminase, small subunit; Region: Terminase_4; pfam05119 999891008723 Prophage antirepressor [Transcription]; Region: COG3617 999891008724 BRO family, N-terminal domain; Region: Bro-N; smart01040 999891008725 Helix-turn-helix domain; Region: HTH_17; pfam12728 999891008726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891008727 non-specific DNA binding site [nucleotide binding]; other site 999891008728 salt bridge; other site 999891008729 sequence-specific DNA binding site [nucleotide binding]; other site 999891008730 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 999891008731 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 999891008732 Int/Topo IB signature motif; other site 999891008733 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 999891008734 Domain of unknown function DUF20; Region: UPF0118; pfam01594 999891008735 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 999891008736 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 999891008737 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 999891008738 intracellular protease, PfpI family; Region: PfpI; TIGR01382 999891008739 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 999891008740 proposed catalytic triad [active] 999891008741 conserved cys residue [active] 999891008742 Tar ligand binding domain homologue; Region: TarH; pfam02203 999891008743 Cache domain; Region: Cache_1; pfam02743 999891008744 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 999891008745 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 999891008746 dimerization interface [polypeptide binding]; other site 999891008747 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 999891008748 dimer interface [polypeptide binding]; other site 999891008749 putative CheW interface [polypeptide binding]; other site 999891008750 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 999891008751 Cache domain; Region: Cache_1; pfam02743 999891008752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 999891008753 dimerization interface [polypeptide binding]; other site 999891008754 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 999891008755 dimer interface [polypeptide binding]; other site 999891008756 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 999891008757 putative CheW interface [polypeptide binding]; other site 999891008758 Tar ligand binding domain homologue; Region: TarH; pfam02203 999891008759 Cache domain; Region: Cache_1; pfam02743 999891008760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 999891008761 dimerization interface [polypeptide binding]; other site 999891008762 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 999891008763 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 999891008764 dimer interface [polypeptide binding]; other site 999891008765 putative CheW interface [polypeptide binding]; other site 999891008766 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 999891008767 Cache domain; Region: Cache_1; pfam02743 999891008768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 999891008769 dimerization interface [polypeptide binding]; other site 999891008770 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 999891008771 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 999891008772 dimer interface [polypeptide binding]; other site 999891008773 putative CheW interface [polypeptide binding]; other site 999891008774 transglutaminase; Provisional; Region: tgl; PRK03187 999891008775 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 999891008776 Nitronate monooxygenase; Region: NMO; pfam03060 999891008777 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 999891008778 FMN binding site [chemical binding]; other site 999891008779 substrate binding site [chemical binding]; other site 999891008780 putative catalytic residue [active] 999891008781 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 999891008782 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 999891008783 Ca binding site [ion binding]; other site 999891008784 active site 999891008785 catalytic site [active] 999891008786 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 999891008787 Domain of unknown function DUF21; Region: DUF21; pfam01595 999891008788 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 999891008789 Transporter associated domain; Region: CorC_HlyC; smart01091 999891008790 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 999891008791 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 999891008792 Ion channel; Region: Ion_trans_2; pfam07885 999891008793 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 999891008794 TrkA-N domain; Region: TrkA_N; pfam02254 999891008795 YugN-like family; Region: YugN; pfam08868 999891008796 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 999891008797 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 999891008798 active site 999891008799 dimer interface [polypeptide binding]; other site 999891008800 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 999891008801 dimer interface [polypeptide binding]; other site 999891008802 active site 999891008803 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 999891008804 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 999891008805 dimer interface [polypeptide binding]; other site 999891008806 active site 999891008807 metal binding site [ion binding]; metal-binding site 999891008808 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 999891008809 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 999891008810 dimer interface [polypeptide binding]; other site 999891008811 active site 999891008812 metal binding site [ion binding]; metal-binding site 999891008813 Uncharacterized conserved protein [Function unknown]; Region: COG2155 999891008814 general stress protein 13; Validated; Region: PRK08059 999891008815 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 999891008816 RNA binding site [nucleotide binding]; other site 999891008817 hypothetical protein; Validated; Region: PRK07682 999891008818 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891008819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891008820 homodimer interface [polypeptide binding]; other site 999891008821 catalytic residue [active] 999891008822 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 999891008823 AsnC family; Region: AsnC_trans_reg; pfam01037 999891008824 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 999891008825 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 999891008826 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 999891008827 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891008828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891008829 homodimer interface [polypeptide binding]; other site 999891008830 catalytic residue [active] 999891008831 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999891008832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891008833 dimer interface [polypeptide binding]; other site 999891008834 phosphorylation site [posttranslational modification] 999891008835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891008836 ATP binding site [chemical binding]; other site 999891008837 Mg2+ binding site [ion binding]; other site 999891008838 G-X-G motif; other site 999891008839 Kinase associated protein B; Region: KapB; pfam08810 999891008840 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 999891008841 active site 999891008842 catalytic site [active] 999891008843 substrate binding site [chemical binding]; other site 999891008844 sugar efflux transporter; Region: 2A0120; TIGR00899 999891008845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891008846 putative substrate translocation pore; other site 999891008847 Transglycosylase; Region: Transgly; pfam00912 999891008848 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 999891008849 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 999891008850 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 999891008851 sensory histidine kinase DcuS; Provisional; Region: PRK11086 999891008852 PAS domain; Region: PAS; smart00091 999891008853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891008854 ATP binding site [chemical binding]; other site 999891008855 Mg2+ binding site [ion binding]; other site 999891008856 G-X-G motif; other site 999891008857 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 999891008858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891008859 active site 999891008860 phosphorylation site [posttranslational modification] 999891008861 intermolecular recognition site; other site 999891008862 dimerization interface [polypeptide binding]; other site 999891008863 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 999891008864 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 999891008865 ligand binding site [chemical binding]; other site 999891008866 potential frameshift: common BLAST hit: gi|308174846|ref|YP_003921551.1| carbohydrate ABC transporter (ATP-binding protein); yufO 999891008867 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 999891008868 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 999891008869 TM-ABC transporter signature motif; other site 999891008870 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 999891008871 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 999891008872 TM-ABC transporter signature motif; other site 999891008873 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 999891008874 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 999891008875 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 999891008876 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 999891008877 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 999891008878 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 999891008879 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 999891008880 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 999891008881 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 999891008882 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 999891008883 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 999891008884 CoenzymeA binding site [chemical binding]; other site 999891008885 subunit interaction site [polypeptide binding]; other site 999891008886 PHB binding site; other site 999891008887 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 999891008888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891008889 active site 999891008890 phosphorylation site [posttranslational modification] 999891008891 intermolecular recognition site; other site 999891008892 dimerization interface [polypeptide binding]; other site 999891008893 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 999891008894 DNA binding residues [nucleotide binding] 999891008895 dimerization interface [polypeptide binding]; other site 999891008896 potential frameshift: common BLAST hit: gi|308174859|ref|YP_003921564.1| two-component sensor histidine kinase; comP 999891008897 Bacillus competence pheromone ComX; Region: ComX; pfam05952 999891008898 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 999891008899 aspartate-rich region 2; other site 999891008900 DegQ (SacQ) family; Region: DegQ; pfam08181 999891008901 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 999891008902 EAL domain; Region: EAL; pfam00563 999891008903 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 999891008904 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 999891008905 active site 999891008906 Isochorismatase family; Region: Isochorismatase; pfam00857 999891008907 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 999891008908 catalytic triad [active] 999891008909 conserved cis-peptide bond; other site 999891008910 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 999891008911 YueH-like protein; Region: YueH; pfam14166 999891008912 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 999891008913 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 999891008914 Domain of unknown function DUF20; Region: UPF0118; pfam01594 999891008915 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 999891008916 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 999891008917 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 999891008918 Zn2+ binding site [ion binding]; other site 999891008919 Mg2+ binding site [ion binding]; other site 999891008920 short chain dehydrogenase; Provisional; Region: PRK06924 999891008921 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 999891008922 NADP binding site [chemical binding]; other site 999891008923 homodimer interface [polypeptide binding]; other site 999891008924 active site 999891008925 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 999891008926 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 999891008927 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 999891008928 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 999891008929 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 999891008930 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 999891008931 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 999891008932 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 999891008933 Domain of unknown function DUF87; Region: DUF87; pfam01935 999891008934 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 999891008935 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 999891008936 Uncharacterized small protein [Function unknown]; Region: COG5417 999891008937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 999891008938 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 999891008939 CodY GAF-like domain; Region: CodY; pfam06018 999891008940 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 999891008941 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 999891008942 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 999891008943 hexamer interface [polypeptide binding]; other site 999891008944 ligand binding site [chemical binding]; other site 999891008945 putative active site [active] 999891008946 NAD(P) binding site [chemical binding]; other site 999891008947 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 999891008948 MbtH-like protein; Region: MbtH; cl01279 999891008949 Condensation domain; Region: Condensation; pfam00668 999891008950 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891008951 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 999891008952 acyl-activating enzyme (AAE) consensus motif; other site 999891008953 AMP binding site [chemical binding]; other site 999891008954 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891008955 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 999891008956 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 999891008957 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 999891008958 acyl-activating enzyme (AAE) consensus motif; other site 999891008959 AMP binding site [chemical binding]; other site 999891008960 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 999891008961 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 999891008962 hydrophobic substrate binding pocket; other site 999891008963 Isochorismatase family; Region: Isochorismatase; pfam00857 999891008964 active site 999891008965 conserved cis-peptide bond; other site 999891008966 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 999891008967 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 999891008968 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 999891008969 acyl-activating enzyme (AAE) consensus motif; other site 999891008970 active site 999891008971 AMP binding site [chemical binding]; other site 999891008972 substrate binding site [chemical binding]; other site 999891008973 isochorismate synthase DhbC; Validated; Region: PRK06923 999891008974 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 999891008975 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 999891008976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999891008977 NAD(P) binding site [chemical binding]; other site 999891008978 active site 999891008979 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 999891008980 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 999891008981 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 999891008982 Moco binding site; other site 999891008983 metal coordination site [ion binding]; other site 999891008984 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 999891008985 Predicted permease [General function prediction only]; Region: COG2056 999891008986 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 999891008987 multifunctional aminopeptidase A; Provisional; Region: PRK00913 999891008988 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 999891008989 interface (dimer of trimers) [polypeptide binding]; other site 999891008990 Substrate-binding/catalytic site; other site 999891008991 Zn-binding sites [ion binding]; other site 999891008992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 999891008993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 999891008994 Putative membrane protein; Region: YuiB; pfam14068 999891008995 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 999891008996 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999891008997 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 999891008998 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 999891008999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999891009000 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 999891009001 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 999891009002 active site 999891009003 Integral membrane protein DUF95; Region: DUF95; pfam01944 999891009004 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 999891009005 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 999891009006 Walker A/P-loop; other site 999891009007 ATP binding site [chemical binding]; other site 999891009008 Q-loop/lid; other site 999891009009 ABC transporter signature motif; other site 999891009010 Walker B; other site 999891009011 D-loop; other site 999891009012 H-loop/switch region; other site 999891009013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 999891009014 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 999891009015 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 999891009016 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 999891009017 putative NAD(P) binding site [chemical binding]; other site 999891009018 active site 999891009019 Phage holin; Region: Phage_holin_5; pfam06946 999891009020 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 999891009021 amidase catalytic site [active] 999891009022 Zn binding residues [ion binding]; other site 999891009023 substrate binding site [chemical binding]; other site 999891009024 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 999891009025 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 999891009026 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 999891009027 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 999891009028 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 999891009029 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 999891009030 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 999891009031 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 999891009032 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 999891009033 Phage tail protein; Region: Sipho_tail; pfam05709 999891009034 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 999891009035 Phosphoinositide-specific phospholipase C, efhand-like; Region: efhand_like; pfam09279 999891009036 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 999891009037 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 999891009038 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 999891009039 Helix-turn-helix of insertion element transposase; Region: HTH_Tnp_1_2; pfam13022 999891009040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 999891009041 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 999891009042 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 999891009043 Int/Topo IB signature motif; other site 999891009044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891009045 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999891009046 non-specific DNA binding site [nucleotide binding]; other site 999891009047 salt bridge; other site 999891009048 sequence-specific DNA binding site [nucleotide binding]; other site 999891009049 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999891009050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891009051 non-specific DNA binding site [nucleotide binding]; other site 999891009052 salt bridge; other site 999891009053 sequence-specific DNA binding site [nucleotide binding]; other site 999891009054 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 999891009055 Helix-turn-helix domain; Region: HTH_36; pfam13730 999891009056 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 999891009057 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 999891009058 active site 999891009059 DNA binding site [nucleotide binding] 999891009060 Int/Topo IB signature motif; other site 999891009061 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 999891009062 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 999891009063 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 999891009064 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 999891009065 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 999891009066 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 999891009067 Nucleoside recognition; Region: Gate; pfam07670 999891009068 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 999891009069 hypothetical protein; Provisional; Region: PRK13669 999891009070 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 999891009071 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999891009072 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 999891009073 NifU-like domain; Region: NifU; pfam01106 999891009074 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 999891009075 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 999891009076 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 999891009077 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 999891009078 homoserine kinase; Region: thrB; TIGR00191 999891009079 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 999891009080 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 999891009081 threonine synthase; Reviewed; Region: PRK06721 999891009082 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 999891009083 homodimer interface [polypeptide binding]; other site 999891009084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891009085 catalytic residue [active] 999891009086 homoserine dehydrogenase; Provisional; Region: PRK06349 999891009087 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 999891009088 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 999891009089 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 999891009090 spore coat protein YutH; Region: spore_yutH; TIGR02905 999891009091 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 999891009092 tetramer interfaces [polypeptide binding]; other site 999891009093 binuclear metal-binding site [ion binding]; other site 999891009094 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 999891009095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891009096 active site 999891009097 motif I; other site 999891009098 motif II; other site 999891009099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891009100 Uncharacterized conserved protein [Function unknown]; Region: COG2445 999891009101 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 999891009102 lipoyl synthase; Provisional; Region: PRK05481 999891009103 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 999891009104 FeS/SAM binding site; other site 999891009105 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 999891009106 Peptidase family M23; Region: Peptidase_M23; pfam01551 999891009107 sporulation protein YunB; Region: spo_yunB; TIGR02832 999891009108 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 999891009109 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 999891009110 active site 999891009111 metal binding site [ion binding]; metal-binding site 999891009112 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 999891009113 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 999891009114 Uncharacterized conserved protein [Function unknown]; Region: COG1801 999891009115 allantoinase; Provisional; Region: PRK06189 999891009116 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 999891009117 active site 999891009118 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 999891009119 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 999891009120 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 999891009121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891009122 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891009123 putative substrate translocation pore; other site 999891009124 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 999891009125 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 999891009126 catalytic residue [active] 999891009127 allantoate amidohydrolase; Reviewed; Region: PRK09290 999891009128 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 999891009129 active site 999891009130 metal binding site [ion binding]; metal-binding site 999891009131 dimer interface [polypeptide binding]; other site 999891009132 Endonuclease I; Region: Endonuclease_1; pfam04231 999891009133 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 999891009134 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 999891009135 Walker A/P-loop; other site 999891009136 ATP binding site [chemical binding]; other site 999891009137 Q-loop/lid; other site 999891009138 ABC transporter signature motif; other site 999891009139 Walker B; other site 999891009140 D-loop; other site 999891009141 H-loop/switch region; other site 999891009142 TOBE domain; Region: TOBE_2; pfam08402 999891009143 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 999891009144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891009145 DNA-binding site [nucleotide binding]; DNA binding site 999891009146 UTRA domain; Region: UTRA; pfam07702 999891009147 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 999891009148 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 999891009149 substrate binding site [chemical binding]; other site 999891009150 ATP binding site [chemical binding]; other site 999891009151 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 999891009152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891009153 dimer interface [polypeptide binding]; other site 999891009154 conserved gate region; other site 999891009155 putative PBP binding loops; other site 999891009156 ABC-ATPase subunit interface; other site 999891009157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891009158 dimer interface [polypeptide binding]; other site 999891009159 conserved gate region; other site 999891009160 putative PBP binding loops; other site 999891009161 ABC-ATPase subunit interface; other site 999891009162 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 999891009163 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 999891009164 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 999891009165 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 999891009166 putative active site [active] 999891009167 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 999891009168 dimer interface [polypeptide binding]; other site 999891009169 active site 999891009170 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 999891009171 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 999891009172 DNA binding residues [nucleotide binding] 999891009173 dimer interface [polypeptide binding]; other site 999891009174 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 999891009175 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 999891009176 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 999891009177 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 999891009178 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 999891009179 GIY-YIG motif/motif A; other site 999891009180 active site 999891009181 catalytic site [active] 999891009182 putative DNA binding site [nucleotide binding]; other site 999891009183 metal binding site [ion binding]; metal-binding site 999891009184 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 999891009185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891009186 S-adenosylmethionine binding site [chemical binding]; other site 999891009187 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 999891009188 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 999891009189 chitosan binding site [chemical binding]; other site 999891009190 catalytic residues [active] 999891009191 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 999891009192 FeS assembly protein SufB; Region: sufB; TIGR01980 999891009193 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 999891009194 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 999891009195 trimerization site [polypeptide binding]; other site 999891009196 active site 999891009197 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 999891009198 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 999891009199 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 999891009200 catalytic residue [active] 999891009201 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 999891009202 FeS assembly protein SufD; Region: sufD; TIGR01981 999891009203 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 999891009204 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 999891009205 Walker A/P-loop; other site 999891009206 ATP binding site [chemical binding]; other site 999891009207 Q-loop/lid; other site 999891009208 ABC transporter signature motif; other site 999891009209 Walker B; other site 999891009210 D-loop; other site 999891009211 H-loop/switch region; other site 999891009212 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 999891009213 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 999891009214 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 999891009215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891009216 dimer interface [polypeptide binding]; other site 999891009217 conserved gate region; other site 999891009218 ABC-ATPase subunit interface; other site 999891009219 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 999891009220 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 999891009221 Walker A/P-loop; other site 999891009222 ATP binding site [chemical binding]; other site 999891009223 Q-loop/lid; other site 999891009224 ABC transporter signature motif; other site 999891009225 Walker B; other site 999891009226 D-loop; other site 999891009227 H-loop/switch region; other site 999891009228 NIL domain; Region: NIL; pfam09383 999891009229 SCP-2 sterol transfer family; Region: SCP2; pfam02036 999891009230 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 999891009231 catalytic residues [active] 999891009232 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 999891009233 putative active site [active] 999891009234 putative metal binding site [ion binding]; other site 999891009235 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 999891009236 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 999891009237 lipoyl attachment site [posttranslational modification]; other site 999891009238 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 999891009239 ArsC family; Region: ArsC; pfam03960 999891009240 putative ArsC-like catalytic residues; other site 999891009241 putative TRX-like catalytic residues [active] 999891009242 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 999891009243 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 999891009244 active site 999891009245 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 999891009246 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 999891009247 dimer interface [polypeptide binding]; other site 999891009248 active site 999891009249 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 999891009250 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 999891009251 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 999891009252 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 999891009253 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 999891009254 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 999891009255 substrate binding site [chemical binding]; other site 999891009256 oxyanion hole (OAH) forming residues; other site 999891009257 trimer interface [polypeptide binding]; other site 999891009258 YuzL-like protein; Region: YuzL; pfam14115 999891009259 Proline dehydrogenase; Region: Pro_dh; cl03282 999891009260 Pyruvate formate lyase; Region: PFL; pfam02901 999891009261 Coat F domain; Region: Coat_F; pfam07875 999891009262 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891009263 MarR family; Region: MarR; pfam01047 999891009264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891009265 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891009266 putative substrate translocation pore; other site 999891009267 Restriction endonuclease BamHI; Region: BamHI; pfam02923 999891009268 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999891009269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891009270 non-specific DNA binding site [nucleotide binding]; other site 999891009271 salt bridge; other site 999891009272 sequence-specific DNA binding site [nucleotide binding]; other site 999891009273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891009274 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 999891009275 DNA methylase; Region: N6_N4_Mtase; pfam01555 999891009276 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 999891009277 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 999891009278 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 999891009279 Walker A/P-loop; other site 999891009280 ATP binding site [chemical binding]; other site 999891009281 Q-loop/lid; other site 999891009282 ABC transporter signature motif; other site 999891009283 Walker B; other site 999891009284 D-loop; other site 999891009285 H-loop/switch region; other site 999891009286 YusW-like protein; Region: YusW; pfam14039 999891009287 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 999891009288 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 999891009289 active site 999891009290 Zn binding site [ion binding]; other site 999891009291 short chain dehydrogenase; Provisional; Region: PRK06914 999891009292 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 999891009293 NADP binding site [chemical binding]; other site 999891009294 active site 999891009295 steroid binding site; other site 999891009296 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 999891009297 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 999891009298 dimerization interface [polypeptide binding]; other site 999891009299 DPS ferroxidase diiron center [ion binding]; other site 999891009300 ion pore; other site 999891009301 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 999891009302 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 999891009303 protein binding site [polypeptide binding]; other site 999891009304 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999891009305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891009306 active site 999891009307 phosphorylation site [posttranslational modification] 999891009308 intermolecular recognition site; other site 999891009309 dimerization interface [polypeptide binding]; other site 999891009310 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999891009311 DNA binding site [nucleotide binding] 999891009312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999891009313 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 999891009314 dimerization interface [polypeptide binding]; other site 999891009315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891009316 dimer interface [polypeptide binding]; other site 999891009317 phosphorylation site [posttranslational modification] 999891009318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891009319 ATP binding site [chemical binding]; other site 999891009320 Mg2+ binding site [ion binding]; other site 999891009321 G-X-G motif; other site 999891009322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891009323 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891009324 fumarate hydratase; Reviewed; Region: fumC; PRK00485 999891009325 Class II fumarases; Region: Fumarase_classII; cd01362 999891009326 active site 999891009327 tetramer interface [polypeptide binding]; other site 999891009328 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 999891009329 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 999891009330 Spore germination protein; Region: Spore_permease; pfam03845 999891009331 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 999891009332 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 999891009333 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 999891009334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891009335 active site 999891009336 phosphorylation site [posttranslational modification] 999891009337 intermolecular recognition site; other site 999891009338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 999891009339 DNA binding residues [nucleotide binding] 999891009340 dimerization interface [polypeptide binding]; other site 999891009341 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 999891009342 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 999891009343 dimerization interface [polypeptide binding]; other site 999891009344 Histidine kinase; Region: HisKA_3; pfam07730 999891009345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891009346 ATP binding site [chemical binding]; other site 999891009347 Mg2+ binding site [ion binding]; other site 999891009348 G-X-G motif; other site 999891009349 Predicted membrane protein [Function unknown]; Region: COG4758 999891009350 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 999891009351 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 999891009352 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 999891009353 PspA/IM30 family; Region: PspA_IM30; pfam04012 999891009354 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 999891009355 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 999891009356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891009357 H+ Antiporter protein; Region: 2A0121; TIGR00900 999891009358 putative substrate translocation pore; other site 999891009359 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 999891009360 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 999891009361 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 999891009362 Walker A/P-loop; other site 999891009363 ATP binding site [chemical binding]; other site 999891009364 Q-loop/lid; other site 999891009365 ABC transporter signature motif; other site 999891009366 Walker B; other site 999891009367 D-loop; other site 999891009368 H-loop/switch region; other site 999891009369 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 999891009370 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 999891009371 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 999891009372 ABC-ATPase subunit interface; other site 999891009373 dimer interface [polypeptide binding]; other site 999891009374 putative PBP binding regions; other site 999891009375 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 999891009376 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 999891009377 putative binding site residues; other site 999891009378 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 999891009379 classical (c) SDRs; Region: SDR_c; cd05233 999891009380 NAD(P) binding site [chemical binding]; other site 999891009381 active site 999891009382 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 999891009383 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 999891009384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891009385 dimer interface [polypeptide binding]; other site 999891009386 phosphorylation site [posttranslational modification] 999891009387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891009388 ATP binding site [chemical binding]; other site 999891009389 Mg2+ binding site [ion binding]; other site 999891009390 G-X-G motif; other site 999891009391 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999891009392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891009393 active site 999891009394 phosphorylation site [posttranslational modification] 999891009395 intermolecular recognition site; other site 999891009396 dimerization interface [polypeptide binding]; other site 999891009397 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999891009398 DNA binding site [nucleotide binding] 999891009399 hypothetical protein; Provisional; Region: PRK14082 999891009400 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 999891009401 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 999891009402 DNA binding residues [nucleotide binding] 999891009403 YvrJ protein family; Region: YvrJ; pfam12841 999891009404 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 999891009405 Cupin; Region: Cupin_1; smart00835 999891009406 Cupin; Region: Cupin_1; smart00835 999891009407 Regulatory protein YrvL; Region: YrvL; pfam14184 999891009408 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 999891009409 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 999891009410 Walker A/P-loop; other site 999891009411 ATP binding site [chemical binding]; other site 999891009412 Q-loop/lid; other site 999891009413 ABC transporter signature motif; other site 999891009414 Walker B; other site 999891009415 D-loop; other site 999891009416 H-loop/switch region; other site 999891009417 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 999891009418 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 999891009419 ABC-ATPase subunit interface; other site 999891009420 dimer interface [polypeptide binding]; other site 999891009421 putative PBP binding regions; other site 999891009422 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 999891009423 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 999891009424 ABC-ATPase subunit interface; other site 999891009425 dimer interface [polypeptide binding]; other site 999891009426 putative PBP binding regions; other site 999891009427 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 999891009428 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 999891009429 putative ligand binding residues [chemical binding]; other site 999891009430 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 999891009431 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 999891009432 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 999891009433 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 999891009434 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 999891009435 Sulfatase; Region: Sulfatase; pfam00884 999891009436 DNA binding domain, excisionase family; Region: excise; TIGR01764 999891009437 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 999891009438 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 999891009439 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 999891009440 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 999891009441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891009442 dimer interface [polypeptide binding]; other site 999891009443 conserved gate region; other site 999891009444 putative PBP binding loops; other site 999891009445 ABC-ATPase subunit interface; other site 999891009446 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 999891009447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891009448 active site 999891009449 phosphorylation site [posttranslational modification] 999891009450 intermolecular recognition site; other site 999891009451 dimerization interface [polypeptide binding]; other site 999891009452 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 999891009453 DNA binding residues [nucleotide binding] 999891009454 dimerization interface [polypeptide binding]; other site 999891009455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 999891009456 Histidine kinase; Region: HisKA_3; pfam07730 999891009457 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 999891009458 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 999891009459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891009460 Walker A/P-loop; other site 999891009461 ATP binding site [chemical binding]; other site 999891009462 Q-loop/lid; other site 999891009463 ABC transporter signature motif; other site 999891009464 Walker B; other site 999891009465 D-loop; other site 999891009466 H-loop/switch region; other site 999891009467 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 999891009468 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 999891009469 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 999891009470 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 999891009471 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 999891009472 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999891009473 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999891009474 active site 999891009475 catalytic tetrad [active] 999891009476 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 999891009477 sulfite reductase subunit beta; Provisional; Region: PRK13504 999891009478 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 999891009479 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 999891009480 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 999891009481 Flavodoxin; Region: Flavodoxin_1; pfam00258 999891009482 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 999891009483 FAD binding pocket [chemical binding]; other site 999891009484 FAD binding motif [chemical binding]; other site 999891009485 catalytic residues [active] 999891009486 NAD binding pocket [chemical binding]; other site 999891009487 phosphate binding motif [ion binding]; other site 999891009488 beta-alpha-beta structure motif; other site 999891009489 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 999891009490 Family description; Region: UvrD_C_2; pfam13538 999891009491 Predicted membrane protein [Function unknown]; Region: COG2860 999891009492 UPF0126 domain; Region: UPF0126; pfam03458 999891009493 UPF0126 domain; Region: UPF0126; pfam03458 999891009494 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 999891009495 active site 999891009496 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 999891009497 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 999891009498 Thioredoxin; Region: Thioredoxin_4; pfam13462 999891009499 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 999891009500 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 999891009501 metal-binding site [ion binding] 999891009502 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999891009503 Soluble P-type ATPase [General function prediction only]; Region: COG4087 999891009504 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 999891009505 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 999891009506 metal-binding site [ion binding] 999891009507 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 999891009508 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 999891009509 metal-binding site [ion binding] 999891009510 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 999891009511 Soluble P-type ATPase [General function prediction only]; Region: COG4087 999891009512 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 999891009513 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 999891009514 metal-binding site [ion binding] 999891009515 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 999891009516 putative homodimer interface [polypeptide binding]; other site 999891009517 putative homotetramer interface [polypeptide binding]; other site 999891009518 putative allosteric switch controlling residues; other site 999891009519 putative metal binding site [ion binding]; other site 999891009520 putative homodimer-homodimer interface [polypeptide binding]; other site 999891009521 putative oxidoreductase; Provisional; Region: PRK11579 999891009522 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 999891009523 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 999891009524 azoreductase; Reviewed; Region: PRK00170 999891009525 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 999891009526 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 999891009527 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 999891009528 active site 999891009529 non-prolyl cis peptide bond; other site 999891009530 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 999891009531 catalytic residues [active] 999891009532 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 999891009533 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 999891009534 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 999891009535 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 999891009536 Walker A/P-loop; other site 999891009537 ATP binding site [chemical binding]; other site 999891009538 Q-loop/lid; other site 999891009539 ABC transporter signature motif; other site 999891009540 Walker B; other site 999891009541 D-loop; other site 999891009542 H-loop/switch region; other site 999891009543 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 999891009544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891009545 dimer interface [polypeptide binding]; other site 999891009546 conserved gate region; other site 999891009547 putative PBP binding loops; other site 999891009548 ABC-ATPase subunit interface; other site 999891009549 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 999891009550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891009551 dimer interface [polypeptide binding]; other site 999891009552 conserved gate region; other site 999891009553 putative PBP binding loops; other site 999891009554 ABC-ATPase subunit interface; other site 999891009555 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 999891009556 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999891009557 substrate binding pocket [chemical binding]; other site 999891009558 membrane-bound complex binding site; other site 999891009559 hinge residues; other site 999891009560 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 999891009561 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 999891009562 substrate binding pocket [chemical binding]; other site 999891009563 membrane-bound complex binding site; other site 999891009564 hinge residues; other site 999891009565 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 999891009566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891009567 Coenzyme A binding pocket [chemical binding]; other site 999891009568 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 999891009569 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999891009570 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999891009571 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 999891009572 dimerization interface [polypeptide binding]; other site 999891009573 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 999891009574 classical (c) SDRs; Region: SDR_c; cd05233 999891009575 NAD(P) binding site [chemical binding]; other site 999891009576 active site 999891009577 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 999891009578 RNAase interaction site [polypeptide binding]; other site 999891009579 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 999891009580 SmpB-tmRNA interface; other site 999891009581 putative transporter; Provisional; Region: PRK03699 999891009582 ribonuclease R; Region: RNase_R; TIGR02063 999891009583 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 999891009584 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 999891009585 RNB domain; Region: RNB; pfam00773 999891009586 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 999891009587 RNA binding site [nucleotide binding]; other site 999891009588 Esterase/lipase [General function prediction only]; Region: COG1647 999891009589 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 999891009590 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 999891009591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891009592 salt bridge; other site 999891009593 non-specific DNA binding site [nucleotide binding]; other site 999891009594 sequence-specific DNA binding site [nucleotide binding]; other site 999891009595 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999891009596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891009597 non-specific DNA binding site [nucleotide binding]; other site 999891009598 salt bridge; other site 999891009599 sequence-specific DNA binding site [nucleotide binding]; other site 999891009600 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999891009601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891009602 non-specific DNA binding site [nucleotide binding]; other site 999891009603 salt bridge; other site 999891009604 sequence-specific DNA binding site [nucleotide binding]; other site 999891009605 Predicted transcriptional regulators [Transcription]; Region: COG1733 999891009606 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891009607 dimerization interface [polypeptide binding]; other site 999891009608 putative DNA binding site [nucleotide binding]; other site 999891009609 putative Zn2+ binding site [ion binding]; other site 999891009610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999891009611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891009612 dimer interface [polypeptide binding]; other site 999891009613 phosphorylation site [posttranslational modification] 999891009614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891009615 ATP binding site [chemical binding]; other site 999891009616 Mg2+ binding site [ion binding]; other site 999891009617 G-X-G motif; other site 999891009618 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999891009619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891009620 active site 999891009621 phosphorylation site [posttranslational modification] 999891009622 intermolecular recognition site; other site 999891009623 dimerization interface [polypeptide binding]; other site 999891009624 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999891009625 DNA binding site [nucleotide binding] 999891009626 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 999891009627 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 999891009628 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 999891009629 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 999891009630 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 999891009631 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 999891009632 Walker A/P-loop; other site 999891009633 ATP binding site [chemical binding]; other site 999891009634 Q-loop/lid; other site 999891009635 ABC transporter signature motif; other site 999891009636 Walker B; other site 999891009637 D-loop; other site 999891009638 H-loop/switch region; other site 999891009639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891009640 dimer interface [polypeptide binding]; other site 999891009641 conserved gate region; other site 999891009642 putative PBP binding loops; other site 999891009643 ABC-ATPase subunit interface; other site 999891009644 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 999891009645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891009646 dimer interface [polypeptide binding]; other site 999891009647 conserved gate region; other site 999891009648 putative PBP binding loops; other site 999891009649 ABC-ATPase subunit interface; other site 999891009650 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 999891009651 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 999891009652 Walker A/P-loop; other site 999891009653 ATP binding site [chemical binding]; other site 999891009654 Q-loop/lid; other site 999891009655 ABC transporter signature motif; other site 999891009656 Walker B; other site 999891009657 D-loop; other site 999891009658 H-loop/switch region; other site 999891009659 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 999891009660 Predicted transcriptional regulators [Transcription]; Region: COG1510 999891009661 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891009662 putative DNA binding site [nucleotide binding]; other site 999891009663 putative Zn2+ binding site [ion binding]; other site 999891009664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891009665 dimer interface [polypeptide binding]; other site 999891009666 conserved gate region; other site 999891009667 putative PBP binding loops; other site 999891009668 ABC-ATPase subunit interface; other site 999891009669 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 999891009670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 999891009671 dimer interface [polypeptide binding]; other site 999891009672 conserved gate region; other site 999891009673 putative PBP binding loops; other site 999891009674 ABC-ATPase subunit interface; other site 999891009675 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 999891009676 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 999891009677 Walker A/P-loop; other site 999891009678 ATP binding site [chemical binding]; other site 999891009679 Q-loop/lid; other site 999891009680 ABC transporter signature motif; other site 999891009681 Walker B; other site 999891009682 D-loop; other site 999891009683 H-loop/switch region; other site 999891009684 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 999891009685 Predicted transcriptional regulators [Transcription]; Region: COG1510 999891009686 MarR family; Region: MarR_2; pfam12802 999891009687 membrane protein, MarC family; Region: TIGR00427 999891009688 Predicted membrane protein [Function unknown]; Region: COG4640 999891009689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891009690 Coenzyme A binding pocket [chemical binding]; other site 999891009691 H+ Antiporter protein; Region: 2A0121; TIGR00900 999891009692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891009693 putative substrate translocation pore; other site 999891009694 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 999891009695 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 999891009696 WbqC-like protein family; Region: WbqC; pfam08889 999891009697 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 999891009698 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 999891009699 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 999891009700 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 999891009701 catalytic residue [active] 999891009702 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 999891009703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999891009704 NAD(P) binding site [chemical binding]; other site 999891009705 active site 999891009706 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 999891009707 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 999891009708 inhibitor-cofactor binding pocket; inhibition site 999891009709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891009710 catalytic residue [active] 999891009711 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 999891009712 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 999891009713 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 999891009714 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 999891009715 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 999891009716 putative integrin binding motif; other site 999891009717 PA/protease domain interface [polypeptide binding]; other site 999891009718 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 999891009719 Peptidase family M28; Region: Peptidase_M28; pfam04389 999891009720 metal binding site [ion binding]; metal-binding site 999891009721 enolase; Provisional; Region: eno; PRK00077 999891009722 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 999891009723 dimer interface [polypeptide binding]; other site 999891009724 metal binding site [ion binding]; metal-binding site 999891009725 substrate binding pocket [chemical binding]; other site 999891009726 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 999891009727 phosphoglyceromutase; Provisional; Region: PRK05434 999891009728 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 999891009729 triosephosphate isomerase; Provisional; Region: PRK14565 999891009730 substrate binding site [chemical binding]; other site 999891009731 dimer interface [polypeptide binding]; other site 999891009732 catalytic triad [active] 999891009733 Phosphoglycerate kinase; Region: PGK; pfam00162 999891009734 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 999891009735 substrate binding site [chemical binding]; other site 999891009736 hinge regions; other site 999891009737 ADP binding site [chemical binding]; other site 999891009738 catalytic site [active] 999891009739 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 999891009740 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 999891009741 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 999891009742 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 999891009743 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 999891009744 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 999891009745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891009746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891009747 DNA-binding site [nucleotide binding]; DNA binding site 999891009748 Transcriptional regulators [Transcription]; Region: PurR; COG1609 999891009749 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 999891009750 putative dimerization interface [polypeptide binding]; other site 999891009751 putative ligand binding site [chemical binding]; other site 999891009752 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 999891009753 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 999891009754 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 999891009755 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999891009756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999891009757 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 999891009758 dimerization interface [polypeptide binding]; other site 999891009759 EamA-like transporter family; Region: EamA; pfam00892 999891009760 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 999891009761 EamA-like transporter family; Region: EamA; pfam00892 999891009762 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 999891009763 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 999891009764 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 999891009765 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 999891009766 putative active site [active] 999891009767 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 999891009768 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 999891009769 N- and C-terminal domain interface [polypeptide binding]; other site 999891009770 active site 999891009771 catalytic site [active] 999891009772 metal binding site [ion binding]; metal-binding site 999891009773 carbohydrate binding site [chemical binding]; other site 999891009774 ATP binding site [chemical binding]; other site 999891009775 fructuronate transporter; Provisional; Region: PRK10034; cl15264 999891009776 GntP family permease; Region: GntP_permease; pfam02447 999891009777 Uncharacterized conserved protein [Function unknown]; Region: COG1556 999891009778 iron-sulfur cluster-binding protein; Region: TIGR00273 999891009779 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 999891009780 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 999891009781 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 999891009782 Cysteine-rich domain; Region: CCG; pfam02754 999891009783 Cysteine-rich domain; Region: CCG; pfam02754 999891009784 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 999891009785 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891009786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891009787 homodimer interface [polypeptide binding]; other site 999891009788 catalytic residue [active] 999891009789 Transcriptional regulators [Transcription]; Region: FadR; COG2186 999891009790 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891009791 DNA-binding site [nucleotide binding]; DNA binding site 999891009792 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 999891009793 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 999891009794 L-lactate permease; Region: Lactate_perm; pfam02652 999891009795 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 999891009796 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 999891009797 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 999891009798 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 999891009799 YvfG protein; Region: YvfG; pfam09628 999891009800 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 999891009801 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 999891009802 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 999891009803 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 999891009804 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 999891009805 inhibitor-cofactor binding pocket; inhibition site 999891009806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891009807 catalytic residue [active] 999891009808 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 999891009809 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 999891009810 putative trimer interface [polypeptide binding]; other site 999891009811 putative CoA binding site [chemical binding]; other site 999891009812 Bacterial sugar transferase; Region: Bac_transf; pfam02397 999891009813 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 999891009814 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 999891009815 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 999891009816 active site 999891009817 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 999891009818 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 999891009819 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 999891009820 active site 999891009821 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 999891009822 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 999891009823 putative ADP-binding pocket [chemical binding]; other site 999891009824 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 999891009825 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 999891009826 active site 999891009827 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 999891009828 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 999891009829 putative ADP-binding pocket [chemical binding]; other site 999891009830 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 999891009831 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 999891009832 NAD(P) binding site [chemical binding]; other site 999891009833 homodimer interface [polypeptide binding]; other site 999891009834 substrate binding site [chemical binding]; other site 999891009835 active site 999891009836 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 999891009837 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 999891009838 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 999891009839 Chain length determinant protein; Region: Wzz; cl15801 999891009840 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 999891009841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 999891009842 non-specific DNA binding site [nucleotide binding]; other site 999891009843 salt bridge; other site 999891009844 sequence-specific DNA binding site [nucleotide binding]; other site 999891009845 Anti-repressor SinI; Region: SinI; pfam08671 999891009846 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 999891009847 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 999891009848 substrate binding pocket [chemical binding]; other site 999891009849 catalytic triad [active] 999891009850 RibD C-terminal domain; Region: RibD_C; cl17279 999891009851 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 999891009852 hypothetical protein; Provisional; Region: PRK07236 999891009853 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 999891009854 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 999891009855 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 999891009856 Predicted membrane protein [Function unknown]; Region: COG2364 999891009857 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999891009858 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 999891009859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891009860 Coenzyme A binding pocket [chemical binding]; other site 999891009861 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 999891009862 hypothetical protein; Provisional; Region: PRK00872 999891009863 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 999891009864 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 999891009865 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 999891009866 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 999891009867 nucleophilic elbow; other site 999891009868 catalytic triad; other site 999891009869 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 999891009870 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 999891009871 substrate binding [chemical binding]; other site 999891009872 active site 999891009873 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 999891009874 galactoside permease; Reviewed; Region: lacY; PRK09528 999891009875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891009876 putative substrate translocation pore; other site 999891009877 Transcriptional regulators [Transcription]; Region: PurR; COG1609 999891009878 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999891009879 DNA binding site [nucleotide binding] 999891009880 domain linker motif; other site 999891009881 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 999891009882 dimerization interface [polypeptide binding]; other site 999891009883 ligand binding site [chemical binding]; other site 999891009884 sodium binding site [ion binding]; other site 999891009885 Clp protease; Region: CLP_protease; pfam00574 999891009886 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 999891009887 oligomer interface [polypeptide binding]; other site 999891009888 active site residues [active] 999891009889 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999891009890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999891009891 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 999891009892 dimerization interface [polypeptide binding]; other site 999891009893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 999891009894 benzoate transport; Region: 2A0115; TIGR00895 999891009895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891009896 putative substrate translocation pore; other site 999891009897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891009898 TIGR00730 family protein; Region: TIGR00730 999891009899 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 999891009900 metal binding site [ion binding]; metal-binding site 999891009901 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 999891009902 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 999891009903 Sulfate transporter family; Region: Sulfate_transp; pfam00916 999891009904 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 999891009905 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 999891009906 active site clefts [active] 999891009907 zinc binding site [ion binding]; other site 999891009908 dimer interface [polypeptide binding]; other site 999891009909 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 999891009910 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 999891009911 dimerization interface [polypeptide binding]; other site 999891009912 ligand binding site [chemical binding]; other site 999891009913 NADP binding site [chemical binding]; other site 999891009914 catalytic site [active] 999891009915 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 999891009916 active site 999891009917 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 999891009918 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 999891009919 dimerization domain swap beta strand [polypeptide binding]; other site 999891009920 regulatory protein interface [polypeptide binding]; other site 999891009921 active site 999891009922 regulatory phosphorylation site [posttranslational modification]; other site 999891009923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 999891009924 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 999891009925 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 999891009926 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 999891009927 phosphate binding site [ion binding]; other site 999891009928 putative substrate binding pocket [chemical binding]; other site 999891009929 dimer interface [polypeptide binding]; other site 999891009930 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 999891009931 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 999891009932 putative active site [active] 999891009933 nucleotide binding site [chemical binding]; other site 999891009934 nudix motif; other site 999891009935 putative metal binding site [ion binding]; other site 999891009936 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 999891009937 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 999891009938 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999891009939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 999891009940 GDP/GTP exchange factor Sec2p; Region: Sec2p; pfam06428 999891009941 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 999891009942 NlpC/P60 family; Region: NLPC_P60; pfam00877 999891009943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891009944 binding surface 999891009945 Tetratricopeptide repeat; Region: TPR_16; pfam13432 999891009946 TPR motif; other site 999891009947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891009948 TPR motif; other site 999891009949 binding surface 999891009950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891009951 dimer interface [polypeptide binding]; other site 999891009952 phosphorylation site [posttranslational modification] 999891009953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891009954 ATP binding site [chemical binding]; other site 999891009955 Mg2+ binding site [ion binding]; other site 999891009956 G-X-G motif; other site 999891009957 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999891009958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891009959 active site 999891009960 phosphorylation site [posttranslational modification] 999891009961 intermolecular recognition site; other site 999891009962 dimerization interface [polypeptide binding]; other site 999891009963 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999891009964 DNA binding site [nucleotide binding] 999891009965 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999891009966 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999891009967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891009968 Walker A/P-loop; other site 999891009969 ATP binding site [chemical binding]; other site 999891009970 Q-loop/lid; other site 999891009971 ABC transporter signature motif; other site 999891009972 Walker B; other site 999891009973 D-loop; other site 999891009974 H-loop/switch region; other site 999891009975 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 999891009976 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 999891009977 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 999891009978 metal binding site [ion binding]; metal-binding site 999891009979 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 999891009980 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 999891009981 substrate binding site [chemical binding]; other site 999891009982 glutamase interaction surface [polypeptide binding]; other site 999891009983 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 999891009984 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 999891009985 catalytic residues [active] 999891009986 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 999891009987 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 999891009988 putative active site [active] 999891009989 oxyanion strand; other site 999891009990 catalytic triad [active] 999891009991 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 999891009992 putative active site pocket [active] 999891009993 4-fold oligomerization interface [polypeptide binding]; other site 999891009994 metal binding residues [ion binding]; metal-binding site 999891009995 3-fold/trimer interface [polypeptide binding]; other site 999891009996 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 999891009997 histidinol dehydrogenase; Region: hisD; TIGR00069 999891009998 NAD binding site [chemical binding]; other site 999891009999 dimerization interface [polypeptide binding]; other site 999891010000 product binding site; other site 999891010001 substrate binding site [chemical binding]; other site 999891010002 zinc binding site [ion binding]; other site 999891010003 catalytic residues [active] 999891010004 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 999891010005 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 999891010006 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 999891010007 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 999891010008 dimer interface [polypeptide binding]; other site 999891010009 motif 1; other site 999891010010 active site 999891010011 motif 2; other site 999891010012 motif 3; other site 999891010013 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 999891010014 putative active site [active] 999891010015 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 999891010016 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 999891010017 trimer interface [polypeptide binding]; other site 999891010018 active site 999891010019 substrate binding site [chemical binding]; other site 999891010020 CoA binding site [chemical binding]; other site 999891010021 pyrophosphatase PpaX; Provisional; Region: PRK13288 999891010022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 999891010023 motif I; other site 999891010024 active site 999891010025 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891010026 motif II; other site 999891010027 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 999891010028 HPr kinase/phosphorylase; Provisional; Region: PRK05428 999891010029 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 999891010030 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 999891010031 Hpr binding site; other site 999891010032 active site 999891010033 homohexamer subunit interaction site [polypeptide binding]; other site 999891010034 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 999891010035 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 999891010036 active site 999891010037 dimer interface [polypeptide binding]; other site 999891010038 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 999891010039 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 999891010040 active site 999891010041 trimer interface [polypeptide binding]; other site 999891010042 allosteric site; other site 999891010043 active site lid [active] 999891010044 hexamer (dimer of trimers) interface [polypeptide binding]; other site 999891010045 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 999891010046 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891010047 DNA-binding site [nucleotide binding]; DNA binding site 999891010048 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 999891010049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891010050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891010051 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 999891010052 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 999891010053 putative active site [active] 999891010054 putative metal binding site [ion binding]; other site 999891010055 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 999891010056 Predicted membrane protein [Function unknown]; Region: COG1950 999891010057 PspC domain; Region: PspC; pfam04024 999891010058 Uncharacterized conserved protein [Function unknown]; Region: COG3595 999891010059 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 999891010060 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 999891010061 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 999891010062 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 999891010063 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 999891010064 excinuclease ABC subunit B; Provisional; Region: PRK05298 999891010065 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999891010066 ATP binding site [chemical binding]; other site 999891010067 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999891010068 nucleotide binding region [chemical binding]; other site 999891010069 ATP-binding site [chemical binding]; other site 999891010070 Ultra-violet resistance protein B; Region: UvrB; pfam12344 999891010071 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 999891010072 phosphoenolpyruvate synthase; Validated; Region: PRK06241 999891010073 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 999891010074 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 999891010075 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891010076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891010077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891010078 putative substrate translocation pore; other site 999891010079 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 999891010080 Uncharacterized conserved protein [Function unknown]; Region: COG3391 999891010081 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 999891010082 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 999891010083 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 999891010084 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 999891010085 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 999891010086 C-terminal peptidase (prc); Region: prc; TIGR00225 999891010087 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 999891010088 protein binding site [polypeptide binding]; other site 999891010089 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 999891010090 Catalytic dyad [active] 999891010091 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 999891010092 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 999891010093 Right handed beta helix region; Region: Beta_helix; pfam13229 999891010094 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 999891010095 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 999891010096 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 999891010097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891010098 Walker A/P-loop; other site 999891010099 ATP binding site [chemical binding]; other site 999891010100 Q-loop/lid; other site 999891010101 ABC transporter signature motif; other site 999891010102 Walker B; other site 999891010103 D-loop; other site 999891010104 H-loop/switch region; other site 999891010105 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 999891010106 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 999891010107 Uncharacterized conserved protein [Function unknown]; Region: COG1284 999891010108 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999891010109 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999891010110 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 999891010111 peptide chain release factor 2; Provisional; Region: PRK06746 999891010112 This domain is found in peptide chain release factors; Region: PCRF; smart00937 999891010113 RF-1 domain; Region: RF-1; pfam00472 999891010114 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 999891010115 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 999891010116 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 999891010117 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 999891010118 nucleotide binding region [chemical binding]; other site 999891010119 ATP-binding site [chemical binding]; other site 999891010120 SEC-C motif; Region: SEC-C; pfam02810 999891010121 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 999891010122 30S subunit binding site; other site 999891010123 Flagellar protein FliT; Region: FliT; pfam05400 999891010124 flagellar protein FliS; Validated; Region: fliS; PRK05685 999891010125 flagellar capping protein; Validated; Region: fliD; PRK07737 999891010126 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 999891010127 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 999891010128 flagellin; Provisional; Region: PRK12804 999891010129 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 999891010130 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 999891010131 carbon storage regulator; Provisional; Region: PRK01712 999891010132 flagellar assembly protein FliW; Provisional; Region: PRK13285 999891010133 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 999891010134 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 999891010135 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 999891010136 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 999891010137 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 999891010138 FlgN protein; Region: FlgN; pfam05130 999891010139 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 999891010140 flagellar operon protein TIGR03826; Region: YvyF 999891010141 comF family protein; Region: comF; TIGR00201 999891010142 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999891010143 active site 999891010144 Late competence development protein ComFB; Region: ComFB; pfam10719 999891010145 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 999891010146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999891010147 ATP binding site [chemical binding]; other site 999891010148 putative Mg++ binding site [ion binding]; other site 999891010149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999891010150 nucleotide binding region [chemical binding]; other site 999891010151 ATP-binding site [chemical binding]; other site 999891010152 EDD domain protein, DegV family; Region: DegV; TIGR00762 999891010153 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 999891010154 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 999891010155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891010156 active site 999891010157 phosphorylation site [posttranslational modification] 999891010158 intermolecular recognition site; other site 999891010159 dimerization interface [polypeptide binding]; other site 999891010160 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 999891010161 DNA binding residues [nucleotide binding] 999891010162 dimerization interface [polypeptide binding]; other site 999891010163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 999891010164 Histidine kinase; Region: HisKA_3; pfam07730 999891010165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891010166 ATP binding site [chemical binding]; other site 999891010167 Mg2+ binding site [ion binding]; other site 999891010168 G-X-G motif; other site 999891010169 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 999891010170 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 999891010171 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 999891010172 Transcriptional regulator [Transcription]; Region: LytR; COG1316 999891010173 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 999891010174 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 999891010175 Mg++ binding site [ion binding]; other site 999891010176 putative catalytic motif [active] 999891010177 substrate binding site [chemical binding]; other site 999891010178 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 999891010179 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 999891010180 putative homodimer interface [polypeptide binding]; other site 999891010181 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 999891010182 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 999891010183 active site 999891010184 Chain length determinant protein; Region: Wzz; cl15801 999891010185 O-Antigen ligase; Region: Wzy_C; pfam04932 999891010186 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 999891010187 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 999891010188 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 999891010189 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 999891010190 glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095 999891010191 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 999891010192 colanic acid exporter; Provisional; Region: PRK10459 999891010193 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 999891010194 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 999891010195 Bacterial sugar transferase; Region: Bac_transf; pfam02397 999891010196 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 999891010197 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 999891010198 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 999891010199 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 999891010200 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 999891010201 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 999891010202 active site 999891010203 metal binding site [ion binding]; metal-binding site 999891010204 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 999891010205 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 999891010206 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 999891010207 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 999891010208 Stage II sporulation protein; Region: SpoIID; pfam08486 999891010209 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 999891010210 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 999891010211 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 999891010212 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 999891010213 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 999891010214 active site 999891010215 homodimer interface [polypeptide binding]; other site 999891010216 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 999891010217 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 999891010218 active site 999891010219 tetramer interface; other site 999891010220 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 999891010221 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 999891010222 Walker A/P-loop; other site 999891010223 ATP binding site [chemical binding]; other site 999891010224 Q-loop/lid; other site 999891010225 ABC transporter signature motif; other site 999891010226 Walker B; other site 999891010227 D-loop; other site 999891010228 H-loop/switch region; other site 999891010229 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 999891010230 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 999891010231 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 999891010232 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 999891010233 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 999891010234 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 999891010235 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 999891010236 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 999891010237 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 999891010238 active site 999891010239 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 999891010240 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 999891010241 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 999891010242 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 999891010243 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 999891010244 Bacterial SH3 domain; Region: SH3_3; pfam08239 999891010245 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 999891010246 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 999891010247 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 999891010248 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 999891010249 Spore germination protein; Region: Spore_permease; pfam03845 999891010250 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 999891010251 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 999891010252 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 999891010253 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 999891010254 Probable Catalytic site; other site 999891010255 metal-binding site 999891010256 Methyltransferase domain; Region: Methyltransf_23; pfam13489 999891010257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891010258 S-adenosylmethionine binding site [chemical binding]; other site 999891010259 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 999891010260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891010261 putative substrate translocation pore; other site 999891010262 Transcriptional regulator [Transcription]; Region: LytR; COG1316 999891010263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891010264 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 999891010265 active site 999891010266 motif I; other site 999891010267 motif II; other site 999891010268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891010269 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 999891010270 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 999891010271 NlpC/P60 family; Region: NLPC_P60; pfam00877 999891010272 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 999891010273 NlpC/P60 family; Region: NLPC_P60; pfam00877 999891010274 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 999891010275 NlpC/P60 family; Region: NLPC_P60; pfam00877 999891010276 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 999891010277 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 999891010278 putative active site [active] 999891010279 putative metal binding site [ion binding]; other site 999891010280 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 999891010281 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 999891010282 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 999891010283 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 999891010284 Spore germination protein; Region: Spore_permease; cl17796 999891010285 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 999891010286 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 999891010287 Transcriptional regulators [Transcription]; Region: PurR; COG1609 999891010288 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999891010289 DNA binding site [nucleotide binding] 999891010290 domain linker motif; other site 999891010291 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 999891010292 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 999891010293 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 999891010294 substrate binding site [chemical binding]; other site 999891010295 dimer interface [polypeptide binding]; other site 999891010296 ATP binding site [chemical binding]; other site 999891010297 D-ribose pyranase; Provisional; Region: PRK11797 999891010298 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 999891010299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891010300 Walker A/P-loop; other site 999891010301 ATP binding site [chemical binding]; other site 999891010302 Q-loop/lid; other site 999891010303 ABC transporter signature motif; other site 999891010304 Walker B; other site 999891010305 D-loop; other site 999891010306 H-loop/switch region; other site 999891010307 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 999891010308 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 999891010309 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 999891010310 TM-ABC transporter signature motif; other site 999891010311 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 999891010312 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 999891010313 ligand binding site [chemical binding]; other site 999891010314 dimerization interface [polypeptide binding]; other site 999891010315 Bacterial SH3 domain homologues; Region: SH3b; smart00287 999891010316 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 999891010317 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 999891010318 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 999891010319 acetolactate synthase; Reviewed; Region: PRK08617 999891010320 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 999891010321 PYR/PP interface [polypeptide binding]; other site 999891010322 dimer interface [polypeptide binding]; other site 999891010323 TPP binding site [chemical binding]; other site 999891010324 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 999891010325 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 999891010326 TPP-binding site [chemical binding]; other site 999891010327 dimer interface [polypeptide binding]; other site 999891010328 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 999891010329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999891010330 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 999891010331 putative dimerization interface [polypeptide binding]; other site 999891010332 putative substrate binding pocket [chemical binding]; other site 999891010333 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 999891010334 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 999891010335 transmembrane helices; other site 999891010336 CotH protein; Region: CotH; pfam08757 999891010337 DNA translocase FtsK; Provisional; Region: PRK10263 999891010338 DNA translocase FtsK; Provisional; Region: PRK10263 999891010339 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 999891010340 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 999891010341 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 999891010342 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 999891010343 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891010344 putative DNA binding site [nucleotide binding]; other site 999891010345 putative Zn2+ binding site [ion binding]; other site 999891010346 AsnC family; Region: AsnC_trans_reg; pfam01037 999891010347 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 999891010348 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 999891010349 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 999891010350 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 999891010351 LXG domain of WXG superfamily; Region: LXG; pfam04740 999891010352 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 999891010353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 999891010354 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 999891010355 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 999891010356 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 999891010357 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 999891010358 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 999891010359 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 999891010360 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 999891010361 Nucleotide binding site [chemical binding]; other site 999891010362 DTAP/Switch II; other site 999891010363 Switch I; other site 999891010364 Chain length determinant protein; Region: Wzz; cl15801 999891010365 SWIM zinc finger; Region: SWIM; pfam04434 999891010366 SNF2 Helicase protein; Region: DUF3670; pfam12419 999891010367 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 999891010368 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 999891010369 ATP binding site [chemical binding]; other site 999891010370 putative Mg++ binding site [ion binding]; other site 999891010371 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 999891010372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999891010373 nucleotide binding region [chemical binding]; other site 999891010374 ATP-binding site [chemical binding]; other site 999891010375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891010376 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 999891010377 active site 999891010378 motif I; other site 999891010379 motif II; other site 999891010380 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891010381 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 999891010382 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 999891010383 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 999891010384 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 999891010385 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 999891010386 dimer interface [polypeptide binding]; other site 999891010387 ssDNA binding site [nucleotide binding]; other site 999891010388 tetramer (dimer of dimers) interface [polypeptide binding]; other site 999891010389 YwpF-like protein; Region: YwpF; pfam14183 999891010390 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 999891010391 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 999891010392 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 999891010393 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891010394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891010395 binding surface 999891010396 TPR motif; other site 999891010397 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891010398 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 999891010399 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 999891010400 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 999891010401 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 999891010402 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 999891010403 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 999891010404 rod shape-determining protein Mbl; Provisional; Region: PRK13928 999891010405 MreB and similar proteins; Region: MreB_like; cd10225 999891010406 nucleotide binding site [chemical binding]; other site 999891010407 Mg binding site [ion binding]; other site 999891010408 putative protofilament interaction site [polypeptide binding]; other site 999891010409 RodZ interaction site [polypeptide binding]; other site 999891010410 Stage III sporulation protein D; Region: SpoIIID; pfam12116 999891010411 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891010412 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891010413 putative Zn2+ binding site [ion binding]; other site 999891010414 putative DNA binding site [nucleotide binding]; other site 999891010415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891010416 putative substrate translocation pore; other site 999891010417 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891010418 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 999891010419 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 999891010420 Na binding site [ion binding]; other site 999891010421 putative substrate binding site [chemical binding]; other site 999891010422 potential frameshift: common BLAST hit: gi|308175380|ref|YP_003922085.1| efflux transporter; ywoD 999891010423 Isochorismatase family; Region: Isochorismatase; pfam00857 999891010424 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 999891010425 catalytic triad [active] 999891010426 conserved cis-peptide bond; other site 999891010427 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 999891010428 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 999891010429 Nitrogen regulatory protein P-II; Region: P-II; smart00938 999891010430 cell division protein FtsW; Region: ftsW; TIGR02614 999891010431 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 999891010432 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 999891010433 active site 999891010434 VanZ like family; Region: VanZ; pfam04892 999891010435 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 999891010436 Peptidase family M23; Region: Peptidase_M23; pfam01551 999891010437 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 999891010438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891010439 Coenzyme A binding pocket [chemical binding]; other site 999891010440 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 999891010441 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 999891010442 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 999891010443 putative active site [active] 999891010444 catalytic site [active] 999891010445 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 999891010446 putative active site [active] 999891010447 catalytic site [active] 999891010448 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 999891010449 NADH(P)-binding; Region: NAD_binding_10; pfam13460 999891010450 NAD binding site [chemical binding]; other site 999891010451 substrate binding site [chemical binding]; other site 999891010452 putative active site [active] 999891010453 Predicted transcriptional regulator [Transcription]; Region: COG1959 999891010454 Transcriptional regulator; Region: Rrf2; pfam02082 999891010455 urease subunit alpha; Reviewed; Region: ureC; PRK13207 999891010456 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 999891010457 subunit interactions [polypeptide binding]; other site 999891010458 active site 999891010459 flap region; other site 999891010460 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 999891010461 gamma-beta subunit interface [polypeptide binding]; other site 999891010462 alpha-beta subunit interface [polypeptide binding]; other site 999891010463 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 999891010464 alpha-gamma subunit interface [polypeptide binding]; other site 999891010465 beta-gamma subunit interface [polypeptide binding]; other site 999891010466 CsbD-like; Region: CsbD; pfam05532 999891010467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 999891010468 TPR motif; other site 999891010469 binding surface 999891010470 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891010471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891010472 binding surface 999891010473 TPR motif; other site 999891010474 TPR repeat; Region: TPR_11; pfam13414 999891010475 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 999891010476 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 999891010477 FeS/SAM binding site; other site 999891010478 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 999891010479 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 999891010480 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 999891010481 metal ion-dependent adhesion site (MIDAS); other site 999891010482 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 999891010483 metal ion-dependent adhesion site (MIDAS); other site 999891010484 Stage II sporulation protein; Region: SpoIID; pfam08486 999891010485 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 999891010486 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 999891010487 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 999891010488 hinge; other site 999891010489 active site 999891010490 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 999891010491 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 999891010492 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 999891010493 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 999891010494 gamma subunit interface [polypeptide binding]; other site 999891010495 epsilon subunit interface [polypeptide binding]; other site 999891010496 LBP interface [polypeptide binding]; other site 999891010497 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 999891010498 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 999891010499 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 999891010500 alpha subunit interaction interface [polypeptide binding]; other site 999891010501 Walker A motif; other site 999891010502 ATP binding site [chemical binding]; other site 999891010503 Walker B motif; other site 999891010504 inhibitor binding site; inhibition site 999891010505 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 999891010506 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 999891010507 core domain interface [polypeptide binding]; other site 999891010508 delta subunit interface [polypeptide binding]; other site 999891010509 epsilon subunit interface [polypeptide binding]; other site 999891010510 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 999891010511 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 999891010512 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 999891010513 beta subunit interaction interface [polypeptide binding]; other site 999891010514 Walker A motif; other site 999891010515 ATP binding site [chemical binding]; other site 999891010516 Walker B motif; other site 999891010517 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 999891010518 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 999891010519 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 999891010520 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 999891010521 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 999891010522 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 999891010523 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 999891010524 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 999891010525 ATP synthase I chain; Region: ATP_synt_I; pfam03899 999891010526 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 999891010527 active site 999891010528 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 999891010529 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 999891010530 dimer interface [polypeptide binding]; other site 999891010531 active site 999891010532 glycine-pyridoxal phosphate binding site [chemical binding]; other site 999891010533 folate binding site [chemical binding]; other site 999891010534 hypothetical protein; Provisional; Region: PRK13690 999891010535 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 999891010536 Low molecular weight phosphatase family; Region: LMWPc; cd00115 999891010537 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 999891010538 active site 999891010539 Predicted membrane protein [Function unknown]; Region: COG1971 999891010540 Domain of unknown function DUF; Region: DUF204; pfam02659 999891010541 Domain of unknown function DUF; Region: DUF204; pfam02659 999891010542 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 999891010543 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 999891010544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 999891010545 stage II sporulation protein R; Region: spore_II_R; TIGR02837 999891010546 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 999891010547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891010548 S-adenosylmethionine binding site [chemical binding]; other site 999891010549 peptide chain release factor 1; Validated; Region: prfA; PRK00591 999891010550 This domain is found in peptide chain release factors; Region: PCRF; smart00937 999891010551 RF-1 domain; Region: RF-1; pfam00472 999891010552 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 999891010553 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 999891010554 putative metal binding site [ion binding]; other site 999891010555 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 999891010556 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 999891010557 DNA binding residues [nucleotide binding] 999891010558 Trypanosomal VSG domain; Region: VSG_B; cl11958 999891010559 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 999891010560 malate dehydrogenase; Provisional; Region: PRK13529 999891010561 Malic enzyme, N-terminal domain; Region: malic; pfam00390 999891010562 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 999891010563 NAD(P) binding site [chemical binding]; other site 999891010564 thymidine kinase; Provisional; Region: PRK04296 999891010565 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 999891010566 transcription termination factor Rho; Provisional; Region: rho; PRK09376 999891010567 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 999891010568 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 999891010569 RNA binding site [nucleotide binding]; other site 999891010570 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 999891010571 multimer interface [polypeptide binding]; other site 999891010572 Walker A motif; other site 999891010573 ATP binding site [chemical binding]; other site 999891010574 Walker B motif; other site 999891010575 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 999891010576 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 999891010577 putative active site [active] 999891010578 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 999891010579 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 999891010580 hinge; other site 999891010581 active site 999891010582 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 999891010583 active site 999891010584 intersubunit interactions; other site 999891010585 catalytic residue [active] 999891010586 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 999891010587 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 999891010588 intersubunit interface [polypeptide binding]; other site 999891010589 active site 999891010590 zinc binding site [ion binding]; other site 999891010591 Na+ binding site [ion binding]; other site 999891010592 Response regulator receiver domain; Region: Response_reg; pfam00072 999891010593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891010594 active site 999891010595 phosphorylation site [posttranslational modification] 999891010596 intermolecular recognition site; other site 999891010597 dimerization interface [polypeptide binding]; other site 999891010598 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 999891010599 CTP synthetase; Validated; Region: pyrG; PRK05380 999891010600 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 999891010601 Catalytic site [active] 999891010602 active site 999891010603 UTP binding site [chemical binding]; other site 999891010604 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 999891010605 active site 999891010606 putative oxyanion hole; other site 999891010607 catalytic triad [active] 999891010608 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 999891010609 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 999891010610 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 999891010611 Cysteine-rich domain; Region: CCG; pfam02754 999891010612 Cysteine-rich domain; Region: CCG; pfam02754 999891010613 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 999891010614 PLD-like domain; Region: PLDc_2; pfam13091 999891010615 putative active site [active] 999891010616 catalytic site [active] 999891010617 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 999891010618 PLD-like domain; Region: PLDc_2; pfam13091 999891010619 putative active site [active] 999891010620 catalytic site [active] 999891010621 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 999891010622 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 999891010623 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999891010624 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 999891010625 Walker A/P-loop; other site 999891010626 ATP binding site [chemical binding]; other site 999891010627 Q-loop/lid; other site 999891010628 ABC transporter signature motif; other site 999891010629 Walker B; other site 999891010630 D-loop; other site 999891010631 H-loop/switch region; other site 999891010632 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 999891010633 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 999891010634 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 999891010635 putative active site [active] 999891010636 catalytic site [active] 999891010637 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 999891010638 putative active site [active] 999891010639 catalytic site [active] 999891010640 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 999891010641 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 999891010642 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 999891010643 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 999891010644 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 999891010645 [4Fe-4S] binding site [ion binding]; other site 999891010646 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 999891010647 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 999891010648 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 999891010649 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 999891010650 molybdopterin cofactor binding site; other site 999891010651 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 999891010652 ligand binding site [chemical binding]; other site 999891010653 flexible hinge region; other site 999891010654 YwiC-like protein; Region: YwiC; pfam14256 999891010655 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 999891010656 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 999891010657 ligand binding site [chemical binding]; other site 999891010658 flexible hinge region; other site 999891010659 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 999891010660 putative switch regulator; other site 999891010661 non-specific DNA interactions [nucleotide binding]; other site 999891010662 DNA binding site [nucleotide binding] 999891010663 sequence specific DNA binding site [nucleotide binding]; other site 999891010664 putative cAMP binding site [chemical binding]; other site 999891010665 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 999891010666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891010667 putative substrate translocation pore; other site 999891010668 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 999891010669 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 999891010670 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 999891010671 active site 999891010672 HIGH motif; other site 999891010673 KMSK motif region; other site 999891010674 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 999891010675 tRNA binding surface [nucleotide binding]; other site 999891010676 anticodon binding site; other site 999891010677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 999891010678 Uncharacterized conserved protein [Function unknown]; Region: COG3391 999891010679 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 999891010680 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 999891010681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 999891010682 binding surface 999891010683 TPR motif; other site 999891010684 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891010685 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 999891010686 agmatinase; Region: agmatinase; TIGR01230 999891010687 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 999891010688 putative active site [active] 999891010689 Mn binding site [ion binding]; other site 999891010690 spermidine synthase; Provisional; Region: PRK00811 999891010691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 999891010692 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 999891010693 Transglycosylase; Region: Transgly; pfam00912 999891010694 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 999891010695 YwhD family; Region: YwhD; pfam08741 999891010696 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 999891010697 Peptidase family M50; Region: Peptidase_M50; pfam02163 999891010698 active site 999891010699 putative substrate binding region [chemical binding]; other site 999891010700 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 999891010701 active site 1 [active] 999891010702 dimer interface [polypeptide binding]; other site 999891010703 hexamer interface [polypeptide binding]; other site 999891010704 active site 2 [active] 999891010705 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891010706 dimerization interface [polypeptide binding]; other site 999891010707 putative DNA binding site [nucleotide binding]; other site 999891010708 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891010709 putative Zn2+ binding site [ion binding]; other site 999891010710 amino acid transporter; Region: 2A0306; TIGR00909 999891010711 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 999891010712 Uncharacterized conserved protein [Function unknown]; Region: COG3465 999891010713 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 999891010714 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 999891010715 Zn2+ binding site [ion binding]; other site 999891010716 Mg2+ binding site [ion binding]; other site 999891010717 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 999891010718 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 999891010719 Predicted transcriptional regulators [Transcription]; Region: COG1695 999891010720 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 999891010721 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 999891010722 potential frameshift: common BLAST hit: gi|308175480|ref|YP_003922185.1| ABC transporter ATP-binding protein; RBAM_034760 999891010723 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 999891010724 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 999891010725 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 999891010726 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999891010727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999891010728 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 999891010729 putative dimerization interface [polypeptide binding]; other site 999891010730 Predicted membrane protein [Function unknown]; Region: COG2855 999891010731 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 999891010732 putative heme peroxidase; Provisional; Region: PRK12276 999891010733 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 999891010734 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 999891010735 putative NAD(P) binding site [chemical binding]; other site 999891010736 putative active site [active] 999891010737 transaminase; Reviewed; Region: PRK08068 999891010738 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891010739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891010740 homodimer interface [polypeptide binding]; other site 999891010741 catalytic residue [active] 999891010742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891010743 H+ Antiporter protein; Region: 2A0121; TIGR00900 999891010744 putative substrate translocation pore; other site 999891010745 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 999891010746 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 999891010747 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 999891010748 classical (c) SDRs; Region: SDR_c; cd05233 999891010749 NAD(P) binding site [chemical binding]; other site 999891010750 active site 999891010751 Cupin domain; Region: Cupin_2; pfam07883 999891010752 Cupin domain; Region: Cupin_2; pfam07883 999891010753 Prephenate dehydratase; Region: PDT; pfam00800 999891010754 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 999891010755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891010756 putative substrate translocation pore; other site 999891010757 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 999891010758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891010759 putative substrate translocation pore; other site 999891010760 S-methylmethionine transporter; Provisional; Region: PRK11387 999891010761 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 999891010762 putative metal binding site [ion binding]; other site 999891010763 putative dimer interface [polypeptide binding]; other site 999891010764 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 999891010765 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 999891010766 Glutamate binding site [chemical binding]; other site 999891010767 homodimer interface [polypeptide binding]; other site 999891010768 NAD binding site [chemical binding]; other site 999891010769 catalytic residues [active] 999891010770 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 999891010771 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 999891010772 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 999891010773 NAD(P) binding site [chemical binding]; other site 999891010774 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 999891010775 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 999891010776 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 999891010777 NADP binding site [chemical binding]; other site 999891010778 active site 999891010779 putative substrate binding site [chemical binding]; other site 999891010780 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 999891010781 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 999891010782 NAD binding site [chemical binding]; other site 999891010783 substrate binding site [chemical binding]; other site 999891010784 homodimer interface [polypeptide binding]; other site 999891010785 active site 999891010786 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 999891010787 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 999891010788 substrate binding site; other site 999891010789 tetramer interface; other site 999891010790 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 999891010791 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 999891010792 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 999891010793 ligand binding site; other site 999891010794 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 999891010795 NeuB family; Region: NeuB; pfam03102 999891010796 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 999891010797 NeuB binding interface [polypeptide binding]; other site 999891010798 putative substrate binding site [chemical binding]; other site 999891010799 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 999891010800 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 999891010801 Coenzyme A binding pocket [chemical binding]; other site 999891010802 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 999891010803 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 999891010804 inhibitor-cofactor binding pocket; inhibition site 999891010805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891010806 catalytic residue [active] 999891010807 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 999891010808 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 999891010809 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 999891010810 active site 999891010811 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 999891010812 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 999891010813 Permease family; Region: Xan_ur_permease; pfam00860 999891010814 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 999891010815 ligand binding site [chemical binding]; other site 999891010816 active site 999891010817 UGI interface [polypeptide binding]; other site 999891010818 catalytic site [active] 999891010819 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 999891010820 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 999891010821 active site 999891010822 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 999891010823 dimer interface [polypeptide binding]; other site 999891010824 substrate binding site [chemical binding]; other site 999891010825 ATP binding site [chemical binding]; other site 999891010826 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 999891010827 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 999891010828 substrate binding [chemical binding]; other site 999891010829 active site 999891010830 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 999891010831 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 999891010832 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 999891010833 active site turn [active] 999891010834 phosphorylation site [posttranslational modification] 999891010835 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 999891010836 transcriptional antiterminator BglG; Provisional; Region: PRK09772 999891010837 CAT RNA binding domain; Region: CAT_RBD; smart01061 999891010838 PRD domain; Region: PRD; pfam00874 999891010839 PRD domain; Region: PRD; pfam00874 999891010840 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 999891010841 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 999891010842 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 999891010843 putative active site [active] 999891010844 catalytic triad [active] 999891010845 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 999891010846 PA/protease domain interface [polypeptide binding]; other site 999891010847 putative integrin binding motif; other site 999891010848 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 999891010849 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 999891010850 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 999891010851 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 999891010852 Predicted transcriptional regulator [Transcription]; Region: COG2378 999891010853 HTH domain; Region: HTH_11; pfam08279 999891010854 WYL domain; Region: WYL; pfam13280 999891010855 short chain dehydrogenase; Provisional; Region: PRK06523 999891010856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 999891010857 NAD(P) binding site [chemical binding]; other site 999891010858 active site 999891010859 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 999891010860 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 999891010861 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 999891010862 dimer interface [polypeptide binding]; other site 999891010863 FMN binding site [chemical binding]; other site 999891010864 NADPH bind site [chemical binding]; other site 999891010865 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 999891010866 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 999891010867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891010868 Coenzyme A binding pocket [chemical binding]; other site 999891010869 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 999891010870 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 999891010871 Subunit I/III interface [polypeptide binding]; other site 999891010872 Subunit III/IV interface [polypeptide binding]; other site 999891010873 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 999891010874 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 999891010875 D-pathway; other site 999891010876 Putative ubiquinol binding site [chemical binding]; other site 999891010877 Low-spin heme (heme b) binding site [chemical binding]; other site 999891010878 Putative water exit pathway; other site 999891010879 Binuclear center (heme o3/CuB) [ion binding]; other site 999891010880 K-pathway; other site 999891010881 Putative proton exit pathway; other site 999891010882 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 999891010883 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 999891010884 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 999891010885 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 999891010886 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 999891010887 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 999891010888 galactokinase; Provisional; Region: PRK05322 999891010889 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 999891010890 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 999891010891 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 999891010892 Predicted membrane protein [Function unknown]; Region: COG2246 999891010893 GtrA-like protein; Region: GtrA; pfam04138 999891010894 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891010895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891010896 Uso1 / p115 like vesicle tethering protein, head region; Region: Uso1_p115_head; pfam04869 999891010897 Anti-repressor SinI; Region: SinI; pfam08671 999891010898 Methyltransferase domain; Region: Methyltransf_23; pfam13489 999891010899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891010900 S-adenosylmethionine binding site [chemical binding]; other site 999891010901 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 999891010902 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 999891010903 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 999891010904 catalytic residues [active] 999891010905 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 999891010906 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 999891010907 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 999891010908 Imelysin; Region: Peptidase_M75; pfam09375 999891010909 FTR1 family protein; Region: TIGR00145 999891010910 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 999891010911 thiamine phosphate binding site [chemical binding]; other site 999891010912 active site 999891010913 pyrophosphate binding site [ion binding]; other site 999891010914 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 999891010915 substrate binding site [chemical binding]; other site 999891010916 multimerization interface [polypeptide binding]; other site 999891010917 ATP binding site [chemical binding]; other site 999891010918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 999891010919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 999891010920 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 999891010921 putative dimerization interface [polypeptide binding]; other site 999891010922 holin-like protein; Validated; Region: PRK01658 999891010923 LrgB-like family; Region: LrgB; cl00596 999891010924 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 999891010925 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 999891010926 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 999891010927 DNA binding residues [nucleotide binding] 999891010928 dimer interface [polypeptide binding]; other site 999891010929 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 999891010930 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 999891010931 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 999891010932 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 999891010933 putative RNA binding site [nucleotide binding]; other site 999891010934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891010935 S-adenosylmethionine binding site [chemical binding]; other site 999891010936 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 999891010937 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 999891010938 active site 999891010939 metal binding site [ion binding]; metal-binding site 999891010940 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 999891010941 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 999891010942 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 999891010943 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 999891010944 active site 999891010945 catalytic residues [active] 999891010946 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 999891010947 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 999891010948 Ligand binding site; other site 999891010949 metal-binding site 999891010950 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 999891010951 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 999891010952 synthetase active site [active] 999891010953 NTP binding site [chemical binding]; other site 999891010954 metal binding site [ion binding]; metal-binding site 999891010955 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 999891010956 UbiA prenyltransferase family; Region: UbiA; pfam01040 999891010957 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 999891010958 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 999891010959 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 999891010960 acyl-activating enzyme (AAE) consensus motif; other site 999891010961 AMP binding site [chemical binding]; other site 999891010962 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 999891010963 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 999891010964 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 999891010965 DltD N-terminal region; Region: DltD_N; pfam04915 999891010966 DltD central region; Region: DltD_M; pfam04918 999891010967 DltD C-terminal region; Region: DltD_C; pfam04914 999891010968 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 999891010969 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 999891010970 homodimer interface [polypeptide binding]; other site 999891010971 substrate-cofactor binding pocket; other site 999891010972 catalytic residue [active] 999891010973 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 999891010974 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 999891010975 NAD binding site [chemical binding]; other site 999891010976 sugar binding site [chemical binding]; other site 999891010977 divalent metal binding site [ion binding]; other site 999891010978 tetramer (dimer of dimers) interface [polypeptide binding]; other site 999891010979 dimer interface [polypeptide binding]; other site 999891010980 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 999891010981 methionine cluster; other site 999891010982 active site 999891010983 phosphorylation site [posttranslational modification] 999891010984 metal binding site [ion binding]; metal-binding site 999891010985 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 999891010986 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 999891010987 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 999891010988 active site 999891010989 P-loop; other site 999891010990 phosphorylation site [posttranslational modification] 999891010991 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 999891010992 HTH domain; Region: HTH_11; pfam08279 999891010993 Mga helix-turn-helix domain; Region: Mga; pfam05043 999891010994 PRD domain; Region: PRD; pfam00874 999891010995 PRD domain; Region: PRD; pfam00874 999891010996 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 999891010997 active site 999891010998 P-loop; other site 999891010999 phosphorylation site [posttranslational modification] 999891011000 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 999891011001 active site 999891011002 phosphorylation site [posttranslational modification] 999891011003 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 999891011004 active site 999891011005 DNA binding site [nucleotide binding] 999891011006 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 999891011007 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 999891011008 ABC-ATPase subunit interface; other site 999891011009 dimer interface [polypeptide binding]; other site 999891011010 putative PBP binding regions; other site 999891011011 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 999891011012 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 999891011013 ABC-ATPase subunit interface; other site 999891011014 dimer interface [polypeptide binding]; other site 999891011015 putative PBP binding regions; other site 999891011016 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 999891011017 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 999891011018 intersubunit interface [polypeptide binding]; other site 999891011019 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891011020 dimerization interface [polypeptide binding]; other site 999891011021 putative DNA binding site [nucleotide binding]; other site 999891011022 putative Zn2+ binding site [ion binding]; other site 999891011023 arsenical pump membrane protein; Provisional; Region: PRK15445 999891011024 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 999891011025 transmembrane helices; other site 999891011026 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 999891011027 active site 999891011028 P-loop; other site 999891011029 phosphorylation site [posttranslational modification] 999891011030 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 999891011031 active site 999891011032 methionine cluster; other site 999891011033 phosphorylation site [posttranslational modification] 999891011034 metal binding site [ion binding]; metal-binding site 999891011035 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 999891011036 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 999891011037 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 999891011038 beta-galactosidase; Region: BGL; TIGR03356 999891011039 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 999891011040 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 999891011041 nucleotide binding site [chemical binding]; other site 999891011042 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 999891011043 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 999891011044 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 999891011045 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 999891011046 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 999891011047 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 999891011048 tetramer interface [polypeptide binding]; other site 999891011049 heme binding pocket [chemical binding]; other site 999891011050 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 999891011051 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 999891011052 active site 999891011053 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 999891011054 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 999891011055 Na binding site [ion binding]; other site 999891011056 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 999891011057 putative substrate binding site [chemical binding]; other site 999891011058 putative ATP binding site [chemical binding]; other site 999891011059 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 999891011060 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999891011061 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 999891011062 Walker A/P-loop; other site 999891011063 ATP binding site [chemical binding]; other site 999891011064 Q-loop/lid; other site 999891011065 ABC transporter signature motif; other site 999891011066 Walker B; other site 999891011067 D-loop; other site 999891011068 H-loop/switch region; other site 999891011069 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 999891011070 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 999891011071 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891011072 ATP binding site [chemical binding]; other site 999891011073 Q-loop/lid; other site 999891011074 ABC transporter signature motif; other site 999891011075 Walker B; other site 999891011076 D-loop; other site 999891011077 H-loop/switch region; other site 999891011078 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 999891011079 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 999891011080 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 999891011081 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 999891011082 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 999891011083 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 999891011084 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 999891011085 putative active site [active] 999891011086 putative metal binding site [ion binding]; other site 999891011087 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 999891011088 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 999891011089 Walker A/P-loop; other site 999891011090 ATP binding site [chemical binding]; other site 999891011091 Q-loop/lid; other site 999891011092 ABC transporter signature motif; other site 999891011093 Walker B; other site 999891011094 D-loop; other site 999891011095 H-loop/switch region; other site 999891011096 TOBE domain; Region: TOBE; pfam03459 999891011097 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 999891011098 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 999891011099 Uncharacterized conserved protein [Function unknown]; Region: COG1284 999891011100 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999891011101 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 999891011102 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 999891011103 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 999891011104 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 999891011105 UDP-glucose 4-epimerase; Region: PLN02240 999891011106 NAD binding site [chemical binding]; other site 999891011107 homodimer interface [polypeptide binding]; other site 999891011108 active site 999891011109 substrate binding site [chemical binding]; other site 999891011110 peptidase T; Region: peptidase-T; TIGR01882 999891011111 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 999891011112 metal binding site [ion binding]; metal-binding site 999891011113 dimer interface [polypeptide binding]; other site 999891011114 Tubby C 2; Region: Tub_2; cl02043 999891011115 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 999891011116 substrate binding site [chemical binding]; other site 999891011117 THF binding site; other site 999891011118 zinc-binding site [ion binding]; other site 999891011119 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 999891011120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891011121 S-adenosylmethionine binding site [chemical binding]; other site 999891011122 nucleoside transporter; Region: nupC; TIGR00804 999891011123 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 999891011124 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 999891011125 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 999891011126 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 999891011127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 999891011128 ABC transporter signature motif; other site 999891011129 Walker B; other site 999891011130 D-loop; other site 999891011131 H-loop/switch region; other site 999891011132 hydroperoxidase II; Provisional; Region: katE; PRK11249 999891011133 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 999891011134 tetramer interface [polypeptide binding]; other site 999891011135 heme binding pocket [chemical binding]; other site 999891011136 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 999891011137 domain interactions; other site 999891011138 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 999891011139 Citrate transporter; Region: CitMHS; pfam03600 999891011140 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 999891011141 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 999891011142 active site 999891011143 active site 999891011144 catalytic residues [active] 999891011145 transcriptional antiterminator BglG; Provisional; Region: PRK09772 999891011146 CAT RNA binding domain; Region: CAT_RBD; smart01061 999891011147 PRD domain; Region: PRD; pfam00874 999891011148 PRD domain; Region: PRD; pfam00874 999891011149 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 999891011150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891011151 putative substrate translocation pore; other site 999891011152 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 999891011153 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 999891011154 ATP binding site [chemical binding]; other site 999891011155 Mg++ binding site [ion binding]; other site 999891011156 motif III; other site 999891011157 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 999891011158 nucleotide binding region [chemical binding]; other site 999891011159 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 999891011160 RNA binding site [nucleotide binding]; other site 999891011161 YxiJ-like protein; Region: YxiJ; pfam14176 999891011162 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 999891011163 Amb_all domain; Region: Amb_all; smart00656 999891011164 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 999891011165 EamA-like transporter family; Region: EamA; pfam00892 999891011166 EamA-like transporter family; Region: EamA; pfam00892 999891011167 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 999891011168 Ligand Binding Site [chemical binding]; other site 999891011169 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 999891011170 beta-galactosidase; Region: BGL; TIGR03356 999891011171 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 999891011172 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 999891011173 active site turn [active] 999891011174 phosphorylation site [posttranslational modification] 999891011175 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 999891011176 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 999891011177 HPr interaction site; other site 999891011178 glycerol kinase (GK) interaction site [polypeptide binding]; other site 999891011179 active site 999891011180 phosphorylation site [posttranslational modification] 999891011181 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 999891011182 additional DNA contacts [nucleotide binding]; other site 999891011183 mismatch recognition site; other site 999891011184 active site 999891011185 zinc binding site [ion binding]; other site 999891011186 DNA intercalation site [nucleotide binding]; other site 999891011187 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 999891011188 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 999891011189 cofactor binding site; other site 999891011190 DNA binding site [nucleotide binding] 999891011191 substrate interaction site [chemical binding]; other site 999891011192 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 999891011193 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 999891011194 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 999891011195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891011196 ATP binding site [chemical binding]; other site 999891011197 G-X-G motif; other site 999891011198 Z1 domain; Region: Z1; pfam10593 999891011199 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 999891011200 potential frameshift: common BLAST hit: gi|308175646|ref|YP_003922351.1| AIPR protein 999891011201 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 999891011202 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 999891011203 substrate binding site [chemical binding]; other site 999891011204 active site 999891011205 anti-terminator HutP; Provisional; Region: hutP; PRK03065 999891011206 RNA binding site [nucleotide binding]; other site 999891011207 hexamer interface [polypeptide binding]; other site 999891011208 Histidine-zinc binding site [chemical binding]; other site 999891011209 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 999891011210 active sites [active] 999891011211 tetramer interface [polypeptide binding]; other site 999891011212 urocanate hydratase; Provisional; Region: PRK05414 999891011213 imidazolonepropionase; Validated; Region: PRK09356 999891011214 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 999891011215 active site 999891011216 Agmatinase-like family; Region: Agmatinase-like; cd09990 999891011217 agmatinase; Region: agmatinase; TIGR01230 999891011218 active site 999891011219 oligomer interface [polypeptide binding]; other site 999891011220 Mn binding site [ion binding]; other site 999891011221 S-methylmethionine transporter; Provisional; Region: PRK11387 999891011222 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 999891011223 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 999891011224 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 999891011225 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 999891011226 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 999891011227 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 999891011228 Nucleoside recognition; Region: Gate; pfam07670 999891011229 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 999891011230 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 999891011231 intersubunit interface [polypeptide binding]; other site 999891011232 active site 999891011233 catalytic residue [active] 999891011234 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 999891011235 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 999891011236 non-specific DNA interactions [nucleotide binding]; other site 999891011237 DNA binding site [nucleotide binding] 999891011238 sequence specific DNA binding site [nucleotide binding]; other site 999891011239 putative cAMP binding site [chemical binding]; other site 999891011240 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 999891011241 sugar phosphate phosphatase; Provisional; Region: PRK10513 999891011242 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891011243 active site 999891011244 motif I; other site 999891011245 motif II; other site 999891011246 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 999891011247 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 999891011248 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 999891011249 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 999891011250 putative ligand binding residues [chemical binding]; other site 999891011251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 999891011252 FtsX-like permease family; Region: FtsX; pfam02687 999891011253 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 999891011254 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 999891011255 Walker A/P-loop; other site 999891011256 ATP binding site [chemical binding]; other site 999891011257 Q-loop/lid; other site 999891011258 ABC transporter signature motif; other site 999891011259 Walker B; other site 999891011260 D-loop; other site 999891011261 H-loop/switch region; other site 999891011262 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999891011263 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 999891011264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891011265 ATP binding site [chemical binding]; other site 999891011266 Mg2+ binding site [ion binding]; other site 999891011267 G-X-G motif; other site 999891011268 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999891011269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891011270 active site 999891011271 phosphorylation site [posttranslational modification] 999891011272 intermolecular recognition site; other site 999891011273 dimerization interface [polypeptide binding]; other site 999891011274 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999891011275 DNA binding site [nucleotide binding] 999891011276 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 999891011277 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 999891011278 intersubunit interface [polypeptide binding]; other site 999891011279 active site 999891011280 zinc binding site [ion binding]; other site 999891011281 Na+ binding site [ion binding]; other site 999891011282 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 999891011283 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 999891011284 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 999891011285 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 999891011286 DNA interaction; other site 999891011287 Metal-binding active site; metal-binding site 999891011288 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 999891011289 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 999891011290 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 999891011291 Glucuronate isomerase; Region: UxaC; cl00829 999891011292 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891011293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891011294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891011295 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 999891011296 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 999891011297 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 999891011298 PYR/PP interface [polypeptide binding]; other site 999891011299 dimer interface [polypeptide binding]; other site 999891011300 TPP binding site [chemical binding]; other site 999891011301 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 999891011302 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 999891011303 TPP-binding site; other site 999891011304 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 999891011305 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 999891011306 substrate binding site [chemical binding]; other site 999891011307 ATP binding site [chemical binding]; other site 999891011308 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 999891011309 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 999891011310 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 999891011311 tetrameric interface [polypeptide binding]; other site 999891011312 NAD binding site [chemical binding]; other site 999891011313 catalytic residues [active] 999891011314 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 999891011315 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 999891011316 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 999891011317 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999891011318 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999891011319 active site 999891011320 catalytic tetrad [active] 999891011321 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 999891011322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891011323 putative substrate translocation pore; other site 999891011324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891011325 heat shock protein 90; Provisional; Region: PRK05218 999891011326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891011327 ATP binding site [chemical binding]; other site 999891011328 Mg2+ binding site [ion binding]; other site 999891011329 G-X-G motif; other site 999891011330 short chain dehydrogenase; Validated; Region: PRK08589 999891011331 classical (c) SDRs; Region: SDR_c; cd05233 999891011332 NAD(P) binding site [chemical binding]; other site 999891011333 active site 999891011334 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 999891011335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891011336 active site 999891011337 phosphorylation site [posttranslational modification] 999891011338 intermolecular recognition site; other site 999891011339 dimerization interface [polypeptide binding]; other site 999891011340 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 999891011341 DNA binding residues [nucleotide binding] 999891011342 dimerization interface [polypeptide binding]; other site 999891011343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 999891011344 Histidine kinase; Region: HisKA_3; pfam07730 999891011345 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 999891011346 ATP binding site [chemical binding]; other site 999891011347 Mg2+ binding site [ion binding]; other site 999891011348 G-X-G motif; other site 999891011349 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 999891011350 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 999891011351 putative di-iron ligands [ion binding]; other site 999891011352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891011353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891011354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 999891011355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 999891011356 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 999891011357 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 999891011358 NAD(P) binding site [chemical binding]; other site 999891011359 catalytic residues [active] 999891011360 FOG: WD40-like repeat [Function unknown]; Region: COG1520 999891011361 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 999891011362 Trp docking motif [polypeptide binding]; other site 999891011363 active site 999891011364 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891011365 putative DNA binding site [nucleotide binding]; other site 999891011366 dimerization interface [polypeptide binding]; other site 999891011367 putative Zn2+ binding site [ion binding]; other site 999891011368 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 999891011369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891011370 putative substrate translocation pore; other site 999891011371 RDD family; Region: RDD; pfam06271 999891011372 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 999891011373 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 999891011374 active site 999891011375 peroxiredoxin; Region: AhpC; TIGR03137 999891011376 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 999891011377 dimer interface [polypeptide binding]; other site 999891011378 decamer (pentamer of dimers) interface [polypeptide binding]; other site 999891011379 catalytic triad [active] 999891011380 peroxidatic and resolving cysteines [active] 999891011381 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 999891011382 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 999891011383 catalytic residue [active] 999891011384 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 999891011385 catalytic residues [active] 999891011386 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 999891011387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 999891011388 Major royal jelly protein; Region: MRJP; pfam03022 999891011389 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 999891011390 HTH domain; Region: HTH_11; pfam08279 999891011391 WYL domain; Region: WYL; pfam13280 999891011392 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 999891011393 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 999891011394 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 999891011395 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 999891011396 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 999891011397 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 999891011398 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 999891011399 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 999891011400 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 999891011401 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 999891011402 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 999891011403 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 999891011404 Ligand binding site; other site 999891011405 metal-binding site 999891011406 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 999891011407 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 999891011408 XdhC Rossmann domain; Region: XdhC_C; pfam13478 999891011409 Predicted membrane protein [Function unknown]; Region: COG4129 999891011410 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 999891011411 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 999891011412 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 999891011413 Part of AAA domain; Region: AAA_19; pfam13245 999891011414 AAA ATPase domain; Region: AAA_15; pfam13175 999891011415 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 999891011416 putative active site [active] 999891011417 putative metal-binding site [ion binding]; other site 999891011418 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 999891011419 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 999891011420 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 999891011421 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 999891011422 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 999891011423 active site 999891011424 catalytic tetrad [active] 999891011425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 999891011426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891011427 Coenzyme A binding pocket [chemical binding]; other site 999891011428 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891011429 Tetratricopeptide repeat; Region: TPR_12; pfam13424 999891011430 Arginase family; Region: Arginase; cd09989 999891011431 agmatinase; Region: agmatinase; TIGR01230 999891011432 active site 999891011433 Mn binding site [ion binding]; other site 999891011434 oligomer interface [polypeptide binding]; other site 999891011435 S-methylmethionine transporter; Provisional; Region: PRK11387 999891011436 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 999891011437 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 999891011438 inhibitor-cofactor binding pocket; inhibition site 999891011439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891011440 catalytic residue [active] 999891011441 Predicted integral membrane protein [Function unknown]; Region: COG5658 999891011442 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 999891011443 SdpI/YhfL protein family; Region: SdpI; pfam13630 999891011444 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891011445 dimerization interface [polypeptide binding]; other site 999891011446 putative DNA binding site [nucleotide binding]; other site 999891011447 putative Zn2+ binding site [ion binding]; other site 999891011448 PAS domain; Region: PAS_9; pfam13426 999891011449 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 999891011450 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 999891011451 Walker A motif; other site 999891011452 ATP binding site [chemical binding]; other site 999891011453 Walker B motif; other site 999891011454 arginine finger; other site 999891011455 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 999891011456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891011457 putative substrate translocation pore; other site 999891011458 Major Facilitator Superfamily; Region: MFS_1; pfam07690 999891011459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 999891011460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 999891011461 dimerization interface [polypeptide binding]; other site 999891011462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891011463 dimer interface [polypeptide binding]; other site 999891011464 phosphorylation site [posttranslational modification] 999891011465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891011466 ATP binding site [chemical binding]; other site 999891011467 Mg2+ binding site [ion binding]; other site 999891011468 G-X-G motif; other site 999891011469 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999891011470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891011471 active site 999891011472 phosphorylation site [posttranslational modification] 999891011473 intermolecular recognition site; other site 999891011474 dimerization interface [polypeptide binding]; other site 999891011475 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999891011476 DNA binding site [nucleotide binding] 999891011477 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 999891011478 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 999891011479 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 999891011480 Predicted membrane protein [Function unknown]; Region: COG3212 999891011481 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 999891011482 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 999891011483 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 999891011484 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 999891011485 protein binding site [polypeptide binding]; other site 999891011486 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 999891011487 YycH protein; Region: YycI; cl02015 999891011488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 999891011489 YycH protein; Region: YycH; pfam07435 999891011490 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 999891011491 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 999891011492 dimerization interface [polypeptide binding]; other site 999891011493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 999891011494 putative active site [active] 999891011495 heme pocket [chemical binding]; other site 999891011496 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 999891011497 dimer interface [polypeptide binding]; other site 999891011498 phosphorylation site [posttranslational modification] 999891011499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 999891011500 ATP binding site [chemical binding]; other site 999891011501 Mg2+ binding site [ion binding]; other site 999891011502 G-X-G motif; other site 999891011503 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 999891011504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 999891011505 active site 999891011506 phosphorylation site [posttranslational modification] 999891011507 intermolecular recognition site; other site 999891011508 dimerization interface [polypeptide binding]; other site 999891011509 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 999891011510 DNA binding site [nucleotide binding] 999891011511 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 999891011512 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 999891011513 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 999891011514 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 999891011515 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 999891011516 active site 999891011517 replicative DNA helicase; Provisional; Region: PRK05748 999891011518 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 999891011519 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 999891011520 Walker A motif; other site 999891011521 ATP binding site [chemical binding]; other site 999891011522 Walker B motif; other site 999891011523 DNA binding loops [nucleotide binding] 999891011524 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 999891011525 YycC-like protein; Region: YycC; pfam14174 999891011526 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 999891011527 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 999891011528 Phosphotransferase enzyme family; Region: APH; pfam01636 999891011529 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 999891011530 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 999891011531 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 999891011532 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 999891011533 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 999891011534 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 999891011535 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 999891011536 active site 999891011537 substrate binding site [chemical binding]; other site 999891011538 ATP binding site [chemical binding]; other site 999891011539 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 999891011540 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 999891011541 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 999891011542 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 999891011543 diguanylate cyclase; Region: GGDEF; smart00267 999891011544 DHH family; Region: DHH; pfam01368 999891011545 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 999891011546 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 999891011547 Predicted transcriptional regulators [Transcription]; Region: COG1733 999891011548 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 999891011549 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 999891011550 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 999891011551 DHHA2 domain; Region: DHHA2; pfam02833 999891011552 EamA-like transporter family; Region: EamA; pfam00892 999891011553 EamA-like transporter family; Region: EamA; pfam00892 999891011554 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 999891011555 active site 999891011556 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 999891011557 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 999891011558 substrate binding [chemical binding]; other site 999891011559 active site 999891011560 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 999891011561 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 999891011562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891011563 DNA-binding site [nucleotide binding]; DNA binding site 999891011564 FCD domain; Region: FCD; pfam07729 999891011565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 999891011566 H+ Antiporter protein; Region: 2A0121; TIGR00900 999891011567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 999891011568 putative substrate translocation pore; other site 999891011569 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 999891011570 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 999891011571 dimer interface [polypeptide binding]; other site 999891011572 FMN binding site [chemical binding]; other site 999891011573 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891011574 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 999891011575 putative DNA binding site [nucleotide binding]; other site 999891011576 putative Zn2+ binding site [ion binding]; other site 999891011577 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 999891011578 Uncharacterized conserved protein [Function unknown]; Region: COG1284 999891011579 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 999891011580 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 999891011581 MarR family; Region: MarR; pfam01047 999891011582 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 999891011583 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891011584 Coenzyme A binding pocket [chemical binding]; other site 999891011585 DinB family; Region: DinB; cl17821 999891011586 DinB superfamily; Region: DinB_2; pfam12867 999891011587 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 999891011588 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 999891011589 DNA-binding site [nucleotide binding]; DNA binding site 999891011590 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 999891011591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 999891011592 homodimer interface [polypeptide binding]; other site 999891011593 catalytic residue [active] 999891011594 EamA-like transporter family; Region: EamA; pfam00892 999891011595 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 999891011596 EamA-like transporter family; Region: EamA; pfam00892 999891011597 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 999891011598 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 999891011599 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 999891011600 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 999891011601 putative active site [active] 999891011602 putative NTP binding site [chemical binding]; other site 999891011603 putative nucleic acid binding site [nucleotide binding]; other site 999891011604 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 999891011605 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 999891011606 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 999891011607 catalytic residues [active] 999891011608 CAAX protease self-immunity; Region: Abi; pfam02517 999891011609 benzoate transport; Region: 2A0115; TIGR00895 999891011610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891011611 putative substrate translocation pore; other site 999891011612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 999891011613 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 999891011614 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 999891011615 putative metal binding site [ion binding]; other site 999891011616 Transcriptional regulators [Transcription]; Region: PurR; COG1609 999891011617 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 999891011618 DNA binding site [nucleotide binding] 999891011619 domain linker motif; other site 999891011620 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 999891011621 putative dimerization interface [polypeptide binding]; other site 999891011622 putative ligand binding site [chemical binding]; other site 999891011623 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 999891011624 active site 999891011625 putative catalytic site [active] 999891011626 DNA binding site [nucleotide binding] 999891011627 putative phosphate binding site [ion binding]; other site 999891011628 metal binding site A [ion binding]; metal-binding site 999891011629 AP binding site [nucleotide binding]; other site 999891011630 metal binding site B [ion binding]; metal-binding site 999891011631 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 999891011632 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 999891011633 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 999891011634 DNA binding site [nucleotide binding] 999891011635 active site 999891011636 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 999891011637 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 999891011638 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 999891011639 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 999891011640 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 999891011641 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 999891011642 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 999891011643 dimer interface [polypeptide binding]; other site 999891011644 ssDNA binding site [nucleotide binding]; other site 999891011645 tetramer (dimer of dimers) interface [polypeptide binding]; other site 999891011646 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 999891011647 GTP-binding protein YchF; Reviewed; Region: PRK09601 999891011648 YchF GTPase; Region: YchF; cd01900 999891011649 G1 box; other site 999891011650 GTP/Mg2+ binding site [chemical binding]; other site 999891011651 Switch I region; other site 999891011652 G2 box; other site 999891011653 Switch II region; other site 999891011654 G3 box; other site 999891011655 G4 box; other site 999891011656 G5 box; other site 999891011657 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 999891011658 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 999891011659 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 999891011660 putative [4Fe-4S] binding site [ion binding]; other site 999891011661 putative molybdopterin cofactor binding site [chemical binding]; other site 999891011662 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 999891011663 molybdopterin cofactor binding site; other site 999891011664 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 999891011665 Uncharacterized membrane protein [Function unknown]; Region: COG3949 999891011666 Spore germination protein; Region: Spore_permease; cl17796 999891011667 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 999891011668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 999891011669 Coenzyme A binding pocket [chemical binding]; other site 999891011670 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 999891011671 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 999891011672 ParB-like nuclease domain; Region: ParB; smart00470 999891011673 KorB domain; Region: KorB; pfam08535 999891011674 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 999891011675 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 999891011676 P-loop; other site 999891011677 Magnesium ion binding site [ion binding]; other site 999891011678 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 999891011679 Magnesium ion binding site [ion binding]; other site 999891011680 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 999891011681 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 999891011682 ParB-like nuclease domain; Region: ParB; smart00470 999891011683 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 999891011684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 999891011685 S-adenosylmethionine binding site [chemical binding]; other site 999891011686 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 999891011687 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 999891011688 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 999891011689 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 999891011690 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 999891011691 trmE is a tRNA modification GTPase; Region: trmE; cd04164 999891011692 G1 box; other site 999891011693 GTP/Mg2+ binding site [chemical binding]; other site 999891011694 Switch I region; other site 999891011695 G2 box; other site 999891011696 Switch II region; other site 999891011697 G3 box; other site 999891011698 G4 box; other site 999891011699 G5 box; other site 999891011700 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 999891011701 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 999891011702 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 999891011703 G-X-X-G motif; other site 999891011704 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 999891011705 RxxxH motif; other site 999891011706 OxaA-like protein precursor; Validated; Region: PRK02944 999891011707 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 999891011708 ribonuclease P; Reviewed; Region: rnpA; PRK00499 999891011709 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399