-- dump date 20140618_211858 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1126211000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1126211000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1126211000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211000004 Walker A motif; other site 1126211000005 ATP binding site [chemical binding]; other site 1126211000006 Walker B motif; other site 1126211000007 arginine finger; other site 1126211000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1126211000009 DnaA box-binding interface [nucleotide binding]; other site 1126211000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1126211000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1126211000012 putative DNA binding surface [nucleotide binding]; other site 1126211000013 dimer interface [polypeptide binding]; other site 1126211000014 beta-clamp/clamp loader binding surface; other site 1126211000015 beta-clamp/translesion DNA polymerase binding surface; other site 1126211000016 S4 domain; Region: S4_2; pfam13275 1126211000017 recombination protein F; Reviewed; Region: recF; PRK00064 1126211000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1126211000019 Walker A/P-loop; other site 1126211000020 ATP binding site [chemical binding]; other site 1126211000021 Q-loop/lid; other site 1126211000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211000023 ABC transporter signature motif; other site 1126211000024 Walker B; other site 1126211000025 D-loop; other site 1126211000026 H-loop/switch region; other site 1126211000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1126211000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211000029 ATP binding site [chemical binding]; other site 1126211000030 Mg2+ binding site [ion binding]; other site 1126211000031 G-X-G motif; other site 1126211000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1126211000033 anchoring element; other site 1126211000034 dimer interface [polypeptide binding]; other site 1126211000035 ATP binding site [chemical binding]; other site 1126211000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1126211000037 active site 1126211000038 putative metal-binding site [ion binding]; other site 1126211000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1126211000040 DNA gyrase subunit A; Validated; Region: PRK05560 1126211000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1126211000042 CAP-like domain; other site 1126211000043 active site 1126211000044 primary dimer interface [polypeptide binding]; other site 1126211000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1126211000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1126211000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1126211000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1126211000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1126211000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1126211000051 YaaC-like Protein; Region: YaaC; pfam14175 1126211000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1126211000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1126211000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1126211000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1126211000056 active site 1126211000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1126211000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1126211000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1126211000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1126211000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1126211000062 active site 1126211000063 multimer interface [polypeptide binding]; other site 1126211000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1126211000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1126211000066 predicted active site [active] 1126211000067 catalytic triad [active] 1126211000068 seryl-tRNA synthetase; Provisional; Region: PRK05431 1126211000069 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1126211000070 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1126211000071 dimer interface [polypeptide binding]; other site 1126211000072 active site 1126211000073 motif 1; other site 1126211000074 motif 2; other site 1126211000075 motif 3; other site 1126211000076 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1126211000077 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1126211000078 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1126211000079 Substrate-binding site [chemical binding]; other site 1126211000080 Substrate specificity [chemical binding]; other site 1126211000081 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1126211000082 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1126211000083 Substrate-binding site [chemical binding]; other site 1126211000084 Substrate specificity [chemical binding]; other site 1126211000085 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1126211000086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211000087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211000088 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1126211000089 active site 1126211000090 Isochorismatase family; Region: Isochorismatase; pfam00857 1126211000091 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1126211000092 catalytic triad [active] 1126211000093 conserved cis-peptide bond; other site 1126211000094 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1126211000095 nucleoside/Zn binding site; other site 1126211000096 dimer interface [polypeptide binding]; other site 1126211000097 catalytic motif [active] 1126211000098 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1126211000099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211000100 Walker A motif; other site 1126211000101 ATP binding site [chemical binding]; other site 1126211000102 Walker B motif; other site 1126211000103 arginine finger; other site 1126211000104 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1126211000105 hypothetical protein; Validated; Region: PRK00153 1126211000106 recombination protein RecR; Reviewed; Region: recR; PRK00076 1126211000107 RecR protein; Region: RecR; pfam02132 1126211000108 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1126211000109 putative active site [active] 1126211000110 putative metal-binding site [ion binding]; other site 1126211000111 tetramer interface [polypeptide binding]; other site 1126211000112 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1126211000113 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 1126211000114 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1126211000115 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 1126211000116 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1126211000117 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1126211000118 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1126211000119 homodimer interface [polypeptide binding]; other site 1126211000120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211000121 catalytic residue [active] 1126211000122 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1126211000123 thymidylate kinase; Validated; Region: tmk; PRK00698 1126211000124 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1126211000125 TMP-binding site; other site 1126211000126 ATP-binding site [chemical binding]; other site 1126211000127 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1126211000128 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1126211000129 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1126211000130 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1126211000131 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1126211000132 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1126211000133 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1126211000134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211000135 S-adenosylmethionine binding site [chemical binding]; other site 1126211000136 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1126211000137 putative active site [active] 1126211000138 GIY-YIG motif/motif A; other site 1126211000139 putative metal binding site [ion binding]; other site 1126211000140 Predicted methyltransferases [General function prediction only]; Region: COG0313 1126211000141 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1126211000142 putative SAM binding site [chemical binding]; other site 1126211000143 putative homodimer interface [polypeptide binding]; other site 1126211000144 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1126211000145 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1126211000146 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1126211000147 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1126211000148 active site 1126211000149 HIGH motif; other site 1126211000150 KMSKS motif; other site 1126211000151 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1126211000152 tRNA binding surface [nucleotide binding]; other site 1126211000153 anticodon binding site; other site 1126211000154 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1126211000155 dimer interface [polypeptide binding]; other site 1126211000156 putative tRNA-binding site [nucleotide binding]; other site 1126211000157 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1126211000158 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1126211000159 active site 1126211000160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1126211000161 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1126211000162 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1126211000163 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1126211000164 G5 domain; Region: G5; pfam07501 1126211000165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1126211000166 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1126211000167 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1126211000168 putative active site [active] 1126211000169 putative metal binding site [ion binding]; other site 1126211000170 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1126211000171 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1126211000172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211000173 S-adenosylmethionine binding site [chemical binding]; other site 1126211000174 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 1126211000175 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1126211000176 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1126211000177 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1126211000178 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1126211000179 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1126211000180 pur operon repressor; Provisional; Region: PRK09213 1126211000181 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1126211000182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1126211000183 active site 1126211000184 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1126211000185 homotrimer interaction site [polypeptide binding]; other site 1126211000186 putative active site [active] 1126211000187 regulatory protein SpoVG; Reviewed; Region: PRK13259 1126211000188 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1126211000189 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1126211000190 Substrate binding site; other site 1126211000191 Mg++ binding site; other site 1126211000192 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1126211000193 active site 1126211000194 substrate binding site [chemical binding]; other site 1126211000195 CoA binding site [chemical binding]; other site 1126211000196 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1126211000197 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1126211000198 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1126211000199 active site 1126211000200 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1126211000201 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1126211000202 5S rRNA interface [nucleotide binding]; other site 1126211000203 CTC domain interface [polypeptide binding]; other site 1126211000204 L16 interface [polypeptide binding]; other site 1126211000205 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1126211000206 putative active site [active] 1126211000207 catalytic residue [active] 1126211000208 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1126211000209 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1126211000210 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1126211000211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1126211000212 ATP binding site [chemical binding]; other site 1126211000213 putative Mg++ binding site [ion binding]; other site 1126211000214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211000215 nucleotide binding region [chemical binding]; other site 1126211000216 ATP-binding site [chemical binding]; other site 1126211000217 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1126211000218 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1126211000219 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1126211000220 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1126211000221 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1126211000222 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1126211000223 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1126211000224 putative SAM binding site [chemical binding]; other site 1126211000225 putative homodimer interface [polypeptide binding]; other site 1126211000226 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1126211000227 homodimer interface [polypeptide binding]; other site 1126211000228 metal binding site [ion binding]; metal-binding site 1126211000229 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1126211000230 homodimer interface [polypeptide binding]; other site 1126211000231 active site 1126211000232 putative chemical substrate binding site [chemical binding]; other site 1126211000233 metal binding site [ion binding]; metal-binding site 1126211000234 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1126211000235 RNA binding surface [nucleotide binding]; other site 1126211000236 sporulation protein YabP; Region: spore_yabP; TIGR02892 1126211000237 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1126211000238 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1126211000239 Septum formation initiator; Region: DivIC; pfam04977 1126211000240 hypothetical protein; Provisional; Region: PRK08582 1126211000241 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1126211000242 RNA binding site [nucleotide binding]; other site 1126211000243 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1126211000244 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1126211000245 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1126211000246 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1126211000247 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1126211000248 metal ion-dependent adhesion site (MIDAS); other site 1126211000249 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1126211000250 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1126211000251 active site 1126211000252 ATP binding site [chemical binding]; other site 1126211000253 substrate binding site [chemical binding]; other site 1126211000254 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1126211000255 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1126211000256 Ligand Binding Site [chemical binding]; other site 1126211000257 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1126211000258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1126211000259 active site 1126211000260 FtsH Extracellular; Region: FtsH_ext; pfam06480 1126211000261 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1126211000262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211000263 Walker A motif; other site 1126211000264 ATP binding site [chemical binding]; other site 1126211000265 Walker B motif; other site 1126211000266 arginine finger; other site 1126211000267 Peptidase family M41; Region: Peptidase_M41; pfam01434 1126211000268 pantothenate kinase; Reviewed; Region: PRK13318 1126211000269 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1126211000270 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1126211000271 dimerization interface [polypeptide binding]; other site 1126211000272 domain crossover interface; other site 1126211000273 redox-dependent activation switch; other site 1126211000274 SurA N-terminal domain; Region: SurA_N_3; cl07813 1126211000275 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1126211000276 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1126211000277 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1126211000278 dimer interface [polypeptide binding]; other site 1126211000279 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1126211000280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211000281 catalytic residue [active] 1126211000282 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1126211000283 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1126211000284 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1126211000285 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1126211000286 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1126211000287 glutamine binding [chemical binding]; other site 1126211000288 catalytic triad [active] 1126211000289 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1126211000290 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1126211000291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211000292 catalytic residue [active] 1126211000293 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1126211000294 dihydropteroate synthase; Region: DHPS; TIGR01496 1126211000295 substrate binding pocket [chemical binding]; other site 1126211000296 dimer interface [polypeptide binding]; other site 1126211000297 inhibitor binding site; inhibition site 1126211000298 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1126211000299 homooctamer interface [polypeptide binding]; other site 1126211000300 active site 1126211000301 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1126211000302 catalytic center binding site [active] 1126211000303 ATP binding site [chemical binding]; other site 1126211000304 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1126211000305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211000306 non-specific DNA binding site [nucleotide binding]; other site 1126211000307 salt bridge; other site 1126211000308 sequence-specific DNA binding site [nucleotide binding]; other site 1126211000309 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1126211000310 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1126211000311 FMN binding site [chemical binding]; other site 1126211000312 active site 1126211000313 catalytic residues [active] 1126211000314 substrate binding site [chemical binding]; other site 1126211000315 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1126211000316 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1126211000317 dimer interface [polypeptide binding]; other site 1126211000318 putative anticodon binding site; other site 1126211000319 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1126211000320 motif 1; other site 1126211000321 active site 1126211000322 motif 2; other site 1126211000323 motif 3; other site 1126211000324 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1126211000325 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1126211000326 UvrB/uvrC motif; Region: UVR; pfam02151 1126211000327 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1126211000328 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1126211000329 ADP binding site [chemical binding]; other site 1126211000330 phosphagen binding site; other site 1126211000331 substrate specificity loop; other site 1126211000332 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1126211000333 Clp amino terminal domain; Region: Clp_N; pfam02861 1126211000334 Clp amino terminal domain; Region: Clp_N; pfam02861 1126211000335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211000336 Walker A motif; other site 1126211000337 ATP binding site [chemical binding]; other site 1126211000338 Walker B motif; other site 1126211000339 arginine finger; other site 1126211000340 UvrB/uvrC motif; Region: UVR; pfam02151 1126211000341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211000342 Walker A motif; other site 1126211000343 ATP binding site [chemical binding]; other site 1126211000344 Walker B motif; other site 1126211000345 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1126211000346 DNA repair protein RadA; Provisional; Region: PRK11823 1126211000347 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1126211000348 Walker A motif/ATP binding site; other site 1126211000349 ATP binding site [chemical binding]; other site 1126211000350 Walker B motif; other site 1126211000351 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1126211000352 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1126211000353 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1126211000354 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1126211000355 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1126211000356 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1126211000357 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1126211000358 putative active site [active] 1126211000359 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1126211000360 substrate binding site; other site 1126211000361 dimer interface; other site 1126211000362 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1126211000363 homotrimer interaction site [polypeptide binding]; other site 1126211000364 zinc binding site [ion binding]; other site 1126211000365 CDP-binding sites; other site 1126211000366 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1126211000367 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1126211000368 HIGH motif; other site 1126211000369 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1126211000370 active site 1126211000371 KMSKS motif; other site 1126211000372 serine O-acetyltransferase; Region: cysE; TIGR01172 1126211000373 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1126211000374 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1126211000375 trimer interface [polypeptide binding]; other site 1126211000376 active site 1126211000377 substrate binding site [chemical binding]; other site 1126211000378 CoA binding site [chemical binding]; other site 1126211000379 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1126211000380 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1126211000381 active site 1126211000382 HIGH motif; other site 1126211000383 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1126211000384 KMSKS motif; other site 1126211000385 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1126211000386 tRNA binding surface [nucleotide binding]; other site 1126211000387 anticodon binding site; other site 1126211000388 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1126211000389 active site 1126211000390 metal binding site [ion binding]; metal-binding site 1126211000391 dimerization interface [polypeptide binding]; other site 1126211000392 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1126211000393 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1126211000394 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1126211000395 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1126211000396 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1126211000397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1126211000398 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1126211000399 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1126211000400 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1126211000401 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1126211000402 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1126211000403 putative homodimer interface [polypeptide binding]; other site 1126211000404 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1126211000405 heterodimer interface [polypeptide binding]; other site 1126211000406 homodimer interface [polypeptide binding]; other site 1126211000407 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1126211000408 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1126211000409 L7/L12 interface [polypeptide binding]; other site 1126211000410 23S rRNA interface [nucleotide binding]; other site 1126211000411 L25 interface [polypeptide binding]; other site 1126211000412 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1126211000413 mRNA/rRNA interface [nucleotide binding]; other site 1126211000414 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1126211000415 23S rRNA interface [nucleotide binding]; other site 1126211000416 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1126211000417 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1126211000418 core dimer interface [polypeptide binding]; other site 1126211000419 peripheral dimer interface [polypeptide binding]; other site 1126211000420 L10 interface [polypeptide binding]; other site 1126211000421 L11 interface [polypeptide binding]; other site 1126211000422 putative EF-Tu interaction site [polypeptide binding]; other site 1126211000423 putative EF-G interaction site [polypeptide binding]; other site 1126211000424 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1126211000425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211000426 S-adenosylmethionine binding site [chemical binding]; other site 1126211000427 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1126211000428 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1126211000429 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1126211000430 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1126211000431 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1126211000432 RPB1 interaction site [polypeptide binding]; other site 1126211000433 RPB10 interaction site [polypeptide binding]; other site 1126211000434 RPB11 interaction site [polypeptide binding]; other site 1126211000435 RPB3 interaction site [polypeptide binding]; other site 1126211000436 RPB12 interaction site [polypeptide binding]; other site 1126211000437 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1126211000438 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1126211000439 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1126211000440 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1126211000441 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1126211000442 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1126211000443 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1126211000444 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1126211000445 G-loop; other site 1126211000446 DNA binding site [nucleotide binding] 1126211000447 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1126211000448 30S ribosomal protein S7; Validated; Region: PRK05302 1126211000449 elongation factor G; Reviewed; Region: PRK00007 1126211000450 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1126211000451 Switch I region; other site 1126211000452 G2 box; other site 1126211000453 putative GEF interaction site [polypeptide binding]; other site 1126211000454 G3 box; other site 1126211000455 Switch II region; other site 1126211000456 GTP/Mg2+ binding site [chemical binding]; other site 1126211000457 G4 box; other site 1126211000458 G5 box; other site 1126211000459 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1126211000460 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1126211000461 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1126211000462 elongation factor Tu; Reviewed; Region: PRK00049 1126211000463 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1126211000464 G1 box; other site 1126211000465 GEF interaction site [polypeptide binding]; other site 1126211000466 GTP/Mg2+ binding site [chemical binding]; other site 1126211000467 Switch I region; other site 1126211000468 G2 box; other site 1126211000469 G3 box; other site 1126211000470 Switch II region; other site 1126211000471 G4 box; other site 1126211000472 G5 box; other site 1126211000473 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1126211000474 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1126211000475 Antibiotic Binding Site [chemical binding]; other site 1126211000476 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1126211000477 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1126211000478 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1126211000479 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1126211000480 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1126211000481 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1126211000482 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1126211000483 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1126211000484 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1126211000485 G-X-X-G motif; other site 1126211000486 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1126211000487 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1126211000488 L27 interface [polypeptide binding]; other site 1126211000489 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1126211000490 23S rRNA interface [nucleotide binding]; other site 1126211000491 putative translocon interaction site; other site 1126211000492 signal recognition particle (SRP54) interaction site; other site 1126211000493 L23 interface [polypeptide binding]; other site 1126211000494 trigger factor interaction site; other site 1126211000495 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1126211000496 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1126211000497 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1126211000498 RNA binding site [nucleotide binding]; other site 1126211000499 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1126211000500 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1126211000501 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1126211000502 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1126211000503 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1126211000504 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1126211000505 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1126211000506 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1126211000507 23S rRNA interface [nucleotide binding]; other site 1126211000508 L5 interface [polypeptide binding]; other site 1126211000509 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1126211000510 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1126211000511 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1126211000512 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1126211000513 23S rRNA binding site [nucleotide binding]; other site 1126211000514 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1126211000515 preprotein translocase, SecY subunit; Region: 3a0501s007; TIGR00967 1126211000516 SecY translocase; Region: SecY; pfam00344 1126211000517 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1126211000518 active site 1126211000519 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1126211000520 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1126211000521 alphaNTD - beta' interaction site [polypeptide binding]; other site 1126211000522 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1126211000523 alphaNTD - beta interaction site [polypeptide binding]; other site 1126211000524 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1126211000525 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1126211000526 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1126211000527 Walker A/P-loop; other site 1126211000528 ATP binding site [chemical binding]; other site 1126211000529 Q-loop/lid; other site 1126211000530 ABC transporter signature motif; other site 1126211000531 Walker B; other site 1126211000532 D-loop; other site 1126211000533 H-loop/switch region; other site 1126211000534 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1126211000535 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1126211000536 Walker A/P-loop; other site 1126211000537 ATP binding site [chemical binding]; other site 1126211000538 Q-loop/lid; other site 1126211000539 ABC transporter signature motif; other site 1126211000540 Walker B; other site 1126211000541 D-loop; other site 1126211000542 H-loop/switch region; other site 1126211000543 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1126211000544 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1126211000545 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1126211000546 dimerization interface 3.5A [polypeptide binding]; other site 1126211000547 active site 1126211000548 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1126211000549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211000550 S-adenosylmethionine binding site [chemical binding]; other site 1126211000551 DinB family; Region: DinB; cl17821 1126211000552 DinB superfamily; Region: DinB_2; pfam12867 1126211000553 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1126211000554 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1126211000555 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1126211000556 active site 1126211000557 metal binding site [ion binding]; metal-binding site 1126211000558 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1126211000559 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1126211000560 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1126211000561 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1126211000562 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1126211000563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211000564 putative substrate translocation pore; other site 1126211000565 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1126211000566 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1126211000567 inhibitor-cofactor binding pocket; inhibition site 1126211000568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211000569 catalytic residue [active] 1126211000570 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1126211000571 active site 1126211000572 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1126211000573 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1126211000574 NAD(P) binding site [chemical binding]; other site 1126211000575 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1126211000576 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1126211000577 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1126211000578 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1126211000579 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1126211000580 Sodium Bile acid symporter family; Region: SBF; cl17470 1126211000581 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1126211000582 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1126211000583 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1126211000584 ABC-ATPase subunit interface; other site 1126211000585 dimer interface [polypeptide binding]; other site 1126211000586 putative PBP binding regions; other site 1126211000587 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1126211000588 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1126211000589 ABC-ATPase subunit interface; other site 1126211000590 dimer interface [polypeptide binding]; other site 1126211000591 putative PBP binding regions; other site 1126211000592 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1126211000593 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1126211000594 intersubunit interface [polypeptide binding]; other site 1126211000595 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1126211000596 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1126211000597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1126211000598 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1126211000599 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1126211000600 intersubunit interface [polypeptide binding]; other site 1126211000601 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 1126211000602 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1126211000603 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1126211000604 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1126211000605 putative periplasmic esterase; Provisional; Region: PRK03642 1126211000606 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1126211000607 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1126211000608 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1126211000609 active site turn [active] 1126211000610 phosphorylation site [posttranslational modification] 1126211000611 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1126211000612 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1126211000613 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1126211000614 putative active site [active] 1126211000615 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1126211000616 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1126211000617 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1126211000618 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1126211000619 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1126211000620 DNA binding residues [nucleotide binding] 1126211000621 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1126211000622 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1126211000623 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1126211000624 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1126211000625 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1126211000626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1126211000627 YbbR-like protein; Region: YbbR; pfam07949 1126211000628 YbbR-like protein; Region: YbbR; pfam07949 1126211000629 YbbR-like protein; Region: YbbR; pfam07949 1126211000630 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1126211000631 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1126211000632 active site 1126211000633 substrate binding site [chemical binding]; other site 1126211000634 metal binding site [ion binding]; metal-binding site 1126211000635 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1126211000636 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1126211000637 glutaminase active site [active] 1126211000638 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1126211000639 dimer interface [polypeptide binding]; other site 1126211000640 active site 1126211000641 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1126211000642 dimer interface [polypeptide binding]; other site 1126211000643 active site 1126211000644 SIR2-like domain; Region: SIR2_2; pfam13289 1126211000645 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1126211000646 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1126211000647 Walker A/P-loop; other site 1126211000648 ATP binding site [chemical binding]; other site 1126211000649 Q-loop/lid; other site 1126211000650 ABC transporter signature motif; other site 1126211000651 Walker B; other site 1126211000652 D-loop; other site 1126211000653 H-loop/switch region; other site 1126211000654 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1126211000655 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1126211000656 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1126211000657 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1126211000658 active site 1126211000659 catalytic tetrad [active] 1126211000660 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1126211000661 LrgA family; Region: LrgA; cl00608 1126211000662 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211000663 MarR family; Region: MarR; pfam01047 1126211000664 putative transport protein YifK; Provisional; Region: PRK10746 1126211000665 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1126211000666 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211000667 active site 1126211000668 motif I; other site 1126211000669 motif II; other site 1126211000670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1126211000671 Histidine kinase; Region: HisKA_3; pfam07730 1126211000672 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1126211000673 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1126211000674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211000675 active site 1126211000676 phosphorylation site [posttranslational modification] 1126211000677 intermolecular recognition site; other site 1126211000678 dimerization interface [polypeptide binding]; other site 1126211000679 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1126211000680 DNA binding residues [nucleotide binding] 1126211000681 dimerization interface [polypeptide binding]; other site 1126211000682 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1126211000683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211000684 Walker A/P-loop; other site 1126211000685 ATP binding site [chemical binding]; other site 1126211000686 Q-loop/lid; other site 1126211000687 ABC transporter signature motif; other site 1126211000688 Walker B; other site 1126211000689 D-loop; other site 1126211000690 H-loop/switch region; other site 1126211000691 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1126211000692 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1126211000693 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1126211000694 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1126211000695 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1126211000696 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1126211000697 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1126211000698 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1126211000699 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1126211000700 active site 1126211000701 catalytic site [active] 1126211000702 metal binding site [ion binding]; metal-binding site 1126211000703 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1126211000704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211000705 putative substrate translocation pore; other site 1126211000706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211000707 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1126211000708 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1126211000709 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1126211000710 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1126211000711 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1126211000712 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1126211000713 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1126211000714 active site 1126211000715 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211000716 non-specific DNA binding site [nucleotide binding]; other site 1126211000717 salt bridge; other site 1126211000718 sequence-specific DNA binding site [nucleotide binding]; other site 1126211000719 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1126211000720 Glycerol_dehydrogenase-like; Region: GlyDH-like; cd08550 1126211000721 active site 1126211000722 NAD binding site [chemical binding]; other site 1126211000723 metal binding site [ion binding]; metal-binding site 1126211000724 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1126211000725 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1126211000726 ATP-grasp domain; Region: ATP-grasp; pfam02222 1126211000727 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1126211000728 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1126211000729 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1126211000730 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1126211000731 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1126211000732 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1126211000733 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1126211000734 active site residue [active] 1126211000735 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1126211000736 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1126211000737 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1126211000738 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1126211000739 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1126211000740 homodimer interface [polypeptide binding]; other site 1126211000741 substrate-cofactor binding pocket; other site 1126211000742 catalytic residue [active] 1126211000743 S-methylmethionine transporter; Provisional; Region: PRK11387 1126211000744 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1126211000745 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1126211000746 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1126211000747 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1126211000748 glutaminase; Reviewed; Region: PRK12357 1126211000749 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1126211000750 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211000751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211000752 ATP binding site [chemical binding]; other site 1126211000753 Mg2+ binding site [ion binding]; other site 1126211000754 G-X-G motif; other site 1126211000755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211000756 Response regulator receiver domain; Region: Response_reg; pfam00072 1126211000757 active site 1126211000758 phosphorylation site [posttranslational modification] 1126211000759 intermolecular recognition site; other site 1126211000760 dimerization interface [polypeptide binding]; other site 1126211000761 YcbB domain; Region: YcbB; pfam08664 1126211000762 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1126211000763 putative active site [active] 1126211000764 putative substrate binding site [chemical binding]; other site 1126211000765 Phosphotransferase enzyme family; Region: APH; pfam01636 1126211000766 ATP binding site [chemical binding]; other site 1126211000767 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1126211000768 dodecamer interface 1 [polypeptide binding]; other site 1126211000769 dodecamer interface 2 [polypeptide binding]; other site 1126211000770 trimer interface [polypeptide binding]; other site 1126211000771 TRAP binding interface [polypeptide binding]; other site 1126211000772 Zn binding site [ion binding]; other site 1126211000773 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1126211000774 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1126211000775 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1126211000776 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1126211000777 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1126211000778 putative active site [active] 1126211000779 putative metal binding site [ion binding]; other site 1126211000780 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1126211000781 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1126211000782 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1126211000783 putative substrate binding pocket [chemical binding]; other site 1126211000784 AC domain interface; other site 1126211000785 catalytic triad [active] 1126211000786 AB domain interface; other site 1126211000787 interchain disulfide; other site 1126211000788 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1126211000789 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1126211000790 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1126211000791 catalytic residue [active] 1126211000792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211000793 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211000794 putative substrate translocation pore; other site 1126211000795 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211000796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211000797 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1126211000798 active site 1126211000799 homotetramer interface [polypeptide binding]; other site 1126211000800 homodimer interface [polypeptide binding]; other site 1126211000801 Lipase (class 2); Region: Lipase_2; pfam01674 1126211000802 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1126211000803 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1126211000804 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1126211000805 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1126211000806 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1126211000807 active site 1126211000808 catalytic tetrad [active] 1126211000809 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1126211000810 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1126211000811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211000812 binding surface 1126211000813 TPR motif; other site 1126211000814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1126211000815 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211000816 TPR motif; other site 1126211000817 binding surface 1126211000818 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1126211000819 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1126211000820 NAD binding site [chemical binding]; other site 1126211000821 homodimer interface [polypeptide binding]; other site 1126211000822 active site 1126211000823 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1126211000824 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1126211000825 Ca binding site [ion binding]; other site 1126211000826 active site 1126211000827 catalytic site [active] 1126211000828 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1126211000829 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1126211000830 metal binding site [ion binding]; metal-binding site 1126211000831 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1126211000832 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1126211000833 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1126211000834 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1126211000835 ABC-ATPase subunit interface; other site 1126211000836 dimer interface [polypeptide binding]; other site 1126211000837 putative PBP binding regions; other site 1126211000838 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1126211000839 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1126211000840 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1126211000841 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1126211000842 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1126211000843 putative metal binding site [ion binding]; other site 1126211000844 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1126211000845 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1126211000846 putative metal binding site [ion binding]; other site 1126211000847 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1126211000848 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1126211000849 putative metal binding site [ion binding]; other site 1126211000850 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1126211000851 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1126211000852 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1126211000853 benzoate transport; Region: 2A0115; TIGR00895 1126211000854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211000855 putative substrate translocation pore; other site 1126211000856 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1126211000857 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1126211000858 Walker A/P-loop; other site 1126211000859 ATP binding site [chemical binding]; other site 1126211000860 Q-loop/lid; other site 1126211000861 ABC transporter signature motif; other site 1126211000862 Walker B; other site 1126211000863 D-loop; other site 1126211000864 H-loop/switch region; other site 1126211000865 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1126211000866 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1126211000867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211000868 dimer interface [polypeptide binding]; other site 1126211000869 conserved gate region; other site 1126211000870 putative PBP binding loops; other site 1126211000871 ABC-ATPase subunit interface; other site 1126211000872 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1126211000873 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1126211000874 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1126211000875 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1126211000876 amidohydrolase; Region: amidohydrolases; TIGR01891 1126211000877 metal binding site [ion binding]; metal-binding site 1126211000878 putative dimer interface [polypeptide binding]; other site 1126211000879 Predicted membrane protein [Function unknown]; Region: COG1288 1126211000880 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1126211000881 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1126211000882 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1126211000883 active site 1126211000884 Ca binding site [ion binding]; other site 1126211000885 catalytic site [active] 1126211000886 Aamy_C domain; Region: Aamy_C; smart00632 1126211000887 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1126211000888 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1126211000889 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1126211000890 NAD binding site [chemical binding]; other site 1126211000891 dimer interface [polypeptide binding]; other site 1126211000892 substrate binding site [chemical binding]; other site 1126211000893 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1126211000894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211000895 putative substrate translocation pore; other site 1126211000896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211000897 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211000898 MarR family; Region: MarR; pfam01047 1126211000899 LysE type translocator; Region: LysE; pfam01810 1126211000900 Uncharacterized conserved protein [Function unknown]; Region: COG3403 1126211000901 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1126211000902 Spore germination protein; Region: Spore_permease; cl17796 1126211000903 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1126211000904 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1126211000905 NAD+ synthetase; Region: nadE; TIGR00552 1126211000906 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1126211000907 homodimer interface [polypeptide binding]; other site 1126211000908 NAD binding pocket [chemical binding]; other site 1126211000909 ATP binding pocket [chemical binding]; other site 1126211000910 Mg binding site [ion binding]; other site 1126211000911 active-site loop [active] 1126211000912 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 1126211000913 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1126211000914 AAA domain; Region: AAA_18; pfam13238 1126211000915 active site 1126211000916 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1126211000917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211000918 D-galactonate transporter; Region: 2A0114; TIGR00893 1126211000919 putative substrate translocation pore; other site 1126211000920 shikimate kinase; Reviewed; Region: aroK; PRK00131 1126211000921 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1126211000922 ADP binding site [chemical binding]; other site 1126211000923 magnesium binding site [ion binding]; other site 1126211000924 putative shikimate binding site; other site 1126211000925 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1126211000926 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1126211000927 Proline dehydrogenase; Region: Pro_dh; pfam01619 1126211000928 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1126211000929 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1126211000930 Glutamate binding site [chemical binding]; other site 1126211000931 homodimer interface [polypeptide binding]; other site 1126211000932 NAD binding site [chemical binding]; other site 1126211000933 catalytic residues [active] 1126211000934 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1126211000935 Na binding site [ion binding]; other site 1126211000936 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1126211000937 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1126211000938 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1126211000939 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1126211000940 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1126211000941 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 1126211000942 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1126211000943 active site 1126211000944 SAM binding site [chemical binding]; other site 1126211000945 homodimer interface [polypeptide binding]; other site 1126211000946 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1126211000947 [2Fe-2S] cluster binding site [ion binding]; other site 1126211000948 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1126211000949 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1126211000950 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1126211000951 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1126211000952 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1126211000953 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1126211000954 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1126211000955 [4Fe-4S] binding site [ion binding]; other site 1126211000956 molybdopterin cofactor binding site; other site 1126211000957 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1126211000958 molybdopterin cofactor binding site; other site 1126211000959 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1126211000960 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1126211000961 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1126211000962 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1126211000963 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1126211000964 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1126211000965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211000966 putative substrate translocation pore; other site 1126211000967 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1126211000968 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1126211000969 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1126211000970 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1126211000971 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1126211000972 NAD binding site [chemical binding]; other site 1126211000973 catalytic Zn binding site [ion binding]; other site 1126211000974 structural Zn binding site [ion binding]; other site 1126211000975 RDD family; Region: RDD; pfam06271 1126211000976 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1126211000977 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1126211000978 beta-galactosidase; Region: BGL; TIGR03356 1126211000979 Competence protein J (ComJ); Region: ComJ; pfam11033 1126211000980 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1126211000981 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1126211000982 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1126211000983 tetramer interface [polypeptide binding]; other site 1126211000984 active site 1126211000985 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1126211000986 active site 1126211000987 dimer interface [polypeptide binding]; other site 1126211000988 magnesium binding site [ion binding]; other site 1126211000989 Predicted transcriptional regulators [Transcription]; Region: COG1733 1126211000990 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1126211000991 Condensation domain; Region: Condensation; pfam00668 1126211000992 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211000993 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211000994 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211000995 acyl-activating enzyme (AAE) consensus motif; other site 1126211000996 AMP binding site [chemical binding]; other site 1126211000997 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211000998 Condensation domain; Region: Condensation; pfam00668 1126211000999 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211001000 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211001001 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1126211001002 acyl-activating enzyme (AAE) consensus motif; other site 1126211001003 AMP binding site [chemical binding]; other site 1126211001004 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211001005 Condensation domain; Region: Condensation; pfam00668 1126211001006 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211001007 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211001008 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211001009 acyl-activating enzyme (AAE) consensus motif; other site 1126211001010 AMP binding site [chemical binding]; other site 1126211001011 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211001012 Condensation domain; Region: Condensation; pfam00668 1126211001013 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211001014 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1126211001015 Condensation domain; Region: Condensation; pfam00668 1126211001016 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211001017 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1126211001018 acyl-activating enzyme (AAE) consensus motif; other site 1126211001019 AMP binding site [chemical binding]; other site 1126211001020 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211001021 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1126211001022 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1126211001023 PGAP1-like protein; Region: PGAP1; pfam07819 1126211001024 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1126211001025 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211001026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211001027 homodimer interface [polypeptide binding]; other site 1126211001028 catalytic residue [active] 1126211001029 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1126211001030 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 1126211001031 Predicted membrane protein [Function unknown]; Region: COG2364 1126211001032 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1126211001033 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1126211001034 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1126211001035 Walker A/P-loop; other site 1126211001036 ATP binding site [chemical binding]; other site 1126211001037 Q-loop/lid; other site 1126211001038 ABC transporter signature motif; other site 1126211001039 Walker B; other site 1126211001040 D-loop; other site 1126211001041 H-loop/switch region; other site 1126211001042 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1126211001043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211001044 dimer interface [polypeptide binding]; other site 1126211001045 conserved gate region; other site 1126211001046 putative PBP binding loops; other site 1126211001047 ABC-ATPase subunit interface; other site 1126211001048 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1126211001049 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1126211001050 substrate binding pocket [chemical binding]; other site 1126211001051 membrane-bound complex binding site; other site 1126211001052 hinge residues; other site 1126211001053 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1126211001054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1126211001055 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1126211001056 dimerization interface [polypeptide binding]; other site 1126211001057 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1126211001058 Flavoprotein; Region: Flavoprotein; pfam02441 1126211001059 UbiD family decarboxylase; Region: TIGR00148 1126211001060 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1126211001061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211001062 putative substrate translocation pore; other site 1126211001063 POT family; Region: PTR2; pfam00854 1126211001064 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1126211001065 Right handed beta helix region; Region: Beta_helix; pfam13229 1126211001066 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1126211001067 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1126211001068 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1126211001069 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1126211001070 Spore germination protein; Region: Spore_permease; pfam03845 1126211001071 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1126211001072 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1126211001073 active site 1126211001074 non-prolyl cis peptide bond; other site 1126211001075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211001076 Coenzyme A binding pocket [chemical binding]; other site 1126211001077 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1126211001078 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1126211001079 substrate binding pocket [chemical binding]; other site 1126211001080 membrane-bound complex binding site; other site 1126211001081 hinge residues; other site 1126211001082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211001083 dimer interface [polypeptide binding]; other site 1126211001084 conserved gate region; other site 1126211001085 putative PBP binding loops; other site 1126211001086 ABC-ATPase subunit interface; other site 1126211001087 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1126211001088 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1126211001089 Walker A/P-loop; other site 1126211001090 ATP binding site [chemical binding]; other site 1126211001091 Q-loop/lid; other site 1126211001092 ABC transporter signature motif; other site 1126211001093 Walker B; other site 1126211001094 D-loop; other site 1126211001095 H-loop/switch region; other site 1126211001096 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1126211001097 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1126211001098 metal binding site [ion binding]; metal-binding site 1126211001099 dimer interface [polypeptide binding]; other site 1126211001100 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1126211001101 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1126211001102 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1126211001103 Walker A/P-loop; other site 1126211001104 ATP binding site [chemical binding]; other site 1126211001105 Q-loop/lid; other site 1126211001106 ABC transporter signature motif; other site 1126211001107 Walker B; other site 1126211001108 D-loop; other site 1126211001109 H-loop/switch region; other site 1126211001110 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1126211001111 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1126211001112 FtsX-like permease family; Region: FtsX; pfam02687 1126211001113 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211001114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211001115 active site 1126211001116 phosphorylation site [posttranslational modification] 1126211001117 intermolecular recognition site; other site 1126211001118 dimerization interface [polypeptide binding]; other site 1126211001119 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211001120 DNA binding site [nucleotide binding] 1126211001121 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211001122 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1126211001123 dimerization interface [polypeptide binding]; other site 1126211001124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211001125 dimer interface [polypeptide binding]; other site 1126211001126 phosphorylation site [posttranslational modification] 1126211001127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211001128 ATP binding site [chemical binding]; other site 1126211001129 Mg2+ binding site [ion binding]; other site 1126211001130 G-X-G motif; other site 1126211001131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1126211001132 binding surface 1126211001133 TPR motif; other site 1126211001134 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211001135 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211001136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211001137 TPR motif; other site 1126211001138 binding surface 1126211001139 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211001140 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1126211001141 aspartate kinase; Reviewed; Region: PRK09034 1126211001142 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1126211001143 putative catalytic residues [active] 1126211001144 putative nucleotide binding site [chemical binding]; other site 1126211001145 putative aspartate binding site [chemical binding]; other site 1126211001146 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1126211001147 allosteric regulatory residue; other site 1126211001148 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1126211001149 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1126211001150 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1126211001151 ABC-ATPase subunit interface; other site 1126211001152 dimer interface [polypeptide binding]; other site 1126211001153 putative PBP binding regions; other site 1126211001154 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1126211001155 ABC-ATPase subunit interface; other site 1126211001156 dimer interface [polypeptide binding]; other site 1126211001157 putative PBP binding regions; other site 1126211001158 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1126211001159 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1126211001160 Walker A/P-loop; other site 1126211001161 ATP binding site [chemical binding]; other site 1126211001162 Q-loop/lid; other site 1126211001163 ABC transporter signature motif; other site 1126211001164 Walker B; other site 1126211001165 D-loop; other site 1126211001166 H-loop/switch region; other site 1126211001167 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1126211001168 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1126211001169 putative ligand binding residues [chemical binding]; other site 1126211001170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211001171 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211001172 putative substrate translocation pore; other site 1126211001173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211001174 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211001175 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211001176 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1126211001177 dimer interface [polypeptide binding]; other site 1126211001178 FMN binding site [chemical binding]; other site 1126211001179 NADPH bind site [chemical binding]; other site 1126211001180 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1126211001181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1126211001182 dimerization interface [polypeptide binding]; other site 1126211001183 putative DNA binding site [nucleotide binding]; other site 1126211001184 putative Zn2+ binding site [ion binding]; other site 1126211001185 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1126211001186 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211001187 DNA-binding site [nucleotide binding]; DNA binding site 1126211001188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211001189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211001190 homodimer interface [polypeptide binding]; other site 1126211001191 catalytic residue [active] 1126211001192 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1126211001193 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1126211001194 inhibitor-cofactor binding pocket; inhibition site 1126211001195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211001196 catalytic residue [active] 1126211001197 succinic semialdehyde dehydrogenase; Region: PLN02278 1126211001198 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1126211001199 tetramerization interface [polypeptide binding]; other site 1126211001200 NAD(P) binding site [chemical binding]; other site 1126211001201 catalytic residues [active] 1126211001202 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1126211001203 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1126211001204 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1126211001205 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1126211001206 NAD binding site [chemical binding]; other site 1126211001207 homodimer interface [polypeptide binding]; other site 1126211001208 active site 1126211001209 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1126211001210 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1126211001211 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1126211001212 YtkA-like; Region: YtkA; pfam13115 1126211001213 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1126211001214 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1126211001215 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1126211001216 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1126211001217 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1126211001218 active site 1126211001219 P-loop; other site 1126211001220 phosphorylation site [posttranslational modification] 1126211001221 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1126211001222 active site 1126211001223 phosphorylation site [posttranslational modification] 1126211001224 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1126211001225 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1126211001226 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1126211001227 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1126211001228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211001229 active site 1126211001230 motif I; other site 1126211001231 motif II; other site 1126211001232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211001233 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1126211001234 putative active site [active] 1126211001235 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1126211001236 hypothetical protein; Provisional; Region: PRK05463 1126211001237 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1126211001238 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1126211001239 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1126211001240 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1126211001241 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1126211001242 Bacterial transcriptional regulator; Region: IclR; pfam01614 1126211001243 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1126211001244 active site 1126211001245 catalytic triad [active] 1126211001246 oxyanion hole [active] 1126211001247 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1126211001248 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1126211001249 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1126211001250 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1126211001251 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1126211001252 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1126211001253 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1126211001254 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1126211001255 active site 1126211001256 catalytic tetrad [active] 1126211001257 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1126211001258 HTH domain; Region: HTH_11; pfam08279 1126211001259 Mga helix-turn-helix domain; Region: Mga; pfam05043 1126211001260 PRD domain; Region: PRD; pfam00874 1126211001261 PRD domain; Region: PRD; pfam00874 1126211001262 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1126211001263 active site 1126211001264 P-loop; other site 1126211001265 phosphorylation site [posttranslational modification] 1126211001266 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1126211001267 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1126211001268 acyl-activating enzyme (AAE) consensus motif; other site 1126211001269 putative AMP binding site [chemical binding]; other site 1126211001270 putative active site [active] 1126211001271 putative CoA binding site [chemical binding]; other site 1126211001272 short chain dehydrogenase; Provisional; Region: PRK06701 1126211001273 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1126211001274 NAD binding site [chemical binding]; other site 1126211001275 metal binding site [ion binding]; metal-binding site 1126211001276 active site 1126211001277 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1126211001278 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1126211001279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1126211001280 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1126211001281 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1126211001282 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1126211001283 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1126211001284 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1126211001285 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1126211001286 putative DNA binding site [nucleotide binding]; other site 1126211001287 putative Zn2+ binding site [ion binding]; other site 1126211001288 AsnC family; Region: AsnC_trans_reg; pfam01037 1126211001289 DNA topoisomerase III; Provisional; Region: PRK07726 1126211001290 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1126211001291 active site 1126211001292 putative interdomain interaction site [polypeptide binding]; other site 1126211001293 putative metal-binding site [ion binding]; other site 1126211001294 putative nucleotide binding site [chemical binding]; other site 1126211001295 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1126211001296 domain I; other site 1126211001297 DNA binding groove [nucleotide binding] 1126211001298 phosphate binding site [ion binding]; other site 1126211001299 domain II; other site 1126211001300 domain III; other site 1126211001301 nucleotide binding site [chemical binding]; other site 1126211001302 catalytic site [active] 1126211001303 domain IV; other site 1126211001304 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1126211001305 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1126211001306 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1126211001307 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1126211001308 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1126211001309 metal binding site [ion binding]; metal-binding site 1126211001310 active site 1126211001311 I-site; other site 1126211001312 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1126211001313 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1126211001314 NodB motif; other site 1126211001315 putative active site [active] 1126211001316 putative catalytic site [active] 1126211001317 putative Zn binding site [ion binding]; other site 1126211001318 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1126211001319 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1126211001320 DXD motif; other site 1126211001321 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1126211001322 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1126211001323 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1126211001324 nudix motif; other site 1126211001325 pyruvate oxidase; Provisional; Region: PRK08611 1126211001326 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1126211001327 PYR/PP interface [polypeptide binding]; other site 1126211001328 dimer interface [polypeptide binding]; other site 1126211001329 tetramer interface [polypeptide binding]; other site 1126211001330 TPP binding site [chemical binding]; other site 1126211001331 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1126211001332 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1126211001333 TPP-binding site [chemical binding]; other site 1126211001334 manganese transport protein MntH; Reviewed; Region: PRK00701 1126211001335 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1126211001336 Bacterial SH3 domain; Region: SH3_3; cl17532 1126211001337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1126211001338 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1126211001339 EcsC protein family; Region: EcsC; pfam12787 1126211001340 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1126211001341 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1126211001342 dimanganese center [ion binding]; other site 1126211001343 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1126211001344 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1126211001345 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1126211001346 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1126211001347 putative active site [active] 1126211001348 heme pocket [chemical binding]; other site 1126211001349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211001350 ATP binding site [chemical binding]; other site 1126211001351 Mg2+ binding site [ion binding]; other site 1126211001352 G-X-G motif; other site 1126211001353 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1126211001354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211001355 active site 1126211001356 phosphorylation site [posttranslational modification] 1126211001357 intermolecular recognition site; other site 1126211001358 dimerization interface [polypeptide binding]; other site 1126211001359 HTH domain; Region: HTH_11; pfam08279 1126211001360 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1126211001361 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1126211001362 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1126211001363 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1126211001364 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1126211001365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211001366 Walker A/P-loop; other site 1126211001367 ATP binding site [chemical binding]; other site 1126211001368 Q-loop/lid; other site 1126211001369 ABC transporter signature motif; other site 1126211001370 Walker B; other site 1126211001371 D-loop; other site 1126211001372 H-loop/switch region; other site 1126211001373 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1126211001374 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1126211001375 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1126211001376 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1126211001377 active site 1126211001378 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1126211001379 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1126211001380 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1126211001381 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1126211001382 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1126211001383 catalytic residues [active] 1126211001384 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1126211001385 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1126211001386 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1126211001387 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1126211001388 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1126211001389 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1126211001390 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1126211001391 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1126211001392 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1126211001393 ATP binding site [chemical binding]; other site 1126211001394 Mg++ binding site [ion binding]; other site 1126211001395 motif III; other site 1126211001396 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211001397 nucleotide binding region [chemical binding]; other site 1126211001398 ATP-binding site [chemical binding]; other site 1126211001399 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1126211001400 Predicted membrane protein [Function unknown]; Region: COG3428 1126211001401 Bacterial PH domain; Region: DUF304; pfam03703 1126211001402 Bacterial PH domain; Region: DUF304; pfam03703 1126211001403 Bacterial PH domain; Region: DUF304; pfam03703 1126211001404 Rhomboid family; Region: Rhomboid; pfam01694 1126211001405 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1126211001406 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1126211001407 alanine racemase; Region: alr; TIGR00492 1126211001408 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1126211001409 active site 1126211001410 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1126211001411 dimer interface [polypeptide binding]; other site 1126211001412 substrate binding site [chemical binding]; other site 1126211001413 catalytic residues [active] 1126211001414 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1126211001415 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1126211001416 Rsbr N terminal; Region: Rsbr_N; pfam08678 1126211001417 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1126211001418 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1126211001419 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1126211001420 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1126211001421 CoA binding domain; Region: CoA_binding; cl17356 1126211001422 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1126211001423 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1126211001424 anti sigma factor interaction site; other site 1126211001425 regulatory phosphorylation site [posttranslational modification]; other site 1126211001426 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1126211001427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211001428 ATP binding site [chemical binding]; other site 1126211001429 Mg2+ binding site [ion binding]; other site 1126211001430 G-X-G motif; other site 1126211001431 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1126211001432 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1126211001433 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1126211001434 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1126211001435 DNA binding residues [nucleotide binding] 1126211001436 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1126211001437 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1126211001438 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1126211001439 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1126211001440 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1126211001441 RNA binding site [nucleotide binding]; other site 1126211001442 SprT homologues; Region: SprT; cl01182 1126211001443 hypothetical protein; Provisional; Region: PRK04351 1126211001444 proline/glycine betaine transporter; Provisional; Region: PRK10642 1126211001445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211001446 putative substrate translocation pore; other site 1126211001447 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1126211001448 putative active site [active] 1126211001449 putative catalytic site [active] 1126211001450 Protein of unknown function (DUF419); Region: DUF419; cl15265 1126211001451 Predicted transcriptional regulator [Transcription]; Region: COG1959 1126211001452 Transcriptional regulator; Region: Rrf2; pfam02082 1126211001453 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1126211001454 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1126211001455 NAD binding site [chemical binding]; other site 1126211001456 substrate binding site [chemical binding]; other site 1126211001457 putative active site [active] 1126211001458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211001459 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211001460 putative substrate translocation pore; other site 1126211001461 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211001462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211001463 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1126211001464 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1126211001465 putative di-iron ligands [ion binding]; other site 1126211001466 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1126211001467 DNA-binding site [nucleotide binding]; DNA binding site 1126211001468 RNA-binding motif; other site 1126211001469 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1126211001470 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1126211001471 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1126211001472 active site residue [active] 1126211001473 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1126211001474 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1126211001475 active site residue [active] 1126211001476 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1126211001477 active site residue [active] 1126211001478 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1126211001479 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1126211001480 CPxP motif; other site 1126211001481 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1126211001482 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1126211001483 aspartate racemase; Region: asp_race; TIGR00035 1126211001484 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1126211001485 Predicted transcriptional regulators [Transcription]; Region: COG1695 1126211001486 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1126211001487 Patatin [General function prediction only]; Region: COG3621 1126211001488 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 1126211001489 active site 1126211001490 nucleophile elbow; other site 1126211001491 DinB family; Region: DinB; cl17821 1126211001492 DinB superfamily; Region: DinB_2; pfam12867 1126211001493 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1126211001494 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1126211001495 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1126211001496 catalytic residue [active] 1126211001497 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1126211001498 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211001499 DNA-binding site [nucleotide binding]; DNA binding site 1126211001500 FCD domain; Region: FCD; pfam07729 1126211001501 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1126211001502 homotrimer interaction site [polypeptide binding]; other site 1126211001503 putative active site [active] 1126211001504 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1126211001505 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1126211001506 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1126211001507 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1126211001508 metal binding site [ion binding]; metal-binding site 1126211001509 putative dimer interface [polypeptide binding]; other site 1126211001510 Cupin domain; Region: Cupin_2; pfam07883 1126211001511 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1126211001512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1126211001513 allantoate amidohydrolase; Reviewed; Region: PRK12890 1126211001514 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1126211001515 active site 1126211001516 metal binding site [ion binding]; metal-binding site 1126211001517 dimer interface [polypeptide binding]; other site 1126211001518 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1126211001519 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211001520 DNA-binding site [nucleotide binding]; DNA binding site 1126211001521 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211001522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211001523 homodimer interface [polypeptide binding]; other site 1126211001524 catalytic residue [active] 1126211001525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211001526 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211001527 putative substrate translocation pore; other site 1126211001528 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1126211001529 nudix motif; other site 1126211001530 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1126211001531 FAD binding domain; Region: FAD_binding_4; pfam01565 1126211001532 Berberine and berberine like; Region: BBE; pfam08031 1126211001533 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1126211001534 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1126211001535 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1126211001536 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1126211001537 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1126211001538 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1126211001539 DinB superfamily; Region: DinB_2; pfam12867 1126211001540 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1126211001541 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1126211001542 inhibitor site; inhibition site 1126211001543 active site 1126211001544 dimer interface [polypeptide binding]; other site 1126211001545 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 1126211001546 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 1126211001547 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1126211001548 dimerization interface [polypeptide binding]; other site 1126211001549 active site 1126211001550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211001551 S-adenosylmethionine binding site [chemical binding]; other site 1126211001552 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1126211001553 dimer interface [polypeptide binding]; other site 1126211001554 substrate binding site [chemical binding]; other site 1126211001555 ATP binding site [chemical binding]; other site 1126211001556 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1126211001557 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211001558 active site 1126211001559 motif I; other site 1126211001560 motif II; other site 1126211001561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211001562 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1126211001563 nudix motif; other site 1126211001564 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1126211001565 Sodium Bile acid symporter family; Region: SBF; cl17470 1126211001566 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1126211001567 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1126211001568 putative NAD(P) binding site [chemical binding]; other site 1126211001569 putative substrate binding site [chemical binding]; other site 1126211001570 catalytic Zn binding site [ion binding]; other site 1126211001571 structural Zn binding site [ion binding]; other site 1126211001572 dimer interface [polypeptide binding]; other site 1126211001573 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1126211001574 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1126211001575 DNA binding residues [nucleotide binding] 1126211001576 putative dimer interface [polypeptide binding]; other site 1126211001577 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1126211001578 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1126211001579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211001580 DNA-binding site [nucleotide binding]; DNA binding site 1126211001581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211001582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211001583 homodimer interface [polypeptide binding]; other site 1126211001584 catalytic residue [active] 1126211001585 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1126211001586 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1126211001587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211001588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211001589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211001590 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1126211001591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211001592 DNA-binding site [nucleotide binding]; DNA binding site 1126211001593 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211001594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211001595 homodimer interface [polypeptide binding]; other site 1126211001596 catalytic residue [active] 1126211001597 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1126211001598 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1126211001599 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1126211001600 NAD binding site [chemical binding]; other site 1126211001601 catalytic Zn binding site [ion binding]; other site 1126211001602 structural Zn binding site [ion binding]; other site 1126211001603 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1126211001604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211001605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211001606 putative substrate translocation pore; other site 1126211001607 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1126211001608 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1126211001609 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1126211001610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1126211001611 K+ potassium transporter; Region: K_trans; cl15781 1126211001612 Histidine kinase; Region: HisKA_3; pfam07730 1126211001613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211001614 ATP binding site [chemical binding]; other site 1126211001615 Mg2+ binding site [ion binding]; other site 1126211001616 G-X-G motif; other site 1126211001617 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1126211001618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211001619 active site 1126211001620 phosphorylation site [posttranslational modification] 1126211001621 intermolecular recognition site; other site 1126211001622 dimerization interface [polypeptide binding]; other site 1126211001623 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1126211001624 DNA binding residues [nucleotide binding] 1126211001625 dimerization interface [polypeptide binding]; other site 1126211001626 MMPL family; Region: MMPL; pfam03176 1126211001627 MMPL family; Region: MMPL; pfam03176 1126211001628 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 1126211001629 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1126211001630 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1126211001631 catalytic triad [active] 1126211001632 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1126211001633 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1126211001634 ABC transporter; Region: ABC_tran_2; pfam12848 1126211001635 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1126211001636 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1126211001637 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211001638 Coenzyme A binding pocket [chemical binding]; other site 1126211001639 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1126211001640 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1126211001641 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1126211001642 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1126211001643 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1126211001644 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1126211001645 dimer interface [polypeptide binding]; other site 1126211001646 active site 1126211001647 metal binding site [ion binding]; metal-binding site 1126211001648 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1126211001649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211001650 putative substrate translocation pore; other site 1126211001651 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1126211001652 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1126211001653 dimer interface [polypeptide binding]; other site 1126211001654 active site 1126211001655 Helix-turn-helix domain; Region: HTH_31; pfam13560 1126211001656 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1126211001657 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1126211001658 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211001659 Coenzyme A binding pocket [chemical binding]; other site 1126211001660 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1126211001661 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1126211001662 DNA binding residues [nucleotide binding] 1126211001663 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1126211001664 EamA-like transporter family; Region: EamA; pfam00892 1126211001665 EamA-like transporter family; Region: EamA; pfam00892 1126211001666 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1126211001667 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1126211001668 nudix motif; other site 1126211001669 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1126211001670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211001671 S-adenosylmethionine binding site [chemical binding]; other site 1126211001672 tartrate dehydrogenase; Provisional; Region: PRK08194 1126211001673 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1126211001674 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1126211001675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211001676 DNA-binding site [nucleotide binding]; DNA binding site 1126211001677 FCD domain; Region: FCD; pfam07729 1126211001678 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1126211001679 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1126211001680 active site 1126211001681 TDP-binding site; other site 1126211001682 acceptor substrate-binding pocket; other site 1126211001683 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1126211001684 Beta-lactamase; Region: Beta-lactamase; pfam00144 1126211001685 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1126211001686 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1126211001687 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1126211001688 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1126211001689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211001690 putative substrate translocation pore; other site 1126211001691 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1126211001692 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211001693 DNA-binding site [nucleotide binding]; DNA binding site 1126211001694 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1126211001695 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1126211001696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211001697 DNA-binding site [nucleotide binding]; DNA binding site 1126211001698 FCD domain; Region: FCD; pfam07729 1126211001699 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1126211001700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211001701 putative substrate translocation pore; other site 1126211001702 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1126211001703 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1126211001704 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211001705 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211001706 amino acid transporter; Region: 2A0306; TIGR00909 1126211001707 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1126211001708 dimanganese center [ion binding]; other site 1126211001709 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1126211001710 putative hydrophobic ligand binding site [chemical binding]; other site 1126211001711 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1126211001712 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1126211001713 putative NADP binding site [chemical binding]; other site 1126211001714 putative dimer interface [polypeptide binding]; other site 1126211001715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211001716 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1126211001717 putative substrate translocation pore; other site 1126211001718 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211001719 thiamine monophosphate kinase; Provisional; Region: PRK05731 1126211001720 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1126211001721 ATP binding site [chemical binding]; other site 1126211001722 dimerization interface [polypeptide binding]; other site 1126211001723 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1126211001724 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1126211001725 Glycoprotease family; Region: Peptidase_M22; pfam00814 1126211001726 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1126211001727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211001728 Coenzyme A binding pocket [chemical binding]; other site 1126211001729 UGMP family protein; Validated; Region: PRK09604 1126211001730 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1126211001731 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1126211001732 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1126211001733 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1126211001734 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1126211001735 ABC transporter; Region: ABC_tran_2; pfam12848 1126211001736 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1126211001737 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1126211001738 trimer interface [polypeptide binding]; other site 1126211001739 dimer interface [polypeptide binding]; other site 1126211001740 putative active site [active] 1126211001741 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1126211001742 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1126211001743 CoA binding domain; Region: CoA_binding; pfam02629 1126211001744 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1126211001745 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1126211001746 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1126211001747 CAAX protease self-immunity; Region: Abi; pfam02517 1126211001748 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1126211001749 oligomerisation interface [polypeptide binding]; other site 1126211001750 mobile loop; other site 1126211001751 roof hairpin; other site 1126211001752 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1126211001753 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1126211001754 ring oligomerisation interface [polypeptide binding]; other site 1126211001755 ATP/Mg binding site [chemical binding]; other site 1126211001756 stacking interactions; other site 1126211001757 hinge regions; other site 1126211001758 AAA ATPase domain; Region: AAA_16; pfam13191 1126211001759 Walker A motif; other site 1126211001760 ATP binding site [chemical binding]; other site 1126211001761 Walker B motif; other site 1126211001762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211001763 binding surface 1126211001764 TPR motif; other site 1126211001765 TPR repeat; Region: TPR_11; pfam13414 1126211001766 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1126211001767 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1126211001768 inhibitor binding site; inhibition site 1126211001769 catalytic Zn binding site [ion binding]; other site 1126211001770 structural Zn binding site [ion binding]; other site 1126211001771 NADP binding site [chemical binding]; other site 1126211001772 tetramer interface [polypeptide binding]; other site 1126211001773 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1126211001774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211001775 putative substrate translocation pore; other site 1126211001776 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1126211001777 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1126211001778 putative substrate binding site [chemical binding]; other site 1126211001779 putative ATP binding site [chemical binding]; other site 1126211001780 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1126211001781 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1126211001782 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 1126211001783 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1126211001784 Repair protein; Region: Repair_PSII; pfam04536 1126211001785 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1126211001786 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1126211001787 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1126211001788 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1126211001789 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1126211001790 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1126211001791 catalytic triad [active] 1126211001792 catalytic triad [active] 1126211001793 oxyanion hole [active] 1126211001794 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1126211001795 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1126211001796 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1126211001797 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1126211001798 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1126211001799 DNA binding residues [nucleotide binding] 1126211001800 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1126211001801 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1126211001802 putative NAD(P) binding site [chemical binding]; other site 1126211001803 catalytic Zn binding site [ion binding]; other site 1126211001804 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1126211001805 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1126211001806 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1126211001807 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1126211001808 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1126211001809 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1126211001810 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1126211001811 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1126211001812 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1126211001813 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1126211001814 MoxR-like ATPases [General function prediction only]; Region: COG0714 1126211001815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211001816 Walker A motif; other site 1126211001817 ATP binding site [chemical binding]; other site 1126211001818 Walker B motif; other site 1126211001819 arginine finger; other site 1126211001820 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1126211001821 Protein of unknown function DUF58; Region: DUF58; pfam01882 1126211001822 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1126211001823 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1126211001824 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1126211001825 GMP synthase; Reviewed; Region: guaA; PRK00074 1126211001826 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1126211001827 AMP/PPi binding site [chemical binding]; other site 1126211001828 candidate oxyanion hole; other site 1126211001829 catalytic triad [active] 1126211001830 potential glutamine specificity residues [chemical binding]; other site 1126211001831 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1126211001832 ATP Binding subdomain [chemical binding]; other site 1126211001833 Ligand Binding sites [chemical binding]; other site 1126211001834 Dimerization subdomain; other site 1126211001835 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1126211001836 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1126211001837 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1126211001838 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1126211001839 tetramer interface [polypeptide binding]; other site 1126211001840 active site 1126211001841 Mg2+/Mn2+ binding site [ion binding]; other site 1126211001842 aspartate aminotransferase; Provisional; Region: PRK05764 1126211001843 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211001844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211001845 homodimer interface [polypeptide binding]; other site 1126211001846 catalytic residue [active] 1126211001847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211001848 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211001849 putative substrate translocation pore; other site 1126211001850 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1126211001851 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1126211001852 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1126211001853 DNA binding residues [nucleotide binding] 1126211001854 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1126211001855 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1126211001856 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1126211001857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1126211001858 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1126211001859 NETI protein; Region: NETI; pfam14044 1126211001860 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1126211001861 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1126211001862 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1126211001863 NAD binding site [chemical binding]; other site 1126211001864 ATP-grasp domain; Region: ATP-grasp; pfam02222 1126211001865 adenylosuccinate lyase; Provisional; Region: PRK07492 1126211001866 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1126211001867 tetramer interface [polypeptide binding]; other site 1126211001868 active site 1126211001869 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1126211001870 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1126211001871 ATP binding site [chemical binding]; other site 1126211001872 active site 1126211001873 substrate binding site [chemical binding]; other site 1126211001874 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1126211001875 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1126211001876 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1126211001877 putative active site [active] 1126211001878 catalytic triad [active] 1126211001879 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1126211001880 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1126211001881 dimerization interface [polypeptide binding]; other site 1126211001882 ATP binding site [chemical binding]; other site 1126211001883 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1126211001884 dimerization interface [polypeptide binding]; other site 1126211001885 ATP binding site [chemical binding]; other site 1126211001886 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1126211001887 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1126211001888 active site 1126211001889 tetramer interface [polypeptide binding]; other site 1126211001890 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1126211001891 active site 1126211001892 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1126211001893 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1126211001894 dimerization interface [polypeptide binding]; other site 1126211001895 putative ATP binding site [chemical binding]; other site 1126211001896 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1126211001897 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1126211001898 active site 1126211001899 substrate binding site [chemical binding]; other site 1126211001900 cosubstrate binding site; other site 1126211001901 catalytic site [active] 1126211001902 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1126211001903 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1126211001904 purine monophosphate binding site [chemical binding]; other site 1126211001905 dimer interface [polypeptide binding]; other site 1126211001906 putative catalytic residues [active] 1126211001907 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1126211001908 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1126211001909 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1126211001910 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1126211001911 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1126211001912 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1126211001913 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1126211001914 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1126211001915 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1126211001916 active site 1126211001917 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1126211001918 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1126211001919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1126211001920 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1126211001921 active site 1126211001922 FMN binding site [chemical binding]; other site 1126211001923 substrate binding site [chemical binding]; other site 1126211001924 3Fe-4S cluster binding site [ion binding]; other site 1126211001925 PcrB family; Region: PcrB; pfam01884 1126211001926 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1126211001927 substrate binding site [chemical binding]; other site 1126211001928 putative active site [active] 1126211001929 dimer interface [polypeptide binding]; other site 1126211001930 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1126211001931 Part of AAA domain; Region: AAA_19; pfam13245 1126211001932 Family description; Region: UvrD_C_2; pfam13538 1126211001933 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1126211001934 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1126211001935 nucleotide binding pocket [chemical binding]; other site 1126211001936 K-X-D-G motif; other site 1126211001937 catalytic site [active] 1126211001938 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1126211001939 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1126211001940 Helix-hairpin-helix motif; Region: HHH; pfam00633 1126211001941 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1126211001942 Dimer interface [polypeptide binding]; other site 1126211001943 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1126211001944 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1126211001945 putative dimer interface [polypeptide binding]; other site 1126211001946 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1126211001947 putative dimer interface [polypeptide binding]; other site 1126211001948 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1126211001949 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1126211001950 active site 1126211001951 ATP binding site [chemical binding]; other site 1126211001952 substrate binding site [chemical binding]; other site 1126211001953 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1126211001954 MgtC family; Region: MgtC; pfam02308 1126211001955 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1126211001956 Na binding site [ion binding]; other site 1126211001957 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1126211001958 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1126211001959 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1126211001960 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1126211001961 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1126211001962 GatB domain; Region: GatB_Yqey; pfam02637 1126211001963 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211001964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211001965 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1126211001966 Protein export membrane protein; Region: SecD_SecF; cl14618 1126211001967 putative lipid kinase; Reviewed; Region: PRK13337 1126211001968 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1126211001969 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1126211001970 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1126211001971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211001972 S-adenosylmethionine binding site [chemical binding]; other site 1126211001973 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1126211001974 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1126211001975 Walker A/P-loop; other site 1126211001976 ATP binding site [chemical binding]; other site 1126211001977 Q-loop/lid; other site 1126211001978 ABC transporter signature motif; other site 1126211001979 Walker B; other site 1126211001980 D-loop; other site 1126211001981 H-loop/switch region; other site 1126211001982 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1126211001983 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1126211001984 FtsX-like permease family; Region: FtsX; pfam02687 1126211001985 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1126211001986 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1126211001987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211001988 Walker A/P-loop; other site 1126211001989 ATP binding site [chemical binding]; other site 1126211001990 Q-loop/lid; other site 1126211001991 ABC transporter signature motif; other site 1126211001992 Walker B; other site 1126211001993 D-loop; other site 1126211001994 H-loop/switch region; other site 1126211001995 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1126211001996 Protein of unknown function, DUF600; Region: DUF600; cl04640 1126211001997 Protein of unknown function, DUF600; Region: DUF600; pfam04634 1126211001998 Protein of unknown function, DUF600; Region: DUF600; cl04640 1126211001999 Protein of unknown function, DUF600; Region: DUF600; cl04640 1126211002000 Protein of unknown function, DUF600; Region: DUF600; cl04640 1126211002001 Protein of unknown function, DUF600; Region: DUF600; cl04640 1126211002002 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1126211002003 LXG domain of WXG superfamily; Region: LXG; pfam04740 1126211002004 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 1126211002005 hypothetical protein; Provisional; Region: PRK12378 1126211002006 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1126211002007 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1126211002008 CotJB protein; Region: CotJB; pfam12652 1126211002009 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1126211002010 dimanganese center [ion binding]; other site 1126211002011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211002012 Coenzyme A binding pocket [chemical binding]; other site 1126211002013 YesK-like protein; Region: YesK; pfam14150 1126211002014 Predicted membrane protein [Function unknown]; Region: COG2323 1126211002015 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1126211002016 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1126211002017 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1126211002018 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1126211002019 Uncharacterized small protein [Function unknown]; Region: COG5583 1126211002020 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1126211002021 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1126211002022 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211002023 MarR family; Region: MarR; pfam01047 1126211002024 hypothetical protein; Provisional; Region: PRK06847 1126211002025 hypothetical protein; Provisional; Region: PRK07236 1126211002026 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1126211002027 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1126211002028 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1126211002029 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1126211002030 Cytochrome P450; Region: p450; pfam00067 1126211002031 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1126211002032 Flavodoxin; Region: Flavodoxin_1; pfam00258 1126211002033 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1126211002034 FAD binding pocket [chemical binding]; other site 1126211002035 FAD binding motif [chemical binding]; other site 1126211002036 catalytic residues [active] 1126211002037 NAD binding pocket [chemical binding]; other site 1126211002038 phosphate binding motif [ion binding]; other site 1126211002039 beta-alpha-beta structure motif; other site 1126211002040 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1126211002041 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1126211002042 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1126211002043 Walker A/P-loop; other site 1126211002044 ATP binding site [chemical binding]; other site 1126211002045 Q-loop/lid; other site 1126211002046 ABC transporter signature motif; other site 1126211002047 Walker B; other site 1126211002048 D-loop; other site 1126211002049 H-loop/switch region; other site 1126211002050 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1126211002051 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1126211002052 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1126211002053 Sulfatase; Region: Sulfatase; pfam00884 1126211002054 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1126211002055 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1126211002056 substrate binding site; other site 1126211002057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1126211002058 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1126211002059 NAD(P) binding site [chemical binding]; other site 1126211002060 active site 1126211002061 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1126211002062 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1126211002063 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1126211002064 active site 1126211002065 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1126211002066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211002067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211002068 putative substrate translocation pore; other site 1126211002069 amino acid transporter; Region: 2A0306; TIGR00909 1126211002070 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1126211002071 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1126211002072 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1126211002073 NAD(P) binding site [chemical binding]; other site 1126211002074 catalytic residues [active] 1126211002075 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1126211002076 dimer interface [polypeptide binding]; other site 1126211002077 putative CheW interface [polypeptide binding]; other site 1126211002078 oxidoreductase; Provisional; Region: PRK07985 1126211002079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1126211002080 NAD(P) binding site [chemical binding]; other site 1126211002081 active site 1126211002082 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1126211002083 putative metal binding site; other site 1126211002084 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1126211002085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211002086 Walker A/P-loop; other site 1126211002087 ATP binding site [chemical binding]; other site 1126211002088 Q-loop/lid; other site 1126211002089 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1126211002090 ABC transporter signature motif; other site 1126211002091 Walker B; other site 1126211002092 D-loop; other site 1126211002093 ABC transporter; Region: ABC_tran_2; pfam12848 1126211002094 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1126211002095 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1126211002096 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1126211002097 DNA binding residues [nucleotide binding] 1126211002098 putative dimer interface [polypeptide binding]; other site 1126211002099 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1126211002100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211002101 putative substrate translocation pore; other site 1126211002102 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1126211002103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211002104 Walker A/P-loop; other site 1126211002105 ATP binding site [chemical binding]; other site 1126211002106 Q-loop/lid; other site 1126211002107 ABC transporter signature motif; other site 1126211002108 Walker B; other site 1126211002109 D-loop; other site 1126211002110 H-loop/switch region; other site 1126211002111 ABC transporter; Region: ABC_tran_2; pfam12848 1126211002112 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1126211002113 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1126211002114 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1126211002115 ATP binding site [chemical binding]; other site 1126211002116 Mg++ binding site [ion binding]; other site 1126211002117 motif III; other site 1126211002118 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211002119 nucleotide binding region [chemical binding]; other site 1126211002120 ATP-binding site [chemical binding]; other site 1126211002121 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1126211002122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211002123 Coenzyme A binding pocket [chemical binding]; other site 1126211002124 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1126211002125 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1126211002126 NAD(P) binding site [chemical binding]; other site 1126211002127 substrate binding site [chemical binding]; other site 1126211002128 dimer interface [polypeptide binding]; other site 1126211002129 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1126211002130 Heat induced stress protein YflT; Region: YflT; pfam11181 1126211002131 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1126211002132 Amb_all domain; Region: Amb_all; smart00656 1126211002133 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1126211002134 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1126211002135 transmembrane helices; other site 1126211002136 BclB C-terminal domain; Region: exospore_TM; TIGR03721 1126211002137 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1126211002138 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211002139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211002140 dimer interface [polypeptide binding]; other site 1126211002141 phosphorylation site [posttranslational modification] 1126211002142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211002143 ATP binding site [chemical binding]; other site 1126211002144 Mg2+ binding site [ion binding]; other site 1126211002145 G-X-G motif; other site 1126211002146 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1126211002147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211002148 active site 1126211002149 phosphorylation site [posttranslational modification] 1126211002150 intermolecular recognition site; other site 1126211002151 dimerization interface [polypeptide binding]; other site 1126211002152 Histidine kinase; Region: His_kinase; pfam06580 1126211002153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211002154 ATP binding site [chemical binding]; other site 1126211002155 Mg2+ binding site [ion binding]; other site 1126211002156 G-X-G motif; other site 1126211002157 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1126211002158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211002159 active site 1126211002160 phosphorylation site [posttranslational modification] 1126211002161 intermolecular recognition site; other site 1126211002162 dimerization interface [polypeptide binding]; other site 1126211002163 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1126211002164 DNA binding site [nucleotide binding] 1126211002165 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1126211002166 active site 1126211002167 catalytic site [active] 1126211002168 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1126211002169 PAS domain; Region: PAS; smart00091 1126211002170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211002171 ATP binding site [chemical binding]; other site 1126211002172 Mg2+ binding site [ion binding]; other site 1126211002173 G-X-G motif; other site 1126211002174 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1126211002175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211002176 active site 1126211002177 phosphorylation site [posttranslational modification] 1126211002178 intermolecular recognition site; other site 1126211002179 dimerization interface [polypeptide binding]; other site 1126211002180 Transcriptional regulator; Region: CitT; pfam12431 1126211002181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1126211002182 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1126211002183 Citrate transporter; Region: CitMHS; pfam03600 1126211002184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1126211002185 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1126211002186 active site 1126211002187 dimer interface [polypeptide binding]; other site 1126211002188 Acylphosphatase; Region: Acylphosphatase; cl00551 1126211002189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1126211002190 MOSC domain; Region: MOSC; pfam03473 1126211002191 3-alpha domain; Region: 3-alpha; pfam03475 1126211002192 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1126211002193 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1126211002194 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1126211002195 active site 1126211002196 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1126211002197 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1126211002198 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1126211002199 active site turn [active] 1126211002200 phosphorylation site [posttranslational modification] 1126211002201 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1126211002202 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1126211002203 Sulfatase; Region: Sulfatase; pfam00884 1126211002204 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1126211002205 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1126211002206 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1126211002207 putative dimer interface [polypeptide binding]; other site 1126211002208 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1126211002209 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1126211002210 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1126211002211 active site turn [active] 1126211002212 phosphorylation site [posttranslational modification] 1126211002213 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1126211002214 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1126211002215 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1126211002216 Ca binding site [ion binding]; other site 1126211002217 active site 1126211002218 catalytic site [active] 1126211002219 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1126211002220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211002221 DNA-binding site [nucleotide binding]; DNA binding site 1126211002222 UTRA domain; Region: UTRA; pfam07702 1126211002223 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1126211002224 dimer interface [polypeptide binding]; other site 1126211002225 FMN binding site [chemical binding]; other site 1126211002226 YibE/F-like protein; Region: YibE_F; pfam07907 1126211002227 YibE/F-like protein; Region: YibE_F; pfam07907 1126211002228 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1126211002229 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1126211002230 active site 1126211002231 metal binding site [ion binding]; metal-binding site 1126211002232 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1126211002233 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1126211002234 active site 1126211002235 metal binding site [ion binding]; metal-binding site 1126211002236 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1126211002237 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1126211002238 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1126211002239 proposed catalytic triad [active] 1126211002240 conserved cys residue [active] 1126211002241 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1126211002242 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1126211002243 DNA binding site [nucleotide binding] 1126211002244 domain linker motif; other site 1126211002245 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1126211002246 putative dimerization interface [polypeptide binding]; other site 1126211002247 putative ligand binding site [chemical binding]; other site 1126211002248 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1126211002249 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1126211002250 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1126211002251 shikimate binding site; other site 1126211002252 NAD(P) binding site [chemical binding]; other site 1126211002253 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1126211002254 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1126211002255 active site 1126211002256 catalytic residue [active] 1126211002257 dimer interface [polypeptide binding]; other site 1126211002258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211002259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211002260 putative substrate translocation pore; other site 1126211002261 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1126211002262 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1126211002263 active site 1126211002264 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1126211002265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211002266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211002267 putative substrate translocation pore; other site 1126211002268 calcium/proton exchanger (cax); Region: cax; TIGR00378 1126211002269 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1126211002270 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1126211002271 YfkD-like protein; Region: YfkD; pfam14167 1126211002272 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1126211002273 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1126211002274 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1126211002275 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1126211002276 FeS/SAM binding site; other site 1126211002277 YfkB-like domain; Region: YfkB; pfam08756 1126211002278 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1126211002279 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1126211002280 NodB motif; other site 1126211002281 active site 1126211002282 catalytic site [active] 1126211002283 Cd binding site [ion binding]; other site 1126211002284 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1126211002285 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1126211002286 Walker A/P-loop; other site 1126211002287 ATP binding site [chemical binding]; other site 1126211002288 Q-loop/lid; other site 1126211002289 ABC transporter signature motif; other site 1126211002290 Walker B; other site 1126211002291 D-loop; other site 1126211002292 H-loop/switch region; other site 1126211002293 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1126211002294 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1126211002295 active site 1126211002296 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211002297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211002298 active site 1126211002299 phosphorylation site [posttranslational modification] 1126211002300 intermolecular recognition site; other site 1126211002301 dimerization interface [polypeptide binding]; other site 1126211002302 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211002303 DNA binding site [nucleotide binding] 1126211002304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211002305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211002306 dimer interface [polypeptide binding]; other site 1126211002307 phosphorylation site [posttranslational modification] 1126211002308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211002309 ATP binding site [chemical binding]; other site 1126211002310 Mg2+ binding site [ion binding]; other site 1126211002311 G-X-G motif; other site 1126211002312 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1126211002313 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1126211002314 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1126211002315 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1126211002316 oligomer interface [polypeptide binding]; other site 1126211002317 metal binding site [ion binding]; metal-binding site 1126211002318 metal binding site [ion binding]; metal-binding site 1126211002319 putative Cl binding site [ion binding]; other site 1126211002320 aspartate ring; other site 1126211002321 basic sphincter; other site 1126211002322 hydrophobic gate; other site 1126211002323 periplasmic entrance; other site 1126211002324 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1126211002325 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1126211002326 minor groove reading motif; other site 1126211002327 helix-hairpin-helix signature motif; other site 1126211002328 substrate binding pocket [chemical binding]; other site 1126211002329 active site 1126211002330 TRAM domain; Region: TRAM; pfam01938 1126211002331 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1126211002332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211002333 S-adenosylmethionine binding site [chemical binding]; other site 1126211002334 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1126211002335 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1126211002336 FMN binding site [chemical binding]; other site 1126211002337 active site 1126211002338 catalytic residues [active] 1126211002339 substrate binding site [chemical binding]; other site 1126211002340 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1126211002341 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1126211002342 tetramer interface [polypeptide binding]; other site 1126211002343 TPP-binding site [chemical binding]; other site 1126211002344 heterodimer interface [polypeptide binding]; other site 1126211002345 phosphorylation loop region [posttranslational modification] 1126211002346 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1126211002347 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1126211002348 alpha subunit interface [polypeptide binding]; other site 1126211002349 TPP binding site [chemical binding]; other site 1126211002350 heterodimer interface [polypeptide binding]; other site 1126211002351 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1126211002352 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1126211002353 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1126211002354 E3 interaction surface; other site 1126211002355 lipoyl attachment site [posttranslational modification]; other site 1126211002356 e3 binding domain; Region: E3_binding; pfam02817 1126211002357 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1126211002358 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1126211002359 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1126211002360 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1126211002361 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1126211002362 GAF domain; Region: GAF; pfam01590 1126211002363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211002364 Walker A motif; other site 1126211002365 ATP binding site [chemical binding]; other site 1126211002366 Walker B motif; other site 1126211002367 arginine finger; other site 1126211002368 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1126211002369 Small acid-soluble spore protein H family; Region: SspH; pfam08141 1126211002370 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1126211002371 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1126211002372 NAD binding site [chemical binding]; other site 1126211002373 sugar binding site [chemical binding]; other site 1126211002374 divalent metal binding site [ion binding]; other site 1126211002375 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1126211002376 dimer interface [polypeptide binding]; other site 1126211002377 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1126211002378 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1126211002379 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1126211002380 putative active site [active] 1126211002381 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1126211002382 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1126211002383 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1126211002384 active site turn [active] 1126211002385 phosphorylation site [posttranslational modification] 1126211002386 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1126211002387 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1126211002388 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211002389 Walker A/P-loop; other site 1126211002390 ATP binding site [chemical binding]; other site 1126211002391 Q-loop/lid; other site 1126211002392 ABC transporter signature motif; other site 1126211002393 Walker B; other site 1126211002394 D-loop; other site 1126211002395 H-loop/switch region; other site 1126211002396 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1126211002397 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1126211002398 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1126211002399 Walker A/P-loop; other site 1126211002400 ATP binding site [chemical binding]; other site 1126211002401 Q-loop/lid; other site 1126211002402 ABC transporter signature motif; other site 1126211002403 Walker B; other site 1126211002404 D-loop; other site 1126211002405 H-loop/switch region; other site 1126211002406 Predicted membrane protein [Function unknown]; Region: COG2259 1126211002407 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1126211002408 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1126211002409 putative metal binding site [ion binding]; other site 1126211002410 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1126211002411 active site 1126211002412 Polyprenyltransferase (cytochrome oxidase assembly factor) [Posttranslational modification, protein turnover, chaperones]; Region: CyoE; COG0109 1126211002413 UbiA prenyltransferase family; Region: UbiA; pfam01040 1126211002414 Predicted transcriptional regulators [Transcription]; Region: COG1695 1126211002415 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1126211002416 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1126211002417 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1126211002418 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1126211002419 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1126211002420 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1126211002421 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1126211002422 DNA polymerase phi; Region: DNA_pol_phi; pfam04931 1126211002423 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1126211002424 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1126211002425 RNAase interaction site [polypeptide binding]; other site 1126211002426 metal-dependent hydrolase; Provisional; Region: PRK13291 1126211002427 DinB superfamily; Region: DinB_2; pfam12867 1126211002428 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211002429 MarR family; Region: MarR; pfam01047 1126211002430 Predicted integral membrane protein [Function unknown]; Region: COG0392 1126211002431 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1126211002432 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1126211002433 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1126211002434 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1126211002435 putative FMN binding site [chemical binding]; other site 1126211002436 YfhD-like protein; Region: YfhD; pfam14151 1126211002437 YfhE-like protein; Region: YfhE; pfam14152 1126211002438 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1126211002439 TIGR01777 family protein; Region: yfcH 1126211002440 putative NAD(P) binding site [chemical binding]; other site 1126211002441 putative active site [active] 1126211002442 recombination regulator RecX; Provisional; Region: recX; PRK14135 1126211002443 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1126211002444 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1126211002445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211002446 putative substrate translocation pore; other site 1126211002447 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1126211002448 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1126211002449 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 1126211002450 WVELL protein; Region: WVELL; pfam14043 1126211002451 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1126211002452 Bacterial SH3 domain; Region: SH3_3; cl17532 1126211002453 SdpI/YhfL protein family; Region: SdpI; pfam13630 1126211002454 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1126211002455 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1126211002456 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1126211002457 Ligand binding site; other site 1126211002458 Putative Catalytic site; other site 1126211002459 DXD motif; other site 1126211002460 Predicted membrane protein [Function unknown]; Region: COG4485 1126211002461 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1126211002462 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1126211002463 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1126211002464 minor groove reading motif; other site 1126211002465 helix-hairpin-helix signature motif; other site 1126211002466 substrate binding pocket [chemical binding]; other site 1126211002467 active site 1126211002468 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1126211002469 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1126211002470 DNA binding and oxoG recognition site [nucleotide binding] 1126211002471 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1126211002472 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1126211002473 putative NAD(P) binding site [chemical binding]; other site 1126211002474 active site 1126211002475 YgaB-like protein; Region: YgaB; pfam14182 1126211002476 hypothetical protein; Provisional; Region: PRK13662 1126211002477 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1126211002478 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1126211002479 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1126211002480 Walker A/P-loop; other site 1126211002481 ATP binding site [chemical binding]; other site 1126211002482 Q-loop/lid; other site 1126211002483 ABC transporter signature motif; other site 1126211002484 Walker B; other site 1126211002485 D-loop; other site 1126211002486 H-loop/switch region; other site 1126211002487 Predicted membrane protein [Function unknown]; Region: COG4129 1126211002488 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1126211002489 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1126211002490 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1126211002491 inhibitor-cofactor binding pocket; inhibition site 1126211002492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211002493 catalytic residue [active] 1126211002494 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1126211002495 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1126211002496 catalytic triad [active] 1126211002497 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1126211002498 metal binding site 2 [ion binding]; metal-binding site 1126211002499 putative DNA binding helix; other site 1126211002500 metal binding site 1 [ion binding]; metal-binding site 1126211002501 dimer interface [polypeptide binding]; other site 1126211002502 structural Zn2+ binding site [ion binding]; other site 1126211002503 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1126211002504 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1126211002505 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1126211002506 active site pocket [active] 1126211002507 oxyanion hole [active] 1126211002508 catalytic triad [active] 1126211002509 active site nucleophile [active] 1126211002510 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1126211002511 ThiC-associated domain; Region: ThiC-associated; pfam13667 1126211002512 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1126211002513 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1126211002514 FAD binding domain; Region: FAD_binding_4; pfam01565 1126211002515 Berberine and berberine like; Region: BBE; pfam08031 1126211002516 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1126211002517 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1126211002518 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1126211002519 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1126211002520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211002521 dimer interface [polypeptide binding]; other site 1126211002522 conserved gate region; other site 1126211002523 putative PBP binding loops; other site 1126211002524 ABC-ATPase subunit interface; other site 1126211002525 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1126211002526 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1126211002527 Walker A/P-loop; other site 1126211002528 ATP binding site [chemical binding]; other site 1126211002529 Q-loop/lid; other site 1126211002530 ABC transporter signature motif; other site 1126211002531 Walker B; other site 1126211002532 D-loop; other site 1126211002533 H-loop/switch region; other site 1126211002534 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1126211002535 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1126211002536 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1126211002537 Walker A/P-loop; other site 1126211002538 ATP binding site [chemical binding]; other site 1126211002539 Q-loop/lid; other site 1126211002540 ABC transporter signature motif; other site 1126211002541 Walker B; other site 1126211002542 D-loop; other site 1126211002543 H-loop/switch region; other site 1126211002544 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1126211002545 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1126211002546 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1126211002547 tetramer interface [polypeptide binding]; other site 1126211002548 heme binding pocket [chemical binding]; other site 1126211002549 NADPH binding site [chemical binding]; other site 1126211002550 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1126211002551 active site 1126211002552 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1126211002553 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1126211002554 Walker A/P-loop; other site 1126211002555 ATP binding site [chemical binding]; other site 1126211002556 Q-loop/lid; other site 1126211002557 ABC transporter signature motif; other site 1126211002558 Walker B; other site 1126211002559 D-loop; other site 1126211002560 H-loop/switch region; other site 1126211002561 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1126211002562 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1126211002563 substrate binding pocket [chemical binding]; other site 1126211002564 membrane-bound complex binding site; other site 1126211002565 hinge residues; other site 1126211002566 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1126211002567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211002568 dimer interface [polypeptide binding]; other site 1126211002569 conserved gate region; other site 1126211002570 putative PBP binding loops; other site 1126211002571 ABC-ATPase subunit interface; other site 1126211002572 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1126211002573 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1126211002574 active site 1126211002575 dimer interface [polypeptide binding]; other site 1126211002576 non-prolyl cis peptide bond; other site 1126211002577 insertion regions; other site 1126211002578 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1126211002579 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211002580 non-specific DNA binding site [nucleotide binding]; other site 1126211002581 salt bridge; other site 1126211002582 sequence-specific DNA binding site [nucleotide binding]; other site 1126211002583 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1126211002584 epoxyqueuosine reductase; Region: TIGR00276 1126211002585 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1126211002586 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1126211002587 Putative amidase domain; Region: Amidase_6; pfam12671 1126211002588 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 1126211002589 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1126211002590 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1126211002591 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1126211002592 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1126211002593 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1126211002594 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1126211002595 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211002596 MarR family; Region: MarR; pfam01047 1126211002597 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1126211002598 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1126211002599 carboxyltransferase (CT) interaction site; other site 1126211002600 biotinylation site [posttranslational modification]; other site 1126211002601 HlyD family secretion protein; Region: HlyD_3; pfam13437 1126211002602 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1126211002603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211002604 putative substrate translocation pore; other site 1126211002605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211002606 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1126211002607 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1126211002608 Predicted transcriptional regulators [Transcription]; Region: COG1725 1126211002609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211002610 DNA-binding site [nucleotide binding]; DNA binding site 1126211002611 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1126211002612 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1126211002613 Walker A/P-loop; other site 1126211002614 ATP binding site [chemical binding]; other site 1126211002615 Q-loop/lid; other site 1126211002616 ABC transporter signature motif; other site 1126211002617 Walker B; other site 1126211002618 D-loop; other site 1126211002619 H-loop/switch region; other site 1126211002620 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1126211002621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211002622 Walker A/P-loop; other site 1126211002623 ATP binding site [chemical binding]; other site 1126211002624 Q-loop/lid; other site 1126211002625 ABC transporter signature motif; other site 1126211002626 Walker B; other site 1126211002627 D-loop; other site 1126211002628 H-loop/switch region; other site 1126211002629 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1126211002630 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1126211002631 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1126211002632 DNA-binding site [nucleotide binding]; DNA binding site 1126211002633 RNA-binding motif; other site 1126211002634 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1126211002635 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1126211002636 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1126211002637 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1126211002638 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1126211002639 metal binding site [ion binding]; metal-binding site 1126211002640 active site 1126211002641 I-site; other site 1126211002642 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1126211002643 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1126211002644 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1126211002645 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1126211002646 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1126211002647 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1126211002648 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1126211002649 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1126211002650 putative active site [active] 1126211002651 putative metal binding site [ion binding]; other site 1126211002652 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1126211002653 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1126211002654 active site 1126211002655 catalytic site [active] 1126211002656 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1126211002657 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1126211002658 active site 1126211002659 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1126211002660 FOG: CBS domain [General function prediction only]; Region: COG0517 1126211002661 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1126211002662 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211002663 motif II; other site 1126211002664 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1126211002665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211002666 Coenzyme A binding pocket [chemical binding]; other site 1126211002667 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1126211002668 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1126211002669 putative active site [active] 1126211002670 catalytic triad [active] 1126211002671 putative dimer interface [polypeptide binding]; other site 1126211002672 aminotransferase; Validated; Region: PRK07678 1126211002673 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1126211002674 inhibitor-cofactor binding pocket; inhibition site 1126211002675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211002676 catalytic residue [active] 1126211002677 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1126211002678 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1126211002679 amphipathic channel; other site 1126211002680 Asn-Pro-Ala signature motifs; other site 1126211002681 glycerol kinase; Provisional; Region: glpK; PRK00047 1126211002682 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1126211002683 N- and C-terminal domain interface [polypeptide binding]; other site 1126211002684 active site 1126211002685 MgATP binding site [chemical binding]; other site 1126211002686 catalytic site [active] 1126211002687 metal binding site [ion binding]; metal-binding site 1126211002688 glycerol binding site [chemical binding]; other site 1126211002689 homotetramer interface [polypeptide binding]; other site 1126211002690 homodimer interface [polypeptide binding]; other site 1126211002691 FBP binding site [chemical binding]; other site 1126211002692 protein IIAGlc interface [polypeptide binding]; other site 1126211002693 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1126211002694 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1126211002695 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1126211002696 active site 1126211002697 substrate binding site [chemical binding]; other site 1126211002698 metal binding site [ion binding]; metal-binding site 1126211002699 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1126211002700 GAF domain; Region: GAF; pfam01590 1126211002701 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1126211002702 Histidine kinase; Region: HisKA_3; pfam07730 1126211002703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211002704 ATP binding site [chemical binding]; other site 1126211002705 Mg2+ binding site [ion binding]; other site 1126211002706 G-X-G motif; other site 1126211002707 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1126211002708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211002709 active site 1126211002710 phosphorylation site [posttranslational modification] 1126211002711 intermolecular recognition site; other site 1126211002712 dimerization interface [polypeptide binding]; other site 1126211002713 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1126211002714 DNA binding residues [nucleotide binding] 1126211002715 dimerization interface [polypeptide binding]; other site 1126211002716 Predicted flavoprotein [General function prediction only]; Region: COG0431 1126211002717 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1126211002718 YhdB-like protein; Region: YhdB; pfam14148 1126211002719 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1126211002720 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211002721 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211002722 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1126211002723 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211002724 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211002725 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211002726 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1126211002727 NlpC/P60 family; Region: NLPC_P60; pfam00877 1126211002728 Transcriptional regulator; Region: Rrf2; cl17282 1126211002729 Rrf2 family protein; Region: rrf2_super; TIGR00738 1126211002730 Conserved TM helix; Region: TM_helix; pfam05552 1126211002731 Conserved TM helix; Region: TM_helix; pfam05552 1126211002732 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1126211002733 SpoVR like protein; Region: SpoVR; pfam04293 1126211002734 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1126211002735 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1126211002736 dimer interface [polypeptide binding]; other site 1126211002737 active site 1126211002738 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211002739 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211002740 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1126211002741 NlpC/P60 family; Region: NLPC_P60; pfam00877 1126211002742 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1126211002743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1126211002744 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1126211002745 dimerization interface [polypeptide binding]; other site 1126211002746 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1126211002747 dimer interface [polypeptide binding]; other site 1126211002748 Citrate synthase; Region: Citrate_synt; pfam00285 1126211002749 active site 1126211002750 citrylCoA binding site [chemical binding]; other site 1126211002751 oxalacetate/citrate binding site [chemical binding]; other site 1126211002752 coenzyme A binding site [chemical binding]; other site 1126211002753 catalytic triad [active] 1126211002754 short chain dehydrogenase; Provisional; Region: PRK06701 1126211002755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1126211002756 NAD(P) binding site [chemical binding]; other site 1126211002757 active site 1126211002758 amino acid transporter; Region: 2A0306; TIGR00909 1126211002759 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1126211002760 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1126211002761 Na2 binding site [ion binding]; other site 1126211002762 putative substrate binding site 1 [chemical binding]; other site 1126211002763 Na binding site 1 [ion binding]; other site 1126211002764 putative substrate binding site 2 [chemical binding]; other site 1126211002765 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1126211002766 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1126211002767 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1126211002768 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1126211002769 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1126211002770 DNA binding residues [nucleotide binding] 1126211002771 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1126211002772 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1126211002773 putative acyl-acceptor binding pocket; other site 1126211002774 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1126211002775 Transporter associated domain; Region: CorC_HlyC; smart01091 1126211002776 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1126211002777 aspartate aminotransferase; Provisional; Region: PRK06836 1126211002778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211002779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211002780 homodimer interface [polypeptide binding]; other site 1126211002781 catalytic residue [active] 1126211002782 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1126211002783 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1126211002784 dimer interface [polypeptide binding]; other site 1126211002785 active site 1126211002786 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1126211002787 Domain of unknown function DUF21; Region: DUF21; pfam01595 1126211002788 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1126211002789 Transporter associated domain; Region: CorC_HlyC; smart01091 1126211002790 camphor resistance protein CrcB; Provisional; Region: PRK14213 1126211002791 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1126211002792 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1126211002793 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1126211002794 active site 1126211002795 catalytic site [active] 1126211002796 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1126211002797 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1126211002798 NAD-dependent deacetylase; Provisional; Region: PRK00481 1126211002799 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1126211002800 NAD+ binding site [chemical binding]; other site 1126211002801 substrate binding site [chemical binding]; other site 1126211002802 Zn binding site [ion binding]; other site 1126211002803 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1126211002804 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1126211002805 NodB motif; other site 1126211002806 active site 1126211002807 catalytic site [active] 1126211002808 Zn binding site [ion binding]; other site 1126211002809 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1126211002810 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1126211002811 homodimer interface [polypeptide binding]; other site 1126211002812 substrate-cofactor binding pocket; other site 1126211002813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211002814 catalytic residue [active] 1126211002815 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1126211002816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211002817 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1126211002818 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1126211002819 Ligand Binding Site [chemical binding]; other site 1126211002820 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1126211002821 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1126211002822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211002823 Walker A/P-loop; other site 1126211002824 ATP binding site [chemical binding]; other site 1126211002825 Q-loop/lid; other site 1126211002826 ABC transporter signature motif; other site 1126211002827 Walker B; other site 1126211002828 D-loop; other site 1126211002829 H-loop/switch region; other site 1126211002830 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1126211002831 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1126211002832 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1126211002833 Walker A/P-loop; other site 1126211002834 ATP binding site [chemical binding]; other site 1126211002835 Q-loop/lid; other site 1126211002836 ABC transporter signature motif; other site 1126211002837 Walker B; other site 1126211002838 D-loop; other site 1126211002839 H-loop/switch region; other site 1126211002840 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1126211002841 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1126211002842 NAD binding site [chemical binding]; other site 1126211002843 substrate binding site [chemical binding]; other site 1126211002844 putative active site [active] 1126211002845 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1126211002846 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1126211002847 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1126211002848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1126211002849 hypothetical protein; Provisional; Region: PRK13676 1126211002850 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1126211002851 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1126211002852 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211002853 active site 1126211002854 motif I; other site 1126211002855 motif II; other site 1126211002856 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1126211002857 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1126211002858 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1126211002859 FeS/SAM binding site; other site 1126211002860 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1126211002861 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1126211002862 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1126211002863 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1126211002864 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1126211002865 TrkA-C domain; Region: TrkA_C; pfam02080 1126211002866 enoyl-CoA hydratase; Provisional; Region: PRK07659 1126211002867 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1126211002868 substrate binding site [chemical binding]; other site 1126211002869 oxyanion hole (OAH) forming residues; other site 1126211002870 trimer interface [polypeptide binding]; other site 1126211002871 YhzD-like protein; Region: YhzD; pfam14120 1126211002872 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1126211002873 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1126211002874 Walker A/P-loop; other site 1126211002875 ATP binding site [chemical binding]; other site 1126211002876 Q-loop/lid; other site 1126211002877 ABC transporter signature motif; other site 1126211002878 Walker B; other site 1126211002879 D-loop; other site 1126211002880 H-loop/switch region; other site 1126211002881 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1126211002882 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1126211002883 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1126211002884 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1126211002885 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1126211002886 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1126211002887 generic binding surface II; other site 1126211002888 generic binding surface I; other site 1126211002889 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1126211002890 Zn2+ binding site [ion binding]; other site 1126211002891 Mg2+ binding site [ion binding]; other site 1126211002892 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1126211002893 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1126211002894 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1126211002895 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1126211002896 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1126211002897 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1126211002898 transcriptional regulator Hpr; Provisional; Region: PRK13777 1126211002899 MarR family; Region: MarR; pfam01047 1126211002900 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1126211002901 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1126211002902 homodimer interface [polypeptide binding]; other site 1126211002903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211002904 substrate-cofactor binding pocket; other site 1126211002905 catalytic residue [active] 1126211002906 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1126211002907 HIT family signature motif; other site 1126211002908 catalytic residue [active] 1126211002909 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1126211002910 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1126211002911 Walker A/P-loop; other site 1126211002912 ATP binding site [chemical binding]; other site 1126211002913 Q-loop/lid; other site 1126211002914 ABC transporter signature motif; other site 1126211002915 Walker B; other site 1126211002916 D-loop; other site 1126211002917 H-loop/switch region; other site 1126211002918 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1126211002919 EcsC protein family; Region: EcsC; pfam12787 1126211002920 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1126211002921 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1126211002922 Transglycosylase; Region: Transgly; pfam00912 1126211002923 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1126211002924 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1126211002925 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1126211002926 substrate binding site [chemical binding]; other site 1126211002927 active site 1126211002928 ferrochelatase; Provisional; Region: PRK12435 1126211002929 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1126211002930 C-terminal domain interface [polypeptide binding]; other site 1126211002931 active site 1126211002932 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1126211002933 active site 1126211002934 N-terminal domain interface [polypeptide binding]; other site 1126211002935 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1126211002936 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1126211002937 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211002938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211002939 Predicted membrane protein [Function unknown]; Region: COG1511 1126211002940 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1126211002941 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1126211002942 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1126211002943 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1126211002944 dimer interface [polypeptide binding]; other site 1126211002945 active site 1126211002946 CoA binding pocket [chemical binding]; other site 1126211002947 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1126211002948 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1126211002949 putative oligomer interface [polypeptide binding]; other site 1126211002950 putative active site [active] 1126211002951 metal binding site [ion binding]; metal-binding site 1126211002952 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1126211002953 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1126211002954 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1126211002955 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1126211002956 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1126211002957 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1126211002958 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1126211002959 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1126211002960 NAD(P) binding site [chemical binding]; other site 1126211002961 putative active site [active] 1126211002962 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1126211002963 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1126211002964 acyl-activating enzyme (AAE) consensus motif; other site 1126211002965 putative AMP binding site [chemical binding]; other site 1126211002966 putative active site [active] 1126211002967 putative CoA binding site [chemical binding]; other site 1126211002968 Peptidase family M48; Region: Peptidase_M48; pfam01435 1126211002969 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1126211002970 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1126211002971 active site 1126211002972 catalytic residues [active] 1126211002973 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1126211002974 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1126211002975 siderophore binding site; other site 1126211002976 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1126211002977 catalytic core [active] 1126211002978 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1126211002979 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1126211002980 dimer interface [polypeptide binding]; other site 1126211002981 active site 1126211002982 acyl-CoA synthetase; Validated; Region: PRK07638 1126211002983 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1126211002984 acyl-activating enzyme (AAE) consensus motif; other site 1126211002985 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1126211002986 acyl-activating enzyme (AAE) consensus motif; other site 1126211002987 AMP binding site [chemical binding]; other site 1126211002988 active site 1126211002989 CoA binding site [chemical binding]; other site 1126211002990 BioY family; Region: BioY; pfam02632 1126211002991 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1126211002992 heme-binding site [chemical binding]; other site 1126211002993 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1126211002994 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1126211002995 dimer interface [polypeptide binding]; other site 1126211002996 putative CheW interface [polypeptide binding]; other site 1126211002997 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1126211002998 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1126211002999 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1126211003000 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1126211003001 [2Fe-2S] cluster binding site [ion binding]; other site 1126211003002 short chain dehydrogenase; Provisional; Region: PRK06701 1126211003003 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1126211003004 NAD binding site [chemical binding]; other site 1126211003005 metal binding site [ion binding]; metal-binding site 1126211003006 active site 1126211003007 A short protein domain of unknown function; Region: IDEAL; smart00914 1126211003008 ComK protein; Region: ComK; cl11560 1126211003009 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1126211003010 MepB protein; Region: MepB; pfam08877 1126211003011 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1126211003012 putative binding site; other site 1126211003013 putative dimer interface [polypeptide binding]; other site 1126211003014 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1126211003015 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1126211003016 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1126211003017 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1126211003018 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1126211003019 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1126211003020 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1126211003021 Catalytic site [active] 1126211003022 hypothetical protein; Provisional; Region: PRK08244 1126211003023 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1126211003024 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211003025 MarR family; Region: MarR; pfam01047 1126211003026 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1126211003027 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1126211003028 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1126211003029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211003030 putative substrate translocation pore; other site 1126211003031 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211003032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211003033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211003034 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1126211003035 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1126211003036 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1126211003037 dinuclear metal binding motif [ion binding]; other site 1126211003038 Predicted membrane protein [Function unknown]; Region: COG2323 1126211003039 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1126211003040 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1126211003041 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1126211003042 Part of AAA domain; Region: AAA_19; pfam13245 1126211003043 Family description; Region: UvrD_C_2; pfam13538 1126211003044 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1126211003045 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1126211003046 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1126211003047 active site 1126211003048 metal binding site [ion binding]; metal-binding site 1126211003049 DNA binding site [nucleotide binding] 1126211003050 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1126211003051 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1126211003052 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1126211003053 Walker A/P-loop; other site 1126211003054 ATP binding site [chemical binding]; other site 1126211003055 Q-loop/lid; other site 1126211003056 ABC transporter signature motif; other site 1126211003057 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1126211003058 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1126211003059 ABC transporter signature motif; other site 1126211003060 Walker B; other site 1126211003061 D-loop; other site 1126211003062 H-loop/switch region; other site 1126211003063 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1126211003064 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1126211003065 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1126211003066 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1126211003067 Spore germination protein GerPC; Region: GerPC; pfam10737 1126211003068 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1126211003069 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1126211003070 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1126211003071 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1126211003072 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1126211003073 hypothetical protein; Provisional; Region: PRK13673 1126211003074 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1126211003075 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1126211003076 active site 1126211003077 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1126211003078 dimer interface [polypeptide binding]; other site 1126211003079 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1126211003080 Ligand Binding Site [chemical binding]; other site 1126211003081 Molecular Tunnel; other site 1126211003082 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1126211003083 substrate binding pocket [chemical binding]; other site 1126211003084 substrate-Mg2+ binding site; other site 1126211003085 aspartate-rich region 1; other site 1126211003086 aspartate-rich region 2; other site 1126211003087 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1126211003088 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1126211003089 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1126211003090 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1126211003091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1126211003092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1126211003093 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1126211003094 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1126211003095 DNA binding site [nucleotide binding] 1126211003096 domain linker motif; other site 1126211003097 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1126211003098 dimerization interface [polypeptide binding]; other site 1126211003099 ligand binding site [chemical binding]; other site 1126211003100 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1126211003101 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1126211003102 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1126211003103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1126211003104 DinB superfamily; Region: DinB_2; pfam12867 1126211003105 Lysine efflux permease [General function prediction only]; Region: COG1279 1126211003106 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1126211003107 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211003108 DNA-binding site [nucleotide binding]; DNA binding site 1126211003109 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211003110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211003111 homodimer interface [polypeptide binding]; other site 1126211003112 catalytic residue [active] 1126211003113 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1126211003114 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1126211003115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1126211003116 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1126211003117 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1126211003118 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1126211003119 FAD binding site [chemical binding]; other site 1126211003120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1126211003121 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1126211003122 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1126211003123 S1 domain; Region: S1_2; pfam13509 1126211003124 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1126211003125 RNA binding site [nucleotide binding]; other site 1126211003126 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1126211003127 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1126211003128 ligand binding site [chemical binding]; other site 1126211003129 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1126211003130 dimerization interface [polypeptide binding]; other site 1126211003131 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1126211003132 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1126211003133 dimer interface [polypeptide binding]; other site 1126211003134 putative CheW interface [polypeptide binding]; other site 1126211003135 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1126211003136 Cytochrome P450; Region: p450; cl12078 1126211003137 EDD domain protein, DegV family; Region: DegV; TIGR00762 1126211003138 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1126211003139 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1126211003140 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1126211003141 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1126211003142 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1126211003143 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1126211003144 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1126211003145 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1126211003146 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211003147 motif II; other site 1126211003148 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211003149 esterase; Provisional; Region: PRK10566 1126211003150 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1126211003151 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1126211003152 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1126211003153 active site 1126211003154 metal binding site [ion binding]; metal-binding site 1126211003155 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1126211003156 FAD binding domain; Region: FAD_binding_4; pfam01565 1126211003157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211003158 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211003159 putative substrate translocation pore; other site 1126211003160 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1126211003161 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1126211003162 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1126211003163 heterotetramer interface [polypeptide binding]; other site 1126211003164 active site pocket [active] 1126211003165 cleavage site 1126211003166 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1126211003167 nucleotide binding site [chemical binding]; other site 1126211003168 N-acetyl-L-glutamate binding site [chemical binding]; other site 1126211003169 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1126211003170 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1126211003171 inhibitor-cofactor binding pocket; inhibition site 1126211003172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211003173 catalytic residue [active] 1126211003174 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1126211003175 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1126211003176 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1126211003177 catalytic site [active] 1126211003178 subunit interface [polypeptide binding]; other site 1126211003179 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1126211003180 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1126211003181 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1126211003182 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1126211003183 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1126211003184 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1126211003185 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1126211003186 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1126211003187 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1126211003188 YjzC-like protein; Region: YjzC; pfam14168 1126211003189 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1126211003190 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1126211003191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1126211003192 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1126211003193 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1126211003194 putative ligand binding site [chemical binding]; other site 1126211003195 ComZ; Region: ComZ; pfam10815 1126211003196 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1126211003197 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1126211003198 dimer interface [polypeptide binding]; other site 1126211003199 active site 1126211003200 CoA binding pocket [chemical binding]; other site 1126211003201 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1126211003202 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1126211003203 dimer interface [polypeptide binding]; other site 1126211003204 active site 1126211003205 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1126211003206 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1126211003207 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1126211003208 Walker A/P-loop; other site 1126211003209 ATP binding site [chemical binding]; other site 1126211003210 Q-loop/lid; other site 1126211003211 ABC transporter signature motif; other site 1126211003212 Walker B; other site 1126211003213 D-loop; other site 1126211003214 H-loop/switch region; other site 1126211003215 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1126211003216 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1126211003217 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1126211003218 Walker A/P-loop; other site 1126211003219 ATP binding site [chemical binding]; other site 1126211003220 Q-loop/lid; other site 1126211003221 ABC transporter signature motif; other site 1126211003222 Walker B; other site 1126211003223 D-loop; other site 1126211003224 H-loop/switch region; other site 1126211003225 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1126211003226 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1126211003227 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1126211003228 peptide binding site [polypeptide binding]; other site 1126211003229 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1126211003230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211003231 dimer interface [polypeptide binding]; other site 1126211003232 conserved gate region; other site 1126211003233 putative PBP binding loops; other site 1126211003234 ABC-ATPase subunit interface; other site 1126211003235 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1126211003236 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1126211003237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211003238 dimer interface [polypeptide binding]; other site 1126211003239 conserved gate region; other site 1126211003240 putative PBP binding loops; other site 1126211003241 ABC-ATPase subunit interface; other site 1126211003242 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1126211003243 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1126211003244 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1126211003245 peptide binding site [polypeptide binding]; other site 1126211003246 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1126211003247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211003248 dimer interface [polypeptide binding]; other site 1126211003249 conserved gate region; other site 1126211003250 putative PBP binding loops; other site 1126211003251 ABC-ATPase subunit interface; other site 1126211003252 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1126211003253 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1126211003254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211003255 dimer interface [polypeptide binding]; other site 1126211003256 conserved gate region; other site 1126211003257 putative PBP binding loops; other site 1126211003258 ABC-ATPase subunit interface; other site 1126211003259 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1126211003260 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1126211003261 Walker A/P-loop; other site 1126211003262 ATP binding site [chemical binding]; other site 1126211003263 Q-loop/lid; other site 1126211003264 ABC transporter signature motif; other site 1126211003265 Walker B; other site 1126211003266 D-loop; other site 1126211003267 H-loop/switch region; other site 1126211003268 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1126211003269 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1126211003270 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1126211003271 Walker A/P-loop; other site 1126211003272 ATP binding site [chemical binding]; other site 1126211003273 Q-loop/lid; other site 1126211003274 ABC transporter signature motif; other site 1126211003275 Walker B; other site 1126211003276 D-loop; other site 1126211003277 H-loop/switch region; other site 1126211003278 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1126211003279 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1126211003280 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1126211003281 Coenzyme A binding pocket [chemical binding]; other site 1126211003282 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1126211003283 ArsC family; Region: ArsC; pfam03960 1126211003284 putative catalytic residues [active] 1126211003285 thiol/disulfide switch; other site 1126211003286 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1126211003287 adaptor protein; Provisional; Region: PRK02315 1126211003288 Competence protein CoiA-like family; Region: CoiA; cl11541 1126211003289 oligoendopeptidase F; Region: pepF; TIGR00181 1126211003290 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1126211003291 active site 1126211003292 Zn binding site [ion binding]; other site 1126211003293 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1126211003294 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1126211003295 catalytic residues [active] 1126211003296 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1126211003297 heme binding site [chemical binding]; other site 1126211003298 apolar tunnel; other site 1126211003299 dimerization interface [polypeptide binding]; other site 1126211003300 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1126211003301 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1126211003302 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1126211003303 catalytic residue [active] 1126211003304 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1126211003305 putative active site [active] 1126211003306 putative metal binding residues [ion binding]; other site 1126211003307 signature motif; other site 1126211003308 putative triphosphate binding site [ion binding]; other site 1126211003309 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1126211003310 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1126211003311 synthetase active site [active] 1126211003312 NTP binding site [chemical binding]; other site 1126211003313 metal binding site [ion binding]; metal-binding site 1126211003314 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1126211003315 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1126211003316 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1126211003317 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1126211003318 active site 1126211003319 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1126211003320 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1126211003321 active site 1126211003322 metal binding site [ion binding]; metal-binding site 1126211003323 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1126211003324 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1126211003325 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1126211003326 TrkA-N domain; Region: TrkA_N; pfam02254 1126211003327 TrkA-C domain; Region: TrkA_C; pfam02080 1126211003328 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1126211003329 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1126211003330 thiamine phosphate binding site [chemical binding]; other site 1126211003331 active site 1126211003332 pyrophosphate binding site [ion binding]; other site 1126211003333 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1126211003334 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1126211003335 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1126211003336 thiS-thiF/thiG interaction site; other site 1126211003337 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1126211003338 ThiS interaction site; other site 1126211003339 putative active site [active] 1126211003340 tetramer interface [polypeptide binding]; other site 1126211003341 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1126211003342 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1126211003343 ATP binding site [chemical binding]; other site 1126211003344 substrate interface [chemical binding]; other site 1126211003345 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1126211003346 dimer interface [polypeptide binding]; other site 1126211003347 substrate binding site [chemical binding]; other site 1126211003348 ATP binding site [chemical binding]; other site 1126211003349 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1126211003350 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1126211003351 NAD binding site [chemical binding]; other site 1126211003352 homotetramer interface [polypeptide binding]; other site 1126211003353 homodimer interface [polypeptide binding]; other site 1126211003354 substrate binding site [chemical binding]; other site 1126211003355 active site 1126211003356 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1126211003357 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1126211003358 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1126211003359 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1126211003360 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1126211003361 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1126211003362 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1126211003363 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1126211003364 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1126211003365 Part of AAA domain; Region: AAA_19; pfam13245 1126211003366 Family description; Region: UvrD_C_2; pfam13538 1126211003367 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1126211003368 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1126211003369 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1126211003370 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1126211003371 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1126211003372 Walker A/P-loop; other site 1126211003373 ATP binding site [chemical binding]; other site 1126211003374 Q-loop/lid; other site 1126211003375 ABC transporter signature motif; other site 1126211003376 Walker B; other site 1126211003377 D-loop; other site 1126211003378 H-loop/switch region; other site 1126211003379 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1126211003380 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1126211003381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1126211003382 Coenzyme A binding pocket [chemical binding]; other site 1126211003383 hypothetical protein; Provisional; Region: PRK13679 1126211003384 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1126211003385 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1126211003386 Putative esterase; Region: Esterase; pfam00756 1126211003387 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1126211003388 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1126211003389 homodimer interface [polypeptide binding]; other site 1126211003390 substrate-cofactor binding pocket; other site 1126211003391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211003392 catalytic residue [active] 1126211003393 cystathionine beta-lyase; Provisional; Region: PRK08064 1126211003394 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1126211003395 homodimer interface [polypeptide binding]; other site 1126211003396 substrate-cofactor binding pocket; other site 1126211003397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211003398 catalytic residue [active] 1126211003399 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1126211003400 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1126211003401 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1126211003402 Int/Topo IB signature motif; other site 1126211003403 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1126211003404 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211003405 non-specific DNA binding site [nucleotide binding]; other site 1126211003406 salt bridge; other site 1126211003407 sequence-specific DNA binding site [nucleotide binding]; other site 1126211003408 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1126211003409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211003410 non-specific DNA binding site [nucleotide binding]; other site 1126211003411 sequence-specific DNA binding site [nucleotide binding]; other site 1126211003412 salt bridge; other site 1126211003413 Helix-turn-helix domain; Region: HTH_17; pfam12728 1126211003414 Homeodomain-like domain; Region: HTH_23; pfam13384 1126211003415 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1126211003416 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1126211003417 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1126211003418 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 1126211003419 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1126211003420 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1126211003421 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1126211003422 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1126211003423 catalytic residue [active] 1126211003424 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1126211003425 Peptidase family M23; Region: Peptidase_M23; pfam01551 1126211003426 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1126211003427 LXG domain of WXG superfamily; Region: LXG; pfam04740 1126211003428 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1126211003429 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1126211003430 nucleotide binding site/active site [active] 1126211003431 HIT family signature motif; other site 1126211003432 catalytic residue [active] 1126211003433 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1126211003434 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1126211003435 active site 1126211003436 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1126211003437 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1126211003438 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1126211003439 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211003440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211003441 putative substrate translocation pore; other site 1126211003442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211003443 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1126211003444 putative Zn2+ binding site [ion binding]; other site 1126211003445 putative DNA binding site [nucleotide binding]; other site 1126211003446 dimerization interface [polypeptide binding]; other site 1126211003447 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1126211003448 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1126211003449 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1126211003450 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1126211003451 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1126211003452 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1126211003453 NAD binding site [chemical binding]; other site 1126211003454 homodimer interface [polypeptide binding]; other site 1126211003455 active site 1126211003456 substrate binding site [chemical binding]; other site 1126211003457 galactokinase; Provisional; Region: PRK05322 1126211003458 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1126211003459 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1126211003460 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1126211003461 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1126211003462 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1126211003463 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 1126211003464 active site 1126211003465 P-loop; other site 1126211003466 phosphorylation site [posttranslational modification] 1126211003467 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1126211003468 methionine cluster; other site 1126211003469 active site 1126211003470 phosphorylation site [posttranslational modification] 1126211003471 metal binding site [ion binding]; metal-binding site 1126211003472 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1126211003473 beta-galactosidase; Region: BGL; TIGR03356 1126211003474 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1126211003475 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1126211003476 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1126211003477 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1126211003478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211003479 motif II; other site 1126211003480 hypothetical protein; Provisional; Region: PRK09272 1126211003481 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211003482 MarR family; Region: MarR; pfam01047 1126211003483 MgtC family; Region: MgtC; pfam02308 1126211003484 Putative motility protein; Region: YjfB_motility; pfam14070 1126211003485 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1126211003486 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1126211003487 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1126211003488 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1126211003489 catalytic loop [active] 1126211003490 iron binding site [ion binding]; other site 1126211003491 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 1126211003492 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1126211003493 4Fe-4S binding domain; Region: Fer4; pfam00037 1126211003494 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1126211003495 [4Fe-4S] binding site [ion binding]; other site 1126211003496 molybdopterin cofactor binding site; other site 1126211003497 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1126211003498 molybdopterin cofactor binding site; other site 1126211003499 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1126211003500 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1126211003501 Cytochrome P450; Region: p450; cl12078 1126211003502 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1126211003503 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1126211003504 active site 1126211003505 TDP-binding site; other site 1126211003506 acceptor substrate-binding pocket; other site 1126211003507 homodimer interface [polypeptide binding]; other site 1126211003508 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1126211003509 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1126211003510 active site 1126211003511 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1126211003512 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1126211003513 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1126211003514 Walker A/P-loop; other site 1126211003515 ATP binding site [chemical binding]; other site 1126211003516 Q-loop/lid; other site 1126211003517 ABC transporter signature motif; other site 1126211003518 Walker B; other site 1126211003519 D-loop; other site 1126211003520 H-loop/switch region; other site 1126211003521 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1126211003522 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1126211003523 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1126211003524 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1126211003525 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1126211003526 Glucuronate isomerase; Region: UxaC; pfam02614 1126211003527 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1126211003528 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1126211003529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211003530 putative substrate translocation pore; other site 1126211003531 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1126211003532 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1126211003533 DNA binding site [nucleotide binding] 1126211003534 domain linker motif; other site 1126211003535 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1126211003536 dimerization interface [polypeptide binding]; other site 1126211003537 ligand binding site [chemical binding]; other site 1126211003538 altronate oxidoreductase; Provisional; Region: PRK03643 1126211003539 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1126211003540 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1126211003541 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1126211003542 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1126211003543 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1126211003544 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1126211003545 DinB family; Region: DinB; cl17821 1126211003546 DinB superfamily; Region: DinB_2; pfam12867 1126211003547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211003548 binding surface 1126211003549 TPR motif; other site 1126211003550 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211003551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1126211003552 binding surface 1126211003553 TPR motif; other site 1126211003554 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1126211003555 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1126211003556 amidase catalytic site [active] 1126211003557 Zn binding residues [ion binding]; other site 1126211003558 substrate binding site [chemical binding]; other site 1126211003559 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1126211003560 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211003561 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1126211003562 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1126211003563 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1126211003564 pentamer interface [polypeptide binding]; other site 1126211003565 dodecaamer interface [polypeptide binding]; other site 1126211003566 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1126211003567 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1126211003568 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1126211003569 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211003570 non-specific DNA binding site [nucleotide binding]; other site 1126211003571 salt bridge; other site 1126211003572 sequence-specific DNA binding site [nucleotide binding]; other site 1126211003573 hypothetical protein; Provisional; Region: PRK06921 1126211003574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211003575 Walker A motif; other site 1126211003576 ATP binding site [chemical binding]; other site 1126211003577 Walker B motif; other site 1126211003578 positive control sigma-like factor; Validated; Region: PRK06930 1126211003579 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1126211003580 DNA binding residues [nucleotide binding] 1126211003581 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1126211003582 Terminase small subunit; Region: Terminase_2; cl01513 1126211003583 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 1126211003584 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1126211003585 Haemolysin XhlA; Region: XhlA; pfam10779 1126211003586 Phage lysis protein, holin; Region: Phage_holin; pfam04688 1126211003587 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1126211003588 amidase catalytic site [active] 1126211003589 Zn binding residues [ion binding]; other site 1126211003590 substrate binding site [chemical binding]; other site 1126211003591 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211003592 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1126211003593 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1126211003594 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1126211003595 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1126211003596 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1126211003597 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1126211003598 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1126211003599 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1126211003600 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1126211003601 Zn binding site [ion binding]; other site 1126211003602 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1126211003603 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1126211003604 Zn binding site [ion binding]; other site 1126211003605 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1126211003606 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1126211003607 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1126211003608 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1126211003609 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1126211003610 Ligand binding site; other site 1126211003611 Putative Catalytic site; other site 1126211003612 DXD motif; other site 1126211003613 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1126211003614 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1126211003615 protein binding site [polypeptide binding]; other site 1126211003616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211003617 putative substrate translocation pore; other site 1126211003618 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1126211003619 D-aminopeptidase; Region: Peptidase_M55; pfam04951 1126211003620 active site 1126211003621 metal binding site [ion binding]; metal-binding site 1126211003622 SxDxEG motif; other site 1126211003623 homopentamer interface [polypeptide binding]; other site 1126211003624 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1126211003625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211003626 dimer interface [polypeptide binding]; other site 1126211003627 conserved gate region; other site 1126211003628 putative PBP binding loops; other site 1126211003629 ABC-ATPase subunit interface; other site 1126211003630 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1126211003631 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1126211003632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211003633 dimer interface [polypeptide binding]; other site 1126211003634 conserved gate region; other site 1126211003635 putative PBP binding loops; other site 1126211003636 ABC-ATPase subunit interface; other site 1126211003637 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1126211003638 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1126211003639 Walker A/P-loop; other site 1126211003640 ATP binding site [chemical binding]; other site 1126211003641 Q-loop/lid; other site 1126211003642 ABC transporter signature motif; other site 1126211003643 Walker B; other site 1126211003644 D-loop; other site 1126211003645 H-loop/switch region; other site 1126211003646 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1126211003647 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1126211003648 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1126211003649 peptide binding site [polypeptide binding]; other site 1126211003650 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1126211003651 dimer interface [polypeptide binding]; other site 1126211003652 catalytic triad [active] 1126211003653 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1126211003654 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1126211003655 active site 1126211003656 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1126211003657 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1126211003658 active site 1126211003659 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1126211003660 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1126211003661 Walker A/P-loop; other site 1126211003662 ATP binding site [chemical binding]; other site 1126211003663 Q-loop/lid; other site 1126211003664 ABC transporter signature motif; other site 1126211003665 Walker B; other site 1126211003666 D-loop; other site 1126211003667 H-loop/switch region; other site 1126211003668 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1126211003669 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1126211003670 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1126211003671 Amidinotransferase; Region: Amidinotransf; pfam02274 1126211003672 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1126211003673 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1126211003674 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1126211003675 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1126211003676 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1126211003677 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1126211003678 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1126211003679 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1126211003680 putative active site [active] 1126211003681 putative substrate binding site [chemical binding]; other site 1126211003682 putative cosubstrate binding site; other site 1126211003683 catalytic site [active] 1126211003684 gamma-glutamyl kinase; Provisional; Region: PRK05429 1126211003685 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1126211003686 nucleotide binding site [chemical binding]; other site 1126211003687 homotetrameric interface [polypeptide binding]; other site 1126211003688 putative phosphate binding site [ion binding]; other site 1126211003689 putative allosteric binding site; other site 1126211003690 PUA domain; Region: PUA; pfam01472 1126211003691 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1126211003692 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1126211003693 putative catalytic cysteine [active] 1126211003694 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1126211003695 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1126211003696 MarR family; Region: MarR; pfam01047 1126211003697 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1126211003698 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1126211003699 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1126211003700 putative metal binding site; other site 1126211003701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211003702 binding surface 1126211003703 TPR motif; other site 1126211003704 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1126211003705 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1126211003706 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1126211003707 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1126211003708 ligand binding site [chemical binding]; other site 1126211003709 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1126211003710 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1126211003711 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1126211003712 THF binding site; other site 1126211003713 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1126211003714 substrate binding site [chemical binding]; other site 1126211003715 THF binding site; other site 1126211003716 zinc-binding site [ion binding]; other site 1126211003717 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1126211003718 active site 1126211003719 catalytic residues [active] 1126211003720 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1126211003721 Cobalt transport protein; Region: CbiQ; pfam02361 1126211003722 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1126211003723 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1126211003724 Walker A/P-loop; other site 1126211003725 ATP binding site [chemical binding]; other site 1126211003726 Q-loop/lid; other site 1126211003727 ABC transporter signature motif; other site 1126211003728 Walker B; other site 1126211003729 D-loop; other site 1126211003730 H-loop/switch region; other site 1126211003731 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1126211003732 Walker A/P-loop; other site 1126211003733 ATP binding site [chemical binding]; other site 1126211003734 Q-loop/lid; other site 1126211003735 ABC transporter signature motif; other site 1126211003736 Walker B; other site 1126211003737 D-loop; other site 1126211003738 H-loop/switch region; other site 1126211003739 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1126211003740 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1126211003741 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211003742 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211003743 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1126211003744 active site 1126211003745 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1126211003746 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1126211003747 MgtE intracellular N domain; Region: MgtE_N; smart00924 1126211003748 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1126211003749 Divalent cation transporter; Region: MgtE; pfam01769 1126211003750 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1126211003751 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1126211003752 DNA binding residues [nucleotide binding] 1126211003753 putative dimer interface [polypeptide binding]; other site 1126211003754 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211003755 MarR family; Region: MarR; pfam01047 1126211003756 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1126211003757 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1126211003758 active site 1126211003759 DNA binding site [nucleotide binding] 1126211003760 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1126211003761 nucleotide binding site [chemical binding]; other site 1126211003762 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1126211003763 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1126211003764 putative homodimer interface [polypeptide binding]; other site 1126211003765 putative DNA binding site [nucleotide binding]; other site 1126211003766 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1126211003767 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1126211003768 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1126211003769 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1126211003770 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1126211003771 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1126211003772 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1126211003773 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1126211003774 heat shock protein HtpX; Provisional; Region: PRK05457 1126211003775 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1126211003776 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1126211003777 Predicted membrane protein [Function unknown]; Region: COG2323 1126211003778 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1126211003779 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1126211003780 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1126211003781 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1126211003782 putative active site [active] 1126211003783 heme pocket [chemical binding]; other site 1126211003784 PAS domain; Region: PAS; smart00091 1126211003785 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1126211003786 PAS domain; Region: PAS; smart00091 1126211003787 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1126211003788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211003789 dimer interface [polypeptide binding]; other site 1126211003790 phosphorylation site [posttranslational modification] 1126211003791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211003792 ATP binding site [chemical binding]; other site 1126211003793 Mg2+ binding site [ion binding]; other site 1126211003794 G-X-G motif; other site 1126211003795 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1126211003796 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1126211003797 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1126211003798 DNA binding site [nucleotide binding] 1126211003799 active site 1126211003800 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1126211003801 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1126211003802 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1126211003803 Phosphotransferase enzyme family; Region: APH; pfam01636 1126211003804 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1126211003805 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1126211003806 putative active site [active] 1126211003807 catalytic triad [active] 1126211003808 putative dimer interface [polypeptide binding]; other site 1126211003809 transaminase; Reviewed; Region: PRK08068 1126211003810 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211003811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211003812 homodimer interface [polypeptide binding]; other site 1126211003813 catalytic residue [active] 1126211003814 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1126211003815 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1126211003816 dimer interface [polypeptide binding]; other site 1126211003817 active site 1126211003818 catalytic residue [active] 1126211003819 metal binding site [ion binding]; metal-binding site 1126211003820 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1126211003821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211003822 motif II; other site 1126211003823 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1126211003824 intersubunit interface [polypeptide binding]; other site 1126211003825 active site 1126211003826 Zn2+ binding site [ion binding]; other site 1126211003827 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1126211003828 Cupin domain; Region: Cupin_2; pfam07883 1126211003829 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1126211003830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211003831 dimer interface [polypeptide binding]; other site 1126211003832 phosphorylation site [posttranslational modification] 1126211003833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211003834 ATP binding site [chemical binding]; other site 1126211003835 Mg2+ binding site [ion binding]; other site 1126211003836 G-X-G motif; other site 1126211003837 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211003838 MarR family; Region: MarR; pfam01047 1126211003839 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1126211003840 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1126211003841 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1126211003842 ligand binding site [chemical binding]; other site 1126211003843 flagellar motor protein MotA; Validated; Region: PRK08124 1126211003844 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1126211003845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211003846 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1126211003847 Walker A motif; other site 1126211003848 ATP binding site [chemical binding]; other site 1126211003849 Walker B motif; other site 1126211003850 arginine finger; other site 1126211003851 UvrB/uvrC motif; Region: UVR; pfam02151 1126211003852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211003853 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1126211003854 Walker A motif; other site 1126211003855 ATP binding site [chemical binding]; other site 1126211003856 Walker B motif; other site 1126211003857 arginine finger; other site 1126211003858 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1126211003859 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1126211003860 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1126211003861 Ligand Binding Site [chemical binding]; other site 1126211003862 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 1126211003863 active site 1126211003864 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1126211003865 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1126211003866 short chain dehydrogenase; Provisional; Region: PRK06500 1126211003867 classical (c) SDRs; Region: SDR_c; cd05233 1126211003868 NAD(P) binding site [chemical binding]; other site 1126211003869 active site 1126211003870 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1126211003871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 1126211003872 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1126211003873 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1126211003874 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1126211003875 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1126211003876 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1126211003877 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1126211003878 catalytic residues [active] 1126211003879 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1126211003880 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1126211003881 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1126211003882 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1126211003883 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1126211003884 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1126211003885 active site 1126211003886 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1126211003887 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1126211003888 DNA binding site [nucleotide binding] 1126211003889 domain linker motif; other site 1126211003890 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1126211003891 putative dimerization interface [polypeptide binding]; other site 1126211003892 putative ligand binding site [chemical binding]; other site 1126211003893 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1126211003894 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1126211003895 PRD domain; Region: PRD; pfam00874 1126211003896 PRD domain; Region: PRD; pfam00874 1126211003897 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1126211003898 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1126211003899 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1126211003900 active site turn [active] 1126211003901 phosphorylation site [posttranslational modification] 1126211003902 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1126211003903 HPr interaction site; other site 1126211003904 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1126211003905 active site 1126211003906 phosphorylation site [posttranslational modification] 1126211003907 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1126211003908 dimerization domain swap beta strand [polypeptide binding]; other site 1126211003909 regulatory protein interface [polypeptide binding]; other site 1126211003910 active site 1126211003911 regulatory phosphorylation site [posttranslational modification]; other site 1126211003912 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1126211003913 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1126211003914 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1126211003915 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1126211003916 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1126211003917 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1126211003918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1126211003919 FeS/SAM binding site; other site 1126211003920 Cache domain; Region: Cache_1; pfam02743 1126211003921 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1126211003922 dimerization interface [polypeptide binding]; other site 1126211003923 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1126211003924 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1126211003925 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1126211003926 dimer interface [polypeptide binding]; other site 1126211003927 putative CheW interface [polypeptide binding]; other site 1126211003928 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1126211003929 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1126211003930 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1126211003931 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1126211003932 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1126211003933 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1126211003934 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1126211003935 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1126211003936 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1126211003937 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1126211003938 putative active site [active] 1126211003939 heme pocket [chemical binding]; other site 1126211003940 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1126211003941 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1126211003942 putative active site [active] 1126211003943 heme pocket [chemical binding]; other site 1126211003944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1126211003945 putative active site [active] 1126211003946 heme pocket [chemical binding]; other site 1126211003947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1126211003948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211003949 dimer interface [polypeptide binding]; other site 1126211003950 phosphorylation site [posttranslational modification] 1126211003951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211003952 ATP binding site [chemical binding]; other site 1126211003953 Mg2+ binding site [ion binding]; other site 1126211003954 G-X-G motif; other site 1126211003955 aminotransferase A; Validated; Region: PRK07683 1126211003956 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211003957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211003958 homodimer interface [polypeptide binding]; other site 1126211003959 catalytic residue [active] 1126211003960 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1126211003961 putative CheA interaction surface; other site 1126211003962 Response regulator receiver domain; Region: Response_reg; pfam00072 1126211003963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211003964 active site 1126211003965 phosphorylation site [posttranslational modification] 1126211003966 intermolecular recognition site; other site 1126211003967 dimerization interface [polypeptide binding]; other site 1126211003968 YkyB-like protein; Region: YkyB; pfam14177 1126211003969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211003970 H+ Antiporter protein; Region: 2A0121; TIGR00900 1126211003971 putative substrate translocation pore; other site 1126211003972 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211003973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1126211003974 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1126211003975 phosphodiesterase YaeI; Provisional; Region: PRK11340 1126211003976 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1126211003977 putative active site [active] 1126211003978 putative metal binding site [ion binding]; other site 1126211003979 short chain dehydrogenase; Provisional; Region: PRK07677 1126211003980 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1126211003981 NAD(P) binding site [chemical binding]; other site 1126211003982 substrate binding site [chemical binding]; other site 1126211003983 homotetramer interface [polypeptide binding]; other site 1126211003984 active site 1126211003985 homodimer interface [polypeptide binding]; other site 1126211003986 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1126211003987 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1126211003988 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1126211003989 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1126211003990 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1126211003991 FOG: CBS domain [General function prediction only]; Region: COG0517 1126211003992 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1126211003993 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1126211003994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1126211003995 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1126211003996 dimerization interface [polypeptide binding]; other site 1126211003997 flavodoxin; Provisional; Region: PRK06703 1126211003998 BNR repeat-like domain; Region: BNR_2; pfam13088 1126211003999 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1126211004000 flavodoxin, short chain; Region: flav_short; TIGR01753 1126211004001 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1126211004002 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1126211004003 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1126211004004 active site 1126211004005 trimer interface [polypeptide binding]; other site 1126211004006 substrate binding site [chemical binding]; other site 1126211004007 CoA binding site [chemical binding]; other site 1126211004008 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1126211004009 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1126211004010 metal binding site [ion binding]; metal-binding site 1126211004011 hypothetical protein; Provisional; Region: PRK03094 1126211004012 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1126211004013 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1126211004014 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1126211004015 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1126211004016 catalytic residues [active] 1126211004017 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1126211004018 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1126211004019 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1126211004020 GTP binding site; other site 1126211004021 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1126211004022 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1126211004023 ATP binding site [chemical binding]; other site 1126211004024 substrate interface [chemical binding]; other site 1126211004025 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1126211004026 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1126211004027 dimer interface [polypeptide binding]; other site 1126211004028 putative functional site; other site 1126211004029 putative MPT binding site; other site 1126211004030 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1126211004031 Walker A motif; other site 1126211004032 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1126211004033 MoaE homodimer interface [polypeptide binding]; other site 1126211004034 MoaD interaction [polypeptide binding]; other site 1126211004035 active site residues [active] 1126211004036 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1126211004037 MoaE interaction surface [polypeptide binding]; other site 1126211004038 MoeB interaction surface [polypeptide binding]; other site 1126211004039 thiocarboxylated glycine; other site 1126211004040 Yip1 domain; Region: Yip1; pfam04893 1126211004041 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1126211004042 HlyD family secretion protein; Region: HlyD_3; pfam13437 1126211004043 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1126211004044 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1126211004045 Walker A/P-loop; other site 1126211004046 ATP binding site [chemical binding]; other site 1126211004047 Q-loop/lid; other site 1126211004048 ABC transporter signature motif; other site 1126211004049 Walker B; other site 1126211004050 D-loop; other site 1126211004051 H-loop/switch region; other site 1126211004052 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1126211004053 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1126211004054 FtsX-like permease family; Region: FtsX; pfam02687 1126211004055 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1126211004056 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1126211004057 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1126211004058 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1126211004059 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1126211004060 putative substrate binding site [chemical binding]; other site 1126211004061 putative ATP binding site [chemical binding]; other site 1126211004062 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1126211004063 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1126211004064 active site 1126211004065 phosphorylation site [posttranslational modification] 1126211004066 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1126211004067 active site 1126211004068 P-loop; other site 1126211004069 phosphorylation site [posttranslational modification] 1126211004070 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1126211004071 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1126211004072 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1126211004073 Catalytic site [active] 1126211004074 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1126211004075 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1126211004076 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1126211004077 ABC transporter; Region: ABC_tran_2; pfam12848 1126211004078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1126211004079 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1126211004080 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1126211004081 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1126211004082 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1126211004083 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1126211004084 rod-share determining protein MreBH; Provisional; Region: PRK13929 1126211004085 MreB and similar proteins; Region: MreB_like; cd10225 1126211004086 nucleotide binding site [chemical binding]; other site 1126211004087 Mg binding site [ion binding]; other site 1126211004088 putative protofilament interaction site [polypeptide binding]; other site 1126211004089 RodZ interaction site [polypeptide binding]; other site 1126211004090 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1126211004091 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1126211004092 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1126211004093 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1126211004094 putative active site [active] 1126211004095 heme pocket [chemical binding]; other site 1126211004096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211004097 dimer interface [polypeptide binding]; other site 1126211004098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211004099 ATP binding site [chemical binding]; other site 1126211004100 Mg2+ binding site [ion binding]; other site 1126211004101 G-X-G motif; other site 1126211004102 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1126211004103 putative active site pocket [active] 1126211004104 dimerization interface [polypeptide binding]; other site 1126211004105 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1126211004106 putative active site pocket [active] 1126211004107 dimerization interface [polypeptide binding]; other site 1126211004108 putative catalytic residue [active] 1126211004109 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1126211004110 TrkA-N domain; Region: TrkA_N; pfam02254 1126211004111 TrkA-C domain; Region: TrkA_C; pfam02080 1126211004112 adenine deaminase; Region: ade; TIGR01178 1126211004113 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1126211004114 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1126211004115 active site 1126211004116 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1126211004117 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1126211004118 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1126211004119 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1126211004120 hypothetical protein; Provisional; Region: PRK13667 1126211004121 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1126211004122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211004123 active site 1126211004124 motif I; other site 1126211004125 motif II; other site 1126211004126 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211004127 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1126211004128 active site 1126211004129 catalytic residues [active] 1126211004130 metal binding site [ion binding]; metal-binding site 1126211004131 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1126211004132 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1126211004133 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1126211004134 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1126211004135 FMN binding site [chemical binding]; other site 1126211004136 substrate binding site [chemical binding]; other site 1126211004137 putative catalytic residue [active] 1126211004138 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211004139 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211004140 active site 1126211004141 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211004142 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211004143 putative NADP binding site [chemical binding]; other site 1126211004144 active site 1126211004145 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211004146 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211004147 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211004148 active site 1126211004149 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211004150 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211004151 putative NADP binding site [chemical binding]; other site 1126211004152 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211004153 active site 1126211004154 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211004155 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211004156 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1126211004157 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211004158 active site 1126211004159 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211004160 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211004161 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211004162 putative NADP binding site [chemical binding]; other site 1126211004163 active site 1126211004164 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211004165 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211004166 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211004167 active site 1126211004168 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211004169 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211004170 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211004171 putative NADP binding site [chemical binding]; other site 1126211004172 active site 1126211004173 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211004174 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211004175 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211004176 active site 1126211004177 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211004178 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211004179 putative NADP binding site [chemical binding]; other site 1126211004180 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211004181 active site 1126211004182 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211004183 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211004184 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1126211004185 active site 1126211004186 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211004187 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211004188 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211004189 putative NADP binding site [chemical binding]; other site 1126211004190 active site 1126211004191 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211004192 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211004193 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211004194 active site 1126211004195 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211004196 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211004197 putative NADP binding site [chemical binding]; other site 1126211004198 active site 1126211004199 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211004200 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211004201 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211004202 active site 1126211004203 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211004204 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211004205 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211004206 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211004207 putative NADP binding site [chemical binding]; other site 1126211004208 active site 1126211004209 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211004210 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211004211 active site 1126211004212 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211004213 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211004214 putative NADP binding site [chemical binding]; other site 1126211004215 KR domain; Region: KR; pfam08659 1126211004216 active site 1126211004217 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211004218 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211004219 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211004220 active site 1126211004221 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211004222 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211004223 putative NADP binding site [chemical binding]; other site 1126211004224 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211004225 active site 1126211004226 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211004227 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211004228 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211004229 active site 1126211004230 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211004231 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211004232 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211004233 putative NADP binding site [chemical binding]; other site 1126211004234 KR domain; Region: KR; pfam08659 1126211004235 active site 1126211004236 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1126211004237 Beta-lactamase; Region: Beta-lactamase; pfam00144 1126211004238 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1126211004239 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1126211004240 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1126211004241 TPP-binding site [chemical binding]; other site 1126211004242 tetramer interface [polypeptide binding]; other site 1126211004243 heterodimer interface [polypeptide binding]; other site 1126211004244 phosphorylation loop region [posttranslational modification] 1126211004245 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1126211004246 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1126211004247 alpha subunit interface [polypeptide binding]; other site 1126211004248 TPP binding site [chemical binding]; other site 1126211004249 heterodimer interface [polypeptide binding]; other site 1126211004250 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1126211004251 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1126211004252 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1126211004253 E3 interaction surface; other site 1126211004254 lipoyl attachment site [posttranslational modification]; other site 1126211004255 e3 binding domain; Region: E3_binding; pfam02817 1126211004256 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1126211004257 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1126211004258 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1126211004259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1126211004260 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1126211004261 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1126211004262 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1126211004263 NodB motif; other site 1126211004264 active site 1126211004265 catalytic site [active] 1126211004266 metal binding site [ion binding]; metal-binding site 1126211004267 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1126211004268 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1126211004269 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1126211004270 homodimer interface [polypeptide binding]; other site 1126211004271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211004272 catalytic residue [active] 1126211004273 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1126211004274 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1126211004275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1126211004276 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1126211004277 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1126211004278 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1126211004279 active site 1126211004280 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1126211004281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211004282 Coenzyme A binding pocket [chemical binding]; other site 1126211004283 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1126211004284 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1126211004285 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1126211004286 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1126211004287 active site 1126211004288 Zn binding site [ion binding]; other site 1126211004289 Putative zinc-finger; Region: zf-HC2; pfam13490 1126211004290 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1126211004291 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1126211004292 G1 box; other site 1126211004293 putative GEF interaction site [polypeptide binding]; other site 1126211004294 GTP/Mg2+ binding site [chemical binding]; other site 1126211004295 Switch I region; other site 1126211004296 G2 box; other site 1126211004297 G3 box; other site 1126211004298 Switch II region; other site 1126211004299 G4 box; other site 1126211004300 G5 box; other site 1126211004301 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1126211004302 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1126211004303 YlaH-like protein; Region: YlaH; pfam14036 1126211004304 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1126211004305 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1126211004306 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1126211004307 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1126211004308 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1126211004309 putative active site [active] 1126211004310 PhoH-like protein; Region: PhoH; pfam02562 1126211004311 Glutaminase; Region: Glutaminase; cl00907 1126211004312 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1126211004313 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1126211004314 sequence-specific DNA binding site [nucleotide binding]; other site 1126211004315 salt bridge; other site 1126211004316 Pancreatic Hormone domain, a regulator of pancreatic and gastrointestinal functions; neuropeptide Y (NPY)b, peptide YY (PYY), and pancreatic polypetide (PP) are closely related; propeptide is enzymatically cleaved to yield the mature active peptide with...; Region: PAH; cl00111 1126211004317 dimerization interface [polypeptide binding]; other site 1126211004318 receptor binding site; other site 1126211004319 Nucleopolyhedrovirus P10 protein; Region: NPV_P10; cl17484 1126211004320 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1126211004321 nucleophilic elbow; other site 1126211004322 catalytic triad; other site 1126211004323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211004324 binding surface 1126211004325 TPR motif; other site 1126211004326 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211004327 Short C-terminal domain; Region: SHOCT; pfam09851 1126211004328 Bacterial SH3 domain; Region: SH3_3; pfam08239 1126211004329 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1126211004330 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 1126211004331 GIY-YIG motif/motif A; other site 1126211004332 putative active site [active] 1126211004333 catalytic site [active] 1126211004334 putative metal binding site [ion binding]; other site 1126211004335 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1126211004336 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1126211004337 Phage integrase family; Region: Phage_integrase; pfam00589 1126211004338 active site 1126211004339 DNA binding site [nucleotide binding] 1126211004340 Int/Topo IB signature motif; other site 1126211004341 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1126211004342 HNH endonuclease; Region: HNH_3; pfam13392 1126211004343 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1126211004344 non-specific DNA binding site [nucleotide binding]; other site 1126211004345 sequence-specific DNA binding site [nucleotide binding]; other site 1126211004346 salt bridge; other site 1126211004347 RNA dependent RNA polymerase; Region: RdRP; pfam05183 1126211004348 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1126211004349 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1126211004350 catalytic residues [active] 1126211004351 catalytic nucleophile [active] 1126211004352 Recombinase; Region: Recombinase; pfam07508 1126211004353 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1126211004354 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1126211004355 Glutaminase; Region: Glutaminase; cl00907 1126211004356 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 1126211004357 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1126211004358 pyruvate carboxylase; Reviewed; Region: PRK12999 1126211004359 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1126211004360 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1126211004361 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1126211004362 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1126211004363 active site 1126211004364 catalytic residues [active] 1126211004365 metal binding site [ion binding]; metal-binding site 1126211004366 homodimer binding site [polypeptide binding]; other site 1126211004367 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1126211004368 carboxyltransferase (CT) interaction site; other site 1126211004369 biotinylation site [posttranslational modification]; other site 1126211004370 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1126211004371 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1126211004372 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1126211004373 UbiA prenyltransferase family; Region: UbiA; pfam01040 1126211004374 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1126211004375 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1126211004376 Cytochrome c; Region: Cytochrom_C; pfam00034 1126211004377 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1126211004378 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1126211004379 D-pathway; other site 1126211004380 Putative ubiquinol binding site [chemical binding]; other site 1126211004381 Low-spin heme (heme b) binding site [chemical binding]; other site 1126211004382 Putative water exit pathway; other site 1126211004383 Binuclear center (heme o3/CuB) [ion binding]; other site 1126211004384 K-pathway; other site 1126211004385 Putative proton exit pathway; other site 1126211004386 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1126211004387 Subunit I/III interface [polypeptide binding]; other site 1126211004388 Subunit III/IV interface [polypeptide binding]; other site 1126211004389 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 1126211004390 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1126211004391 YugN-like family; Region: YugN; pfam08868 1126211004392 FOG: CBS domain [General function prediction only]; Region: COG0517 1126211004393 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1126211004394 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1126211004395 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1126211004396 Putative coat protein; Region: YlbD_coat; pfam14071 1126211004397 YlbE-like protein; Region: YlbE; pfam14003 1126211004398 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1126211004399 hypothetical protein; Provisional; Region: PRK02886 1126211004400 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1126211004401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211004402 S-adenosylmethionine binding site [chemical binding]; other site 1126211004403 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1126211004404 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1126211004405 active site 1126211004406 (T/H)XGH motif; other site 1126211004407 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1126211004408 Nucleoside recognition; Region: Gate; pfam07670 1126211004409 Nucleoside recognition; Region: Gate; pfam07670 1126211004410 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1126211004411 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1126211004412 active site 1126211004413 nucleophile elbow; other site 1126211004414 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1126211004415 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1126211004416 protein binding site [polypeptide binding]; other site 1126211004417 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1126211004418 hypothetical protein; Provisional; Region: PRK13670 1126211004419 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1126211004420 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1126211004421 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1126211004422 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1126211004423 hypothetical protein; Provisional; Region: PRK13688 1126211004424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211004425 Coenzyme A binding pocket [chemical binding]; other site 1126211004426 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1126211004427 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1126211004428 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1126211004429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1126211004430 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 1126211004431 mraZ protein; Region: TIGR00242 1126211004432 MraZ protein; Region: MraZ; pfam02381 1126211004433 MraZ protein; Region: MraZ; pfam02381 1126211004434 MraW methylase family; Region: Methyltransf_5; pfam01795 1126211004435 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1126211004436 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1126211004437 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1126211004438 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1126211004439 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1126211004440 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1126211004441 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1126211004442 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1126211004443 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1126211004444 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1126211004445 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1126211004446 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1126211004447 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1126211004448 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1126211004449 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1126211004450 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1126211004451 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1126211004452 Mg++ binding site [ion binding]; other site 1126211004453 putative catalytic motif [active] 1126211004454 putative substrate binding site [chemical binding]; other site 1126211004455 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1126211004456 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1126211004457 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1126211004458 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1126211004459 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1126211004460 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1126211004461 active site 1126211004462 homodimer interface [polypeptide binding]; other site 1126211004463 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1126211004464 FAD binding domain; Region: FAD_binding_4; pfam01565 1126211004465 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1126211004466 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1126211004467 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1126211004468 Cell division protein FtsQ; Region: FtsQ; pfam03799 1126211004469 cell division protein FtsA; Region: ftsA; TIGR01174 1126211004470 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1126211004471 nucleotide binding site [chemical binding]; other site 1126211004472 Cell division protein FtsA; Region: FtsA; pfam14450 1126211004473 cell division protein FtsZ; Validated; Region: PRK09330 1126211004474 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1126211004475 nucleotide binding site [chemical binding]; other site 1126211004476 SulA interaction site; other site 1126211004477 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1126211004478 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1126211004479 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1126211004480 active site 1126211004481 catalytic triad [active] 1126211004482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1126211004483 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1126211004484 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1126211004485 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1126211004486 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1126211004487 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1126211004488 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1126211004489 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1126211004490 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1126211004491 DNA binding residues [nucleotide binding] 1126211004492 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1126211004493 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1126211004494 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1126211004495 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1126211004496 DNA binding residues [nucleotide binding] 1126211004497 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1126211004498 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1126211004499 Walker A/P-loop; other site 1126211004500 ATP binding site [chemical binding]; other site 1126211004501 Q-loop/lid; other site 1126211004502 ABC transporter signature motif; other site 1126211004503 Walker B; other site 1126211004504 D-loop; other site 1126211004505 H-loop/switch region; other site 1126211004506 acetylornithine deacetylase; Validated; Region: PRK08596 1126211004507 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1126211004508 metal binding site [ion binding]; metal-binding site 1126211004509 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1126211004510 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1126211004511 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1126211004512 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1126211004513 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1126211004514 catalytic residue [active] 1126211004515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1126211004516 YGGT family; Region: YGGT; pfam02325 1126211004517 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1126211004518 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1126211004519 RNA binding surface [nucleotide binding]; other site 1126211004520 DivIVA protein; Region: DivIVA; pfam05103 1126211004521 DivIVA domain; Region: DivI1A_domain; TIGR03544 1126211004522 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1126211004523 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1126211004524 HIGH motif; other site 1126211004525 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1126211004526 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1126211004527 active site 1126211004528 KMSKS motif; other site 1126211004529 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1126211004530 tRNA binding surface [nucleotide binding]; other site 1126211004531 anticodon binding site; other site 1126211004532 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1126211004533 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1126211004534 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1126211004535 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1126211004536 RNA binding surface [nucleotide binding]; other site 1126211004537 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1126211004538 active site 1126211004539 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1126211004540 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1126211004541 active site 1126211004542 uracil-xanthine permease; Region: ncs2; TIGR00801 1126211004543 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1126211004544 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1126211004545 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1126211004546 dihydroorotase; Validated; Region: pyrC; PRK09357 1126211004547 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1126211004548 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1126211004549 active site 1126211004550 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1126211004551 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1126211004552 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1126211004553 catalytic site [active] 1126211004554 subunit interface [polypeptide binding]; other site 1126211004555 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1126211004556 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1126211004557 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1126211004558 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1126211004559 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1126211004560 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1126211004561 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1126211004562 IMP binding site; other site 1126211004563 dimer interface [polypeptide binding]; other site 1126211004564 interdomain contacts; other site 1126211004565 partial ornithine binding site; other site 1126211004566 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1126211004567 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1126211004568 FAD binding pocket [chemical binding]; other site 1126211004569 FAD binding motif [chemical binding]; other site 1126211004570 phosphate binding motif [ion binding]; other site 1126211004571 beta-alpha-beta structure motif; other site 1126211004572 NAD binding pocket [chemical binding]; other site 1126211004573 Iron coordination center [ion binding]; other site 1126211004574 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1126211004575 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1126211004576 heterodimer interface [polypeptide binding]; other site 1126211004577 active site 1126211004578 FMN binding site [chemical binding]; other site 1126211004579 homodimer interface [polypeptide binding]; other site 1126211004580 substrate binding site [chemical binding]; other site 1126211004581 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1126211004582 active site 1126211004583 dimer interface [polypeptide binding]; other site 1126211004584 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1126211004585 active site 1126211004586 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1126211004587 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1126211004588 Active Sites [active] 1126211004589 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1126211004590 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1126211004591 ATP-sulfurylase; Region: ATPS; cd00517 1126211004592 active site 1126211004593 HXXH motif; other site 1126211004594 flexible loop; other site 1126211004595 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1126211004596 AAA domain; Region: AAA_18; pfam13238 1126211004597 ligand-binding site [chemical binding]; other site 1126211004598 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1126211004599 diphthine synthase; Region: dph5; TIGR00522 1126211004600 active site 1126211004601 SAM binding site [chemical binding]; other site 1126211004602 homodimer interface [polypeptide binding]; other site 1126211004603 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1126211004604 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1126211004605 putative active site [active] 1126211004606 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1126211004607 putative active site [active] 1126211004608 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1126211004609 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1126211004610 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1126211004611 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1126211004612 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1126211004613 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1126211004614 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1126211004615 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1126211004616 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1126211004617 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211004618 motif II; other site 1126211004619 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1126211004620 TIGR00255 family protein; Region: TIGR00255 1126211004621 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1126211004622 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1126211004623 hypothetical protein; Provisional; Region: PRK04323 1126211004624 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1126211004625 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1126211004626 catalytic site [active] 1126211004627 G-X2-G-X-G-K; other site 1126211004628 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1126211004629 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1126211004630 Flavoprotein; Region: Flavoprotein; pfam02441 1126211004631 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1126211004632 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1126211004633 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1126211004634 ATP binding site [chemical binding]; other site 1126211004635 putative Mg++ binding site [ion binding]; other site 1126211004636 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211004637 nucleotide binding region [chemical binding]; other site 1126211004638 ATP-binding site [chemical binding]; other site 1126211004639 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1126211004640 active site 1126211004641 catalytic residues [active] 1126211004642 metal binding site [ion binding]; metal-binding site 1126211004643 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1126211004644 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1126211004645 putative active site [active] 1126211004646 substrate binding site [chemical binding]; other site 1126211004647 putative cosubstrate binding site; other site 1126211004648 catalytic site [active] 1126211004649 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1126211004650 substrate binding site [chemical binding]; other site 1126211004651 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1126211004652 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1126211004653 putative RNA binding site [nucleotide binding]; other site 1126211004654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211004655 S-adenosylmethionine binding site [chemical binding]; other site 1126211004656 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1126211004657 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1126211004658 FeS/SAM binding site; other site 1126211004659 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1126211004660 Protein phosphatase 2C; Region: PP2C; pfam00481 1126211004661 active site 1126211004662 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1126211004663 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1126211004664 active site 1126211004665 ATP binding site [chemical binding]; other site 1126211004666 substrate binding site [chemical binding]; other site 1126211004667 activation loop (A-loop); other site 1126211004668 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1126211004669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1126211004670 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1126211004671 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1126211004672 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1126211004673 GTPase RsgA; Reviewed; Region: PRK00098 1126211004674 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1126211004675 RNA binding site [nucleotide binding]; other site 1126211004676 homodimer interface [polypeptide binding]; other site 1126211004677 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1126211004678 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1126211004679 GTP/Mg2+ binding site [chemical binding]; other site 1126211004680 G4 box; other site 1126211004681 G5 box; other site 1126211004682 G1 box; other site 1126211004683 Switch I region; other site 1126211004684 G2 box; other site 1126211004685 G3 box; other site 1126211004686 Switch II region; other site 1126211004687 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1126211004688 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1126211004689 substrate binding site [chemical binding]; other site 1126211004690 hexamer interface [polypeptide binding]; other site 1126211004691 metal binding site [ion binding]; metal-binding site 1126211004692 Thiamine pyrophosphokinase; Region: TPK; cd07995 1126211004693 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1126211004694 active site 1126211004695 dimerization interface [polypeptide binding]; other site 1126211004696 thiamine binding site [chemical binding]; other site 1126211004697 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 1126211004698 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1126211004699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1126211004700 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1126211004701 DAK2 domain; Region: Dak2; pfam02734 1126211004702 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1126211004703 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1126211004704 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1126211004705 putative L-serine binding site [chemical binding]; other site 1126211004706 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1126211004707 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1126211004708 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1126211004709 Y-family of DNA polymerases; Region: PolY; cl12025 1126211004710 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1126211004711 generic binding surface II; other site 1126211004712 ssDNA binding site; other site 1126211004713 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1126211004714 ATP binding site [chemical binding]; other site 1126211004715 putative Mg++ binding site [ion binding]; other site 1126211004716 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211004717 nucleotide binding region [chemical binding]; other site 1126211004718 ATP-binding site [chemical binding]; other site 1126211004719 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1126211004720 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1126211004721 putative phosphate acyltransferase; Provisional; Region: PRK05331 1126211004722 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1126211004723 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1126211004724 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1126211004725 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1126211004726 NAD(P) binding site [chemical binding]; other site 1126211004727 homotetramer interface [polypeptide binding]; other site 1126211004728 homodimer interface [polypeptide binding]; other site 1126211004729 active site 1126211004730 acyl carrier protein; Provisional; Region: acpP; PRK00982 1126211004731 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1126211004732 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1126211004733 dimerization interface [polypeptide binding]; other site 1126211004734 active site 1126211004735 metal binding site [ion binding]; metal-binding site 1126211004736 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1126211004737 dsRNA binding site [nucleotide binding]; other site 1126211004738 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1126211004739 AAA domain; Region: AAA_23; pfam13476 1126211004740 Walker A/P-loop; other site 1126211004741 ATP binding site [chemical binding]; other site 1126211004742 Q-loop/lid; other site 1126211004743 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1126211004744 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1126211004745 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1126211004746 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1126211004747 GTP binding site [chemical binding]; other site 1126211004748 Phosphotransferase enzyme family; Region: APH; pfam01636 1126211004749 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1126211004750 active site 1126211004751 ATP binding site [chemical binding]; other site 1126211004752 putative DNA-binding protein; Validated; Region: PRK00118 1126211004753 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1126211004754 signal recognition particle protein; Provisional; Region: PRK10867 1126211004755 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1126211004756 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1126211004757 P loop; other site 1126211004758 GTP binding site [chemical binding]; other site 1126211004759 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1126211004760 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1126211004761 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1126211004762 KH domain; Region: KH_4; pfam13083 1126211004763 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1126211004764 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1126211004765 RimM N-terminal domain; Region: RimM; pfam01782 1126211004766 PRC-barrel domain; Region: PRC; pfam05239 1126211004767 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1126211004768 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1126211004769 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1126211004770 GTP/Mg2+ binding site [chemical binding]; other site 1126211004771 G4 box; other site 1126211004772 G5 box; other site 1126211004773 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1126211004774 G1 box; other site 1126211004775 G1 box; other site 1126211004776 GTP/Mg2+ binding site [chemical binding]; other site 1126211004777 Switch I region; other site 1126211004778 G2 box; other site 1126211004779 G2 box; other site 1126211004780 G3 box; other site 1126211004781 G3 box; other site 1126211004782 Switch II region; other site 1126211004783 Switch II region; other site 1126211004784 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1126211004785 RNA/DNA hybrid binding site [nucleotide binding]; other site 1126211004786 active site 1126211004787 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1126211004788 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1126211004789 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1126211004790 CoA-ligase; Region: Ligase_CoA; pfam00549 1126211004791 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1126211004792 CoA binding domain; Region: CoA_binding; smart00881 1126211004793 CoA-ligase; Region: Ligase_CoA; pfam00549 1126211004794 DNA protecting protein DprA; Region: dprA; TIGR00732 1126211004795 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1126211004796 DNA topoisomerase I; Validated; Region: PRK05582 1126211004797 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1126211004798 active site 1126211004799 interdomain interaction site; other site 1126211004800 putative metal-binding site [ion binding]; other site 1126211004801 nucleotide binding site [chemical binding]; other site 1126211004802 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1126211004803 domain I; other site 1126211004804 DNA binding groove [nucleotide binding] 1126211004805 phosphate binding site [ion binding]; other site 1126211004806 domain II; other site 1126211004807 domain III; other site 1126211004808 nucleotide binding site [chemical binding]; other site 1126211004809 catalytic site [active] 1126211004810 domain IV; other site 1126211004811 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1126211004812 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1126211004813 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1126211004814 Glucose inhibited division protein A; Region: GIDA; pfam01134 1126211004815 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1126211004816 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1126211004817 active site 1126211004818 Int/Topo IB signature motif; other site 1126211004819 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1126211004820 active site 1126211004821 HslU subunit interaction site [polypeptide binding]; other site 1126211004822 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1126211004823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211004824 Walker A motif; other site 1126211004825 ATP binding site [chemical binding]; other site 1126211004826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1126211004827 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1126211004828 transcriptional repressor CodY; Validated; Region: PRK04158 1126211004829 CodY GAF-like domain; Region: CodY; pfam06018 1126211004830 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1126211004831 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1126211004832 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1126211004833 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1126211004834 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1126211004835 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 1126211004836 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1126211004837 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1126211004838 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1126211004839 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1126211004840 MgtE intracellular N domain; Region: MgtE_N; smart00924 1126211004841 FliG C-terminal domain; Region: FliG_C; pfam01706 1126211004842 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 1126211004843 Flagellar assembly protein FliH; Region: FliH; pfam02108 1126211004844 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1126211004845 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1126211004846 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1126211004847 Walker A motif/ATP binding site; other site 1126211004848 Walker B motif; other site 1126211004849 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1126211004850 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1126211004851 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1126211004852 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1126211004853 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1126211004854 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1126211004855 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1126211004856 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1126211004857 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1126211004858 Flagellar protein (FlbD); Region: FlbD; pfam06289 1126211004859 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1126211004860 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 1126211004861 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1126211004862 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1126211004863 flagellar motor switch protein; Validated; Region: PRK08119 1126211004864 CheC-like family; Region: CheC; pfam04509 1126211004865 CheC-like family; Region: CheC; pfam04509 1126211004866 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1126211004867 Response regulator receiver domain; Region: Response_reg; pfam00072 1126211004868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211004869 active site 1126211004870 phosphorylation site [posttranslational modification] 1126211004871 intermolecular recognition site; other site 1126211004872 dimerization interface [polypeptide binding]; other site 1126211004873 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 1126211004874 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1126211004875 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1126211004876 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1126211004877 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1126211004878 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1126211004879 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1126211004880 FHIPEP family; Region: FHIPEP; pfam00771 1126211004881 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1126211004882 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1126211004883 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1126211004884 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1126211004885 P-loop; other site 1126211004886 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1126211004887 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1126211004888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211004889 active site 1126211004890 phosphorylation site [posttranslational modification] 1126211004891 intermolecular recognition site; other site 1126211004892 dimerization interface [polypeptide binding]; other site 1126211004893 CheB methylesterase; Region: CheB_methylest; pfam01339 1126211004894 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1126211004895 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1126211004896 putative binding surface; other site 1126211004897 active site 1126211004898 P2 response regulator binding domain; Region: P2; pfam07194 1126211004899 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1126211004900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211004901 ATP binding site [chemical binding]; other site 1126211004902 Mg2+ binding site [ion binding]; other site 1126211004903 G-X-G motif; other site 1126211004904 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1126211004905 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1126211004906 putative CheA interaction surface; other site 1126211004907 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1126211004908 CheC-like family; Region: CheC; pfam04509 1126211004909 CheC-like family; Region: CheC; pfam04509 1126211004910 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1126211004911 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1126211004912 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1126211004913 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1126211004914 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1126211004915 DNA binding residues [nucleotide binding] 1126211004916 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1126211004917 rRNA interaction site [nucleotide binding]; other site 1126211004918 S8 interaction site; other site 1126211004919 putative laminin-1 binding site; other site 1126211004920 elongation factor Ts; Provisional; Region: tsf; PRK09377 1126211004921 UBA/TS-N domain; Region: UBA; pfam00627 1126211004922 Elongation factor TS; Region: EF_TS; pfam00889 1126211004923 Elongation factor TS; Region: EF_TS; pfam00889 1126211004924 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1126211004925 putative nucleotide binding site [chemical binding]; other site 1126211004926 uridine monophosphate binding site [chemical binding]; other site 1126211004927 homohexameric interface [polypeptide binding]; other site 1126211004928 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1126211004929 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1126211004930 hinge region; other site 1126211004931 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1126211004932 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1126211004933 catalytic residue [active] 1126211004934 putative FPP diphosphate binding site; other site 1126211004935 putative FPP binding hydrophobic cleft; other site 1126211004936 dimer interface [polypeptide binding]; other site 1126211004937 putative IPP diphosphate binding site; other site 1126211004938 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1126211004939 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1126211004940 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1126211004941 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1126211004942 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1126211004943 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1126211004944 RIP metalloprotease RseP; Region: TIGR00054 1126211004945 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1126211004946 active site 1126211004947 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1126211004948 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1126211004949 protein binding site [polypeptide binding]; other site 1126211004950 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1126211004951 putative substrate binding region [chemical binding]; other site 1126211004952 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1126211004953 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1126211004954 dimer interface [polypeptide binding]; other site 1126211004955 motif 1; other site 1126211004956 active site 1126211004957 motif 2; other site 1126211004958 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1126211004959 putative deacylase active site [active] 1126211004960 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1126211004961 active site 1126211004962 motif 3; other site 1126211004963 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1126211004964 anticodon binding site; other site 1126211004965 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1126211004966 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1126211004967 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1126211004968 generic binding surface II; other site 1126211004969 generic binding surface I; other site 1126211004970 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1126211004971 active site 1126211004972 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1126211004973 active site 1126211004974 catalytic site [active] 1126211004975 substrate binding site [chemical binding]; other site 1126211004976 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1126211004977 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1126211004978 Sm and related proteins; Region: Sm_like; cl00259 1126211004979 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1126211004980 putative oligomer interface [polypeptide binding]; other site 1126211004981 putative RNA binding site [nucleotide binding]; other site 1126211004982 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1126211004983 NusA N-terminal domain; Region: NusA_N; pfam08529 1126211004984 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1126211004985 RNA binding site [nucleotide binding]; other site 1126211004986 homodimer interface [polypeptide binding]; other site 1126211004987 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1126211004988 G-X-X-G motif; other site 1126211004989 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1126211004990 G-X-X-G motif; other site 1126211004991 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1126211004992 putative RNA binding cleft [nucleotide binding]; other site 1126211004993 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1126211004994 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1126211004995 translation initiation factor IF-2; Region: IF-2; TIGR00487 1126211004996 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1126211004997 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1126211004998 G1 box; other site 1126211004999 putative GEF interaction site [polypeptide binding]; other site 1126211005000 GTP/Mg2+ binding site [chemical binding]; other site 1126211005001 Switch I region; other site 1126211005002 G2 box; other site 1126211005003 G3 box; other site 1126211005004 Switch II region; other site 1126211005005 G4 box; other site 1126211005006 G5 box; other site 1126211005007 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1126211005008 Translation-initiation factor 2; Region: IF-2; pfam11987 1126211005009 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1126211005010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1126211005011 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1126211005012 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1126211005013 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1126211005014 RNA binding site [nucleotide binding]; other site 1126211005015 active site 1126211005016 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1126211005017 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1126211005018 active site 1126211005019 Riboflavin kinase; Region: Flavokinase; smart00904 1126211005020 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1126211005021 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1126211005022 RNase E interface [polypeptide binding]; other site 1126211005023 trimer interface [polypeptide binding]; other site 1126211005024 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1126211005025 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1126211005026 RNase E interface [polypeptide binding]; other site 1126211005027 trimer interface [polypeptide binding]; other site 1126211005028 active site 1126211005029 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1126211005030 putative nucleic acid binding region [nucleotide binding]; other site 1126211005031 G-X-X-G motif; other site 1126211005032 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1126211005033 RNA binding site [nucleotide binding]; other site 1126211005034 domain interface; other site 1126211005035 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1126211005036 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1126211005037 NodB motif; other site 1126211005038 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1126211005039 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1126211005040 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1126211005041 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1126211005042 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1126211005043 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1126211005044 NAD binding site [chemical binding]; other site 1126211005045 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1126211005046 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1126211005047 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1126211005048 aspartate kinase I; Reviewed; Region: PRK08210 1126211005049 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1126211005050 putative catalytic residues [active] 1126211005051 putative nucleotide binding site [chemical binding]; other site 1126211005052 putative aspartate binding site [chemical binding]; other site 1126211005053 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1126211005054 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1126211005055 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1126211005056 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1126211005057 dimer interface [polypeptide binding]; other site 1126211005058 active site 1126211005059 catalytic residue [active] 1126211005060 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1126211005061 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1126211005062 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1126211005063 Clp protease; Region: CLP_protease; pfam00574 1126211005064 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1126211005065 active site 1126211005066 YlzJ-like protein; Region: YlzJ; pfam14035 1126211005067 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1126211005068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211005069 DNA-binding site [nucleotide binding]; DNA binding site 1126211005070 UTRA domain; Region: UTRA; pfam07702 1126211005071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211005072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211005073 putative substrate translocation pore; other site 1126211005074 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211005075 MarR family; Region: MarR_2; pfam12802 1126211005076 MMPL family; Region: MMPL; pfam03176 1126211005077 Predicted membrane protein [Function unknown]; Region: COG1511 1126211005078 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1126211005079 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1126211005080 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1126211005081 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1126211005082 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1126211005083 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1126211005084 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1126211005085 classical (c) SDRs; Region: SDR_c; cd05233 1126211005086 NAD(P) binding site [chemical binding]; other site 1126211005087 active site 1126211005088 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1126211005089 ACT domain; Region: ACT; pfam01842 1126211005090 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1126211005091 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1126211005092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211005093 non-specific DNA binding site [nucleotide binding]; other site 1126211005094 salt bridge; other site 1126211005095 sequence-specific DNA binding site [nucleotide binding]; other site 1126211005096 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1126211005097 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1126211005098 competence damage-inducible protein A; Provisional; Region: PRK00549 1126211005099 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1126211005100 putative MPT binding site; other site 1126211005101 Competence-damaged protein; Region: CinA; pfam02464 1126211005102 recombinase A; Provisional; Region: recA; PRK09354 1126211005103 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1126211005104 hexamer interface [polypeptide binding]; other site 1126211005105 Walker A motif; other site 1126211005106 ATP binding site [chemical binding]; other site 1126211005107 Walker B motif; other site 1126211005108 Beta-lactamase; Region: Beta-lactamase; pfam00144 1126211005109 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1126211005110 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1126211005111 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1126211005112 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1126211005113 Zn2+ binding site [ion binding]; other site 1126211005114 Mg2+ binding site [ion binding]; other site 1126211005115 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1126211005116 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1126211005117 putative active site [active] 1126211005118 metal binding site [ion binding]; metal-binding site 1126211005119 homodimer binding site [polypeptide binding]; other site 1126211005120 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1126211005121 Threonine dehydrogenase; Region: TDH; cd05281 1126211005122 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1126211005123 structural Zn binding site [ion binding]; other site 1126211005124 catalytic Zn binding site [ion binding]; other site 1126211005125 tetramer interface [polypeptide binding]; other site 1126211005126 NADP binding site [chemical binding]; other site 1126211005127 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1126211005128 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1126211005129 substrate-cofactor binding pocket; other site 1126211005130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211005131 catalytic residue [active] 1126211005132 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1126211005133 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1126211005134 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1126211005135 FeS/SAM binding site; other site 1126211005136 TRAM domain; Region: TRAM; pfam01938 1126211005137 Predicted membrane protein [Function unknown]; Region: COG4550 1126211005138 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1126211005139 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1126211005140 MutS domain I; Region: MutS_I; pfam01624 1126211005141 MutS domain II; Region: MutS_II; pfam05188 1126211005142 MutS domain III; Region: MutS_III; pfam05192 1126211005143 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1126211005144 Walker A/P-loop; other site 1126211005145 ATP binding site [chemical binding]; other site 1126211005146 Q-loop/lid; other site 1126211005147 ABC transporter signature motif; other site 1126211005148 Walker B; other site 1126211005149 D-loop; other site 1126211005150 H-loop/switch region; other site 1126211005151 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1126211005152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211005153 ATP binding site [chemical binding]; other site 1126211005154 Mg2+ binding site [ion binding]; other site 1126211005155 G-X-G motif; other site 1126211005156 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1126211005157 ATP binding site [chemical binding]; other site 1126211005158 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1126211005159 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1126211005160 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1126211005161 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1126211005162 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1126211005163 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1126211005164 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1126211005165 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1126211005166 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1126211005167 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1126211005168 FMN binding site [chemical binding]; other site 1126211005169 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1126211005170 substrate binding site [chemical binding]; other site 1126211005171 putative catalytic residue [active] 1126211005172 acyl carrier protein; Validated; Region: PRK07117 1126211005173 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1126211005174 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1126211005175 dimer interface [polypeptide binding]; other site 1126211005176 active site 1126211005177 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1126211005178 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1126211005179 substrate binding site [chemical binding]; other site 1126211005180 oxyanion hole (OAH) forming residues; other site 1126211005181 trimer interface [polypeptide binding]; other site 1126211005182 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1126211005183 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1126211005184 substrate binding site [chemical binding]; other site 1126211005185 oxyanion hole (OAH) forming residues; other site 1126211005186 trimer interface [polypeptide binding]; other site 1126211005187 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211005188 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211005189 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211005190 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211005191 active site 1126211005192 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211005193 putative NADP binding site [chemical binding]; other site 1126211005194 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211005195 active site 1126211005196 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005197 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211005198 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211005199 active site 1126211005200 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211005201 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1126211005202 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211005203 active site 1126211005204 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211005205 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211005206 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211005207 putative NADP binding site [chemical binding]; other site 1126211005208 active site 1126211005209 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211005210 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211005211 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211005212 active site 1126211005213 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211005214 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211005215 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211005216 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211005217 active site 1126211005218 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211005219 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211005220 putative NADP binding site [chemical binding]; other site 1126211005221 active site 1126211005222 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005223 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211005224 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211005225 active site 1126211005226 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211005227 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005228 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211005229 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1126211005230 active site 1126211005231 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211005232 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211005233 putative NADP binding site [chemical binding]; other site 1126211005234 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211005235 active site 1126211005236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211005237 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005238 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211005239 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211005240 active site 1126211005241 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211005242 putative NADP binding site [chemical binding]; other site 1126211005243 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211005244 active site 1126211005245 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005246 Condensation domain; Region: Condensation; pfam00668 1126211005247 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005248 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211005249 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211005250 acyl-activating enzyme (AAE) consensus motif; other site 1126211005251 AMP binding site [chemical binding]; other site 1126211005252 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005253 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1126211005254 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211005255 active site 1126211005256 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211005257 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211005258 putative NADP binding site [chemical binding]; other site 1126211005259 KR domain; Region: KR; pfam08659 1126211005260 active site 1126211005261 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211005262 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1126211005263 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211005264 active site 1126211005265 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211005266 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211005267 putative NADP binding site [chemical binding]; other site 1126211005268 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211005269 active site 1126211005270 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211005271 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1126211005272 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211005273 active site 1126211005274 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211005275 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211005276 putative NADP binding site [chemical binding]; other site 1126211005277 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211005278 active site 1126211005279 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1126211005280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211005281 S-adenosylmethionine binding site [chemical binding]; other site 1126211005282 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211005283 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211005284 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211005285 active site 1126211005286 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211005287 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1126211005288 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211005289 active site 1126211005290 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005291 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1126211005292 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1126211005293 Cytochrome P450; Region: p450; cl12078 1126211005294 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1126211005295 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1126211005296 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1126211005297 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1126211005298 active site 1126211005299 catalytic triad [active] 1126211005300 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1126211005301 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1126211005302 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1126211005303 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1126211005304 YmaF family; Region: YmaF; pfam12788 1126211005305 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1126211005306 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1126211005307 bacterial Hfq-like; Region: Hfq; cd01716 1126211005308 hexamer interface [polypeptide binding]; other site 1126211005309 Sm1 motif; other site 1126211005310 RNA binding site [nucleotide binding]; other site 1126211005311 Sm2 motif; other site 1126211005312 YmzC-like protein; Region: YmzC; pfam14157 1126211005313 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1126211005314 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1126211005315 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1126211005316 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1126211005317 active site 1126211005318 dimer interface [polypeptide binding]; other site 1126211005319 catalytic residues [active] 1126211005320 effector binding site; other site 1126211005321 R2 peptide binding site; other site 1126211005322 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1126211005323 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1126211005324 dimer interface [polypeptide binding]; other site 1126211005325 putative radical transfer pathway; other site 1126211005326 diiron center [ion binding]; other site 1126211005327 tyrosyl radical; other site 1126211005328 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1126211005329 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1126211005330 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1126211005331 active site 1126211005332 metal binding site [ion binding]; metal-binding site 1126211005333 Sporulation related domain; Region: SPOR; cl10051 1126211005334 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1126211005335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211005336 Walker A motif; other site 1126211005337 ATP binding site [chemical binding]; other site 1126211005338 Walker B motif; other site 1126211005339 arginine finger; other site 1126211005340 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1126211005341 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1126211005342 HflX GTPase family; Region: HflX; cd01878 1126211005343 G1 box; other site 1126211005344 GTP/Mg2+ binding site [chemical binding]; other site 1126211005345 Switch I region; other site 1126211005346 G2 box; other site 1126211005347 G3 box; other site 1126211005348 Switch II region; other site 1126211005349 G4 box; other site 1126211005350 G5 box; other site 1126211005351 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1126211005352 Aluminium resistance protein; Region: Alum_res; pfam06838 1126211005353 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1126211005354 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1126211005355 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1126211005356 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1126211005357 Int/Topo IB signature motif; other site 1126211005358 Staphylococcal nuclease homologues; Region: SNc; smart00318 1126211005359 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1126211005360 Catalytic site; other site 1126211005361 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1126211005362 YolD-like protein; Region: YolD; pfam08863 1126211005363 DNA polymerase IV; Reviewed; Region: PRK03103 1126211005364 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1126211005365 active site 1126211005366 DNA binding site [nucleotide binding] 1126211005367 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1126211005368 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211005369 TPR motif; other site 1126211005370 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211005371 binding surface 1126211005372 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1126211005373 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1126211005374 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1126211005375 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1126211005376 Phage-related protein [Function unknown]; Region: COG4722 1126211005377 Phage tail protein; Region: Sipho_tail; cl17486 1126211005378 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1126211005379 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1126211005380 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1126211005381 active site 1126211005382 catalytic residues [active] 1126211005383 DNA binding site [nucleotide binding] 1126211005384 Int/Topo IB signature motif; other site 1126211005385 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1126211005386 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1126211005387 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1126211005388 IHF dimer interface [polypeptide binding]; other site 1126211005389 IHF - DNA interface [nucleotide binding]; other site 1126211005390 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1126211005391 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 1126211005392 nucleotide binding site [chemical binding]; other site 1126211005393 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 1126211005394 GIY-YIG motif/motif A; other site 1126211005395 putative active site [active] 1126211005396 catalytic site [active] 1126211005397 putative metal binding site [ion binding]; other site 1126211005398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211005399 S-adenosylmethionine binding site [chemical binding]; other site 1126211005400 Methyltransferase domain; Region: Methyltransf_27; pfam13708 1126211005401 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1126211005402 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1126211005403 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1126211005404 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1126211005405 active site 1126211005406 catalytic residues [active] 1126211005407 DNA binding site [nucleotide binding] 1126211005408 Int/Topo IB signature motif; other site 1126211005409 DNA-sulfur modification-associated; Region: DndB; cl17621 1126211005410 DGQHR domain; Region: DGQHR; TIGR03187 1126211005411 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 1126211005412 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1126211005413 active site 1126211005414 DNA binding site [nucleotide binding] 1126211005415 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1126211005416 YopX protein; Region: YopX; pfam09643 1126211005417 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1126211005418 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1126211005419 Right handed beta helix region; Region: Beta_helix; pfam13229 1126211005420 Right handed beta helix region; Region: Beta_helix; pfam13229 1126211005421 AAA domain; Region: AAA_24; pfam13479 1126211005422 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 1126211005423 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1126211005424 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1126211005425 ATP binding site [chemical binding]; other site 1126211005426 Walker B motif; other site 1126211005427 hypothetical protein; Provisional; Region: PRK08624 1126211005428 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1126211005429 active site 1126211005430 metal binding site [ion binding]; metal-binding site 1126211005431 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1126211005432 DHH family; Region: DHH; pfam01368 1126211005433 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 1126211005434 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1126211005435 active site 1126211005436 3D domain; Region: 3D; cl01439 1126211005437 YorP protein; Region: YorP; pfam09629 1126211005438 ribulose-bisphosphate carboxylase small chain; Region: PLN02289 1126211005439 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1126211005440 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1126211005441 active site 1126211005442 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1126211005443 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 1126211005444 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1126211005445 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1126211005446 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1126211005447 active site 1126211005448 dimer interface [polypeptide binding]; other site 1126211005449 catalytic residues [active] 1126211005450 effector binding site; other site 1126211005451 R2 peptide binding site; other site 1126211005452 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1126211005453 dimer interface [polypeptide binding]; other site 1126211005454 putative radical transfer pathway; other site 1126211005455 diiron center [ion binding]; other site 1126211005456 tyrosyl radical; other site 1126211005457 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1126211005458 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1126211005459 trimer interface [polypeptide binding]; other site 1126211005460 active site 1126211005461 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1126211005462 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1126211005463 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1126211005464 dimerization interface [polypeptide binding]; other site 1126211005465 active site 1126211005466 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1126211005467 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1126211005468 folate binding site [chemical binding]; other site 1126211005469 NADP+ binding site [chemical binding]; other site 1126211005470 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1126211005471 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1126211005472 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1126211005473 active site 1126211005474 metal binding site [ion binding]; metal-binding site 1126211005475 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1126211005476 Penicillin-binding protein-related factor A, putative recombinase [General function prediction only]; Region: PrfA; COG3331 1126211005477 Major royal jelly protein; Region: MRJP; pfam03022 1126211005478 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1126211005479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211005480 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1126211005481 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1126211005482 inhibitor binding site; inhibition site 1126211005483 active site 1126211005484 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1126211005485 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1126211005486 non-specific DNA interactions [nucleotide binding]; other site 1126211005487 DNA binding site [nucleotide binding] 1126211005488 sequence specific DNA binding site [nucleotide binding]; other site 1126211005489 putative cAMP binding site [chemical binding]; other site 1126211005490 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1126211005491 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1126211005492 nucleotide binding site [chemical binding]; other site 1126211005493 xylose isomerase; Provisional; Region: PRK05474 1126211005494 xylose isomerase; Region: xylose_isom_A; TIGR02630 1126211005495 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1126211005496 N- and C-terminal domain interface [polypeptide binding]; other site 1126211005497 D-xylulose kinase; Region: XylB; TIGR01312 1126211005498 active site 1126211005499 MgATP binding site [chemical binding]; other site 1126211005500 catalytic site [active] 1126211005501 metal binding site [ion binding]; metal-binding site 1126211005502 xylulose binding site [chemical binding]; other site 1126211005503 homodimer interface [polypeptide binding]; other site 1126211005504 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1126211005505 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1126211005506 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1126211005507 Predicted transcriptional regulator [Transcription]; Region: COG2378 1126211005508 HTH domain; Region: HTH_11; pfam08279 1126211005509 WYL domain; Region: WYL; pfam13280 1126211005510 DinB family; Region: DinB; cl17821 1126211005511 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1126211005512 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1126211005513 NAD binding site [chemical binding]; other site 1126211005514 substrate binding site [chemical binding]; other site 1126211005515 catalytic Zn binding site [ion binding]; other site 1126211005516 tetramer interface [polypeptide binding]; other site 1126211005517 structural Zn binding site [ion binding]; other site 1126211005518 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1126211005519 Coenzyme A binding pocket [chemical binding]; other site 1126211005520 YoaP-like; Region: YoaP; pfam14268 1126211005521 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1126211005522 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1126211005523 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1126211005524 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211005525 Coenzyme A binding pocket [chemical binding]; other site 1126211005526 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1126211005527 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1126211005528 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1126211005529 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1126211005530 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1126211005531 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1126211005532 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1126211005533 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1126211005534 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1126211005535 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1126211005536 trimer interface [polypeptide binding]; other site 1126211005537 active site 1126211005538 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1126211005539 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 1126211005540 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1126211005541 LexA repressor; Validated; Region: PRK00215 1126211005542 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1126211005543 putative DNA binding site [nucleotide binding]; other site 1126211005544 putative Zn2+ binding site [ion binding]; other site 1126211005545 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1126211005546 Catalytic site [active] 1126211005547 cell division suppressor protein YneA; Provisional; Region: PRK14125 1126211005548 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211005549 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1126211005550 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1126211005551 catalytic residues [active] 1126211005552 catalytic nucleophile [active] 1126211005553 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1126211005554 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1126211005555 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1126211005556 TPP-binding site [chemical binding]; other site 1126211005557 dimer interface [polypeptide binding]; other site 1126211005558 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1126211005559 PYR/PP interface [polypeptide binding]; other site 1126211005560 dimer interface [polypeptide binding]; other site 1126211005561 TPP binding site [chemical binding]; other site 1126211005562 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1126211005563 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1126211005564 hypothetical protein; Provisional; Region: PRK01844 1126211005565 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1126211005566 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1126211005567 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1126211005568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211005569 active site 1126211005570 phosphorylation site [posttranslational modification] 1126211005571 intermolecular recognition site; other site 1126211005572 dimerization interface [polypeptide binding]; other site 1126211005573 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1126211005574 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1126211005575 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1126211005576 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1126211005577 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 1126211005578 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1126211005579 aconitate hydratase; Validated; Region: PRK09277 1126211005580 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1126211005581 substrate binding site [chemical binding]; other site 1126211005582 ligand binding site [chemical binding]; other site 1126211005583 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1126211005584 substrate binding site [chemical binding]; other site 1126211005585 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1126211005586 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1126211005587 catalytic residues [active] 1126211005588 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1126211005589 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1126211005590 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1126211005591 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1126211005592 active site 1126211005593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1126211005594 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1126211005595 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1126211005596 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1126211005597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211005598 ATP binding site [chemical binding]; other site 1126211005599 Mg2+ binding site [ion binding]; other site 1126211005600 G-X-G motif; other site 1126211005601 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1126211005602 anchoring element; other site 1126211005603 dimer interface [polypeptide binding]; other site 1126211005604 ATP binding site [chemical binding]; other site 1126211005605 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1126211005606 active site 1126211005607 metal binding site [ion binding]; metal-binding site 1126211005608 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1126211005609 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1126211005610 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1126211005611 CAP-like domain; other site 1126211005612 active site 1126211005613 primary dimer interface [polypeptide binding]; other site 1126211005614 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1126211005615 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1126211005616 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1126211005617 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1126211005618 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1126211005619 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1126211005620 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1126211005621 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1126211005622 substrate binding site [chemical binding]; other site 1126211005623 ATP binding site [chemical binding]; other site 1126211005624 putative oxidoreductase; Provisional; Region: PRK10083 1126211005625 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1126211005626 putative NAD(P) binding site [chemical binding]; other site 1126211005627 catalytic Zn binding site [ion binding]; other site 1126211005628 structural Zn binding site [ion binding]; other site 1126211005629 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1126211005630 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1126211005631 active site 1126211005632 intersubunit interface [polypeptide binding]; other site 1126211005633 catalytic residue [active] 1126211005634 mannonate dehydratase; Region: uxuA; TIGR00695 1126211005635 mannonate dehydratase; Provisional; Region: PRK03906 1126211005636 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1126211005637 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1126211005638 putative NAD(P) binding site [chemical binding]; other site 1126211005639 active site 1126211005640 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1126211005641 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1126211005642 DNA binding site [nucleotide binding] 1126211005643 domain linker motif; other site 1126211005644 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1126211005645 putative dimerization interface [polypeptide binding]; other site 1126211005646 putative ligand binding site [chemical binding]; other site 1126211005647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211005648 D-galactonate transporter; Region: 2A0114; TIGR00893 1126211005649 putative substrate translocation pore; other site 1126211005650 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1126211005651 YndJ-like protein; Region: YndJ; pfam14158 1126211005652 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1126211005653 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1126211005654 Cellulose binding domain; Region: CBM_3; pfam00942 1126211005655 Tic20-like protein; Region: Tic20; pfam09685 1126211005656 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211005657 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1126211005658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211005659 dimer interface [polypeptide binding]; other site 1126211005660 phosphorylation site [posttranslational modification] 1126211005661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211005662 ATP binding site [chemical binding]; other site 1126211005663 Mg2+ binding site [ion binding]; other site 1126211005664 G-X-G motif; other site 1126211005665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211005666 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211005667 active site 1126211005668 phosphorylation site [posttranslational modification] 1126211005669 intermolecular recognition site; other site 1126211005670 dimerization interface [polypeptide binding]; other site 1126211005671 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211005672 DNA binding site [nucleotide binding] 1126211005673 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1126211005674 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1126211005675 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1126211005676 substrate binding site [chemical binding]; other site 1126211005677 active site 1126211005678 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1126211005679 metal binding site [ion binding]; metal-binding site 1126211005680 ligand binding site [chemical binding]; other site 1126211005681 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211005682 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1126211005683 acyl-activating enzyme (AAE) consensus motif; other site 1126211005684 AMP binding site [chemical binding]; other site 1126211005685 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005686 Condensation domain; Region: Condensation; pfam00668 1126211005687 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005688 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1126211005689 Condensation domain; Region: Condensation; pfam00668 1126211005690 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005691 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211005692 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211005693 acyl-activating enzyme (AAE) consensus motif; other site 1126211005694 AMP binding site [chemical binding]; other site 1126211005695 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005696 Thioesterase domain; Region: Thioesterase; pfam00975 1126211005697 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005698 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211005699 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211005700 acyl-activating enzyme (AAE) consensus motif; other site 1126211005701 AMP binding site [chemical binding]; other site 1126211005702 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005703 Condensation domain; Region: Condensation; pfam00668 1126211005704 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005705 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1126211005706 Condensation domain; Region: Condensation; pfam00668 1126211005707 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005708 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211005709 acyl-activating enzyme (AAE) consensus motif; other site 1126211005710 AMP binding site [chemical binding]; other site 1126211005711 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005712 Condensation domain; Region: Condensation; pfam00668 1126211005713 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005714 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1126211005715 Condensation domain; Region: Condensation; pfam00668 1126211005716 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005717 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211005718 acyl-activating enzyme (AAE) consensus motif; other site 1126211005719 AMP binding site [chemical binding]; other site 1126211005720 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005721 Condensation domain; Region: Condensation; pfam00668 1126211005722 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005723 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211005724 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211005725 acyl-activating enzyme (AAE) consensus motif; other site 1126211005726 AMP binding site [chemical binding]; other site 1126211005727 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005728 Condensation domain; Region: Condensation; pfam00668 1126211005729 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005730 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211005731 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1126211005732 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 1126211005733 acyl-activating enzyme (AAE) consensus motif; other site 1126211005734 putative AMP binding site [chemical binding]; other site 1126211005735 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005736 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211005737 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211005738 active site 1126211005739 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005740 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1126211005741 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1126211005742 inhibitor-cofactor binding pocket; inhibition site 1126211005743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211005744 catalytic residue [active] 1126211005745 Condensation domain; Region: Condensation; pfam00668 1126211005746 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005747 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211005748 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005749 Condensation domain; Region: Condensation; pfam00668 1126211005750 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005751 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211005752 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211005753 acyl-activating enzyme (AAE) consensus motif; other site 1126211005754 AMP binding site [chemical binding]; other site 1126211005755 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005756 Condensation domain; Region: Condensation; pfam00668 1126211005757 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005758 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211005759 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1126211005760 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1126211005761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1126211005762 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1126211005763 NAD(P) binding site [chemical binding]; other site 1126211005764 active site 1126211005765 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1126211005766 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1126211005767 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1126211005768 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1126211005769 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1126211005770 Cytochrome P450; Region: p450; cl12078 1126211005771 biotin synthase; Validated; Region: PRK06256 1126211005772 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1126211005773 FeS/SAM binding site; other site 1126211005774 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1126211005775 AAA domain; Region: AAA_26; pfam13500 1126211005776 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1126211005777 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1126211005778 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1126211005779 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1126211005780 substrate-cofactor binding pocket; other site 1126211005781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211005782 catalytic residue [active] 1126211005783 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1126211005784 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1126211005785 inhibitor-cofactor binding pocket; inhibition site 1126211005786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211005787 catalytic residue [active] 1126211005788 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 1126211005789 Predicted membrane protein [Function unknown]; Region: COG2246 1126211005790 GtrA-like protein; Region: GtrA; pfam04138 1126211005791 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1126211005792 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1126211005793 active site 1126211005794 tetramer interface; other site 1126211005795 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1126211005796 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1126211005797 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1126211005798 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1126211005799 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1126211005800 enoyl-CoA hydratase; Provisional; Region: PRK07657 1126211005801 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1126211005802 substrate binding site [chemical binding]; other site 1126211005803 oxyanion hole (OAH) forming residues; other site 1126211005804 trimer interface [polypeptide binding]; other site 1126211005805 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1126211005806 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1126211005807 active site 1126211005808 catalytic residues [active] 1126211005809 metal binding site [ion binding]; metal-binding site 1126211005810 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1126211005811 carboxyltransferase (CT) interaction site; other site 1126211005812 biotinylation site [posttranslational modification]; other site 1126211005813 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1126211005814 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1126211005815 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1126211005816 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1126211005817 AMP-binding domain protein; Validated; Region: PRK08315 1126211005818 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1126211005819 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1126211005820 acyl-activating enzyme (AAE) consensus motif; other site 1126211005821 putative AMP binding site [chemical binding]; other site 1126211005822 putative active site [active] 1126211005823 putative CoA binding site [chemical binding]; other site 1126211005824 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1126211005825 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1126211005826 FAD binding site [chemical binding]; other site 1126211005827 homotetramer interface [polypeptide binding]; other site 1126211005828 substrate binding pocket [chemical binding]; other site 1126211005829 catalytic base [active] 1126211005830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1126211005831 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1126211005832 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1126211005833 Condensation domain; Region: Condensation; pfam00668 1126211005834 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005835 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1126211005836 acyl-activating enzyme (AAE) consensus motif; other site 1126211005837 AMP binding site [chemical binding]; other site 1126211005838 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005839 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1126211005840 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211005841 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211005842 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1126211005843 acyl-activating enzyme (AAE) consensus motif; other site 1126211005844 AMP binding site [chemical binding]; other site 1126211005845 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005846 Condensation domain; Region: Condensation; pfam00668 1126211005847 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1126211005848 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211005849 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1126211005850 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1126211005851 acyl-activating enzyme (AAE) consensus motif; other site 1126211005852 AMP binding site [chemical binding]; other site 1126211005853 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005854 Condensation domain; Region: Condensation; pfam00668 1126211005855 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1126211005856 Condensation domain; Region: Condensation; pfam00668 1126211005857 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005858 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211005859 acyl-activating enzyme (AAE) consensus motif; other site 1126211005860 AMP binding site [chemical binding]; other site 1126211005861 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005862 Condensation domain; Region: Condensation; pfam00668 1126211005863 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211005864 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211005865 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1126211005866 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211005867 acyl-activating enzyme (AAE) consensus motif; other site 1126211005868 AMP binding site [chemical binding]; other site 1126211005869 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211005870 Condensation domain; Region: Condensation; pfam00668 1126211005871 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1126211005872 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1126211005873 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1126211005874 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1126211005875 active site 1126211005876 catalytic residues [active] 1126211005877 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1126211005878 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1126211005879 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1126211005880 Int/Topo IB signature motif; other site 1126211005881 Helix-turn-helix domain; Region: HTH_17; cl17695 1126211005882 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1126211005883 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1126211005884 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1126211005885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211005886 putative substrate translocation pore; other site 1126211005887 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1126211005888 dimerization interface [polypeptide binding]; other site 1126211005889 putative DNA binding site [nucleotide binding]; other site 1126211005890 putative Zn2+ binding site [ion binding]; other site 1126211005891 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1126211005892 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1126211005893 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1126211005894 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1126211005895 active site 1126211005896 dimer interface [polypeptide binding]; other site 1126211005897 motif 1; other site 1126211005898 motif 2; other site 1126211005899 motif 3; other site 1126211005900 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1126211005901 anticodon binding site; other site 1126211005902 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1126211005903 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1126211005904 NAD(P) binding site [chemical binding]; other site 1126211005905 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1126211005906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1126211005907 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1126211005908 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1126211005909 active site 1126211005910 dimer interface [polypeptide binding]; other site 1126211005911 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1126211005912 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1126211005913 active site 1126211005914 FMN binding site [chemical binding]; other site 1126211005915 substrate binding site [chemical binding]; other site 1126211005916 3Fe-4S cluster binding site [ion binding]; other site 1126211005917 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1126211005918 domain interface; other site 1126211005919 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1126211005920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1126211005921 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1126211005922 putative dimerization interface [polypeptide binding]; other site 1126211005923 gamma-glutamyl kinase; Provisional; Region: PRK13402 1126211005924 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1126211005925 nucleotide binding site [chemical binding]; other site 1126211005926 homotetrameric interface [polypeptide binding]; other site 1126211005927 putative phosphate binding site [ion binding]; other site 1126211005928 putative allosteric binding site; other site 1126211005929 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1126211005930 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1126211005931 Replication terminator protein; Region: RTP; pfam02334 1126211005932 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1126211005933 classical (c) SDRs; Region: SDR_c; cd05233 1126211005934 NAD(P) binding site [chemical binding]; other site 1126211005935 active site 1126211005936 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1126211005937 polyol permease family; Region: 2A0118; TIGR00897 1126211005938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211005939 putative substrate translocation pore; other site 1126211005940 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1126211005941 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1126211005942 nucleotide binding site [chemical binding]; other site 1126211005943 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1126211005944 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1126211005945 putative ligand binding site [chemical binding]; other site 1126211005946 putative NAD binding site [chemical binding]; other site 1126211005947 catalytic site [active] 1126211005948 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1126211005949 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1126211005950 putative molybdopterin cofactor binding site [chemical binding]; other site 1126211005951 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1126211005952 putative molybdopterin cofactor binding site; other site 1126211005953 MarR family; Region: MarR_2; pfam12802 1126211005954 MarR family; Region: MarR_2; cl17246 1126211005955 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1126211005956 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1126211005957 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1126211005958 dimer interface [polypeptide binding]; other site 1126211005959 putative tRNA-binding site [nucleotide binding]; other site 1126211005960 Cupin domain; Region: Cupin_2; pfam07883 1126211005961 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1126211005962 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1126211005963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1126211005964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211005965 WHG domain; Region: WHG; pfam13305 1126211005966 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1126211005967 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1126211005968 dimerization interface [polypeptide binding]; other site 1126211005969 putative DNA binding site [nucleotide binding]; other site 1126211005970 putative Zn2+ binding site [ion binding]; other site 1126211005971 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1126211005972 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1126211005973 catalytic residue [active] 1126211005974 Predicted membrane protein [Function unknown]; Region: COG2322 1126211005975 Protein required for attachment to host cells; Region: Host_attach; cl02398 1126211005976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1126211005977 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1126211005978 putative dimer interface [polypeptide binding]; other site 1126211005979 catalytic triad [active] 1126211005980 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211005981 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211005982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1126211005983 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1126211005984 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1126211005985 ATP binding site [chemical binding]; other site 1126211005986 putative Mg++ binding site [ion binding]; other site 1126211005987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211005988 nucleotide binding region [chemical binding]; other site 1126211005989 ATP-binding site [chemical binding]; other site 1126211005990 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1126211005991 HRDC domain; Region: HRDC; pfam00570 1126211005992 azoreductase; Provisional; Region: PRK13556 1126211005993 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1126211005994 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1126211005995 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1126211005996 putative dimer interface [polypeptide binding]; other site 1126211005997 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1126211005998 pentamer interface [polypeptide binding]; other site 1126211005999 dodecaamer interface [polypeptide binding]; other site 1126211006000 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1126211006001 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1126211006002 NAD(P) binding site [chemical binding]; other site 1126211006003 catalytic residues [active] 1126211006004 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1126211006005 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1126211006006 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1126211006007 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1126211006008 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1126211006009 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1126211006010 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1126211006011 Na2 binding site [ion binding]; other site 1126211006012 putative substrate binding site 1 [chemical binding]; other site 1126211006013 Na binding site 1 [ion binding]; other site 1126211006014 putative substrate binding site 2 [chemical binding]; other site 1126211006015 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1126211006016 Sodium Bile acid symporter family; Region: SBF; pfam01758 1126211006017 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1126211006018 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1126211006019 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1126211006020 E3 interaction surface; other site 1126211006021 lipoyl attachment site [posttranslational modification]; other site 1126211006022 e3 binding domain; Region: E3_binding; pfam02817 1126211006023 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1126211006024 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1126211006025 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1126211006026 TPP-binding site [chemical binding]; other site 1126211006027 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1126211006028 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1126211006029 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1126211006030 metal ion-dependent adhesion site (MIDAS); other site 1126211006031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211006032 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1126211006033 Walker A motif; other site 1126211006034 ATP binding site [chemical binding]; other site 1126211006035 Walker B motif; other site 1126211006036 arginine finger; other site 1126211006037 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1126211006038 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1126211006039 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1126211006040 E-class dimer interface [polypeptide binding]; other site 1126211006041 P-class dimer interface [polypeptide binding]; other site 1126211006042 active site 1126211006043 Cu2+ binding site [ion binding]; other site 1126211006044 Zn2+ binding site [ion binding]; other site 1126211006045 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211006046 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1126211006047 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211006048 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1126211006049 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211006050 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1126211006051 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211006052 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1126211006053 NlpC/P60 family; Region: NLPC_P60; pfam00877 1126211006054 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1126211006055 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1126211006056 active site 1126211006057 TDP-binding site; other site 1126211006058 acceptor substrate-binding pocket; other site 1126211006059 homodimer interface [polypeptide binding]; other site 1126211006060 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1126211006061 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1126211006062 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1126211006063 multidrug efflux protein; Reviewed; Region: PRK01766 1126211006064 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1126211006065 cation binding site [ion binding]; other site 1126211006066 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1126211006067 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1126211006068 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1126211006069 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1126211006070 EamA-like transporter family; Region: EamA; pfam00892 1126211006071 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1126211006072 Predicted transcriptional regulators [Transcription]; Region: COG1733 1126211006073 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1126211006074 dimerization interface [polypeptide binding]; other site 1126211006075 putative DNA binding site [nucleotide binding]; other site 1126211006076 putative Zn2+ binding site [ion binding]; other site 1126211006077 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1126211006078 dimer interface [polypeptide binding]; other site 1126211006079 FMN binding site [chemical binding]; other site 1126211006080 Predicted esterase [General function prediction only]; Region: COG0400 1126211006081 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1126211006082 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1126211006083 Zn binding site [ion binding]; other site 1126211006084 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1126211006085 Zn binding site [ion binding]; other site 1126211006086 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1126211006087 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1126211006088 Na binding site [ion binding]; other site 1126211006089 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1126211006090 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1126211006091 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1126211006092 beta-galactosidase; Region: BGL; TIGR03356 1126211006093 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1126211006094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211006095 DNA-binding site [nucleotide binding]; DNA binding site 1126211006096 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1126211006097 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1126211006098 C-terminal peptidase (prc); Region: prc; TIGR00225 1126211006099 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1126211006100 protein binding site [polypeptide binding]; other site 1126211006101 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1126211006102 Catalytic dyad [active] 1126211006103 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1126211006104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211006105 S-adenosylmethionine binding site [chemical binding]; other site 1126211006106 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1126211006107 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1126211006108 YodL-like; Region: YodL; pfam14191 1126211006109 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1126211006110 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1126211006111 active site 1126211006112 YozD-like protein; Region: YozD; pfam14162 1126211006113 hypothetical protein; Provisional; Region: PRK13672 1126211006114 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1126211006115 toxin interface [polypeptide binding]; other site 1126211006116 Zn binding site [ion binding]; other site 1126211006117 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1126211006118 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1126211006119 FeS/SAM binding site; other site 1126211006120 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1126211006121 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1126211006122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211006123 Coenzyme A binding pocket [chemical binding]; other site 1126211006124 acetylornithine deacetylase; Validated; Region: PRK06915 1126211006125 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1126211006126 metal binding site [ion binding]; metal-binding site 1126211006127 dimer interface [polypeptide binding]; other site 1126211006128 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1126211006129 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1126211006130 hypothetical protein; Provisional; Region: PRK06917 1126211006131 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1126211006132 inhibitor-cofactor binding pocket; inhibition site 1126211006133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211006134 catalytic residue [active] 1126211006135 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1126211006136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211006137 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1126211006138 Coenzyme A binding pocket [chemical binding]; other site 1126211006139 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1126211006140 active site 1126211006141 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1126211006142 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1126211006143 Phytase; Region: Phytase; cl17685 1126211006144 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1126211006145 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1126211006146 NAD(P) binding site [chemical binding]; other site 1126211006147 homodimer interface [polypeptide binding]; other site 1126211006148 substrate binding site [chemical binding]; other site 1126211006149 active site 1126211006150 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1126211006151 SelR domain; Region: SelR; pfam01641 1126211006152 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1126211006153 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1126211006154 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1126211006155 active site 1126211006156 catalytic triad [active] 1126211006157 oxyanion hole [active] 1126211006158 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1126211006159 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1126211006160 Cu(I) binding site [ion binding]; other site 1126211006161 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1126211006162 threonine dehydratase; Validated; Region: PRK08639 1126211006163 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1126211006164 tetramer interface [polypeptide binding]; other site 1126211006165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211006166 catalytic residue [active] 1126211006167 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1126211006168 putative Ile/Val binding site [chemical binding]; other site 1126211006169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211006170 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1126211006171 Walker A motif; other site 1126211006172 ATP binding site [chemical binding]; other site 1126211006173 Walker B motif; other site 1126211006174 arginine finger; other site 1126211006175 Haemolysin-III related; Region: HlyIII; cl03831 1126211006176 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1126211006177 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1126211006178 putative acyl-acceptor binding pocket; other site 1126211006179 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1126211006180 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1126211006181 folate binding site [chemical binding]; other site 1126211006182 NADP+ binding site [chemical binding]; other site 1126211006183 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1126211006184 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1126211006185 dimerization interface [polypeptide binding]; other site 1126211006186 active site 1126211006187 YpjP-like protein; Region: YpjP; pfam14005 1126211006188 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1126211006189 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1126211006190 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1126211006191 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1126211006192 Virulence factor; Region: Virulence_fact; pfam13769 1126211006193 HEAT repeats; Region: HEAT_2; pfam13646 1126211006194 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1126211006195 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1126211006196 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1126211006197 Zn2+ binding site [ion binding]; other site 1126211006198 Mg2+ binding site [ion binding]; other site 1126211006199 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1126211006200 catalytic residues [active] 1126211006201 dimer interface [polypeptide binding]; other site 1126211006202 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1126211006203 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1126211006204 proposed active site lysine [active] 1126211006205 conserved cys residue [active] 1126211006206 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1126211006207 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1126211006208 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1126211006209 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1126211006210 DNA-binding site [nucleotide binding]; DNA binding site 1126211006211 RNA-binding motif; other site 1126211006212 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1126211006213 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1126211006214 hypothetical protein; Validated; Region: PRK07708 1126211006215 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1126211006216 RNA/DNA hybrid binding site [nucleotide binding]; other site 1126211006217 active site 1126211006218 conserved hypothetical integral membrane protein; Region: TIGR00697 1126211006219 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1126211006220 RNA/DNA hybrid binding site [nucleotide binding]; other site 1126211006221 active site 1126211006222 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1126211006223 5'-3' exonuclease; Region: 53EXOc; smart00475 1126211006224 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1126211006225 active site 1126211006226 metal binding site 1 [ion binding]; metal-binding site 1126211006227 putative 5' ssDNA interaction site; other site 1126211006228 metal binding site 3; metal-binding site 1126211006229 metal binding site 2 [ion binding]; metal-binding site 1126211006230 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1126211006231 putative DNA binding site [nucleotide binding]; other site 1126211006232 putative metal binding site [ion binding]; other site 1126211006233 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1126211006234 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1126211006235 Dynamin family; Region: Dynamin_N; pfam00350 1126211006236 G1 box; other site 1126211006237 GTP/Mg2+ binding site [chemical binding]; other site 1126211006238 G2 box; other site 1126211006239 Switch I region; other site 1126211006240 G3 box; other site 1126211006241 Switch II region; other site 1126211006242 G4 box; other site 1126211006243 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1126211006244 G1 box; other site 1126211006245 GTP/Mg2+ binding site [chemical binding]; other site 1126211006246 Dynamin family; Region: Dynamin_N; pfam00350 1126211006247 G2 box; other site 1126211006248 Switch I region; other site 1126211006249 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1126211006250 G3 box; other site 1126211006251 Switch II region; other site 1126211006252 GTP/Mg2+ binding site [chemical binding]; other site 1126211006253 G4 box; other site 1126211006254 G5 box; other site 1126211006255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1126211006256 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1126211006257 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1126211006258 malonyl-CoA binding site [chemical binding]; other site 1126211006259 dimer interface [polypeptide binding]; other site 1126211006260 active site 1126211006261 product binding site; other site 1126211006262 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1126211006263 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1126211006264 DNA binding site [nucleotide binding] 1126211006265 active site 1126211006266 Isochorismatase family; Region: Isochorismatase; pfam00857 1126211006267 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1126211006268 catalytic triad [active] 1126211006269 conserved cis-peptide bond; other site 1126211006270 Helix-turn-helix domain; Region: HTH_17; pfam12728 1126211006271 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1126211006272 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1126211006273 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1126211006274 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1126211006275 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1126211006276 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1126211006277 amidase catalytic site [active] 1126211006278 Zn binding residues [ion binding]; other site 1126211006279 substrate binding site [chemical binding]; other site 1126211006280 Bacterial SH3 domain; Region: SH3_3; cl17532 1126211006281 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1126211006282 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1126211006283 Holin family; Region: Phage_holin_4; cl01989 1126211006284 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1126211006285 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1126211006286 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1126211006287 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1126211006288 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1126211006289 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1126211006290 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1126211006291 Phage tail protein; Region: Sipho_tail; pfam05709 1126211006292 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1126211006293 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1126211006294 catalytic residue [active] 1126211006295 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1126211006296 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1126211006297 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1126211006298 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1126211006299 oligomerization interface [polypeptide binding]; other site 1126211006300 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1126211006301 Phage capsid family; Region: Phage_capsid; pfam05065 1126211006302 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1126211006303 Phage-related protein [Function unknown]; Region: COG4695 1126211006304 Phage portal protein; Region: Phage_portal; pfam04860 1126211006305 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1126211006306 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1126211006307 Helix-turn-helix domain; Region: HTH_17; pfam12728 1126211006308 positive control sigma-like factor; Validated; Region: PRK06930 1126211006309 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1126211006310 DNA binding residues [nucleotide binding] 1126211006311 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 1126211006312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211006313 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1126211006314 Walker A motif; other site 1126211006315 ATP binding site [chemical binding]; other site 1126211006316 Walker B motif; other site 1126211006317 arginine finger; other site 1126211006318 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1126211006319 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 1126211006320 Hypothetical protein Yqai; Region: Yqai; pfam09466 1126211006321 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1126211006322 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1126211006323 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1126211006324 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1126211006325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211006326 sequence-specific DNA binding site [nucleotide binding]; other site 1126211006327 salt bridge; other site 1126211006328 transcriptional repressor DicA; Reviewed; Region: PRK09706 1126211006329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211006330 non-specific DNA binding site [nucleotide binding]; other site 1126211006331 salt bridge; other site 1126211006332 sequence-specific DNA binding site [nucleotide binding]; other site 1126211006333 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1126211006334 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1126211006335 Int/Topo IB signature motif; other site 1126211006336 xanthine permease; Region: pbuX; TIGR03173 1126211006337 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1126211006338 active site 1126211006339 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1126211006340 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1126211006341 active site 1126211006342 Zn binding site [ion binding]; other site 1126211006343 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1126211006344 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1126211006345 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1126211006346 YpzG-like protein; Region: YpzG; pfam14139 1126211006347 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1126211006348 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1126211006349 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1126211006350 cell division protein GpsB; Provisional; Region: PRK14127 1126211006351 DivIVA domain; Region: DivI1A_domain; TIGR03544 1126211006352 hypothetical protein; Provisional; Region: PRK13660 1126211006353 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1126211006354 RNase_H superfamily; Region: RNase_H_2; pfam13482 1126211006355 active site 1126211006356 substrate binding site [chemical binding]; other site 1126211006357 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1126211006358 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1126211006359 ATP binding site [chemical binding]; other site 1126211006360 putative Mg++ binding site [ion binding]; other site 1126211006361 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211006362 nucleotide binding region [chemical binding]; other site 1126211006363 ATP-binding site [chemical binding]; other site 1126211006364 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1126211006365 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1126211006366 HPr interaction site; other site 1126211006367 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1126211006368 active site 1126211006369 phosphorylation site [posttranslational modification] 1126211006370 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1126211006371 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1126211006372 YppG-like protein; Region: YppG; pfam14179 1126211006373 YppF-like protein; Region: YppF; pfam14178 1126211006374 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1126211006375 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1126211006376 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1126211006377 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1126211006378 Transglycosylase; Region: Transgly; pfam00912 1126211006379 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1126211006380 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1126211006381 Interdomain contacts; other site 1126211006382 Cytokine receptor motif; other site 1126211006383 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1126211006384 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1126211006385 minor groove reading motif; other site 1126211006386 helix-hairpin-helix signature motif; other site 1126211006387 substrate binding pocket [chemical binding]; other site 1126211006388 active site 1126211006389 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1126211006390 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1126211006391 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1126211006392 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1126211006393 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1126211006394 putative dimer interface [polypeptide binding]; other site 1126211006395 putative anticodon binding site; other site 1126211006396 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1126211006397 homodimer interface [polypeptide binding]; other site 1126211006398 motif 1; other site 1126211006399 motif 2; other site 1126211006400 active site 1126211006401 motif 3; other site 1126211006402 aspartate aminotransferase; Provisional; Region: PRK05764 1126211006403 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211006404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211006405 homodimer interface [polypeptide binding]; other site 1126211006406 catalytic residue [active] 1126211006407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1126211006408 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1126211006409 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1126211006410 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1126211006411 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1126211006412 active site 1126211006413 catalytic site [active] 1126211006414 substrate binding site [chemical binding]; other site 1126211006415 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1126211006416 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1126211006417 tetramerization interface [polypeptide binding]; other site 1126211006418 active site 1126211006419 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1126211006420 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1126211006421 active site 1126211006422 ATP-binding site [chemical binding]; other site 1126211006423 pantoate-binding site; other site 1126211006424 HXXH motif; other site 1126211006425 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1126211006426 oligomerization interface [polypeptide binding]; other site 1126211006427 active site 1126211006428 metal binding site [ion binding]; metal-binding site 1126211006429 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1126211006430 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1126211006431 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1126211006432 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1126211006433 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1126211006434 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1126211006435 active site 1126211006436 NTP binding site [chemical binding]; other site 1126211006437 metal binding triad [ion binding]; metal-binding site 1126211006438 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1126211006439 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1126211006440 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1126211006441 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1126211006442 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1126211006443 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1126211006444 active site 1126211006445 dimer interfaces [polypeptide binding]; other site 1126211006446 catalytic residues [active] 1126211006447 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1126211006448 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1126211006449 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1126211006450 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1126211006451 homodimer interface [polypeptide binding]; other site 1126211006452 metal binding site [ion binding]; metal-binding site 1126211006453 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1126211006454 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1126211006455 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1126211006456 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1126211006457 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1126211006458 Cupin; Region: Cupin_1; smart00835 1126211006459 Cupin; Region: Cupin_1; smart00835 1126211006460 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 1126211006461 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 1126211006462 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1126211006463 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1126211006464 interchain domain interface [polypeptide binding]; other site 1126211006465 intrachain domain interface; other site 1126211006466 heme bH binding site [chemical binding]; other site 1126211006467 Qi binding site; other site 1126211006468 heme bL binding site [chemical binding]; other site 1126211006469 Qo binding site; other site 1126211006470 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1126211006471 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1126211006472 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1126211006473 iron-sulfur cluster [ion binding]; other site 1126211006474 [2Fe-2S] cluster binding site [ion binding]; other site 1126211006475 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1126211006476 hypothetical protein; Provisional; Region: PRK03636 1126211006477 UPF0302 domain; Region: UPF0302; pfam08864 1126211006478 IDEAL domain; Region: IDEAL; pfam08858 1126211006479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1126211006480 TPR motif; other site 1126211006481 binding surface 1126211006482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1126211006483 binding surface 1126211006484 TPR motif; other site 1126211006485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211006486 TPR motif; other site 1126211006487 binding surface 1126211006488 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1126211006489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211006490 binding surface 1126211006491 TPR motif; other site 1126211006492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1126211006493 binding surface 1126211006494 TPR motif; other site 1126211006495 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1126211006496 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1126211006497 hinge; other site 1126211006498 active site 1126211006499 prephenate dehydrogenase; Validated; Region: PRK06545 1126211006500 prephenate dehydrogenase; Validated; Region: PRK08507 1126211006501 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1126211006502 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1126211006503 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211006504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211006505 homodimer interface [polypeptide binding]; other site 1126211006506 catalytic residue [active] 1126211006507 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1126211006508 substrate binding site [chemical binding]; other site 1126211006509 active site 1126211006510 catalytic residues [active] 1126211006511 heterodimer interface [polypeptide binding]; other site 1126211006512 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1126211006513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1126211006514 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1126211006515 active site 1126211006516 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1126211006517 active site 1126211006518 ribulose/triose binding site [chemical binding]; other site 1126211006519 phosphate binding site [ion binding]; other site 1126211006520 substrate (anthranilate) binding pocket [chemical binding]; other site 1126211006521 product (indole) binding pocket [chemical binding]; other site 1126211006522 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1126211006523 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1126211006524 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1126211006525 anthranilate synthase component I; Provisional; Region: PRK13569 1126211006526 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1126211006527 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1126211006528 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1126211006529 homotrimer interaction site [polypeptide binding]; other site 1126211006530 active site 1126211006531 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1126211006532 active site 1126211006533 dimer interface [polypeptide binding]; other site 1126211006534 metal binding site [ion binding]; metal-binding site 1126211006535 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1126211006536 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1126211006537 Tetramer interface [polypeptide binding]; other site 1126211006538 active site 1126211006539 FMN-binding site [chemical binding]; other site 1126211006540 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1126211006541 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1126211006542 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1126211006543 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1126211006544 active site 1126211006545 multimer interface [polypeptide binding]; other site 1126211006546 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1126211006547 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1126211006548 substrate binding pocket [chemical binding]; other site 1126211006549 chain length determination region; other site 1126211006550 substrate-Mg2+ binding site; other site 1126211006551 catalytic residues [active] 1126211006552 aspartate-rich region 1; other site 1126211006553 active site lid residues [active] 1126211006554 aspartate-rich region 2; other site 1126211006555 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1126211006556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211006557 S-adenosylmethionine binding site [chemical binding]; other site 1126211006558 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1126211006559 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 1126211006560 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1126211006561 homodecamer interface [polypeptide binding]; other site 1126211006562 GTP cyclohydrolase I; Provisional; Region: PLN03044 1126211006563 active site 1126211006564 putative catalytic site residues [active] 1126211006565 zinc binding site [ion binding]; other site 1126211006566 GTP-CH-I/GFRP interaction surface; other site 1126211006567 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1126211006568 IHF dimer interface [polypeptide binding]; other site 1126211006569 IHF - DNA interface [nucleotide binding]; other site 1126211006570 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1126211006571 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1126211006572 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1126211006573 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1126211006574 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1126211006575 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1126211006576 GTP-binding protein Der; Reviewed; Region: PRK00093 1126211006577 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1126211006578 G1 box; other site 1126211006579 GTP/Mg2+ binding site [chemical binding]; other site 1126211006580 Switch I region; other site 1126211006581 G2 box; other site 1126211006582 Switch II region; other site 1126211006583 G3 box; other site 1126211006584 G4 box; other site 1126211006585 G5 box; other site 1126211006586 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1126211006587 G1 box; other site 1126211006588 GTP/Mg2+ binding site [chemical binding]; other site 1126211006589 Switch I region; other site 1126211006590 G2 box; other site 1126211006591 G3 box; other site 1126211006592 Switch II region; other site 1126211006593 G4 box; other site 1126211006594 G5 box; other site 1126211006595 YpzI-like protein; Region: YpzI; pfam14140 1126211006596 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1126211006597 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1126211006598 homotetramer interface [polypeptide binding]; other site 1126211006599 FMN binding site [chemical binding]; other site 1126211006600 homodimer contacts [polypeptide binding]; other site 1126211006601 putative active site [active] 1126211006602 putative substrate binding site [chemical binding]; other site 1126211006603 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1126211006604 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1126211006605 RNA binding site [nucleotide binding]; other site 1126211006606 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1126211006607 RNA binding site [nucleotide binding]; other site 1126211006608 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1126211006609 RNA binding site [nucleotide binding]; other site 1126211006610 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1126211006611 RNA binding site [nucleotide binding]; other site 1126211006612 cytidylate kinase; Provisional; Region: cmk; PRK00023 1126211006613 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1126211006614 CMP-binding site; other site 1126211006615 The sites determining sugar specificity; other site 1126211006616 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1126211006617 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1126211006618 PilZ domain; Region: PilZ; pfam07238 1126211006619 germination protein YpeB; Region: spore_YpeB; TIGR02889 1126211006620 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1126211006621 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1126211006622 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1126211006623 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1126211006624 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1126211006625 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1126211006626 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1126211006627 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1126211006628 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1126211006629 NAD(P) binding site [chemical binding]; other site 1126211006630 adaptor protein; Provisional; Region: PRK02899 1126211006631 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1126211006632 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1126211006633 putative active site [active] 1126211006634 putative metal binding site [ion binding]; other site 1126211006635 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1126211006636 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1126211006637 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211006638 CAAX protease self-immunity; Region: Abi; pfam02517 1126211006639 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1126211006640 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1126211006641 ATP binding site [chemical binding]; other site 1126211006642 putative Mg++ binding site [ion binding]; other site 1126211006643 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211006644 nucleotide binding region [chemical binding]; other site 1126211006645 ATP-binding site [chemical binding]; other site 1126211006646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1126211006647 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1126211006648 Predicted membrane protein [Function unknown]; Region: COG3601 1126211006649 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1126211006650 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1126211006651 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1126211006652 ligand binding site [chemical binding]; other site 1126211006653 NAD binding site [chemical binding]; other site 1126211006654 dimerization interface [polypeptide binding]; other site 1126211006655 catalytic site [active] 1126211006656 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1126211006657 putative L-serine binding site [chemical binding]; other site 1126211006658 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1126211006659 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1126211006660 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1126211006661 DNA binding residues [nucleotide binding] 1126211006662 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1126211006663 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1126211006664 dimerization interface [polypeptide binding]; other site 1126211006665 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1126211006666 putative active site [active] 1126211006667 heme pocket [chemical binding]; other site 1126211006668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211006669 dimer interface [polypeptide binding]; other site 1126211006670 phosphorylation site [posttranslational modification] 1126211006671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211006672 ATP binding site [chemical binding]; other site 1126211006673 Mg2+ binding site [ion binding]; other site 1126211006674 G-X-G motif; other site 1126211006675 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211006676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211006677 active site 1126211006678 phosphorylation site [posttranslational modification] 1126211006679 intermolecular recognition site; other site 1126211006680 dimerization interface [polypeptide binding]; other site 1126211006681 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211006682 DNA binding site [nucleotide binding] 1126211006683 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1126211006684 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1126211006685 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1126211006686 ResB-like family; Region: ResB; pfam05140 1126211006687 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1126211006688 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1126211006689 catalytic residues [active] 1126211006690 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1126211006691 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1126211006692 RNA binding surface [nucleotide binding]; other site 1126211006693 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1126211006694 active site 1126211006695 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1126211006696 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1126211006697 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1126211006698 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1126211006699 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1126211006700 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1126211006701 segregation and condensation protein B; Region: TIGR00281 1126211006702 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1126211006703 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1126211006704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211006705 Coenzyme A binding pocket [chemical binding]; other site 1126211006706 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1126211006707 homopentamer interface [polypeptide binding]; other site 1126211006708 active site 1126211006709 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1126211006710 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1126211006711 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1126211006712 dimerization interface [polypeptide binding]; other site 1126211006713 active site 1126211006714 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1126211006715 Lumazine binding domain; Region: Lum_binding; pfam00677 1126211006716 Lumazine binding domain; Region: Lum_binding; pfam00677 1126211006717 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1126211006718 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1126211006719 catalytic motif [active] 1126211006720 Zn binding site [ion binding]; other site 1126211006721 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1126211006722 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1126211006723 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1126211006724 Catalytic site [active] 1126211006725 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1126211006726 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1126211006727 active site 1126211006728 Predicted secreted protein [Function unknown]; Region: COG4086 1126211006729 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1126211006730 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1126211006731 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1126211006732 active site 1126211006733 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1126211006734 substrate binding site [chemical binding]; other site 1126211006735 catalytic residues [active] 1126211006736 dimer interface [polypeptide binding]; other site 1126211006737 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1126211006738 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1126211006739 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1126211006740 stage V sporulation protein AD; Validated; Region: PRK08304 1126211006741 stage V sporulation protein AD; Provisional; Region: PRK12404 1126211006742 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1126211006743 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1126211006744 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1126211006745 sporulation sigma factor SigF; Validated; Region: PRK05572 1126211006746 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1126211006747 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1126211006748 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1126211006749 DNA binding residues [nucleotide binding] 1126211006750 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1126211006751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211006752 ATP binding site [chemical binding]; other site 1126211006753 Mg2+ binding site [ion binding]; other site 1126211006754 G-X-G motif; other site 1126211006755 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1126211006756 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1126211006757 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1126211006758 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1126211006759 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1126211006760 phosphopentomutase; Provisional; Region: PRK05362 1126211006761 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1126211006762 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1126211006763 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1126211006764 active site 1126211006765 Int/Topo IB signature motif; other site 1126211006766 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1126211006767 ferric uptake regulator; Provisional; Region: fur; PRK09462 1126211006768 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1126211006769 metal binding site 2 [ion binding]; metal-binding site 1126211006770 putative DNA binding helix; other site 1126211006771 metal binding site 1 [ion binding]; metal-binding site 1126211006772 dimer interface [polypeptide binding]; other site 1126211006773 structural Zn2+ binding site [ion binding]; other site 1126211006774 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1126211006775 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1126211006776 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1126211006777 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1126211006778 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 1126211006779 NAD(P) binding pocket [chemical binding]; other site 1126211006780 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1126211006781 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1126211006782 Aspartase; Region: Aspartase; cd01357 1126211006783 active sites [active] 1126211006784 tetramer interface [polypeptide binding]; other site 1126211006785 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1126211006786 active site 1126211006787 homodimer interface [polypeptide binding]; other site 1126211006788 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1126211006789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211006790 non-specific DNA binding site [nucleotide binding]; other site 1126211006791 salt bridge; other site 1126211006792 sequence-specific DNA binding site [nucleotide binding]; other site 1126211006793 TIGR00375 family protein; Region: TIGR00375 1126211006794 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1126211006795 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1126211006796 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1126211006797 dimer interface [polypeptide binding]; other site 1126211006798 ADP-ribose binding site [chemical binding]; other site 1126211006799 active site 1126211006800 nudix motif; other site 1126211006801 metal binding site [ion binding]; metal-binding site 1126211006802 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1126211006803 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1126211006804 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1126211006805 active site 1126211006806 catalytic tetrad [active] 1126211006807 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1126211006808 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1126211006809 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1126211006810 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1126211006811 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1126211006812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1126211006813 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1126211006814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211006815 Coenzyme A binding pocket [chemical binding]; other site 1126211006816 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1126211006817 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1126211006818 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1126211006819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211006820 Coenzyme A binding pocket [chemical binding]; other site 1126211006821 DNA polymerase IV; Reviewed; Region: PRK03103 1126211006822 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1126211006823 active site 1126211006824 DNA binding site [nucleotide binding] 1126211006825 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1126211006826 YolD-like protein; Region: YolD; pfam08863 1126211006827 YqzH-like protein; Region: YqzH; pfam14164 1126211006828 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1126211006829 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1126211006830 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1126211006831 putative dimer interface [polypeptide binding]; other site 1126211006832 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1126211006833 ligand binding site [chemical binding]; other site 1126211006834 Zn binding site [ion binding]; other site 1126211006835 pantothenate kinase; Provisional; Region: PRK05439 1126211006836 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1126211006837 ATP-binding site [chemical binding]; other site 1126211006838 CoA-binding site [chemical binding]; other site 1126211006839 Mg2+-binding site [ion binding]; other site 1126211006840 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1126211006841 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1126211006842 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1126211006843 catalytic residue [active] 1126211006844 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1126211006845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1126211006846 NAD(P) binding site [chemical binding]; other site 1126211006847 active site 1126211006848 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1126211006849 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1126211006850 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1126211006851 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1126211006852 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1126211006853 substrate binding site [chemical binding]; other site 1126211006854 oxyanion hole (OAH) forming residues; other site 1126211006855 trimer interface [polypeptide binding]; other site 1126211006856 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1126211006857 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1126211006858 dimer interface [polypeptide binding]; other site 1126211006859 active site 1126211006860 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1126211006861 Cytochrome P450; Region: p450; cl12078 1126211006862 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1126211006863 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1126211006864 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211006865 polyketide synthase; Region: polyketide_synthase; cd08251 1126211006866 Enoylreductase; Region: PKS_ER; smart00829 1126211006867 putative NAD(P) binding site [chemical binding]; other site 1126211006868 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211006869 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211006870 active site 1126211006871 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211006872 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211006873 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1126211006874 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1126211006875 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211006876 active site 1126211006877 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211006878 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211006879 putative NADP binding site [chemical binding]; other site 1126211006880 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211006881 active site 1126211006882 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211006883 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211006884 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211006885 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211006886 putative NADP binding site [chemical binding]; other site 1126211006887 active site 1126211006888 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211006889 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211006890 active site 1126211006891 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211006892 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211006893 putative NADP binding site [chemical binding]; other site 1126211006894 active site 1126211006895 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211006896 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211006897 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211006898 active site 1126211006899 potential frameshift: common BLAST hit: gi|384265982|ref|YP_005421689.1| difficidin synthase 1126211006900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1126211006901 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211006902 active site 1126211006903 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211006904 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1126211006905 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211006906 active site 1126211006907 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211006908 putative NADP binding site [chemical binding]; other site 1126211006909 active site 1126211006910 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211006911 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211006912 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211006913 active site 1126211006914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211006915 S-adenosylmethionine binding site [chemical binding]; other site 1126211006916 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211006917 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1126211006918 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211006919 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211006920 active site 1126211006921 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211006922 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211006923 KR domain; Region: KR; pfam08659 1126211006924 putative NADP binding site [chemical binding]; other site 1126211006925 active site 1126211006926 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211006927 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211006928 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211006929 active site 1126211006930 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211006931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1126211006932 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211006933 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211006934 putative NADP binding site [chemical binding]; other site 1126211006935 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211006936 active site 1126211006937 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1126211006938 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211006939 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211006940 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211006941 active site 1126211006942 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1126211006943 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1126211006944 putative NADP binding site [chemical binding]; other site 1126211006945 active site 1126211006946 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211006947 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1126211006948 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1126211006949 active site 1126211006950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1126211006951 NAD(P) binding site [chemical binding]; other site 1126211006952 active site 1126211006953 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1126211006954 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1126211006955 acyl-activating enzyme (AAE) consensus motif; other site 1126211006956 active site 1126211006957 AMP binding site [chemical binding]; other site 1126211006958 CoA binding site [chemical binding]; other site 1126211006959 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1126211006960 biosynthesis cluster domain; Region: biosyn_clust_1; TIGR04098 1126211006961 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1126211006962 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1126211006963 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1126211006964 FMN binding site [chemical binding]; other site 1126211006965 substrate binding site [chemical binding]; other site 1126211006966 putative catalytic residue [active] 1126211006967 Transcription antiterminator [Transcription]; Region: NusG; COG0250 1126211006968 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 1126211006969 Cupin domain; Region: Cupin_2; pfam07883 1126211006970 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1126211006971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1126211006972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1126211006973 dimerization interface [polypeptide binding]; other site 1126211006974 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1126211006975 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1126211006976 active site 1126211006977 FMN binding site [chemical binding]; other site 1126211006978 substrate binding site [chemical binding]; other site 1126211006979 homotetramer interface [polypeptide binding]; other site 1126211006980 catalytic residue [active] 1126211006981 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1126211006982 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1126211006983 ribonuclease Z; Region: RNase_Z; TIGR02651 1126211006984 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1126211006985 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1126211006986 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1126211006987 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1126211006988 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1126211006989 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1126211006990 DNA polymerase IV; Validated; Region: PRK01810 1126211006991 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1126211006992 active site 1126211006993 DNA binding site [nucleotide binding] 1126211006994 OxaA-like protein precursor; Validated; Region: PRK01622 1126211006995 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1126211006996 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1126211006997 peptidase T-like protein; Region: PepT-like; TIGR01883 1126211006998 metal binding site [ion binding]; metal-binding site 1126211006999 putative dimer interface [polypeptide binding]; other site 1126211007000 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1126211007001 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1126211007002 dimer interface [polypeptide binding]; other site 1126211007003 substrate binding site [chemical binding]; other site 1126211007004 metal binding site [ion binding]; metal-binding site 1126211007005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1126211007006 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1126211007007 Predicted membrane protein [Function unknown]; Region: COG4129 1126211007008 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1126211007009 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1126211007010 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1126211007011 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1126211007012 Walker A/P-loop; other site 1126211007013 ATP binding site [chemical binding]; other site 1126211007014 Q-loop/lid; other site 1126211007015 ABC transporter signature motif; other site 1126211007016 Walker B; other site 1126211007017 D-loop; other site 1126211007018 H-loop/switch region; other site 1126211007019 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1126211007020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211007021 dimer interface [polypeptide binding]; other site 1126211007022 conserved gate region; other site 1126211007023 putative PBP binding loops; other site 1126211007024 ABC-ATPase subunit interface; other site 1126211007025 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1126211007026 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1126211007027 substrate binding pocket [chemical binding]; other site 1126211007028 membrane-bound complex binding site; other site 1126211007029 hinge residues; other site 1126211007030 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1126211007031 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1126211007032 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1126211007033 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1126211007034 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1126211007035 E3 interaction surface; other site 1126211007036 lipoyl attachment site [posttranslational modification]; other site 1126211007037 e3 binding domain; Region: E3_binding; pfam02817 1126211007038 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1126211007039 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1126211007040 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1126211007041 alpha subunit interface [polypeptide binding]; other site 1126211007042 TPP binding site [chemical binding]; other site 1126211007043 heterodimer interface [polypeptide binding]; other site 1126211007044 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1126211007045 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1126211007046 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1126211007047 tetramer interface [polypeptide binding]; other site 1126211007048 TPP-binding site [chemical binding]; other site 1126211007049 heterodimer interface [polypeptide binding]; other site 1126211007050 phosphorylation loop region [posttranslational modification] 1126211007051 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1126211007052 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1126211007053 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1126211007054 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1126211007055 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1126211007056 nucleotide binding site [chemical binding]; other site 1126211007057 Acetokinase family; Region: Acetate_kinase; cl17229 1126211007058 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1126211007059 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1126211007060 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1126211007061 NAD binding site [chemical binding]; other site 1126211007062 Phe binding site; other site 1126211007063 phosphate butyryltransferase; Validated; Region: PRK07742 1126211007064 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1126211007065 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1126211007066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1126211007067 putative active site [active] 1126211007068 heme pocket [chemical binding]; other site 1126211007069 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1126211007070 putative active site [active] 1126211007071 heme pocket [chemical binding]; other site 1126211007072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211007073 Walker A motif; other site 1126211007074 ATP binding site [chemical binding]; other site 1126211007075 Walker B motif; other site 1126211007076 arginine finger; other site 1126211007077 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1126211007078 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1126211007079 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1126211007080 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1126211007081 tetramer interface [polypeptide binding]; other site 1126211007082 active site 1126211007083 Mg2+/Mn2+ binding site [ion binding]; other site 1126211007084 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1126211007085 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1126211007086 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1126211007087 dimer interface [polypeptide binding]; other site 1126211007088 Citrate synthase; Region: Citrate_synt; pfam00285 1126211007089 active site 1126211007090 coenzyme A binding site [chemical binding]; other site 1126211007091 citrylCoA binding site [chemical binding]; other site 1126211007092 oxalacetate/citrate binding site [chemical binding]; other site 1126211007093 catalytic triad [active] 1126211007094 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1126211007095 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1126211007096 FAD binding site [chemical binding]; other site 1126211007097 homotetramer interface [polypeptide binding]; other site 1126211007098 substrate binding pocket [chemical binding]; other site 1126211007099 catalytic base [active] 1126211007100 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1126211007101 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1126211007102 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1126211007103 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1126211007104 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1126211007105 dimer interface [polypeptide binding]; other site 1126211007106 active site 1126211007107 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1126211007108 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1126211007109 active site 1126211007110 catalytic site [active] 1126211007111 metal binding site [ion binding]; metal-binding site 1126211007112 dimer interface [polypeptide binding]; other site 1126211007113 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1126211007114 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1126211007115 active site 1126211007116 metal binding site [ion binding]; metal-binding site 1126211007117 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1126211007118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211007119 sequence-specific DNA binding site [nucleotide binding]; other site 1126211007120 salt bridge; other site 1126211007121 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1126211007122 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1126211007123 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1126211007124 putative active site [active] 1126211007125 putative FMN binding site [chemical binding]; other site 1126211007126 putative substrate binding site [chemical binding]; other site 1126211007127 putative catalytic residue [active] 1126211007128 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1126211007129 alanine racemase; Region: alr; TIGR00492 1126211007130 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1126211007131 active site 1126211007132 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1126211007133 dimer interface [polypeptide binding]; other site 1126211007134 substrate binding site [chemical binding]; other site 1126211007135 catalytic residues [active] 1126211007136 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1126211007137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211007138 active site 1126211007139 phosphorylation site [posttranslational modification] 1126211007140 intermolecular recognition site; other site 1126211007141 dimerization interface [polypeptide binding]; other site 1126211007142 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1126211007143 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1126211007144 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1126211007145 protein binding site [polypeptide binding]; other site 1126211007146 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1126211007147 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1126211007148 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1126211007149 Walker A/P-loop; other site 1126211007150 ATP binding site [chemical binding]; other site 1126211007151 Q-loop/lid; other site 1126211007152 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1126211007153 ABC transporter signature motif; other site 1126211007154 Walker B; other site 1126211007155 D-loop; other site 1126211007156 H-loop/switch region; other site 1126211007157 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1126211007158 arginine repressor; Provisional; Region: PRK04280 1126211007159 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1126211007160 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1126211007161 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1126211007162 RNA binding surface [nucleotide binding]; other site 1126211007163 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1126211007164 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1126211007165 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1126211007166 TPP-binding site; other site 1126211007167 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1126211007168 PYR/PP interface [polypeptide binding]; other site 1126211007169 dimer interface [polypeptide binding]; other site 1126211007170 TPP binding site [chemical binding]; other site 1126211007171 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1126211007172 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1126211007173 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1126211007174 substrate binding pocket [chemical binding]; other site 1126211007175 chain length determination region; other site 1126211007176 substrate-Mg2+ binding site; other site 1126211007177 catalytic residues [active] 1126211007178 aspartate-rich region 1; other site 1126211007179 active site lid residues [active] 1126211007180 aspartate-rich region 2; other site 1126211007181 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1126211007182 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1126211007183 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1126211007184 generic binding surface II; other site 1126211007185 generic binding surface I; other site 1126211007186 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1126211007187 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1126211007188 putative RNA binding site [nucleotide binding]; other site 1126211007189 Asp23 family; Region: Asp23; pfam03780 1126211007190 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1126211007191 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1126211007192 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1126211007193 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1126211007194 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1126211007195 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1126211007196 carboxyltransferase (CT) interaction site; other site 1126211007197 biotinylation site [posttranslational modification]; other site 1126211007198 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1126211007199 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1126211007200 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1126211007201 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1126211007202 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1126211007203 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1126211007204 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1126211007205 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1126211007206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211007207 Walker A motif; other site 1126211007208 ATP binding site [chemical binding]; other site 1126211007209 Walker B motif; other site 1126211007210 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1126211007211 elongation factor P; Validated; Region: PRK00529 1126211007212 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1126211007213 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1126211007214 RNA binding site [nucleotide binding]; other site 1126211007215 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1126211007216 RNA binding site [nucleotide binding]; other site 1126211007217 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1126211007218 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1126211007219 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1126211007220 active site 1126211007221 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1126211007222 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1126211007223 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1126211007224 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1126211007225 active site 1126211007226 nucleophile elbow; other site 1126211007227 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1126211007228 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1126211007229 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1126211007230 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1126211007231 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1126211007232 active site residue [active] 1126211007233 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1126211007234 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1126211007235 tetramer interface [polypeptide binding]; other site 1126211007236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211007237 catalytic residue [active] 1126211007238 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1126211007239 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1126211007240 tetramer interface [polypeptide binding]; other site 1126211007241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211007242 catalytic residue [active] 1126211007243 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1126211007244 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1126211007245 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1126211007246 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1126211007247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1126211007248 ATP binding site [chemical binding]; other site 1126211007249 putative Mg++ binding site [ion binding]; other site 1126211007250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211007251 nucleotide binding region [chemical binding]; other site 1126211007252 ATP-binding site [chemical binding]; other site 1126211007253 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1126211007254 Anti-repressor SinI; Region: SinI; pfam08671 1126211007255 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1126211007256 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211007257 non-specific DNA binding site [nucleotide binding]; other site 1126211007258 salt bridge; other site 1126211007259 sequence-specific DNA binding site [nucleotide binding]; other site 1126211007260 Anti-repressor SinI; Region: SinI; pfam08671 1126211007261 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1126211007262 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1126211007263 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1126211007264 Catalytic site [active] 1126211007265 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1126211007266 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1126211007267 YqzE-like protein; Region: YqzE; pfam14038 1126211007268 ComG operon protein 7; Region: ComGG; pfam14173 1126211007269 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1126211007270 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1126211007271 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1126211007272 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1126211007273 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1126211007274 Type II/IV secretion system protein; Region: T2SE; pfam00437 1126211007275 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1126211007276 Walker A motif; other site 1126211007277 ATP binding site [chemical binding]; other site 1126211007278 Walker B motif; other site 1126211007279 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1126211007280 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1126211007281 Cl binding site [ion binding]; other site 1126211007282 oligomer interface [polypeptide binding]; other site 1126211007283 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1126211007284 Domain of unknown function DUF21; Region: DUF21; pfam01595 1126211007285 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1126211007286 Transporter associated domain; Region: CorC_HlyC; smart01091 1126211007287 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1126211007288 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1126211007289 ArsC family; Region: ArsC; pfam03960 1126211007290 putative catalytic residues [active] 1126211007291 thiol/disulfide switch; other site 1126211007292 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1126211007293 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1126211007294 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1126211007295 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1126211007296 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1126211007297 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1126211007298 putative active site [active] 1126211007299 Zn binding site [ion binding]; other site 1126211007300 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1126211007301 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1126211007302 nucleotide binding site [chemical binding]; other site 1126211007303 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1126211007304 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1126211007305 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1126211007306 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1126211007307 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1126211007308 YceG-like family; Region: YceG; pfam02618 1126211007309 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1126211007310 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1126211007311 Walker A/P-loop; other site 1126211007312 ATP binding site [chemical binding]; other site 1126211007313 Q-loop/lid; other site 1126211007314 ABC transporter signature motif; other site 1126211007315 Walker B; other site 1126211007316 D-loop; other site 1126211007317 H-loop/switch region; other site 1126211007318 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1126211007319 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1126211007320 Walker A/P-loop; other site 1126211007321 ATP binding site [chemical binding]; other site 1126211007322 Q-loop/lid; other site 1126211007323 ABC transporter signature motif; other site 1126211007324 Walker B; other site 1126211007325 D-loop; other site 1126211007326 H-loop/switch region; other site 1126211007327 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1126211007328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211007329 dimer interface [polypeptide binding]; other site 1126211007330 conserved gate region; other site 1126211007331 ABC-ATPase subunit interface; other site 1126211007332 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1126211007333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211007334 dimer interface [polypeptide binding]; other site 1126211007335 conserved gate region; other site 1126211007336 putative PBP binding loops; other site 1126211007337 ABC-ATPase subunit interface; other site 1126211007338 PBP superfamily domain; Region: PBP_like_2; cl17296 1126211007339 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1126211007340 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1126211007341 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1126211007342 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1126211007343 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211007344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211007345 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1126211007346 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1126211007347 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1126211007348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1126211007349 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1126211007350 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211007351 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1126211007352 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1126211007353 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1126211007354 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1126211007355 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1126211007356 metal binding site 2 [ion binding]; metal-binding site 1126211007357 putative DNA binding helix; other site 1126211007358 metal binding site 1 [ion binding]; metal-binding site 1126211007359 dimer interface [polypeptide binding]; other site 1126211007360 structural Zn2+ binding site [ion binding]; other site 1126211007361 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1126211007362 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1126211007363 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1126211007364 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1126211007365 endonuclease IV; Provisional; Region: PRK01060 1126211007366 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1126211007367 AP (apurinic/apyrimidinic) site pocket; other site 1126211007368 DNA interaction; other site 1126211007369 Metal-binding active site; metal-binding site 1126211007370 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1126211007371 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1126211007372 ATP binding site [chemical binding]; other site 1126211007373 Mg++ binding site [ion binding]; other site 1126211007374 motif III; other site 1126211007375 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211007376 nucleotide binding region [chemical binding]; other site 1126211007377 ATP-binding site [chemical binding]; other site 1126211007378 YqfQ-like protein; Region: YqfQ; pfam14181 1126211007379 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1126211007380 LytB protein; Region: LYTB; pfam02401 1126211007381 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1126211007382 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1126211007383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1126211007384 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1126211007385 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1126211007386 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1126211007387 Family of unknown function (DUF633); Region: DUF633; pfam04816 1126211007388 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1126211007389 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1126211007390 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1126211007391 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1126211007392 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1126211007393 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1126211007394 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1126211007395 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1126211007396 DNA binding residues [nucleotide binding] 1126211007397 DNA primase; Validated; Region: dnaG; PRK05667 1126211007398 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1126211007399 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1126211007400 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1126211007401 active site 1126211007402 metal binding site [ion binding]; metal-binding site 1126211007403 interdomain interaction site; other site 1126211007404 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1126211007405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1126211007406 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1126211007407 HTH domain; Region: HTH_11; pfam08279 1126211007408 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1126211007409 FOG: CBS domain [General function prediction only]; Region: COG0517 1126211007410 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1126211007411 DALR anticodon binding domain; Region: DALR_1; pfam05746 1126211007412 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1126211007413 dimer interface [polypeptide binding]; other site 1126211007414 motif 1; other site 1126211007415 active site 1126211007416 motif 2; other site 1126211007417 motif 3; other site 1126211007418 Recombination protein O N terminal; Region: RecO_N; pfam11967 1126211007419 DNA repair protein RecO; Region: reco; TIGR00613 1126211007420 Recombination protein O C terminal; Region: RecO_C; pfam02565 1126211007421 YqzL-like protein; Region: YqzL; pfam14006 1126211007422 GTPase Era; Reviewed; Region: era; PRK00089 1126211007423 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1126211007424 G1 box; other site 1126211007425 GTP/Mg2+ binding site [chemical binding]; other site 1126211007426 Switch I region; other site 1126211007427 G2 box; other site 1126211007428 Switch II region; other site 1126211007429 G3 box; other site 1126211007430 G4 box; other site 1126211007431 G5 box; other site 1126211007432 KH domain; Region: KH_2; pfam07650 1126211007433 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1126211007434 active site 1126211007435 catalytic motif [active] 1126211007436 Zn binding site [ion binding]; other site 1126211007437 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1126211007438 metal-binding heat shock protein; Provisional; Region: PRK00016 1126211007439 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1126211007440 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1126211007441 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1126211007442 Zn2+ binding site [ion binding]; other site 1126211007443 Mg2+ binding site [ion binding]; other site 1126211007444 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1126211007445 PhoH-like protein; Region: PhoH; pfam02562 1126211007446 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1126211007447 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1126211007448 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1126211007449 hypothetical protein; Provisional; Region: PRK13665 1126211007450 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1126211007451 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1126211007452 dimer interface [polypeptide binding]; other site 1126211007453 active site residues [active] 1126211007454 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1126211007455 Yqey-like protein; Region: YqeY; pfam09424 1126211007456 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1126211007457 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1126211007458 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1126211007459 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1126211007460 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1126211007461 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1126211007462 FeS/SAM binding site; other site 1126211007463 TRAM domain; Region: TRAM; cl01282 1126211007464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1126211007465 RNA methyltransferase, RsmE family; Region: TIGR00046 1126211007466 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1126211007467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211007468 S-adenosylmethionine binding site [chemical binding]; other site 1126211007469 chaperone protein DnaJ; Provisional; Region: PRK14280 1126211007470 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1126211007471 HSP70 interaction site [polypeptide binding]; other site 1126211007472 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1126211007473 substrate binding site [polypeptide binding]; other site 1126211007474 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1126211007475 Zn binding sites [ion binding]; other site 1126211007476 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1126211007477 dimer interface [polypeptide binding]; other site 1126211007478 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1126211007479 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1126211007480 NEF interaction site [polypeptide binding]; other site 1126211007481 nucleotide binding site [chemical binding]; other site 1126211007482 SBD interface [polypeptide binding]; other site 1126211007483 GrpE; Region: GrpE; pfam01025 1126211007484 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1126211007485 dimer interface [polypeptide binding]; other site 1126211007486 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1126211007487 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1126211007488 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1126211007489 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1126211007490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1126211007491 FeS/SAM binding site; other site 1126211007492 HemN C-terminal domain; Region: HemN_C; pfam06969 1126211007493 GTP-binding protein LepA; Provisional; Region: PRK05433 1126211007494 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1126211007495 G1 box; other site 1126211007496 putative GEF interaction site [polypeptide binding]; other site 1126211007497 GTP/Mg2+ binding site [chemical binding]; other site 1126211007498 Switch I region; other site 1126211007499 G2 box; other site 1126211007500 G3 box; other site 1126211007501 Switch II region; other site 1126211007502 G4 box; other site 1126211007503 G5 box; other site 1126211007504 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1126211007505 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1126211007506 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1126211007507 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1126211007508 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1126211007509 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1126211007510 germination protease; Provisional; Region: PRK02858 1126211007511 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1126211007512 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1126211007513 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1126211007514 YqzM-like protein; Region: YqzM; pfam14141 1126211007515 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1126211007516 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1126211007517 Competence protein; Region: Competence; pfam03772 1126211007518 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1126211007519 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1126211007520 catalytic motif [active] 1126211007521 Zn binding site [ion binding]; other site 1126211007522 SLBB domain; Region: SLBB; pfam10531 1126211007523 comEA protein; Region: comE; TIGR01259 1126211007524 Helix-hairpin-helix motif; Region: HHH; pfam00633 1126211007525 late competence protein ComER; Validated; Region: PRK07680 1126211007526 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1126211007527 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1126211007528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211007529 S-adenosylmethionine binding site [chemical binding]; other site 1126211007530 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1126211007531 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1126211007532 Zn2+ binding site [ion binding]; other site 1126211007533 Mg2+ binding site [ion binding]; other site 1126211007534 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1126211007535 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1126211007536 active site 1126211007537 (T/H)XGH motif; other site 1126211007538 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 1126211007539 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1126211007540 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1126211007541 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1126211007542 shikimate binding site; other site 1126211007543 NAD(P) binding site [chemical binding]; other site 1126211007544 GTPase YqeH; Provisional; Region: PRK13796 1126211007545 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1126211007546 GTP/Mg2+ binding site [chemical binding]; other site 1126211007547 G4 box; other site 1126211007548 G5 box; other site 1126211007549 G1 box; other site 1126211007550 Switch I region; other site 1126211007551 G2 box; other site 1126211007552 G3 box; other site 1126211007553 Switch II region; other site 1126211007554 Sporulation inhibitor A; Region: Sda; pfam08970 1126211007555 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 1126211007556 active site 1126211007557 catalytic triad [active] 1126211007558 oxyanion hole [active] 1126211007559 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1126211007560 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1126211007561 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1126211007562 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1126211007563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211007564 H+ Antiporter protein; Region: 2A0121; TIGR00900 1126211007565 putative substrate translocation pore; other site 1126211007566 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1126211007567 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1126211007568 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1126211007569 DNA binding residues [nucleotide binding] 1126211007570 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1126211007571 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1126211007572 Predicted transcriptional regulators [Transcription]; Region: COG1695 1126211007573 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1126211007574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1126211007575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1126211007576 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1126211007577 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1126211007578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1126211007579 dimerization interface [polypeptide binding]; other site 1126211007580 putative transporter; Provisional; Region: PRK11021 1126211007581 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1126211007582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211007583 HAMP domain; Region: HAMP; pfam00672 1126211007584 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211007585 dimer interface [polypeptide binding]; other site 1126211007586 phosphorylation site [posttranslational modification] 1126211007587 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1126211007588 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211007589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211007590 active site 1126211007591 phosphorylation site [posttranslational modification] 1126211007592 intermolecular recognition site; other site 1126211007593 dimerization interface [polypeptide binding]; other site 1126211007594 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211007595 DNA binding site [nucleotide binding] 1126211007596 Predicted membrane protein [Function unknown]; Region: COG2311 1126211007597 Protein of unknown function (DUF418); Region: DUF418; cl12135 1126211007598 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1126211007599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211007600 Coenzyme A binding pocket [chemical binding]; other site 1126211007601 hypothetical protein; Validated; Region: PRK06217 1126211007602 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1126211007603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211007604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211007605 putative substrate translocation pore; other site 1126211007606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211007607 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1126211007608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211007609 Coenzyme A binding pocket [chemical binding]; other site 1126211007610 DinB family; Region: DinB; pfam05163 1126211007611 DinB superfamily; Region: DinB_2; pfam12867 1126211007612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1126211007613 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1126211007614 active site 1126211007615 motif I; other site 1126211007616 motif II; other site 1126211007617 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1126211007618 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211007619 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1126211007620 active site 1126211007621 motif I; other site 1126211007622 motif II; other site 1126211007623 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1126211007624 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1126211007625 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1126211007626 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1126211007627 putative active site [active] 1126211007628 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1126211007629 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1126211007630 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1126211007631 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1126211007632 active site 1126211007633 P-loop; other site 1126211007634 phosphorylation site [posttranslational modification] 1126211007635 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1126211007636 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1126211007637 active site 1126211007638 phosphorylation site [posttranslational modification] 1126211007639 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1126211007640 HTH domain; Region: HTH_11; pfam08279 1126211007641 Mga helix-turn-helix domain; Region: Mga; pfam05043 1126211007642 PRD domain; Region: PRD; pfam00874 1126211007643 PRD domain; Region: PRD; pfam00874 1126211007644 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1126211007645 active site 1126211007646 P-loop; other site 1126211007647 phosphorylation site [posttranslational modification] 1126211007648 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1126211007649 active site 1126211007650 phosphorylation site [posttranslational modification] 1126211007651 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1126211007652 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1126211007653 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1126211007654 putative deacylase active site [active] 1126211007655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1126211007656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1126211007657 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1126211007658 putative dimerization interface [polypeptide binding]; other site 1126211007659 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1126211007660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211007661 putative substrate translocation pore; other site 1126211007662 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1126211007663 Cytochrome P450; Region: p450; pfam00067 1126211007664 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1126211007665 Flavodoxin; Region: Flavodoxin_1; pfam00258 1126211007666 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1126211007667 FAD binding pocket [chemical binding]; other site 1126211007668 FAD binding motif [chemical binding]; other site 1126211007669 catalytic residues [active] 1126211007670 NAD binding pocket [chemical binding]; other site 1126211007671 phosphate binding motif [ion binding]; other site 1126211007672 beta-alpha-beta structure motif; other site 1126211007673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211007674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211007675 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1126211007676 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 1126211007677 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1126211007678 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1126211007679 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1126211007680 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1126211007681 catalytic loop [active] 1126211007682 iron binding site [ion binding]; other site 1126211007683 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1126211007684 4Fe-4S binding domain; Region: Fer4; pfam00037 1126211007685 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1126211007686 [4Fe-4S] binding site [ion binding]; other site 1126211007687 molybdopterin cofactor binding site; other site 1126211007688 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1126211007689 molybdopterin cofactor binding site; other site 1126211007690 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1126211007691 YrhC-like protein; Region: YrhC; pfam14143 1126211007692 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1126211007693 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1126211007694 dimer interface [polypeptide binding]; other site 1126211007695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211007696 catalytic residue [active] 1126211007697 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1126211007698 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1126211007699 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1126211007700 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1126211007701 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1126211007702 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1126211007703 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1126211007704 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1126211007705 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1126211007706 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1126211007707 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1126211007708 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1126211007709 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1126211007710 substrate binding site [chemical binding]; other site 1126211007711 amidase catalytic site [active] 1126211007712 Zn binding residues [ion binding]; other site 1126211007713 Bacterial SH3 domain; Region: SH3_3; pfam08239 1126211007714 Holin family; Region: Phage_holin_4; cl01989 1126211007715 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 1126211007716 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1126211007717 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1126211007718 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1126211007719 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1126211007720 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1126211007721 Phage tail protein; Region: Sipho_tail; pfam05709 1126211007722 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1126211007723 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1126211007724 catalytic residue [active] 1126211007725 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1126211007726 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1126211007727 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1126211007728 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1126211007729 oligomerization interface [polypeptide binding]; other site 1126211007730 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1126211007731 Phage capsid family; Region: Phage_capsid; pfam05065 1126211007732 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1126211007733 Phage-related protein [Function unknown]; Region: COG4695 1126211007734 Phage portal protein; Region: Phage_portal; pfam04860 1126211007735 Phage Terminase; Region: Terminase_1; pfam03354 1126211007736 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1126211007737 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1126211007738 Int/Topo IB signature motif; other site 1126211007739 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1126211007740 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1126211007741 active site 1126211007742 homodimer interface [polypeptide binding]; other site 1126211007743 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1126211007744 dUTPase; Region: dUTPase_2; pfam08761 1126211007745 Helix-turn-helix domain; Region: HTH_17; cl17695 1126211007746 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 1126211007747 proteasome-activating nucleotidase; Provisional; Region: PRK03992 1126211007748 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1126211007749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1126211007750 Walker A motif; other site 1126211007751 ATP binding site [chemical binding]; other site 1126211007752 Walker B motif; other site 1126211007753 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 1126211007754 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211007755 non-specific DNA binding site [nucleotide binding]; other site 1126211007756 salt bridge; other site 1126211007757 sequence-specific DNA binding site [nucleotide binding]; other site 1126211007758 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1126211007759 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1126211007760 Int/Topo IB signature motif; other site 1126211007761 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1126211007762 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1126211007763 Peptidase family U32; Region: Peptidase_U32; pfam01136 1126211007764 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1126211007765 Peptidase family U32; Region: Peptidase_U32; pfam01136 1126211007766 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1126211007767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211007768 S-adenosylmethionine binding site [chemical binding]; other site 1126211007769 conserved hypothetical protein, YceG family; Region: TIGR00247 1126211007770 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1126211007771 dimerization interface [polypeptide binding]; other site 1126211007772 hypothetical protein; Provisional; Region: PRK13678 1126211007773 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 1126211007774 hypothetical protein; Provisional; Region: PRK05473 1126211007775 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1126211007776 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1126211007777 motif 1; other site 1126211007778 active site 1126211007779 motif 2; other site 1126211007780 motif 3; other site 1126211007781 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1126211007782 DHHA1 domain; Region: DHHA1; pfam02272 1126211007783 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1126211007784 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1126211007785 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1126211007786 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1126211007787 Walker A/P-loop; other site 1126211007788 ATP binding site [chemical binding]; other site 1126211007789 Q-loop/lid; other site 1126211007790 ABC transporter signature motif; other site 1126211007791 Walker B; other site 1126211007792 D-loop; other site 1126211007793 H-loop/switch region; other site 1126211007794 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1126211007795 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1126211007796 substrate binding pocket [chemical binding]; other site 1126211007797 membrane-bound complex binding site; other site 1126211007798 hinge residues; other site 1126211007799 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1126211007800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211007801 dimer interface [polypeptide binding]; other site 1126211007802 conserved gate region; other site 1126211007803 putative PBP binding loops; other site 1126211007804 ABC-ATPase subunit interface; other site 1126211007805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211007806 dimer interface [polypeptide binding]; other site 1126211007807 conserved gate region; other site 1126211007808 putative PBP binding loops; other site 1126211007809 ABC-ATPase subunit interface; other site 1126211007810 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1126211007811 PRC-barrel domain; Region: PRC; pfam05239 1126211007812 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1126211007813 AAA domain; Region: AAA_30; pfam13604 1126211007814 Family description; Region: UvrD_C_2; pfam13538 1126211007815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211007816 binding surface 1126211007817 TPR repeat; Region: TPR_11; pfam13414 1126211007818 TPR motif; other site 1126211007819 TPR repeat; Region: TPR_11; pfam13414 1126211007820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211007821 binding surface 1126211007822 TPR motif; other site 1126211007823 TPR repeat; Region: TPR_11; pfam13414 1126211007824 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1126211007825 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1126211007826 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1126211007827 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1126211007828 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1126211007829 catalytic residue [active] 1126211007830 Predicted transcriptional regulator [Transcription]; Region: COG1959 1126211007831 Transcriptional regulator; Region: Rrf2; pfam02082 1126211007832 recombination factor protein RarA; Reviewed; Region: PRK13342 1126211007833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211007834 Walker A motif; other site 1126211007835 ATP binding site [chemical binding]; other site 1126211007836 Walker B motif; other site 1126211007837 arginine finger; other site 1126211007838 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1126211007839 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1126211007840 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1126211007841 putative ATP binding site [chemical binding]; other site 1126211007842 putative substrate interface [chemical binding]; other site 1126211007843 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1126211007844 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1126211007845 dimer interface [polypeptide binding]; other site 1126211007846 anticodon binding site; other site 1126211007847 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1126211007848 homodimer interface [polypeptide binding]; other site 1126211007849 motif 1; other site 1126211007850 active site 1126211007851 motif 2; other site 1126211007852 GAD domain; Region: GAD; pfam02938 1126211007853 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1126211007854 active site 1126211007855 motif 3; other site 1126211007856 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1126211007857 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1126211007858 dimer interface [polypeptide binding]; other site 1126211007859 motif 1; other site 1126211007860 active site 1126211007861 motif 2; other site 1126211007862 motif 3; other site 1126211007863 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1126211007864 anticodon binding site; other site 1126211007865 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1126211007866 Bacterial SH3 domain; Region: SH3_3; pfam08239 1126211007867 Bacterial SH3 domain; Region: SH3_3; pfam08239 1126211007868 Bacterial SH3 domain; Region: SH3_3; pfam08239 1126211007869 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1126211007870 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1126211007871 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1126211007872 active site 1126211007873 metal binding site [ion binding]; metal-binding site 1126211007874 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1126211007875 putative active site [active] 1126211007876 dimerization interface [polypeptide binding]; other site 1126211007877 putative tRNAtyr binding site [nucleotide binding]; other site 1126211007878 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1126211007879 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1126211007880 Zn2+ binding site [ion binding]; other site 1126211007881 Mg2+ binding site [ion binding]; other site 1126211007882 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1126211007883 synthetase active site [active] 1126211007884 NTP binding site [chemical binding]; other site 1126211007885 metal binding site [ion binding]; metal-binding site 1126211007886 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1126211007887 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1126211007888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1126211007889 active site 1126211007890 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1126211007891 DHH family; Region: DHH; pfam01368 1126211007892 DHHA1 domain; Region: DHHA1; pfam02272 1126211007893 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1126211007894 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1126211007895 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1126211007896 TrkA-C domain; Region: TrkA_C; pfam02080 1126211007897 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1126211007898 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1126211007899 Protein export membrane protein; Region: SecD_SecF; pfam02355 1126211007900 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1126211007901 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1126211007902 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1126211007903 Predicted membrane protein [Function unknown]; Region: COG2323 1126211007904 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1126211007905 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1126211007906 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1126211007907 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1126211007908 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1126211007909 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1126211007910 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1126211007911 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1126211007912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211007913 Walker A motif; other site 1126211007914 ATP binding site [chemical binding]; other site 1126211007915 Walker B motif; other site 1126211007916 arginine finger; other site 1126211007917 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1126211007918 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1126211007919 RuvA N terminal domain; Region: RuvA_N; pfam01330 1126211007920 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1126211007921 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1126211007922 BofC C-terminal domain; Region: BofC_C; pfam08955 1126211007923 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1126211007924 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1126211007925 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211007926 quinolinate synthetase; Provisional; Region: PRK09375 1126211007927 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1126211007928 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1126211007929 dimerization interface [polypeptide binding]; other site 1126211007930 active site 1126211007931 L-aspartate oxidase; Provisional; Region: PRK08071 1126211007932 L-aspartate oxidase; Provisional; Region: PRK06175 1126211007933 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1126211007934 cysteine desulfurase; Provisional; Region: PRK02948 1126211007935 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1126211007936 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1126211007937 catalytic residue [active] 1126211007938 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1126211007939 HTH domain; Region: HTH_11; pfam08279 1126211007940 3H domain; Region: 3H; pfam02829 1126211007941 prephenate dehydratase; Provisional; Region: PRK11898 1126211007942 Prephenate dehydratase; Region: PDT; pfam00800 1126211007943 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1126211007944 putative L-Phe binding site [chemical binding]; other site 1126211007945 hypothetical protein; Provisional; Region: PRK04435 1126211007946 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1126211007947 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1126211007948 GTP1/OBG; Region: GTP1_OBG; pfam01018 1126211007949 Obg GTPase; Region: Obg; cd01898 1126211007950 G1 box; other site 1126211007951 GTP/Mg2+ binding site [chemical binding]; other site 1126211007952 Switch I region; other site 1126211007953 G2 box; other site 1126211007954 G3 box; other site 1126211007955 Switch II region; other site 1126211007956 G4 box; other site 1126211007957 G5 box; other site 1126211007958 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1126211007959 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1126211007960 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1126211007961 hypothetical protein; Provisional; Region: PRK14553 1126211007962 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1126211007963 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1126211007964 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1126211007965 Peptidase family M50; Region: Peptidase_M50; pfam02163 1126211007966 active site 1126211007967 putative substrate binding region [chemical binding]; other site 1126211007968 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1126211007969 Peptidase family M23; Region: Peptidase_M23; pfam01551 1126211007970 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1126211007971 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1126211007972 Switch I; other site 1126211007973 Switch II; other site 1126211007974 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1126211007975 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1126211007976 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1126211007977 rod shape-determining protein MreC; Region: mreC; TIGR00219 1126211007978 rod shape-determining protein MreC; Region: MreC; pfam04085 1126211007979 rod shape-determining protein MreB; Provisional; Region: PRK13927 1126211007980 MreB and similar proteins; Region: MreB_like; cd10225 1126211007981 nucleotide binding site [chemical binding]; other site 1126211007982 Mg binding site [ion binding]; other site 1126211007983 putative protofilament interaction site [polypeptide binding]; other site 1126211007984 RodZ interaction site [polypeptide binding]; other site 1126211007985 hypothetical protein; Reviewed; Region: PRK00024 1126211007986 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1126211007987 MPN+ (JAMM) motif; other site 1126211007988 Zinc-binding site [ion binding]; other site 1126211007989 Maf-like protein; Region: Maf; pfam02545 1126211007990 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1126211007991 active site 1126211007992 dimer interface [polypeptide binding]; other site 1126211007993 Sporulation related domain; Region: SPOR; pfam05036 1126211007994 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1126211007995 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1126211007996 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1126211007997 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1126211007998 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1126211007999 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1126211008000 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1126211008001 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1126211008002 active site 1126211008003 HIGH motif; other site 1126211008004 nucleotide binding site [chemical binding]; other site 1126211008005 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1126211008006 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1126211008007 active site 1126211008008 KMSKS motif; other site 1126211008009 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1126211008010 tRNA binding surface [nucleotide binding]; other site 1126211008011 anticodon binding site; other site 1126211008012 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1126211008013 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1126211008014 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1126211008015 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1126211008016 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1126211008017 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1126211008018 inhibitor-cofactor binding pocket; inhibition site 1126211008019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211008020 catalytic residue [active] 1126211008021 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1126211008022 dimer interface [polypeptide binding]; other site 1126211008023 active site 1126211008024 Schiff base residues; other site 1126211008025 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1126211008026 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1126211008027 active site 1126211008028 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1126211008029 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1126211008030 domain interfaces; other site 1126211008031 active site 1126211008032 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 1126211008033 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1126211008034 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1126211008035 tRNA; other site 1126211008036 putative tRNA binding site [nucleotide binding]; other site 1126211008037 putative NADP binding site [chemical binding]; other site 1126211008038 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1126211008039 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1126211008040 G1 box; other site 1126211008041 GTP/Mg2+ binding site [chemical binding]; other site 1126211008042 Switch I region; other site 1126211008043 G2 box; other site 1126211008044 G3 box; other site 1126211008045 Switch II region; other site 1126211008046 G4 box; other site 1126211008047 G5 box; other site 1126211008048 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1126211008049 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1126211008050 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1126211008051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211008052 Walker A motif; other site 1126211008053 ATP binding site [chemical binding]; other site 1126211008054 Walker B motif; other site 1126211008055 arginine finger; other site 1126211008056 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1126211008057 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1126211008058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211008059 Walker A motif; other site 1126211008060 ATP binding site [chemical binding]; other site 1126211008061 Walker B motif; other site 1126211008062 arginine finger; other site 1126211008063 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1126211008064 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1126211008065 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1126211008066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211008067 Walker A motif; other site 1126211008068 ATP binding site [chemical binding]; other site 1126211008069 Walker B motif; other site 1126211008070 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1126211008071 trigger factor; Provisional; Region: tig; PRK01490 1126211008072 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1126211008073 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1126211008074 TPR repeat; Region: TPR_11; pfam13414 1126211008075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211008076 binding surface 1126211008077 TPR motif; other site 1126211008078 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1126211008079 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1126211008080 substrate binding site [chemical binding]; other site 1126211008081 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1126211008082 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1126211008083 substrate binding site [chemical binding]; other site 1126211008084 ligand binding site [chemical binding]; other site 1126211008085 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1126211008086 tartrate dehydrogenase; Region: TTC; TIGR02089 1126211008087 2-isopropylmalate synthase, bacterial type; Region: leuA_bact; TIGR00973 1126211008088 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1126211008089 active site 1126211008090 metal binding site [ion binding]; metal-binding site 1126211008091 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1126211008092 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1126211008093 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1126211008094 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1126211008095 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1126211008096 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1126211008097 putative valine binding site [chemical binding]; other site 1126211008098 dimer interface [polypeptide binding]; other site 1126211008099 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1126211008100 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1126211008101 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1126211008102 PYR/PP interface [polypeptide binding]; other site 1126211008103 dimer interface [polypeptide binding]; other site 1126211008104 TPP binding site [chemical binding]; other site 1126211008105 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1126211008106 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1126211008107 TPP-binding site [chemical binding]; other site 1126211008108 dimer interface [polypeptide binding]; other site 1126211008109 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1126211008110 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1126211008111 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1126211008112 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1126211008113 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1126211008114 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1126211008115 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 1126211008116 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1126211008117 ATP binding site [chemical binding]; other site 1126211008118 putative Mg++ binding site [ion binding]; other site 1126211008119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211008120 nucleotide binding region [chemical binding]; other site 1126211008121 ATP-binding site [chemical binding]; other site 1126211008122 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1126211008123 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1126211008124 active site 1126211008125 metal binding site [ion binding]; metal-binding site 1126211008126 homotetramer interface [polypeptide binding]; other site 1126211008127 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1126211008128 active site 1126211008129 dimerization interface [polypeptide binding]; other site 1126211008130 ribonuclease PH; Reviewed; Region: rph; PRK00173 1126211008131 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1126211008132 hexamer interface [polypeptide binding]; other site 1126211008133 active site 1126211008134 Sporulation and spore germination; Region: Germane; pfam10646 1126211008135 Spore germination protein [General function prediction only]; Region: COG5401 1126211008136 Sporulation and spore germination; Region: Germane; pfam10646 1126211008137 glutamate racemase; Provisional; Region: PRK00865 1126211008138 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211008139 MarR family; Region: MarR; pfam01047 1126211008140 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1126211008141 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1126211008142 DNA binding residues [nucleotide binding] 1126211008143 dimerization interface [polypeptide binding]; other site 1126211008144 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1126211008145 active site 1126211008146 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1126211008147 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1126211008148 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1126211008149 L-aspartate oxidase; Provisional; Region: PRK06175 1126211008150 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1126211008151 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1126211008152 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1126211008153 proximal heme binding site [chemical binding]; other site 1126211008154 distal heme binding site [chemical binding]; other site 1126211008155 putative dimer interface [polypeptide binding]; other site 1126211008156 putative Iron-sulfur protein interface [polypeptide binding]; other site 1126211008157 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1126211008158 aspartate kinase; Reviewed; Region: PRK06635 1126211008159 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1126211008160 putative nucleotide binding site [chemical binding]; other site 1126211008161 putative catalytic residues [active] 1126211008162 putative Mg ion binding site [ion binding]; other site 1126211008163 putative aspartate binding site [chemical binding]; other site 1126211008164 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1126211008165 putative allosteric regulatory site; other site 1126211008166 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1126211008167 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1126211008168 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1126211008169 GIY-YIG motif/motif A; other site 1126211008170 active site 1126211008171 catalytic site [active] 1126211008172 putative DNA binding site [nucleotide binding]; other site 1126211008173 metal binding site [ion binding]; metal-binding site 1126211008174 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1126211008175 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1126211008176 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1126211008177 catalytic residues [active] 1126211008178 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1126211008179 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1126211008180 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1126211008181 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1126211008182 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1126211008183 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1126211008184 Ligand binding site [chemical binding]; other site 1126211008185 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1126211008186 enoyl-CoA hydratase; Provisional; Region: PRK07658 1126211008187 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1126211008188 substrate binding site [chemical binding]; other site 1126211008189 oxyanion hole (OAH) forming residues; other site 1126211008190 trimer interface [polypeptide binding]; other site 1126211008191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211008192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211008193 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1126211008194 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1126211008195 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1126211008196 acyl-activating enzyme (AAE) consensus motif; other site 1126211008197 putative AMP binding site [chemical binding]; other site 1126211008198 putative active site [active] 1126211008199 putative CoA binding site [chemical binding]; other site 1126211008200 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1126211008201 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1126211008202 Predicted membrane protein [Function unknown]; Region: COG3766 1126211008203 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1126211008204 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1126211008205 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1126211008206 MutS domain III; Region: MutS_III; pfam05192 1126211008207 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1126211008208 Walker A/P-loop; other site 1126211008209 ATP binding site [chemical binding]; other site 1126211008210 Q-loop/lid; other site 1126211008211 ABC transporter signature motif; other site 1126211008212 Walker B; other site 1126211008213 D-loop; other site 1126211008214 H-loop/switch region; other site 1126211008215 Smr domain; Region: Smr; pfam01713 1126211008216 hypothetical protein; Provisional; Region: PRK08609 1126211008217 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1126211008218 active site 1126211008219 primer binding site [nucleotide binding]; other site 1126211008220 NTP binding site [chemical binding]; other site 1126211008221 metal binding triad [ion binding]; metal-binding site 1126211008222 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1126211008223 active site 1126211008224 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1126211008225 Colicin V production protein; Region: Colicin_V; pfam02674 1126211008226 cell division protein ZapA; Provisional; Region: PRK14126 1126211008227 ribonuclease HIII; Provisional; Region: PRK00996 1126211008228 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1126211008229 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1126211008230 RNA/DNA hybrid binding site [nucleotide binding]; other site 1126211008231 active site 1126211008232 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1126211008233 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1126211008234 putative tRNA-binding site [nucleotide binding]; other site 1126211008235 B3/4 domain; Region: B3_4; pfam03483 1126211008236 tRNA synthetase B5 domain; Region: B5; smart00874 1126211008237 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1126211008238 dimer interface [polypeptide binding]; other site 1126211008239 motif 1; other site 1126211008240 motif 3; other site 1126211008241 motif 2; other site 1126211008242 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1126211008243 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1126211008244 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1126211008245 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1126211008246 dimer interface [polypeptide binding]; other site 1126211008247 motif 1; other site 1126211008248 active site 1126211008249 motif 2; other site 1126211008250 motif 3; other site 1126211008251 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1126211008252 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1126211008253 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1126211008254 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1126211008255 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1126211008256 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1126211008257 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1126211008258 FAD binding domain; Region: FAD_binding_4; pfam01565 1126211008259 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1126211008260 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1126211008261 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1126211008262 Cysteine-rich domain; Region: CCG; pfam02754 1126211008263 Cysteine-rich domain; Region: CCG; pfam02754 1126211008264 Carbon starvation protein CstA; Region: CstA; pfam02554 1126211008265 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1126211008266 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1126211008267 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1126211008268 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1126211008269 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1126211008270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211008271 putative PBP binding loops; other site 1126211008272 dimer interface [polypeptide binding]; other site 1126211008273 ABC-ATPase subunit interface; other site 1126211008274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211008275 dimer interface [polypeptide binding]; other site 1126211008276 conserved gate region; other site 1126211008277 putative PBP binding loops; other site 1126211008278 ABC-ATPase subunit interface; other site 1126211008279 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1126211008280 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1126211008281 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1126211008282 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1126211008283 active site 1126211008284 metal binding site [ion binding]; metal-binding site 1126211008285 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1126211008286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211008287 active site 1126211008288 motif I; other site 1126211008289 motif II; other site 1126211008290 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211008291 motif II; other site 1126211008292 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1126211008293 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1126211008294 intersubunit interface [polypeptide binding]; other site 1126211008295 active site 1126211008296 Zn2+ binding site [ion binding]; other site 1126211008297 ribulokinase; Provisional; Region: PRK04123 1126211008298 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1126211008299 N- and C-terminal domain interface [polypeptide binding]; other site 1126211008300 active site 1126211008301 MgATP binding site [chemical binding]; other site 1126211008302 catalytic site [active] 1126211008303 metal binding site [ion binding]; metal-binding site 1126211008304 carbohydrate binding site [chemical binding]; other site 1126211008305 homodimer interface [polypeptide binding]; other site 1126211008306 L-arabinose isomerase; Provisional; Region: PRK02929 1126211008307 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1126211008308 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1126211008309 trimer interface [polypeptide binding]; other site 1126211008310 putative substrate binding site [chemical binding]; other site 1126211008311 putative metal binding site [ion binding]; other site 1126211008312 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1126211008313 substrate binding site [chemical binding]; other site 1126211008314 active site 1126211008315 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1126211008316 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1126211008317 oligomer interface [polypeptide binding]; other site 1126211008318 active site 1126211008319 metal binding site [ion binding]; metal-binding site 1126211008320 Predicted integral membrane protein [Function unknown]; Region: COG5615 1126211008321 Predicted membrane protein [Function unknown]; Region: COG3326 1126211008322 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1126211008323 23S rRNA binding site [nucleotide binding]; other site 1126211008324 L21 binding site [polypeptide binding]; other site 1126211008325 L13 binding site [polypeptide binding]; other site 1126211008326 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1126211008327 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1126211008328 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1126211008329 antiholin-like protein LrgB; Provisional; Region: PRK04288 1126211008330 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1126211008331 two-component response regulator; Provisional; Region: PRK14084 1126211008332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211008333 active site 1126211008334 phosphorylation site [posttranslational modification] 1126211008335 intermolecular recognition site; other site 1126211008336 dimerization interface [polypeptide binding]; other site 1126211008337 LytTr DNA-binding domain; Region: LytTR; smart00850 1126211008338 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1126211008339 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1126211008340 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1126211008341 Histidine kinase; Region: His_kinase; pfam06580 1126211008342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211008343 ATP binding site [chemical binding]; other site 1126211008344 Mg2+ binding site [ion binding]; other site 1126211008345 G-X-G motif; other site 1126211008346 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1126211008347 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211008348 motif II; other site 1126211008349 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1126211008350 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1126211008351 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1126211008352 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1126211008353 active site 1126211008354 dimer interface [polypeptide binding]; other site 1126211008355 motif 1; other site 1126211008356 motif 2; other site 1126211008357 motif 3; other site 1126211008358 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1126211008359 anticodon binding site; other site 1126211008360 YtxC-like family; Region: YtxC; pfam08812 1126211008361 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1126211008362 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1126211008363 primosomal protein DnaI; Reviewed; Region: PRK08939 1126211008364 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1126211008365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211008366 Walker A motif; other site 1126211008367 ATP binding site [chemical binding]; other site 1126211008368 Walker B motif; other site 1126211008369 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1126211008370 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1126211008371 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1126211008372 ATP cone domain; Region: ATP-cone; pfam03477 1126211008373 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1126211008374 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1126211008375 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1126211008376 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1126211008377 Predicted transcriptional regulators [Transcription]; Region: COG1733 1126211008378 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1126211008379 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1126211008380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211008381 putative substrate translocation pore; other site 1126211008382 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1126211008383 active site 1126211008384 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1126211008385 catalytic tetrad [active] 1126211008386 dephospho-CoA kinase; Region: TIGR00152 1126211008387 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1126211008388 CoA-binding site [chemical binding]; other site 1126211008389 ATP-binding [chemical binding]; other site 1126211008390 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1126211008391 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1126211008392 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1126211008393 DNA binding site [nucleotide binding] 1126211008394 catalytic residue [active] 1126211008395 H2TH interface [polypeptide binding]; other site 1126211008396 putative catalytic residues [active] 1126211008397 turnover-facilitating residue; other site 1126211008398 intercalation triad [nucleotide binding]; other site 1126211008399 8OG recognition residue [nucleotide binding]; other site 1126211008400 putative reading head residues; other site 1126211008401 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1126211008402 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1126211008403 DNA polymerase I; Provisional; Region: PRK05755 1126211008404 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1126211008405 active site 1126211008406 metal binding site 1 [ion binding]; metal-binding site 1126211008407 putative 5' ssDNA interaction site; other site 1126211008408 metal binding site 3; metal-binding site 1126211008409 metal binding site 2 [ion binding]; metal-binding site 1126211008410 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1126211008411 putative DNA binding site [nucleotide binding]; other site 1126211008412 putative metal binding site [ion binding]; other site 1126211008413 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1126211008414 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1126211008415 active site 1126211008416 DNA binding site [nucleotide binding] 1126211008417 catalytic site [active] 1126211008418 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1126211008419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1126211008420 putative active site [active] 1126211008421 heme pocket [chemical binding]; other site 1126211008422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211008423 dimer interface [polypeptide binding]; other site 1126211008424 phosphorylation site [posttranslational modification] 1126211008425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211008426 ATP binding site [chemical binding]; other site 1126211008427 Mg2+ binding site [ion binding]; other site 1126211008428 G-X-G motif; other site 1126211008429 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211008430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211008431 active site 1126211008432 phosphorylation site [posttranslational modification] 1126211008433 intermolecular recognition site; other site 1126211008434 dimerization interface [polypeptide binding]; other site 1126211008435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211008436 DNA binding site [nucleotide binding] 1126211008437 malate dehydrogenase; Reviewed; Region: PRK06223 1126211008438 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1126211008439 NAD(P) binding site [chemical binding]; other site 1126211008440 dimer interface [polypeptide binding]; other site 1126211008441 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1126211008442 substrate binding site [chemical binding]; other site 1126211008443 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1126211008444 isocitrate dehydrogenase; Validated; Region: PRK07362 1126211008445 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1126211008446 dimer interface [polypeptide binding]; other site 1126211008447 Citrate synthase; Region: Citrate_synt; pfam00285 1126211008448 active site 1126211008449 citrylCoA binding site [chemical binding]; other site 1126211008450 oxalacetate/citrate binding site [chemical binding]; other site 1126211008451 coenzyme A binding site [chemical binding]; other site 1126211008452 catalytic triad [active] 1126211008453 TPR repeat; Region: TPR_11; pfam13414 1126211008454 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211008455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211008456 binding surface 1126211008457 TPR motif; other site 1126211008458 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211008459 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1126211008460 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1126211008461 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1126211008462 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1126211008463 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1126211008464 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1126211008465 pyruvate kinase; Provisional; Region: PRK06354 1126211008466 domain interfaces; other site 1126211008467 active site 1126211008468 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1126211008469 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1126211008470 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1126211008471 active site 1126211008472 ADP/pyrophosphate binding site [chemical binding]; other site 1126211008473 dimerization interface [polypeptide binding]; other site 1126211008474 allosteric effector site; other site 1126211008475 fructose-1,6-bisphosphate binding site; other site 1126211008476 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1126211008477 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1126211008478 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1126211008479 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1126211008480 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1126211008481 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1126211008482 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1126211008483 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1126211008484 putative NAD(P) binding site [chemical binding]; other site 1126211008485 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1126211008486 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1126211008487 active site 1126211008488 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1126211008489 generic binding surface I; other site 1126211008490 generic binding surface II; other site 1126211008491 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1126211008492 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1126211008493 DHH family; Region: DHH; pfam01368 1126211008494 DHHA1 domain; Region: DHHA1; pfam02272 1126211008495 YtpI-like protein; Region: YtpI; pfam14007 1126211008496 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1126211008497 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1126211008498 DNA-binding site [nucleotide binding]; DNA binding site 1126211008499 DRTGG domain; Region: DRTGG; pfam07085 1126211008500 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1126211008501 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1126211008502 active site 2 [active] 1126211008503 active site 1 [active] 1126211008504 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1126211008505 metal-dependent hydrolase; Provisional; Region: PRK00685 1126211008506 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1126211008507 classical (c) SDRs; Region: SDR_c; cd05233 1126211008508 NAD(P) binding site [chemical binding]; other site 1126211008509 active site 1126211008510 argininosuccinate lyase; Provisional; Region: PRK00855 1126211008511 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1126211008512 active sites [active] 1126211008513 tetramer interface [polypeptide binding]; other site 1126211008514 argininosuccinate synthase; Provisional; Region: PRK13820 1126211008515 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1126211008516 ANP binding site [chemical binding]; other site 1126211008517 Substrate Binding Site II [chemical binding]; other site 1126211008518 Substrate Binding Site I [chemical binding]; other site 1126211008519 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1126211008520 MPT binding site; other site 1126211008521 trimer interface [polypeptide binding]; other site 1126211008522 propionate/acetate kinase; Provisional; Region: PRK12379 1126211008523 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1126211008524 nucleotide binding site [chemical binding]; other site 1126211008525 butyrate kinase; Provisional; Region: PRK03011 1126211008526 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1126211008527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211008528 S-adenosylmethionine binding site [chemical binding]; other site 1126211008529 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1126211008530 dimer interface [polypeptide binding]; other site 1126211008531 catalytic triad [active] 1126211008532 peroxidatic and resolving cysteines [active] 1126211008533 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 1126211008534 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1126211008535 RDD family; Region: RDD; pfam06271 1126211008536 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1126211008537 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1126211008538 tandem repeat interface [polypeptide binding]; other site 1126211008539 oligomer interface [polypeptide binding]; other site 1126211008540 active site residues [active] 1126211008541 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1126211008542 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1126211008543 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1126211008544 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1126211008545 active site 1126211008546 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1126211008547 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1126211008548 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1126211008549 active site 1126211008550 acyl-activating enzyme (AAE) consensus motif; other site 1126211008551 putative CoA binding site [chemical binding]; other site 1126211008552 AMP binding site [chemical binding]; other site 1126211008553 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1126211008554 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1126211008555 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1126211008556 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1126211008557 Ligand Binding Site [chemical binding]; other site 1126211008558 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1126211008559 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1126211008560 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1126211008561 catalytic residue [active] 1126211008562 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1126211008563 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1126211008564 TMPIT-like protein; Region: TMPIT; pfam07851 1126211008565 histidinol-phosphatase; Reviewed; Region: PRK08123 1126211008566 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1126211008567 active site 1126211008568 dimer interface [polypeptide binding]; other site 1126211008569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211008570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211008571 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1126211008572 GAF domain; Region: GAF_2; pfam13185 1126211008573 GAF domain; Region: GAF_3; pfam13492 1126211008574 GAF domain; Region: GAF_2; pfam13185 1126211008575 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1126211008576 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1126211008577 metal binding site [ion binding]; metal-binding site 1126211008578 active site 1126211008579 I-site; other site 1126211008580 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1126211008581 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1126211008582 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1126211008583 RNA binding surface [nucleotide binding]; other site 1126211008584 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1126211008585 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1126211008586 NAD(P) binding site [chemical binding]; other site 1126211008587 catalytic residues [active] 1126211008588 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1126211008589 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1126211008590 active site 1126211008591 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1126211008592 positive control sigma-like factor; Validated; Region: PRK06930 1126211008593 DNA binding residues [nucleotide binding] 1126211008594 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1126211008595 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1126211008596 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1126211008597 heme-binding site [chemical binding]; other site 1126211008598 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1126211008599 FAD binding pocket [chemical binding]; other site 1126211008600 FAD binding motif [chemical binding]; other site 1126211008601 phosphate binding motif [ion binding]; other site 1126211008602 beta-alpha-beta structure motif; other site 1126211008603 NAD binding pocket [chemical binding]; other site 1126211008604 Heme binding pocket [chemical binding]; other site 1126211008605 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1126211008606 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1126211008607 proposed catalytic triad [active] 1126211008608 conserved cys residue [active] 1126211008609 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1126211008610 active site 1126211008611 catalytic triad [active] 1126211008612 oxyanion hole [active] 1126211008613 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1126211008614 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1126211008615 Predicted transcriptional regulators [Transcription]; Region: COG1378 1126211008616 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1126211008617 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1126211008618 C-terminal domain interface [polypeptide binding]; other site 1126211008619 sugar binding site [chemical binding]; other site 1126211008620 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1126211008621 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1126211008622 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1126211008623 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1126211008624 active site 1126211008625 HIGH motif; other site 1126211008626 dimer interface [polypeptide binding]; other site 1126211008627 KMSKS motif; other site 1126211008628 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1126211008629 RNA binding surface [nucleotide binding]; other site 1126211008630 acetyl-CoA synthetase; Provisional; Region: PRK04319 1126211008631 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1126211008632 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1126211008633 active site 1126211008634 acyl-activating enzyme (AAE) consensus motif; other site 1126211008635 putative CoA binding site [chemical binding]; other site 1126211008636 AMP binding site [chemical binding]; other site 1126211008637 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211008638 Coenzyme A binding pocket [chemical binding]; other site 1126211008639 FOG: CBS domain [General function prediction only]; Region: COG0517 1126211008640 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1126211008641 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1126211008642 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1126211008643 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1126211008644 active site 1126211008645 Zn binding site [ion binding]; other site 1126211008646 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1126211008647 flagellar motor protein MotS; Reviewed; Region: PRK06925 1126211008648 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1126211008649 ligand binding site [chemical binding]; other site 1126211008650 flagellar motor protein MotP; Reviewed; Region: PRK06926 1126211008651 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1126211008652 catabolite control protein A; Region: ccpA; TIGR01481 1126211008653 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1126211008654 DNA binding site [nucleotide binding] 1126211008655 domain linker motif; other site 1126211008656 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1126211008657 dimerization interface [polypeptide binding]; other site 1126211008658 effector binding site; other site 1126211008659 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1126211008660 Chorismate mutase type II; Region: CM_2; cl00693 1126211008661 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1126211008662 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1126211008663 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1126211008664 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1126211008665 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1126211008666 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1126211008667 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1126211008668 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1126211008669 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1126211008670 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1126211008671 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1126211008672 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1126211008673 putative tRNA-binding site [nucleotide binding]; other site 1126211008674 hypothetical protein; Provisional; Region: PRK13668 1126211008675 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1126211008676 catalytic residues [active] 1126211008677 YtoQ family protein; Region: YtoQ_fam; TIGR03646 1126211008678 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1126211008679 CGNR zinc finger; Region: zf-CGNR; pfam11706 1126211008680 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1126211008681 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1126211008682 oligomer interface [polypeptide binding]; other site 1126211008683 active site 1126211008684 metal binding site [ion binding]; metal-binding site 1126211008685 Predicted small secreted protein [Function unknown]; Region: COG5584 1126211008686 malate dehydrogenase; Provisional; Region: PRK13529 1126211008687 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1126211008688 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1126211008689 NAD(P) binding site [chemical binding]; other site 1126211008690 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1126211008691 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211008692 S-adenosylmethionine binding site [chemical binding]; other site 1126211008693 YtzH-like protein; Region: YtzH; pfam14165 1126211008694 Phosphotransferase enzyme family; Region: APH; pfam01636 1126211008695 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1126211008696 active site 1126211008697 ATP binding site [chemical binding]; other site 1126211008698 substrate binding site [chemical binding]; other site 1126211008699 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1126211008700 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1126211008701 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1126211008702 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1126211008703 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1126211008704 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1126211008705 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1126211008706 dimer interface [polypeptide binding]; other site 1126211008707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211008708 catalytic residue [active] 1126211008709 dipeptidase PepV; Reviewed; Region: PRK07318 1126211008710 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1126211008711 active site 1126211008712 metal binding site [ion binding]; metal-binding site 1126211008713 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1126211008714 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1126211008715 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1126211008716 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1126211008717 Walker A/P-loop; other site 1126211008718 ATP binding site [chemical binding]; other site 1126211008719 Q-loop/lid; other site 1126211008720 ABC transporter signature motif; other site 1126211008721 Walker B; other site 1126211008722 D-loop; other site 1126211008723 H-loop/switch region; other site 1126211008724 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1126211008725 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1126211008726 RNA binding surface [nucleotide binding]; other site 1126211008727 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1126211008728 active site 1126211008729 uracil binding [chemical binding]; other site 1126211008730 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1126211008731 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1126211008732 HI0933-like protein; Region: HI0933_like; pfam03486 1126211008733 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1126211008734 BCCT family transporter; Region: BCCT; pfam02028 1126211008735 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1126211008736 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1126211008737 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1126211008738 DNA binding site [nucleotide binding] 1126211008739 domain linker motif; other site 1126211008740 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1126211008741 putative ligand binding site [chemical binding]; other site 1126211008742 putative dimerization interface [polypeptide binding]; other site 1126211008743 PBP superfamily domain; Region: PBP_like_2; cl17296 1126211008744 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1126211008745 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1126211008746 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1126211008747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211008748 dimer interface [polypeptide binding]; other site 1126211008749 conserved gate region; other site 1126211008750 putative PBP binding loops; other site 1126211008751 ABC-ATPase subunit interface; other site 1126211008752 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1126211008753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211008754 dimer interface [polypeptide binding]; other site 1126211008755 conserved gate region; other site 1126211008756 putative PBP binding loops; other site 1126211008757 ABC-ATPase subunit interface; other site 1126211008758 alpha-galactosidase; Provisional; Region: PRK15076 1126211008759 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1126211008760 NAD binding site [chemical binding]; other site 1126211008761 sugar binding site [chemical binding]; other site 1126211008762 divalent metal binding site [ion binding]; other site 1126211008763 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1126211008764 dimer interface [polypeptide binding]; other site 1126211008765 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1126211008766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211008767 Coenzyme A binding pocket [chemical binding]; other site 1126211008768 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1126211008769 active site residue [active] 1126211008770 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1126211008771 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1126211008772 HIGH motif; other site 1126211008773 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1126211008774 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1126211008775 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1126211008776 active site 1126211008777 KMSKS motif; other site 1126211008778 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1126211008779 tRNA binding surface [nucleotide binding]; other site 1126211008780 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1126211008781 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1126211008782 PAS domain; Region: PAS_9; pfam13426 1126211008783 putative active site [active] 1126211008784 heme pocket [chemical binding]; other site 1126211008785 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1126211008786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211008787 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211008788 putative substrate translocation pore; other site 1126211008789 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 1126211008790 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1126211008791 FtsX-like permease family; Region: FtsX; pfam02687 1126211008792 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1126211008793 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1126211008794 Walker A/P-loop; other site 1126211008795 ATP binding site [chemical binding]; other site 1126211008796 Q-loop/lid; other site 1126211008797 ABC transporter signature motif; other site 1126211008798 Walker B; other site 1126211008799 D-loop; other site 1126211008800 H-loop/switch region; other site 1126211008801 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211008802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211008803 ATP binding site [chemical binding]; other site 1126211008804 Mg2+ binding site [ion binding]; other site 1126211008805 G-X-G motif; other site 1126211008806 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211008807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211008808 active site 1126211008809 phosphorylation site [posttranslational modification] 1126211008810 intermolecular recognition site; other site 1126211008811 dimerization interface [polypeptide binding]; other site 1126211008812 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211008813 DNA binding site [nucleotide binding] 1126211008814 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1126211008815 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1126211008816 FtsX-like permease family; Region: FtsX; pfam02687 1126211008817 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1126211008818 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1126211008819 Walker A/P-loop; other site 1126211008820 ATP binding site [chemical binding]; other site 1126211008821 Q-loop/lid; other site 1126211008822 ABC transporter signature motif; other site 1126211008823 Walker B; other site 1126211008824 D-loop; other site 1126211008825 H-loop/switch region; other site 1126211008826 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1126211008827 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1126211008828 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1126211008829 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1126211008830 Walker A/P-loop; other site 1126211008831 ATP binding site [chemical binding]; other site 1126211008832 Q-loop/lid; other site 1126211008833 ABC transporter signature motif; other site 1126211008834 Walker B; other site 1126211008835 D-loop; other site 1126211008836 H-loop/switch region; other site 1126211008837 Predicted transcriptional regulators [Transcription]; Region: COG1725 1126211008838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211008839 DNA-binding site [nucleotide binding]; DNA binding site 1126211008840 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1126211008841 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1126211008842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211008843 S-adenosylmethionine binding site [chemical binding]; other site 1126211008844 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1126211008845 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1126211008846 active site 1126211008847 catalytic site [active] 1126211008848 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1126211008849 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1126211008850 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1126211008851 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1126211008852 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1126211008853 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1126211008854 trimer interface [polypeptide binding]; other site 1126211008855 putative metal binding site [ion binding]; other site 1126211008856 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1126211008857 Spore germination protein; Region: Spore_permease; cl17796 1126211008858 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1126211008859 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1126211008860 active site 1126211008861 dimer interface [polypeptide binding]; other site 1126211008862 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1126211008863 Ligand Binding Site [chemical binding]; other site 1126211008864 Molecular Tunnel; other site 1126211008865 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1126211008866 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1126211008867 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1126211008868 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1126211008869 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1126211008870 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1126211008871 active site 1126211008872 substrate-binding site [chemical binding]; other site 1126211008873 metal-binding site [ion binding] 1126211008874 ATP binding site [chemical binding]; other site 1126211008875 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1126211008876 Dienelactone hydrolase family; Region: DLH; pfam01738 1126211008877 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1126211008878 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1126211008879 NMT1-like family; Region: NMT1_2; pfam13379 1126211008880 substrate binding pocket [chemical binding]; other site 1126211008881 membrane-bound complex binding site; other site 1126211008882 hinge residues; other site 1126211008883 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1126211008884 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1126211008885 Walker A/P-loop; other site 1126211008886 ATP binding site [chemical binding]; other site 1126211008887 Q-loop/lid; other site 1126211008888 ABC transporter signature motif; other site 1126211008889 Walker B; other site 1126211008890 D-loop; other site 1126211008891 H-loop/switch region; other site 1126211008892 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1126211008893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211008894 dimer interface [polypeptide binding]; other site 1126211008895 conserved gate region; other site 1126211008896 putative PBP binding loops; other site 1126211008897 ABC-ATPase subunit interface; other site 1126211008898 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1126211008899 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1126211008900 nudix motif; other site 1126211008901 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1126211008902 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1126211008903 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1126211008904 dimerization interface [polypeptide binding]; other site 1126211008905 DPS ferroxidase diiron center [ion binding]; other site 1126211008906 ion pore; other site 1126211008907 YtkA-like; Region: YtkA; pfam13115 1126211008908 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1126211008909 Haemolytic domain; Region: Haemolytic; pfam01809 1126211008910 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1126211008911 active site clefts [active] 1126211008912 zinc binding site [ion binding]; other site 1126211008913 dimer interface [polypeptide binding]; other site 1126211008914 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1126211008915 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1126211008916 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1126211008917 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1126211008918 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1126211008919 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1126211008920 ABC-ATPase subunit interface; other site 1126211008921 dimer interface [polypeptide binding]; other site 1126211008922 putative PBP binding regions; other site 1126211008923 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1126211008924 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1126211008925 ABC-ATPase subunit interface; other site 1126211008926 dimer interface [polypeptide binding]; other site 1126211008927 putative PBP binding regions; other site 1126211008928 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1126211008929 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1126211008930 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1126211008931 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1126211008932 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 1126211008933 metal binding site [ion binding]; metal-binding site 1126211008934 intersubunit interface [polypeptide binding]; other site 1126211008935 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1126211008936 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1126211008937 active site 1126211008938 octamer interface [polypeptide binding]; other site 1126211008939 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1126211008940 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1126211008941 acyl-activating enzyme (AAE) consensus motif; other site 1126211008942 putative AMP binding site [chemical binding]; other site 1126211008943 putative active site [active] 1126211008944 putative CoA binding site [chemical binding]; other site 1126211008945 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1126211008946 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1126211008947 substrate binding site [chemical binding]; other site 1126211008948 oxyanion hole (OAH) forming residues; other site 1126211008949 trimer interface [polypeptide binding]; other site 1126211008950 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1126211008951 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1126211008952 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1126211008953 dimer interface [polypeptide binding]; other site 1126211008954 tetramer interface [polypeptide binding]; other site 1126211008955 PYR/PP interface [polypeptide binding]; other site 1126211008956 TPP binding site [chemical binding]; other site 1126211008957 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1126211008958 TPP-binding site; other site 1126211008959 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1126211008960 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1126211008961 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1126211008962 TspO/MBR family; Region: TspO_MBR; cl01379 1126211008963 Predicted membrane protein [Function unknown]; Region: COG3859 1126211008964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1126211008965 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1126211008966 DinB superfamily; Region: DinB_2; pfam12867 1126211008967 DinB family; Region: DinB; cl17821 1126211008968 MOSC domain; Region: MOSC; pfam03473 1126211008969 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1126211008970 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1126211008971 active site 1126211008972 NAD binding site [chemical binding]; other site 1126211008973 metal binding site [ion binding]; metal-binding site 1126211008974 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1126211008975 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1126211008976 tetramerization interface [polypeptide binding]; other site 1126211008977 NAD(P) binding site [chemical binding]; other site 1126211008978 catalytic residues [active] 1126211008979 Predicted transcriptional regulators [Transcription]; Region: COG1510 1126211008980 MarR family; Region: MarR_2; pfam12802 1126211008981 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1126211008982 TrkA-N domain; Region: TrkA_N; pfam02254 1126211008983 TrkA-C domain; Region: TrkA_C; pfam02080 1126211008984 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1126211008985 SH3-like domain; Region: SH3_8; pfam13457 1126211008986 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1126211008987 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1126211008988 heme-binding site [chemical binding]; other site 1126211008989 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1126211008990 FAD binding pocket [chemical binding]; other site 1126211008991 FAD binding motif [chemical binding]; other site 1126211008992 phosphate binding motif [ion binding]; other site 1126211008993 beta-alpha-beta structure motif; other site 1126211008994 NAD binding pocket [chemical binding]; other site 1126211008995 Heme binding pocket [chemical binding]; other site 1126211008996 Cupin; Region: Cupin_1; smart00835 1126211008997 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1126211008998 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1126211008999 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1126211009000 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1126211009001 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1126211009002 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1126211009003 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1126211009004 proposed catalytic triad [active] 1126211009005 conserved cys residue [active] 1126211009006 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1126211009007 Cache domain; Region: Cache_1; pfam02743 1126211009008 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1126211009009 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1126211009010 dimerization interface [polypeptide binding]; other site 1126211009011 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1126211009012 dimer interface [polypeptide binding]; other site 1126211009013 putative CheW interface [polypeptide binding]; other site 1126211009014 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1126211009015 Cache domain; Region: Cache_1; pfam02743 1126211009016 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1126211009017 dimerization interface [polypeptide binding]; other site 1126211009018 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1126211009019 dimer interface [polypeptide binding]; other site 1126211009020 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1126211009021 putative CheW interface [polypeptide binding]; other site 1126211009022 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1126211009023 dimer interface [polypeptide binding]; other site 1126211009024 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1126211009025 putative CheW interface [polypeptide binding]; other site 1126211009026 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1126211009027 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1126211009028 Cache domain; Region: Cache_1; pfam02743 1126211009029 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1126211009030 dimerization interface [polypeptide binding]; other site 1126211009031 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1126211009032 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1126211009033 dimer interface [polypeptide binding]; other site 1126211009034 putative CheW interface [polypeptide binding]; other site 1126211009035 transglutaminase; Provisional; Region: tgl; PRK03187 1126211009036 potential frameshift: common BLAST hit: gi|384169763|ref|YP_005551141.1| putative 2-nitropropane dioxygenase 1126211009037 Nitronate monooxygenase; Region: NMO; pfam03060 1126211009038 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1126211009039 FMN binding site [chemical binding]; other site 1126211009040 substrate binding site [chemical binding]; other site 1126211009041 putative catalytic residue [active] 1126211009042 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1126211009043 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1126211009044 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1126211009045 Ca binding site [ion binding]; other site 1126211009046 active site 1126211009047 catalytic site [active] 1126211009048 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1126211009049 Transporter associated domain; Region: CorC_HlyC; smart01091 1126211009050 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1126211009051 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1126211009052 Ion channel; Region: Ion_trans_2; pfam07885 1126211009053 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1126211009054 TrkA-N domain; Region: TrkA_N; pfam02254 1126211009055 YugN-like family; Region: YugN; pfam08868 1126211009056 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1126211009057 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1126211009058 active site 1126211009059 dimer interface [polypeptide binding]; other site 1126211009060 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1126211009061 dimer interface [polypeptide binding]; other site 1126211009062 active site 1126211009063 Predicted flavoprotein [General function prediction only]; Region: COG0431 1126211009064 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1126211009065 Isochorismatase family; Region: Isochorismatase; pfam00857 1126211009066 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1126211009067 catalytic triad [active] 1126211009068 dimer interface [polypeptide binding]; other site 1126211009069 conserved cis-peptide bond; other site 1126211009070 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1126211009071 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1126211009072 dimer interface [polypeptide binding]; other site 1126211009073 active site 1126211009074 metal binding site [ion binding]; metal-binding site 1126211009075 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1126211009076 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1126211009077 dimer interface [polypeptide binding]; other site 1126211009078 active site 1126211009079 metal binding site [ion binding]; metal-binding site 1126211009080 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1126211009081 general stress protein 13; Validated; Region: PRK08059 1126211009082 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1126211009083 RNA binding site [nucleotide binding]; other site 1126211009084 hypothetical protein; Validated; Region: PRK07682 1126211009085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211009086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211009087 homodimer interface [polypeptide binding]; other site 1126211009088 catalytic residue [active] 1126211009089 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1126211009090 AsnC family; Region: AsnC_trans_reg; pfam01037 1126211009091 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1126211009092 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1126211009093 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1126211009094 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1126211009095 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211009096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211009097 homodimer interface [polypeptide binding]; other site 1126211009098 catalytic residue [active] 1126211009099 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211009100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211009101 dimer interface [polypeptide binding]; other site 1126211009102 phosphorylation site [posttranslational modification] 1126211009103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211009104 ATP binding site [chemical binding]; other site 1126211009105 Mg2+ binding site [ion binding]; other site 1126211009106 G-X-G motif; other site 1126211009107 Kinase associated protein B; Region: KapB; pfam08810 1126211009108 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1126211009109 active site 1126211009110 catalytic site [active] 1126211009111 substrate binding site [chemical binding]; other site 1126211009112 drug efflux system protein MdtG; Provisional; Region: PRK09874 1126211009113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211009114 putative substrate translocation pore; other site 1126211009115 Transglycosylase; Region: Transgly; pfam00912 1126211009116 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1126211009117 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1126211009118 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1126211009119 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1126211009120 PAS domain; Region: PAS; smart00091 1126211009121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211009122 ATP binding site [chemical binding]; other site 1126211009123 Mg2+ binding site [ion binding]; other site 1126211009124 G-X-G motif; other site 1126211009125 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1126211009126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211009127 active site 1126211009128 phosphorylation site [posttranslational modification] 1126211009129 intermolecular recognition site; other site 1126211009130 dimerization interface [polypeptide binding]; other site 1126211009131 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1126211009132 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1126211009133 ligand binding site [chemical binding]; other site 1126211009134 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1126211009135 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1126211009136 Walker A/P-loop; other site 1126211009137 ATP binding site [chemical binding]; other site 1126211009138 Q-loop/lid; other site 1126211009139 ABC transporter signature motif; other site 1126211009140 Walker B; other site 1126211009141 D-loop; other site 1126211009142 H-loop/switch region; other site 1126211009143 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1126211009144 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1126211009145 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1126211009146 TM-ABC transporter signature motif; other site 1126211009147 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1126211009148 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1126211009149 TM-ABC transporter signature motif; other site 1126211009150 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1126211009151 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1126211009152 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1126211009153 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1126211009154 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1126211009155 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1126211009156 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1126211009157 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1126211009158 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1126211009159 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1126211009160 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1126211009161 CoenzymeA binding site [chemical binding]; other site 1126211009162 subunit interaction site [polypeptide binding]; other site 1126211009163 PHB binding site; other site 1126211009164 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1126211009165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211009166 active site 1126211009167 phosphorylation site [posttranslational modification] 1126211009168 intermolecular recognition site; other site 1126211009169 dimerization interface [polypeptide binding]; other site 1126211009170 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1126211009171 DNA binding residues [nucleotide binding] 1126211009172 dimerization interface [polypeptide binding]; other site 1126211009173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1126211009174 Histidine kinase; Region: HisKA_3; pfam07730 1126211009175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211009176 ATP binding site [chemical binding]; other site 1126211009177 Mg2+ binding site [ion binding]; other site 1126211009178 G-X-G motif; other site 1126211009179 Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867 1126211009180 substrate-Mg2+ binding site; other site 1126211009181 aspartate-rich region 2; other site 1126211009182 DegQ (SacQ) family; Region: DegQ; pfam08181 1126211009183 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1126211009184 EAL domain; Region: EAL; pfam00563 1126211009185 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1126211009186 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1126211009187 active site 1126211009188 Isochorismatase family; Region: Isochorismatase; pfam00857 1126211009189 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1126211009190 catalytic triad [active] 1126211009191 conserved cis-peptide bond; other site 1126211009192 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1126211009193 YueH-like protein; Region: YueH; pfam14166 1126211009194 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1126211009195 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1126211009196 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1126211009197 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1126211009198 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1126211009199 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1126211009200 Zn2+ binding site [ion binding]; other site 1126211009201 Mg2+ binding site [ion binding]; other site 1126211009202 short chain dehydrogenase; Provisional; Region: PRK06924 1126211009203 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1126211009204 NADP binding site [chemical binding]; other site 1126211009205 homodimer interface [polypeptide binding]; other site 1126211009206 active site 1126211009207 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1126211009208 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1126211009209 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1126211009210 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1126211009211 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1126211009212 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1126211009213 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1126211009214 Domain of unknown function DUF87; Region: DUF87; pfam01935 1126211009215 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1126211009216 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 1126211009217 Uncharacterized small protein [Function unknown]; Region: COG5417 1126211009218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1126211009219 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1126211009220 CodY GAF-like domain; Region: CodY; pfam06018 1126211009221 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1126211009222 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1126211009223 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1126211009224 hexamer interface [polypeptide binding]; other site 1126211009225 ligand binding site [chemical binding]; other site 1126211009226 putative active site [active] 1126211009227 NAD(P) binding site [chemical binding]; other site 1126211009228 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1126211009229 MbtH-like protein; Region: MbtH; cl01279 1126211009230 Condensation domain; Region: Condensation; pfam00668 1126211009231 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211009232 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1126211009233 acyl-activating enzyme (AAE) consensus motif; other site 1126211009234 AMP binding site [chemical binding]; other site 1126211009235 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211009236 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1126211009237 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211009238 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211009239 acyl-activating enzyme (AAE) consensus motif; other site 1126211009240 AMP binding site [chemical binding]; other site 1126211009241 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211009242 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1126211009243 hydrophobic substrate binding pocket; other site 1126211009244 Isochorismatase family; Region: Isochorismatase; pfam00857 1126211009245 active site 1126211009246 conserved cis-peptide bond; other site 1126211009247 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1126211009248 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1126211009249 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1126211009250 acyl-activating enzyme (AAE) consensus motif; other site 1126211009251 active site 1126211009252 AMP binding site [chemical binding]; other site 1126211009253 substrate binding site [chemical binding]; other site 1126211009254 isochorismate synthase DhbC; Validated; Region: PRK06923 1126211009255 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1126211009256 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1126211009257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1126211009258 NAD(P) binding site [chemical binding]; other site 1126211009259 active site 1126211009260 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1126211009261 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1126211009262 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1126211009263 Moco binding site; other site 1126211009264 metal coordination site [ion binding]; other site 1126211009265 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1126211009266 Predicted permease [General function prediction only]; Region: COG2056 1126211009267 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1126211009268 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1126211009269 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1126211009270 interface (dimer of trimers) [polypeptide binding]; other site 1126211009271 Substrate-binding/catalytic site; other site 1126211009272 Zn-binding sites [ion binding]; other site 1126211009273 Divergent PAP2 family; Region: DUF212; pfam02681 1126211009274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1126211009275 Putative membrane protein; Region: YuiB; pfam14068 1126211009276 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 1126211009277 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1126211009278 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1126211009279 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1126211009280 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1126211009281 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1126211009282 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1126211009283 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1126211009284 active site 1126211009285 Integral membrane protein DUF95; Region: DUF95; pfam01944 1126211009286 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1126211009287 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1126211009288 Walker A/P-loop; other site 1126211009289 ATP binding site [chemical binding]; other site 1126211009290 Q-loop/lid; other site 1126211009291 ABC transporter signature motif; other site 1126211009292 Walker B; other site 1126211009293 D-loop; other site 1126211009294 H-loop/switch region; other site 1126211009295 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1126211009296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1126211009297 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1126211009298 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1126211009299 putative NAD(P) binding site [chemical binding]; other site 1126211009300 active site 1126211009301 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1126211009302 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1126211009303 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1126211009304 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1126211009305 hypothetical protein; Provisional; Region: PRK13669 1126211009306 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1126211009307 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1126211009308 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 1126211009309 NifU-like domain; Region: NifU; pfam01106 1126211009310 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1126211009311 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1126211009312 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1126211009313 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1126211009314 homoserine kinase; Provisional; Region: PRK01212 1126211009315 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1126211009316 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1126211009317 threonine synthase; Reviewed; Region: PRK06721 1126211009318 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1126211009319 homodimer interface [polypeptide binding]; other site 1126211009320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211009321 catalytic residue [active] 1126211009322 homoserine dehydrogenase; Provisional; Region: PRK06349 1126211009323 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1126211009324 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1126211009325 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1126211009326 spore coat protein YutH; Region: spore_yutH; TIGR02905 1126211009327 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1126211009328 tetramer interfaces [polypeptide binding]; other site 1126211009329 binuclear metal-binding site [ion binding]; other site 1126211009330 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1126211009331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211009332 active site 1126211009333 motif I; other site 1126211009334 motif II; other site 1126211009335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211009336 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1126211009337 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1126211009338 lipoyl synthase; Provisional; Region: PRK05481 1126211009339 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1126211009340 FeS/SAM binding site; other site 1126211009341 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1126211009342 Peptidase family M23; Region: Peptidase_M23; pfam01551 1126211009343 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1126211009344 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1126211009345 active site 1126211009346 metal binding site [ion binding]; metal-binding site 1126211009347 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1126211009348 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1126211009349 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1126211009350 allantoinase; Provisional; Region: PRK06189 1126211009351 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1126211009352 active site 1126211009353 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1126211009354 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1126211009355 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1126211009356 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211009357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211009358 binding surface 1126211009359 TPR motif; other site 1126211009360 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211009361 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211009362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211009363 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211009364 putative substrate translocation pore; other site 1126211009365 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1126211009366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1126211009367 catalytic residue [active] 1126211009368 allantoate amidohydrolase; Reviewed; Region: PRK09290 1126211009369 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1126211009370 active site 1126211009371 metal binding site [ion binding]; metal-binding site 1126211009372 dimer interface [polypeptide binding]; other site 1126211009373 Endonuclease I; Region: Endonuclease_1; pfam04231 1126211009374 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1126211009375 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1126211009376 Walker A/P-loop; other site 1126211009377 ATP binding site [chemical binding]; other site 1126211009378 Q-loop/lid; other site 1126211009379 ABC transporter signature motif; other site 1126211009380 Walker B; other site 1126211009381 D-loop; other site 1126211009382 H-loop/switch region; other site 1126211009383 TOBE domain; Region: TOBE_2; pfam08402 1126211009384 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1126211009385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211009386 DNA-binding site [nucleotide binding]; DNA binding site 1126211009387 UTRA domain; Region: UTRA; pfam07702 1126211009388 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1126211009389 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1126211009390 substrate binding site [chemical binding]; other site 1126211009391 ATP binding site [chemical binding]; other site 1126211009392 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1126211009393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211009394 dimer interface [polypeptide binding]; other site 1126211009395 conserved gate region; other site 1126211009396 putative PBP binding loops; other site 1126211009397 ABC-ATPase subunit interface; other site 1126211009398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211009399 dimer interface [polypeptide binding]; other site 1126211009400 conserved gate region; other site 1126211009401 putative PBP binding loops; other site 1126211009402 ABC-ATPase subunit interface; other site 1126211009403 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1126211009404 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1126211009405 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1126211009406 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1126211009407 putative active site [active] 1126211009408 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1126211009409 dimer interface [polypeptide binding]; other site 1126211009410 active site 1126211009411 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1126211009412 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1126211009413 DNA binding residues [nucleotide binding] 1126211009414 dimer interface [polypeptide binding]; other site 1126211009415 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1126211009416 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1126211009417 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 1126211009418 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1126211009419 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1126211009420 GIY-YIG motif/motif A; other site 1126211009421 active site 1126211009422 catalytic site [active] 1126211009423 putative DNA binding site [nucleotide binding]; other site 1126211009424 metal binding site [ion binding]; metal-binding site 1126211009425 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1126211009426 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1126211009427 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1126211009428 chitosan binding site [chemical binding]; other site 1126211009429 catalytic residues [active] 1126211009430 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1126211009431 FeS assembly protein SufB; Region: sufB; TIGR01980 1126211009432 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1126211009433 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1126211009434 trimerization site [polypeptide binding]; other site 1126211009435 active site 1126211009436 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1126211009437 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1126211009438 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1126211009439 catalytic residue [active] 1126211009440 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1126211009441 FeS assembly protein SufD; Region: sufD; TIGR01981 1126211009442 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1126211009443 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1126211009444 Walker A/P-loop; other site 1126211009445 ATP binding site [chemical binding]; other site 1126211009446 Q-loop/lid; other site 1126211009447 ABC transporter signature motif; other site 1126211009448 Walker B; other site 1126211009449 D-loop; other site 1126211009450 H-loop/switch region; other site 1126211009451 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1126211009452 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1126211009453 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1126211009454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211009455 ABC-ATPase subunit interface; other site 1126211009456 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1126211009457 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1126211009458 Walker A/P-loop; other site 1126211009459 ATP binding site [chemical binding]; other site 1126211009460 Q-loop/lid; other site 1126211009461 ABC transporter signature motif; other site 1126211009462 Walker B; other site 1126211009463 D-loop; other site 1126211009464 H-loop/switch region; other site 1126211009465 NIL domain; Region: NIL; pfam09383 1126211009466 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1126211009467 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1126211009468 catalytic residues [active] 1126211009469 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1126211009470 putative active site [active] 1126211009471 putative metal binding site [ion binding]; other site 1126211009472 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1126211009473 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1126211009474 lipoyl attachment site [posttranslational modification]; other site 1126211009475 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1126211009476 ArsC family; Region: ArsC; pfam03960 1126211009477 putative ArsC-like catalytic residues; other site 1126211009478 putative TRX-like catalytic residues [active] 1126211009479 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1126211009480 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1126211009481 active site 1126211009482 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1126211009483 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1126211009484 dimer interface [polypeptide binding]; other site 1126211009485 active site 1126211009486 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1126211009487 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1126211009488 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1126211009489 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1126211009490 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1126211009491 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1126211009492 substrate binding site [chemical binding]; other site 1126211009493 oxyanion hole (OAH) forming residues; other site 1126211009494 trimer interface [polypeptide binding]; other site 1126211009495 YuzL-like protein; Region: YuzL; pfam14115 1126211009496 Coat F domain; Region: Coat_F; pfam07875 1126211009497 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211009498 MarR family; Region: MarR; pfam01047 1126211009499 MarR family; Region: MarR_2; cl17246 1126211009500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211009501 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211009502 putative substrate translocation pore; other site 1126211009503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211009504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1126211009505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1126211009506 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1126211009507 dimerization interface [polypeptide binding]; other site 1126211009508 acetoacetate decarboxylase; Provisional; Region: PRK02265 1126211009509 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1126211009510 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1126211009511 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1126211009512 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1126211009513 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1126211009514 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1126211009515 Walker A/P-loop; other site 1126211009516 ATP binding site [chemical binding]; other site 1126211009517 Q-loop/lid; other site 1126211009518 ABC transporter signature motif; other site 1126211009519 Walker B; other site 1126211009520 D-loop; other site 1126211009521 H-loop/switch region; other site 1126211009522 YusW-like protein; Region: YusW; pfam14039 1126211009523 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1126211009524 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1126211009525 active site 1126211009526 Zn binding site [ion binding]; other site 1126211009527 short chain dehydrogenase; Provisional; Region: PRK06914 1126211009528 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1126211009529 NADP binding site [chemical binding]; other site 1126211009530 active site 1126211009531 steroid binding site; other site 1126211009532 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1126211009533 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1126211009534 dimerization interface [polypeptide binding]; other site 1126211009535 DPS ferroxidase diiron center [ion binding]; other site 1126211009536 ion pore; other site 1126211009537 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211009538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211009539 active site 1126211009540 phosphorylation site [posttranslational modification] 1126211009541 intermolecular recognition site; other site 1126211009542 dimerization interface [polypeptide binding]; other site 1126211009543 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211009544 DNA binding site [nucleotide binding] 1126211009545 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211009546 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1126211009547 dimerization interface [polypeptide binding]; other site 1126211009548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211009549 dimer interface [polypeptide binding]; other site 1126211009550 phosphorylation site [posttranslational modification] 1126211009551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211009552 ATP binding site [chemical binding]; other site 1126211009553 Mg2+ binding site [ion binding]; other site 1126211009554 G-X-G motif; other site 1126211009555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211009556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211009557 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1126211009558 Class II fumarases; Region: Fumarase_classII; cd01362 1126211009559 active site 1126211009560 tetramer interface [polypeptide binding]; other site 1126211009561 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1126211009562 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1126211009563 Spore germination protein; Region: Spore_permease; pfam03845 1126211009564 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1126211009565 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1126211009566 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1126211009567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211009568 active site 1126211009569 phosphorylation site [posttranslational modification] 1126211009570 intermolecular recognition site; other site 1126211009571 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1126211009572 DNA binding residues [nucleotide binding] 1126211009573 dimerization interface [polypeptide binding]; other site 1126211009574 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1126211009575 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1126211009576 dimerization interface [polypeptide binding]; other site 1126211009577 Histidine kinase; Region: HisKA_3; pfam07730 1126211009578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211009579 ATP binding site [chemical binding]; other site 1126211009580 Mg2+ binding site [ion binding]; other site 1126211009581 G-X-G motif; other site 1126211009582 Predicted membrane protein [Function unknown]; Region: COG4758 1126211009583 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1126211009584 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1126211009585 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1126211009586 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1126211009587 PspA/IM30 family; Region: PspA_IM30; pfam04012 1126211009588 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1126211009589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211009590 H+ Antiporter protein; Region: 2A0121; TIGR00900 1126211009591 putative substrate translocation pore; other site 1126211009592 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1126211009593 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1126211009594 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1126211009595 Walker A/P-loop; other site 1126211009596 ATP binding site [chemical binding]; other site 1126211009597 Q-loop/lid; other site 1126211009598 ABC transporter signature motif; other site 1126211009599 Walker B; other site 1126211009600 D-loop; other site 1126211009601 H-loop/switch region; other site 1126211009602 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 1126211009603 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1126211009604 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1126211009605 ABC-ATPase subunit interface; other site 1126211009606 dimer interface [polypeptide binding]; other site 1126211009607 putative PBP binding regions; other site 1126211009608 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1126211009609 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1126211009610 putative binding site residues; other site 1126211009611 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1126211009612 classical (c) SDRs; Region: SDR_c; cd05233 1126211009613 NAD(P) binding site [chemical binding]; other site 1126211009614 active site 1126211009615 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1126211009616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211009617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211009618 dimer interface [polypeptide binding]; other site 1126211009619 phosphorylation site [posttranslational modification] 1126211009620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211009621 ATP binding site [chemical binding]; other site 1126211009622 Mg2+ binding site [ion binding]; other site 1126211009623 G-X-G motif; other site 1126211009624 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211009625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211009626 active site 1126211009627 phosphorylation site [posttranslational modification] 1126211009628 intermolecular recognition site; other site 1126211009629 dimerization interface [polypeptide binding]; other site 1126211009630 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211009631 DNA binding site [nucleotide binding] 1126211009632 hypothetical protein; Provisional; Region: PRK14082 1126211009633 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1126211009634 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1126211009635 DNA binding residues [nucleotide binding] 1126211009636 YvrJ protein family; Region: YvrJ; pfam12841 1126211009637 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1126211009638 Cupin; Region: Cupin_1; smart00835 1126211009639 Cupin; Region: Cupin_1; smart00835 1126211009640 Regulatory protein YrvL; Region: YrvL; pfam14184 1126211009641 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1126211009642 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1126211009643 Walker A/P-loop; other site 1126211009644 ATP binding site [chemical binding]; other site 1126211009645 Q-loop/lid; other site 1126211009646 ABC transporter signature motif; other site 1126211009647 Walker B; other site 1126211009648 D-loop; other site 1126211009649 H-loop/switch region; other site 1126211009650 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1126211009651 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1126211009652 ABC-ATPase subunit interface; other site 1126211009653 dimer interface [polypeptide binding]; other site 1126211009654 putative PBP binding regions; other site 1126211009655 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1126211009656 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1126211009657 ABC-ATPase subunit interface; other site 1126211009658 dimer interface [polypeptide binding]; other site 1126211009659 putative PBP binding regions; other site 1126211009660 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1126211009661 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1126211009662 putative ligand binding residues [chemical binding]; other site 1126211009663 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1126211009664 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1126211009665 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 1126211009666 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; pfam09575 1126211009667 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1126211009668 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1126211009669 Sulfatase; Region: Sulfatase; pfam00884 1126211009670 DNA binding domain, excisionase family; Region: excise; TIGR01764 1126211009671 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 1126211009672 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1126211009673 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1126211009674 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1126211009675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211009676 dimer interface [polypeptide binding]; other site 1126211009677 conserved gate region; other site 1126211009678 putative PBP binding loops; other site 1126211009679 ABC-ATPase subunit interface; other site 1126211009680 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1126211009681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211009682 active site 1126211009683 phosphorylation site [posttranslational modification] 1126211009684 intermolecular recognition site; other site 1126211009685 dimerization interface [polypeptide binding]; other site 1126211009686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1126211009687 DNA binding residues [nucleotide binding] 1126211009688 dimerization interface [polypeptide binding]; other site 1126211009689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1126211009690 Histidine kinase; Region: HisKA_3; pfam07730 1126211009691 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1126211009692 Mg2+ binding site [ion binding]; other site 1126211009693 G-X-G motif; other site 1126211009694 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1126211009695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211009696 Walker A/P-loop; other site 1126211009697 ATP binding site [chemical binding]; other site 1126211009698 Q-loop/lid; other site 1126211009699 ABC transporter signature motif; other site 1126211009700 Walker B; other site 1126211009701 D-loop; other site 1126211009702 H-loop/switch region; other site 1126211009703 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1126211009704 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1126211009705 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1126211009706 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1126211009707 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1126211009708 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1126211009709 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1126211009710 active site 1126211009711 catalytic tetrad [active] 1126211009712 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1126211009713 sulfite reductase subunit beta; Provisional; Region: PRK13504 1126211009714 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1126211009715 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1126211009716 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1126211009717 Flavodoxin; Region: Flavodoxin_1; pfam00258 1126211009718 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1126211009719 FAD binding pocket [chemical binding]; other site 1126211009720 FAD binding motif [chemical binding]; other site 1126211009721 catalytic residues [active] 1126211009722 NAD binding pocket [chemical binding]; other site 1126211009723 phosphate binding motif [ion binding]; other site 1126211009724 beta-alpha-beta structure motif; other site 1126211009725 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1126211009726 Family description; Region: UvrD_C_2; pfam13538 1126211009727 Predicted membrane protein [Function unknown]; Region: COG2860 1126211009728 UPF0126 domain; Region: UPF0126; pfam03458 1126211009729 UPF0126 domain; Region: UPF0126; pfam03458 1126211009730 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 1126211009731 active site 1126211009732 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1126211009733 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1126211009734 Thioredoxin; Region: Thioredoxin_4; pfam13462 1126211009735 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1126211009736 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1126211009737 metal-binding site [ion binding] 1126211009738 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1126211009739 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1126211009740 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1126211009741 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1126211009742 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1126211009743 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1126211009744 metal-binding site [ion binding] 1126211009745 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1126211009746 putative homodimer interface [polypeptide binding]; other site 1126211009747 putative homotetramer interface [polypeptide binding]; other site 1126211009748 putative allosteric switch controlling residues; other site 1126211009749 putative metal binding site [ion binding]; other site 1126211009750 putative homodimer-homodimer interface [polypeptide binding]; other site 1126211009751 putative oxidoreductase; Provisional; Region: PRK11579 1126211009752 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1126211009753 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1126211009754 azoreductase; Reviewed; Region: PRK00170 1126211009755 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1126211009756 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1126211009757 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1126211009758 active site 1126211009759 non-prolyl cis peptide bond; other site 1126211009760 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1126211009761 catalytic residues [active] 1126211009762 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1126211009763 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1126211009764 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1126211009765 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1126211009766 Walker A/P-loop; other site 1126211009767 ATP binding site [chemical binding]; other site 1126211009768 Q-loop/lid; other site 1126211009769 ABC transporter signature motif; other site 1126211009770 Walker B; other site 1126211009771 D-loop; other site 1126211009772 H-loop/switch region; other site 1126211009773 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1126211009774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211009775 dimer interface [polypeptide binding]; other site 1126211009776 conserved gate region; other site 1126211009777 putative PBP binding loops; other site 1126211009778 ABC-ATPase subunit interface; other site 1126211009779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211009780 dimer interface [polypeptide binding]; other site 1126211009781 conserved gate region; other site 1126211009782 putative PBP binding loops; other site 1126211009783 ABC-ATPase subunit interface; other site 1126211009784 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1126211009785 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1126211009786 substrate binding pocket [chemical binding]; other site 1126211009787 membrane-bound complex binding site; other site 1126211009788 hinge residues; other site 1126211009789 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1126211009790 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1126211009791 substrate binding pocket [chemical binding]; other site 1126211009792 membrane-bound complex binding site; other site 1126211009793 hinge residues; other site 1126211009794 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1126211009795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211009796 Coenzyme A binding pocket [chemical binding]; other site 1126211009797 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1126211009798 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1126211009799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1126211009800 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1126211009801 dimerization interface [polypeptide binding]; other site 1126211009802 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1126211009803 classical (c) SDRs; Region: SDR_c; cd05233 1126211009804 NAD(P) binding site [chemical binding]; other site 1126211009805 active site 1126211009806 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1126211009807 SmpB-tmRNA interface; other site 1126211009808 ribonuclease R; Region: RNase_R; TIGR02063 1126211009809 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1126211009810 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1126211009811 RNB domain; Region: RNB; pfam00773 1126211009812 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1126211009813 RNA binding site [nucleotide binding]; other site 1126211009814 Esterase/lipase [General function prediction only]; Region: COG1647 1126211009815 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1126211009816 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1126211009817 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211009818 salt bridge; other site 1126211009819 non-specific DNA binding site [nucleotide binding]; other site 1126211009820 sequence-specific DNA binding site [nucleotide binding]; other site 1126211009821 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1126211009822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211009823 non-specific DNA binding site [nucleotide binding]; other site 1126211009824 salt bridge; other site 1126211009825 sequence-specific DNA binding site [nucleotide binding]; other site 1126211009826 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1126211009827 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211009828 non-specific DNA binding site [nucleotide binding]; other site 1126211009829 salt bridge; other site 1126211009830 sequence-specific DNA binding site [nucleotide binding]; other site 1126211009831 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1126211009832 Predicted transcriptional regulators [Transcription]; Region: COG1733 1126211009833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211009834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211009835 dimer interface [polypeptide binding]; other site 1126211009836 phosphorylation site [posttranslational modification] 1126211009837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211009838 ATP binding site [chemical binding]; other site 1126211009839 Mg2+ binding site [ion binding]; other site 1126211009840 G-X-G motif; other site 1126211009841 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211009842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211009843 active site 1126211009844 phosphorylation site [posttranslational modification] 1126211009845 intermolecular recognition site; other site 1126211009846 dimerization interface [polypeptide binding]; other site 1126211009847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211009848 DNA binding site [nucleotide binding] 1126211009849 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1126211009850 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1126211009851 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1126211009852 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1126211009853 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1126211009854 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211009855 Walker A/P-loop; other site 1126211009856 ATP binding site [chemical binding]; other site 1126211009857 Q-loop/lid; other site 1126211009858 ABC transporter signature motif; other site 1126211009859 Walker B; other site 1126211009860 D-loop; other site 1126211009861 H-loop/switch region; other site 1126211009862 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1126211009863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211009864 dimer interface [polypeptide binding]; other site 1126211009865 conserved gate region; other site 1126211009866 putative PBP binding loops; other site 1126211009867 ABC-ATPase subunit interface; other site 1126211009868 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1126211009869 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1126211009870 Walker A/P-loop; other site 1126211009871 ATP binding site [chemical binding]; other site 1126211009872 Q-loop/lid; other site 1126211009873 ABC transporter signature motif; other site 1126211009874 Walker B; other site 1126211009875 D-loop; other site 1126211009876 H-loop/switch region; other site 1126211009877 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1126211009878 Predicted transcriptional regulators [Transcription]; Region: COG1510 1126211009879 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1126211009880 putative DNA binding site [nucleotide binding]; other site 1126211009881 putative Zn2+ binding site [ion binding]; other site 1126211009882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211009883 dimer interface [polypeptide binding]; other site 1126211009884 conserved gate region; other site 1126211009885 putative PBP binding loops; other site 1126211009886 ABC-ATPase subunit interface; other site 1126211009887 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1126211009888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211009889 dimer interface [polypeptide binding]; other site 1126211009890 conserved gate region; other site 1126211009891 putative PBP binding loops; other site 1126211009892 ABC-ATPase subunit interface; other site 1126211009893 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1126211009894 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1126211009895 Walker A/P-loop; other site 1126211009896 ATP binding site [chemical binding]; other site 1126211009897 Q-loop/lid; other site 1126211009898 ABC transporter signature motif; other site 1126211009899 Walker B; other site 1126211009900 D-loop; other site 1126211009901 H-loop/switch region; other site 1126211009902 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1126211009903 Predicted transcriptional regulators [Transcription]; Region: COG1510 1126211009904 MarR family; Region: MarR_2; pfam12802 1126211009905 membrane protein, MarC family; Region: TIGR00427 1126211009906 Predicted membrane protein [Function unknown]; Region: COG4640 1126211009907 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1126211009908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211009909 Coenzyme A binding pocket [chemical binding]; other site 1126211009910 enolase; Provisional; Region: eno; PRK00077 1126211009911 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1126211009912 dimer interface [polypeptide binding]; other site 1126211009913 metal binding site [ion binding]; metal-binding site 1126211009914 substrate binding pocket [chemical binding]; other site 1126211009915 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1126211009916 phosphoglyceromutase; Provisional; Region: PRK05434 1126211009917 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1126211009918 triosephosphate isomerase; Provisional; Region: PRK14565 1126211009919 substrate binding site [chemical binding]; other site 1126211009920 dimer interface [polypeptide binding]; other site 1126211009921 catalytic triad [active] 1126211009922 Phosphoglycerate kinase; Region: PGK; pfam00162 1126211009923 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1126211009924 substrate binding site [chemical binding]; other site 1126211009925 hinge regions; other site 1126211009926 ADP binding site [chemical binding]; other site 1126211009927 catalytic site [active] 1126211009928 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1126211009929 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1126211009930 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1126211009931 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1126211009932 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1126211009933 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1126211009934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211009935 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211009936 DNA-binding site [nucleotide binding]; DNA binding site 1126211009937 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1126211009938 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1126211009939 putative dimerization interface [polypeptide binding]; other site 1126211009940 putative ligand binding site [chemical binding]; other site 1126211009941 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1126211009942 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1126211009943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1126211009944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1126211009945 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1126211009946 dimerization interface [polypeptide binding]; other site 1126211009947 EamA-like transporter family; Region: EamA; pfam00892 1126211009948 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1126211009949 EamA-like transporter family; Region: EamA; pfam00892 1126211009950 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1126211009951 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1126211009952 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1126211009953 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1126211009954 putative active site [active] 1126211009955 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1126211009956 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1126211009957 N- and C-terminal domain interface [polypeptide binding]; other site 1126211009958 active site 1126211009959 catalytic site [active] 1126211009960 metal binding site [ion binding]; metal-binding site 1126211009961 carbohydrate binding site [chemical binding]; other site 1126211009962 ATP binding site [chemical binding]; other site 1126211009963 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1126211009964 GntP family permease; Region: GntP_permease; pfam02447 1126211009965 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1126211009966 iron-sulfur cluster-binding protein; Region: TIGR00273 1126211009967 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1126211009968 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1126211009969 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1126211009970 Cysteine-rich domain; Region: CCG; pfam02754 1126211009971 Cysteine-rich domain; Region: CCG; pfam02754 1126211009972 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1126211009973 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211009974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211009975 homodimer interface [polypeptide binding]; other site 1126211009976 catalytic residue [active] 1126211009977 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1126211009978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211009979 DNA-binding site [nucleotide binding]; DNA binding site 1126211009980 FCD domain; Region: FCD; pfam07729 1126211009981 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1126211009982 L-lactate permease; Region: Lactate_perm; pfam02652 1126211009983 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1126211009984 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1126211009985 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1126211009986 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1126211009987 YvfG protein; Region: YvfG; pfam09628 1126211009988 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1126211009989 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1126211009990 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1126211009991 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1126211009992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211009993 inhibitor-cofactor binding pocket; inhibition site 1126211009994 catalytic residue [active] 1126211009995 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1126211009996 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1126211009997 putative trimer interface [polypeptide binding]; other site 1126211009998 putative CoA binding site [chemical binding]; other site 1126211009999 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1126211010000 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1126211010001 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1126211010002 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1126211010003 active site 1126211010004 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1126211010005 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1126211010006 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1126211010007 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1126211010008 active site 1126211010009 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1126211010010 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1126211010011 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1126211010012 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1126211010013 active site 1126211010014 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1126211010015 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1126211010016 putative ADP-binding pocket [chemical binding]; other site 1126211010017 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1126211010018 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1126211010019 NAD(P) binding site [chemical binding]; other site 1126211010020 homodimer interface [polypeptide binding]; other site 1126211010021 substrate binding site [chemical binding]; other site 1126211010022 active site 1126211010023 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1126211010024 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1126211010025 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1126211010026 Chain length determinant protein; Region: Wzz; cl15801 1126211010027 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1126211010028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211010029 non-specific DNA binding site [nucleotide binding]; other site 1126211010030 salt bridge; other site 1126211010031 sequence-specific DNA binding site [nucleotide binding]; other site 1126211010032 Anti-repressor SinI; Region: SinI; pfam08671 1126211010033 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1126211010034 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1126211010035 substrate binding pocket [chemical binding]; other site 1126211010036 catalytic triad [active] 1126211010037 RibD C-terminal domain; Region: RibD_C; cl17279 1126211010038 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1126211010039 Predicted membrane protein [Function unknown]; Region: COG2364 1126211010040 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1126211010041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211010042 Coenzyme A binding pocket [chemical binding]; other site 1126211010043 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1126211010044 hypothetical protein; Provisional; Region: PRK00872 1126211010045 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1126211010046 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1126211010047 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1126211010048 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1126211010049 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1126211010050 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1126211010051 substrate binding [chemical binding]; other site 1126211010052 active site 1126211010053 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1126211010054 galactoside permease; Reviewed; Region: lacY; PRK09528 1126211010055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211010056 putative substrate translocation pore; other site 1126211010057 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1126211010058 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1126211010059 DNA binding site [nucleotide binding] 1126211010060 domain linker motif; other site 1126211010061 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1126211010062 dimerization interface [polypeptide binding]; other site 1126211010063 ligand binding site [chemical binding]; other site 1126211010064 sodium binding site [ion binding]; other site 1126211010065 Clp protease; Region: CLP_protease; pfam00574 1126211010066 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1126211010067 oligomer interface [polypeptide binding]; other site 1126211010068 active site residues [active] 1126211010069 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1126211010070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211010071 motif II; other site 1126211010072 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1126211010073 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1126211010074 Ca binding site [ion binding]; other site 1126211010075 active site 1126211010076 catalytic site [active] 1126211010077 maltose phosphorylase; Provisional; Region: PRK13807 1126211010078 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1126211010079 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1126211010080 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1126211010081 Predicted integral membrane protein [Function unknown]; Region: COG5521 1126211010082 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1126211010083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211010084 dimer interface [polypeptide binding]; other site 1126211010085 conserved gate region; other site 1126211010086 ABC-ATPase subunit interface; other site 1126211010087 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1126211010088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1126211010089 dimer interface [polypeptide binding]; other site 1126211010090 conserved gate region; other site 1126211010091 putative PBP binding loops; other site 1126211010092 ABC-ATPase subunit interface; other site 1126211010093 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1126211010094 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1126211010095 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1126211010096 homodimer interface [polypeptide binding]; other site 1126211010097 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1126211010098 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1126211010099 active site 1126211010100 homodimer interface [polypeptide binding]; other site 1126211010101 catalytic site [active] 1126211010102 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1126211010103 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1126211010104 DNA binding site [nucleotide binding] 1126211010105 domain linker motif; other site 1126211010106 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1126211010107 ligand binding site [chemical binding]; other site 1126211010108 dimerization interface [polypeptide binding]; other site 1126211010109 TIGR00730 family protein; Region: TIGR00730 1126211010110 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1126211010111 metal binding site [ion binding]; metal-binding site 1126211010112 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1126211010113 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1126211010114 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1126211010115 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1126211010116 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1126211010117 active site clefts [active] 1126211010118 zinc binding site [ion binding]; other site 1126211010119 dimer interface [polypeptide binding]; other site 1126211010120 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1126211010121 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1126211010122 dimerization interface [polypeptide binding]; other site 1126211010123 ligand binding site [chemical binding]; other site 1126211010124 NADP binding site [chemical binding]; other site 1126211010125 catalytic site [active] 1126211010126 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 1126211010127 active site 1126211010128 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1126211010129 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1126211010130 dimerization domain swap beta strand [polypeptide binding]; other site 1126211010131 regulatory protein interface [polypeptide binding]; other site 1126211010132 active site 1126211010133 regulatory phosphorylation site [posttranslational modification]; other site 1126211010134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1126211010135 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1126211010136 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1126211010137 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1126211010138 phosphate binding site [ion binding]; other site 1126211010139 putative substrate binding pocket [chemical binding]; other site 1126211010140 dimer interface [polypeptide binding]; other site 1126211010141 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1126211010142 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1126211010143 putative active site [active] 1126211010144 nucleotide binding site [chemical binding]; other site 1126211010145 nudix motif; other site 1126211010146 putative metal binding site [ion binding]; other site 1126211010147 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1126211010148 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1126211010149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1126211010150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1126211010151 GDP/GTP exchange factor Sec2p; Region: Sec2p; pfam06428 1126211010152 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1126211010153 NlpC/P60 family; Region: NLPC_P60; pfam00877 1126211010154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211010155 binding surface 1126211010156 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1126211010157 TPR motif; other site 1126211010158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211010159 TPR motif; other site 1126211010160 binding surface 1126211010161 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211010162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211010163 dimer interface [polypeptide binding]; other site 1126211010164 phosphorylation site [posttranslational modification] 1126211010165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211010166 ATP binding site [chemical binding]; other site 1126211010167 Mg2+ binding site [ion binding]; other site 1126211010168 G-X-G motif; other site 1126211010169 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211010170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211010171 active site 1126211010172 phosphorylation site [posttranslational modification] 1126211010173 intermolecular recognition site; other site 1126211010174 dimerization interface [polypeptide binding]; other site 1126211010175 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211010176 DNA binding site [nucleotide binding] 1126211010177 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1126211010178 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1126211010179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211010180 Walker A/P-loop; other site 1126211010181 ATP binding site [chemical binding]; other site 1126211010182 Q-loop/lid; other site 1126211010183 ABC transporter signature motif; other site 1126211010184 Walker B; other site 1126211010185 D-loop; other site 1126211010186 H-loop/switch region; other site 1126211010187 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1126211010188 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1126211010189 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1126211010190 metal binding site [ion binding]; metal-binding site 1126211010191 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1126211010192 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1126211010193 substrate binding site [chemical binding]; other site 1126211010194 glutamase interaction surface [polypeptide binding]; other site 1126211010195 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1126211010196 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1126211010197 catalytic residues [active] 1126211010198 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1126211010199 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1126211010200 putative active site [active] 1126211010201 oxyanion strand; other site 1126211010202 catalytic triad [active] 1126211010203 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1126211010204 putative active site pocket [active] 1126211010205 4-fold oligomerization interface [polypeptide binding]; other site 1126211010206 metal binding residues [ion binding]; metal-binding site 1126211010207 3-fold/trimer interface [polypeptide binding]; other site 1126211010208 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1126211010209 histidinol dehydrogenase; Region: hisD; TIGR00069 1126211010210 NAD binding site [chemical binding]; other site 1126211010211 dimerization interface [polypeptide binding]; other site 1126211010212 product binding site; other site 1126211010213 substrate binding site [chemical binding]; other site 1126211010214 zinc binding site [ion binding]; other site 1126211010215 catalytic residues [active] 1126211010216 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1126211010217 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1126211010218 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1126211010219 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1126211010220 dimer interface [polypeptide binding]; other site 1126211010221 motif 1; other site 1126211010222 active site 1126211010223 motif 2; other site 1126211010224 motif 3; other site 1126211010225 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1126211010226 putative active site [active] 1126211010227 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1126211010228 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1126211010229 trimer interface [polypeptide binding]; other site 1126211010230 active site 1126211010231 substrate binding site [chemical binding]; other site 1126211010232 CoA binding site [chemical binding]; other site 1126211010233 pyrophosphatase PpaX; Provisional; Region: PRK13288 1126211010234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1126211010235 motif I; other site 1126211010236 active site 1126211010237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211010238 motif II; other site 1126211010239 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1126211010240 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1126211010241 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1126211010242 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1126211010243 Hpr binding site; other site 1126211010244 active site 1126211010245 homohexamer subunit interaction site [polypeptide binding]; other site 1126211010246 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1126211010247 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1126211010248 active site 1126211010249 dimer interface [polypeptide binding]; other site 1126211010250 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1126211010251 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1126211010252 active site 1126211010253 trimer interface [polypeptide binding]; other site 1126211010254 allosteric site; other site 1126211010255 active site lid [active] 1126211010256 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1126211010257 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1126211010258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211010259 DNA-binding site [nucleotide binding]; DNA binding site 1126211010260 UTRA domain; Region: UTRA; pfam07702 1126211010261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211010262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211010263 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1126211010264 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1126211010265 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1126211010266 putative active site [active] 1126211010267 putative metal binding site [ion binding]; other site 1126211010268 Predicted membrane protein [Function unknown]; Region: COG1950 1126211010269 PspC domain; Region: PspC; pfam04024 1126211010270 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1126211010271 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1126211010272 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1126211010273 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1126211010274 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1126211010275 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1126211010276 excinuclease ABC subunit B; Provisional; Region: PRK05298 1126211010277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1126211010278 ATP binding site [chemical binding]; other site 1126211010279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211010280 nucleotide binding region [chemical binding]; other site 1126211010281 ATP-binding site [chemical binding]; other site 1126211010282 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1126211010283 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 1126211010284 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1126211010285 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1126211010286 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1126211010287 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211010288 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211010289 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1126211010290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211010291 putative substrate translocation pore; other site 1126211010292 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1126211010293 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 1126211010294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1126211010295 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1126211010296 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1126211010297 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1126211010298 Walker A/P-loop; other site 1126211010299 ATP binding site [chemical binding]; other site 1126211010300 Q-loop/lid; other site 1126211010301 ABC transporter signature motif; other site 1126211010302 Walker B; other site 1126211010303 D-loop; other site 1126211010304 H-loop/switch region; other site 1126211010305 Condensation domain; Region: Condensation; pfam00668 1126211010306 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1126211010307 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211010308 Condensation domain; Region: Condensation; pfam00668 1126211010309 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211010310 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211010311 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211010312 acyl-activating enzyme (AAE) consensus motif; other site 1126211010313 AMP binding site [chemical binding]; other site 1126211010314 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211010315 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211010316 Condensation domain; Region: Condensation; pfam00668 1126211010317 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1126211010318 Condensation domain; Region: Condensation; pfam00668 1126211010319 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211010320 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1126211010321 acyl-activating enzyme (AAE) consensus motif; other site 1126211010322 AMP binding site [chemical binding]; other site 1126211010323 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1126211010324 Condensation domain; Region: Condensation; pfam00668 1126211010325 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211010326 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1126211010327 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1126211010328 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1126211010329 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1126211010330 acyl-activating enzyme (AAE) consensus motif; other site 1126211010331 AMP binding site [chemical binding]; other site 1126211010332 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 1126211010333 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1126211010334 NADP binding site [chemical binding]; other site 1126211010335 homodimer interface [polypeptide binding]; other site 1126211010336 active site 1126211010337 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1126211010338 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1126211010339 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1126211010340 C-terminal peptidase (prc); Region: prc; TIGR00225 1126211010341 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1126211010342 protein binding site [polypeptide binding]; other site 1126211010343 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1126211010344 Catalytic dyad [active] 1126211010345 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1126211010346 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1126211010347 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1126211010348 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1126211010349 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1126211010350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211010351 Walker A/P-loop; other site 1126211010352 ATP binding site [chemical binding]; other site 1126211010353 Q-loop/lid; other site 1126211010354 ABC transporter signature motif; other site 1126211010355 Walker B; other site 1126211010356 D-loop; other site 1126211010357 H-loop/switch region; other site 1126211010358 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1126211010359 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1126211010360 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1126211010361 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1126211010362 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1126211010363 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1126211010364 peptide chain release factor 2; Provisional; Region: PRK06746 1126211010365 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1126211010366 RF-1 domain; Region: RF-1; pfam00472 1126211010367 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1126211010368 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1126211010369 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1126211010370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1126211010371 nucleotide binding region [chemical binding]; other site 1126211010372 ATP-binding site [chemical binding]; other site 1126211010373 SEC-C motif; Region: SEC-C; pfam02810 1126211010374 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1126211010375 30S subunit binding site; other site 1126211010376 Flagellar protein FliT; Region: FliT; pfam05400 1126211010377 flagellar protein FliS; Validated; Region: fliS; PRK05685 1126211010378 flagellar capping protein; Validated; Region: fliD; PRK07737 1126211010379 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1126211010380 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1126211010381 flagellin; Provisional; Region: PRK12804 1126211010382 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1126211010383 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1126211010384 carbon storage regulator; Provisional; Region: PRK01712 1126211010385 flagellar assembly protein FliW; Provisional; Region: PRK13285 1126211010386 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1126211010387 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1126211010388 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1126211010389 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1126211010390 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1126211010391 FlgN protein; Region: FlgN; pfam05130 1126211010392 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1126211010393 flagellar operon protein TIGR03826; Region: YvyF 1126211010394 comF family protein; Region: comF; TIGR00201 1126211010395 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1126211010396 active site 1126211010397 Late competence development protein ComFB; Region: ComFB; pfam10719 1126211010398 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1126211010399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1126211010400 ATP binding site [chemical binding]; other site 1126211010401 putative Mg++ binding site [ion binding]; other site 1126211010402 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211010403 nucleotide binding region [chemical binding]; other site 1126211010404 ATP-binding site [chemical binding]; other site 1126211010405 EDD domain protein, DegV family; Region: DegV; TIGR00762 1126211010406 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1126211010407 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1126211010408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211010409 active site 1126211010410 phosphorylation site [posttranslational modification] 1126211010411 intermolecular recognition site; other site 1126211010412 dimerization interface [polypeptide binding]; other site 1126211010413 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1126211010414 DNA binding residues [nucleotide binding] 1126211010415 dimerization interface [polypeptide binding]; other site 1126211010416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1126211010417 Histidine kinase; Region: HisKA_3; pfam07730 1126211010418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211010419 ATP binding site [chemical binding]; other site 1126211010420 Mg2+ binding site [ion binding]; other site 1126211010421 G-X-G motif; other site 1126211010422 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1126211010423 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1126211010424 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1126211010425 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1126211010426 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1126211010427 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1126211010428 Mg++ binding site [ion binding]; other site 1126211010429 putative catalytic motif [active] 1126211010430 substrate binding site [chemical binding]; other site 1126211010431 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1126211010432 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1126211010433 putative homodimer interface [polypeptide binding]; other site 1126211010434 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1126211010435 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1126211010436 active site 1126211010437 O-Antigen ligase; Region: Wzy_C; pfam04932 1126211010438 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1126211010439 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1126211010440 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1126211010441 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1126211010442 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1126211010443 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1126211010444 colanic acid exporter; Provisional; Region: PRK10459 1126211010445 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1126211010446 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1126211010447 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1126211010448 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1126211010449 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1126211010450 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1126211010451 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1126211010452 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1126211010453 active site 1126211010454 metal binding site [ion binding]; metal-binding site 1126211010455 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1126211010456 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1126211010457 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1126211010458 Stage II sporulation protein; Region: SpoIID; pfam08486 1126211010459 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1126211010460 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1126211010461 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1126211010462 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1126211010463 active site 1126211010464 homodimer interface [polypeptide binding]; other site 1126211010465 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1126211010466 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1126211010467 active site 1126211010468 tetramer interface; other site 1126211010469 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1126211010470 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1126211010471 Walker A/P-loop; other site 1126211010472 ATP binding site [chemical binding]; other site 1126211010473 Q-loop/lid; other site 1126211010474 ABC transporter signature motif; other site 1126211010475 Walker B; other site 1126211010476 D-loop; other site 1126211010477 H-loop/switch region; other site 1126211010478 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1126211010479 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1126211010480 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1126211010481 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1126211010482 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1126211010483 active site 1126211010484 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1126211010485 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1126211010486 active site 1126211010487 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1126211010488 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1126211010489 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1126211010490 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1126211010491 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1126211010492 Bacterial SH3 domain; Region: SH3_3; pfam08239 1126211010493 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1126211010494 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1126211010495 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1126211010496 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1126211010497 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1126211010498 Spore germination protein; Region: Spore_permease; pfam03845 1126211010499 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1126211010500 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1126211010501 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1126211010502 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1126211010503 Probable Catalytic site; other site 1126211010504 metal-binding site 1126211010505 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1126211010506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211010507 S-adenosylmethionine binding site [chemical binding]; other site 1126211010508 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1126211010509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211010510 putative substrate translocation pore; other site 1126211010511 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1126211010512 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211010513 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1126211010514 active site 1126211010515 motif I; other site 1126211010516 motif II; other site 1126211010517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211010518 Septum formation initiator; Region: DivIC; cl17659 1126211010519 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 1126211010520 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1126211010521 NlpC/P60 family; Region: NLPC_P60; pfam00877 1126211010522 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1126211010523 NlpC/P60 family; Region: NLPC_P60; pfam00877 1126211010524 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1126211010525 NlpC/P60 family; Region: NLPC_P60; pfam00877 1126211010526 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1126211010527 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1126211010528 putative active site [active] 1126211010529 putative metal binding site [ion binding]; other site 1126211010530 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 1126211010531 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1126211010532 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1126211010533 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1126211010534 Spore germination protein; Region: Spore_permease; cl17796 1126211010535 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1126211010536 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1126211010537 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1126211010538 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1126211010539 DNA binding site [nucleotide binding] 1126211010540 domain linker motif; other site 1126211010541 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1126211010542 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1126211010543 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1126211010544 substrate binding site [chemical binding]; other site 1126211010545 dimer interface [polypeptide binding]; other site 1126211010546 ATP binding site [chemical binding]; other site 1126211010547 D-ribose pyranase; Provisional; Region: PRK11797 1126211010548 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1126211010549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211010550 Walker A/P-loop; other site 1126211010551 ATP binding site [chemical binding]; other site 1126211010552 Q-loop/lid; other site 1126211010553 ABC transporter signature motif; other site 1126211010554 Walker B; other site 1126211010555 D-loop; other site 1126211010556 H-loop/switch region; other site 1126211010557 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1126211010558 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1126211010559 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1126211010560 TM-ABC transporter signature motif; other site 1126211010561 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1126211010562 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1126211010563 ligand binding site [chemical binding]; other site 1126211010564 dimerization interface [polypeptide binding]; other site 1126211010565 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1126211010566 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1126211010567 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1126211010568 acetolactate synthase; Reviewed; Region: PRK08617 1126211010569 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1126211010570 PYR/PP interface [polypeptide binding]; other site 1126211010571 dimer interface [polypeptide binding]; other site 1126211010572 TPP binding site [chemical binding]; other site 1126211010573 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1126211010574 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1126211010575 TPP-binding site [chemical binding]; other site 1126211010576 dimer interface [polypeptide binding]; other site 1126211010577 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1126211010578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1126211010579 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1126211010580 putative dimerization interface [polypeptide binding]; other site 1126211010581 putative substrate binding pocket [chemical binding]; other site 1126211010582 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1126211010583 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1126211010584 transmembrane helices; other site 1126211010585 CotH protein; Region: CotH; pfam08757 1126211010586 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1126211010587 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1126211010588 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1126211010589 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1126211010590 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1126211010591 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1126211010592 putative DNA binding site [nucleotide binding]; other site 1126211010593 putative Zn2+ binding site [ion binding]; other site 1126211010594 AsnC family; Region: AsnC_trans_reg; pfam01037 1126211010595 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1126211010596 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1126211010597 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1126211010598 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1126211010599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1126211010600 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1126211010601 dimerization interface [polypeptide binding]; other site 1126211010602 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1126211010603 Active_site [active] 1126211010604 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1126211010605 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 1126211010606 LXG domain of WXG superfamily; Region: LXG; pfam04740 1126211010607 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1126211010608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1126211010609 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1126211010610 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1126211010611 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1126211010612 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1126211010613 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1126211010614 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1126211010615 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1126211010616 Nucleotide binding site [chemical binding]; other site 1126211010617 DTAP/Switch II; other site 1126211010618 Switch I; other site 1126211010619 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1126211010620 Chain length determinant protein; Region: Wzz; cl15801 1126211010621 SWIM zinc finger; Region: SWIM; pfam04434 1126211010622 SNF2 Helicase protein; Region: DUF3670; pfam12419 1126211010623 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1126211010624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1126211010625 ATP binding site [chemical binding]; other site 1126211010626 putative Mg++ binding site [ion binding]; other site 1126211010627 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1126211010628 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211010629 nucleotide binding region [chemical binding]; other site 1126211010630 ATP-binding site [chemical binding]; other site 1126211010631 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211010632 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1126211010633 active site 1126211010634 motif I; other site 1126211010635 motif II; other site 1126211010636 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211010637 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1126211010638 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1126211010639 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1126211010640 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1126211010641 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1126211010642 dimer interface [polypeptide binding]; other site 1126211010643 ssDNA binding site [nucleotide binding]; other site 1126211010644 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1126211010645 YwpF-like protein; Region: YwpF; pfam14183 1126211010646 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1126211010647 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1126211010648 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1126211010649 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211010650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211010651 binding surface 1126211010652 TPR motif; other site 1126211010653 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211010654 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1126211010655 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1126211010656 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1126211010657 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1126211010658 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1126211010659 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1126211010660 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1126211010661 MreB and similar proteins; Region: MreB_like; cd10225 1126211010662 nucleotide binding site [chemical binding]; other site 1126211010663 Mg binding site [ion binding]; other site 1126211010664 putative protofilament interaction site [polypeptide binding]; other site 1126211010665 RodZ interaction site [polypeptide binding]; other site 1126211010666 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1126211010667 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211010668 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1126211010669 putative Zn2+ binding site [ion binding]; other site 1126211010670 putative DNA binding site [nucleotide binding]; other site 1126211010671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211010672 putative substrate translocation pore; other site 1126211010673 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211010674 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1126211010675 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1126211010676 Na binding site [ion binding]; other site 1126211010677 putative substrate binding site [chemical binding]; other site 1126211010678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211010679 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211010680 putative substrate translocation pore; other site 1126211010681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211010682 Isochorismatase family; Region: Isochorismatase; pfam00857 1126211010683 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1126211010684 catalytic triad [active] 1126211010685 conserved cis-peptide bond; other site 1126211010686 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1126211010687 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1126211010688 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1126211010689 cell division protein FtsW; Region: ftsW; TIGR02614 1126211010690 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1126211010691 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1126211010692 active site 1126211010693 VanZ like family; Region: VanZ; pfam04892 1126211010694 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1126211010695 Peptidase family M23; Region: Peptidase_M23; pfam01551 1126211010696 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1126211010697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211010698 Coenzyme A binding pocket [chemical binding]; other site 1126211010699 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1126211010700 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1126211010701 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1126211010702 putative active site [active] 1126211010703 catalytic site [active] 1126211010704 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1126211010705 putative active site [active] 1126211010706 catalytic site [active] 1126211010707 Predicted transcriptional regulator [Transcription]; Region: COG1959 1126211010708 Transcriptional regulator; Region: Rrf2; pfam02082 1126211010709 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1126211010710 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1126211010711 subunit interactions [polypeptide binding]; other site 1126211010712 active site 1126211010713 flap region; other site 1126211010714 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1126211010715 gamma-beta subunit interface [polypeptide binding]; other site 1126211010716 alpha-beta subunit interface [polypeptide binding]; other site 1126211010717 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1126211010718 alpha-gamma subunit interface [polypeptide binding]; other site 1126211010719 beta-gamma subunit interface [polypeptide binding]; other site 1126211010720 CsbD-like; Region: CsbD; pfam05532 1126211010721 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211010722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211010723 binding surface 1126211010724 TPR motif; other site 1126211010725 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1126211010726 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1126211010727 FeS/SAM binding site; other site 1126211010728 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1126211010729 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1126211010730 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1126211010731 metal ion-dependent adhesion site (MIDAS); other site 1126211010732 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1126211010733 metal ion-dependent adhesion site (MIDAS); other site 1126211010734 Stage II sporulation protein; Region: SpoIID; pfam08486 1126211010735 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1126211010736 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1126211010737 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1126211010738 hinge; other site 1126211010739 active site 1126211010740 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1126211010741 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1126211010742 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1126211010743 gamma subunit interface [polypeptide binding]; other site 1126211010744 epsilon subunit interface [polypeptide binding]; other site 1126211010745 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1126211010746 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1126211010747 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1126211010748 alpha subunit interaction interface [polypeptide binding]; other site 1126211010749 Walker A motif; other site 1126211010750 ATP binding site [chemical binding]; other site 1126211010751 Walker B motif; other site 1126211010752 inhibitor binding site; inhibition site 1126211010753 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1126211010754 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1126211010755 core domain interface [polypeptide binding]; other site 1126211010756 delta subunit interface [polypeptide binding]; other site 1126211010757 epsilon subunit interface [polypeptide binding]; other site 1126211010758 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1126211010759 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1126211010760 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1126211010761 beta subunit interaction interface [polypeptide binding]; other site 1126211010762 Walker A motif; other site 1126211010763 ATP binding site [chemical binding]; other site 1126211010764 Walker B motif; other site 1126211010765 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1126211010766 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 1126211010767 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1126211010768 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1126211010769 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1126211010770 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1126211010771 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1126211010772 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1126211010773 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1126211010774 active site 1126211010775 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1126211010776 hypothetical protein; Provisional; Region: PRK13690 1126211010777 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1126211010778 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1126211010779 Predicted membrane protein [Function unknown]; Region: COG1971 1126211010780 Domain of unknown function DUF; Region: DUF204; pfam02659 1126211010781 Domain of unknown function DUF; Region: DUF204; pfam02659 1126211010782 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1126211010783 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1126211010784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1126211010785 stage II sporulation protein R; Region: spore_II_R; TIGR02837 1126211010786 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1126211010787 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1126211010788 RF-1 domain; Region: RF-1; pfam00472 1126211010789 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1126211010790 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1126211010791 putative metal binding site [ion binding]; other site 1126211010792 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1126211010793 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1126211010794 DNA binding residues [nucleotide binding] 1126211010795 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1126211010796 malate dehydrogenase; Provisional; Region: PRK13529 1126211010797 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1126211010798 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1126211010799 NAD(P) binding site [chemical binding]; other site 1126211010800 thymidine kinase; Provisional; Region: PRK04296 1126211010801 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1126211010802 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1126211010803 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1126211010804 RNA binding site [nucleotide binding]; other site 1126211010805 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1126211010806 multimer interface [polypeptide binding]; other site 1126211010807 Walker A motif; other site 1126211010808 ATP binding site [chemical binding]; other site 1126211010809 Walker B motif; other site 1126211010810 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1126211010811 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1126211010812 putative active site [active] 1126211010813 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1126211010814 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1126211010815 hinge; other site 1126211010816 active site 1126211010817 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1126211010818 active site 1126211010819 intersubunit interactions; other site 1126211010820 catalytic residue [active] 1126211010821 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1126211010822 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1126211010823 intersubunit interface [polypeptide binding]; other site 1126211010824 active site 1126211010825 zinc binding site [ion binding]; other site 1126211010826 Na+ binding site [ion binding]; other site 1126211010827 Response regulator receiver domain; Region: Response_reg; pfam00072 1126211010828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211010829 active site 1126211010830 phosphorylation site [posttranslational modification] 1126211010831 intermolecular recognition site; other site 1126211010832 dimerization interface [polypeptide binding]; other site 1126211010833 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1126211010834 CTP synthetase; Validated; Region: pyrG; PRK05380 1126211010835 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1126211010836 Catalytic site [active] 1126211010837 active site 1126211010838 UTP binding site [chemical binding]; other site 1126211010839 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1126211010840 active site 1126211010841 putative oxyanion hole; other site 1126211010842 catalytic triad [active] 1126211010843 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1126211010844 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1126211010845 Cysteine-rich domain; Region: CCG; pfam02754 1126211010846 Cysteine-rich domain; Region: CCG; pfam02754 1126211010847 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1126211010848 PLD-like domain; Region: PLDc_2; pfam13091 1126211010849 putative active site [active] 1126211010850 catalytic site [active] 1126211010851 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1126211010852 PLD-like domain; Region: PLDc_2; pfam13091 1126211010853 putative active site [active] 1126211010854 catalytic site [active] 1126211010855 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 1126211010856 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1126211010857 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1126211010858 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1126211010859 Walker A/P-loop; other site 1126211010860 ATP binding site [chemical binding]; other site 1126211010861 Q-loop/lid; other site 1126211010862 ABC transporter signature motif; other site 1126211010863 Walker B; other site 1126211010864 D-loop; other site 1126211010865 H-loop/switch region; other site 1126211010866 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1126211010867 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1126211010868 putative active site [active] 1126211010869 catalytic site [active] 1126211010870 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1126211010871 putative active site [active] 1126211010872 catalytic site [active] 1126211010873 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1126211010874 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1126211010875 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1126211010876 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1126211010877 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1126211010878 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1126211010879 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1126211010880 [4Fe-4S] binding site [ion binding]; other site 1126211010881 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1126211010882 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1126211010883 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1126211010884 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1126211010885 molybdopterin cofactor binding site; other site 1126211010886 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1126211010887 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1126211010888 ligand binding site [chemical binding]; other site 1126211010889 flexible hinge region; other site 1126211010890 YwiC-like protein; Region: YwiC; pfam14256 1126211010891 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1126211010892 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1126211010893 ligand binding site [chemical binding]; other site 1126211010894 flexible hinge region; other site 1126211010895 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1126211010896 putative switch regulator; other site 1126211010897 non-specific DNA interactions [nucleotide binding]; other site 1126211010898 DNA binding site [nucleotide binding] 1126211010899 sequence specific DNA binding site [nucleotide binding]; other site 1126211010900 putative cAMP binding site [chemical binding]; other site 1126211010901 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1126211010902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211010903 putative substrate translocation pore; other site 1126211010904 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1126211010905 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1126211010906 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1126211010907 active site 1126211010908 HIGH motif; other site 1126211010909 KMSK motif region; other site 1126211010910 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1126211010911 tRNA binding surface [nucleotide binding]; other site 1126211010912 anticodon binding site; other site 1126211010913 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1126211010914 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211010915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1126211010916 binding surface 1126211010917 TPR motif; other site 1126211010918 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211010919 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1126211010920 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1126211010921 non-specific DNA binding site [nucleotide binding]; other site 1126211010922 salt bridge; other site 1126211010923 sequence-specific DNA binding site [nucleotide binding]; other site 1126211010924 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1126211010925 Integral membrane protein DUF95; Region: DUF95; pfam01944 1126211010926 agmatinase; Region: agmatinase; TIGR01230 1126211010927 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1126211010928 putative active site [active] 1126211010929 Mn binding site [ion binding]; other site 1126211010930 spermidine synthase; Provisional; Region: PRK00811 1126211010931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1126211010932 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1126211010933 Transglycosylase; Region: Transgly; pfam00912 1126211010934 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1126211010935 YwhD family; Region: YwhD; pfam08741 1126211010936 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1126211010937 Peptidase family M50; Region: Peptidase_M50; pfam02163 1126211010938 active site 1126211010939 putative substrate binding region [chemical binding]; other site 1126211010940 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1126211010941 active site 1 [active] 1126211010942 dimer interface [polypeptide binding]; other site 1126211010943 hexamer interface [polypeptide binding]; other site 1126211010944 active site 2 [active] 1126211010945 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1126211010946 dimerization interface [polypeptide binding]; other site 1126211010947 putative DNA binding site [nucleotide binding]; other site 1126211010948 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211010949 putative Zn2+ binding site [ion binding]; other site 1126211010950 amino acid transporter; Region: 2A0306; TIGR00909 1126211010951 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1126211010952 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1126211010953 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1126211010954 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1126211010955 Zn2+ binding site [ion binding]; other site 1126211010956 Mg2+ binding site [ion binding]; other site 1126211010957 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1126211010958 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1126211010959 Predicted transcriptional regulators [Transcription]; Region: COG1695 1126211010960 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1126211010961 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1126211010962 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1126211010963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211010964 Walker A/P-loop; other site 1126211010965 ATP binding site [chemical binding]; other site 1126211010966 Q-loop/lid; other site 1126211010967 ABC transporter signature motif; other site 1126211010968 Walker B; other site 1126211010969 D-loop; other site 1126211010970 H-loop/switch region; other site 1126211010971 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1126211010972 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1126211010973 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1126211010974 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1126211010975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1126211010976 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1126211010977 putative dimerization interface [polypeptide binding]; other site 1126211010978 Predicted membrane protein [Function unknown]; Region: COG2855 1126211010979 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1126211010980 putative heme peroxidase; Provisional; Region: PRK12276 1126211010981 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1126211010982 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1126211010983 putative NAD(P) binding site [chemical binding]; other site 1126211010984 putative active site [active] 1126211010985 transaminase; Reviewed; Region: PRK08068 1126211010986 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211010987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211010988 homodimer interface [polypeptide binding]; other site 1126211010989 catalytic residue [active] 1126211010990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211010991 H+ Antiporter protein; Region: 2A0121; TIGR00900 1126211010992 putative substrate translocation pore; other site 1126211010993 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1126211010994 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1126211010995 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1126211010996 classical (c) SDRs; Region: SDR_c; cd05233 1126211010997 NAD(P) binding site [chemical binding]; other site 1126211010998 active site 1126211010999 Cupin domain; Region: Cupin_2; pfam07883 1126211011000 Cupin domain; Region: Cupin_2; pfam07883 1126211011001 Prephenate dehydratase; Region: PDT; pfam00800 1126211011002 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1126211011003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211011004 putative substrate translocation pore; other site 1126211011005 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1126211011006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211011007 putative substrate translocation pore; other site 1126211011008 S-methylmethionine transporter; Provisional; Region: PRK11387 1126211011009 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1126211011010 putative metal binding site [ion binding]; other site 1126211011011 putative dimer interface [polypeptide binding]; other site 1126211011012 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1126211011013 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1126211011014 Glutamate binding site [chemical binding]; other site 1126211011015 homodimer interface [polypeptide binding]; other site 1126211011016 NAD binding site [chemical binding]; other site 1126211011017 catalytic residues [active] 1126211011018 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1126211011019 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1126211011020 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1126211011021 NAD(P) binding site [chemical binding]; other site 1126211011022 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211011023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211011024 dimer interface [polypeptide binding]; other site 1126211011025 phosphorylation site [posttranslational modification] 1126211011026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211011027 ATP binding site [chemical binding]; other site 1126211011028 Mg2+ binding site [ion binding]; other site 1126211011029 G-X-G motif; other site 1126211011030 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211011031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211011032 active site 1126211011033 phosphorylation site [posttranslational modification] 1126211011034 intermolecular recognition site; other site 1126211011035 dimerization interface [polypeptide binding]; other site 1126211011036 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211011037 DNA binding site [nucleotide binding] 1126211011038 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1126211011039 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1126211011040 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1126211011041 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1126211011042 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1126211011043 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1126211011044 Walker A/P-loop; other site 1126211011045 ATP binding site [chemical binding]; other site 1126211011046 Q-loop/lid; other site 1126211011047 ABC transporter signature motif; other site 1126211011048 Walker B; other site 1126211011049 D-loop; other site 1126211011050 H-loop/switch region; other site 1126211011051 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1126211011052 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1126211011053 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1126211011054 NADP binding site [chemical binding]; other site 1126211011055 active site 1126211011056 putative substrate binding site [chemical binding]; other site 1126211011057 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1126211011058 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1126211011059 NAD binding site [chemical binding]; other site 1126211011060 substrate binding site [chemical binding]; other site 1126211011061 homodimer interface [polypeptide binding]; other site 1126211011062 active site 1126211011063 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1126211011064 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1126211011065 substrate binding site; other site 1126211011066 tetramer interface; other site 1126211011067 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1126211011068 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1126211011069 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1126211011070 ligand binding site; other site 1126211011071 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1126211011072 NeuB family; Region: NeuB; pfam03102 1126211011073 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1126211011074 NeuB binding interface [polypeptide binding]; other site 1126211011075 putative substrate binding site [chemical binding]; other site 1126211011076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1126211011077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211011078 Coenzyme A binding pocket [chemical binding]; other site 1126211011079 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1126211011080 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1126211011081 inhibitor-cofactor binding pocket; inhibition site 1126211011082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211011083 catalytic residue [active] 1126211011084 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1126211011085 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1126211011086 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1126211011087 active site 1126211011088 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 1126211011089 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1126211011090 Permease family; Region: Xan_ur_permease; pfam00860 1126211011091 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1126211011092 ligand binding site [chemical binding]; other site 1126211011093 active site 1126211011094 UGI interface [polypeptide binding]; other site 1126211011095 catalytic site [active] 1126211011096 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1126211011097 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1126211011098 active site 1126211011099 Predicted transcriptional regulators [Transcription]; Region: COG1695 1126211011100 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1126211011101 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1126211011102 dimer interface [polypeptide binding]; other site 1126211011103 substrate binding site [chemical binding]; other site 1126211011104 ATP binding site [chemical binding]; other site 1126211011105 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1126211011106 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1126211011107 substrate binding [chemical binding]; other site 1126211011108 active site 1126211011109 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1126211011110 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1126211011111 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1126211011112 active site turn [active] 1126211011113 phosphorylation site [posttranslational modification] 1126211011114 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1126211011115 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1126211011116 CAT RNA binding domain; Region: CAT_RBD; smart01061 1126211011117 PRD domain; Region: PRD; pfam00874 1126211011118 PRD domain; Region: PRD; pfam00874 1126211011119 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1126211011120 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1126211011121 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1126211011122 putative active site [active] 1126211011123 catalytic triad [active] 1126211011124 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1126211011125 PA/protease domain interface [polypeptide binding]; other site 1126211011126 putative integrin binding motif; other site 1126211011127 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1126211011128 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1126211011129 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1126211011130 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1126211011131 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1126211011132 dimer interface [polypeptide binding]; other site 1126211011133 FMN binding site [chemical binding]; other site 1126211011134 NADPH bind site [chemical binding]; other site 1126211011135 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1126211011136 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1126211011137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211011138 Coenzyme A binding pocket [chemical binding]; other site 1126211011139 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1126211011140 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1126211011141 Subunit I/III interface [polypeptide binding]; other site 1126211011142 Subunit III/IV interface [polypeptide binding]; other site 1126211011143 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1126211011144 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1126211011145 D-pathway; other site 1126211011146 Putative ubiquinol binding site [chemical binding]; other site 1126211011147 Low-spin heme (heme b) binding site [chemical binding]; other site 1126211011148 Putative water exit pathway; other site 1126211011149 Binuclear center (heme o3/CuB) [ion binding]; other site 1126211011150 K-pathway; other site 1126211011151 Putative proton exit pathway; other site 1126211011152 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1126211011153 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1126211011154 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1126211011155 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1126211011156 galactokinase; Provisional; Region: PRK05322 1126211011157 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1126211011158 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1126211011159 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1126211011160 Predicted membrane protein [Function unknown]; Region: COG2246 1126211011161 GtrA-like protein; Region: GtrA; pfam04138 1126211011162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211011163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211011164 Anti-repressor SinI; Region: SinI; pfam08671 1126211011165 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1126211011166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211011167 S-adenosylmethionine binding site [chemical binding]; other site 1126211011168 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1126211011169 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1126211011170 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1126211011171 catalytic residues [active] 1126211011172 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1126211011173 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1126211011174 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1126211011175 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1126211011176 thiamine phosphate binding site [chemical binding]; other site 1126211011177 active site 1126211011178 pyrophosphate binding site [ion binding]; other site 1126211011179 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1126211011180 substrate binding site [chemical binding]; other site 1126211011181 multimerization interface [polypeptide binding]; other site 1126211011182 ATP binding site [chemical binding]; other site 1126211011183 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1126211011184 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1126211011185 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1126211011186 putative dimerization interface [polypeptide binding]; other site 1126211011187 holin-like protein; Validated; Region: PRK01658 1126211011188 LrgB-like family; Region: LrgB; cl00596 1126211011189 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1126211011190 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1126211011191 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1126211011192 DNA binding residues [nucleotide binding] 1126211011193 dimer interface [polypeptide binding]; other site 1126211011194 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1126211011195 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1126211011196 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1126211011197 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1126211011198 putative RNA binding site [nucleotide binding]; other site 1126211011199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211011200 S-adenosylmethionine binding site [chemical binding]; other site 1126211011201 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1126211011202 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1126211011203 active site 1126211011204 metal binding site [ion binding]; metal-binding site 1126211011205 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1126211011206 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1126211011207 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1126211011208 active site 1126211011209 catalytic residues [active] 1126211011210 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1126211011211 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1126211011212 Ligand binding site; other site 1126211011213 metal-binding site 1126211011214 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211011215 MarR family; Region: MarR; pfam01047 1126211011216 MarR family; Region: MarR_2; cl17246 1126211011217 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1126211011218 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1126211011219 active site 1126211011220 HIGH motif; other site 1126211011221 dimer interface [polypeptide binding]; other site 1126211011222 KMSKS motif; other site 1126211011223 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1126211011224 RNA binding surface [nucleotide binding]; other site 1126211011225 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1126211011226 synthetase active site [active] 1126211011227 NTP binding site [chemical binding]; other site 1126211011228 metal binding site [ion binding]; metal-binding site 1126211011229 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1126211011230 UbiA prenyltransferase family; Region: UbiA; pfam01040 1126211011231 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1126211011232 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1126211011233 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1126211011234 acyl-activating enzyme (AAE) consensus motif; other site 1126211011235 AMP binding site [chemical binding]; other site 1126211011236 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1126211011237 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1126211011238 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1126211011239 DltD N-terminal region; Region: DltD_N; pfam04915 1126211011240 DltD central region; Region: DltD_M; pfam04918 1126211011241 DltD C-terminal region; Region: DltD_C; pfam04914 1126211011242 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1126211011243 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1126211011244 homodimer interface [polypeptide binding]; other site 1126211011245 substrate-cofactor binding pocket; other site 1126211011246 catalytic residue [active] 1126211011247 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1126211011248 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1126211011249 NAD binding site [chemical binding]; other site 1126211011250 sugar binding site [chemical binding]; other site 1126211011251 divalent metal binding site [ion binding]; other site 1126211011252 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1126211011253 dimer interface [polypeptide binding]; other site 1126211011254 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1126211011255 methionine cluster; other site 1126211011256 active site 1126211011257 phosphorylation site [posttranslational modification] 1126211011258 metal binding site [ion binding]; metal-binding site 1126211011259 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1126211011260 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1126211011261 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1126211011262 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1126211011263 HTH domain; Region: HTH_11; pfam08279 1126211011264 Mga helix-turn-helix domain; Region: Mga; pfam05043 1126211011265 PRD domain; Region: PRD; pfam00874 1126211011266 PRD domain; Region: PRD; pfam00874 1126211011267 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1126211011268 active site 1126211011269 P-loop; other site 1126211011270 phosphorylation site [posttranslational modification] 1126211011271 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1126211011272 active site 1126211011273 phosphorylation site [posttranslational modification] 1126211011274 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1126211011275 active site 1126211011276 DNA binding site [nucleotide binding] 1126211011277 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1126211011278 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1126211011279 ABC-ATPase subunit interface; other site 1126211011280 dimer interface [polypeptide binding]; other site 1126211011281 putative PBP binding regions; other site 1126211011282 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1126211011283 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1126211011284 ABC-ATPase subunit interface; other site 1126211011285 dimer interface [polypeptide binding]; other site 1126211011286 putative PBP binding regions; other site 1126211011287 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1126211011288 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1126211011289 intersubunit interface [polypeptide binding]; other site 1126211011290 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1126211011291 putative DNA binding site [nucleotide binding]; other site 1126211011292 putative Zn2+ binding site [ion binding]; other site 1126211011293 arsenical pump membrane protein; Provisional; Region: PRK15445 1126211011294 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1126211011295 transmembrane helices; other site 1126211011296 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1126211011297 active site 1126211011298 P-loop; other site 1126211011299 phosphorylation site [posttranslational modification] 1126211011300 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1126211011301 active site 1126211011302 methionine cluster; other site 1126211011303 phosphorylation site [posttranslational modification] 1126211011304 metal binding site [ion binding]; metal-binding site 1126211011305 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1126211011306 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1126211011307 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1126211011308 beta-galactosidase; Region: BGL; TIGR03356 1126211011309 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1126211011310 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1126211011311 nucleotide binding site [chemical binding]; other site 1126211011312 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1126211011313 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1126211011314 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1126211011315 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1126211011316 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1126211011317 tetramer interface [polypeptide binding]; other site 1126211011318 heme binding pocket [chemical binding]; other site 1126211011319 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1126211011320 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1126211011321 active site 1126211011322 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1126211011323 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1126211011324 Na binding site [ion binding]; other site 1126211011325 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1126211011326 putative substrate binding site [chemical binding]; other site 1126211011327 putative ATP binding site [chemical binding]; other site 1126211011328 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1126211011329 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1126211011330 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1126211011331 Walker A/P-loop; other site 1126211011332 ATP binding site [chemical binding]; other site 1126211011333 Q-loop/lid; other site 1126211011334 ABC transporter signature motif; other site 1126211011335 Walker B; other site 1126211011336 D-loop; other site 1126211011337 H-loop/switch region; other site 1126211011338 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1126211011339 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1126211011340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211011341 ATP binding site [chemical binding]; other site 1126211011342 Q-loop/lid; other site 1126211011343 ABC transporter signature motif; other site 1126211011344 Walker B; other site 1126211011345 D-loop; other site 1126211011346 H-loop/switch region; other site 1126211011347 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1126211011348 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1126211011349 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1126211011350 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1126211011351 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1126211011352 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1126211011353 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1126211011354 putative active site [active] 1126211011355 putative metal binding site [ion binding]; other site 1126211011356 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1126211011357 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1126211011358 Walker A/P-loop; other site 1126211011359 ATP binding site [chemical binding]; other site 1126211011360 Q-loop/lid; other site 1126211011361 ABC transporter signature motif; other site 1126211011362 Walker B; other site 1126211011363 D-loop; other site 1126211011364 H-loop/switch region; other site 1126211011365 TOBE domain; Region: TOBE; pfam03459 1126211011366 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1126211011367 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1126211011368 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1126211011369 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1126211011370 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1126211011371 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1126211011372 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1126211011373 UDP-glucose 4-epimerase; Region: PLN02240 1126211011374 NAD binding site [chemical binding]; other site 1126211011375 homodimer interface [polypeptide binding]; other site 1126211011376 active site 1126211011377 substrate binding site [chemical binding]; other site 1126211011378 peptidase T; Region: peptidase-T; TIGR01882 1126211011379 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1126211011380 metal binding site [ion binding]; metal-binding site 1126211011381 dimer interface [polypeptide binding]; other site 1126211011382 Tubby C 2; Region: Tub_2; cl02043 1126211011383 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1126211011384 substrate binding site [chemical binding]; other site 1126211011385 THF binding site; other site 1126211011386 zinc-binding site [ion binding]; other site 1126211011387 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1126211011388 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1126211011389 nucleoside transporter; Region: nupC; TIGR00804 1126211011390 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1126211011391 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1126211011392 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1126211011393 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1126211011394 hydroperoxidase II; Provisional; Region: katE; PRK11249 1126211011395 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1126211011396 tetramer interface [polypeptide binding]; other site 1126211011397 heme binding pocket [chemical binding]; other site 1126211011398 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1126211011399 domain interactions; other site 1126211011400 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1126211011401 Citrate transporter; Region: CitMHS; pfam03600 1126211011402 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1126211011403 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1126211011404 active site 1126211011405 active site 1126211011406 catalytic residues [active] 1126211011407 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1126211011408 CAT RNA binding domain; Region: CAT_RBD; smart01061 1126211011409 PRD domain; Region: PRD; pfam00874 1126211011410 PRD domain; Region: PRD; pfam00874 1126211011411 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1126211011412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211011413 putative substrate translocation pore; other site 1126211011414 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1126211011415 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1126211011416 ATP binding site [chemical binding]; other site 1126211011417 Mg++ binding site [ion binding]; other site 1126211011418 motif III; other site 1126211011419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211011420 nucleotide binding region [chemical binding]; other site 1126211011421 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1126211011422 RNA binding site [nucleotide binding]; other site 1126211011423 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1126211011424 YxiJ-like protein; Region: YxiJ; pfam14176 1126211011425 RHS Repeat; Region: RHS_repeat; pfam05593 1126211011426 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1126211011427 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1126211011428 RHS Repeat; Region: RHS_repeat; pfam05593 1126211011429 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1126211011430 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1126211011431 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1126211011432 Amb_all domain; Region: Amb_all; smart00656 1126211011433 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1126211011434 EamA-like transporter family; Region: EamA; pfam00892 1126211011435 EamA-like transporter family; Region: EamA; pfam00892 1126211011436 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1126211011437 Ligand Binding Site [chemical binding]; other site 1126211011438 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b; cd09180 1126211011439 PLD-like domain; Region: PLDc_2; pfam13091 1126211011440 putative homodimer interface [polypeptide binding]; other site 1126211011441 putative active site [active] 1126211011442 catalytic site [active] 1126211011443 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1126211011444 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1126211011445 ATP binding site [chemical binding]; other site 1126211011446 putative Mg++ binding site [ion binding]; other site 1126211011447 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1126211011448 nucleotide binding region [chemical binding]; other site 1126211011449 ATP-binding site [chemical binding]; other site 1126211011450 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1126211011451 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1126211011452 active site 1126211011453 8-oxo-dGMP binding site [chemical binding]; other site 1126211011454 nudix motif; other site 1126211011455 metal binding site [ion binding]; metal-binding site 1126211011456 AAA domain; Region: AAA_11; pfam13086 1126211011457 Part of AAA domain; Region: AAA_19; pfam13245 1126211011458 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1126211011459 AAA domain; Region: AAA_12; pfam13087 1126211011460 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 1126211011461 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1126211011462 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1126211011463 substrate binding site [chemical binding]; other site 1126211011464 active site 1126211011465 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1126211011466 hexamer interface [polypeptide binding]; other site 1126211011467 RNA binding site [nucleotide binding]; other site 1126211011468 Histidine-zinc binding site [chemical binding]; other site 1126211011469 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1126211011470 active sites [active] 1126211011471 tetramer interface [polypeptide binding]; other site 1126211011472 urocanate hydratase; Provisional; Region: PRK05414 1126211011473 imidazolonepropionase; Validated; Region: PRK09356 1126211011474 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1126211011475 active site 1126211011476 Agmatinase-like family; Region: Agmatinase-like; cd09990 1126211011477 agmatinase; Region: agmatinase; TIGR01230 1126211011478 active site 1126211011479 oligomer interface [polypeptide binding]; other site 1126211011480 Mn binding site [ion binding]; other site 1126211011481 S-methylmethionine transporter; Provisional; Region: PRK11387 1126211011482 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1126211011483 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1126211011484 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1126211011485 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1126211011486 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1126211011487 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1126211011488 Nucleoside recognition; Region: Gate; pfam07670 1126211011489 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1126211011490 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1126211011491 intersubunit interface [polypeptide binding]; other site 1126211011492 active site 1126211011493 catalytic residue [active] 1126211011494 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1126211011495 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1126211011496 non-specific DNA interactions [nucleotide binding]; other site 1126211011497 DNA binding site [nucleotide binding] 1126211011498 sequence specific DNA binding site [nucleotide binding]; other site 1126211011499 putative cAMP binding site [chemical binding]; other site 1126211011500 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1126211011501 sugar phosphate phosphatase; Provisional; Region: PRK10513 1126211011502 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211011503 active site 1126211011504 motif I; other site 1126211011505 motif II; other site 1126211011506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211011507 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1126211011508 SlyX; Region: SlyX; cl01090 1126211011509 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1126211011510 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1126211011511 putative ligand binding residues [chemical binding]; other site 1126211011512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1126211011513 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1126211011514 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1126211011515 Walker A/P-loop; other site 1126211011516 ATP binding site [chemical binding]; other site 1126211011517 Q-loop/lid; other site 1126211011518 ABC transporter signature motif; other site 1126211011519 Walker B; other site 1126211011520 D-loop; other site 1126211011521 H-loop/switch region; other site 1126211011522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211011523 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1126211011524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211011525 ATP binding site [chemical binding]; other site 1126211011526 Mg2+ binding site [ion binding]; other site 1126211011527 G-X-G motif; other site 1126211011528 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211011529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211011530 active site 1126211011531 phosphorylation site [posttranslational modification] 1126211011532 intermolecular recognition site; other site 1126211011533 dimerization interface [polypeptide binding]; other site 1126211011534 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211011535 DNA binding site [nucleotide binding] 1126211011536 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211011537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211011538 dimer interface [polypeptide binding]; other site 1126211011539 phosphorylation site [posttranslational modification] 1126211011540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211011541 ATP binding site [chemical binding]; other site 1126211011542 Mg2+ binding site [ion binding]; other site 1126211011543 G-X-G motif; other site 1126211011544 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211011545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211011546 active site 1126211011547 phosphorylation site [posttranslational modification] 1126211011548 intermolecular recognition site; other site 1126211011549 dimerization interface [polypeptide binding]; other site 1126211011550 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211011551 DNA binding site [nucleotide binding] 1126211011552 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1126211011553 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1126211011554 Walker A/P-loop; other site 1126211011555 ATP binding site [chemical binding]; other site 1126211011556 Q-loop/lid; other site 1126211011557 ABC transporter signature motif; other site 1126211011558 Walker B; other site 1126211011559 D-loop; other site 1126211011560 H-loop/switch region; other site 1126211011561 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1126211011562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1126211011563 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1126211011564 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1126211011565 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1126211011566 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211011567 DNA binding site [nucleotide binding] 1126211011568 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 1126211011569 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1126211011570 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 1126211011571 active site 1126211011572 zinc binding site [ion binding]; other site 1126211011573 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1126211011574 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39F; cd02425 1126211011575 putative active site [active] 1126211011576 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1126211011577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211011578 Walker A/P-loop; other site 1126211011579 ATP binding site [chemical binding]; other site 1126211011580 Q-loop/lid; other site 1126211011581 ABC transporter signature motif; other site 1126211011582 Walker B; other site 1126211011583 D-loop; other site 1126211011584 H-loop/switch region; other site 1126211011585 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1126211011586 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1126211011587 intersubunit interface [polypeptide binding]; other site 1126211011588 active site 1126211011589 zinc binding site [ion binding]; other site 1126211011590 Na+ binding site [ion binding]; other site 1126211011591 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1126211011592 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1126211011593 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1126211011594 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1126211011595 DNA interaction; other site 1126211011596 Metal-binding active site; metal-binding site 1126211011597 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1126211011598 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1126211011599 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1126211011600 Glucuronate isomerase; Region: UxaC; cl00829 1126211011601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211011602 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211011603 putative substrate translocation pore; other site 1126211011604 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1126211011605 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1126211011606 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1126211011607 PYR/PP interface [polypeptide binding]; other site 1126211011608 dimer interface [polypeptide binding]; other site 1126211011609 TPP binding site [chemical binding]; other site 1126211011610 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1126211011611 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1126211011612 TPP-binding site; other site 1126211011613 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1126211011614 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1126211011615 substrate binding site [chemical binding]; other site 1126211011616 ATP binding site [chemical binding]; other site 1126211011617 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1126211011618 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1126211011619 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1126211011620 tetrameric interface [polypeptide binding]; other site 1126211011621 NAD binding site [chemical binding]; other site 1126211011622 catalytic residues [active] 1126211011623 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1126211011624 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1126211011625 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1126211011626 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1126211011627 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1126211011628 active site 1126211011629 catalytic tetrad [active] 1126211011630 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1126211011631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211011632 putative substrate translocation pore; other site 1126211011633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211011634 heat shock protein 90; Provisional; Region: PRK05218 1126211011635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211011636 ATP binding site [chemical binding]; other site 1126211011637 Mg2+ binding site [ion binding]; other site 1126211011638 G-X-G motif; other site 1126211011639 short chain dehydrogenase; Validated; Region: PRK08589 1126211011640 classical (c) SDRs; Region: SDR_c; cd05233 1126211011641 NAD(P) binding site [chemical binding]; other site 1126211011642 active site 1126211011643 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1126211011644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211011645 active site 1126211011646 phosphorylation site [posttranslational modification] 1126211011647 intermolecular recognition site; other site 1126211011648 dimerization interface [polypeptide binding]; other site 1126211011649 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1126211011650 DNA binding residues [nucleotide binding] 1126211011651 dimerization interface [polypeptide binding]; other site 1126211011652 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1126211011653 Histidine kinase; Region: HisKA_3; pfam07730 1126211011654 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1126211011655 ATP binding site [chemical binding]; other site 1126211011656 Mg2+ binding site [ion binding]; other site 1126211011657 G-X-G motif; other site 1126211011658 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1126211011659 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1126211011660 putative di-iron ligands [ion binding]; other site 1126211011661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211011662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211011663 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1126211011664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1126211011665 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1126211011666 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1126211011667 NAD(P) binding site [chemical binding]; other site 1126211011668 catalytic residues [active] 1126211011669 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1126211011670 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1126211011671 Trp docking motif [polypeptide binding]; other site 1126211011672 active site 1126211011673 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1126211011674 putative DNA binding site [nucleotide binding]; other site 1126211011675 dimerization interface [polypeptide binding]; other site 1126211011676 putative Zn2+ binding site [ion binding]; other site 1126211011677 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1126211011678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211011679 putative substrate translocation pore; other site 1126211011680 RDD family; Region: RDD; pfam06271 1126211011681 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1126211011682 active site 1126211011683 peroxiredoxin; Region: AhpC; TIGR03137 1126211011684 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1126211011685 dimer interface [polypeptide binding]; other site 1126211011686 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1126211011687 catalytic triad [active] 1126211011688 peroxidatic and resolving cysteines [active] 1126211011689 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1126211011690 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1126211011691 catalytic residue [active] 1126211011692 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1126211011693 catalytic residues [active] 1126211011694 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1126211011695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1126211011696 Fic family protein [Function unknown]; Region: COG3177 1126211011697 Fic/DOC family; Region: Fic; pfam02661 1126211011698 putative proline-specific permease; Provisional; Region: proY; PRK10580 1126211011699 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1126211011700 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1126211011701 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1126211011702 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1126211011703 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1126211011704 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1126211011705 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1126211011706 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1126211011707 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1126211011708 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1126211011709 Ligand binding site; other site 1126211011710 metal-binding site 1126211011711 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1126211011712 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1126211011713 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1126211011714 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1126211011715 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1126211011716 AAA domain; Region: AAA_12; pfam13087 1126211011717 Protein of unknown function DUF262; Region: DUF262; cl14890 1126211011718 FRG domain; Region: FRG; pfam08867 1126211011719 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1126211011720 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1126211011721 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1126211011722 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1126211011723 active site 1126211011724 catalytic tetrad [active] 1126211011725 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1126211011726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211011727 Coenzyme A binding pocket [chemical binding]; other site 1126211011728 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1126211011729 binding surface 1126211011730 TPR motif; other site 1126211011731 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211011732 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1126211011733 Arginase family; Region: Arginase; cd09989 1126211011734 agmatinase; Region: agmatinase; TIGR01230 1126211011735 active site 1126211011736 Mn binding site [ion binding]; other site 1126211011737 oligomer interface [polypeptide binding]; other site 1126211011738 S-methylmethionine transporter; Provisional; Region: PRK11387 1126211011739 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1126211011740 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1126211011741 inhibitor-cofactor binding pocket; inhibition site 1126211011742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211011743 catalytic residue [active] 1126211011744 PAS domain; Region: PAS_9; pfam13426 1126211011745 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1126211011746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1126211011747 Walker A motif; other site 1126211011748 ATP binding site [chemical binding]; other site 1126211011749 Walker B motif; other site 1126211011750 arginine finger; other site 1126211011751 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1126211011752 Cupin-like domain; Region: Cupin_8; pfam13621 1126211011753 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1126211011754 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1126211011755 Walker A/P-loop; other site 1126211011756 ATP binding site [chemical binding]; other site 1126211011757 Q-loop/lid; other site 1126211011758 ABC transporter signature motif; other site 1126211011759 Walker B; other site 1126211011760 D-loop; other site 1126211011761 H-loop/switch region; other site 1126211011762 ABC transporter; Region: ABC_tran_2; pfam12848 1126211011763 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1126211011764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211011765 putative substrate translocation pore; other site 1126211011766 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1126211011767 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1126211011768 hypothetical protein; Provisional; Region: PRK08328 1126211011769 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1126211011770 ATP binding site [chemical binding]; other site 1126211011771 substrate interface [chemical binding]; other site 1126211011772 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1126211011773 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1126211011774 dimerization interface [polypeptide binding]; other site 1126211011775 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211011776 dimer interface [polypeptide binding]; other site 1126211011777 phosphorylation site [posttranslational modification] 1126211011778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211011779 ATP binding site [chemical binding]; other site 1126211011780 Mg2+ binding site [ion binding]; other site 1126211011781 G-X-G motif; other site 1126211011782 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211011783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211011784 active site 1126211011785 phosphorylation site [posttranslational modification] 1126211011786 intermolecular recognition site; other site 1126211011787 dimerization interface [polypeptide binding]; other site 1126211011788 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211011789 DNA binding site [nucleotide binding] 1126211011790 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1126211011791 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1126211011792 protein binding site [polypeptide binding]; other site 1126211011793 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1126211011794 YycH protein; Region: YycI; cl02015 1126211011795 YycH protein; Region: YycH; pfam07435 1126211011796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1126211011797 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1126211011798 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1126211011799 dimerization interface [polypeptide binding]; other site 1126211011800 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1126211011801 putative active site [active] 1126211011802 heme pocket [chemical binding]; other site 1126211011803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1126211011804 dimer interface [polypeptide binding]; other site 1126211011805 phosphorylation site [posttranslational modification] 1126211011806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1126211011807 ATP binding site [chemical binding]; other site 1126211011808 Mg2+ binding site [ion binding]; other site 1126211011809 G-X-G motif; other site 1126211011810 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1126211011811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1126211011812 active site 1126211011813 phosphorylation site [posttranslational modification] 1126211011814 intermolecular recognition site; other site 1126211011815 dimerization interface [polypeptide binding]; other site 1126211011816 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1126211011817 DNA binding site [nucleotide binding] 1126211011818 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1126211011819 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1126211011820 GDP-binding site [chemical binding]; other site 1126211011821 ACT binding site; other site 1126211011822 IMP binding site; other site 1126211011823 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1126211011824 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1126211011825 active site 1126211011826 replicative DNA helicase; Provisional; Region: PRK05748 1126211011827 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1126211011828 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1126211011829 Walker A motif; other site 1126211011830 ATP binding site [chemical binding]; other site 1126211011831 Walker B motif; other site 1126211011832 DNA binding loops [nucleotide binding] 1126211011833 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1126211011834 YycC-like protein; Region: YycC; pfam14174 1126211011835 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1126211011836 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1126211011837 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1126211011838 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1126211011839 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1126211011840 Phosphotransferase enzyme family; Region: APH; pfam01636 1126211011841 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1126211011842 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1126211011843 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1126211011844 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1126211011845 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1126211011846 active site 1126211011847 substrate binding site [chemical binding]; other site 1126211011848 ATP binding site [chemical binding]; other site 1126211011849 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1126211011850 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1126211011851 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1126211011852 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1126211011853 diguanylate cyclase; Region: GGDEF; smart00267 1126211011854 DHH family; Region: DHH; pfam01368 1126211011855 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 1126211011856 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1126211011857 Predicted transcriptional regulators [Transcription]; Region: COG1733 1126211011858 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1126211011859 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1126211011860 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1126211011861 DHHA2 domain; Region: DHHA2; pfam02833 1126211011862 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1126211011863 EamA-like transporter family; Region: EamA; pfam00892 1126211011864 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1126211011865 active site 1126211011866 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1126211011867 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1126211011868 substrate binding [chemical binding]; other site 1126211011869 active site 1126211011870 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1126211011871 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1126211011872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211011873 DNA-binding site [nucleotide binding]; DNA binding site 1126211011874 FCD domain; Region: FCD; pfam07729 1126211011875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1126211011876 DinB superfamily; Region: DinB_2; pfam12867 1126211011877 H+ Antiporter protein; Region: 2A0121; TIGR00900 1126211011878 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1126211011879 EamA-like transporter family; Region: EamA; pfam00892 1126211011880 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1126211011881 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1126211011882 dimer interface [polypeptide binding]; other site 1126211011883 FMN binding site [chemical binding]; other site 1126211011884 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211011885 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1126211011886 putative DNA binding site [nucleotide binding]; other site 1126211011887 putative Zn2+ binding site [ion binding]; other site 1126211011888 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1126211011889 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1126211011890 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1126211011891 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1126211011892 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1126211011893 MarR family; Region: MarR; pfam01047 1126211011894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211011895 Coenzyme A binding pocket [chemical binding]; other site 1126211011896 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1126211011897 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1126211011898 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1126211011899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1126211011900 active site 1126211011901 motif I; other site 1126211011902 motif II; other site 1126211011903 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1126211011904 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1126211011905 active site 1126211011906 catalytic residues [active] 1126211011907 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1126211011908 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1126211011909 DNA-binding site [nucleotide binding]; DNA binding site 1126211011910 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1126211011911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1126211011912 homodimer interface [polypeptide binding]; other site 1126211011913 catalytic residue [active] 1126211011914 EamA-like transporter family; Region: EamA; pfam00892 1126211011915 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1126211011916 EamA-like transporter family; Region: EamA; pfam00892 1126211011917 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1126211011918 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1126211011919 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1126211011920 CAAX protease self-immunity; Region: Abi; pfam02517 1126211011921 benzoate transport; Region: 2A0115; TIGR00895 1126211011922 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211011923 putative substrate translocation pore; other site 1126211011924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1126211011925 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1126211011926 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1126211011927 putative metal binding site [ion binding]; other site 1126211011928 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1126211011929 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1126211011930 DNA binding site [nucleotide binding] 1126211011931 domain linker motif; other site 1126211011932 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1126211011933 putative dimerization interface [polypeptide binding]; other site 1126211011934 putative ligand binding site [chemical binding]; other site 1126211011935 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1126211011936 putative metal binding site [ion binding]; other site 1126211011937 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1126211011938 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1126211011939 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1126211011940 DNA binding site [nucleotide binding] 1126211011941 active site 1126211011942 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1126211011943 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1126211011944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1126211011945 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1126211011946 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1126211011947 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1126211011948 dimer interface [polypeptide binding]; other site 1126211011949 ssDNA binding site [nucleotide binding]; other site 1126211011950 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1126211011951 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1126211011952 GTP-binding protein YchF; Reviewed; Region: PRK09601 1126211011953 YchF GTPase; Region: YchF; cd01900 1126211011954 G1 box; other site 1126211011955 GTP/Mg2+ binding site [chemical binding]; other site 1126211011956 Switch I region; other site 1126211011957 G2 box; other site 1126211011958 Switch II region; other site 1126211011959 G3 box; other site 1126211011960 G4 box; other site 1126211011961 G5 box; other site 1126211011962 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1126211011963 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1126211011964 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1126211011965 putative [4Fe-4S] binding site [ion binding]; other site 1126211011966 putative molybdopterin cofactor binding site [chemical binding]; other site 1126211011967 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1126211011968 molybdopterin cofactor binding site; other site 1126211011969 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1126211011970 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1126211011971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1126211011972 Coenzyme A binding pocket [chemical binding]; other site 1126211011973 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1126211011974 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1126211011975 ParB-like nuclease domain; Region: ParB; smart00470 1126211011976 KorB domain; Region: KorB; pfam08535 1126211011977 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1126211011978 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1126211011979 P-loop; other site 1126211011980 Magnesium ion binding site [ion binding]; other site 1126211011981 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1126211011982 Magnesium ion binding site [ion binding]; other site 1126211011983 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1126211011984 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1126211011985 ParB-like nuclease domain; Region: ParB; smart00470 1126211011986 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1126211011987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1126211011988 S-adenosylmethionine binding site [chemical binding]; other site 1126211011989 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1126211011990 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1126211011991 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1126211011992 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1126211011993 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1126211011994 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1126211011995 G1 box; other site 1126211011996 GTP/Mg2+ binding site [chemical binding]; other site 1126211011997 Switch I region; other site 1126211011998 G2 box; other site 1126211011999 Switch II region; other site 1126211012000 G3 box; other site 1126211012001 G4 box; other site 1126211012002 G5 box; other site 1126211012003 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1126211012004 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1126211012005 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1126211012006 G-X-X-G motif; other site 1126211012007 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1126211012008 RxxxH motif; other site 1126211012009 OxaA-like protein precursor; Validated; Region: PRK02944 1126211012010 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1126211012011 ribonuclease P; Reviewed; Region: rnpA; PRK00499