-- dump date 20140618_211230 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1225788000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1225788000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1225788000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788000004 Walker A motif; other site 1225788000005 ATP binding site [chemical binding]; other site 1225788000006 Walker B motif; other site 1225788000007 arginine finger; other site 1225788000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1225788000009 DnaA box-binding interface [nucleotide binding]; other site 1225788000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1225788000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1225788000012 putative DNA binding surface [nucleotide binding]; other site 1225788000013 dimer interface [polypeptide binding]; other site 1225788000014 beta-clamp/clamp loader binding surface; other site 1225788000015 beta-clamp/translesion DNA polymerase binding surface; other site 1225788000016 S4 domain; Region: S4_2; pfam13275 1225788000017 recombination protein F; Reviewed; Region: recF; PRK00064 1225788000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1225788000019 Walker A/P-loop; other site 1225788000020 ATP binding site [chemical binding]; other site 1225788000021 Q-loop/lid; other site 1225788000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1225788000023 ABC transporter signature motif; other site 1225788000024 Walker B; other site 1225788000025 D-loop; other site 1225788000026 H-loop/switch region; other site 1225788000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1225788000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788000029 ATP binding site [chemical binding]; other site 1225788000030 Mg2+ binding site [ion binding]; other site 1225788000031 G-X-G motif; other site 1225788000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1225788000033 anchoring element; other site 1225788000034 dimer interface [polypeptide binding]; other site 1225788000035 ATP binding site [chemical binding]; other site 1225788000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1225788000037 active site 1225788000038 putative metal-binding site [ion binding]; other site 1225788000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1225788000040 DNA gyrase subunit A; Validated; Region: PRK05560 1225788000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1225788000042 CAP-like domain; other site 1225788000043 active site 1225788000044 primary dimer interface [polypeptide binding]; other site 1225788000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1225788000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1225788000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1225788000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1225788000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1225788000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1225788000051 YaaC-like Protein; Region: YaaC; pfam14175 1225788000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1225788000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1225788000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1225788000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1225788000056 active site 1225788000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1225788000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1225788000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1225788000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1225788000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1225788000062 active site 1225788000063 multimer interface [polypeptide binding]; other site 1225788000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1225788000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1225788000066 predicted active site [active] 1225788000067 catalytic triad [active] 1225788000068 seryl-tRNA synthetase; Provisional; Region: PRK05431 1225788000069 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1225788000070 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1225788000071 dimer interface [polypeptide binding]; other site 1225788000072 active site 1225788000073 motif 1; other site 1225788000074 motif 2; other site 1225788000075 motif 3; other site 1225788000076 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1225788000077 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1225788000078 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1225788000079 Substrate-binding site [chemical binding]; other site 1225788000080 Substrate specificity [chemical binding]; other site 1225788000081 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1225788000082 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1225788000083 Substrate-binding site [chemical binding]; other site 1225788000084 Substrate specificity [chemical binding]; other site 1225788000085 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1225788000086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788000087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788000088 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1225788000089 active site 1225788000090 Isochorismatase family; Region: Isochorismatase; pfam00857 1225788000091 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1225788000092 catalytic triad [active] 1225788000093 conserved cis-peptide bond; other site 1225788000094 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1225788000095 nucleoside/Zn binding site; other site 1225788000096 dimer interface [polypeptide binding]; other site 1225788000097 catalytic motif [active] 1225788000098 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1225788000099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788000100 Walker A motif; other site 1225788000101 ATP binding site [chemical binding]; other site 1225788000102 Walker B motif; other site 1225788000103 arginine finger; other site 1225788000104 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1225788000105 hypothetical protein; Validated; Region: PRK00153 1225788000106 recombination protein RecR; Reviewed; Region: recR; PRK00076 1225788000107 RecR protein; Region: RecR; pfam02132 1225788000108 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1225788000109 putative active site [active] 1225788000110 putative metal-binding site [ion binding]; other site 1225788000111 tetramer interface [polypeptide binding]; other site 1225788000112 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1225788000113 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 1225788000114 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1225788000115 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 1225788000116 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1225788000117 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1225788000118 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1225788000119 homodimer interface [polypeptide binding]; other site 1225788000120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788000121 catalytic residue [active] 1225788000122 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1225788000123 thymidylate kinase; Validated; Region: tmk; PRK00698 1225788000124 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1225788000125 TMP-binding site; other site 1225788000126 ATP-binding site [chemical binding]; other site 1225788000127 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1225788000128 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1225788000129 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1225788000130 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1225788000131 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1225788000132 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1225788000133 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1225788000134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788000135 S-adenosylmethionine binding site [chemical binding]; other site 1225788000136 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1225788000137 GIY-YIG motif/motif A; other site 1225788000138 putative active site [active] 1225788000139 putative metal binding site [ion binding]; other site 1225788000140 Predicted methyltransferases [General function prediction only]; Region: COG0313 1225788000141 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1225788000142 putative SAM binding site [chemical binding]; other site 1225788000143 putative homodimer interface [polypeptide binding]; other site 1225788000144 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1225788000145 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1225788000146 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1225788000147 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1225788000148 active site 1225788000149 HIGH motif; other site 1225788000150 KMSKS motif; other site 1225788000151 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1225788000152 tRNA binding surface [nucleotide binding]; other site 1225788000153 anticodon binding site; other site 1225788000154 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1225788000155 dimer interface [polypeptide binding]; other site 1225788000156 putative tRNA-binding site [nucleotide binding]; other site 1225788000157 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1225788000158 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1225788000159 active site 1225788000160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1225788000161 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1225788000162 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1225788000163 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1225788000164 G5 domain; Region: G5; pfam07501 1225788000165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1225788000166 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1225788000167 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1225788000168 putative active site [active] 1225788000169 putative metal binding site [ion binding]; other site 1225788000170 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1225788000171 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1225788000172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788000173 S-adenosylmethionine binding site [chemical binding]; other site 1225788000174 YabG peptidase U57; Region: Peptidase_U57; pfam05582 1225788000175 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1225788000176 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1225788000177 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1225788000178 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1225788000179 pur operon repressor; Provisional; Region: PRK09213 1225788000180 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1225788000181 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1225788000182 active site 1225788000183 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1225788000184 homotrimer interaction site [polypeptide binding]; other site 1225788000185 putative active site [active] 1225788000186 regulatory protein SpoVG; Reviewed; Region: PRK13259 1225788000187 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1225788000188 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1225788000189 Substrate binding site; other site 1225788000190 Mg++ binding site; other site 1225788000191 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1225788000192 active site 1225788000193 substrate binding site [chemical binding]; other site 1225788000194 CoA binding site [chemical binding]; other site 1225788000195 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1225788000196 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1225788000197 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1225788000198 active site 1225788000199 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1225788000200 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1225788000201 5S rRNA interface [nucleotide binding]; other site 1225788000202 CTC domain interface [polypeptide binding]; other site 1225788000203 L16 interface [polypeptide binding]; other site 1225788000204 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1225788000205 putative active site [active] 1225788000206 catalytic residue [active] 1225788000207 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1225788000208 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1225788000209 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1225788000210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1225788000211 ATP binding site [chemical binding]; other site 1225788000212 putative Mg++ binding site [ion binding]; other site 1225788000213 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1225788000214 nucleotide binding region [chemical binding]; other site 1225788000215 ATP-binding site [chemical binding]; other site 1225788000216 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1225788000217 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1225788000218 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1225788000219 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1225788000220 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1225788000221 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1225788000222 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1225788000223 putative SAM binding site [chemical binding]; other site 1225788000224 putative homodimer interface [polypeptide binding]; other site 1225788000225 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1225788000226 homodimer interface [polypeptide binding]; other site 1225788000227 metal binding site [ion binding]; metal-binding site 1225788000228 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1225788000229 homodimer interface [polypeptide binding]; other site 1225788000230 active site 1225788000231 putative chemical substrate binding site [chemical binding]; other site 1225788000232 metal binding site [ion binding]; metal-binding site 1225788000233 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1225788000234 RNA binding surface [nucleotide binding]; other site 1225788000235 sporulation protein YabP; Region: spore_yabP; TIGR02892 1225788000236 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1225788000237 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1225788000238 Septum formation initiator; Region: DivIC; pfam04977 1225788000239 hypothetical protein; Provisional; Region: PRK08582 1225788000240 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1225788000241 RNA binding site [nucleotide binding]; other site 1225788000242 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1225788000243 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1225788000244 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1225788000245 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1225788000246 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1225788000247 metal ion-dependent adhesion site (MIDAS); other site 1225788000248 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1225788000249 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1225788000250 active site 1225788000251 ATP binding site [chemical binding]; other site 1225788000252 substrate binding site [chemical binding]; other site 1225788000253 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1225788000254 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1225788000255 Ligand Binding Site [chemical binding]; other site 1225788000256 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1225788000257 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1225788000258 active site 1225788000259 FtsH Extracellular; Region: FtsH_ext; pfam06480 1225788000260 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1225788000261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788000262 Walker A motif; other site 1225788000263 ATP binding site [chemical binding]; other site 1225788000264 Walker B motif; other site 1225788000265 arginine finger; other site 1225788000266 Peptidase family M41; Region: Peptidase_M41; pfam01434 1225788000267 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1225788000268 nucleotide binding site [chemical binding]; other site 1225788000269 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1225788000270 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1225788000271 dimerization interface [polypeptide binding]; other site 1225788000272 domain crossover interface; other site 1225788000273 redox-dependent activation switch; other site 1225788000274 SurA N-terminal domain; Region: SurA_N_3; cl07813 1225788000275 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1225788000276 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1225788000277 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1225788000278 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1225788000279 dimer interface [polypeptide binding]; other site 1225788000280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788000281 catalytic residue [active] 1225788000282 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1225788000283 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1225788000284 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1225788000285 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1225788000286 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1225788000287 glutamine binding [chemical binding]; other site 1225788000288 catalytic triad [active] 1225788000289 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1225788000290 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1225788000291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788000292 catalytic residue [active] 1225788000293 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1225788000294 dihydropteroate synthase; Region: DHPS; TIGR01496 1225788000295 substrate binding pocket [chemical binding]; other site 1225788000296 dimer interface [polypeptide binding]; other site 1225788000297 inhibitor binding site; inhibition site 1225788000298 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1225788000299 homooctamer interface [polypeptide binding]; other site 1225788000300 active site 1225788000301 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1225788000302 catalytic center binding site [active] 1225788000303 ATP binding site [chemical binding]; other site 1225788000304 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1225788000305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788000306 non-specific DNA binding site [nucleotide binding]; other site 1225788000307 salt bridge; other site 1225788000308 sequence-specific DNA binding site [nucleotide binding]; other site 1225788000309 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1225788000310 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1225788000311 FMN binding site [chemical binding]; other site 1225788000312 active site 1225788000313 catalytic residues [active] 1225788000314 substrate binding site [chemical binding]; other site 1225788000315 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1225788000316 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1225788000317 dimer interface [polypeptide binding]; other site 1225788000318 putative anticodon binding site; other site 1225788000319 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1225788000320 motif 1; other site 1225788000321 active site 1225788000322 motif 2; other site 1225788000323 motif 3; other site 1225788000324 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1225788000325 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1225788000326 UvrB/uvrC motif; Region: UVR; pfam02151 1225788000327 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1225788000328 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1225788000329 ADP binding site [chemical binding]; other site 1225788000330 phosphagen binding site; other site 1225788000331 substrate specificity loop; other site 1225788000332 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1225788000333 Clp amino terminal domain; Region: Clp_N; pfam02861 1225788000334 Clp amino terminal domain; Region: Clp_N; pfam02861 1225788000335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788000336 Walker A motif; other site 1225788000337 ATP binding site [chemical binding]; other site 1225788000338 Walker B motif; other site 1225788000339 arginine finger; other site 1225788000340 UvrB/uvrC motif; Region: UVR; pfam02151 1225788000341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788000342 Walker A motif; other site 1225788000343 ATP binding site [chemical binding]; other site 1225788000344 Walker B motif; other site 1225788000345 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1225788000346 DNA repair protein RadA; Provisional; Region: PRK11823 1225788000347 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1225788000348 Walker A motif/ATP binding site; other site 1225788000349 ATP binding site [chemical binding]; other site 1225788000350 Walker B motif; other site 1225788000351 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1225788000352 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1225788000353 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1225788000354 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1225788000355 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1225788000356 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1225788000357 putative active site [active] 1225788000358 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1225788000359 substrate binding site; other site 1225788000360 dimer interface; other site 1225788000361 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1225788000362 homotrimer interaction site [polypeptide binding]; other site 1225788000363 zinc binding site [ion binding]; other site 1225788000364 CDP-binding sites; other site 1225788000365 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1225788000366 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1225788000367 HIGH motif; other site 1225788000368 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1225788000369 active site 1225788000370 KMSKS motif; other site 1225788000371 serine O-acetyltransferase; Region: cysE; TIGR01172 1225788000372 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1225788000373 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1225788000374 trimer interface [polypeptide binding]; other site 1225788000375 active site 1225788000376 substrate binding site [chemical binding]; other site 1225788000377 CoA binding site [chemical binding]; other site 1225788000378 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1225788000379 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1225788000380 active site 1225788000381 HIGH motif; other site 1225788000382 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1225788000383 KMSKS motif; other site 1225788000384 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1225788000385 tRNA binding surface [nucleotide binding]; other site 1225788000386 anticodon binding site; other site 1225788000387 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1225788000388 active site 1225788000389 metal binding site [ion binding]; metal-binding site 1225788000390 dimerization interface [polypeptide binding]; other site 1225788000391 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1225788000392 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1225788000393 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1225788000394 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1225788000395 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1225788000396 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1225788000397 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1225788000398 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1225788000399 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1225788000400 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1225788000401 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1225788000402 putative homodimer interface [polypeptide binding]; other site 1225788000403 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1225788000404 heterodimer interface [polypeptide binding]; other site 1225788000405 homodimer interface [polypeptide binding]; other site 1225788000406 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1225788000407 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1225788000408 23S rRNA interface [nucleotide binding]; other site 1225788000409 L7/L12 interface [polypeptide binding]; other site 1225788000410 putative thiostrepton binding site; other site 1225788000411 L25 interface [polypeptide binding]; other site 1225788000412 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1225788000413 mRNA/rRNA interface [nucleotide binding]; other site 1225788000414 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1225788000415 23S rRNA interface [nucleotide binding]; other site 1225788000416 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1225788000417 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1225788000418 core dimer interface [polypeptide binding]; other site 1225788000419 peripheral dimer interface [polypeptide binding]; other site 1225788000420 L10 interface [polypeptide binding]; other site 1225788000421 L11 interface [polypeptide binding]; other site 1225788000422 putative EF-Tu interaction site [polypeptide binding]; other site 1225788000423 putative EF-G interaction site [polypeptide binding]; other site 1225788000424 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1225788000425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788000426 S-adenosylmethionine binding site [chemical binding]; other site 1225788000427 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1225788000428 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1225788000429 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1225788000430 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1225788000431 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1225788000432 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1225788000433 RPB1 interaction site [polypeptide binding]; other site 1225788000434 RPB10 interaction site [polypeptide binding]; other site 1225788000435 RPB11 interaction site [polypeptide binding]; other site 1225788000436 RPB3 interaction site [polypeptide binding]; other site 1225788000437 RPB12 interaction site [polypeptide binding]; other site 1225788000438 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1225788000439 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1225788000440 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1225788000441 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1225788000442 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1225788000443 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1225788000444 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1225788000445 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1225788000446 G-loop; other site 1225788000447 DNA binding site [nucleotide binding] 1225788000448 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1225788000449 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1225788000450 S17 interaction site [polypeptide binding]; other site 1225788000451 S8 interaction site; other site 1225788000452 16S rRNA interaction site [nucleotide binding]; other site 1225788000453 streptomycin interaction site [chemical binding]; other site 1225788000454 23S rRNA interaction site [nucleotide binding]; other site 1225788000455 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1225788000456 30S ribosomal protein S7; Validated; Region: PRK05302 1225788000457 elongation factor G; Reviewed; Region: PRK00007 1225788000458 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1225788000459 G1 box; other site 1225788000460 putative GEF interaction site [polypeptide binding]; other site 1225788000461 GTP/Mg2+ binding site [chemical binding]; other site 1225788000462 Switch I region; other site 1225788000463 G2 box; other site 1225788000464 G3 box; other site 1225788000465 Switch II region; other site 1225788000466 G4 box; other site 1225788000467 G5 box; other site 1225788000468 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1225788000469 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1225788000470 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1225788000471 elongation factor Tu; Reviewed; Region: PRK00049 1225788000472 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1225788000473 G1 box; other site 1225788000474 GEF interaction site [polypeptide binding]; other site 1225788000475 GTP/Mg2+ binding site [chemical binding]; other site 1225788000476 Switch I region; other site 1225788000477 G2 box; other site 1225788000478 G3 box; other site 1225788000479 Switch II region; other site 1225788000480 G4 box; other site 1225788000481 G5 box; other site 1225788000482 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1225788000483 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1225788000484 Antibiotic Binding Site [chemical binding]; other site 1225788000485 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1225788000486 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1225788000487 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1225788000488 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1225788000489 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1225788000490 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1225788000491 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1225788000492 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1225788000493 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1225788000494 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1225788000495 putative translocon binding site; other site 1225788000496 protein-rRNA interface [nucleotide binding]; other site 1225788000497 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1225788000498 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1225788000499 G-X-X-G motif; other site 1225788000500 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1225788000501 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1225788000502 23S rRNA interface [nucleotide binding]; other site 1225788000503 5S rRNA interface [nucleotide binding]; other site 1225788000504 putative antibiotic binding site [chemical binding]; other site 1225788000505 L25 interface [polypeptide binding]; other site 1225788000506 L27 interface [polypeptide binding]; other site 1225788000507 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1225788000508 23S rRNA interface [nucleotide binding]; other site 1225788000509 putative translocon interaction site; other site 1225788000510 signal recognition particle (SRP54) interaction site; other site 1225788000511 L23 interface [polypeptide binding]; other site 1225788000512 trigger factor interaction site; other site 1225788000513 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1225788000514 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1225788000515 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1225788000516 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1225788000517 RNA binding site [nucleotide binding]; other site 1225788000518 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1225788000519 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1225788000520 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1225788000521 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1225788000522 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1225788000523 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1225788000524 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1225788000525 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1225788000526 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1225788000527 5S rRNA interface [nucleotide binding]; other site 1225788000528 L27 interface [polypeptide binding]; other site 1225788000529 23S rRNA interface [nucleotide binding]; other site 1225788000530 L5 interface [polypeptide binding]; other site 1225788000531 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1225788000532 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1225788000533 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1225788000534 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1225788000535 23S rRNA binding site [nucleotide binding]; other site 1225788000536 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1225788000537 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1225788000538 SecY translocase; Region: SecY; pfam00344 1225788000539 adenylate kinase; Reviewed; Region: adk; PRK00279 1225788000540 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1225788000541 AMP-binding site [chemical binding]; other site 1225788000542 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1225788000543 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1225788000544 active site 1225788000545 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1225788000546 rRNA binding site [nucleotide binding]; other site 1225788000547 predicted 30S ribosome binding site; other site 1225788000548 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1225788000549 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1225788000550 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1225788000551 30S ribosomal protein S11; Validated; Region: PRK05309 1225788000552 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1225788000553 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1225788000554 alphaNTD homodimer interface [polypeptide binding]; other site 1225788000555 alphaNTD - beta interaction site [polypeptide binding]; other site 1225788000556 alphaNTD - beta' interaction site [polypeptide binding]; other site 1225788000557 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1225788000558 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1225788000559 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1225788000560 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1225788000561 Walker A/P-loop; other site 1225788000562 ATP binding site [chemical binding]; other site 1225788000563 Q-loop/lid; other site 1225788000564 ABC transporter signature motif; other site 1225788000565 Walker B; other site 1225788000566 D-loop; other site 1225788000567 H-loop/switch region; other site 1225788000568 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1225788000569 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1225788000570 Walker A/P-loop; other site 1225788000571 ATP binding site [chemical binding]; other site 1225788000572 Q-loop/lid; other site 1225788000573 ABC transporter signature motif; other site 1225788000574 Walker B; other site 1225788000575 D-loop; other site 1225788000576 H-loop/switch region; other site 1225788000577 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1225788000578 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1225788000579 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1225788000580 dimerization interface 3.5A [polypeptide binding]; other site 1225788000581 active site 1225788000582 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1225788000583 23S rRNA interface [nucleotide binding]; other site 1225788000584 L3 interface [polypeptide binding]; other site 1225788000585 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1225788000586 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1225788000587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788000588 S-adenosylmethionine binding site [chemical binding]; other site 1225788000589 DinB family; Region: DinB; cl17821 1225788000590 DinB superfamily; Region: DinB_2; pfam12867 1225788000591 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1225788000592 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1225788000593 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1225788000594 active site 1225788000595 metal binding site [ion binding]; metal-binding site 1225788000596 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1225788000597 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1225788000598 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1225788000599 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1225788000600 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1225788000601 potential RNA of insufficient length (16S ribosomal RNA) 1225788000602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788000603 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788000604 putative substrate translocation pore; other site 1225788000605 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1225788000606 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1225788000607 inhibitor-cofactor binding pocket; inhibition site 1225788000608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788000609 catalytic residue [active] 1225788000610 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1225788000611 active site 1225788000612 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1225788000613 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1225788000614 NAD(P) binding site [chemical binding]; other site 1225788000615 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1225788000616 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1225788000617 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1225788000618 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1225788000619 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1225788000620 Sodium Bile acid symporter family; Region: SBF; cl17470 1225788000621 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1225788000622 Putative esterase; Region: Esterase; pfam00756 1225788000623 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1225788000624 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1225788000625 ABC-ATPase subunit interface; other site 1225788000626 dimer interface [polypeptide binding]; other site 1225788000627 putative PBP binding regions; other site 1225788000628 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1225788000629 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1225788000630 ABC-ATPase subunit interface; other site 1225788000631 dimer interface [polypeptide binding]; other site 1225788000632 putative PBP binding regions; other site 1225788000633 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1225788000634 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1225788000635 intersubunit interface [polypeptide binding]; other site 1225788000636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1225788000637 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1225788000638 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1225788000639 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1225788000640 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1225788000641 intersubunit interface [polypeptide binding]; other site 1225788000642 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 1225788000643 potential frameshift: common BLAST hit: gi|387896689|ref|YP_006326985.1| beta-N-acetylhexosaminidase 1225788000644 putative periplasmic esterase; Provisional; Region: PRK03642 1225788000645 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1225788000646 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1225788000647 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1225788000648 active site turn [active] 1225788000649 phosphorylation site [posttranslational modification] 1225788000650 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1225788000651 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1225788000652 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1225788000653 putative active site [active] 1225788000654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1225788000655 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1225788000656 potential protein location (hypothetical protein B938_00910 [Bacillus amyloliquefaciens subsp. plantarum AS43.3]) that overlaps RNA (tRNA-E) 1225788000657 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1225788000658 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1225788000659 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1225788000660 DNA binding residues [nucleotide binding] 1225788000661 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1225788000662 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1225788000663 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1225788000664 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1225788000665 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1225788000666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1225788000667 YbbR-like protein; Region: YbbR; pfam07949 1225788000668 YbbR-like protein; Region: YbbR; pfam07949 1225788000669 YbbR-like protein; Region: YbbR; pfam07949 1225788000670 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1225788000671 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1225788000672 active site 1225788000673 substrate binding site [chemical binding]; other site 1225788000674 metal binding site [ion binding]; metal-binding site 1225788000675 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1225788000676 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1225788000677 glutaminase active site [active] 1225788000678 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1225788000679 dimer interface [polypeptide binding]; other site 1225788000680 active site 1225788000681 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1225788000682 dimer interface [polypeptide binding]; other site 1225788000683 active site 1225788000684 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1225788000685 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1225788000686 Walker A/P-loop; other site 1225788000687 ATP binding site [chemical binding]; other site 1225788000688 Q-loop/lid; other site 1225788000689 ABC transporter signature motif; other site 1225788000690 Walker B; other site 1225788000691 D-loop; other site 1225788000692 H-loop/switch region; other site 1225788000693 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1225788000694 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1225788000695 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1225788000696 active site 1225788000697 catalytic tetrad [active] 1225788000698 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1225788000699 LrgA family; Region: LrgA; cl00608 1225788000700 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788000701 MarR family; Region: MarR; pfam01047 1225788000702 putative transport protein YifK; Provisional; Region: PRK10746 1225788000703 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1225788000704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788000705 active site 1225788000706 motif I; other site 1225788000707 motif II; other site 1225788000708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1225788000709 Histidine kinase; Region: HisKA_3; pfam07730 1225788000710 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1225788000711 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1225788000712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788000713 active site 1225788000714 phosphorylation site [posttranslational modification] 1225788000715 intermolecular recognition site; other site 1225788000716 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 1225788000717 dimerization interface [polypeptide binding]; other site 1225788000718 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1225788000719 DNA binding residues [nucleotide binding] 1225788000720 dimerization interface [polypeptide binding]; other site 1225788000721 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1225788000722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1225788000723 Walker A/P-loop; other site 1225788000724 ATP binding site [chemical binding]; other site 1225788000725 Q-loop/lid; other site 1225788000726 ABC transporter signature motif; other site 1225788000727 Walker B; other site 1225788000728 D-loop; other site 1225788000729 H-loop/switch region; other site 1225788000730 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1225788000731 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1225788000732 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1225788000733 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1225788000734 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1225788000735 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1225788000736 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1225788000737 active site 1225788000738 catalytic site [active] 1225788000739 metal binding site [ion binding]; metal-binding site 1225788000740 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1225788000741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788000742 putative substrate translocation pore; other site 1225788000743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788000744 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1225788000745 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1225788000746 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1225788000747 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1225788000748 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1225788000749 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1225788000750 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1225788000751 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1225788000752 active site 1225788000753 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788000754 non-specific DNA binding site [nucleotide binding]; other site 1225788000755 salt bridge; other site 1225788000756 sequence-specific DNA binding site [nucleotide binding]; other site 1225788000757 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1225788000758 Glycerol_dehydrogenase-like; Region: GlyDH-like; cd08550 1225788000759 active site 1225788000760 NAD binding site [chemical binding]; other site 1225788000761 metal binding site [ion binding]; metal-binding site 1225788000762 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1225788000763 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1225788000764 ATP-grasp domain; Region: ATP-grasp; pfam02222 1225788000765 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1225788000766 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1225788000767 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1225788000768 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1225788000769 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1225788000770 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1225788000771 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1225788000772 active site residue [active] 1225788000773 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1225788000774 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1225788000775 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1225788000776 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1225788000777 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1225788000778 homodimer interface [polypeptide binding]; other site 1225788000779 substrate-cofactor binding pocket; other site 1225788000780 catalytic residue [active] 1225788000781 S-methylmethionine transporter; Provisional; Region: PRK11387 1225788000782 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1225788000783 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1225788000784 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1225788000785 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1225788000786 glutaminase; Reviewed; Region: PRK12357 1225788000787 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1225788000788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1225788000789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788000790 ATP binding site [chemical binding]; other site 1225788000791 Mg2+ binding site [ion binding]; other site 1225788000792 G-X-G motif; other site 1225788000793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788000794 Response regulator receiver domain; Region: Response_reg; pfam00072 1225788000795 active site 1225788000796 phosphorylation site [posttranslational modification] 1225788000797 intermolecular recognition site; other site 1225788000798 dimerization interface [polypeptide binding]; other site 1225788000799 YcbB domain; Region: YcbB; pfam08664 1225788000800 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1225788000801 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1225788000802 dodecamer interface 1 [polypeptide binding]; other site 1225788000803 dodecamer interface 2 [polypeptide binding]; other site 1225788000804 trimer interface [polypeptide binding]; other site 1225788000805 TRAP binding interface [polypeptide binding]; other site 1225788000806 Zn binding site [ion binding]; other site 1225788000807 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1225788000808 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1225788000809 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1225788000810 dimer interface [polypeptide binding]; other site 1225788000811 FMN binding site [chemical binding]; other site 1225788000812 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1225788000813 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1225788000814 Zn binding site [ion binding]; other site 1225788000815 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1225788000816 Zn binding site [ion binding]; other site 1225788000817 Predicted membrane protein [Function unknown]; Region: COG2259 1225788000818 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1225788000819 catalytic residues [active] 1225788000820 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1225788000821 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1225788000822 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1225788000823 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1225788000824 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1225788000825 putative active site [active] 1225788000826 putative metal binding site [ion binding]; other site 1225788000827 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1225788000828 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1225788000829 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1225788000830 putative substrate binding pocket [chemical binding]; other site 1225788000831 AC domain interface; other site 1225788000832 catalytic triad [active] 1225788000833 AB domain interface; other site 1225788000834 interchain disulfide; other site 1225788000835 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1225788000836 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1225788000837 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1225788000838 catalytic residue [active] 1225788000839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788000840 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1225788000841 putative substrate translocation pore; other site 1225788000842 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788000843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788000844 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1225788000845 active site 1225788000846 homotetramer interface [polypeptide binding]; other site 1225788000847 homodimer interface [polypeptide binding]; other site 1225788000848 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1225788000849 Lipase (class 2); Region: Lipase_2; pfam01674 1225788000850 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1225788000851 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1225788000852 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1225788000853 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1225788000854 active site 1225788000855 catalytic tetrad [active] 1225788000856 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1225788000857 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1225788000858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788000859 binding surface 1225788000860 TPR motif; other site 1225788000861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1225788000862 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788000863 TPR motif; other site 1225788000864 binding surface 1225788000865 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1225788000866 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1225788000867 NAD binding site [chemical binding]; other site 1225788000868 homodimer interface [polypeptide binding]; other site 1225788000869 active site 1225788000870 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1225788000871 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1225788000872 Ca binding site [ion binding]; other site 1225788000873 active site 1225788000874 catalytic site [active] 1225788000875 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1225788000876 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1225788000877 metal binding site [ion binding]; metal-binding site 1225788000878 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1225788000879 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1225788000880 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1225788000881 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1225788000882 ABC-ATPase subunit interface; other site 1225788000883 dimer interface [polypeptide binding]; other site 1225788000884 putative PBP binding regions; other site 1225788000885 potential frameshift: common BLAST hit: gi|387896782|ref|YP_006327078.1| monooxygenase 1225788000886 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1225788000887 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1225788000888 putative metal binding site [ion binding]; other site 1225788000889 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1225788000890 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1225788000891 putative metal binding site [ion binding]; other site 1225788000892 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1225788000893 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1225788000894 putative metal binding site [ion binding]; other site 1225788000895 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1225788000896 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1225788000897 benzoate transport; Region: 2A0115; TIGR00895 1225788000898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788000899 putative substrate translocation pore; other site 1225788000900 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1225788000901 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1225788000902 Walker A/P-loop; other site 1225788000903 ATP binding site [chemical binding]; other site 1225788000904 Q-loop/lid; other site 1225788000905 ABC transporter signature motif; other site 1225788000906 Walker B; other site 1225788000907 D-loop; other site 1225788000908 H-loop/switch region; other site 1225788000909 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1225788000910 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1225788000911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788000912 dimer interface [polypeptide binding]; other site 1225788000913 conserved gate region; other site 1225788000914 putative PBP binding loops; other site 1225788000915 ABC-ATPase subunit interface; other site 1225788000916 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1225788000917 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1225788000918 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1225788000919 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1225788000920 amidohydrolase; Region: amidohydrolases; TIGR01891 1225788000921 metal binding site [ion binding]; metal-binding site 1225788000922 putative dimer interface [polypeptide binding]; other site 1225788000923 Predicted membrane protein [Function unknown]; Region: COG1288 1225788000924 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1225788000925 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 1225788000926 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1225788000927 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1225788000928 active site 1225788000929 Ca binding site [ion binding]; other site 1225788000930 catalytic site [active] 1225788000931 Aamy_C domain; Region: Aamy_C; smart00632 1225788000932 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1225788000933 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1225788000934 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1225788000935 NAD binding site [chemical binding]; other site 1225788000936 dimer interface [polypeptide binding]; other site 1225788000937 substrate binding site [chemical binding]; other site 1225788000938 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1225788000939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788000940 putative substrate translocation pore; other site 1225788000941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788000942 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788000943 MarR family; Region: MarR; pfam01047 1225788000944 LysE type translocator; Region: LysE; pfam01810 1225788000945 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 1225788000946 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1225788000947 Spore germination protein; Region: Spore_permease; cl17796 1225788000948 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1225788000949 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1225788000950 NAD+ synthetase; Region: nadE; TIGR00552 1225788000951 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1225788000952 homodimer interface [polypeptide binding]; other site 1225788000953 NAD binding pocket [chemical binding]; other site 1225788000954 ATP binding pocket [chemical binding]; other site 1225788000955 Mg binding site [ion binding]; other site 1225788000956 active-site loop [active] 1225788000957 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 1225788000958 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1225788000959 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1225788000960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788000961 D-galactonate transporter; Region: 2A0114; TIGR00893 1225788000962 putative substrate translocation pore; other site 1225788000963 shikimate kinase; Reviewed; Region: aroK; PRK00131 1225788000964 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1225788000965 ADP binding site [chemical binding]; other site 1225788000966 magnesium binding site [ion binding]; other site 1225788000967 putative shikimate binding site; other site 1225788000968 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1225788000969 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1225788000970 Proline dehydrogenase; Region: Pro_dh; pfam01619 1225788000971 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1225788000972 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1225788000973 Glutamate binding site [chemical binding]; other site 1225788000974 homodimer interface [polypeptide binding]; other site 1225788000975 NAD binding site [chemical binding]; other site 1225788000976 catalytic residues [active] 1225788000977 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1225788000978 Na binding site [ion binding]; other site 1225788000979 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1225788000980 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1225788000981 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1225788000982 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1225788000983 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1225788000984 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 1225788000985 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1225788000986 active site 1225788000987 SAM binding site [chemical binding]; other site 1225788000988 homodimer interface [polypeptide binding]; other site 1225788000989 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1225788000990 [2Fe-2S] cluster binding site [ion binding]; other site 1225788000991 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1225788000992 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1225788000993 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1225788000994 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1225788000995 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1225788000996 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1225788000997 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1225788000998 [4Fe-4S] binding site [ion binding]; other site 1225788000999 molybdopterin cofactor binding site; other site 1225788001000 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1225788001001 molybdopterin cofactor binding site; other site 1225788001002 potential frameshift: common BLAST hit: gi|154684822|ref|YP_001419983.1| NasB 1225788001003 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1225788001004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788001005 putative substrate translocation pore; other site 1225788001006 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1225788001007 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1225788001008 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1225788001009 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1225788001010 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1225788001011 NAD binding site [chemical binding]; other site 1225788001012 catalytic Zn binding site [ion binding]; other site 1225788001013 structural Zn binding site [ion binding]; other site 1225788001014 RDD family; Region: RDD; pfam06271 1225788001015 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1225788001016 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1225788001017 beta-galactosidase; Region: BGL; TIGR03356 1225788001018 Competence protein J (ComJ); Region: ComJ; pfam11033 1225788001019 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1225788001020 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1225788001021 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1225788001022 tetramer interface [polypeptide binding]; other site 1225788001023 active site 1225788001024 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1225788001025 active site 1225788001026 dimer interface [polypeptide binding]; other site 1225788001027 magnesium binding site [ion binding]; other site 1225788001028 Predicted transcriptional regulators [Transcription]; Region: COG1733 1225788001029 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1225788001030 Condensation domain; Region: Condensation; pfam00668 1225788001031 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788001032 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788001033 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788001034 acyl-activating enzyme (AAE) consensus motif; other site 1225788001035 AMP binding site [chemical binding]; other site 1225788001036 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788001037 Condensation domain; Region: Condensation; pfam00668 1225788001038 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788001039 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788001040 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1225788001041 acyl-activating enzyme (AAE) consensus motif; other site 1225788001042 AMP binding site [chemical binding]; other site 1225788001043 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788001044 Condensation domain; Region: Condensation; pfam00668 1225788001045 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788001046 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788001047 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788001048 acyl-activating enzyme (AAE) consensus motif; other site 1225788001049 AMP binding site [chemical binding]; other site 1225788001050 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788001051 Condensation domain; Region: Condensation; pfam00668 1225788001052 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1225788001053 Condensation domain; Region: Condensation; pfam00668 1225788001054 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788001055 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1225788001056 acyl-activating enzyme (AAE) consensus motif; other site 1225788001057 AMP binding site [chemical binding]; other site 1225788001058 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788001059 Condensation domain; Region: Condensation; pfam00668 1225788001060 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788001061 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788001062 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788001063 acyl-activating enzyme (AAE) consensus motif; other site 1225788001064 AMP binding site [chemical binding]; other site 1225788001065 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788001066 Condensation domain; Region: Condensation; pfam00668 1225788001067 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788001068 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788001069 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788001070 acyl-activating enzyme (AAE) consensus motif; other site 1225788001071 AMP binding site [chemical binding]; other site 1225788001072 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788001073 Condensation domain; Region: Condensation; pfam00668 1225788001074 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788001075 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1225788001076 Condensation domain; Region: Condensation; pfam00668 1225788001077 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788001078 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1225788001079 acyl-activating enzyme (AAE) consensus motif; other site 1225788001080 AMP binding site [chemical binding]; other site 1225788001081 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788001082 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1225788001083 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1225788001084 PGAP1-like protein; Region: PGAP1; pfam07819 1225788001085 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1225788001086 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1225788001087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788001088 homodimer interface [polypeptide binding]; other site 1225788001089 catalytic residue [active] 1225788001090 YcxB-like protein; Region: YcxB; pfam14317 1225788001091 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1225788001092 EamA-like transporter family; Region: EamA; pfam00892 1225788001093 EamA-like transporter family; Region: EamA; pfam00892 1225788001094 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1225788001095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788001096 DNA-binding site [nucleotide binding]; DNA binding site 1225788001097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1225788001098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788001099 homodimer interface [polypeptide binding]; other site 1225788001100 catalytic residue [active] 1225788001101 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1225788001102 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 1225788001103 Predicted membrane protein [Function unknown]; Region: COG2364 1225788001104 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1225788001105 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1225788001106 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1225788001107 Walker A/P-loop; other site 1225788001108 ATP binding site [chemical binding]; other site 1225788001109 Q-loop/lid; other site 1225788001110 ABC transporter signature motif; other site 1225788001111 Walker B; other site 1225788001112 D-loop; other site 1225788001113 H-loop/switch region; other site 1225788001114 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1225788001115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788001116 dimer interface [polypeptide binding]; other site 1225788001117 conserved gate region; other site 1225788001118 putative PBP binding loops; other site 1225788001119 ABC-ATPase subunit interface; other site 1225788001120 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1225788001121 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1225788001122 substrate binding pocket [chemical binding]; other site 1225788001123 membrane-bound complex binding site; other site 1225788001124 hinge residues; other site 1225788001125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788001126 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788001127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1225788001128 dimerization interface [polypeptide binding]; other site 1225788001129 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1225788001130 Flavoprotein; Region: Flavoprotein; pfam02441 1225788001131 UbiD family decarboxylase; Region: TIGR00148 1225788001132 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1225788001133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788001134 putative substrate translocation pore; other site 1225788001135 POT family; Region: PTR2; pfam00854 1225788001136 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1225788001137 Right handed beta helix region; Region: Beta_helix; pfam13229 1225788001138 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1225788001139 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1225788001140 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1225788001141 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1225788001142 Spore germination protein; Region: Spore_permease; pfam03845 1225788001143 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1225788001144 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1225788001145 active site 1225788001146 non-prolyl cis peptide bond; other site 1225788001147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788001148 Coenzyme A binding pocket [chemical binding]; other site 1225788001149 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1225788001150 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1225788001151 substrate binding pocket [chemical binding]; other site 1225788001152 membrane-bound complex binding site; other site 1225788001153 hinge residues; other site 1225788001154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788001155 dimer interface [polypeptide binding]; other site 1225788001156 conserved gate region; other site 1225788001157 putative PBP binding loops; other site 1225788001158 ABC-ATPase subunit interface; other site 1225788001159 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1225788001160 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1225788001161 Walker A/P-loop; other site 1225788001162 ATP binding site [chemical binding]; other site 1225788001163 Q-loop/lid; other site 1225788001164 ABC transporter signature motif; other site 1225788001165 Walker B; other site 1225788001166 D-loop; other site 1225788001167 H-loop/switch region; other site 1225788001168 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1225788001169 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1225788001170 metal binding site [ion binding]; metal-binding site 1225788001171 dimer interface [polypeptide binding]; other site 1225788001172 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1225788001173 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1225788001174 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1225788001175 Walker A/P-loop; other site 1225788001176 ATP binding site [chemical binding]; other site 1225788001177 Q-loop/lid; other site 1225788001178 ABC transporter signature motif; other site 1225788001179 Walker B; other site 1225788001180 D-loop; other site 1225788001181 H-loop/switch region; other site 1225788001182 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1225788001183 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1225788001184 FtsX-like permease family; Region: FtsX; pfam02687 1225788001185 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1225788001186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788001187 active site 1225788001188 phosphorylation site [posttranslational modification] 1225788001189 intermolecular recognition site; other site 1225788001190 dimerization interface [polypeptide binding]; other site 1225788001191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1225788001192 DNA binding site [nucleotide binding] 1225788001193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1225788001194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1225788001195 dimerization interface [polypeptide binding]; other site 1225788001196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788001197 dimer interface [polypeptide binding]; other site 1225788001198 phosphorylation site [posttranslational modification] 1225788001199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788001200 ATP binding site [chemical binding]; other site 1225788001201 Mg2+ binding site [ion binding]; other site 1225788001202 G-X-G motif; other site 1225788001203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1225788001204 binding surface 1225788001205 TPR motif; other site 1225788001206 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788001207 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788001208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788001209 TPR motif; other site 1225788001210 binding surface 1225788001211 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788001212 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1225788001213 aspartate kinase; Reviewed; Region: PRK09034 1225788001214 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1225788001215 putative catalytic residues [active] 1225788001216 putative nucleotide binding site [chemical binding]; other site 1225788001217 putative aspartate binding site [chemical binding]; other site 1225788001218 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1225788001219 allosteric regulatory residue; other site 1225788001220 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1225788001221 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1225788001222 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1225788001223 ABC-ATPase subunit interface; other site 1225788001224 dimer interface [polypeptide binding]; other site 1225788001225 putative PBP binding regions; other site 1225788001226 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1225788001227 ABC-ATPase subunit interface; other site 1225788001228 dimer interface [polypeptide binding]; other site 1225788001229 putative PBP binding regions; other site 1225788001230 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1225788001231 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1225788001232 Walker A/P-loop; other site 1225788001233 ATP binding site [chemical binding]; other site 1225788001234 Q-loop/lid; other site 1225788001235 ABC transporter signature motif; other site 1225788001236 Walker B; other site 1225788001237 D-loop; other site 1225788001238 H-loop/switch region; other site 1225788001239 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1225788001240 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1225788001241 putative ligand binding residues [chemical binding]; other site 1225788001242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788001243 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788001244 putative substrate translocation pore; other site 1225788001245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788001246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788001247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788001248 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1225788001249 dimer interface [polypeptide binding]; other site 1225788001250 FMN binding site [chemical binding]; other site 1225788001251 NADPH bind site [chemical binding]; other site 1225788001252 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1225788001253 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1225788001254 dimerization interface [polypeptide binding]; other site 1225788001255 putative DNA binding site [nucleotide binding]; other site 1225788001256 putative Zn2+ binding site [ion binding]; other site 1225788001257 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1225788001258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788001259 DNA-binding site [nucleotide binding]; DNA binding site 1225788001260 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1225788001261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788001262 homodimer interface [polypeptide binding]; other site 1225788001263 catalytic residue [active] 1225788001264 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1225788001265 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1225788001266 inhibitor-cofactor binding pocket; inhibition site 1225788001267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788001268 catalytic residue [active] 1225788001269 succinic semialdehyde dehydrogenase; Region: PLN02278 1225788001270 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1225788001271 tetramerization interface [polypeptide binding]; other site 1225788001272 NAD(P) binding site [chemical binding]; other site 1225788001273 catalytic residues [active] 1225788001274 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1225788001275 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1225788001276 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1225788001277 NAD binding site [chemical binding]; other site 1225788001278 homodimer interface [polypeptide binding]; other site 1225788001279 active site 1225788001280 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1225788001281 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1225788001282 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1225788001283 YtkA-like; Region: YtkA; pfam13115 1225788001284 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1225788001285 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1225788001286 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1225788001287 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1225788001288 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1225788001289 active site 1225788001290 P-loop; other site 1225788001291 phosphorylation site [posttranslational modification] 1225788001292 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1225788001293 active site 1225788001294 phosphorylation site [posttranslational modification] 1225788001295 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1225788001296 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1225788001297 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1225788001298 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1225788001299 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1225788001300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788001301 active site 1225788001302 motif I; other site 1225788001303 motif II; other site 1225788001304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788001305 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1225788001306 putative active site [active] 1225788001307 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1225788001308 hypothetical protein; Provisional; Region: PRK05463 1225788001309 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1225788001310 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1225788001311 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1225788001312 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1225788001313 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1225788001314 Bacterial transcriptional regulator; Region: IclR; pfam01614 1225788001315 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1225788001316 active site 1225788001317 catalytic triad [active] 1225788001318 oxyanion hole [active] 1225788001319 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1225788001320 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1225788001321 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1225788001322 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1225788001323 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1225788001324 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1225788001325 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1225788001326 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1225788001327 active site 1225788001328 catalytic tetrad [active] 1225788001329 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1225788001330 HTH domain; Region: HTH_11; pfam08279 1225788001331 Mga helix-turn-helix domain; Region: Mga; pfam05043 1225788001332 PRD domain; Region: PRD; pfam00874 1225788001333 PRD domain; Region: PRD; pfam00874 1225788001334 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1225788001335 active site 1225788001336 P-loop; other site 1225788001337 phosphorylation site [posttranslational modification] 1225788001338 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1225788001339 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1225788001340 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1225788001341 acyl-activating enzyme (AAE) consensus motif; other site 1225788001342 putative AMP binding site [chemical binding]; other site 1225788001343 putative active site [active] 1225788001344 putative CoA binding site [chemical binding]; other site 1225788001345 short chain dehydrogenase; Provisional; Region: PRK06701 1225788001346 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1225788001347 NAD binding site [chemical binding]; other site 1225788001348 metal binding site [ion binding]; metal-binding site 1225788001349 active site 1225788001350 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1225788001351 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1225788001352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1225788001353 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1225788001354 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1225788001355 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1225788001356 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1225788001357 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1225788001358 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1225788001359 putative DNA binding site [nucleotide binding]; other site 1225788001360 putative Zn2+ binding site [ion binding]; other site 1225788001361 AsnC family; Region: AsnC_trans_reg; pfam01037 1225788001362 DNA topoisomerase III; Provisional; Region: PRK07726 1225788001363 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1225788001364 active site 1225788001365 putative interdomain interaction site [polypeptide binding]; other site 1225788001366 putative metal-binding site [ion binding]; other site 1225788001367 putative nucleotide binding site [chemical binding]; other site 1225788001368 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1225788001369 domain I; other site 1225788001370 DNA binding groove [nucleotide binding] 1225788001371 phosphate binding site [ion binding]; other site 1225788001372 domain II; other site 1225788001373 domain III; other site 1225788001374 nucleotide binding site [chemical binding]; other site 1225788001375 catalytic site [active] 1225788001376 domain IV; other site 1225788001377 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1225788001378 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1225788001379 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1225788001380 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1225788001381 metal binding site [ion binding]; metal-binding site 1225788001382 active site 1225788001383 I-site; other site 1225788001384 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1225788001385 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1225788001386 NodB motif; other site 1225788001387 putative active site [active] 1225788001388 putative catalytic site [active] 1225788001389 putative Zn binding site [ion binding]; other site 1225788001390 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1225788001391 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1225788001392 DXD motif; other site 1225788001393 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1225788001394 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1225788001395 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1225788001396 nudix motif; other site 1225788001397 pyruvate oxidase; Provisional; Region: PRK08611 1225788001398 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1225788001399 PYR/PP interface [polypeptide binding]; other site 1225788001400 dimer interface [polypeptide binding]; other site 1225788001401 tetramer interface [polypeptide binding]; other site 1225788001402 TPP binding site [chemical binding]; other site 1225788001403 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1225788001404 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1225788001405 TPP-binding site [chemical binding]; other site 1225788001406 manganese transport protein MntH; Reviewed; Region: PRK00701 1225788001407 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1225788001408 Bacterial SH3 domain; Region: SH3_3; cl17532 1225788001409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1225788001410 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1225788001411 EcsC protein family; Region: EcsC; pfam12787 1225788001412 General stress protein [General function prediction only]; Region: GsiB; COG3729 1225788001413 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1225788001414 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1225788001415 dimanganese center [ion binding]; other site 1225788001416 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1225788001417 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1225788001418 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1225788001419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1225788001420 putative active site [active] 1225788001421 heme pocket [chemical binding]; other site 1225788001422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788001423 ATP binding site [chemical binding]; other site 1225788001424 Mg2+ binding site [ion binding]; other site 1225788001425 G-X-G motif; other site 1225788001426 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1225788001427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788001428 active site 1225788001429 phosphorylation site [posttranslational modification] 1225788001430 intermolecular recognition site; other site 1225788001431 dimerization interface [polypeptide binding]; other site 1225788001432 HTH domain; Region: HTH_11; pfam08279 1225788001433 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1225788001434 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1225788001435 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1225788001436 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1225788001437 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1225788001438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1225788001439 Walker A/P-loop; other site 1225788001440 ATP binding site [chemical binding]; other site 1225788001441 Q-loop/lid; other site 1225788001442 ABC transporter signature motif; other site 1225788001443 Walker B; other site 1225788001444 D-loop; other site 1225788001445 H-loop/switch region; other site 1225788001446 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1225788001447 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1225788001448 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1225788001449 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1225788001450 active site 1225788001451 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1225788001452 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1225788001453 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1225788001454 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1225788001455 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1225788001456 catalytic residues [active] 1225788001457 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1225788001458 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1225788001459 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1225788001460 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1225788001461 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1225788001462 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1225788001463 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1225788001464 helicase 45; Provisional; Region: PTZ00424 1225788001465 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1225788001466 ATP binding site [chemical binding]; other site 1225788001467 Mg++ binding site [ion binding]; other site 1225788001468 motif III; other site 1225788001469 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1225788001470 nucleotide binding region [chemical binding]; other site 1225788001471 ATP-binding site [chemical binding]; other site 1225788001472 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1225788001473 Predicted membrane protein [Function unknown]; Region: COG3428 1225788001474 Bacterial PH domain; Region: DUF304; pfam03703 1225788001475 Bacterial PH domain; Region: DUF304; pfam03703 1225788001476 Bacterial PH domain; Region: DUF304; pfam03703 1225788001477 Rhomboid family; Region: Rhomboid; pfam01694 1225788001478 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1225788001479 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1225788001480 alanine racemase; Region: alr; TIGR00492 1225788001481 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1225788001482 active site 1225788001483 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1225788001484 dimer interface [polypeptide binding]; other site 1225788001485 substrate binding site [chemical binding]; other site 1225788001486 catalytic residues [active] 1225788001487 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1225788001488 ribbon-helix-helix domain containing protein; Region: PHA00617 1225788001489 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1225788001490 Rsbr N terminal; Region: Rsbr_N; pfam08678 1225788001491 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1225788001492 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1225788001493 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1225788001494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788001495 ATP binding site [chemical binding]; other site 1225788001496 Mg2+ binding site [ion binding]; other site 1225788001497 G-X-G motif; other site 1225788001498 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1225788001499 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1225788001500 CoA binding domain; Region: CoA_binding; cl17356 1225788001501 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1225788001502 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1225788001503 anti sigma factor interaction site; other site 1225788001504 regulatory phosphorylation site [posttranslational modification]; other site 1225788001505 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1225788001506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788001507 ATP binding site [chemical binding]; other site 1225788001508 Mg2+ binding site [ion binding]; other site 1225788001509 G-X-G motif; other site 1225788001510 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1225788001511 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1225788001512 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1225788001513 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1225788001514 DNA binding residues [nucleotide binding] 1225788001515 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1225788001516 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1225788001517 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1225788001518 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1225788001519 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1225788001520 RNA binding site [nucleotide binding]; other site 1225788001521 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1225788001522 hypothetical protein; Provisional; Region: PRK04351 1225788001523 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1225788001524 Int/Topo IB signature motif; other site 1225788001525 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 1225788001526 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 1225788001527 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1225788001528 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1225788001529 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 1225788001530 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1225788001531 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1225788001532 dimerization interface [polypeptide binding]; other site 1225788001533 putative DNA binding site [nucleotide binding]; other site 1225788001534 putative Zn2+ binding site [ion binding]; other site 1225788001535 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1225788001536 active site residue [active] 1225788001537 DsrE/DsrF-like family; Region: DrsE; cl00672 1225788001538 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788001539 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1225788001540 BCCT family transporter; Region: BCCT; cl00569 1225788001541 proline/glycine betaine transporter; Provisional; Region: PRK10642 1225788001542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788001543 putative substrate translocation pore; other site 1225788001544 MarR family; Region: MarR_2; cl17246 1225788001545 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1225788001546 putative active site [active] 1225788001547 putative catalytic site [active] 1225788001548 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1225788001549 Predicted transcriptional regulator [Transcription]; Region: COG1959 1225788001550 Transcriptional regulator; Region: Rrf2; pfam02082 1225788001551 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1225788001552 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1225788001553 NAD binding site [chemical binding]; other site 1225788001554 substrate binding site [chemical binding]; other site 1225788001555 putative active site [active] 1225788001556 SEFIR domain; Region: SEFIR; pfam08357 1225788001557 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1225788001558 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1225788001559 putative NAD(P) binding site [chemical binding]; other site 1225788001560 Predicted transcriptional regulators [Transcription]; Region: COG1733 1225788001561 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1225788001562 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1225788001563 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1225788001564 putative di-iron ligands [ion binding]; other site 1225788001565 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1225788001566 DNA-binding site [nucleotide binding]; DNA binding site 1225788001567 RNA-binding motif; other site 1225788001568 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1225788001569 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1225788001570 putative homodimer interface [polypeptide binding]; other site 1225788001571 putative homotetramer interface [polypeptide binding]; other site 1225788001572 putative metal binding site [ion binding]; other site 1225788001573 putative homodimer-homodimer interface [polypeptide binding]; other site 1225788001574 putative allosteric switch controlling residues; other site 1225788001575 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1225788001576 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1225788001577 CPxP motif; other site 1225788001578 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1225788001579 active site residue [active] 1225788001580 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1225788001581 active site residue [active] 1225788001582 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1225788001583 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1225788001584 CPxP motif; other site 1225788001585 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1225788001586 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1225788001587 aspartate racemase; Region: asp_race; TIGR00035 1225788001588 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1225788001589 Predicted transcriptional regulators [Transcription]; Region: COG1695 1225788001590 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1225788001591 Patatin [General function prediction only]; Region: COG3621 1225788001592 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 1225788001593 active site 1225788001594 nucleophile elbow; other site 1225788001595 DinB family; Region: DinB; cl17821 1225788001596 DinB superfamily; Region: DinB_2; pfam12867 1225788001597 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1225788001598 FAD binding domain; Region: FAD_binding_4; pfam01565 1225788001599 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1225788001600 Berberine and berberine like; Region: BBE; pfam08031 1225788001601 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1225788001602 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1225788001603 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1225788001604 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1225788001605 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1225788001606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1225788001607 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1225788001608 DinB superfamily; Region: DinB_2; pfam12867 1225788001609 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1225788001610 N-acetylneuraminate lyase; Region: nanA; TIGR00683 1225788001611 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1225788001612 inhibitor site; inhibition site 1225788001613 active site 1225788001614 dimer interface [polypeptide binding]; other site 1225788001615 catalytic residue [active] 1225788001616 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 1225788001617 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1225788001618 FeS/SAM binding site; other site 1225788001619 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1225788001620 Sodium Bile acid symporter family; Region: SBF; cl17470 1225788001621 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1225788001622 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1225788001623 putative NAD(P) binding site [chemical binding]; other site 1225788001624 putative substrate binding site [chemical binding]; other site 1225788001625 catalytic Zn binding site [ion binding]; other site 1225788001626 structural Zn binding site [ion binding]; other site 1225788001627 dimer interface [polypeptide binding]; other site 1225788001628 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1225788001629 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1225788001630 DNA binding residues [nucleotide binding] 1225788001631 putative dimer interface [polypeptide binding]; other site 1225788001632 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1225788001633 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1225788001634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788001635 DNA-binding site [nucleotide binding]; DNA binding site 1225788001636 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1225788001637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788001638 homodimer interface [polypeptide binding]; other site 1225788001639 catalytic residue [active] 1225788001640 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1225788001641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1225788001642 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1225788001643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788001644 active site 1225788001645 phosphorylation site [posttranslational modification] 1225788001646 intermolecular recognition site; other site 1225788001647 dimerization interface [polypeptide binding]; other site 1225788001648 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1225788001649 DNA binding site [nucleotide binding] 1225788001650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1225788001651 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1225788001652 dimerization interface [polypeptide binding]; other site 1225788001653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788001654 dimer interface [polypeptide binding]; other site 1225788001655 phosphorylation site [posttranslational modification] 1225788001656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788001657 ATP binding site [chemical binding]; other site 1225788001658 Mg2+ binding site [ion binding]; other site 1225788001659 G-X-G motif; other site 1225788001660 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1225788001661 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1225788001662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788001663 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788001664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788001665 potential frameshift: common BLAST hit: gi|384264132|ref|YP_005419839.1| putative transporter 1225788001666 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1225788001667 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788001668 DNA-binding site [nucleotide binding]; DNA binding site 1225788001669 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1225788001670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788001671 homodimer interface [polypeptide binding]; other site 1225788001672 catalytic residue [active] 1225788001673 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1225788001674 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1225788001675 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1225788001676 NAD binding site [chemical binding]; other site 1225788001677 catalytic Zn binding site [ion binding]; other site 1225788001678 structural Zn binding site [ion binding]; other site 1225788001679 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1225788001680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1225788001681 Histidine kinase; Region: HisKA_3; pfam07730 1225788001682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788001683 ATP binding site [chemical binding]; other site 1225788001684 Mg2+ binding site [ion binding]; other site 1225788001685 G-X-G motif; other site 1225788001686 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1225788001687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788001688 active site 1225788001689 phosphorylation site [posttranslational modification] 1225788001690 intermolecular recognition site; other site 1225788001691 dimerization interface [polypeptide binding]; other site 1225788001692 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1225788001693 DNA binding residues [nucleotide binding] 1225788001694 dimerization interface [polypeptide binding]; other site 1225788001695 MMPL family; Region: MMPL; pfam03176 1225788001696 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 1225788001697 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1225788001698 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1225788001699 catalytic triad [active] 1225788001700 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1225788001701 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1225788001702 ABC transporter; Region: ABC_tran_2; pfam12848 1225788001703 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1225788001704 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1225788001705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788001706 Coenzyme A binding pocket [chemical binding]; other site 1225788001707 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1225788001708 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1225788001709 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1225788001710 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1225788001711 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1225788001712 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1225788001713 dimer interface [polypeptide binding]; other site 1225788001714 active site 1225788001715 metal binding site [ion binding]; metal-binding site 1225788001716 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1225788001717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788001718 putative substrate translocation pore; other site 1225788001719 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1225788001720 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1225788001721 dimer interface [polypeptide binding]; other site 1225788001722 active site 1225788001723 Helix-turn-helix domain; Region: HTH_31; pfam13560 1225788001724 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1225788001725 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1225788001726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788001727 Coenzyme A binding pocket [chemical binding]; other site 1225788001728 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1225788001729 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1225788001730 DNA binding residues [nucleotide binding] 1225788001731 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1225788001732 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1225788001733 EamA-like transporter family; Region: EamA; pfam00892 1225788001734 EamA-like transporter family; Region: EamA; pfam00892 1225788001735 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1225788001736 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1225788001737 nudix motif; other site 1225788001738 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1225788001739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788001740 S-adenosylmethionine binding site [chemical binding]; other site 1225788001741 tartrate dehydrogenase; Provisional; Region: PRK08194 1225788001742 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1225788001743 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1225788001744 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788001745 DNA-binding site [nucleotide binding]; DNA binding site 1225788001746 FCD domain; Region: FCD; pfam07729 1225788001747 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1225788001748 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1225788001749 active site 1225788001750 TDP-binding site; other site 1225788001751 acceptor substrate-binding pocket; other site 1225788001752 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1225788001753 Beta-lactamase; Region: Beta-lactamase; pfam00144 1225788001754 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1225788001755 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1225788001756 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1225788001757 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1225788001758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788001759 putative substrate translocation pore; other site 1225788001760 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1225788001761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788001762 DNA-binding site [nucleotide binding]; DNA binding site 1225788001763 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1225788001764 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1225788001765 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788001766 DNA-binding site [nucleotide binding]; DNA binding site 1225788001767 FCD domain; Region: FCD; pfam07729 1225788001768 'potential frameshift: common BLAST hit: gi|387897092|ref|YP_006327388.1| MFS transporter, CP family, cyanate transporter' 1225788001769 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1225788001770 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1225788001771 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788001772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788001773 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1225788001774 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1225788001775 dimanganese center [ion binding]; other site 1225788001776 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1225788001777 putative hydrophobic ligand binding site [chemical binding]; other site 1225788001778 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1225788001779 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1225788001780 putative NADP binding site [chemical binding]; other site 1225788001781 putative dimer interface [polypeptide binding]; other site 1225788001782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788001783 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1225788001784 putative substrate translocation pore; other site 1225788001785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788001786 thiamine monophosphate kinase; Provisional; Region: PRK05731 1225788001787 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1225788001788 ATP binding site [chemical binding]; other site 1225788001789 dimerization interface [polypeptide binding]; other site 1225788001790 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1225788001791 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1225788001792 Glycoprotease family; Region: Peptidase_M22; pfam00814 1225788001793 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1225788001794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788001795 Coenzyme A binding pocket [chemical binding]; other site 1225788001796 UGMP family protein; Validated; Region: PRK09604 1225788001797 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1225788001798 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1225788001799 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1225788001800 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1225788001801 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1225788001802 ABC transporter; Region: ABC_tran_2; pfam12848 1225788001803 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1225788001804 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1225788001805 trimer interface [polypeptide binding]; other site 1225788001806 dimer interface [polypeptide binding]; other site 1225788001807 putative active site [active] 1225788001808 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1225788001809 CoA binding domain; Region: CoA_binding; pfam02629 1225788001810 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1225788001811 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1225788001812 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1225788001813 CAAX protease self-immunity; Region: Abi; pfam02517 1225788001814 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1225788001815 oligomerisation interface [polypeptide binding]; other site 1225788001816 mobile loop; other site 1225788001817 roof hairpin; other site 1225788001818 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1225788001819 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1225788001820 ring oligomerisation interface [polypeptide binding]; other site 1225788001821 ATP/Mg binding site [chemical binding]; other site 1225788001822 stacking interactions; other site 1225788001823 hinge regions; other site 1225788001824 AAA ATPase domain; Region: AAA_16; pfam13191 1225788001825 AAA domain; Region: AAA_22; pfam13401 1225788001826 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788001827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788001828 binding surface 1225788001829 TPR motif; other site 1225788001830 TPR repeat; Region: TPR_11; pfam13414 1225788001831 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1225788001832 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1225788001833 inhibitor binding site; inhibition site 1225788001834 catalytic Zn binding site [ion binding]; other site 1225788001835 structural Zn binding site [ion binding]; other site 1225788001836 NADP binding site [chemical binding]; other site 1225788001837 tetramer interface [polypeptide binding]; other site 1225788001838 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1225788001839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788001840 putative substrate translocation pore; other site 1225788001841 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1225788001842 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1225788001843 putative substrate binding site [chemical binding]; other site 1225788001844 putative ATP binding site [chemical binding]; other site 1225788001845 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1225788001846 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1225788001847 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 1225788001848 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1225788001849 Repair protein; Region: Repair_PSII; pfam04536 1225788001850 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1225788001851 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1225788001852 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1225788001853 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1225788001854 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1225788001855 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1225788001856 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1225788001857 catalytic triad [active] 1225788001858 catalytic triad [active] 1225788001859 oxyanion hole [active] 1225788001860 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1225788001861 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1225788001862 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1225788001863 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1225788001864 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1225788001865 DNA binding residues [nucleotide binding] 1225788001866 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1225788001867 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1225788001868 putative NAD(P) binding site [chemical binding]; other site 1225788001869 catalytic Zn binding site [ion binding]; other site 1225788001870 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1225788001871 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1225788001872 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1225788001873 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1225788001874 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1225788001875 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1225788001876 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1225788001877 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1225788001878 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1225788001879 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1225788001880 MoxR-like ATPases [General function prediction only]; Region: COG0714 1225788001881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788001882 Walker A motif; other site 1225788001883 ATP binding site [chemical binding]; other site 1225788001884 Walker B motif; other site 1225788001885 arginine finger; other site 1225788001886 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1225788001887 Protein of unknown function DUF58; Region: DUF58; pfam01882 1225788001888 potential frameshift: common BLAST hit: gi|384264216|ref|YP_005419923.1| membrane-bound protease 1225788001889 GMP synthase; Reviewed; Region: guaA; PRK00074 1225788001890 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1225788001891 AMP/PPi binding site [chemical binding]; other site 1225788001892 candidate oxyanion hole; other site 1225788001893 catalytic triad [active] 1225788001894 potential glutamine specificity residues [chemical binding]; other site 1225788001895 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1225788001896 ATP Binding subdomain [chemical binding]; other site 1225788001897 Ligand Binding sites [chemical binding]; other site 1225788001898 Dimerization subdomain; other site 1225788001899 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1225788001900 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1225788001901 putative active site [active] 1225788001902 putative NTP binding site [chemical binding]; other site 1225788001903 putative nucleic acid binding site [nucleotide binding]; other site 1225788001904 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1225788001905 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1225788001906 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1225788001907 DNA binding residues [nucleotide binding] 1225788001908 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1225788001909 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1225788001910 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1225788001911 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1225788001912 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1225788001913 NETI protein; Region: NETI; pfam14044 1225788001914 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1225788001915 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1225788001916 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1225788001917 NAD binding site [chemical binding]; other site 1225788001918 ATP-grasp domain; Region: ATP-grasp; pfam02222 1225788001919 adenylosuccinate lyase; Provisional; Region: PRK07492 1225788001920 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1225788001921 tetramer interface [polypeptide binding]; other site 1225788001922 active site 1225788001923 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1225788001924 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1225788001925 ATP binding site [chemical binding]; other site 1225788001926 active site 1225788001927 substrate binding site [chemical binding]; other site 1225788001928 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1225788001929 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1225788001930 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1225788001931 putative active site [active] 1225788001932 catalytic triad [active] 1225788001933 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1225788001934 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1225788001935 dimerization interface [polypeptide binding]; other site 1225788001936 ATP binding site [chemical binding]; other site 1225788001937 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1225788001938 dimerization interface [polypeptide binding]; other site 1225788001939 ATP binding site [chemical binding]; other site 1225788001940 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1225788001941 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1225788001942 active site 1225788001943 tetramer interface [polypeptide binding]; other site 1225788001944 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1225788001945 active site 1225788001946 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1225788001947 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1225788001948 dimerization interface [polypeptide binding]; other site 1225788001949 putative ATP binding site [chemical binding]; other site 1225788001950 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1225788001951 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1225788001952 active site 1225788001953 substrate binding site [chemical binding]; other site 1225788001954 cosubstrate binding site; other site 1225788001955 catalytic site [active] 1225788001956 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1225788001957 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1225788001958 purine monophosphate binding site [chemical binding]; other site 1225788001959 dimer interface [polypeptide binding]; other site 1225788001960 putative catalytic residues [active] 1225788001961 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1225788001962 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1225788001963 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1225788001964 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1225788001965 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1225788001966 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1225788001967 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1225788001968 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1225788001969 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1225788001970 active site 1225788001971 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1225788001972 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1225788001973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1225788001974 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1225788001975 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1225788001976 active site 1225788001977 FMN binding site [chemical binding]; other site 1225788001978 substrate binding site [chemical binding]; other site 1225788001979 3Fe-4S cluster binding site [ion binding]; other site 1225788001980 PcrB family; Region: PcrB; pfam01884 1225788001981 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1225788001982 substrate binding site [chemical binding]; other site 1225788001983 putative active site [active] 1225788001984 dimer interface [polypeptide binding]; other site 1225788001985 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1225788001986 Part of AAA domain; Region: AAA_19; pfam13245 1225788001987 Family description; Region: UvrD_C_2; pfam13538 1225788001988 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1225788001989 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1225788001990 nucleotide binding pocket [chemical binding]; other site 1225788001991 K-X-D-G motif; other site 1225788001992 catalytic site [active] 1225788001993 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1225788001994 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1225788001995 Helix-hairpin-helix motif; Region: HHH; pfam00633 1225788001996 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1225788001997 Dimer interface [polypeptide binding]; other site 1225788001998 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1225788001999 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1225788002000 putative dimer interface [polypeptide binding]; other site 1225788002001 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1225788002002 putative dimer interface [polypeptide binding]; other site 1225788002003 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1225788002004 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1225788002005 active site 1225788002006 ATP binding site [chemical binding]; other site 1225788002007 substrate binding site [chemical binding]; other site 1225788002008 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1225788002009 MgtC family; Region: MgtC; pfam02308 1225788002010 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1225788002011 Na binding site [ion binding]; other site 1225788002012 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1225788002013 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1225788002014 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1225788002015 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1225788002016 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1225788002017 GatB domain; Region: GatB_Yqey; pfam02637 1225788002018 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788002019 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788002020 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1225788002021 Protein export membrane protein; Region: SecD_SecF; cl14618 1225788002022 putative lipid kinase; Reviewed; Region: PRK13337 1225788002023 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1225788002024 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1225788002025 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1225788002026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788002027 S-adenosylmethionine binding site [chemical binding]; other site 1225788002028 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1225788002029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788002030 active site 1225788002031 phosphorylation site [posttranslational modification] 1225788002032 intermolecular recognition site; other site 1225788002033 dimerization interface [polypeptide binding]; other site 1225788002034 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1225788002035 DNA binding residues [nucleotide binding] 1225788002036 dimerization interface [polypeptide binding]; other site 1225788002037 acyl carrier protein; Provisional; Region: acpP; PRK00982 1225788002038 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1225788002039 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1225788002040 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1225788002041 dimer interface [polypeptide binding]; other site 1225788002042 active site 1225788002043 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1225788002044 active site 1225788002045 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1225788002046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1225788002047 NAD(P) binding site [chemical binding]; other site 1225788002048 active site 1225788002049 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1225788002050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1225788002051 Walker A/P-loop; other site 1225788002052 ATP binding site [chemical binding]; other site 1225788002053 Q-loop/lid; other site 1225788002054 ABC transporter signature motif; other site 1225788002055 Walker B; other site 1225788002056 D-loop; other site 1225788002057 H-loop/switch region; other site 1225788002058 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1225788002059 Protein of unknown function, DUF600; Region: DUF600; cl04640 1225788002060 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1225788002061 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 1225788002062 Protein of unknown function, DUF600; Region: DUF600; pfam04634 1225788002063 Protein of unknown function, DUF600; Region: DUF600; cl04640 1225788002064 Protein of unknown function, DUF600; Region: DUF600; pfam04634 1225788002065 LXG domain of WXG superfamily; Region: LXG; pfam04740 1225788002066 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1225788002067 LXG domain of WXG superfamily; Region: LXG; pfam04740 1225788002068 hypothetical protein; Provisional; Region: PRK12378 1225788002069 CotJB protein; Region: CotJB; pfam12652 1225788002070 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1225788002071 dimanganese center [ion binding]; other site 1225788002072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788002073 Coenzyme A binding pocket [chemical binding]; other site 1225788002074 YesK-like protein; Region: YesK; pfam14150 1225788002075 Predicted membrane protein [Function unknown]; Region: COG2323 1225788002076 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1225788002077 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1225788002078 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1225788002079 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1225788002080 Uncharacterized small protein [Function unknown]; Region: COG5583 1225788002081 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1225788002082 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1225788002083 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788002084 MarR family; Region: MarR; pfam01047 1225788002085 hypothetical protein; Provisional; Region: PRK06847 1225788002086 hypothetical protein; Provisional; Region: PRK07236 1225788002087 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1225788002088 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1225788002089 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1225788002090 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1225788002091 Cytochrome P450; Region: p450; pfam00067 1225788002092 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1225788002093 Flavodoxin; Region: Flavodoxin_1; pfam00258 1225788002094 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1225788002095 FAD binding pocket [chemical binding]; other site 1225788002096 FAD binding motif [chemical binding]; other site 1225788002097 catalytic residues [active] 1225788002098 NAD binding pocket [chemical binding]; other site 1225788002099 phosphate binding motif [ion binding]; other site 1225788002100 beta-alpha-beta structure motif; other site 1225788002101 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1225788002102 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1225788002103 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1225788002104 Walker A/P-loop; other site 1225788002105 ATP binding site [chemical binding]; other site 1225788002106 Q-loop/lid; other site 1225788002107 ABC transporter signature motif; other site 1225788002108 Walker B; other site 1225788002109 D-loop; other site 1225788002110 H-loop/switch region; other site 1225788002111 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1225788002112 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1225788002113 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1225788002114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1225788002115 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1225788002116 YcaO-like family; Region: YcaO; pfam02624 1225788002117 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1225788002118 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1225788002119 putative FMN binding site [chemical binding]; other site 1225788002120 NADPH bind site [chemical binding]; other site 1225788002121 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1225788002122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788002123 S-adenosylmethionine binding site [chemical binding]; other site 1225788002124 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1225788002125 Sulfatase; Region: Sulfatase; pfam00884 1225788002126 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1225788002127 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1225788002128 substrate binding site; other site 1225788002129 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1225788002130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1225788002131 NAD(P) binding site [chemical binding]; other site 1225788002132 active site 1225788002133 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1225788002134 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1225788002135 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1225788002136 active site 1225788002137 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1225788002138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788002139 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788002140 putative substrate translocation pore; other site 1225788002141 amino acid transporter; Region: 2A0306; TIGR00909 1225788002142 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1225788002143 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1225788002144 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1225788002145 NAD(P) binding site [chemical binding]; other site 1225788002146 catalytic residues [active] 1225788002147 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1225788002148 dimer interface [polypeptide binding]; other site 1225788002149 putative CheW interface [polypeptide binding]; other site 1225788002150 oxidoreductase; Provisional; Region: PRK07985 1225788002151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1225788002152 NAD(P) binding site [chemical binding]; other site 1225788002153 active site 1225788002154 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1225788002155 putative metal binding site; other site 1225788002156 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1225788002157 binding surface 1225788002158 TPR motif; other site 1225788002159 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1225788002160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1225788002161 Walker A/P-loop; other site 1225788002162 ATP binding site [chemical binding]; other site 1225788002163 Q-loop/lid; other site 1225788002164 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1225788002165 ABC transporter signature motif; other site 1225788002166 Walker B; other site 1225788002167 D-loop; other site 1225788002168 ABC transporter; Region: ABC_tran_2; pfam12848 1225788002169 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1225788002170 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1225788002171 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1225788002172 DNA binding residues [nucleotide binding] 1225788002173 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1225788002174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788002175 putative substrate translocation pore; other site 1225788002176 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1225788002177 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1225788002178 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1225788002179 ABC transporter; Region: ABC_tran_2; pfam12848 1225788002180 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1225788002181 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1225788002182 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1225788002183 ATP binding site [chemical binding]; other site 1225788002184 Mg++ binding site [ion binding]; other site 1225788002185 motif III; other site 1225788002186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1225788002187 nucleotide binding region [chemical binding]; other site 1225788002188 ATP-binding site [chemical binding]; other site 1225788002189 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1225788002190 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1225788002191 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1225788002192 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1225788002193 NAD(P) binding site [chemical binding]; other site 1225788002194 substrate binding site [chemical binding]; other site 1225788002195 dimer interface [polypeptide binding]; other site 1225788002196 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1225788002197 Heat induced stress protein YflT; Region: YflT; pfam11181 1225788002198 Amb_all domain; Region: Amb_all; smart00656 1225788002199 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1225788002200 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1225788002201 transmembrane helices; other site 1225788002202 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1225788002203 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1225788002204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788002205 dimer interface [polypeptide binding]; other site 1225788002206 phosphorylation site [posttranslational modification] 1225788002207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788002208 ATP binding site [chemical binding]; other site 1225788002209 Mg2+ binding site [ion binding]; other site 1225788002210 G-X-G motif; other site 1225788002211 Response regulator receiver domain; Region: Response_reg; pfam00072 1225788002212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788002213 active site 1225788002214 phosphorylation site [posttranslational modification] 1225788002215 intermolecular recognition site; other site 1225788002216 dimerization interface [polypeptide binding]; other site 1225788002217 Histidine kinase; Region: His_kinase; pfam06580 1225788002218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788002219 ATP binding site [chemical binding]; other site 1225788002220 Mg2+ binding site [ion binding]; other site 1225788002221 G-X-G motif; other site 1225788002222 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1225788002223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788002224 active site 1225788002225 phosphorylation site [posttranslational modification] 1225788002226 intermolecular recognition site; other site 1225788002227 dimerization interface [polypeptide binding]; other site 1225788002228 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1225788002229 DNA binding site [nucleotide binding] 1225788002230 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1225788002231 Collagen binding domain; Region: Collagen_bind; pfam05737 1225788002232 Collagen binding domain; Region: Collagen_bind; pfam05737 1225788002233 Collagen binding domain; Region: Collagen_bind; pfam05737 1225788002234 Cna protein B-type domain; Region: Cna_B; pfam05738 1225788002235 Cna protein B-type domain; Region: Cna_B; pfam05738 1225788002236 Cna protein B-type domain; Region: Cna_B; pfam05738 1225788002237 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1225788002238 Cna protein B-type domain; Region: Cna_B; pfam05738 1225788002239 Cna protein B-type domain; Region: Cna_B; pfam05738 1225788002240 Cna protein B-type domain; Region: Cna_B; pfam05738 1225788002241 Cna protein B-type domain; Region: Cna_B; pfam05738 1225788002242 Cna protein B-type domain; Region: Cna_B; pfam05738 1225788002243 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1225788002244 active site 1225788002245 catalytic site [active] 1225788002246 'potential frameshift: common BLAST hit: gi|387897256|ref|YP_006327552.1| two-component system, CitB family, cit operon sensor histidine' 1225788002247 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1225788002248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788002249 active site 1225788002250 phosphorylation site [posttranslational modification] 1225788002251 intermolecular recognition site; other site 1225788002252 dimerization interface [polypeptide binding]; other site 1225788002253 Transcriptional regulator; Region: CitT; pfam12431 1225788002254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1225788002255 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1225788002256 Citrate transporter; Region: CitMHS; pfam03600 1225788002257 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1225788002258 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1225788002259 active site 1225788002260 dimer interface [polypeptide binding]; other site 1225788002261 acylphosphatase; Provisional; Region: PRK14420 1225788002262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1225788002263 MOSC domain; Region: MOSC; pfam03473 1225788002264 3-alpha domain; Region: 3-alpha; pfam03475 1225788002265 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1225788002266 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1225788002267 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1225788002268 active site 1225788002269 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1225788002270 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1225788002271 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1225788002272 active site turn [active] 1225788002273 phosphorylation site [posttranslational modification] 1225788002274 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1225788002275 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1225788002276 Sulfatase; Region: Sulfatase; pfam00884 1225788002277 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1225788002278 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1225788002279 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1225788002280 putative dimer interface [polypeptide binding]; other site 1225788002281 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1225788002282 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1225788002283 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1225788002284 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1225788002285 active site turn [active] 1225788002286 phosphorylation site [posttranslational modification] 1225788002287 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1225788002288 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1225788002289 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1225788002290 Ca binding site [ion binding]; other site 1225788002291 active site 1225788002292 catalytic site [active] 1225788002293 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1225788002294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788002295 DNA-binding site [nucleotide binding]; DNA binding site 1225788002296 UTRA domain; Region: UTRA; pfam07702 1225788002297 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1225788002298 dimer interface [polypeptide binding]; other site 1225788002299 FMN binding site [chemical binding]; other site 1225788002300 YibE/F-like protein; Region: YibE_F; pfam07907 1225788002301 YibE/F-like protein; Region: YibE_F; pfam07907 1225788002302 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1225788002303 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1225788002304 active site 1225788002305 metal binding site [ion binding]; metal-binding site 1225788002306 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1225788002307 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1225788002308 active site 1225788002309 metal binding site [ion binding]; metal-binding site 1225788002310 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1225788002311 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1225788002312 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1225788002313 proposed catalytic triad [active] 1225788002314 conserved cys residue [active] 1225788002315 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1225788002316 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1225788002317 DNA binding site [nucleotide binding] 1225788002318 domain linker motif; other site 1225788002319 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1225788002320 putative dimerization interface [polypeptide binding]; other site 1225788002321 putative ligand binding site [chemical binding]; other site 1225788002322 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1225788002323 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1225788002324 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1225788002325 shikimate binding site; other site 1225788002326 NAD(P) binding site [chemical binding]; other site 1225788002327 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1225788002328 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1225788002329 active site 1225788002330 catalytic residue [active] 1225788002331 dimer interface [polypeptide binding]; other site 1225788002332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788002333 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788002334 putative substrate translocation pore; other site 1225788002335 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1225788002336 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1225788002337 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1225788002338 active site 1225788002339 ATP synthase CF1 alpha subunit; Region: atpA; CHL00059 1225788002340 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1225788002341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788002342 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788002343 putative substrate translocation pore; other site 1225788002344 calcium/proton exchanger (cax); Region: cax; TIGR00378 1225788002345 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1225788002346 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1225788002347 YfkD-like protein; Region: YfkD; pfam14167 1225788002348 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1225788002349 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1225788002350 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1225788002351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1225788002352 FeS/SAM binding site; other site 1225788002353 YfkB-like domain; Region: YfkB; pfam08756 1225788002354 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1225788002355 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1225788002356 NodB motif; other site 1225788002357 active site 1225788002358 catalytic site [active] 1225788002359 Cd binding site [ion binding]; other site 1225788002360 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1225788002361 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1225788002362 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1225788002363 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1225788002364 oligomer interface [polypeptide binding]; other site 1225788002365 metal binding site [ion binding]; metal-binding site 1225788002366 metal binding site [ion binding]; metal-binding site 1225788002367 putative Cl binding site [ion binding]; other site 1225788002368 aspartate ring; other site 1225788002369 basic sphincter; other site 1225788002370 hydrophobic gate; other site 1225788002371 periplasmic entrance; other site 1225788002372 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1225788002373 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1225788002374 minor groove reading motif; other site 1225788002375 helix-hairpin-helix signature motif; other site 1225788002376 substrate binding pocket [chemical binding]; other site 1225788002377 active site 1225788002378 TRAM domain; Region: TRAM; pfam01938 1225788002379 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1225788002380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788002381 S-adenosylmethionine binding site [chemical binding]; other site 1225788002382 YfzA-like protein; Region: YfzA; pfam14118 1225788002383 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1225788002384 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1225788002385 FMN binding site [chemical binding]; other site 1225788002386 active site 1225788002387 catalytic residues [active] 1225788002388 substrate binding site [chemical binding]; other site 1225788002389 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1225788002390 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1225788002391 tetramer interface [polypeptide binding]; other site 1225788002392 TPP-binding site [chemical binding]; other site 1225788002393 heterodimer interface [polypeptide binding]; other site 1225788002394 phosphorylation loop region [posttranslational modification] 1225788002395 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1225788002396 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1225788002397 alpha subunit interface [polypeptide binding]; other site 1225788002398 TPP binding site [chemical binding]; other site 1225788002399 heterodimer interface [polypeptide binding]; other site 1225788002400 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1225788002401 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1225788002402 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1225788002403 E3 interaction surface; other site 1225788002404 lipoyl attachment site [posttranslational modification]; other site 1225788002405 e3 binding domain; Region: E3_binding; pfam02817 1225788002406 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1225788002407 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1225788002408 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1225788002409 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1225788002410 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1225788002411 GAF domain; Region: GAF; pfam01590 1225788002412 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788002413 Walker A motif; other site 1225788002414 ATP binding site [chemical binding]; other site 1225788002415 Walker B motif; other site 1225788002416 arginine finger; other site 1225788002417 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1225788002418 Small acid-soluble spore protein H family; Region: SspH; pfam08141 1225788002419 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1225788002420 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1225788002421 NAD binding site [chemical binding]; other site 1225788002422 sugar binding site [chemical binding]; other site 1225788002423 divalent metal binding site [ion binding]; other site 1225788002424 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1225788002425 dimer interface [polypeptide binding]; other site 1225788002426 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1225788002427 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1225788002428 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1225788002429 putative active site [active] 1225788002430 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1225788002431 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1225788002432 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1225788002433 active site turn [active] 1225788002434 phosphorylation site [posttranslational modification] 1225788002435 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1225788002436 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1225788002437 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1225788002438 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1225788002439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1225788002440 Walker A/P-loop; other site 1225788002441 ATP binding site [chemical binding]; other site 1225788002442 Q-loop/lid; other site 1225788002443 ABC transporter signature motif; other site 1225788002444 Walker B; other site 1225788002445 D-loop; other site 1225788002446 H-loop/switch region; other site 1225788002447 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1225788002448 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1225788002449 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1225788002450 Walker A/P-loop; other site 1225788002451 ATP binding site [chemical binding]; other site 1225788002452 Q-loop/lid; other site 1225788002453 ABC transporter signature motif; other site 1225788002454 Walker B; other site 1225788002455 D-loop; other site 1225788002456 H-loop/switch region; other site 1225788002457 Predicted membrane protein [Function unknown]; Region: COG2259 1225788002458 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1225788002459 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1225788002460 putative metal binding site [ion binding]; other site 1225788002461 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1225788002462 active site 1225788002463 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1225788002464 UbiA prenyltransferase family; Region: UbiA; pfam01040 1225788002465 Predicted transcriptional regulators [Transcription]; Region: COG1695 1225788002466 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1225788002467 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1225788002468 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1225788002469 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1225788002470 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1225788002471 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1225788002472 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1225788002473 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1225788002474 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1225788002475 RNAase interaction site [polypeptide binding]; other site 1225788002476 metal-dependent hydrolase; Provisional; Region: PRK13291 1225788002477 DinB superfamily; Region: DinB_2; pfam12867 1225788002478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788002479 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788002480 putative substrate translocation pore; other site 1225788002481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788002482 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788002483 MarR family; Region: MarR; pfam01047 1225788002484 Predicted integral membrane protein [Function unknown]; Region: COG0392 1225788002485 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1225788002486 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1225788002487 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1225788002488 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1225788002489 putative FMN binding site [chemical binding]; other site 1225788002490 YfhD-like protein; Region: YfhD; pfam14151 1225788002491 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1225788002492 TIGR01777 family protein; Region: yfcH 1225788002493 putative NAD(P) binding site [chemical binding]; other site 1225788002494 putative active site [active] 1225788002495 recombination regulator RecX; Provisional; Region: recX; PRK14135 1225788002496 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1225788002497 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1225788002498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788002499 putative substrate translocation pore; other site 1225788002500 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1225788002501 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1225788002502 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 1225788002503 WVELL protein; Region: WVELL; pfam14043 1225788002504 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1225788002505 Bacterial SH3 domain; Region: SH3_3; cl17532 1225788002506 SdpI/YhfL protein family; Region: SdpI; pfam13630 1225788002507 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1225788002508 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1225788002509 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1225788002510 Ligand binding site; other site 1225788002511 Putative Catalytic site; other site 1225788002512 DXD motif; other site 1225788002513 Predicted membrane protein [Function unknown]; Region: COG4485 1225788002514 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1225788002515 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1225788002516 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1225788002517 minor groove reading motif; other site 1225788002518 helix-hairpin-helix signature motif; other site 1225788002519 substrate binding pocket [chemical binding]; other site 1225788002520 active site 1225788002521 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1225788002522 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1225788002523 DNA binding and oxoG recognition site [nucleotide binding] 1225788002524 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1225788002525 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1225788002526 putative NAD(P) binding site [chemical binding]; other site 1225788002527 active site 1225788002528 YgaB-like protein; Region: YgaB; pfam14182 1225788002529 hypothetical protein; Provisional; Region: PRK13662 1225788002530 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1225788002531 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1225788002532 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1225788002533 Walker A/P-loop; other site 1225788002534 ATP binding site [chemical binding]; other site 1225788002535 Q-loop/lid; other site 1225788002536 ABC transporter signature motif; other site 1225788002537 Walker B; other site 1225788002538 D-loop; other site 1225788002539 H-loop/switch region; other site 1225788002540 Predicted membrane protein [Function unknown]; Region: COG4129 1225788002541 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1225788002542 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1225788002543 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1225788002544 inhibitor-cofactor binding pocket; inhibition site 1225788002545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788002546 catalytic residue [active] 1225788002547 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1225788002548 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1225788002549 catalytic triad [active] 1225788002550 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1225788002551 metal binding site 2 [ion binding]; metal-binding site 1225788002552 putative DNA binding helix; other site 1225788002553 metal binding site 1 [ion binding]; metal-binding site 1225788002554 dimer interface [polypeptide binding]; other site 1225788002555 structural Zn2+ binding site [ion binding]; other site 1225788002556 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1225788002557 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1225788002558 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1225788002559 active site pocket [active] 1225788002560 oxyanion hole [active] 1225788002561 catalytic triad [active] 1225788002562 active site nucleophile [active] 1225788002563 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1225788002564 ThiC-associated domain; Region: ThiC-associated; pfam13667 1225788002565 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1225788002566 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1225788002567 FAD binding domain; Region: FAD_binding_4; pfam01565 1225788002568 Berberine and berberine like; Region: BBE; pfam08031 1225788002569 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1225788002570 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1225788002571 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1225788002572 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1225788002573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788002574 dimer interface [polypeptide binding]; other site 1225788002575 conserved gate region; other site 1225788002576 putative PBP binding loops; other site 1225788002577 ABC-ATPase subunit interface; other site 1225788002578 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1225788002579 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1225788002580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788002581 dimer interface [polypeptide binding]; other site 1225788002582 conserved gate region; other site 1225788002583 putative PBP binding loops; other site 1225788002584 ABC-ATPase subunit interface; other site 1225788002585 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1225788002586 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1225788002587 Walker A/P-loop; other site 1225788002588 ATP binding site [chemical binding]; other site 1225788002589 Q-loop/lid; other site 1225788002590 ABC transporter signature motif; other site 1225788002591 Walker B; other site 1225788002592 D-loop; other site 1225788002593 H-loop/switch region; other site 1225788002594 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1225788002595 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1225788002596 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1225788002597 Walker A/P-loop; other site 1225788002598 ATP binding site [chemical binding]; other site 1225788002599 Q-loop/lid; other site 1225788002600 ABC transporter signature motif; other site 1225788002601 Walker B; other site 1225788002602 D-loop; other site 1225788002603 H-loop/switch region; other site 1225788002604 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1225788002605 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1225788002606 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1225788002607 tetramer interface [polypeptide binding]; other site 1225788002608 heme binding pocket [chemical binding]; other site 1225788002609 NADPH binding site [chemical binding]; other site 1225788002610 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1225788002611 active site 1225788002612 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1225788002613 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1225788002614 Walker A/P-loop; other site 1225788002615 ATP binding site [chemical binding]; other site 1225788002616 Q-loop/lid; other site 1225788002617 ABC transporter signature motif; other site 1225788002618 Walker B; other site 1225788002619 D-loop; other site 1225788002620 H-loop/switch region; other site 1225788002621 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1225788002622 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1225788002623 substrate binding pocket [chemical binding]; other site 1225788002624 membrane-bound complex binding site; other site 1225788002625 hinge residues; other site 1225788002626 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1225788002627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788002628 dimer interface [polypeptide binding]; other site 1225788002629 conserved gate region; other site 1225788002630 putative PBP binding loops; other site 1225788002631 ABC-ATPase subunit interface; other site 1225788002632 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1225788002633 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1225788002634 active site 1225788002635 dimer interface [polypeptide binding]; other site 1225788002636 non-prolyl cis peptide bond; other site 1225788002637 insertion regions; other site 1225788002638 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1225788002639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788002640 non-specific DNA binding site [nucleotide binding]; other site 1225788002641 salt bridge; other site 1225788002642 sequence-specific DNA binding site [nucleotide binding]; other site 1225788002643 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1225788002644 epoxyqueuosine reductase; Region: TIGR00276 1225788002645 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1225788002646 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1225788002647 Putative amidase domain; Region: Amidase_6; pfam12671 1225788002648 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 1225788002649 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1225788002650 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1225788002651 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1225788002652 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1225788002653 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1225788002654 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1225788002655 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1225788002656 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788002657 MarR family; Region: MarR; pfam01047 1225788002658 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1225788002659 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1225788002660 carboxyltransferase (CT) interaction site; other site 1225788002661 biotinylation site [posttranslational modification]; other site 1225788002662 HlyD family secretion protein; Region: HlyD_3; pfam13437 1225788002663 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1225788002664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788002665 putative substrate translocation pore; other site 1225788002666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788002667 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1225788002668 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1225788002669 Predicted transcriptional regulators [Transcription]; Region: COG1725 1225788002670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788002671 DNA-binding site [nucleotide binding]; DNA binding site 1225788002672 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1225788002673 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1225788002674 Walker A/P-loop; other site 1225788002675 ATP binding site [chemical binding]; other site 1225788002676 Q-loop/lid; other site 1225788002677 ABC transporter signature motif; other site 1225788002678 Walker B; other site 1225788002679 D-loop; other site 1225788002680 H-loop/switch region; other site 1225788002681 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1225788002682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1225788002683 Walker A/P-loop; other site 1225788002684 ATP binding site [chemical binding]; other site 1225788002685 Q-loop/lid; other site 1225788002686 ABC transporter signature motif; other site 1225788002687 Walker B; other site 1225788002688 D-loop; other site 1225788002689 H-loop/switch region; other site 1225788002690 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1225788002691 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1225788002692 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1225788002693 DNA-binding site [nucleotide binding]; DNA binding site 1225788002694 RNA-binding motif; other site 1225788002695 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1225788002696 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1225788002697 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1225788002698 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1225788002699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1225788002700 metal binding site [ion binding]; metal-binding site 1225788002701 active site 1225788002702 I-site; other site 1225788002703 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1225788002704 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1225788002705 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1225788002706 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1225788002707 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1225788002708 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1225788002709 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1225788002710 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1225788002711 putative active site [active] 1225788002712 putative metal binding site [ion binding]; other site 1225788002713 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1225788002714 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 1225788002715 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1225788002716 active site 1225788002717 catalytic site [active] 1225788002718 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1225788002719 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1225788002720 active site 1225788002721 FOG: CBS domain [General function prediction only]; Region: COG0517 1225788002722 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1225788002723 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1225788002724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788002725 motif II; other site 1225788002726 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1225788002727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788002728 Coenzyme A binding pocket [chemical binding]; other site 1225788002729 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1225788002730 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1225788002731 putative active site [active] 1225788002732 catalytic triad [active] 1225788002733 putative dimer interface [polypeptide binding]; other site 1225788002734 aminotransferase; Validated; Region: PRK07678 1225788002735 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1225788002736 inhibitor-cofactor binding pocket; inhibition site 1225788002737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788002738 catalytic residue [active] 1225788002739 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1225788002740 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1225788002741 amphipathic channel; other site 1225788002742 Asn-Pro-Ala signature motifs; other site 1225788002743 glycerol kinase; Provisional; Region: glpK; PRK00047 1225788002744 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1225788002745 N- and C-terminal domain interface [polypeptide binding]; other site 1225788002746 active site 1225788002747 MgATP binding site [chemical binding]; other site 1225788002748 catalytic site [active] 1225788002749 metal binding site [ion binding]; metal-binding site 1225788002750 glycerol binding site [chemical binding]; other site 1225788002751 homotetramer interface [polypeptide binding]; other site 1225788002752 homodimer interface [polypeptide binding]; other site 1225788002753 FBP binding site [chemical binding]; other site 1225788002754 protein IIAGlc interface [polypeptide binding]; other site 1225788002755 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1225788002756 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1225788002757 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1225788002758 active site 1225788002759 substrate binding site [chemical binding]; other site 1225788002760 metal binding site [ion binding]; metal-binding site 1225788002761 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1225788002762 GAF domain; Region: GAF; pfam01590 1225788002763 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1225788002764 Histidine kinase; Region: HisKA_3; pfam07730 1225788002765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788002766 ATP binding site [chemical binding]; other site 1225788002767 Mg2+ binding site [ion binding]; other site 1225788002768 G-X-G motif; other site 1225788002769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1225788002770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788002771 active site 1225788002772 phosphorylation site [posttranslational modification] 1225788002773 intermolecular recognition site; other site 1225788002774 dimerization interface [polypeptide binding]; other site 1225788002775 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1225788002776 DNA binding residues [nucleotide binding] 1225788002777 dimerization interface [polypeptide binding]; other site 1225788002778 Predicted flavoprotein [General function prediction only]; Region: COG0431 1225788002779 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1225788002780 YhdB-like protein; Region: YhdB; pfam14148 1225788002781 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1225788002782 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788002783 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788002784 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1225788002785 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788002786 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788002787 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788002788 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1225788002789 NlpC/P60 family; Region: NLPC_P60; pfam00877 1225788002790 Transcriptional regulator; Region: Rrf2; cl17282 1225788002791 Rrf2 family protein; Region: rrf2_super; TIGR00738 1225788002792 Conserved TM helix; Region: TM_helix; pfam05552 1225788002793 Conserved TM helix; Region: TM_helix; pfam05552 1225788002794 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1225788002795 SpoVR like protein; Region: SpoVR; pfam04293 1225788002796 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1225788002797 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1225788002798 dimer interface [polypeptide binding]; other site 1225788002799 active site 1225788002800 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788002801 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788002802 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1225788002803 NlpC/P60 family; Region: NLPC_P60; pfam00877 1225788002804 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788002805 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788002806 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1225788002807 dimerization interface [polypeptide binding]; other site 1225788002808 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1225788002809 dimer interface [polypeptide binding]; other site 1225788002810 Citrate synthase; Region: Citrate_synt; pfam00285 1225788002811 active site 1225788002812 citrylCoA binding site [chemical binding]; other site 1225788002813 oxalacetate/citrate binding site [chemical binding]; other site 1225788002814 coenzyme A binding site [chemical binding]; other site 1225788002815 catalytic triad [active] 1225788002816 short chain dehydrogenase; Provisional; Region: PRK06701 1225788002817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1225788002818 NAD(P) binding site [chemical binding]; other site 1225788002819 active site 1225788002820 amino acid transporter; Region: 2A0306; TIGR00909 1225788002821 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1225788002822 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1225788002823 Na2 binding site [ion binding]; other site 1225788002824 putative substrate binding site 1 [chemical binding]; other site 1225788002825 Na binding site 1 [ion binding]; other site 1225788002826 putative substrate binding site 2 [chemical binding]; other site 1225788002827 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1225788002828 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1225788002829 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1225788002830 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1225788002831 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1225788002832 DNA binding residues [nucleotide binding] 1225788002833 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1225788002834 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1225788002835 putative acyl-acceptor binding pocket; other site 1225788002836 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1225788002837 Domain of unknown function DUF21; Region: DUF21; pfam01595 1225788002838 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1225788002839 Transporter associated domain; Region: CorC_HlyC; smart01091 1225788002840 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1225788002841 aspartate aminotransferase; Provisional; Region: PRK06836 1225788002842 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1225788002843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788002844 homodimer interface [polypeptide binding]; other site 1225788002845 catalytic residue [active] 1225788002846 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1225788002847 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1225788002848 dimer interface [polypeptide binding]; other site 1225788002849 active site 1225788002850 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1225788002851 Domain of unknown function DUF21; Region: DUF21; pfam01595 1225788002852 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1225788002853 Transporter associated domain; Region: CorC_HlyC; smart01091 1225788002854 camphor resistance protein CrcB; Provisional; Region: PRK14213 1225788002855 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1225788002856 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1225788002857 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1225788002858 active site 1225788002859 catalytic site [active] 1225788002860 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1225788002861 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1225788002862 NAD-dependent deacetylase; Provisional; Region: PRK00481 1225788002863 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1225788002864 NAD+ binding site [chemical binding]; other site 1225788002865 substrate binding site [chemical binding]; other site 1225788002866 Zn binding site [ion binding]; other site 1225788002867 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1225788002868 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1225788002869 NodB motif; other site 1225788002870 active site 1225788002871 catalytic site [active] 1225788002872 Zn binding site [ion binding]; other site 1225788002873 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1225788002874 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1225788002875 homodimer interface [polypeptide binding]; other site 1225788002876 substrate-cofactor binding pocket; other site 1225788002877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788002878 catalytic residue [active] 1225788002879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788002880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788002881 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1225788002882 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1225788002883 Ligand Binding Site [chemical binding]; other site 1225788002884 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1225788002885 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1225788002886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1225788002887 Walker A/P-loop; other site 1225788002888 ATP binding site [chemical binding]; other site 1225788002889 Q-loop/lid; other site 1225788002890 ABC transporter signature motif; other site 1225788002891 Walker B; other site 1225788002892 D-loop; other site 1225788002893 H-loop/switch region; other site 1225788002894 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1225788002895 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1225788002896 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1225788002897 Walker A/P-loop; other site 1225788002898 ATP binding site [chemical binding]; other site 1225788002899 Q-loop/lid; other site 1225788002900 ABC transporter signature motif; other site 1225788002901 Walker B; other site 1225788002902 D-loop; other site 1225788002903 H-loop/switch region; other site 1225788002904 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1225788002905 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1225788002906 NAD binding site [chemical binding]; other site 1225788002907 substrate binding site [chemical binding]; other site 1225788002908 putative active site [active] 1225788002909 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1225788002910 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1225788002911 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1225788002912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1225788002913 hypothetical protein; Provisional; Region: PRK13676 1225788002914 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1225788002915 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1225788002916 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1225788002917 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788002918 active site 1225788002919 motif I; other site 1225788002920 motif II; other site 1225788002921 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1225788002922 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1225788002923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1225788002924 FeS/SAM binding site; other site 1225788002925 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1225788002926 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1225788002927 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1225788002928 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1225788002929 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1225788002930 TrkA-C domain; Region: TrkA_C; pfam02080 1225788002931 enoyl-CoA hydratase; Provisional; Region: PRK07659 1225788002932 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1225788002933 substrate binding site [chemical binding]; other site 1225788002934 oxyanion hole (OAH) forming residues; other site 1225788002935 trimer interface [polypeptide binding]; other site 1225788002936 YhzD-like protein; Region: YhzD; pfam14120 1225788002937 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1225788002938 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1225788002939 Walker A/P-loop; other site 1225788002940 ATP binding site [chemical binding]; other site 1225788002941 Q-loop/lid; other site 1225788002942 ABC transporter signature motif; other site 1225788002943 Walker B; other site 1225788002944 D-loop; other site 1225788002945 H-loop/switch region; other site 1225788002946 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1225788002947 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1225788002948 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1225788002949 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1225788002950 active site 1225788002951 metal binding site [ion binding]; metal-binding site 1225788002952 DNA binding site [nucleotide binding] 1225788002953 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1225788002954 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1225788002955 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1225788002956 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1225788002957 generic binding surface II; other site 1225788002958 generic binding surface I; other site 1225788002959 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1225788002960 Zn2+ binding site [ion binding]; other site 1225788002961 Mg2+ binding site [ion binding]; other site 1225788002962 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1225788002963 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 1225788002964 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1225788002965 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1225788002966 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1225788002967 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1225788002968 transcriptional regulator Hpr; Provisional; Region: PRK13777 1225788002969 MarR family; Region: MarR; pfam01047 1225788002970 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1225788002971 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1225788002972 homodimer interface [polypeptide binding]; other site 1225788002973 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1225788002974 substrate-cofactor binding pocket; other site 1225788002975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788002976 catalytic residue [active] 1225788002977 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1225788002978 HIT family signature motif; other site 1225788002979 catalytic residue [active] 1225788002980 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1225788002981 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1225788002982 Walker A/P-loop; other site 1225788002983 ATP binding site [chemical binding]; other site 1225788002984 Q-loop/lid; other site 1225788002985 ABC transporter signature motif; other site 1225788002986 Walker B; other site 1225788002987 D-loop; other site 1225788002988 H-loop/switch region; other site 1225788002989 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1225788002990 EcsC protein family; Region: EcsC; pfam12787 1225788002991 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1225788002992 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1225788002993 metal binding site [ion binding]; metal-binding site 1225788002994 dimer interface [polypeptide binding]; other site 1225788002995 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1225788002996 Transglycosylase; Region: Transgly; pfam00912 1225788002997 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1225788002998 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1225788002999 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1225788003000 substrate binding site [chemical binding]; other site 1225788003001 active site 1225788003002 ferrochelatase; Provisional; Region: PRK12435 1225788003003 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1225788003004 C-terminal domain interface [polypeptide binding]; other site 1225788003005 active site 1225788003006 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1225788003007 active site 1225788003008 N-terminal domain interface [polypeptide binding]; other site 1225788003009 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1225788003010 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1225788003011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788003012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788003013 Predicted membrane protein [Function unknown]; Region: COG1511 1225788003014 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1225788003015 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1225788003016 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1225788003017 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1225788003018 dimer interface [polypeptide binding]; other site 1225788003019 active site 1225788003020 CoA binding pocket [chemical binding]; other site 1225788003021 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1225788003022 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1225788003023 putative oligomer interface [polypeptide binding]; other site 1225788003024 putative active site [active] 1225788003025 metal binding site [ion binding]; metal-binding site 1225788003026 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1225788003027 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1225788003028 YhfH-like protein; Region: YhfH; pfam14149 1225788003029 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1225788003030 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1225788003031 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1225788003032 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1225788003033 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1225788003034 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1225788003035 NAD(P) binding site [chemical binding]; other site 1225788003036 putative active site [active] 1225788003037 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1225788003038 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1225788003039 acyl-activating enzyme (AAE) consensus motif; other site 1225788003040 putative AMP binding site [chemical binding]; other site 1225788003041 putative active site [active] 1225788003042 putative CoA binding site [chemical binding]; other site 1225788003043 Peptidase family M48; Region: Peptidase_M48; pfam01435 1225788003044 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1225788003045 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1225788003046 active site 1225788003047 catalytic residues [active] 1225788003048 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1225788003049 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1225788003050 siderophore binding site; other site 1225788003051 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1225788003052 catalytic core [active] 1225788003053 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1225788003054 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1225788003055 dimer interface [polypeptide binding]; other site 1225788003056 active site 1225788003057 acyl-CoA synthetase; Validated; Region: PRK07638 1225788003058 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1225788003059 acyl-activating enzyme (AAE) consensus motif; other site 1225788003060 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1225788003061 acyl-activating enzyme (AAE) consensus motif; other site 1225788003062 AMP binding site [chemical binding]; other site 1225788003063 active site 1225788003064 CoA binding site [chemical binding]; other site 1225788003065 BioY family; Region: BioY; pfam02632 1225788003066 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1225788003067 heme-binding site [chemical binding]; other site 1225788003068 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1225788003069 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1225788003070 dimer interface [polypeptide binding]; other site 1225788003071 putative CheW interface [polypeptide binding]; other site 1225788003072 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1225788003073 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1225788003074 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1225788003075 [2Fe-2S] cluster binding site [ion binding]; other site 1225788003076 short chain dehydrogenase; Provisional; Region: PRK06701 1225788003077 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1225788003078 NAD binding site [chemical binding]; other site 1225788003079 metal binding site [ion binding]; metal-binding site 1225788003080 active site 1225788003081 A short protein domain of unknown function; Region: IDEAL; smart00914 1225788003082 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1225788003083 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1225788003084 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1225788003085 MepB protein; Region: MepB; pfam08877 1225788003086 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1225788003087 putative binding site; other site 1225788003088 putative dimer interface [polypeptide binding]; other site 1225788003089 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1225788003090 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1225788003091 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1225788003092 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1225788003093 Na binding site [ion binding]; other site 1225788003094 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1225788003095 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1225788003096 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1225788003097 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1225788003098 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1225788003099 Catalytic site [active] 1225788003100 hypothetical protein; Provisional; Region: PRK08244 1225788003101 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1225788003102 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788003103 MarR family; Region: MarR; pfam01047 1225788003104 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1225788003105 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1225788003106 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1225788003107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788003108 putative substrate translocation pore; other site 1225788003109 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788003110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788003111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788003112 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1225788003113 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1225788003114 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1225788003115 dinuclear metal binding motif [ion binding]; other site 1225788003116 Predicted membrane protein [Function unknown]; Region: COG2323 1225788003117 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1225788003118 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1225788003119 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1225788003120 Part of AAA domain; Region: AAA_19; pfam13245 1225788003121 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1225788003122 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 1225788003123 Family description; Region: UvrD_C_2; pfam13538 1225788003124 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1225788003125 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1225788003126 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1225788003127 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1225788003128 active site 1225788003129 metal binding site [ion binding]; metal-binding site 1225788003130 DNA binding site [nucleotide binding] 1225788003131 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1225788003132 potential frameshift: common BLAST hit: gi|387897572|ref|YP_006327868.1| exonuclease 1225788003133 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1225788003134 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1225788003135 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1225788003136 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1225788003137 Spore germination protein GerPC; Region: GerPC; pfam10737 1225788003138 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1225788003139 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1225788003140 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1225788003141 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1225788003142 hypothetical protein; Provisional; Region: PRK13673 1225788003143 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1225788003144 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1225788003145 active site 1225788003146 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1225788003147 dimer interface [polypeptide binding]; other site 1225788003148 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1225788003149 Ligand Binding Site [chemical binding]; other site 1225788003150 Molecular Tunnel; other site 1225788003151 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1225788003152 substrate binding pocket [chemical binding]; other site 1225788003153 substrate-Mg2+ binding site; other site 1225788003154 aspartate-rich region 1; other site 1225788003155 aspartate-rich region 2; other site 1225788003156 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1225788003157 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1225788003158 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1225788003159 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1225788003160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1225788003161 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1225788003162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1225788003163 DinB superfamily; Region: DinB_2; pfam12867 1225788003164 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1225788003165 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1225788003166 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1225788003167 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1225788003168 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1225788003169 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1225788003170 FAD binding site [chemical binding]; other site 1225788003171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1225788003172 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1225788003173 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1225788003174 S1 domain; Region: S1_2; pfam13509 1225788003175 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1225788003176 RNA binding site [nucleotide binding]; other site 1225788003177 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1225788003178 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1225788003179 ligand binding site [chemical binding]; other site 1225788003180 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1225788003181 dimerization interface [polypeptide binding]; other site 1225788003182 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1225788003183 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1225788003184 dimer interface [polypeptide binding]; other site 1225788003185 putative CheW interface [polypeptide binding]; other site 1225788003186 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1225788003187 Cytochrome P450; Region: p450; cl12078 1225788003188 EDD domain protein, DegV family; Region: DegV; TIGR00762 1225788003189 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1225788003190 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1225788003191 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1225788003192 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1225788003193 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1225788003194 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1225788003195 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1225788003196 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1225788003197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788003198 motif II; other site 1225788003199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788003200 esterase; Provisional; Region: PRK10566 1225788003201 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1225788003202 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1225788003203 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1225788003204 active site 1225788003205 metal binding site [ion binding]; metal-binding site 1225788003206 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1225788003207 FAD binding domain; Region: FAD_binding_4; pfam01565 1225788003208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788003209 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788003210 putative substrate translocation pore; other site 1225788003211 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1225788003212 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1225788003213 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1225788003214 heterotetramer interface [polypeptide binding]; other site 1225788003215 active site pocket [active] 1225788003216 cleavage site 1225788003217 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1225788003218 nucleotide binding site [chemical binding]; other site 1225788003219 N-acetyl-L-glutamate binding site [chemical binding]; other site 1225788003220 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1225788003221 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1225788003222 inhibitor-cofactor binding pocket; inhibition site 1225788003223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788003224 catalytic residue [active] 1225788003225 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1225788003226 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1225788003227 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1225788003228 catalytic site [active] 1225788003229 subunit interface [polypeptide binding]; other site 1225788003230 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1225788003231 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1225788003232 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1225788003233 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1225788003234 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1225788003235 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1225788003236 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1225788003237 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1225788003238 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1225788003239 YjzC-like protein; Region: YjzC; pfam14168 1225788003240 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1225788003241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1225788003242 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1225788003243 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1225788003244 putative ligand binding site [chemical binding]; other site 1225788003245 ComZ; Region: ComZ; pfam10815 1225788003246 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1225788003247 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1225788003248 dimer interface [polypeptide binding]; other site 1225788003249 active site 1225788003250 CoA binding pocket [chemical binding]; other site 1225788003251 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1225788003252 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1225788003253 dimer interface [polypeptide binding]; other site 1225788003254 active site 1225788003255 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1225788003256 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1225788003257 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1225788003258 Walker A/P-loop; other site 1225788003259 ATP binding site [chemical binding]; other site 1225788003260 Q-loop/lid; other site 1225788003261 ABC transporter signature motif; other site 1225788003262 Walker B; other site 1225788003263 D-loop; other site 1225788003264 H-loop/switch region; other site 1225788003265 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1225788003266 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1225788003267 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1225788003268 Walker A/P-loop; other site 1225788003269 ATP binding site [chemical binding]; other site 1225788003270 Q-loop/lid; other site 1225788003271 ABC transporter signature motif; other site 1225788003272 Walker B; other site 1225788003273 D-loop; other site 1225788003274 H-loop/switch region; other site 1225788003275 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1225788003276 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1225788003277 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1225788003278 peptide binding site [polypeptide binding]; other site 1225788003279 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1225788003280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788003281 dimer interface [polypeptide binding]; other site 1225788003282 conserved gate region; other site 1225788003283 putative PBP binding loops; other site 1225788003284 ABC-ATPase subunit interface; other site 1225788003285 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1225788003286 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1225788003287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788003288 dimer interface [polypeptide binding]; other site 1225788003289 conserved gate region; other site 1225788003290 putative PBP binding loops; other site 1225788003291 ABC-ATPase subunit interface; other site 1225788003292 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1225788003293 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1225788003294 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1225788003295 active site 1225788003296 HIGH motif; other site 1225788003297 dimer interface [polypeptide binding]; other site 1225788003298 KMSKS motif; other site 1225788003299 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1225788003300 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1225788003301 peptide binding site [polypeptide binding]; other site 1225788003302 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1225788003303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788003304 dimer interface [polypeptide binding]; other site 1225788003305 conserved gate region; other site 1225788003306 putative PBP binding loops; other site 1225788003307 ABC-ATPase subunit interface; other site 1225788003308 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1225788003309 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1225788003310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788003311 dimer interface [polypeptide binding]; other site 1225788003312 conserved gate region; other site 1225788003313 putative PBP binding loops; other site 1225788003314 ABC-ATPase subunit interface; other site 1225788003315 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1225788003316 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1225788003317 Walker A/P-loop; other site 1225788003318 ATP binding site [chemical binding]; other site 1225788003319 Q-loop/lid; other site 1225788003320 ABC transporter signature motif; other site 1225788003321 Walker B; other site 1225788003322 D-loop; other site 1225788003323 H-loop/switch region; other site 1225788003324 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1225788003325 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1225788003326 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1225788003327 Walker A/P-loop; other site 1225788003328 ATP binding site [chemical binding]; other site 1225788003329 Q-loop/lid; other site 1225788003330 ABC transporter signature motif; other site 1225788003331 Walker B; other site 1225788003332 D-loop; other site 1225788003333 H-loop/switch region; other site 1225788003334 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1225788003335 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1225788003336 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1225788003337 Coenzyme A binding pocket [chemical binding]; other site 1225788003338 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1225788003339 ArsC family; Region: ArsC; pfam03960 1225788003340 putative catalytic residues [active] 1225788003341 thiol/disulfide switch; other site 1225788003342 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1225788003343 adaptor protein; Provisional; Region: PRK02315 1225788003344 Competence protein CoiA-like family; Region: CoiA; cl11541 1225788003345 oligoendopeptidase F; Region: pepF; TIGR00181 1225788003346 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1225788003347 active site 1225788003348 Zn binding site [ion binding]; other site 1225788003349 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1225788003350 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1225788003351 catalytic residues [active] 1225788003352 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1225788003353 apolar tunnel; other site 1225788003354 heme binding site [chemical binding]; other site 1225788003355 dimerization interface [polypeptide binding]; other site 1225788003356 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1225788003357 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1225788003358 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1225788003359 catalytic residue [active] 1225788003360 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1225788003361 putative active site [active] 1225788003362 putative metal binding residues [ion binding]; other site 1225788003363 signature motif; other site 1225788003364 putative triphosphate binding site [ion binding]; other site 1225788003365 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1225788003366 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1225788003367 synthetase active site [active] 1225788003368 NTP binding site [chemical binding]; other site 1225788003369 metal binding site [ion binding]; metal-binding site 1225788003370 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1225788003371 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1225788003372 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1225788003373 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1225788003374 active site 1225788003375 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1225788003376 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1225788003377 active site 1225788003378 metal binding site [ion binding]; metal-binding site 1225788003379 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1225788003380 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1225788003381 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1225788003382 TrkA-N domain; Region: TrkA_N; pfam02254 1225788003383 TrkA-C domain; Region: TrkA_C; pfam02080 1225788003384 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1225788003385 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1225788003386 thiamine phosphate binding site [chemical binding]; other site 1225788003387 active site 1225788003388 pyrophosphate binding site [ion binding]; other site 1225788003389 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1225788003390 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1225788003391 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1225788003392 thiS-thiF/thiG interaction site; other site 1225788003393 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1225788003394 ThiS interaction site; other site 1225788003395 putative active site [active] 1225788003396 tetramer interface [polypeptide binding]; other site 1225788003397 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1225788003398 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1225788003399 ATP binding site [chemical binding]; other site 1225788003400 substrate interface [chemical binding]; other site 1225788003401 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1225788003402 dimer interface [polypeptide binding]; other site 1225788003403 substrate binding site [chemical binding]; other site 1225788003404 ATP binding site [chemical binding]; other site 1225788003405 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1225788003406 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1225788003407 NAD binding site [chemical binding]; other site 1225788003408 homotetramer interface [polypeptide binding]; other site 1225788003409 homodimer interface [polypeptide binding]; other site 1225788003410 substrate binding site [chemical binding]; other site 1225788003411 active site 1225788003412 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1225788003413 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1225788003414 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1225788003415 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1225788003416 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1225788003417 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1225788003418 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1225788003419 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1225788003420 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1225788003421 Part of AAA domain; Region: AAA_19; pfam13245 1225788003422 Family description; Region: UvrD_C_2; pfam13538 1225788003423 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1225788003424 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1225788003425 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1225788003426 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1225788003427 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1225788003428 Walker A/P-loop; other site 1225788003429 ATP binding site [chemical binding]; other site 1225788003430 Q-loop/lid; other site 1225788003431 ABC transporter signature motif; other site 1225788003432 Walker B; other site 1225788003433 D-loop; other site 1225788003434 H-loop/switch region; other site 1225788003435 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1225788003436 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1225788003437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1225788003438 Coenzyme A binding pocket [chemical binding]; other site 1225788003439 hypothetical protein; Provisional; Region: PRK13679 1225788003440 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1225788003441 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1225788003442 Putative esterase; Region: Esterase; pfam00756 1225788003443 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1225788003444 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1225788003445 homodimer interface [polypeptide binding]; other site 1225788003446 substrate-cofactor binding pocket; other site 1225788003447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788003448 catalytic residue [active] 1225788003449 cystathionine beta-lyase; Provisional; Region: PRK08064 1225788003450 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1225788003451 homodimer interface [polypeptide binding]; other site 1225788003452 substrate-cofactor binding pocket; other site 1225788003453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788003454 catalytic residue [active] 1225788003455 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1225788003456 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1225788003457 Int/Topo IB signature motif; other site 1225788003458 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1225788003459 Short C-terminal domain; Region: SHOCT; pfam09851 1225788003460 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1225788003461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788003462 non-specific DNA binding site [nucleotide binding]; other site 1225788003463 salt bridge; other site 1225788003464 sequence-specific DNA binding site [nucleotide binding]; other site 1225788003465 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1225788003466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788003467 non-specific DNA binding site [nucleotide binding]; other site 1225788003468 salt bridge; other site 1225788003469 sequence-specific DNA binding site [nucleotide binding]; other site 1225788003470 Helix-turn-helix domain; Region: HTH_17; pfam12728 1225788003471 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1225788003472 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1225788003473 Helix-turn-helix; Region: HTH_3; pfam01381 1225788003474 non-specific DNA binding site [nucleotide binding]; other site 1225788003475 salt bridge; other site 1225788003476 sequence-specific DNA binding site [nucleotide binding]; other site 1225788003477 Hypothetical protein Yqai; Region: Yqai; pfam09466 1225788003478 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 1225788003479 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1225788003480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788003481 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1225788003482 Walker A motif; other site 1225788003483 ATP binding site [chemical binding]; other site 1225788003484 Walker B motif; other site 1225788003485 arginine finger; other site 1225788003486 YopX protein; Region: YopX; pfam09643 1225788003487 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1225788003488 urease subunit beta; Provisional; Region: ureB; PRK13985 1225788003489 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1225788003490 cofactor binding site; other site 1225788003491 DNA binding site [nucleotide binding] 1225788003492 substrate interaction site [chemical binding]; other site 1225788003493 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1225788003494 positive control sigma-like factor; Validated; Region: PRK06930 1225788003495 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1225788003496 DNA binding residues [nucleotide binding] 1225788003497 Helix-turn-helix domain; Region: HTH_17; pfam12728 1225788003498 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 1225788003499 Domain of unknown function (DUF4393); Region: DUF4393; pfam14337 1225788003500 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1225788003501 Phage terminase large subunit; Region: Terminase_3; cl12054 1225788003502 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1225788003503 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1225788003504 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1225788003505 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 1225788003506 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 1225788003507 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1225788003508 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1225788003509 Phage major tail protein 2; Region: Phage_tail_2; cl11463 1225788003510 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1225788003511 Interdomain contacts; other site 1225788003512 Cytokine receptor motif; other site 1225788003513 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1225788003514 Interdomain contacts; other site 1225788003515 Cytokine receptor motif; other site 1225788003516 Phage protein; Region: DUF3647; pfam12363 1225788003517 membrane protein P6; Region: PHA01399 1225788003518 membrane protein P6; Region: PHA01399 1225788003519 Phage tail protein; Region: Sipho_tail; pfam05709 1225788003520 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1225788003521 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1225788003522 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1225788003523 amidase catalytic site [active] 1225788003524 Zn binding residues [ion binding]; other site 1225788003525 substrate binding site [chemical binding]; other site 1225788003526 Bacterial SH3 domain; Region: SH3_3; cl17532 1225788003527 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1225788003528 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1225788003529 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1225788003530 LXG domain of WXG superfamily; Region: LXG; pfam04740 1225788003531 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1225788003532 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1225788003533 active site 1225788003534 metal binding site [ion binding]; metal-binding site 1225788003535 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1225788003536 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1225788003537 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1225788003538 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788003539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788003540 putative substrate translocation pore; other site 1225788003541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788003542 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1225788003543 putative Zn2+ binding site [ion binding]; other site 1225788003544 putative DNA binding site [nucleotide binding]; other site 1225788003545 dimerization interface [polypeptide binding]; other site 1225788003546 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1225788003547 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1225788003548 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1225788003549 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1225788003550 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1225788003551 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1225788003552 NAD binding site [chemical binding]; other site 1225788003553 homodimer interface [polypeptide binding]; other site 1225788003554 active site 1225788003555 substrate binding site [chemical binding]; other site 1225788003556 galactokinase; Provisional; Region: PRK05322 1225788003557 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1225788003558 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1225788003559 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1225788003560 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1225788003561 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1225788003562 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 1225788003563 active site 1225788003564 P-loop; other site 1225788003565 phosphorylation site [posttranslational modification] 1225788003566 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1225788003567 methionine cluster; other site 1225788003568 active site 1225788003569 phosphorylation site [posttranslational modification] 1225788003570 metal binding site [ion binding]; metal-binding site 1225788003571 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1225788003572 beta-galactosidase; Region: BGL; TIGR03356 1225788003573 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1225788003574 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1225788003575 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1225788003576 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1225788003577 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788003578 motif II; other site 1225788003579 hypothetical protein; Provisional; Region: PRK09272 1225788003580 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788003581 MarR family; Region: MarR; pfam01047 1225788003582 MgtC family; Region: MgtC; pfam02308 1225788003583 Putative motility protein; Region: YjfB_motility; pfam14070 1225788003584 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1225788003585 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1225788003586 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1225788003587 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1225788003588 catalytic loop [active] 1225788003589 iron binding site [ion binding]; other site 1225788003590 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 1225788003591 4Fe-4S binding domain; Region: Fer4; pfam00037 1225788003592 4Fe-4S binding domain; Region: Fer4; pfam00037 1225788003593 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1225788003594 [4Fe-4S] binding site [ion binding]; other site 1225788003595 molybdopterin cofactor binding site; other site 1225788003596 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1225788003597 molybdopterin cofactor binding site; other site 1225788003598 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1225788003599 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1225788003600 Cytochrome P450; Region: p450; cl12078 1225788003601 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1225788003602 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1225788003603 active site 1225788003604 TDP-binding site; other site 1225788003605 acceptor substrate-binding pocket; other site 1225788003606 homodimer interface [polypeptide binding]; other site 1225788003607 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1225788003608 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1225788003609 active site 1225788003610 TIGR00245 family protein; Region: TIGR00245 1225788003611 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1225788003612 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1225788003613 Walker A/P-loop; other site 1225788003614 ATP binding site [chemical binding]; other site 1225788003615 Q-loop/lid; other site 1225788003616 ABC transporter signature motif; other site 1225788003617 Walker B; other site 1225788003618 D-loop; other site 1225788003619 H-loop/switch region; other site 1225788003620 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1225788003621 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1225788003622 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1225788003623 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1225788003624 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1225788003625 Glucuronate isomerase; Region: UxaC; pfam02614 1225788003626 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1225788003627 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1225788003628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788003629 putative substrate translocation pore; other site 1225788003630 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1225788003631 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1225788003632 DNA binding site [nucleotide binding] 1225788003633 domain linker motif; other site 1225788003634 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1225788003635 dimerization interface [polypeptide binding]; other site 1225788003636 ligand binding site [chemical binding]; other site 1225788003637 altronate oxidoreductase; Provisional; Region: PRK03643 1225788003638 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1225788003639 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1225788003640 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1225788003641 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1225788003642 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1225788003643 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1225788003644 DinB family; Region: DinB; cl17821 1225788003645 DinB superfamily; Region: DinB_2; pfam12867 1225788003646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788003647 binding surface 1225788003648 TPR motif; other site 1225788003649 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788003650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1225788003651 binding surface 1225788003652 TPR motif; other site 1225788003653 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1225788003654 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1225788003655 amidase catalytic site [active] 1225788003656 Zn binding residues [ion binding]; other site 1225788003657 substrate binding site [chemical binding]; other site 1225788003658 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1225788003659 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788003660 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1225788003661 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1225788003662 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1225788003663 pentamer interface [polypeptide binding]; other site 1225788003664 dodecaamer interface [polypeptide binding]; other site 1225788003665 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1225788003666 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1225788003667 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1225788003668 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788003669 non-specific DNA binding site [nucleotide binding]; other site 1225788003670 salt bridge; other site 1225788003671 sequence-specific DNA binding site [nucleotide binding]; other site 1225788003672 hypothetical protein; Provisional; Region: PRK06921 1225788003673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788003674 Walker A motif; other site 1225788003675 ATP binding site [chemical binding]; other site 1225788003676 Walker B motif; other site 1225788003677 positive control sigma-like factor; Validated; Region: PRK06930 1225788003678 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1225788003679 DNA binding residues [nucleotide binding] 1225788003680 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1225788003681 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1225788003682 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 1225788003683 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 1225788003684 Phage capsid family; Region: Phage_capsid; pfam05065 1225788003685 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1225788003686 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1225788003687 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1225788003688 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1225788003689 Phage XkdN-like protein; Region: XkdN; pfam08890 1225788003690 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1225788003691 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1225788003692 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1225788003693 catalytic residue [active] 1225788003694 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1225788003695 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788003696 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1225788003697 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1225788003698 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1225788003699 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1225788003700 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1225788003701 Haemolysin XhlA; Region: XhlA; pfam10779 1225788003702 Phage lysis protein, holin; Region: Phage_holin; pfam04688 1225788003703 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1225788003704 amidase catalytic site [active] 1225788003705 Zn binding residues [ion binding]; other site 1225788003706 substrate binding site [chemical binding]; other site 1225788003707 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788003708 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1225788003709 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1225788003710 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1225788003711 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1225788003712 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1225788003713 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1225788003714 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1225788003715 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1225788003716 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1225788003717 Zn binding site [ion binding]; other site 1225788003718 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1225788003719 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1225788003720 Zn binding site [ion binding]; other site 1225788003721 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1225788003722 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1225788003723 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1225788003724 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1225788003725 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1225788003726 Ligand binding site; other site 1225788003727 Putative Catalytic site; other site 1225788003728 DXD motif; other site 1225788003729 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1225788003730 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1225788003731 protein binding site [polypeptide binding]; other site 1225788003732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788003733 putative substrate translocation pore; other site 1225788003734 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1225788003735 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1225788003736 SxDxEG motif; other site 1225788003737 active site 1225788003738 metal binding site [ion binding]; metal-binding site 1225788003739 homopentamer interface [polypeptide binding]; other site 1225788003740 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1225788003741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788003742 dimer interface [polypeptide binding]; other site 1225788003743 conserved gate region; other site 1225788003744 putative PBP binding loops; other site 1225788003745 ABC-ATPase subunit interface; other site 1225788003746 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1225788003747 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1225788003748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788003749 dimer interface [polypeptide binding]; other site 1225788003750 conserved gate region; other site 1225788003751 putative PBP binding loops; other site 1225788003752 ABC-ATPase subunit interface; other site 1225788003753 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1225788003754 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1225788003755 Walker A/P-loop; other site 1225788003756 ATP binding site [chemical binding]; other site 1225788003757 Q-loop/lid; other site 1225788003758 ABC transporter signature motif; other site 1225788003759 Walker B; other site 1225788003760 D-loop; other site 1225788003761 H-loop/switch region; other site 1225788003762 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1225788003763 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1225788003764 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1225788003765 peptide binding site [polypeptide binding]; other site 1225788003766 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1225788003767 dimer interface [polypeptide binding]; other site 1225788003768 catalytic triad [active] 1225788003769 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1225788003770 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1225788003771 active site 1225788003772 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1225788003773 NlpC/P60 family; Region: NLPC_P60; pfam00877 1225788003774 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1225788003775 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1225788003776 Walker A/P-loop; other site 1225788003777 ATP binding site [chemical binding]; other site 1225788003778 Q-loop/lid; other site 1225788003779 ABC transporter signature motif; other site 1225788003780 Walker B; other site 1225788003781 D-loop; other site 1225788003782 H-loop/switch region; other site 1225788003783 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1225788003784 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1225788003785 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1225788003786 Amidinotransferase; Region: Amidinotransf; pfam02274 1225788003787 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1225788003788 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1225788003789 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1225788003790 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1225788003791 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1225788003792 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1225788003793 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1225788003794 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1225788003795 putative active site [active] 1225788003796 putative substrate binding site [chemical binding]; other site 1225788003797 putative cosubstrate binding site; other site 1225788003798 catalytic site [active] 1225788003799 gamma-glutamyl kinase; Provisional; Region: PRK05429 1225788003800 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1225788003801 nucleotide binding site [chemical binding]; other site 1225788003802 homotetrameric interface [polypeptide binding]; other site 1225788003803 putative phosphate binding site [ion binding]; other site 1225788003804 putative allosteric binding site; other site 1225788003805 PUA domain; Region: PUA; pfam01472 1225788003806 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1225788003807 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1225788003808 putative catalytic cysteine [active] 1225788003809 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1225788003810 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1225788003811 MarR family; Region: MarR; pfam01047 1225788003812 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1225788003813 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1225788003814 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1225788003815 putative metal binding site; other site 1225788003816 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1225788003817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788003818 binding surface 1225788003819 TPR motif; other site 1225788003820 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1225788003821 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1225788003822 potential frameshift: common BLAST hit: gi|154685736|ref|YP_001420897.1| DNA-binding transcriptional activator YeiL 1225788003823 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1225788003824 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1225788003825 THF binding site; other site 1225788003826 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1225788003827 substrate binding site [chemical binding]; other site 1225788003828 THF binding site; other site 1225788003829 zinc-binding site [ion binding]; other site 1225788003830 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1225788003831 active site 1225788003832 catalytic residues [active] 1225788003833 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1225788003834 Cobalt transport protein; Region: CbiQ; pfam02361 1225788003835 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1225788003836 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1225788003837 Walker A/P-loop; other site 1225788003838 ATP binding site [chemical binding]; other site 1225788003839 Q-loop/lid; other site 1225788003840 ABC transporter signature motif; other site 1225788003841 Walker B; other site 1225788003842 D-loop; other site 1225788003843 H-loop/switch region; other site 1225788003844 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1225788003845 Walker A/P-loop; other site 1225788003846 ATP binding site [chemical binding]; other site 1225788003847 Q-loop/lid; other site 1225788003848 ABC transporter signature motif; other site 1225788003849 Walker B; other site 1225788003850 D-loop; other site 1225788003851 H-loop/switch region; other site 1225788003852 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1225788003853 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1225788003854 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788003855 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788003856 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1225788003857 active site 1225788003858 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1225788003859 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1225788003860 MgtE intracellular N domain; Region: MgtE_N; smart00924 1225788003861 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1225788003862 Divalent cation transporter; Region: MgtE; pfam01769 1225788003863 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1225788003864 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1225788003865 DNA binding residues [nucleotide binding] 1225788003866 putative dimer interface [polypeptide binding]; other site 1225788003867 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788003868 MarR family; Region: MarR; pfam01047 1225788003869 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1225788003870 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1225788003871 active site 1225788003872 DNA binding site [nucleotide binding] 1225788003873 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1225788003874 nucleotide binding site [chemical binding]; other site 1225788003875 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1225788003876 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1225788003877 putative DNA binding site [nucleotide binding]; other site 1225788003878 putative homodimer interface [polypeptide binding]; other site 1225788003879 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1225788003880 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1225788003881 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1225788003882 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1225788003883 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1225788003884 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1225788003885 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1225788003886 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1225788003887 heat shock protein HtpX; Provisional; Region: PRK05457 1225788003888 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1225788003889 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1225788003890 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1225788003891 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1225788003892 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1225788003893 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1225788003894 putative active site [active] 1225788003895 heme pocket [chemical binding]; other site 1225788003896 PAS domain; Region: PAS; smart00091 1225788003897 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1225788003898 PAS domain; Region: PAS; smart00091 1225788003899 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1225788003900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788003901 dimer interface [polypeptide binding]; other site 1225788003902 phosphorylation site [posttranslational modification] 1225788003903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788003904 ATP binding site [chemical binding]; other site 1225788003905 Mg2+ binding site [ion binding]; other site 1225788003906 G-X-G motif; other site 1225788003907 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1225788003908 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1225788003909 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1225788003910 DNA binding site [nucleotide binding] 1225788003911 active site 1225788003912 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1225788003913 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1225788003914 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1225788003915 Phosphotransferase enzyme family; Region: APH; pfam01636 1225788003916 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1225788003917 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1225788003918 putative active site [active] 1225788003919 catalytic triad [active] 1225788003920 putative dimer interface [polypeptide binding]; other site 1225788003921 transaminase; Reviewed; Region: PRK08068 1225788003922 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1225788003923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788003924 homodimer interface [polypeptide binding]; other site 1225788003925 catalytic residue [active] 1225788003926 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1225788003927 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1225788003928 dimer interface [polypeptide binding]; other site 1225788003929 active site 1225788003930 catalytic residue [active] 1225788003931 metal binding site [ion binding]; metal-binding site 1225788003932 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1225788003933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788003934 motif II; other site 1225788003935 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1225788003936 intersubunit interface [polypeptide binding]; other site 1225788003937 active site 1225788003938 Zn2+ binding site [ion binding]; other site 1225788003939 ARD/ARD' family; Region: ARD; pfam03079 1225788003940 Cupin domain; Region: Cupin_2; pfam07883 1225788003941 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1225788003942 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788003943 dimer interface [polypeptide binding]; other site 1225788003944 phosphorylation site [posttranslational modification] 1225788003945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788003946 ATP binding site [chemical binding]; other site 1225788003947 Mg2+ binding site [ion binding]; other site 1225788003948 G-X-G motif; other site 1225788003949 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788003950 MarR family; Region: MarR; pfam01047 1225788003951 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1225788003952 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1225788003953 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1225788003954 ligand binding site [chemical binding]; other site 1225788003955 flagellar motor protein MotA; Validated; Region: PRK08124 1225788003956 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1225788003957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788003958 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1225788003959 Walker A motif; other site 1225788003960 ATP binding site [chemical binding]; other site 1225788003961 Walker B motif; other site 1225788003962 arginine finger; other site 1225788003963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788003964 Walker A motif; other site 1225788003965 ATP binding site [chemical binding]; other site 1225788003966 Walker B motif; other site 1225788003967 arginine finger; other site 1225788003968 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1225788003969 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1225788003970 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1225788003971 Ligand Binding Site [chemical binding]; other site 1225788003972 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 1225788003973 active site 1225788003974 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1225788003975 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1225788003976 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1225788003977 Predicted transcriptional regulators [Transcription]; Region: COG1733 1225788003978 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1225788003979 short chain dehydrogenase; Provisional; Region: PRK06500 1225788003980 classical (c) SDRs; Region: SDR_c; cd05233 1225788003981 NAD(P) binding site [chemical binding]; other site 1225788003982 active site 1225788003983 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1225788003984 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1225788003985 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1225788003986 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1225788003987 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1225788003988 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1225788003989 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1225788003990 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1225788003991 catalytic residues [active] 1225788003992 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1225788003993 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1225788003994 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1225788003995 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1225788003996 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1225788003997 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1225788003998 active site 1225788003999 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1225788004000 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1225788004001 DNA binding site [nucleotide binding] 1225788004002 domain linker motif; other site 1225788004003 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1225788004004 putative dimerization interface [polypeptide binding]; other site 1225788004005 putative ligand binding site [chemical binding]; other site 1225788004006 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1225788004007 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1225788004008 PRD domain; Region: PRD; pfam00874 1225788004009 PRD domain; Region: PRD; pfam00874 1225788004010 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1225788004011 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1225788004012 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1225788004013 active site turn [active] 1225788004014 phosphorylation site [posttranslational modification] 1225788004015 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1225788004016 HPr interaction site; other site 1225788004017 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1225788004018 active site 1225788004019 phosphorylation site [posttranslational modification] 1225788004020 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1225788004021 dimerization domain swap beta strand [polypeptide binding]; other site 1225788004022 regulatory protein interface [polypeptide binding]; other site 1225788004023 active site 1225788004024 regulatory phosphorylation site [posttranslational modification]; other site 1225788004025 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1225788004026 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1225788004027 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1225788004028 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1225788004029 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1225788004030 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1225788004031 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1225788004032 FeS/SAM binding site; other site 1225788004033 Cache domain; Region: Cache_1; pfam02743 1225788004034 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1225788004035 dimerization interface [polypeptide binding]; other site 1225788004036 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1225788004037 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1225788004038 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1225788004039 dimer interface [polypeptide binding]; other site 1225788004040 putative CheW interface [polypeptide binding]; other site 1225788004041 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1225788004042 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1225788004043 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1225788004044 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1225788004045 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1225788004046 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1225788004047 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1225788004048 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1225788004049 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1225788004050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1225788004051 putative active site [active] 1225788004052 heme pocket [chemical binding]; other site 1225788004053 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1225788004054 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1225788004055 putative active site [active] 1225788004056 heme pocket [chemical binding]; other site 1225788004057 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1225788004058 putative active site [active] 1225788004059 heme pocket [chemical binding]; other site 1225788004060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788004061 dimer interface [polypeptide binding]; other site 1225788004062 phosphorylation site [posttranslational modification] 1225788004063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788004064 ATP binding site [chemical binding]; other site 1225788004065 Mg2+ binding site [ion binding]; other site 1225788004066 G-X-G motif; other site 1225788004067 aminotransferase A; Validated; Region: PRK07683 1225788004068 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1225788004069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788004070 homodimer interface [polypeptide binding]; other site 1225788004071 catalytic residue [active] 1225788004072 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1225788004073 putative CheA interaction surface; other site 1225788004074 Response regulator receiver domain; Region: Response_reg; pfam00072 1225788004075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788004076 active site 1225788004077 phosphorylation site [posttranslational modification] 1225788004078 intermolecular recognition site; other site 1225788004079 dimerization interface [polypeptide binding]; other site 1225788004080 YkyB-like protein; Region: YkyB; pfam14177 1225788004081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788004082 H+ Antiporter protein; Region: 2A0121; TIGR00900 1225788004083 putative substrate translocation pore; other site 1225788004084 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788004085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1225788004086 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1225788004087 phosphodiesterase YaeI; Provisional; Region: PRK11340 1225788004088 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1225788004089 putative active site [active] 1225788004090 putative metal binding site [ion binding]; other site 1225788004091 short chain dehydrogenase; Provisional; Region: PRK07677 1225788004092 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1225788004093 NAD(P) binding site [chemical binding]; other site 1225788004094 substrate binding site [chemical binding]; other site 1225788004095 homotetramer interface [polypeptide binding]; other site 1225788004096 active site 1225788004097 homodimer interface [polypeptide binding]; other site 1225788004098 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1225788004099 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1225788004100 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1225788004101 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1225788004102 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1225788004103 FOG: CBS domain [General function prediction only]; Region: COG0517 1225788004104 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1225788004105 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788004106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788004107 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1225788004108 dimerization interface [polypeptide binding]; other site 1225788004109 flavodoxin; Provisional; Region: PRK06703 1225788004110 BNR repeat-like domain; Region: BNR_2; pfam13088 1225788004111 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1225788004112 flavodoxin, short chain; Region: flav_short; TIGR01753 1225788004113 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1225788004114 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1225788004115 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1225788004116 active site 1225788004117 trimer interface [polypeptide binding]; other site 1225788004118 substrate binding site [chemical binding]; other site 1225788004119 CoA binding site [chemical binding]; other site 1225788004120 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1225788004121 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1225788004122 metal binding site [ion binding]; metal-binding site 1225788004123 hypothetical protein; Provisional; Region: PRK03094 1225788004124 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1225788004125 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1225788004126 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1225788004127 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1225788004128 catalytic residues [active] 1225788004129 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1225788004130 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1225788004131 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1225788004132 GTP binding site; other site 1225788004133 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1225788004134 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1225788004135 ATP binding site [chemical binding]; other site 1225788004136 substrate interface [chemical binding]; other site 1225788004137 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1225788004138 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1225788004139 dimer interface [polypeptide binding]; other site 1225788004140 putative functional site; other site 1225788004141 putative MPT binding site; other site 1225788004142 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1225788004143 Walker A motif; other site 1225788004144 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1225788004145 MoaE homodimer interface [polypeptide binding]; other site 1225788004146 MoaD interaction [polypeptide binding]; other site 1225788004147 active site residues [active] 1225788004148 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1225788004149 MoaE interaction surface [polypeptide binding]; other site 1225788004150 MoeB interaction surface [polypeptide binding]; other site 1225788004151 thiocarboxylated glycine; other site 1225788004152 Yip1 domain; Region: Yip1; pfam04893 1225788004153 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1225788004154 HlyD family secretion protein; Region: HlyD_3; pfam13437 1225788004155 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1225788004156 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1225788004157 Walker A/P-loop; other site 1225788004158 ATP binding site [chemical binding]; other site 1225788004159 Q-loop/lid; other site 1225788004160 ABC transporter signature motif; other site 1225788004161 Walker B; other site 1225788004162 D-loop; other site 1225788004163 H-loop/switch region; other site 1225788004164 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1225788004165 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1225788004166 FtsX-like permease family; Region: FtsX; pfam02687 1225788004167 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1225788004168 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1225788004169 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1225788004170 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1225788004171 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1225788004172 putative substrate binding site [chemical binding]; other site 1225788004173 putative ATP binding site [chemical binding]; other site 1225788004174 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1225788004175 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1225788004176 active site 1225788004177 phosphorylation site [posttranslational modification] 1225788004178 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1225788004179 active site 1225788004180 P-loop; other site 1225788004181 phosphorylation site [posttranslational modification] 1225788004182 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1225788004183 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1225788004184 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1225788004185 Catalytic site [active] 1225788004186 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1225788004187 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1225788004188 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1225788004189 ABC transporter; Region: ABC_tran_2; pfam12848 1225788004190 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1225788004191 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1225788004192 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1225788004193 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1225788004194 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1225788004195 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1225788004196 rod-share determining protein MreBH; Provisional; Region: PRK13929 1225788004197 MreB and similar proteins; Region: MreB_like; cd10225 1225788004198 nucleotide binding site [chemical binding]; other site 1225788004199 Mg binding site [ion binding]; other site 1225788004200 putative protofilament interaction site [polypeptide binding]; other site 1225788004201 RodZ interaction site [polypeptide binding]; other site 1225788004202 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1225788004203 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1225788004204 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1225788004205 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1225788004206 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1225788004207 putative active site [active] 1225788004208 heme pocket [chemical binding]; other site 1225788004209 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788004210 dimer interface [polypeptide binding]; other site 1225788004211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788004212 ATP binding site [chemical binding]; other site 1225788004213 Mg2+ binding site [ion binding]; other site 1225788004214 G-X-G motif; other site 1225788004215 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1225788004216 putative active site pocket [active] 1225788004217 dimerization interface [polypeptide binding]; other site 1225788004218 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1225788004219 putative active site pocket [active] 1225788004220 dimerization interface [polypeptide binding]; other site 1225788004221 putative catalytic residue [active] 1225788004222 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1225788004223 TrkA-N domain; Region: TrkA_N; pfam02254 1225788004224 TrkA-C domain; Region: TrkA_C; pfam02080 1225788004225 adenine deaminase; Region: ade; TIGR01178 1225788004226 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1225788004227 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1225788004228 active site 1225788004229 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1225788004230 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1225788004231 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1225788004232 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1225788004233 hypothetical protein; Provisional; Region: PRK13667 1225788004234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788004235 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1225788004236 active site 1225788004237 motif I; other site 1225788004238 motif II; other site 1225788004239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788004240 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1225788004241 active site 1225788004242 catalytic residues [active] 1225788004243 metal binding site [ion binding]; metal-binding site 1225788004244 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1225788004245 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1225788004246 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1225788004247 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1225788004248 FMN binding site [chemical binding]; other site 1225788004249 substrate binding site [chemical binding]; other site 1225788004250 putative catalytic residue [active] 1225788004251 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788004252 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788004253 active site 1225788004254 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788004255 KR domain; Region: KR; pfam08659 1225788004256 putative NADP binding site [chemical binding]; other site 1225788004257 active site 1225788004258 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788004259 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788004260 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788004261 active site 1225788004262 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788004263 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788004264 putative NADP binding site [chemical binding]; other site 1225788004265 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788004266 active site 1225788004267 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788004268 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788004269 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1225788004270 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788004271 active site 1225788004272 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788004273 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788004274 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788004275 putative NADP binding site [chemical binding]; other site 1225788004276 active site 1225788004277 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788004278 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788004279 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788004280 active site 1225788004281 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788004282 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788004283 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788004284 putative NADP binding site [chemical binding]; other site 1225788004285 active site 1225788004286 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788004287 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788004288 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788004289 active site 1225788004290 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788004291 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788004292 putative NADP binding site [chemical binding]; other site 1225788004293 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788004294 active site 1225788004295 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788004296 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788004297 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1225788004298 active site 1225788004299 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788004300 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788004301 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788004302 putative NADP binding site [chemical binding]; other site 1225788004303 active site 1225788004304 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788004305 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788004306 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788004307 active site 1225788004308 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788004309 putative NADP binding site [chemical binding]; other site 1225788004310 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788004311 active site 1225788004312 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788004313 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788004314 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788004315 active site 1225788004316 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788004317 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788004318 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788004319 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788004320 putative NADP binding site [chemical binding]; other site 1225788004321 active site 1225788004322 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788004323 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788004324 active site 1225788004325 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788004326 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788004327 putative NADP binding site [chemical binding]; other site 1225788004328 KR domain; Region: KR; pfam08659 1225788004329 active site 1225788004330 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788004331 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788004332 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788004333 active site 1225788004334 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788004335 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788004336 putative NADP binding site [chemical binding]; other site 1225788004337 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788004338 active site 1225788004339 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788004340 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788004341 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788004342 active site 1225788004343 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788004344 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788004345 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788004346 putative NADP binding site [chemical binding]; other site 1225788004347 KR domain; Region: KR; pfam08659 1225788004348 active site 1225788004349 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1225788004350 Beta-lactamase; Region: Beta-lactamase; pfam00144 1225788004351 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1225788004352 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1225788004353 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1225788004354 TPP-binding site [chemical binding]; other site 1225788004355 tetramer interface [polypeptide binding]; other site 1225788004356 heterodimer interface [polypeptide binding]; other site 1225788004357 phosphorylation loop region [posttranslational modification] 1225788004358 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1225788004359 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1225788004360 alpha subunit interface [polypeptide binding]; other site 1225788004361 TPP binding site [chemical binding]; other site 1225788004362 heterodimer interface [polypeptide binding]; other site 1225788004363 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1225788004364 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1225788004365 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1225788004366 E3 interaction surface; other site 1225788004367 lipoyl attachment site [posttranslational modification]; other site 1225788004368 e3 binding domain; Region: E3_binding; pfam02817 1225788004369 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1225788004370 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1225788004371 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1225788004372 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1225788004373 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1225788004374 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1225788004375 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1225788004376 NodB motif; other site 1225788004377 active site 1225788004378 catalytic site [active] 1225788004379 metal binding site [ion binding]; metal-binding site 1225788004380 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1225788004381 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1225788004382 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1225788004383 homodimer interface [polypeptide binding]; other site 1225788004384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788004385 catalytic residue [active] 1225788004386 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1225788004387 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1225788004388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1225788004389 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1225788004390 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1225788004391 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1225788004392 active site 1225788004393 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1225788004394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788004395 Coenzyme A binding pocket [chemical binding]; other site 1225788004396 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1225788004397 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1225788004398 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1225788004399 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1225788004400 active site 1225788004401 Zn binding site [ion binding]; other site 1225788004402 Putative zinc-finger; Region: zf-HC2; pfam13490 1225788004403 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1225788004404 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1225788004405 G1 box; other site 1225788004406 putative GEF interaction site [polypeptide binding]; other site 1225788004407 GTP/Mg2+ binding site [chemical binding]; other site 1225788004408 Switch I region; other site 1225788004409 G2 box; other site 1225788004410 G3 box; other site 1225788004411 Switch II region; other site 1225788004412 G4 box; other site 1225788004413 G5 box; other site 1225788004414 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1225788004415 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1225788004416 YlaH-like protein; Region: YlaH; pfam14036 1225788004417 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1225788004418 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1225788004419 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1225788004420 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1225788004421 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1225788004422 putative active site [active] 1225788004423 PhoH-like protein; Region: PhoH; pfam02562 1225788004424 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1225788004425 glutaminase A; Region: Gln_ase; TIGR03814 1225788004426 hypothetical protein; Provisional; Region: PRK13666 1225788004427 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1225788004428 pyruvate carboxylase; Reviewed; Region: PRK12999 1225788004429 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1225788004430 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1225788004431 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1225788004432 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1225788004433 active site 1225788004434 catalytic residues [active] 1225788004435 metal binding site [ion binding]; metal-binding site 1225788004436 homodimer binding site [polypeptide binding]; other site 1225788004437 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1225788004438 carboxyltransferase (CT) interaction site; other site 1225788004439 biotinylation site [posttranslational modification]; other site 1225788004440 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1225788004441 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1225788004442 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1225788004443 UbiA prenyltransferase family; Region: UbiA; pfam01040 1225788004444 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1225788004445 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1225788004446 Cytochrome c; Region: Cytochrom_C; pfam00034 1225788004447 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1225788004448 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1225788004449 D-pathway; other site 1225788004450 Putative ubiquinol binding site [chemical binding]; other site 1225788004451 Low-spin heme (heme b) binding site [chemical binding]; other site 1225788004452 Putative water exit pathway; other site 1225788004453 Binuclear center (heme o3/CuB) [ion binding]; other site 1225788004454 K-pathway; other site 1225788004455 Putative proton exit pathway; other site 1225788004456 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1225788004457 Subunit I/III interface [polypeptide binding]; other site 1225788004458 Subunit III/IV interface [polypeptide binding]; other site 1225788004459 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 1225788004460 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1225788004461 YugN-like family; Region: YugN; pfam08868 1225788004462 FOG: CBS domain [General function prediction only]; Region: COG0517 1225788004463 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1225788004464 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1225788004465 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1225788004466 Putative coat protein; Region: YlbD_coat; pfam14071 1225788004467 YlbE-like protein; Region: YlbE; pfam14003 1225788004468 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1225788004469 hypothetical protein; Provisional; Region: PRK02886 1225788004470 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1225788004471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788004472 S-adenosylmethionine binding site [chemical binding]; other site 1225788004473 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1225788004474 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1225788004475 active site 1225788004476 (T/H)XGH motif; other site 1225788004477 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1225788004478 Nucleoside recognition; Region: Gate; pfam07670 1225788004479 Nucleoside recognition; Region: Gate; pfam07670 1225788004480 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1225788004481 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1225788004482 active site 1225788004483 nucleophile elbow; other site 1225788004484 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1225788004485 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1225788004486 protein binding site [polypeptide binding]; other site 1225788004487 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1225788004488 hypothetical protein; Provisional; Region: PRK13670 1225788004489 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1225788004490 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1225788004491 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1225788004492 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1225788004493 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1225788004494 hypothetical protein; Provisional; Region: PRK13688 1225788004495 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788004496 Coenzyme A binding pocket [chemical binding]; other site 1225788004497 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1225788004498 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1225788004499 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1225788004500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1225788004501 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 1225788004502 mraZ protein; Region: TIGR00242 1225788004503 MraZ protein; Region: MraZ; pfam02381 1225788004504 MraZ protein; Region: MraZ; pfam02381 1225788004505 MraW methylase family; Region: Methyltransf_5; pfam01795 1225788004506 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1225788004507 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1225788004508 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1225788004509 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1225788004510 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1225788004511 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1225788004512 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1225788004513 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1225788004514 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1225788004515 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1225788004516 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1225788004517 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1225788004518 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1225788004519 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1225788004520 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1225788004521 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1225788004522 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1225788004523 Mg++ binding site [ion binding]; other site 1225788004524 putative catalytic motif [active] 1225788004525 putative substrate binding site [chemical binding]; other site 1225788004526 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1225788004527 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1225788004528 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1225788004529 stage V sporulation protein E; Region: spoVE; TIGR02615 1225788004530 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1225788004531 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1225788004532 active site 1225788004533 homodimer interface [polypeptide binding]; other site 1225788004534 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1225788004535 FAD binding domain; Region: FAD_binding_4; pfam01565 1225788004536 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1225788004537 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1225788004538 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1225788004539 Cell division protein FtsQ; Region: FtsQ; pfam03799 1225788004540 cell division protein FtsA; Region: ftsA; TIGR01174 1225788004541 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1225788004542 nucleotide binding site [chemical binding]; other site 1225788004543 Cell division protein FtsA; Region: FtsA; pfam14450 1225788004544 cell division protein FtsZ; Validated; Region: PRK09330 1225788004545 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1225788004546 nucleotide binding site [chemical binding]; other site 1225788004547 SulA interaction site; other site 1225788004548 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1225788004549 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1225788004550 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1225788004551 active site 1225788004552 catalytic triad [active] 1225788004553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1225788004554 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1225788004555 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1225788004556 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1225788004557 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1225788004558 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1225788004559 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1225788004560 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1225788004561 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1225788004562 DNA binding residues [nucleotide binding] 1225788004563 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1225788004564 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1225788004565 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1225788004566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1225788004567 DNA binding residues [nucleotide binding] 1225788004568 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1225788004569 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1225788004570 Walker A/P-loop; other site 1225788004571 ATP binding site [chemical binding]; other site 1225788004572 Q-loop/lid; other site 1225788004573 ABC transporter signature motif; other site 1225788004574 Walker B; other site 1225788004575 D-loop; other site 1225788004576 H-loop/switch region; other site 1225788004577 acetylornithine deacetylase; Validated; Region: PRK08596 1225788004578 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1225788004579 metal binding site [ion binding]; metal-binding site 1225788004580 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1225788004581 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1225788004582 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1225788004583 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1225788004584 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1225788004585 catalytic residue [active] 1225788004586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1225788004587 YGGT family; Region: YGGT; pfam02325 1225788004588 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1225788004589 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1225788004590 RNA binding surface [nucleotide binding]; other site 1225788004591 DivIVA protein; Region: DivIVA; pfam05103 1225788004592 DivIVA domain; Region: DivI1A_domain; TIGR03544 1225788004593 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1225788004594 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1225788004595 HIGH motif; other site 1225788004596 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1225788004597 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1225788004598 active site 1225788004599 KMSKS motif; other site 1225788004600 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1225788004601 tRNA binding surface [nucleotide binding]; other site 1225788004602 anticodon binding site; other site 1225788004603 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1225788004604 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1225788004605 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1225788004606 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1225788004607 RNA binding surface [nucleotide binding]; other site 1225788004608 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1225788004609 active site 1225788004610 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1225788004611 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1225788004612 active site 1225788004613 uracil-xanthine permease; Region: ncs2; TIGR00801 1225788004614 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1225788004615 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1225788004616 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1225788004617 dihydroorotase; Validated; Region: pyrC; PRK09357 1225788004618 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1225788004619 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1225788004620 active site 1225788004621 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1225788004622 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1225788004623 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1225788004624 catalytic site [active] 1225788004625 subunit interface [polypeptide binding]; other site 1225788004626 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1225788004627 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1225788004628 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1225788004629 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1225788004630 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1225788004631 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1225788004632 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1225788004633 IMP binding site; other site 1225788004634 dimer interface [polypeptide binding]; other site 1225788004635 interdomain contacts; other site 1225788004636 partial ornithine binding site; other site 1225788004637 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1225788004638 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1225788004639 FAD binding pocket [chemical binding]; other site 1225788004640 FAD binding motif [chemical binding]; other site 1225788004641 phosphate binding motif [ion binding]; other site 1225788004642 beta-alpha-beta structure motif; other site 1225788004643 NAD binding pocket [chemical binding]; other site 1225788004644 Iron coordination center [ion binding]; other site 1225788004645 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1225788004646 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1225788004647 heterodimer interface [polypeptide binding]; other site 1225788004648 active site 1225788004649 FMN binding site [chemical binding]; other site 1225788004650 homodimer interface [polypeptide binding]; other site 1225788004651 substrate binding site [chemical binding]; other site 1225788004652 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1225788004653 active site 1225788004654 dimer interface [polypeptide binding]; other site 1225788004655 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1225788004656 active site 1225788004657 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1225788004658 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1225788004659 Active Sites [active] 1225788004660 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1225788004661 potential frameshift: common BLAST hit: gi|154685975|ref|YP_001421136.1| sulfate adenylyltransferase 1225788004662 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1225788004663 AAA domain; Region: AAA_18; pfam13238 1225788004664 ligand-binding site [chemical binding]; other site 1225788004665 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1225788004666 diphthine synthase; Region: dph5; TIGR00522 1225788004667 active site 1225788004668 SAM binding site [chemical binding]; other site 1225788004669 homodimer interface [polypeptide binding]; other site 1225788004670 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1225788004671 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1225788004672 putative active site [active] 1225788004673 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1225788004674 putative active site [active] 1225788004675 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1225788004676 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1225788004677 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1225788004678 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1225788004679 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1225788004680 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1225788004681 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1225788004682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788004683 motif II; other site 1225788004684 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1225788004685 hypothetical protein; Provisional; Region: PRK11820 1225788004686 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1225788004687 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1225788004688 hypothetical protein; Provisional; Region: PRK04323 1225788004689 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1225788004690 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1225788004691 catalytic site [active] 1225788004692 G-X2-G-X-G-K; other site 1225788004693 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1225788004694 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1225788004695 Flavoprotein; Region: Flavoprotein; pfam02441 1225788004696 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1225788004697 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1225788004698 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1225788004699 ATP binding site [chemical binding]; other site 1225788004700 putative Mg++ binding site [ion binding]; other site 1225788004701 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1225788004702 nucleotide binding region [chemical binding]; other site 1225788004703 ATP-binding site [chemical binding]; other site 1225788004704 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1225788004705 active site 1225788004706 catalytic residues [active] 1225788004707 metal binding site [ion binding]; metal-binding site 1225788004708 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1225788004709 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1225788004710 putative active site [active] 1225788004711 substrate binding site [chemical binding]; other site 1225788004712 putative cosubstrate binding site; other site 1225788004713 catalytic site [active] 1225788004714 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1225788004715 substrate binding site [chemical binding]; other site 1225788004716 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1225788004717 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1225788004718 putative RNA binding site [nucleotide binding]; other site 1225788004719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788004720 S-adenosylmethionine binding site [chemical binding]; other site 1225788004721 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1225788004722 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1225788004723 FeS/SAM binding site; other site 1225788004724 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1225788004725 Protein phosphatase 2C; Region: PP2C; pfam00481 1225788004726 active site 1225788004727 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1225788004728 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1225788004729 active site 1225788004730 ATP binding site [chemical binding]; other site 1225788004731 substrate binding site [chemical binding]; other site 1225788004732 activation loop (A-loop); other site 1225788004733 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1225788004734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1225788004735 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1225788004736 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1225788004737 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1225788004738 GTPase RsgA; Reviewed; Region: PRK00098 1225788004739 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1225788004740 RNA binding site [nucleotide binding]; other site 1225788004741 homodimer interface [polypeptide binding]; other site 1225788004742 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1225788004743 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1225788004744 GTP/Mg2+ binding site [chemical binding]; other site 1225788004745 G4 box; other site 1225788004746 G5 box; other site 1225788004747 G1 box; other site 1225788004748 Switch I region; other site 1225788004749 G2 box; other site 1225788004750 G3 box; other site 1225788004751 Switch II region; other site 1225788004752 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1225788004753 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1225788004754 substrate binding site [chemical binding]; other site 1225788004755 hexamer interface [polypeptide binding]; other site 1225788004756 metal binding site [ion binding]; metal-binding site 1225788004757 Thiamine pyrophosphokinase; Region: TPK; cd07995 1225788004758 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1225788004759 active site 1225788004760 dimerization interface [polypeptide binding]; other site 1225788004761 thiamine binding site [chemical binding]; other site 1225788004762 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 1225788004763 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1225788004764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1225788004765 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1225788004766 DAK2 domain; Region: Dak2; pfam02734 1225788004767 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1225788004768 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1225788004769 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1225788004770 putative L-serine binding site [chemical binding]; other site 1225788004771 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1225788004772 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1225788004773 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1225788004774 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1225788004775 generic binding surface II; other site 1225788004776 ssDNA binding site; other site 1225788004777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1225788004778 ATP binding site [chemical binding]; other site 1225788004779 putative Mg++ binding site [ion binding]; other site 1225788004780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1225788004781 nucleotide binding region [chemical binding]; other site 1225788004782 ATP-binding site [chemical binding]; other site 1225788004783 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1225788004784 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1225788004785 putative phosphate acyltransferase; Provisional; Region: PRK05331 1225788004786 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1225788004787 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1225788004788 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1225788004789 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1225788004790 NAD(P) binding site [chemical binding]; other site 1225788004791 homotetramer interface [polypeptide binding]; other site 1225788004792 homodimer interface [polypeptide binding]; other site 1225788004793 active site 1225788004794 acyl carrier protein; Provisional; Region: acpP; PRK00982 1225788004795 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1225788004796 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1225788004797 dimerization interface [polypeptide binding]; other site 1225788004798 active site 1225788004799 metal binding site [ion binding]; metal-binding site 1225788004800 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1225788004801 dsRNA binding site [nucleotide binding]; other site 1225788004802 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1225788004803 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1225788004804 Walker A/P-loop; other site 1225788004805 ATP binding site [chemical binding]; other site 1225788004806 Q-loop/lid; other site 1225788004807 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1225788004808 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1225788004809 ABC transporter signature motif; other site 1225788004810 Walker B; other site 1225788004811 D-loop; other site 1225788004812 H-loop/switch region; other site 1225788004813 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1225788004814 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1225788004815 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1225788004816 GTP binding site [chemical binding]; other site 1225788004817 Phosphotransferase enzyme family; Region: APH; pfam01636 1225788004818 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1225788004819 active site 1225788004820 ATP binding site [chemical binding]; other site 1225788004821 putative DNA-binding protein; Validated; Region: PRK00118 1225788004822 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1225788004823 signal recognition particle protein; Provisional; Region: PRK10867 1225788004824 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1225788004825 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1225788004826 P loop; other site 1225788004827 GTP binding site [chemical binding]; other site 1225788004828 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1225788004829 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1225788004830 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1225788004831 KH domain; Region: KH_4; pfam13083 1225788004832 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1225788004833 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1225788004834 RimM N-terminal domain; Region: RimM; pfam01782 1225788004835 PRC-barrel domain; Region: PRC; pfam05239 1225788004836 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1225788004837 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1225788004838 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1225788004839 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1225788004840 GTP/Mg2+ binding site [chemical binding]; other site 1225788004841 G4 box; other site 1225788004842 G5 box; other site 1225788004843 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1225788004844 G1 box; other site 1225788004845 G1 box; other site 1225788004846 GTP/Mg2+ binding site [chemical binding]; other site 1225788004847 Switch I region; other site 1225788004848 G2 box; other site 1225788004849 G2 box; other site 1225788004850 G3 box; other site 1225788004851 G3 box; other site 1225788004852 Switch II region; other site 1225788004853 Switch II region; other site 1225788004854 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1225788004855 RNA/DNA hybrid binding site [nucleotide binding]; other site 1225788004856 active site 1225788004857 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1225788004858 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1225788004859 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1225788004860 CoA-ligase; Region: Ligase_CoA; pfam00549 1225788004861 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1225788004862 CoA binding domain; Region: CoA_binding; smart00881 1225788004863 CoA-ligase; Region: Ligase_CoA; pfam00549 1225788004864 DNA protecting protein DprA; Region: dprA; TIGR00732 1225788004865 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1225788004866 DNA topoisomerase I; Validated; Region: PRK05582 1225788004867 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1225788004868 active site 1225788004869 interdomain interaction site; other site 1225788004870 putative metal-binding site [ion binding]; other site 1225788004871 nucleotide binding site [chemical binding]; other site 1225788004872 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1225788004873 domain I; other site 1225788004874 DNA binding groove [nucleotide binding] 1225788004875 phosphate binding site [ion binding]; other site 1225788004876 domain II; other site 1225788004877 domain III; other site 1225788004878 nucleotide binding site [chemical binding]; other site 1225788004879 catalytic site [active] 1225788004880 domain IV; other site 1225788004881 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1225788004882 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1225788004883 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1225788004884 Glucose inhibited division protein A; Region: GIDA; pfam01134 1225788004885 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1225788004886 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1225788004887 active site 1225788004888 Int/Topo IB signature motif; other site 1225788004889 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1225788004890 active site 1225788004891 HslU subunit interaction site [polypeptide binding]; other site 1225788004892 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1225788004893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788004894 Walker A motif; other site 1225788004895 ATP binding site [chemical binding]; other site 1225788004896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1225788004897 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1225788004898 transcriptional repressor CodY; Validated; Region: PRK04158 1225788004899 CodY GAF-like domain; Region: CodY; pfam06018 1225788004900 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1225788004901 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1225788004902 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1225788004903 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1225788004904 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1225788004905 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1225788004906 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1225788004907 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 1225788004908 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1225788004909 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1225788004910 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1225788004911 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1225788004912 MgtE intracellular N domain; Region: MgtE_N; smart00924 1225788004913 FliG C-terminal domain; Region: FliG_C; pfam01706 1225788004914 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 1225788004915 Flagellar assembly protein FliH; Region: FliH; pfam02108 1225788004916 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1225788004917 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1225788004918 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1225788004919 Walker A motif/ATP binding site; other site 1225788004920 Walker B motif; other site 1225788004921 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1225788004922 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1225788004923 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1225788004924 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1225788004925 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1225788004926 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1225788004927 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1225788004928 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1225788004929 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1225788004930 Flagellar protein (FlbD); Region: FlbD; pfam06289 1225788004931 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1225788004932 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1225788004933 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1225788004934 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1225788004935 flagellar motor switch protein; Validated; Region: PRK08119 1225788004936 CheC-like family; Region: CheC; pfam04509 1225788004937 CheC-like family; Region: CheC; pfam04509 1225788004938 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1225788004939 Response regulator receiver domain; Region: Response_reg; pfam00072 1225788004940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788004941 active site 1225788004942 phosphorylation site [posttranslational modification] 1225788004943 intermolecular recognition site; other site 1225788004944 dimerization interface [polypeptide binding]; other site 1225788004945 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 1225788004946 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1225788004947 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1225788004948 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1225788004949 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1225788004950 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1225788004951 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1225788004952 FHIPEP family; Region: FHIPEP; pfam00771 1225788004953 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1225788004954 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1225788004955 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1225788004956 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1225788004957 P-loop; other site 1225788004958 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1225788004959 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1225788004960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788004961 active site 1225788004962 phosphorylation site [posttranslational modification] 1225788004963 intermolecular recognition site; other site 1225788004964 dimerization interface [polypeptide binding]; other site 1225788004965 CheB methylesterase; Region: CheB_methylest; pfam01339 1225788004966 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1225788004967 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1225788004968 putative binding surface; other site 1225788004969 active site 1225788004970 P2 response regulator binding domain; Region: P2; pfam07194 1225788004971 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1225788004972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788004973 ATP binding site [chemical binding]; other site 1225788004974 Mg2+ binding site [ion binding]; other site 1225788004975 G-X-G motif; other site 1225788004976 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1225788004977 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1225788004978 putative CheA interaction surface; other site 1225788004979 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1225788004980 CheC-like family; Region: CheC; pfam04509 1225788004981 CheC-like family; Region: CheC; pfam04509 1225788004982 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1225788004983 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1225788004984 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1225788004985 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1225788004986 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1225788004987 DNA binding residues [nucleotide binding] 1225788004988 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1225788004989 rRNA interaction site [nucleotide binding]; other site 1225788004990 S8 interaction site; other site 1225788004991 putative laminin-1 binding site; other site 1225788004992 elongation factor Ts; Provisional; Region: tsf; PRK09377 1225788004993 UBA/TS-N domain; Region: UBA; pfam00627 1225788004994 Elongation factor TS; Region: EF_TS; pfam00889 1225788004995 Elongation factor TS; Region: EF_TS; pfam00889 1225788004996 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1225788004997 putative nucleotide binding site [chemical binding]; other site 1225788004998 uridine monophosphate binding site [chemical binding]; other site 1225788004999 homohexameric interface [polypeptide binding]; other site 1225788005000 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1225788005001 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1225788005002 hinge region; other site 1225788005003 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1225788005004 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1225788005005 catalytic residue [active] 1225788005006 putative FPP diphosphate binding site; other site 1225788005007 putative FPP binding hydrophobic cleft; other site 1225788005008 dimer interface [polypeptide binding]; other site 1225788005009 putative IPP diphosphate binding site; other site 1225788005010 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1225788005011 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1225788005012 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1225788005013 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1225788005014 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1225788005015 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1225788005016 RIP metalloprotease RseP; Region: TIGR00054 1225788005017 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1225788005018 active site 1225788005019 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1225788005020 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1225788005021 protein binding site [polypeptide binding]; other site 1225788005022 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1225788005023 putative substrate binding region [chemical binding]; other site 1225788005024 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1225788005025 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1225788005026 dimer interface [polypeptide binding]; other site 1225788005027 motif 1; other site 1225788005028 active site 1225788005029 motif 2; other site 1225788005030 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1225788005031 putative deacylase active site [active] 1225788005032 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1225788005033 active site 1225788005034 motif 3; other site 1225788005035 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1225788005036 anticodon binding site; other site 1225788005037 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1225788005038 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1225788005039 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1225788005040 generic binding surface II; other site 1225788005041 generic binding surface I; other site 1225788005042 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1225788005043 active site 1225788005044 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1225788005045 active site 1225788005046 catalytic site [active] 1225788005047 substrate binding site [chemical binding]; other site 1225788005048 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1225788005049 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1225788005050 Sm and related proteins; Region: Sm_like; cl00259 1225788005051 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1225788005052 putative oligomer interface [polypeptide binding]; other site 1225788005053 putative RNA binding site [nucleotide binding]; other site 1225788005054 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1225788005055 NusA N-terminal domain; Region: NusA_N; pfam08529 1225788005056 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1225788005057 RNA binding site [nucleotide binding]; other site 1225788005058 homodimer interface [polypeptide binding]; other site 1225788005059 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1225788005060 G-X-X-G motif; other site 1225788005061 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1225788005062 G-X-X-G motif; other site 1225788005063 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1225788005064 putative RNA binding cleft [nucleotide binding]; other site 1225788005065 hypothetical protein; Provisional; Region: PRK07714 1225788005066 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1225788005067 translation initiation factor IF-2; Region: IF-2; TIGR00487 1225788005068 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1225788005069 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1225788005070 G1 box; other site 1225788005071 putative GEF interaction site [polypeptide binding]; other site 1225788005072 GTP/Mg2+ binding site [chemical binding]; other site 1225788005073 Switch I region; other site 1225788005074 G2 box; other site 1225788005075 G3 box; other site 1225788005076 Switch II region; other site 1225788005077 G4 box; other site 1225788005078 G5 box; other site 1225788005079 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1225788005080 Translation-initiation factor 2; Region: IF-2; pfam11987 1225788005081 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1225788005082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1225788005083 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1225788005084 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1225788005085 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1225788005086 RNA binding site [nucleotide binding]; other site 1225788005087 active site 1225788005088 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1225788005089 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1225788005090 active site 1225788005091 Riboflavin kinase; Region: Flavokinase; smart00904 1225788005092 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1225788005093 16S/18S rRNA binding site [nucleotide binding]; other site 1225788005094 S13e-L30e interaction site [polypeptide binding]; other site 1225788005095 25S rRNA binding site [nucleotide binding]; other site 1225788005096 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1225788005097 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1225788005098 RNase E interface [polypeptide binding]; other site 1225788005099 trimer interface [polypeptide binding]; other site 1225788005100 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1225788005101 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1225788005102 RNase E interface [polypeptide binding]; other site 1225788005103 trimer interface [polypeptide binding]; other site 1225788005104 active site 1225788005105 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1225788005106 putative nucleic acid binding region [nucleotide binding]; other site 1225788005107 G-X-X-G motif; other site 1225788005108 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1225788005109 RNA binding site [nucleotide binding]; other site 1225788005110 domain interface; other site 1225788005111 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1225788005112 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1225788005113 NodB motif; other site 1225788005114 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1225788005115 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1225788005116 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1225788005117 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1225788005118 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1225788005119 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1225788005120 NAD binding site [chemical binding]; other site 1225788005121 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1225788005122 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1225788005123 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1225788005124 aspartate kinase I; Reviewed; Region: PRK08210 1225788005125 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1225788005126 putative catalytic residues [active] 1225788005127 putative nucleotide binding site [chemical binding]; other site 1225788005128 putative aspartate binding site [chemical binding]; other site 1225788005129 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1225788005130 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1225788005131 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1225788005132 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1225788005133 dimer interface [polypeptide binding]; other site 1225788005134 active site 1225788005135 catalytic residue [active] 1225788005136 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1225788005137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1225788005138 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1225788005139 Clp protease; Region: CLP_protease; pfam00574 1225788005140 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1225788005141 active site 1225788005142 YlzJ-like protein; Region: YlzJ; pfam14035 1225788005143 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1225788005144 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1225788005145 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1225788005146 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1225788005147 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1225788005148 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788005149 DNA-binding site [nucleotide binding]; DNA binding site 1225788005150 UTRA domain; Region: UTRA; pfam07702 1225788005151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788005152 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788005153 putative substrate translocation pore; other site 1225788005154 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788005155 MarR family; Region: MarR_2; pfam12802 1225788005156 MMPL family; Region: MMPL; pfam03176 1225788005157 Predicted membrane protein [Function unknown]; Region: COG1511 1225788005158 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1225788005159 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1225788005160 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1225788005161 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1225788005162 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1225788005163 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1225788005164 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1225788005165 classical (c) SDRs; Region: SDR_c; cd05233 1225788005166 NAD(P) binding site [chemical binding]; other site 1225788005167 active site 1225788005168 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1225788005169 ACT domain; Region: ACT; pfam01842 1225788005170 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1225788005171 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1225788005172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788005173 non-specific DNA binding site [nucleotide binding]; other site 1225788005174 salt bridge; other site 1225788005175 sequence-specific DNA binding site [nucleotide binding]; other site 1225788005176 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1225788005177 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1225788005178 competence damage-inducible protein A; Provisional; Region: PRK00549 1225788005179 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1225788005180 putative MPT binding site; other site 1225788005181 Competence-damaged protein; Region: CinA; pfam02464 1225788005182 recombinase A; Provisional; Region: recA; PRK09354 1225788005183 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1225788005184 hexamer interface [polypeptide binding]; other site 1225788005185 Walker A motif; other site 1225788005186 ATP binding site [chemical binding]; other site 1225788005187 Walker B motif; other site 1225788005188 Beta-lactamase; Region: Beta-lactamase; pfam00144 1225788005189 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1225788005190 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1225788005191 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1225788005192 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1225788005193 Zn2+ binding site [ion binding]; other site 1225788005194 Mg2+ binding site [ion binding]; other site 1225788005195 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1225788005196 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1225788005197 putative active site [active] 1225788005198 metal binding site [ion binding]; metal-binding site 1225788005199 homodimer binding site [polypeptide binding]; other site 1225788005200 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1225788005201 Threonine dehydrogenase; Region: TDH; cd05281 1225788005202 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1225788005203 structural Zn binding site [ion binding]; other site 1225788005204 catalytic Zn binding site [ion binding]; other site 1225788005205 tetramer interface [polypeptide binding]; other site 1225788005206 NADP binding site [chemical binding]; other site 1225788005207 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1225788005208 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1225788005209 substrate-cofactor binding pocket; other site 1225788005210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788005211 catalytic residue [active] 1225788005212 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1225788005213 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1225788005214 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1225788005215 FeS/SAM binding site; other site 1225788005216 TRAM domain; Region: TRAM; pfam01938 1225788005217 Predicted membrane protein [Function unknown]; Region: COG4550 1225788005218 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1225788005219 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1225788005220 MutS domain I; Region: MutS_I; pfam01624 1225788005221 MutS domain II; Region: MutS_II; pfam05188 1225788005222 MutS domain III; Region: MutS_III; pfam05192 1225788005223 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1225788005224 Walker A/P-loop; other site 1225788005225 ATP binding site [chemical binding]; other site 1225788005226 Q-loop/lid; other site 1225788005227 ABC transporter signature motif; other site 1225788005228 Walker B; other site 1225788005229 D-loop; other site 1225788005230 H-loop/switch region; other site 1225788005231 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1225788005232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788005233 ATP binding site [chemical binding]; other site 1225788005234 Mg2+ binding site [ion binding]; other site 1225788005235 G-X-G motif; other site 1225788005236 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1225788005237 ATP binding site [chemical binding]; other site 1225788005238 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1225788005239 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1225788005240 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1225788005241 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1225788005242 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1225788005243 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1225788005244 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1225788005245 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1225788005246 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1225788005247 FMN binding site [chemical binding]; other site 1225788005248 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1225788005249 substrate binding site [chemical binding]; other site 1225788005250 putative catalytic residue [active] 1225788005251 acyl carrier protein; Validated; Region: PRK07117 1225788005252 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1225788005253 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1225788005254 dimer interface [polypeptide binding]; other site 1225788005255 active site 1225788005256 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1225788005257 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1225788005258 substrate binding site [chemical binding]; other site 1225788005259 oxyanion hole (OAH) forming residues; other site 1225788005260 trimer interface [polypeptide binding]; other site 1225788005261 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1225788005262 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1225788005263 substrate binding site [chemical binding]; other site 1225788005264 oxyanion hole (OAH) forming residues; other site 1225788005265 trimer interface [polypeptide binding]; other site 1225788005266 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 1225788005267 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1225788005268 acyl-activating enzyme (AAE) consensus motif; other site 1225788005269 putative AMP binding site [chemical binding]; other site 1225788005270 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005271 Condensation domain; Region: Condensation; pfam00668 1225788005272 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005273 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788005274 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1225788005275 acyl-activating enzyme (AAE) consensus motif; other site 1225788005276 AMP binding site [chemical binding]; other site 1225788005277 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005278 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1225788005279 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788005280 active site 1225788005281 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788005282 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788005283 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788005284 putative NADP binding site [chemical binding]; other site 1225788005285 active site 1225788005286 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005287 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788005288 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788005289 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1225788005290 active site 1225788005291 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788005292 putative NADP binding site [chemical binding]; other site 1225788005293 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788005294 active site 1225788005295 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005296 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788005297 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788005298 active site 1225788005299 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788005300 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1225788005301 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788005302 active site 1225788005303 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788005304 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788005305 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788005306 putative NADP binding site [chemical binding]; other site 1225788005307 active site 1225788005308 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788005309 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788005310 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788005311 active site 1225788005312 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788005313 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788005314 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788005315 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788005316 active site 1225788005317 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788005318 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788005319 putative NADP binding site [chemical binding]; other site 1225788005320 active site 1225788005321 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005322 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788005323 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788005324 active site 1225788005325 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788005326 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005327 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788005328 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1225788005329 active site 1225788005330 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788005331 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788005332 putative NADP binding site [chemical binding]; other site 1225788005333 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788005334 active site 1225788005335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788005336 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005337 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788005338 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788005339 active site 1225788005340 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788005341 putative NADP binding site [chemical binding]; other site 1225788005342 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788005343 active site 1225788005344 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005345 Condensation domain; Region: Condensation; pfam00668 1225788005346 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005347 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788005348 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005349 acyl-activating enzyme (AAE) consensus motif; other site 1225788005350 AMP binding site [chemical binding]; other site 1225788005351 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005352 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1225788005353 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788005354 active site 1225788005355 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788005356 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788005357 putative NADP binding site [chemical binding]; other site 1225788005358 KR domain; Region: KR; pfam08659 1225788005359 active site 1225788005360 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788005361 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1225788005362 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788005363 active site 1225788005364 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788005365 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788005366 putative NADP binding site [chemical binding]; other site 1225788005367 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788005368 active site 1225788005369 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788005370 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1225788005371 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788005372 active site 1225788005373 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788005374 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788005375 putative NADP binding site [chemical binding]; other site 1225788005376 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788005377 active site 1225788005378 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1225788005379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788005380 S-adenosylmethionine binding site [chemical binding]; other site 1225788005381 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788005382 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788005383 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788005384 active site 1225788005385 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788005386 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1225788005387 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788005388 active site 1225788005389 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005390 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1225788005391 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1225788005392 Cytochrome P450; Region: p450; cl12078 1225788005393 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1225788005394 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1225788005395 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1225788005396 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1225788005397 active site 1225788005398 catalytic triad [active] 1225788005399 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1225788005400 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1225788005401 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1225788005402 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1225788005403 YmaF family; Region: YmaF; pfam12788 1225788005404 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1225788005405 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1225788005406 bacterial Hfq-like; Region: Hfq; cd01716 1225788005407 hexamer interface [polypeptide binding]; other site 1225788005408 Sm1 motif; other site 1225788005409 RNA binding site [nucleotide binding]; other site 1225788005410 Sm2 motif; other site 1225788005411 YmzC-like protein; Region: YmzC; pfam14157 1225788005412 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1225788005413 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1225788005414 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1225788005415 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1225788005416 active site 1225788005417 dimer interface [polypeptide binding]; other site 1225788005418 catalytic residues [active] 1225788005419 effector binding site; other site 1225788005420 R2 peptide binding site; other site 1225788005421 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1225788005422 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1225788005423 dimer interface [polypeptide binding]; other site 1225788005424 putative radical transfer pathway; other site 1225788005425 diiron center [ion binding]; other site 1225788005426 tyrosyl radical; other site 1225788005427 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1225788005428 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1225788005429 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1225788005430 active site 1225788005431 metal binding site [ion binding]; metal-binding site 1225788005432 Sporulation related domain; Region: SPOR; pfam05036 1225788005433 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1225788005434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788005435 Walker A motif; other site 1225788005436 ATP binding site [chemical binding]; other site 1225788005437 Walker B motif; other site 1225788005438 arginine finger; other site 1225788005439 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1225788005440 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1225788005441 HflX GTPase family; Region: HflX; cd01878 1225788005442 G1 box; other site 1225788005443 GTP/Mg2+ binding site [chemical binding]; other site 1225788005444 Switch I region; other site 1225788005445 G2 box; other site 1225788005446 G3 box; other site 1225788005447 Switch II region; other site 1225788005448 G4 box; other site 1225788005449 G5 box; other site 1225788005450 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1225788005451 Aluminium resistance protein; Region: Alum_res; pfam06838 1225788005452 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1225788005453 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1225788005454 DNA binding residues [nucleotide binding] 1225788005455 glutamine synthetase, type I; Region: GlnA; TIGR00653 1225788005456 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1225788005457 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1225788005458 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1225788005459 Major royal jelly protein; Region: MRJP; pfam03022 1225788005460 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1225788005461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788005462 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1225788005463 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1225788005464 inhibitor binding site; inhibition site 1225788005465 active site 1225788005466 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1225788005467 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1225788005468 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1225788005469 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1225788005470 nucleotide binding site [chemical binding]; other site 1225788005471 xylose isomerase; Provisional; Region: PRK05474 1225788005472 xylose isomerase; Region: xylose_isom_A; TIGR02630 1225788005473 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1225788005474 N- and C-terminal domain interface [polypeptide binding]; other site 1225788005475 D-xylulose kinase; Region: XylB; TIGR01312 1225788005476 active site 1225788005477 MgATP binding site [chemical binding]; other site 1225788005478 catalytic site [active] 1225788005479 metal binding site [ion binding]; metal-binding site 1225788005480 xylulose binding site [chemical binding]; other site 1225788005481 homodimer interface [polypeptide binding]; other site 1225788005482 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1225788005483 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1225788005484 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1225788005485 DinB family; Region: DinB; cl17821 1225788005486 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1225788005487 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1225788005488 NAD binding site [chemical binding]; other site 1225788005489 substrate binding site [chemical binding]; other site 1225788005490 catalytic Zn binding site [ion binding]; other site 1225788005491 tetramer interface [polypeptide binding]; other site 1225788005492 structural Zn binding site [ion binding]; other site 1225788005493 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1225788005494 putative CoA binding site [chemical binding]; other site 1225788005495 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 1225788005496 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1225788005497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788005498 Coenzyme A binding pocket [chemical binding]; other site 1225788005499 YoaP-like; Region: YoaP; pfam14268 1225788005500 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1225788005501 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1225788005502 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 1225788005503 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1225788005504 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1225788005505 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1225788005506 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1225788005507 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1225788005508 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1225788005509 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1225788005510 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1225788005511 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1225788005512 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1225788005513 trimer interface [polypeptide binding]; other site 1225788005514 active site 1225788005515 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1225788005516 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 1225788005517 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1225788005518 LexA repressor; Validated; Region: PRK00215 1225788005519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1225788005520 putative DNA binding site [nucleotide binding]; other site 1225788005521 putative Zn2+ binding site [ion binding]; other site 1225788005522 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1225788005523 Catalytic site [active] 1225788005524 cell division suppressor protein YneA; Provisional; Region: PRK14125 1225788005525 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788005526 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1225788005527 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1225788005528 catalytic residues [active] 1225788005529 catalytic nucleophile [active] 1225788005530 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1225788005531 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1225788005532 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1225788005533 TPP-binding site [chemical binding]; other site 1225788005534 dimer interface [polypeptide binding]; other site 1225788005535 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1225788005536 PYR/PP interface [polypeptide binding]; other site 1225788005537 dimer interface [polypeptide binding]; other site 1225788005538 TPP binding site [chemical binding]; other site 1225788005539 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1225788005540 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1225788005541 hypothetical protein; Provisional; Region: PRK01844 1225788005542 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1225788005543 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1225788005544 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1225788005545 Response regulator receiver domain; Region: Response_reg; pfam00072 1225788005546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788005547 active site 1225788005548 phosphorylation site [posttranslational modification] 1225788005549 intermolecular recognition site; other site 1225788005550 dimerization interface [polypeptide binding]; other site 1225788005551 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1225788005552 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1225788005553 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1225788005554 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1225788005555 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 1225788005556 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1225788005557 aconitate hydratase; Validated; Region: PRK09277 1225788005558 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1225788005559 substrate binding site [chemical binding]; other site 1225788005560 ligand binding site [chemical binding]; other site 1225788005561 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1225788005562 substrate binding site [chemical binding]; other site 1225788005563 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1225788005564 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1225788005565 catalytic residues [active] 1225788005566 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1225788005567 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1225788005568 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1225788005569 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1225788005570 active site 1225788005571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1225788005572 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1225788005573 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1225788005574 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1225788005575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788005576 ATP binding site [chemical binding]; other site 1225788005577 Mg2+ binding site [ion binding]; other site 1225788005578 G-X-G motif; other site 1225788005579 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1225788005580 anchoring element; other site 1225788005581 dimer interface [polypeptide binding]; other site 1225788005582 ATP binding site [chemical binding]; other site 1225788005583 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1225788005584 active site 1225788005585 putative metal-binding site [ion binding]; other site 1225788005586 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1225788005587 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1225788005588 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1225788005589 CAP-like domain; other site 1225788005590 active site 1225788005591 primary dimer interface [polypeptide binding]; other site 1225788005592 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1225788005593 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1225788005594 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1225788005595 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1225788005596 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1225788005597 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1225788005598 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1225788005599 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1225788005600 substrate binding site [chemical binding]; other site 1225788005601 ATP binding site [chemical binding]; other site 1225788005602 putative oxidoreductase; Provisional; Region: PRK10083 1225788005603 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1225788005604 putative NAD(P) binding site [chemical binding]; other site 1225788005605 catalytic Zn binding site [ion binding]; other site 1225788005606 structural Zn binding site [ion binding]; other site 1225788005607 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1225788005608 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1225788005609 active site 1225788005610 intersubunit interface [polypeptide binding]; other site 1225788005611 catalytic residue [active] 1225788005612 mannonate dehydratase; Provisional; Region: PRK03906 1225788005613 mannonate dehydratase; Region: uxuA; TIGR00695 1225788005614 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1225788005615 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1225788005616 putative NAD(P) binding site [chemical binding]; other site 1225788005617 active site 1225788005618 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1225788005619 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1225788005620 DNA binding site [nucleotide binding] 1225788005621 domain linker motif; other site 1225788005622 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1225788005623 putative dimerization interface [polypeptide binding]; other site 1225788005624 putative ligand binding site [chemical binding]; other site 1225788005625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788005626 D-galactonate transporter; Region: 2A0114; TIGR00893 1225788005627 putative substrate translocation pore; other site 1225788005628 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1225788005629 YndJ-like protein; Region: YndJ; pfam14158 1225788005630 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1225788005631 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1225788005632 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1225788005633 Cellulose binding domain; Region: CBM_3; pfam00942 1225788005634 Tic20-like protein; Region: Tic20; pfam09685 1225788005635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1225788005636 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1225788005637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788005638 dimer interface [polypeptide binding]; other site 1225788005639 phosphorylation site [posttranslational modification] 1225788005640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788005641 ATP binding site [chemical binding]; other site 1225788005642 Mg2+ binding site [ion binding]; other site 1225788005643 G-X-G motif; other site 1225788005644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788005645 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1225788005646 active site 1225788005647 phosphorylation site [posttranslational modification] 1225788005648 intermolecular recognition site; other site 1225788005649 dimerization interface [polypeptide binding]; other site 1225788005650 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1225788005651 DNA binding site [nucleotide binding] 1225788005652 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1225788005653 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1225788005654 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1225788005655 substrate binding site [chemical binding]; other site 1225788005656 active site 1225788005657 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1225788005658 metal binding site [ion binding]; metal-binding site 1225788005659 ligand binding site [chemical binding]; other site 1225788005660 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005661 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1225788005662 acyl-activating enzyme (AAE) consensus motif; other site 1225788005663 AMP binding site [chemical binding]; other site 1225788005664 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005665 Condensation domain; Region: Condensation; pfam00668 1225788005666 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005667 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1225788005668 Condensation domain; Region: Condensation; pfam00668 1225788005669 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005670 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005671 acyl-activating enzyme (AAE) consensus motif; other site 1225788005672 AMP binding site [chemical binding]; other site 1225788005673 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005674 Thioesterase domain; Region: Thioesterase; pfam00975 1225788005675 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005676 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788005677 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005678 acyl-activating enzyme (AAE) consensus motif; other site 1225788005679 AMP binding site [chemical binding]; other site 1225788005680 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005681 Condensation domain; Region: Condensation; pfam00668 1225788005682 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005683 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1225788005684 Condensation domain; Region: Condensation; pfam00668 1225788005685 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005686 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005687 acyl-activating enzyme (AAE) consensus motif; other site 1225788005688 AMP binding site [chemical binding]; other site 1225788005689 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005690 Condensation domain; Region: Condensation; pfam00668 1225788005691 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005692 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1225788005693 Condensation domain; Region: Condensation; pfam00668 1225788005694 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005695 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005696 acyl-activating enzyme (AAE) consensus motif; other site 1225788005697 AMP binding site [chemical binding]; other site 1225788005698 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005699 Condensation domain; Region: Condensation; pfam00668 1225788005700 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005701 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788005702 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005703 acyl-activating enzyme (AAE) consensus motif; other site 1225788005704 AMP binding site [chemical binding]; other site 1225788005705 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005706 Condensation domain; Region: Condensation; pfam00668 1225788005707 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005708 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788005709 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1225788005710 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 1225788005711 acyl-activating enzyme (AAE) consensus motif; other site 1225788005712 putative AMP binding site [chemical binding]; other site 1225788005713 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005714 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788005715 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788005716 active site 1225788005717 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005718 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1225788005719 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1225788005720 inhibitor-cofactor binding pocket; inhibition site 1225788005721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788005722 catalytic residue [active] 1225788005723 Condensation domain; Region: Condensation; pfam00668 1225788005724 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005725 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005726 Condensation domain; Region: Condensation; pfam00668 1225788005727 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005728 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788005729 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005730 acyl-activating enzyme (AAE) consensus motif; other site 1225788005731 AMP binding site [chemical binding]; other site 1225788005732 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005733 Condensation domain; Region: Condensation; pfam00668 1225788005734 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005735 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788005736 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1225788005737 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1225788005738 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1225788005739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1225788005740 NAD(P) binding site [chemical binding]; other site 1225788005741 active site 1225788005742 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1225788005743 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1225788005744 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1225788005745 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1225788005746 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1225788005747 Cytochrome P450; Region: p450; cl12078 1225788005748 biotin synthase; Validated; Region: PRK06256 1225788005749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1225788005750 FeS/SAM binding site; other site 1225788005751 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1225788005752 AAA domain; Region: AAA_26; pfam13500 1225788005753 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1225788005754 active site 1225788005755 ADP binding site [chemical binding]; other site 1225788005756 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1225788005757 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1225788005758 substrate-cofactor binding pocket; other site 1225788005759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788005760 catalytic residue [active] 1225788005761 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1225788005762 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1225788005763 inhibitor-cofactor binding pocket; inhibition site 1225788005764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788005765 catalytic residue [active] 1225788005766 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 1225788005767 Predicted membrane protein [Function unknown]; Region: COG2246 1225788005768 GtrA-like protein; Region: GtrA; pfam04138 1225788005769 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1225788005770 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1225788005771 active site 1225788005772 tetramer interface; other site 1225788005773 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1225788005774 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1225788005775 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1225788005776 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1225788005777 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1225788005778 enoyl-CoA hydratase; Provisional; Region: PRK07657 1225788005779 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1225788005780 substrate binding site [chemical binding]; other site 1225788005781 oxyanion hole (OAH) forming residues; other site 1225788005782 trimer interface [polypeptide binding]; other site 1225788005783 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1225788005784 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1225788005785 active site 1225788005786 catalytic residues [active] 1225788005787 metal binding site [ion binding]; metal-binding site 1225788005788 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1225788005789 carboxyltransferase (CT) interaction site; other site 1225788005790 biotinylation site [posttranslational modification]; other site 1225788005791 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1225788005792 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1225788005793 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1225788005794 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1225788005795 AMP-binding domain protein; Validated; Region: PRK08315 1225788005796 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1225788005797 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1225788005798 acyl-activating enzyme (AAE) consensus motif; other site 1225788005799 putative AMP binding site [chemical binding]; other site 1225788005800 putative active site [active] 1225788005801 putative CoA binding site [chemical binding]; other site 1225788005802 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1225788005803 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1225788005804 FAD binding site [chemical binding]; other site 1225788005805 homotetramer interface [polypeptide binding]; other site 1225788005806 substrate binding pocket [chemical binding]; other site 1225788005807 catalytic base [active] 1225788005808 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1225788005809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1225788005810 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1225788005811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1225788005812 HTH-like domain; Region: HTH_21; pfam13276 1225788005813 Integrase core domain; Region: rve; pfam00665 1225788005814 Integrase core domain; Region: rve_3; pfam13683 1225788005815 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1225788005816 Condensation domain; Region: Condensation; pfam00668 1225788005817 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005818 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1225788005819 acyl-activating enzyme (AAE) consensus motif; other site 1225788005820 AMP binding site [chemical binding]; other site 1225788005821 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005822 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1225788005823 Condensation domain; Region: Condensation; pfam00668 1225788005824 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005825 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005826 acyl-activating enzyme (AAE) consensus motif; other site 1225788005827 AMP binding site [chemical binding]; other site 1225788005828 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005829 Condensation domain; Region: Condensation; pfam00668 1225788005830 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005831 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788005832 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005833 acyl-activating enzyme (AAE) consensus motif; other site 1225788005834 AMP binding site [chemical binding]; other site 1225788005835 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005836 Condensation domain; Region: Condensation; pfam00668 1225788005837 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005838 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788005839 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005840 acyl-activating enzyme (AAE) consensus motif; other site 1225788005841 AMP binding site [chemical binding]; other site 1225788005842 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005843 Condensation domain; Region: Condensation; pfam00668 1225788005844 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1225788005845 Condensation domain; Region: Condensation; pfam00668 1225788005846 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005847 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005848 acyl-activating enzyme (AAE) consensus motif; other site 1225788005849 AMP binding site [chemical binding]; other site 1225788005850 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005851 Condensation domain; Region: Condensation; pfam00668 1225788005852 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005853 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788005854 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1225788005855 acyl-activating enzyme (AAE) consensus motif; other site 1225788005856 AMP binding site [chemical binding]; other site 1225788005857 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005858 Condensation domain; Region: Condensation; pfam00668 1225788005859 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1225788005860 Condensation domain; Region: Condensation; pfam00668 1225788005861 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005862 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005863 acyl-activating enzyme (AAE) consensus motif; other site 1225788005864 AMP binding site [chemical binding]; other site 1225788005865 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005866 Condensation domain; Region: Condensation; pfam00668 1225788005867 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005868 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788005869 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1225788005870 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005871 acyl-activating enzyme (AAE) consensus motif; other site 1225788005872 AMP binding site [chemical binding]; other site 1225788005873 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005874 Condensation domain; Region: Condensation; pfam00668 1225788005875 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1225788005876 Condensation domain; Region: Condensation; pfam00668 1225788005877 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005878 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788005879 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005880 acyl-activating enzyme (AAE) consensus motif; other site 1225788005881 AMP binding site [chemical binding]; other site 1225788005882 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005883 Condensation domain; Region: Condensation; pfam00668 1225788005884 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005885 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788005886 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788005887 acyl-activating enzyme (AAE) consensus motif; other site 1225788005888 AMP binding site [chemical binding]; other site 1225788005889 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788005890 Condensation domain; Region: Condensation; pfam00668 1225788005891 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1225788005892 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1225788005893 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1225788005894 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1225788005895 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1225788005896 active site 1225788005897 catalytic residues [active] 1225788005898 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1225788005899 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1225788005900 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1225788005901 Int/Topo IB signature motif; other site 1225788005902 Helix-turn-helix domain; Region: HTH_17; cl17695 1225788005903 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1225788005904 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1225788005905 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1225788005906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788005907 putative substrate translocation pore; other site 1225788005908 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1225788005909 dimerization interface [polypeptide binding]; other site 1225788005910 putative DNA binding site [nucleotide binding]; other site 1225788005911 putative Zn2+ binding site [ion binding]; other site 1225788005912 potential frameshift: common BLAST hit: gi|384265612|ref|YP_005421319.1| threonyl-tRNA synthetase 1225788005913 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788005914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788005915 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1225788005916 putative dimerization interface [polypeptide binding]; other site 1225788005917 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1225788005918 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1225788005919 NAD(P) binding site [chemical binding]; other site 1225788005920 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1225788005921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1225788005922 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1225788005923 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1225788005924 active site 1225788005925 dimer interface [polypeptide binding]; other site 1225788005926 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1225788005927 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1225788005928 active site 1225788005929 FMN binding site [chemical binding]; other site 1225788005930 substrate binding site [chemical binding]; other site 1225788005931 3Fe-4S cluster binding site [ion binding]; other site 1225788005932 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1225788005933 domain interface; other site 1225788005934 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788005935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788005936 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1225788005937 putative dimerization interface [polypeptide binding]; other site 1225788005938 gamma-glutamyl kinase; Provisional; Region: PRK13402 1225788005939 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1225788005940 nucleotide binding site [chemical binding]; other site 1225788005941 homotetrameric interface [polypeptide binding]; other site 1225788005942 putative phosphate binding site [ion binding]; other site 1225788005943 putative allosteric binding site; other site 1225788005944 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1225788005945 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1225788005946 Replication terminator protein; Region: RTP; pfam02334 1225788005947 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1225788005948 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1225788005949 Coenzyme A binding pocket [chemical binding]; other site 1225788005950 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1225788005951 classical (c) SDRs; Region: SDR_c; cd05233 1225788005952 NAD(P) binding site [chemical binding]; other site 1225788005953 active site 1225788005954 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1225788005955 polyol permease family; Region: 2A0118; TIGR00897 1225788005956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788005957 putative substrate translocation pore; other site 1225788005958 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1225788005959 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1225788005960 nucleotide binding site [chemical binding]; other site 1225788005961 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1225788005962 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1225788005963 putative ligand binding site [chemical binding]; other site 1225788005964 putative NAD binding site [chemical binding]; other site 1225788005965 catalytic site [active] 1225788005966 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1225788005967 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1225788005968 putative [4Fe-4S] binding site [ion binding]; other site 1225788005969 putative molybdopterin cofactor binding site [chemical binding]; other site 1225788005970 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1225788005971 putative molybdopterin cofactor binding site; other site 1225788005972 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788005973 MarR family; Region: MarR_2; pfam12802 1225788005974 MarR family; Region: MarR_2; cl17246 1225788005975 Predicted transcriptional regulators [Transcription]; Region: COG1733 1225788005976 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1225788005977 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1225788005978 dimer interface [polypeptide binding]; other site 1225788005979 putative tRNA-binding site [nucleotide binding]; other site 1225788005980 Cupin domain; Region: Cupin_2; pfam07883 1225788005981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1225788005982 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1225788005983 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1225788005984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788005985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788005986 WHG domain; Region: WHG; pfam13305 1225788005987 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1225788005988 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1225788005989 dimerization interface [polypeptide binding]; other site 1225788005990 putative DNA binding site [nucleotide binding]; other site 1225788005991 putative Zn2+ binding site [ion binding]; other site 1225788005992 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1225788005993 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1225788005994 catalytic residue [active] 1225788005995 Predicted membrane protein [Function unknown]; Region: COG2322 1225788005996 Protein required for attachment to host cells; Region: Host_attach; cl02398 1225788005997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1225788005998 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1225788005999 putative dimer interface [polypeptide binding]; other site 1225788006000 catalytic triad [active] 1225788006001 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788006002 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788006003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1225788006004 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1225788006005 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1225788006006 ATP binding site [chemical binding]; other site 1225788006007 putative Mg++ binding site [ion binding]; other site 1225788006008 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1225788006009 nucleotide binding region [chemical binding]; other site 1225788006010 ATP-binding site [chemical binding]; other site 1225788006011 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1225788006012 HRDC domain; Region: HRDC; pfam00570 1225788006013 azoreductase; Provisional; Region: PRK13556 1225788006014 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1225788006015 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1225788006016 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1225788006017 putative dimer interface [polypeptide binding]; other site 1225788006018 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1225788006019 pentamer interface [polypeptide binding]; other site 1225788006020 dodecaamer interface [polypeptide binding]; other site 1225788006021 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1225788006022 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1225788006023 NAD(P) binding site [chemical binding]; other site 1225788006024 catalytic residues [active] 1225788006025 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1225788006026 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1225788006027 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1225788006028 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1225788006029 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1225788006030 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1225788006031 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1225788006032 Na2 binding site [ion binding]; other site 1225788006033 putative substrate binding site 1 [chemical binding]; other site 1225788006034 Na binding site 1 [ion binding]; other site 1225788006035 putative substrate binding site 2 [chemical binding]; other site 1225788006036 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1225788006037 Sodium Bile acid symporter family; Region: SBF; pfam01758 1225788006038 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1225788006039 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1225788006040 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1225788006041 E3 interaction surface; other site 1225788006042 lipoyl attachment site [posttranslational modification]; other site 1225788006043 e3 binding domain; Region: E3_binding; pfam02817 1225788006044 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1225788006045 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1225788006046 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1225788006047 TPP-binding site [chemical binding]; other site 1225788006048 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1225788006049 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1225788006050 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1225788006051 metal ion-dependent adhesion site (MIDAS); other site 1225788006052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788006053 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1225788006054 Walker A motif; other site 1225788006055 ATP binding site [chemical binding]; other site 1225788006056 Walker B motif; other site 1225788006057 arginine finger; other site 1225788006058 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1225788006059 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1225788006060 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1225788006061 E-class dimer interface [polypeptide binding]; other site 1225788006062 P-class dimer interface [polypeptide binding]; other site 1225788006063 active site 1225788006064 Cu2+ binding site [ion binding]; other site 1225788006065 Zn2+ binding site [ion binding]; other site 1225788006066 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788006067 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1225788006068 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788006069 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1225788006070 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788006071 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1225788006072 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788006073 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1225788006074 NlpC/P60 family; Region: NLPC_P60; pfam00877 1225788006075 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1225788006076 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1225788006077 active site 1225788006078 TDP-binding site; other site 1225788006079 acceptor substrate-binding pocket; other site 1225788006080 homodimer interface [polypeptide binding]; other site 1225788006081 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1225788006082 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1225788006083 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1225788006084 multidrug efflux protein; Reviewed; Region: PRK01766 1225788006085 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1225788006086 cation binding site [ion binding]; other site 1225788006087 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1225788006088 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1225788006089 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1225788006090 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1225788006091 EamA-like transporter family; Region: EamA; pfam00892 1225788006092 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1225788006093 Predicted transcriptional regulators [Transcription]; Region: COG1733 1225788006094 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1225788006095 dimerization interface [polypeptide binding]; other site 1225788006096 putative DNA binding site [nucleotide binding]; other site 1225788006097 putative Zn2+ binding site [ion binding]; other site 1225788006098 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1225788006099 dimer interface [polypeptide binding]; other site 1225788006100 FMN binding site [chemical binding]; other site 1225788006101 Predicted esterase [General function prediction only]; Region: COG0400 1225788006102 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1225788006103 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1225788006104 Zn binding site [ion binding]; other site 1225788006105 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1225788006106 Zn binding site [ion binding]; other site 1225788006107 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1225788006108 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1225788006109 Na binding site [ion binding]; other site 1225788006110 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1225788006111 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1225788006112 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1225788006113 beta-galactosidase; Region: BGL; TIGR03356 1225788006114 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1225788006115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788006116 DNA-binding site [nucleotide binding]; DNA binding site 1225788006117 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1225788006118 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1225788006119 C-terminal peptidase (prc); Region: prc; TIGR00225 1225788006120 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1225788006121 protein binding site [polypeptide binding]; other site 1225788006122 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1225788006123 Catalytic dyad [active] 1225788006124 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1225788006125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788006126 S-adenosylmethionine binding site [chemical binding]; other site 1225788006127 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1225788006128 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1225788006129 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1225788006130 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1225788006131 YodL-like; Region: YodL; pfam14191 1225788006132 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1225788006133 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1225788006134 active site 1225788006135 YozD-like protein; Region: YozD; pfam14162 1225788006136 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1225788006137 hypothetical protein; Provisional; Region: PRK13672 1225788006138 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1225788006139 Zn binding site [ion binding]; other site 1225788006140 toxin interface [polypeptide binding]; other site 1225788006141 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1225788006142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1225788006143 FeS/SAM binding site; other site 1225788006144 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1225788006145 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1225788006146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788006147 Coenzyme A binding pocket [chemical binding]; other site 1225788006148 acetylornithine deacetylase; Validated; Region: PRK06915 1225788006149 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1225788006150 metal binding site [ion binding]; metal-binding site 1225788006151 dimer interface [polypeptide binding]; other site 1225788006152 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1225788006153 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1225788006154 hypothetical protein; Provisional; Region: PRK06917 1225788006155 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1225788006156 inhibitor-cofactor binding pocket; inhibition site 1225788006157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788006158 catalytic residue [active] 1225788006159 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1225788006160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788006161 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1225788006162 Coenzyme A binding pocket [chemical binding]; other site 1225788006163 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1225788006164 active site 1225788006165 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1225788006166 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1225788006167 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1225788006168 Phytase; Region: Phytase; cl17685 1225788006169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1225788006170 NAD(P) binding site [chemical binding]; other site 1225788006171 active site 1225788006172 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 1225788006173 YoqO-like protein; Region: YoqO; pfam14037 1225788006174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788006175 TPR motif; other site 1225788006176 binding surface 1225788006177 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788006178 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788006179 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1225788006180 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1225788006181 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1225788006182 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1225788006183 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1225788006184 Staphylococcal nuclease homologues; Region: SNc; smart00318 1225788006185 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1225788006186 Catalytic site; other site 1225788006187 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1225788006188 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1225788006189 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1225788006190 catalytic residues [active] 1225788006191 catalytic nucleophile [active] 1225788006192 Recombinase; Region: Recombinase; pfam07508 1225788006193 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1225788006194 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1225788006195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1225788006196 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1225788006197 SelR domain; Region: SelR; pfam01641 1225788006198 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1225788006199 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788006200 MarR family; Region: MarR; pfam01047 1225788006201 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1225788006202 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1225788006203 active site 1225788006204 catalytic triad [active] 1225788006205 oxyanion hole [active] 1225788006206 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1225788006207 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1225788006208 Cu(I) binding site [ion binding]; other site 1225788006209 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1225788006210 threonine dehydratase; Validated; Region: PRK08639 1225788006211 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1225788006212 tetramer interface [polypeptide binding]; other site 1225788006213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788006214 catalytic residue [active] 1225788006215 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1225788006216 putative Ile/Val binding site [chemical binding]; other site 1225788006217 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788006218 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1225788006219 Walker A motif; other site 1225788006220 ATP binding site [chemical binding]; other site 1225788006221 Walker B motif; other site 1225788006222 arginine finger; other site 1225788006223 Haemolysin-III related; Region: HlyIII; cl03831 1225788006224 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1225788006225 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1225788006226 putative acyl-acceptor binding pocket; other site 1225788006227 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1225788006228 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1225788006229 folate binding site [chemical binding]; other site 1225788006230 NADP+ binding site [chemical binding]; other site 1225788006231 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1225788006232 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1225788006233 dimerization interface [polypeptide binding]; other site 1225788006234 active site 1225788006235 YpjP-like protein; Region: YpjP; pfam14005 1225788006236 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1225788006237 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1225788006238 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1225788006239 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1225788006240 Virulence factor; Region: Virulence_fact; pfam13769 1225788006241 HEAT repeats; Region: HEAT_2; pfam13646 1225788006242 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1225788006243 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1225788006244 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1225788006245 Zn2+ binding site [ion binding]; other site 1225788006246 Mg2+ binding site [ion binding]; other site 1225788006247 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1225788006248 catalytic residues [active] 1225788006249 dimer interface [polypeptide binding]; other site 1225788006250 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1225788006251 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1225788006252 proposed active site lysine [active] 1225788006253 conserved cys residue [active] 1225788006254 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1225788006255 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1225788006256 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1225788006257 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1225788006258 DNA-binding site [nucleotide binding]; DNA binding site 1225788006259 RNA-binding motif; other site 1225788006260 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1225788006261 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1225788006262 hypothetical protein; Validated; Region: PRK07708 1225788006263 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1225788006264 RNA/DNA hybrid binding site [nucleotide binding]; other site 1225788006265 active site 1225788006266 conserved hypothetical integral membrane protein; Region: TIGR00697 1225788006267 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1225788006268 RNA/DNA hybrid binding site [nucleotide binding]; other site 1225788006269 active site 1225788006270 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1225788006271 5'-3' exonuclease; Region: 53EXOc; smart00475 1225788006272 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1225788006273 active site 1225788006274 metal binding site 1 [ion binding]; metal-binding site 1225788006275 putative 5' ssDNA interaction site; other site 1225788006276 metal binding site 3; metal-binding site 1225788006277 metal binding site 2 [ion binding]; metal-binding site 1225788006278 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1225788006279 putative DNA binding site [nucleotide binding]; other site 1225788006280 putative metal binding site [ion binding]; other site 1225788006281 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1225788006282 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1225788006283 Dynamin family; Region: Dynamin_N; pfam00350 1225788006284 G1 box; other site 1225788006285 GTP/Mg2+ binding site [chemical binding]; other site 1225788006286 G2 box; other site 1225788006287 Switch I region; other site 1225788006288 G3 box; other site 1225788006289 Switch II region; other site 1225788006290 G4 box; other site 1225788006291 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1225788006292 G1 box; other site 1225788006293 GTP/Mg2+ binding site [chemical binding]; other site 1225788006294 Dynamin family; Region: Dynamin_N; pfam00350 1225788006295 G2 box; other site 1225788006296 Switch I region; other site 1225788006297 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1225788006298 G3 box; other site 1225788006299 Switch II region; other site 1225788006300 GTP/Mg2+ binding site [chemical binding]; other site 1225788006301 G4 box; other site 1225788006302 G5 box; other site 1225788006303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1225788006304 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1225788006305 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1225788006306 malonyl-CoA binding site [chemical binding]; other site 1225788006307 dimer interface [polypeptide binding]; other site 1225788006308 active site 1225788006309 product binding site; other site 1225788006310 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1225788006311 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1225788006312 DNA binding site [nucleotide binding] 1225788006313 active site 1225788006314 Predicted membrane protein [Function unknown]; Region: COG2323 1225788006315 Isochorismatase family; Region: Isochorismatase; pfam00857 1225788006316 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1225788006317 catalytic triad [active] 1225788006318 conserved cis-peptide bond; other site 1225788006319 xanthine permease; Region: pbuX; TIGR03173 1225788006320 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1225788006321 active site 1225788006322 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1225788006323 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1225788006324 active site 1225788006325 Zn binding site [ion binding]; other site 1225788006326 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1225788006327 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1225788006328 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1225788006329 YpzG-like protein; Region: YpzG; pfam14139 1225788006330 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1225788006331 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1225788006332 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1225788006333 cell division protein GpsB; Provisional; Region: PRK14127 1225788006334 DivIVA domain; Region: DivI1A_domain; TIGR03544 1225788006335 hypothetical protein; Provisional; Region: PRK13660 1225788006336 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 1225788006337 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1225788006338 RNase_H superfamily; Region: RNase_H_2; pfam13482 1225788006339 active site 1225788006340 substrate binding site [chemical binding]; other site 1225788006341 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1225788006342 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1225788006343 ATP binding site [chemical binding]; other site 1225788006344 putative Mg++ binding site [ion binding]; other site 1225788006345 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1225788006346 nucleotide binding region [chemical binding]; other site 1225788006347 ATP-binding site [chemical binding]; other site 1225788006348 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1225788006349 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1225788006350 HPr interaction site; other site 1225788006351 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1225788006352 active site 1225788006353 phosphorylation site [posttranslational modification] 1225788006354 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1225788006355 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1225788006356 putative dimer interface [polypeptide binding]; other site 1225788006357 YppG-like protein; Region: YppG; pfam14179 1225788006358 YppF-like protein; Region: YppF; pfam14178 1225788006359 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1225788006360 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1225788006361 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1225788006362 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1225788006363 Transglycosylase; Region: Transgly; pfam00912 1225788006364 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1225788006365 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1225788006366 Interdomain contacts; other site 1225788006367 Cytokine receptor motif; other site 1225788006368 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1225788006369 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1225788006370 minor groove reading motif; other site 1225788006371 helix-hairpin-helix signature motif; other site 1225788006372 substrate binding pocket [chemical binding]; other site 1225788006373 active site 1225788006374 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1225788006375 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1225788006376 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1225788006377 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1225788006378 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1225788006379 putative dimer interface [polypeptide binding]; other site 1225788006380 putative anticodon binding site; other site 1225788006381 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1225788006382 homodimer interface [polypeptide binding]; other site 1225788006383 motif 1; other site 1225788006384 motif 2; other site 1225788006385 active site 1225788006386 motif 3; other site 1225788006387 aspartate aminotransferase; Provisional; Region: PRK05764 1225788006388 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1225788006389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788006390 homodimer interface [polypeptide binding]; other site 1225788006391 catalytic residue [active] 1225788006392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1225788006393 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1225788006394 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1225788006395 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1225788006396 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1225788006397 active site 1225788006398 catalytic site [active] 1225788006399 substrate binding site [chemical binding]; other site 1225788006400 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1225788006401 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1225788006402 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1225788006403 tetramerization interface [polypeptide binding]; other site 1225788006404 active site 1225788006405 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1225788006406 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1225788006407 active site 1225788006408 ATP-binding site [chemical binding]; other site 1225788006409 pantoate-binding site; other site 1225788006410 HXXH motif; other site 1225788006411 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1225788006412 oligomerization interface [polypeptide binding]; other site 1225788006413 active site 1225788006414 metal binding site [ion binding]; metal-binding site 1225788006415 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1225788006416 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1225788006417 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1225788006418 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1225788006419 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1225788006420 active site 1225788006421 NTP binding site [chemical binding]; other site 1225788006422 metal binding triad [ion binding]; metal-binding site 1225788006423 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1225788006424 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1225788006425 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1225788006426 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1225788006427 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1225788006428 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1225788006429 active site 1225788006430 dimer interfaces [polypeptide binding]; other site 1225788006431 catalytic residues [active] 1225788006432 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1225788006433 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1225788006434 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1225788006435 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1225788006436 homodimer interface [polypeptide binding]; other site 1225788006437 metal binding site [ion binding]; metal-binding site 1225788006438 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1225788006439 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1225788006440 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1225788006441 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1225788006442 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1225788006443 Cupin; Region: Cupin_1; smart00835 1225788006444 Cupin; Region: Cupin_1; smart00835 1225788006445 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 1225788006446 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 1225788006447 Qo binding site; other site 1225788006448 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1225788006449 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1225788006450 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1225788006451 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1225788006452 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1225788006453 interchain domain interface [polypeptide binding]; other site 1225788006454 intrachain domain interface; other site 1225788006455 heme bH binding site [chemical binding]; other site 1225788006456 Qi binding site; other site 1225788006457 heme bL binding site [chemical binding]; other site 1225788006458 Qo binding site; other site 1225788006459 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1225788006460 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1225788006461 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1225788006462 iron-sulfur cluster [ion binding]; other site 1225788006463 [2Fe-2S] cluster binding site [ion binding]; other site 1225788006464 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1225788006465 hypothetical protein; Provisional; Region: PRK03636 1225788006466 UPF0302 domain; Region: UPF0302; pfam08864 1225788006467 A short protein domain of unknown function; Region: IDEAL; smart00914 1225788006468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1225788006469 TPR motif; other site 1225788006470 binding surface 1225788006471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1225788006472 binding surface 1225788006473 TPR motif; other site 1225788006474 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1225788006475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788006476 TPR motif; other site 1225788006477 binding surface 1225788006478 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1225788006479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788006480 binding surface 1225788006481 TPR motif; other site 1225788006482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1225788006483 binding surface 1225788006484 TPR motif; other site 1225788006485 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1225788006486 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1225788006487 hinge; other site 1225788006488 active site 1225788006489 prephenate dehydrogenase; Validated; Region: PRK06545 1225788006490 prephenate dehydrogenase; Validated; Region: PRK08507 1225788006491 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1225788006492 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1225788006493 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1225788006494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788006495 homodimer interface [polypeptide binding]; other site 1225788006496 catalytic residue [active] 1225788006497 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1225788006498 substrate binding site [chemical binding]; other site 1225788006499 active site 1225788006500 catalytic residues [active] 1225788006501 heterodimer interface [polypeptide binding]; other site 1225788006502 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1225788006503 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1225788006504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788006505 catalytic residue [active] 1225788006506 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1225788006507 active site 1225788006508 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1225788006509 active site 1225788006510 ribulose/triose binding site [chemical binding]; other site 1225788006511 phosphate binding site [ion binding]; other site 1225788006512 substrate (anthranilate) binding pocket [chemical binding]; other site 1225788006513 product (indole) binding pocket [chemical binding]; other site 1225788006514 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1225788006515 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1225788006516 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1225788006517 anthranilate synthase component I; Provisional; Region: PRK13569 1225788006518 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1225788006519 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1225788006520 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1225788006521 homotrimer interaction site [polypeptide binding]; other site 1225788006522 active site 1225788006523 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1225788006524 active site 1225788006525 dimer interface [polypeptide binding]; other site 1225788006526 metal binding site [ion binding]; metal-binding site 1225788006527 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1225788006528 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1225788006529 Tetramer interface [polypeptide binding]; other site 1225788006530 active site 1225788006531 FMN-binding site [chemical binding]; other site 1225788006532 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1225788006533 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1225788006534 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1225788006535 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1225788006536 active site 1225788006537 multimer interface [polypeptide binding]; other site 1225788006538 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1225788006539 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1225788006540 substrate binding pocket [chemical binding]; other site 1225788006541 chain length determination region; other site 1225788006542 substrate-Mg2+ binding site; other site 1225788006543 catalytic residues [active] 1225788006544 aspartate-rich region 1; other site 1225788006545 active site lid residues [active] 1225788006546 aspartate-rich region 2; other site 1225788006547 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1225788006548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788006549 S-adenosylmethionine binding site [chemical binding]; other site 1225788006550 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1225788006551 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 1225788006552 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1225788006553 homodecamer interface [polypeptide binding]; other site 1225788006554 GTP cyclohydrolase I; Provisional; Region: PLN03044 1225788006555 active site 1225788006556 putative catalytic site residues [active] 1225788006557 zinc binding site [ion binding]; other site 1225788006558 GTP-CH-I/GFRP interaction surface; other site 1225788006559 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1225788006560 IHF dimer interface [polypeptide binding]; other site 1225788006561 IHF - DNA interface [nucleotide binding]; other site 1225788006562 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1225788006563 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1225788006564 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1225788006565 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1225788006566 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1225788006567 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1225788006568 GTP-binding protein Der; Reviewed; Region: PRK00093 1225788006569 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1225788006570 G1 box; other site 1225788006571 GTP/Mg2+ binding site [chemical binding]; other site 1225788006572 Switch I region; other site 1225788006573 G2 box; other site 1225788006574 Switch II region; other site 1225788006575 G3 box; other site 1225788006576 G4 box; other site 1225788006577 G5 box; other site 1225788006578 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1225788006579 G1 box; other site 1225788006580 GTP/Mg2+ binding site [chemical binding]; other site 1225788006581 Switch I region; other site 1225788006582 G2 box; other site 1225788006583 G3 box; other site 1225788006584 Switch II region; other site 1225788006585 G4 box; other site 1225788006586 G5 box; other site 1225788006587 YpzI-like protein; Region: YpzI; pfam14140 1225788006588 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1225788006589 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1225788006590 homotetramer interface [polypeptide binding]; other site 1225788006591 FMN binding site [chemical binding]; other site 1225788006592 homodimer contacts [polypeptide binding]; other site 1225788006593 putative active site [active] 1225788006594 putative substrate binding site [chemical binding]; other site 1225788006595 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1225788006596 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1225788006597 RNA binding site [nucleotide binding]; other site 1225788006598 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1225788006599 RNA binding site [nucleotide binding]; other site 1225788006600 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1225788006601 RNA binding site [nucleotide binding]; other site 1225788006602 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1225788006603 RNA binding site [nucleotide binding]; other site 1225788006604 cytidylate kinase; Provisional; Region: cmk; PRK00023 1225788006605 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1225788006606 CMP-binding site; other site 1225788006607 The sites determining sugar specificity; other site 1225788006608 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1225788006609 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1225788006610 PilZ domain; Region: PilZ; pfam07238 1225788006611 germination protein YpeB; Region: spore_YpeB; TIGR02889 1225788006612 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1225788006613 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1225788006614 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1225788006615 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1225788006616 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1225788006617 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1225788006618 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1225788006619 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1225788006620 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1225788006621 NAD(P) binding site [chemical binding]; other site 1225788006622 adaptor protein; Provisional; Region: PRK02899 1225788006623 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1225788006624 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1225788006625 putative active site [active] 1225788006626 putative metal binding site [ion binding]; other site 1225788006627 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1225788006628 potential frameshift: common BLAST hit: gi|384265897|ref|YP_005421604.1| putative cell wall hydrolase lytN 1225788006629 CAAX protease self-immunity; Region: Abi; pfam02517 1225788006630 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1225788006631 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1225788006632 ATP binding site [chemical binding]; other site 1225788006633 putative Mg++ binding site [ion binding]; other site 1225788006634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1225788006635 nucleotide binding region [chemical binding]; other site 1225788006636 ATP-binding site [chemical binding]; other site 1225788006637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1225788006638 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1225788006639 Predicted membrane protein [Function unknown]; Region: COG3601 1225788006640 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1225788006641 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1225788006642 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1225788006643 ligand binding site [chemical binding]; other site 1225788006644 NAD binding site [chemical binding]; other site 1225788006645 dimerization interface [polypeptide binding]; other site 1225788006646 catalytic site [active] 1225788006647 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1225788006648 putative L-serine binding site [chemical binding]; other site 1225788006649 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1225788006650 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1225788006651 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1225788006652 DNA binding residues [nucleotide binding] 1225788006653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1225788006654 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1225788006655 dimerization interface [polypeptide binding]; other site 1225788006656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1225788006657 putative active site [active] 1225788006658 heme pocket [chemical binding]; other site 1225788006659 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788006660 dimer interface [polypeptide binding]; other site 1225788006661 phosphorylation site [posttranslational modification] 1225788006662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788006663 ATP binding site [chemical binding]; other site 1225788006664 Mg2+ binding site [ion binding]; other site 1225788006665 G-X-G motif; other site 1225788006666 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1225788006667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788006668 active site 1225788006669 phosphorylation site [posttranslational modification] 1225788006670 intermolecular recognition site; other site 1225788006671 dimerization interface [polypeptide binding]; other site 1225788006672 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1225788006673 DNA binding site [nucleotide binding] 1225788006674 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1225788006675 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1225788006676 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1225788006677 ResB-like family; Region: ResB; pfam05140 1225788006678 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1225788006679 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1225788006680 catalytic residues [active] 1225788006681 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1225788006682 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1225788006683 RNA binding surface [nucleotide binding]; other site 1225788006684 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1225788006685 active site 1225788006686 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1225788006687 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1225788006688 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1225788006689 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1225788006690 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1225788006691 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1225788006692 segregation and condensation protein B; Region: TIGR00281 1225788006693 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1225788006694 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1225788006695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788006696 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1225788006697 Coenzyme A binding pocket [chemical binding]; other site 1225788006698 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1225788006699 homopentamer interface [polypeptide binding]; other site 1225788006700 active site 1225788006701 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1225788006702 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1225788006703 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1225788006704 dimerization interface [polypeptide binding]; other site 1225788006705 active site 1225788006706 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1225788006707 Lumazine binding domain; Region: Lum_binding; pfam00677 1225788006708 Lumazine binding domain; Region: Lum_binding; pfam00677 1225788006709 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1225788006710 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1225788006711 catalytic motif [active] 1225788006712 Zn binding site [ion binding]; other site 1225788006713 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1225788006714 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1225788006715 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1225788006716 Catalytic site [active] 1225788006717 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1225788006718 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1225788006719 active site 1225788006720 Predicted secreted protein [Function unknown]; Region: COG4086 1225788006721 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1225788006722 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1225788006723 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1225788006724 active site 1225788006725 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1225788006726 substrate binding site [chemical binding]; other site 1225788006727 catalytic residues [active] 1225788006728 dimer interface [polypeptide binding]; other site 1225788006729 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1225788006730 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1225788006731 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1225788006732 stage V sporulation protein AD; Validated; Region: PRK08304 1225788006733 stage V sporulation protein AD; Provisional; Region: PRK12404 1225788006734 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1225788006735 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1225788006736 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1225788006737 sporulation sigma factor SigF; Validated; Region: PRK05572 1225788006738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1225788006739 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1225788006740 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1225788006741 DNA binding residues [nucleotide binding] 1225788006742 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1225788006743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788006744 ATP binding site [chemical binding]; other site 1225788006745 Mg2+ binding site [ion binding]; other site 1225788006746 G-X-G motif; other site 1225788006747 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1225788006748 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1225788006749 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1225788006750 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1225788006751 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1225788006752 phosphopentomutase; Provisional; Region: PRK05362 1225788006753 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1225788006754 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1225788006755 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1225788006756 active site 1225788006757 Int/Topo IB signature motif; other site 1225788006758 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1225788006759 ferric uptake regulator; Provisional; Region: fur; PRK09462 1225788006760 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1225788006761 metal binding site 2 [ion binding]; metal-binding site 1225788006762 putative DNA binding helix; other site 1225788006763 metal binding site 1 [ion binding]; metal-binding site 1225788006764 dimer interface [polypeptide binding]; other site 1225788006765 structural Zn2+ binding site [ion binding]; other site 1225788006766 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1225788006767 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1225788006768 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1225788006769 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1225788006770 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 1225788006771 NAD(P) binding pocket [chemical binding]; other site 1225788006772 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1225788006773 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1225788006774 Aspartase; Region: Aspartase; cd01357 1225788006775 active sites [active] 1225788006776 tetramer interface [polypeptide binding]; other site 1225788006777 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1225788006778 active site 1225788006779 homodimer interface [polypeptide binding]; other site 1225788006780 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1225788006781 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788006782 non-specific DNA binding site [nucleotide binding]; other site 1225788006783 salt bridge; other site 1225788006784 sequence-specific DNA binding site [nucleotide binding]; other site 1225788006785 TIGR00375 family protein; Region: TIGR00375 1225788006786 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1225788006787 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1225788006788 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1225788006789 dimer interface [polypeptide binding]; other site 1225788006790 ADP-ribose binding site [chemical binding]; other site 1225788006791 active site 1225788006792 nudix motif; other site 1225788006793 metal binding site [ion binding]; metal-binding site 1225788006794 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1225788006795 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1225788006796 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1225788006797 active site 1225788006798 catalytic tetrad [active] 1225788006799 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1225788006800 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1225788006801 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1225788006802 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1225788006803 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1225788006804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1225788006805 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1225788006806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788006807 Coenzyme A binding pocket [chemical binding]; other site 1225788006808 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1225788006809 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1225788006810 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1225788006811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788006812 Coenzyme A binding pocket [chemical binding]; other site 1225788006813 DNA polymerase IV; Reviewed; Region: PRK03103 1225788006814 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1225788006815 active site 1225788006816 DNA binding site [nucleotide binding] 1225788006817 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1225788006818 YolD-like protein; Region: YolD; pfam08863 1225788006819 YqzH-like protein; Region: YqzH; pfam14164 1225788006820 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1225788006821 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1225788006822 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1225788006823 putative dimer interface [polypeptide binding]; other site 1225788006824 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1225788006825 ligand binding site [chemical binding]; other site 1225788006826 Zn binding site [ion binding]; other site 1225788006827 pantothenate kinase; Provisional; Region: PRK05439 1225788006828 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1225788006829 ATP-binding site [chemical binding]; other site 1225788006830 CoA-binding site [chemical binding]; other site 1225788006831 Mg2+-binding site [ion binding]; other site 1225788006832 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1225788006833 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1225788006834 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1225788006835 catalytic residue [active] 1225788006836 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1225788006837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1225788006838 NAD(P) binding site [chemical binding]; other site 1225788006839 active site 1225788006840 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1225788006841 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1225788006842 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1225788006843 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1225788006844 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1225788006845 substrate binding site [chemical binding]; other site 1225788006846 oxyanion hole (OAH) forming residues; other site 1225788006847 trimer interface [polypeptide binding]; other site 1225788006848 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1225788006849 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1225788006850 dimer interface [polypeptide binding]; other site 1225788006851 active site 1225788006852 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1225788006853 Cytochrome P450; Region: p450; cl12078 1225788006854 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1225788006855 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1225788006856 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788006857 polyketide synthase; Region: polyketide_synthase; cd08251 1225788006858 Enoylreductase; Region: PKS_ER; smart00829 1225788006859 putative NAD(P) binding site [chemical binding]; other site 1225788006860 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788006861 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788006862 active site 1225788006863 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788006864 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788006865 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1225788006866 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788006867 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788006868 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1225788006869 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788006870 active site 1225788006871 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788006872 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788006873 putative NADP binding site [chemical binding]; other site 1225788006874 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788006875 active site 1225788006876 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788006877 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788006878 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788006879 KR domain; Region: KR; pfam08659 1225788006880 putative NADP binding site [chemical binding]; other site 1225788006881 active site 1225788006882 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788006883 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788006884 active site 1225788006885 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788006886 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788006887 putative NADP binding site [chemical binding]; other site 1225788006888 active site 1225788006889 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788006890 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788006891 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788006892 active site 1225788006893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788006894 S-adenosylmethionine binding site [chemical binding]; other site 1225788006895 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788006896 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788006897 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788006898 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788006899 active site 1225788006900 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788006901 KR domain; Region: KR; pfam08659 1225788006902 putative NADP binding site [chemical binding]; other site 1225788006903 active site 1225788006904 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788006905 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788006906 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788006907 active site 1225788006908 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788006909 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788006910 putative NADP binding site [chemical binding]; other site 1225788006911 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788006912 active site 1225788006913 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788006914 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788006915 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788006916 active site 1225788006917 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788006918 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788006919 putative NADP binding site [chemical binding]; other site 1225788006920 active site 1225788006921 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788006922 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788006923 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788006924 active site 1225788006925 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788006926 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788006927 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788006928 active site 1225788006929 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788006930 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788006931 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788006932 putative NADP binding site [chemical binding]; other site 1225788006933 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788006934 active site 1225788006935 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788006936 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788006937 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788006938 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788006939 active site 1225788006940 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788006941 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788006942 putative NADP binding site [chemical binding]; other site 1225788006943 active site 1225788006944 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788006945 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788006946 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788006947 active site 1225788006948 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788006949 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788006950 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788006951 active site 1225788006952 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788006953 putative NADP binding site [chemical binding]; other site 1225788006954 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788006955 active site 1225788006956 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1225788006957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788006958 S-adenosylmethionine binding site [chemical binding]; other site 1225788006959 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1225788006960 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788006961 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788006962 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1225788006963 active site 1225788006964 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1225788006965 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1225788006966 putative NADP binding site [chemical binding]; other site 1225788006967 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1225788006968 active site 1225788006969 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788006970 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1225788006971 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1225788006972 active site 1225788006973 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1225788006974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1225788006975 NAD(P) binding site [chemical binding]; other site 1225788006976 active site 1225788006977 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1225788006978 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1225788006979 acyl-activating enzyme (AAE) consensus motif; other site 1225788006980 active site 1225788006981 AMP binding site [chemical binding]; other site 1225788006982 CoA binding site [chemical binding]; other site 1225788006983 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1225788006984 biosynthesis cluster domain; Region: biosyn_clust_1; TIGR04098 1225788006985 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1225788006986 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1225788006987 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1225788006988 FMN binding site [chemical binding]; other site 1225788006989 substrate binding site [chemical binding]; other site 1225788006990 putative catalytic residue [active] 1225788006991 Transcription antiterminator [Transcription]; Region: NusG; COG0250 1225788006992 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 1225788006993 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788006994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788006995 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1225788006996 dimerization interface [polypeptide binding]; other site 1225788006997 GlpM protein; Region: GlpM; cl01212 1225788006998 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1225788006999 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1225788007000 active site 1225788007001 FMN binding site [chemical binding]; other site 1225788007002 substrate binding site [chemical binding]; other site 1225788007003 homotetramer interface [polypeptide binding]; other site 1225788007004 catalytic residue [active] 1225788007005 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1225788007006 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1225788007007 ribonuclease Z; Region: RNase_Z; TIGR02651 1225788007008 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1225788007009 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1225788007010 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1225788007011 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1225788007012 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1225788007013 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1225788007014 DNA polymerase IV; Validated; Region: PRK01810 1225788007015 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1225788007016 active site 1225788007017 DNA binding site [nucleotide binding] 1225788007018 OxaA-like protein precursor; Validated; Region: PRK01622 1225788007019 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1225788007020 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1225788007021 peptidase T-like protein; Region: PepT-like; TIGR01883 1225788007022 metal binding site [ion binding]; metal-binding site 1225788007023 putative dimer interface [polypeptide binding]; other site 1225788007024 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1225788007025 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1225788007026 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1225788007027 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1225788007028 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1225788007029 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1225788007030 dimer interface [polypeptide binding]; other site 1225788007031 substrate binding site [chemical binding]; other site 1225788007032 metal binding site [ion binding]; metal-binding site 1225788007033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1225788007034 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1225788007035 Predicted membrane protein [Function unknown]; Region: COG4129 1225788007036 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1225788007037 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1225788007038 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1225788007039 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1225788007040 Walker A/P-loop; other site 1225788007041 ATP binding site [chemical binding]; other site 1225788007042 Q-loop/lid; other site 1225788007043 ABC transporter signature motif; other site 1225788007044 Walker B; other site 1225788007045 D-loop; other site 1225788007046 H-loop/switch region; other site 1225788007047 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1225788007048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788007049 dimer interface [polypeptide binding]; other site 1225788007050 conserved gate region; other site 1225788007051 putative PBP binding loops; other site 1225788007052 ABC-ATPase subunit interface; other site 1225788007053 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1225788007054 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1225788007055 substrate binding pocket [chemical binding]; other site 1225788007056 membrane-bound complex binding site; other site 1225788007057 hinge residues; other site 1225788007058 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1225788007059 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1225788007060 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1225788007061 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1225788007062 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1225788007063 E3 interaction surface; other site 1225788007064 lipoyl attachment site [posttranslational modification]; other site 1225788007065 e3 binding domain; Region: E3_binding; pfam02817 1225788007066 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1225788007067 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1225788007068 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1225788007069 alpha subunit interface [polypeptide binding]; other site 1225788007070 TPP binding site [chemical binding]; other site 1225788007071 heterodimer interface [polypeptide binding]; other site 1225788007072 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1225788007073 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1225788007074 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1225788007075 tetramer interface [polypeptide binding]; other site 1225788007076 TPP-binding site [chemical binding]; other site 1225788007077 heterodimer interface [polypeptide binding]; other site 1225788007078 phosphorylation loop region [posttranslational modification] 1225788007079 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1225788007080 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1225788007081 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1225788007082 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1225788007083 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1225788007084 nucleotide binding site [chemical binding]; other site 1225788007085 Acetokinase family; Region: Acetate_kinase; cl17229 1225788007086 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4020; cl07907 1225788007087 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1225788007088 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1225788007089 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1225788007090 NAD binding site [chemical binding]; other site 1225788007091 Phe binding site; other site 1225788007092 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1225788007093 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1225788007094 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1225788007095 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1225788007096 putative active site [active] 1225788007097 heme pocket [chemical binding]; other site 1225788007098 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1225788007099 putative active site [active] 1225788007100 heme pocket [chemical binding]; other site 1225788007101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788007102 Walker A motif; other site 1225788007103 ATP binding site [chemical binding]; other site 1225788007104 Walker B motif; other site 1225788007105 arginine finger; other site 1225788007106 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1225788007107 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1225788007108 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1225788007109 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1225788007110 tetramer interface [polypeptide binding]; other site 1225788007111 active site 1225788007112 Mg2+/Mn2+ binding site [ion binding]; other site 1225788007113 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1225788007114 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1225788007115 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1225788007116 dimer interface [polypeptide binding]; other site 1225788007117 Citrate synthase; Region: Citrate_synt; pfam00285 1225788007118 active site 1225788007119 coenzyme A binding site [chemical binding]; other site 1225788007120 citrylCoA binding site [chemical binding]; other site 1225788007121 oxalacetate/citrate binding site [chemical binding]; other site 1225788007122 catalytic triad [active] 1225788007123 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1225788007124 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1225788007125 FAD binding site [chemical binding]; other site 1225788007126 homotetramer interface [polypeptide binding]; other site 1225788007127 substrate binding pocket [chemical binding]; other site 1225788007128 catalytic base [active] 1225788007129 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1225788007130 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1225788007131 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1225788007132 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1225788007133 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1225788007134 dimer interface [polypeptide binding]; other site 1225788007135 active site 1225788007136 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1225788007137 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1225788007138 active site 1225788007139 catalytic site [active] 1225788007140 metal binding site [ion binding]; metal-binding site 1225788007141 dimer interface [polypeptide binding]; other site 1225788007142 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1225788007143 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1225788007144 active site 1225788007145 metal binding site [ion binding]; metal-binding site 1225788007146 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1225788007147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788007148 sequence-specific DNA binding site [nucleotide binding]; other site 1225788007149 salt bridge; other site 1225788007150 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1225788007151 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1225788007152 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1225788007153 putative active site [active] 1225788007154 putative FMN binding site [chemical binding]; other site 1225788007155 putative substrate binding site [chemical binding]; other site 1225788007156 putative catalytic residue [active] 1225788007157 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1225788007158 alanine racemase; Region: alr; TIGR00492 1225788007159 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1225788007160 active site 1225788007161 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1225788007162 dimer interface [polypeptide binding]; other site 1225788007163 substrate binding site [chemical binding]; other site 1225788007164 catalytic residues [active] 1225788007165 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1225788007166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788007167 active site 1225788007168 phosphorylation site [posttranslational modification] 1225788007169 intermolecular recognition site; other site 1225788007170 dimerization interface [polypeptide binding]; other site 1225788007171 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1225788007172 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1225788007173 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1225788007174 protein binding site [polypeptide binding]; other site 1225788007175 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1225788007176 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1225788007177 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1225788007178 Walker A/P-loop; other site 1225788007179 ATP binding site [chemical binding]; other site 1225788007180 Q-loop/lid; other site 1225788007181 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1225788007182 ABC transporter signature motif; other site 1225788007183 Walker B; other site 1225788007184 D-loop; other site 1225788007185 H-loop/switch region; other site 1225788007186 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1225788007187 arginine repressor; Provisional; Region: PRK04280 1225788007188 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1225788007189 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1225788007190 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1225788007191 RNA binding surface [nucleotide binding]; other site 1225788007192 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1225788007193 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1225788007194 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1225788007195 TPP-binding site; other site 1225788007196 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1225788007197 PYR/PP interface [polypeptide binding]; other site 1225788007198 dimer interface [polypeptide binding]; other site 1225788007199 TPP binding site [chemical binding]; other site 1225788007200 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1225788007201 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1225788007202 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1225788007203 substrate binding pocket [chemical binding]; other site 1225788007204 chain length determination region; other site 1225788007205 substrate-Mg2+ binding site; other site 1225788007206 catalytic residues [active] 1225788007207 aspartate-rich region 1; other site 1225788007208 active site lid residues [active] 1225788007209 aspartate-rich region 2; other site 1225788007210 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1225788007211 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1225788007212 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1225788007213 generic binding surface II; other site 1225788007214 generic binding surface I; other site 1225788007215 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1225788007216 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1225788007217 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1225788007218 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1225788007219 homodimer interface [polypeptide binding]; other site 1225788007220 NADP binding site [chemical binding]; other site 1225788007221 substrate binding site [chemical binding]; other site 1225788007222 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1225788007223 putative RNA binding site [nucleotide binding]; other site 1225788007224 Asp23 family; Region: Asp23; pfam03780 1225788007225 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1225788007226 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1225788007227 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1225788007228 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1225788007229 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1225788007230 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1225788007231 carboxyltransferase (CT) interaction site; other site 1225788007232 biotinylation site [posttranslational modification]; other site 1225788007233 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1225788007234 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1225788007235 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1225788007236 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1225788007237 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1225788007238 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1225788007239 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1225788007240 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1225788007241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788007242 Walker A motif; other site 1225788007243 ATP binding site [chemical binding]; other site 1225788007244 Walker B motif; other site 1225788007245 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1225788007246 elongation factor P; Validated; Region: PRK00529 1225788007247 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1225788007248 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1225788007249 RNA binding site [nucleotide binding]; other site 1225788007250 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1225788007251 RNA binding site [nucleotide binding]; other site 1225788007252 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1225788007253 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1225788007254 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1225788007255 active site 1225788007256 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1225788007257 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1225788007258 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1225788007259 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1225788007260 active site 1225788007261 nucleophile elbow; other site 1225788007262 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1225788007263 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1225788007264 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1225788007265 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1225788007266 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1225788007267 active site residue [active] 1225788007268 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1225788007269 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1225788007270 tetramer interface [polypeptide binding]; other site 1225788007271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788007272 catalytic residue [active] 1225788007273 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1225788007274 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1225788007275 tetramer interface [polypeptide binding]; other site 1225788007276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788007277 catalytic residue [active] 1225788007278 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1225788007279 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1225788007280 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1225788007281 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1225788007282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1225788007283 ATP binding site [chemical binding]; other site 1225788007284 putative Mg++ binding site [ion binding]; other site 1225788007285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1225788007286 nucleotide binding region [chemical binding]; other site 1225788007287 ATP-binding site [chemical binding]; other site 1225788007288 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1225788007289 Anti-repressor SinI; Region: SinI; pfam08671 1225788007290 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1225788007291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788007292 non-specific DNA binding site [nucleotide binding]; other site 1225788007293 salt bridge; other site 1225788007294 sequence-specific DNA binding site [nucleotide binding]; other site 1225788007295 Anti-repressor SinI; Region: SinI; pfam08671 1225788007296 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1225788007297 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1225788007298 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1225788007299 Catalytic site [active] 1225788007300 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1225788007301 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1225788007302 YqzE-like protein; Region: YqzE; pfam14038 1225788007303 ComG operon protein 7; Region: ComGG; pfam14173 1225788007304 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1225788007305 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1225788007306 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1225788007307 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1225788007308 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1225788007309 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1225788007310 Type II/IV secretion system protein; Region: T2SE; pfam00437 1225788007311 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1225788007312 Walker A motif; other site 1225788007313 ATP binding site [chemical binding]; other site 1225788007314 Walker B motif; other site 1225788007315 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1225788007316 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1225788007317 Cl binding site [ion binding]; other site 1225788007318 oligomer interface [polypeptide binding]; other site 1225788007319 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1225788007320 Domain of unknown function DUF21; Region: DUF21; pfam01595 1225788007321 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1225788007322 Transporter associated domain; Region: CorC_HlyC; smart01091 1225788007323 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1225788007324 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1225788007325 ArsC family; Region: ArsC; pfam03960 1225788007326 putative catalytic residues [active] 1225788007327 thiol/disulfide switch; other site 1225788007328 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1225788007329 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1225788007330 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1225788007331 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1225788007332 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1225788007333 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1225788007334 putative active site [active] 1225788007335 Zn binding site [ion binding]; other site 1225788007336 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1225788007337 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1225788007338 nucleotide binding site [chemical binding]; other site 1225788007339 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1225788007340 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1225788007341 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1225788007342 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1225788007343 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1225788007344 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1225788007345 YceG-like family; Region: YceG; pfam02618 1225788007346 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1225788007347 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1225788007348 Walker A/P-loop; other site 1225788007349 ATP binding site [chemical binding]; other site 1225788007350 Q-loop/lid; other site 1225788007351 ABC transporter signature motif; other site 1225788007352 Walker B; other site 1225788007353 D-loop; other site 1225788007354 H-loop/switch region; other site 1225788007355 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1225788007356 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1225788007357 Walker A/P-loop; other site 1225788007358 ATP binding site [chemical binding]; other site 1225788007359 Q-loop/lid; other site 1225788007360 ABC transporter signature motif; other site 1225788007361 Walker B; other site 1225788007362 D-loop; other site 1225788007363 H-loop/switch region; other site 1225788007364 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1225788007365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788007366 dimer interface [polypeptide binding]; other site 1225788007367 conserved gate region; other site 1225788007368 ABC-ATPase subunit interface; other site 1225788007369 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1225788007370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788007371 dimer interface [polypeptide binding]; other site 1225788007372 conserved gate region; other site 1225788007373 putative PBP binding loops; other site 1225788007374 ABC-ATPase subunit interface; other site 1225788007375 PBP superfamily domain; Region: PBP_like_2; cl17296 1225788007376 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1225788007377 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1225788007378 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1225788007379 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1225788007380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788007381 putative substrate translocation pore; other site 1225788007382 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788007383 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1225788007384 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1225788007385 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1225788007386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1225788007387 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1225788007388 Lysin motif; Region: LysM; smart00257 1225788007389 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1225788007390 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1225788007391 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1225788007392 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1225788007393 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1225788007394 metal binding site 2 [ion binding]; metal-binding site 1225788007395 putative DNA binding helix; other site 1225788007396 metal binding site 1 [ion binding]; metal-binding site 1225788007397 dimer interface [polypeptide binding]; other site 1225788007398 structural Zn2+ binding site [ion binding]; other site 1225788007399 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1225788007400 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1225788007401 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1225788007402 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1225788007403 endonuclease IV; Provisional; Region: PRK01060 1225788007404 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1225788007405 AP (apurinic/apyrimidinic) site pocket; other site 1225788007406 DNA interaction; other site 1225788007407 Metal-binding active site; metal-binding site 1225788007408 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1225788007409 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1225788007410 ATP binding site [chemical binding]; other site 1225788007411 Mg++ binding site [ion binding]; other site 1225788007412 motif III; other site 1225788007413 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1225788007414 nucleotide binding region [chemical binding]; other site 1225788007415 ATP-binding site [chemical binding]; other site 1225788007416 YqfQ-like protein; Region: YqfQ; pfam14181 1225788007417 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1225788007418 LytB protein; Region: LYTB; pfam02401 1225788007419 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1225788007420 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1225788007421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1225788007422 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1225788007423 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1225788007424 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1225788007425 Family of unknown function (DUF633); Region: DUF633; pfam04816 1225788007426 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1225788007427 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1225788007428 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1225788007429 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1225788007430 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1225788007431 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1225788007432 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1225788007433 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1225788007434 DNA binding residues [nucleotide binding] 1225788007435 DNA primase; Validated; Region: dnaG; PRK05667 1225788007436 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1225788007437 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1225788007438 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1225788007439 active site 1225788007440 metal binding site [ion binding]; metal-binding site 1225788007441 interdomain interaction site; other site 1225788007442 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1225788007443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1225788007444 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1225788007445 HTH domain; Region: HTH_11; pfam08279 1225788007446 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1225788007447 FOG: CBS domain [General function prediction only]; Region: COG0517 1225788007448 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1225788007449 DALR anticodon binding domain; Region: DALR_1; pfam05746 1225788007450 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1225788007451 dimer interface [polypeptide binding]; other site 1225788007452 motif 1; other site 1225788007453 active site 1225788007454 motif 2; other site 1225788007455 motif 3; other site 1225788007456 Recombination protein O N terminal; Region: RecO_N; pfam11967 1225788007457 DNA repair protein RecO; Region: reco; TIGR00613 1225788007458 Recombination protein O C terminal; Region: RecO_C; pfam02565 1225788007459 YqzL-like protein; Region: YqzL; pfam14006 1225788007460 GTPase Era; Reviewed; Region: era; PRK00089 1225788007461 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1225788007462 G1 box; other site 1225788007463 GTP/Mg2+ binding site [chemical binding]; other site 1225788007464 Switch I region; other site 1225788007465 G2 box; other site 1225788007466 Switch II region; other site 1225788007467 G3 box; other site 1225788007468 G4 box; other site 1225788007469 G5 box; other site 1225788007470 KH domain; Region: KH_2; pfam07650 1225788007471 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1225788007472 active site 1225788007473 catalytic motif [active] 1225788007474 Zn binding site [ion binding]; other site 1225788007475 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1225788007476 metal-binding heat shock protein; Provisional; Region: PRK00016 1225788007477 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1225788007478 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1225788007479 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1225788007480 Zn2+ binding site [ion binding]; other site 1225788007481 Mg2+ binding site [ion binding]; other site 1225788007482 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1225788007483 PhoH-like protein; Region: PhoH; pfam02562 1225788007484 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1225788007485 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1225788007486 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1225788007487 hypothetical protein; Provisional; Region: PRK13665 1225788007488 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1225788007489 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1225788007490 dimer interface [polypeptide binding]; other site 1225788007491 active site residues [active] 1225788007492 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1225788007493 Yqey-like protein; Region: YqeY; pfam09424 1225788007494 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1225788007495 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1225788007496 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1225788007497 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1225788007498 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1225788007499 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1225788007500 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1225788007501 FeS/SAM binding site; other site 1225788007502 TRAM domain; Region: TRAM; cl01282 1225788007503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1225788007504 RNA methyltransferase, RsmE family; Region: TIGR00046 1225788007505 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1225788007506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788007507 S-adenosylmethionine binding site [chemical binding]; other site 1225788007508 chaperone protein DnaJ; Provisional; Region: PRK14280 1225788007509 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1225788007510 HSP70 interaction site [polypeptide binding]; other site 1225788007511 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1225788007512 substrate binding site [polypeptide binding]; other site 1225788007513 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1225788007514 Zn binding sites [ion binding]; other site 1225788007515 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1225788007516 dimer interface [polypeptide binding]; other site 1225788007517 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1225788007518 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1225788007519 nucleotide binding site [chemical binding]; other site 1225788007520 NEF interaction site [polypeptide binding]; other site 1225788007521 SBD interface [polypeptide binding]; other site 1225788007522 GrpE; Region: GrpE; pfam01025 1225788007523 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1225788007524 dimer interface [polypeptide binding]; other site 1225788007525 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1225788007526 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1225788007527 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1225788007528 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1225788007529 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1225788007530 FeS/SAM binding site; other site 1225788007531 HemN C-terminal domain; Region: HemN_C; pfam06969 1225788007532 GTP-binding protein LepA; Provisional; Region: PRK05433 1225788007533 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1225788007534 G1 box; other site 1225788007535 putative GEF interaction site [polypeptide binding]; other site 1225788007536 GTP/Mg2+ binding site [chemical binding]; other site 1225788007537 Switch I region; other site 1225788007538 G2 box; other site 1225788007539 G3 box; other site 1225788007540 Switch II region; other site 1225788007541 G4 box; other site 1225788007542 G5 box; other site 1225788007543 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1225788007544 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1225788007545 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1225788007546 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1225788007547 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1225788007548 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1225788007549 germination protease; Provisional; Region: PRK02858 1225788007550 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1225788007551 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1225788007552 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1225788007553 YqzM-like protein; Region: YqzM; pfam14141 1225788007554 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1225788007555 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1225788007556 Competence protein; Region: Competence; pfam03772 1225788007557 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1225788007558 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1225788007559 catalytic motif [active] 1225788007560 Zn binding site [ion binding]; other site 1225788007561 SLBB domain; Region: SLBB; pfam10531 1225788007562 comEA protein; Region: comE; TIGR01259 1225788007563 Helix-hairpin-helix motif; Region: HHH; pfam00633 1225788007564 late competence protein ComER; Validated; Region: PRK07680 1225788007565 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1225788007566 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1225788007567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788007568 S-adenosylmethionine binding site [chemical binding]; other site 1225788007569 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1225788007570 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1225788007571 Zn2+ binding site [ion binding]; other site 1225788007572 Mg2+ binding site [ion binding]; other site 1225788007573 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1225788007574 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1225788007575 active site 1225788007576 (T/H)XGH motif; other site 1225788007577 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 1225788007578 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1225788007579 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1225788007580 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1225788007581 shikimate binding site; other site 1225788007582 NAD(P) binding site [chemical binding]; other site 1225788007583 GTPase YqeH; Provisional; Region: PRK13796 1225788007584 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1225788007585 GTP/Mg2+ binding site [chemical binding]; other site 1225788007586 G4 box; other site 1225788007587 G5 box; other site 1225788007588 G1 box; other site 1225788007589 Switch I region; other site 1225788007590 G2 box; other site 1225788007591 G3 box; other site 1225788007592 Switch II region; other site 1225788007593 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1225788007594 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788007595 active site 1225788007596 motif I; other site 1225788007597 motif II; other site 1225788007598 Sporulation inhibitor A; Region: Sda; pfam08970 1225788007599 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 1225788007600 active site 1225788007601 catalytic triad [active] 1225788007602 oxyanion hole [active] 1225788007603 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1225788007604 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1225788007605 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1225788007606 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1225788007607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788007608 Coenzyme A binding pocket [chemical binding]; other site 1225788007609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788007610 H+ Antiporter protein; Region: 2A0121; TIGR00900 1225788007611 putative substrate translocation pore; other site 1225788007612 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1225788007613 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1225788007614 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1225788007615 Predicted transcriptional regulators [Transcription]; Region: COG1695 1225788007616 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1225788007617 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1225788007618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1225788007619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1225788007620 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1225788007621 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1225788007622 hypothetical protein; Validated; Region: PRK06217 1225788007623 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1225788007624 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1225788007625 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1225788007626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788007627 Coenzyme A binding pocket [chemical binding]; other site 1225788007628 DinB family; Region: DinB; pfam05163 1225788007629 DinB superfamily; Region: DinB_2; pfam12867 1225788007630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1225788007631 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1225788007632 active site 1225788007633 motif I; other site 1225788007634 motif II; other site 1225788007635 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1225788007636 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1225788007637 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1225788007638 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1225788007639 putative active site [active] 1225788007640 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1225788007641 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1225788007642 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1225788007643 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1225788007644 active site 1225788007645 P-loop; other site 1225788007646 phosphorylation site [posttranslational modification] 1225788007647 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1225788007648 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1225788007649 active site 1225788007650 phosphorylation site [posttranslational modification] 1225788007651 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1225788007652 HTH domain; Region: HTH_11; cl17392 1225788007653 PRD domain; Region: PRD; pfam00874 1225788007654 PRD domain; Region: PRD; pfam00874 1225788007655 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1225788007656 active site 1225788007657 P-loop; other site 1225788007658 phosphorylation site [posttranslational modification] 1225788007659 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1225788007660 active site 1225788007661 phosphorylation site [posttranslational modification] 1225788007662 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1225788007663 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1225788007664 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1225788007665 putative deacylase active site [active] 1225788007666 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788007667 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788007668 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1225788007669 putative dimerization interface [polypeptide binding]; other site 1225788007670 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1225788007671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788007672 putative substrate translocation pore; other site 1225788007673 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1225788007674 Cytochrome P450; Region: p450; pfam00067 1225788007675 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1225788007676 Flavodoxin; Region: Flavodoxin_1; pfam00258 1225788007677 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1225788007678 FAD binding pocket [chemical binding]; other site 1225788007679 FAD binding motif [chemical binding]; other site 1225788007680 catalytic residues [active] 1225788007681 NAD binding pocket [chemical binding]; other site 1225788007682 phosphate binding motif [ion binding]; other site 1225788007683 beta-alpha-beta structure motif; other site 1225788007684 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788007685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788007686 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1225788007687 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 1225788007688 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1225788007689 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1225788007690 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1225788007691 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1225788007692 catalytic loop [active] 1225788007693 iron binding site [ion binding]; other site 1225788007694 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1225788007695 4Fe-4S binding domain; Region: Fer4; pfam00037 1225788007696 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1225788007697 [4Fe-4S] binding site [ion binding]; other site 1225788007698 molybdopterin cofactor binding site; other site 1225788007699 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1225788007700 molybdopterin cofactor binding site; other site 1225788007701 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1225788007702 YrhC-like protein; Region: YrhC; pfam14143 1225788007703 cystathionine beta-lyase; Provisional; Region: PRK07671 1225788007704 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1225788007705 homodimer interface [polypeptide binding]; other site 1225788007706 substrate-cofactor binding pocket; other site 1225788007707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788007708 catalytic residue [active] 1225788007709 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1225788007710 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1225788007711 dimer interface [polypeptide binding]; other site 1225788007712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788007713 catalytic residue [active] 1225788007714 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1225788007715 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1225788007716 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1225788007717 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1225788007718 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1225788007719 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1225788007720 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1225788007721 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1225788007722 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1225788007723 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1225788007724 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1225788007725 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1225788007726 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1225788007727 ATP-binding site [chemical binding]; other site 1225788007728 Sugar specificity; other site 1225788007729 Pyrimidine base specificity; other site 1225788007730 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1225788007731 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1225788007732 Peptidase family U32; Region: Peptidase_U32; pfam01136 1225788007733 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1225788007734 Peptidase family U32; Region: Peptidase_U32; pfam01136 1225788007735 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1225788007736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788007737 S-adenosylmethionine binding site [chemical binding]; other site 1225788007738 conserved hypothetical protein, YceG family; Region: TIGR00247 1225788007739 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1225788007740 dimerization interface [polypeptide binding]; other site 1225788007741 hypothetical protein; Provisional; Region: PRK13678 1225788007742 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 1225788007743 hypothetical protein; Provisional; Region: PRK05473 1225788007744 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1225788007745 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1225788007746 motif 1; other site 1225788007747 active site 1225788007748 motif 2; other site 1225788007749 motif 3; other site 1225788007750 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1225788007751 DHHA1 domain; Region: DHHA1; pfam02272 1225788007752 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1225788007753 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1225788007754 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1225788007755 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1225788007756 Walker A/P-loop; other site 1225788007757 ATP binding site [chemical binding]; other site 1225788007758 Q-loop/lid; other site 1225788007759 ABC transporter signature motif; other site 1225788007760 Walker B; other site 1225788007761 D-loop; other site 1225788007762 H-loop/switch region; other site 1225788007763 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1225788007764 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1225788007765 substrate binding pocket [chemical binding]; other site 1225788007766 membrane-bound complex binding site; other site 1225788007767 hinge residues; other site 1225788007768 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1225788007769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788007770 dimer interface [polypeptide binding]; other site 1225788007771 conserved gate region; other site 1225788007772 putative PBP binding loops; other site 1225788007773 ABC-ATPase subunit interface; other site 1225788007774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788007775 dimer interface [polypeptide binding]; other site 1225788007776 conserved gate region; other site 1225788007777 putative PBP binding loops; other site 1225788007778 ABC-ATPase subunit interface; other site 1225788007779 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1225788007780 PRC-barrel domain; Region: PRC; pfam05239 1225788007781 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1225788007782 AAA domain; Region: AAA_30; pfam13604 1225788007783 Family description; Region: UvrD_C_2; pfam13538 1225788007784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788007785 binding surface 1225788007786 TPR repeat; Region: TPR_11; pfam13414 1225788007787 TPR motif; other site 1225788007788 TPR repeat; Region: TPR_11; pfam13414 1225788007789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788007790 binding surface 1225788007791 TPR motif; other site 1225788007792 TPR repeat; Region: TPR_11; pfam13414 1225788007793 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1225788007794 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1225788007795 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1225788007796 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1225788007797 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1225788007798 catalytic residue [active] 1225788007799 Predicted transcriptional regulator [Transcription]; Region: COG1959 1225788007800 Transcriptional regulator; Region: Rrf2; pfam02082 1225788007801 recombination factor protein RarA; Reviewed; Region: PRK13342 1225788007802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788007803 Walker A motif; other site 1225788007804 ATP binding site [chemical binding]; other site 1225788007805 Walker B motif; other site 1225788007806 arginine finger; other site 1225788007807 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1225788007808 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1225788007809 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1225788007810 putative ATP binding site [chemical binding]; other site 1225788007811 putative substrate interface [chemical binding]; other site 1225788007812 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1225788007813 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1225788007814 dimer interface [polypeptide binding]; other site 1225788007815 anticodon binding site; other site 1225788007816 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1225788007817 homodimer interface [polypeptide binding]; other site 1225788007818 motif 1; other site 1225788007819 active site 1225788007820 motif 2; other site 1225788007821 GAD domain; Region: GAD; pfam02938 1225788007822 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1225788007823 active site 1225788007824 motif 3; other site 1225788007825 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1225788007826 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1225788007827 dimer interface [polypeptide binding]; other site 1225788007828 motif 1; other site 1225788007829 active site 1225788007830 motif 2; other site 1225788007831 motif 3; other site 1225788007832 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1225788007833 anticodon binding site; other site 1225788007834 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1225788007835 Bacterial SH3 domain; Region: SH3_3; pfam08239 1225788007836 Bacterial SH3 domain; Region: SH3_3; pfam08239 1225788007837 Bacterial SH3 domain; Region: SH3_3; pfam08239 1225788007838 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1225788007839 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1225788007840 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1225788007841 active site 1225788007842 metal binding site [ion binding]; metal-binding site 1225788007843 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1225788007844 putative active site [active] 1225788007845 dimerization interface [polypeptide binding]; other site 1225788007846 putative tRNAtyr binding site [nucleotide binding]; other site 1225788007847 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1225788007848 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1225788007849 Zn2+ binding site [ion binding]; other site 1225788007850 Mg2+ binding site [ion binding]; other site 1225788007851 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1225788007852 synthetase active site [active] 1225788007853 NTP binding site [chemical binding]; other site 1225788007854 metal binding site [ion binding]; metal-binding site 1225788007855 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1225788007856 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1225788007857 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1225788007858 active site 1225788007859 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1225788007860 DHH family; Region: DHH; pfam01368 1225788007861 DHHA1 domain; Region: DHHA1; pfam02272 1225788007862 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1225788007863 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1225788007864 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1225788007865 TrkA-C domain; Region: TrkA_C; pfam02080 1225788007866 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1225788007867 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1225788007868 Protein export membrane protein; Region: SecD_SecF; pfam02355 1225788007869 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1225788007870 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1225788007871 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1225788007872 Predicted membrane protein [Function unknown]; Region: COG2323 1225788007873 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1225788007874 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1225788007875 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1225788007876 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1225788007877 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1225788007878 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1225788007879 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1225788007880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788007881 Walker A motif; other site 1225788007882 ATP binding site [chemical binding]; other site 1225788007883 Walker B motif; other site 1225788007884 arginine finger; other site 1225788007885 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1225788007886 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1225788007887 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1225788007888 RuvA N terminal domain; Region: RuvA_N; pfam01330 1225788007889 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1225788007890 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1225788007891 BofC C-terminal domain; Region: BofC_C; pfam08955 1225788007892 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1225788007893 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1225788007894 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788007895 quinolinate synthetase; Provisional; Region: PRK09375 1225788007896 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1225788007897 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1225788007898 dimerization interface [polypeptide binding]; other site 1225788007899 active site 1225788007900 L-aspartate oxidase; Provisional; Region: PRK08071 1225788007901 L-aspartate oxidase; Provisional; Region: PRK06175 1225788007902 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1225788007903 cysteine desulfurase; Provisional; Region: PRK02948 1225788007904 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1225788007905 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1225788007906 catalytic residue [active] 1225788007907 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1225788007908 HTH domain; Region: HTH_11; pfam08279 1225788007909 3H domain; Region: 3H; pfam02829 1225788007910 prephenate dehydratase; Provisional; Region: PRK11898 1225788007911 Prephenate dehydratase; Region: PDT; pfam00800 1225788007912 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1225788007913 putative L-Phe binding site [chemical binding]; other site 1225788007914 hypothetical protein; Provisional; Region: PRK04435 1225788007915 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1225788007916 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1225788007917 GTP1/OBG; Region: GTP1_OBG; pfam01018 1225788007918 Obg GTPase; Region: Obg; cd01898 1225788007919 G1 box; other site 1225788007920 GTP/Mg2+ binding site [chemical binding]; other site 1225788007921 Switch I region; other site 1225788007922 G2 box; other site 1225788007923 G3 box; other site 1225788007924 Switch II region; other site 1225788007925 G4 box; other site 1225788007926 G5 box; other site 1225788007927 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1225788007928 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1225788007929 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1225788007930 hypothetical protein; Provisional; Region: PRK14553 1225788007931 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1225788007932 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1225788007933 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1225788007934 Peptidase family M50; Region: Peptidase_M50; pfam02163 1225788007935 active site 1225788007936 putative substrate binding region [chemical binding]; other site 1225788007937 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1225788007938 Peptidase family M23; Region: Peptidase_M23; pfam01551 1225788007939 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1225788007940 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1225788007941 Switch I; other site 1225788007942 Switch II; other site 1225788007943 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1225788007944 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1225788007945 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1225788007946 rod shape-determining protein MreC; Region: mreC; TIGR00219 1225788007947 rod shape-determining protein MreC; Region: MreC; pfam04085 1225788007948 rod shape-determining protein MreB; Provisional; Region: PRK13927 1225788007949 MreB and similar proteins; Region: MreB_like; cd10225 1225788007950 nucleotide binding site [chemical binding]; other site 1225788007951 Mg binding site [ion binding]; other site 1225788007952 putative protofilament interaction site [polypeptide binding]; other site 1225788007953 RodZ interaction site [polypeptide binding]; other site 1225788007954 hypothetical protein; Reviewed; Region: PRK00024 1225788007955 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1225788007956 MPN+ (JAMM) motif; other site 1225788007957 Zinc-binding site [ion binding]; other site 1225788007958 Maf-like protein; Region: Maf; pfam02545 1225788007959 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1225788007960 active site 1225788007961 dimer interface [polypeptide binding]; other site 1225788007962 Sporulation related domain; Region: SPOR; pfam05036 1225788007963 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1225788007964 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1225788007965 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1225788007966 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1225788007967 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1225788007968 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1225788007969 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1225788007970 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1225788007971 active site 1225788007972 HIGH motif; other site 1225788007973 nucleotide binding site [chemical binding]; other site 1225788007974 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1225788007975 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1225788007976 active site 1225788007977 KMSKS motif; other site 1225788007978 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1225788007979 tRNA binding surface [nucleotide binding]; other site 1225788007980 anticodon binding site; other site 1225788007981 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1225788007982 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1225788007983 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1225788007984 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1225788007985 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1225788007986 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1225788007987 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1225788007988 inhibitor-cofactor binding pocket; inhibition site 1225788007989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788007990 catalytic residue [active] 1225788007991 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1225788007992 dimer interface [polypeptide binding]; other site 1225788007993 active site 1225788007994 Schiff base residues; other site 1225788007995 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1225788007996 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1225788007997 active site 1225788007998 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1225788007999 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1225788008000 domain interfaces; other site 1225788008001 active site 1225788008002 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 1225788008003 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1225788008004 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1225788008005 tRNA; other site 1225788008006 putative tRNA binding site [nucleotide binding]; other site 1225788008007 putative NADP binding site [chemical binding]; other site 1225788008008 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1225788008009 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1225788008010 GTP/Mg2+ binding site [chemical binding]; other site 1225788008011 Switch I region; other site 1225788008012 G2 box; other site 1225788008013 G3 box; other site 1225788008014 Switch II region; other site 1225788008015 G4 box; other site 1225788008016 G5 box; other site 1225788008017 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1225788008018 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1225788008019 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1225788008020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788008021 Walker A motif; other site 1225788008022 ATP binding site [chemical binding]; other site 1225788008023 Walker B motif; other site 1225788008024 arginine finger; other site 1225788008025 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1225788008026 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1225788008027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788008028 Walker A motif; other site 1225788008029 ATP binding site [chemical binding]; other site 1225788008030 Walker B motif; other site 1225788008031 arginine finger; other site 1225788008032 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1225788008033 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1225788008034 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1225788008035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788008036 Walker A motif; other site 1225788008037 ATP binding site [chemical binding]; other site 1225788008038 Walker B motif; other site 1225788008039 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1225788008040 trigger factor; Provisional; Region: tig; PRK01490 1225788008041 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1225788008042 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1225788008043 TPR repeat; Region: TPR_11; pfam13414 1225788008044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788008045 binding surface 1225788008046 TPR motif; other site 1225788008047 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1225788008048 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1225788008049 substrate binding site [chemical binding]; other site 1225788008050 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1225788008051 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1225788008052 substrate binding site [chemical binding]; other site 1225788008053 ligand binding site [chemical binding]; other site 1225788008054 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1225788008055 tartrate dehydrogenase; Region: TTC; TIGR02089 1225788008056 2-isopropylmalate synthase; Validated; Region: PRK00915 1225788008057 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1225788008058 active site 1225788008059 catalytic residues [active] 1225788008060 metal binding site [ion binding]; metal-binding site 1225788008061 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1225788008062 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1225788008063 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1225788008064 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1225788008065 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1225788008066 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1225788008067 putative valine binding site [chemical binding]; other site 1225788008068 dimer interface [polypeptide binding]; other site 1225788008069 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1225788008070 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1225788008071 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1225788008072 PYR/PP interface [polypeptide binding]; other site 1225788008073 dimer interface [polypeptide binding]; other site 1225788008074 TPP binding site [chemical binding]; other site 1225788008075 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1225788008076 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1225788008077 TPP-binding site [chemical binding]; other site 1225788008078 dimer interface [polypeptide binding]; other site 1225788008079 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1225788008080 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1225788008081 active site 1225788008082 metal binding site [ion binding]; metal-binding site 1225788008083 homotetramer interface [polypeptide binding]; other site 1225788008084 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1225788008085 active site 1225788008086 dimerization interface [polypeptide binding]; other site 1225788008087 ribonuclease PH; Reviewed; Region: rph; PRK00173 1225788008088 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1225788008089 hexamer interface [polypeptide binding]; other site 1225788008090 active site 1225788008091 Sporulation and spore germination; Region: Germane; pfam10646 1225788008092 Spore germination protein [General function prediction only]; Region: COG5401 1225788008093 Sporulation and spore germination; Region: Germane; pfam10646 1225788008094 glutamate racemase; Provisional; Region: PRK00865 1225788008095 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788008096 MarR family; Region: MarR; pfam01047 1225788008097 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1225788008098 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1225788008099 DNA binding residues [nucleotide binding] 1225788008100 dimerization interface [polypeptide binding]; other site 1225788008101 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1225788008102 active site 1225788008103 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1225788008104 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1225788008105 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1225788008106 L-aspartate oxidase; Provisional; Region: PRK06175 1225788008107 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1225788008108 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1225788008109 putative Iron-sulfur protein interface [polypeptide binding]; other site 1225788008110 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1225788008111 proximal heme binding site [chemical binding]; other site 1225788008112 distal heme binding site [chemical binding]; other site 1225788008113 putative dimer interface [polypeptide binding]; other site 1225788008114 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1225788008115 aspartate kinase; Reviewed; Region: PRK06635 1225788008116 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1225788008117 nucleotide binding site [chemical binding]; other site 1225788008118 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1225788008119 putative allosteric regulatory site; other site 1225788008120 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1225788008121 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1225788008122 nucleotide binding site [chemical binding]; other site 1225788008123 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1225788008124 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1225788008125 GIY-YIG motif/motif A; other site 1225788008126 active site 1225788008127 catalytic site [active] 1225788008128 putative DNA binding site [nucleotide binding]; other site 1225788008129 metal binding site [ion binding]; metal-binding site 1225788008130 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1225788008131 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1225788008132 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1225788008133 catalytic residues [active] 1225788008134 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1225788008135 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1225788008136 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1225788008137 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1225788008138 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1225788008139 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1225788008140 Ligand binding site [chemical binding]; other site 1225788008141 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1225788008142 enoyl-CoA hydratase; Provisional; Region: PRK07658 1225788008143 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1225788008144 substrate binding site [chemical binding]; other site 1225788008145 oxyanion hole (OAH) forming residues; other site 1225788008146 trimer interface [polypeptide binding]; other site 1225788008147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788008148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788008149 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1225788008150 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1225788008151 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1225788008152 acyl-activating enzyme (AAE) consensus motif; other site 1225788008153 putative AMP binding site [chemical binding]; other site 1225788008154 putative active site [active] 1225788008155 putative CoA binding site [chemical binding]; other site 1225788008156 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1225788008157 Predicted membrane protein [Function unknown]; Region: COG3766 1225788008158 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1225788008159 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1225788008160 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1225788008161 MutS domain III; Region: MutS_III; pfam05192 1225788008162 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1225788008163 Walker A/P-loop; other site 1225788008164 ATP binding site [chemical binding]; other site 1225788008165 Q-loop/lid; other site 1225788008166 ABC transporter signature motif; other site 1225788008167 Walker B; other site 1225788008168 D-loop; other site 1225788008169 H-loop/switch region; other site 1225788008170 Smr domain; Region: Smr; pfam01713 1225788008171 potential frameshift: common BLAST hit: gi|387899449|ref|YP_006329745.1| DNA polymerase 1225788008172 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1225788008173 Colicin V production protein; Region: Colicin_V; pfam02674 1225788008174 cell division protein ZapA; Provisional; Region: PRK14126 1225788008175 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1225788008176 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1225788008177 active site 1225788008178 RNA/DNA hybrid binding site [nucleotide binding]; other site 1225788008179 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1225788008180 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1225788008181 putative tRNA-binding site [nucleotide binding]; other site 1225788008182 B3/4 domain; Region: B3_4; pfam03483 1225788008183 tRNA synthetase B5 domain; Region: B5; smart00874 1225788008184 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1225788008185 dimer interface [polypeptide binding]; other site 1225788008186 motif 1; other site 1225788008187 motif 3; other site 1225788008188 motif 2; other site 1225788008189 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1225788008190 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1225788008191 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1225788008192 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1225788008193 dimer interface [polypeptide binding]; other site 1225788008194 motif 1; other site 1225788008195 active site 1225788008196 motif 2; other site 1225788008197 motif 3; other site 1225788008198 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1225788008199 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1225788008200 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1225788008201 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1225788008202 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1225788008203 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1225788008204 FAD binding domain; Region: FAD_binding_4; pfam01565 1225788008205 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1225788008206 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1225788008207 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1225788008208 Cysteine-rich domain; Region: CCG; pfam02754 1225788008209 Cysteine-rich domain; Region: CCG; pfam02754 1225788008210 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1225788008211 Carbon starvation protein CstA; Region: CstA; pfam02554 1225788008212 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1225788008213 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1225788008214 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1225788008215 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1225788008216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788008217 putative PBP binding loops; other site 1225788008218 dimer interface [polypeptide binding]; other site 1225788008219 ABC-ATPase subunit interface; other site 1225788008220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788008221 dimer interface [polypeptide binding]; other site 1225788008222 conserved gate region; other site 1225788008223 putative PBP binding loops; other site 1225788008224 ABC-ATPase subunit interface; other site 1225788008225 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1225788008226 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1225788008227 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1225788008228 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1225788008229 active site 1225788008230 metal binding site [ion binding]; metal-binding site 1225788008231 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 1225788008232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788008233 active site 1225788008234 motif I; other site 1225788008235 motif II; other site 1225788008236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788008237 motif II; other site 1225788008238 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1225788008239 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1225788008240 intersubunit interface [polypeptide binding]; other site 1225788008241 active site 1225788008242 Zn2+ binding site [ion binding]; other site 1225788008243 ribulokinase; Provisional; Region: PRK04123 1225788008244 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1225788008245 N- and C-terminal domain interface [polypeptide binding]; other site 1225788008246 active site 1225788008247 MgATP binding site [chemical binding]; other site 1225788008248 catalytic site [active] 1225788008249 metal binding site [ion binding]; metal-binding site 1225788008250 carbohydrate binding site [chemical binding]; other site 1225788008251 homodimer interface [polypeptide binding]; other site 1225788008252 L-arabinose isomerase; Provisional; Region: PRK02929 1225788008253 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1225788008254 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1225788008255 trimer interface [polypeptide binding]; other site 1225788008256 putative substrate binding site [chemical binding]; other site 1225788008257 putative metal binding site [ion binding]; other site 1225788008258 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1225788008259 substrate binding site [chemical binding]; other site 1225788008260 active site 1225788008261 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1225788008262 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1225788008263 oligomer interface [polypeptide binding]; other site 1225788008264 active site 1225788008265 metal binding site [ion binding]; metal-binding site 1225788008266 Predicted membrane protein [Function unknown]; Region: COG3326 1225788008267 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1225788008268 23S rRNA binding site [nucleotide binding]; other site 1225788008269 L21 binding site [polypeptide binding]; other site 1225788008270 L13 binding site [polypeptide binding]; other site 1225788008271 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1225788008272 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1225788008273 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1225788008274 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1225788008275 antiholin-like protein LrgB; Provisional; Region: PRK04288 1225788008276 LrgA family; Region: LrgA; cl00608 1225788008277 two-component response regulator; Provisional; Region: PRK14084 1225788008278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788008279 active site 1225788008280 phosphorylation site [posttranslational modification] 1225788008281 intermolecular recognition site; other site 1225788008282 dimerization interface [polypeptide binding]; other site 1225788008283 LytTr DNA-binding domain; Region: LytTR; smart00850 1225788008284 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1225788008285 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1225788008286 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1225788008287 Histidine kinase; Region: His_kinase; pfam06580 1225788008288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788008289 ATP binding site [chemical binding]; other site 1225788008290 Mg2+ binding site [ion binding]; other site 1225788008291 G-X-G motif; other site 1225788008292 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1225788008293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788008294 motif II; other site 1225788008295 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1225788008296 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1225788008297 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1225788008298 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1225788008299 active site 1225788008300 dimer interface [polypeptide binding]; other site 1225788008301 motif 1; other site 1225788008302 motif 2; other site 1225788008303 motif 3; other site 1225788008304 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1225788008305 anticodon binding site; other site 1225788008306 YtxC-like family; Region: YtxC; pfam08812 1225788008307 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1225788008308 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1225788008309 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1225788008310 primosomal protein DnaI; Reviewed; Region: PRK08939 1225788008311 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1225788008312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1225788008313 Walker A motif; other site 1225788008314 ATP binding site [chemical binding]; other site 1225788008315 Walker B motif; other site 1225788008316 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1225788008317 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1225788008318 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1225788008319 ATP cone domain; Region: ATP-cone; pfam03477 1225788008320 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1225788008321 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1225788008322 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1225788008323 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1225788008324 Predicted transcriptional regulators [Transcription]; Region: COG1733 1225788008325 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1225788008326 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1225788008327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788008328 putative substrate translocation pore; other site 1225788008329 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1225788008330 active site 1225788008331 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1225788008332 catalytic tetrad [active] 1225788008333 dephospho-CoA kinase; Region: TIGR00152 1225788008334 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1225788008335 CoA-binding site [chemical binding]; other site 1225788008336 ATP-binding [chemical binding]; other site 1225788008337 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1225788008338 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1225788008339 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1225788008340 DNA binding site [nucleotide binding] 1225788008341 catalytic residue [active] 1225788008342 H2TH interface [polypeptide binding]; other site 1225788008343 putative catalytic residues [active] 1225788008344 turnover-facilitating residue; other site 1225788008345 intercalation triad [nucleotide binding]; other site 1225788008346 8OG recognition residue [nucleotide binding]; other site 1225788008347 putative reading head residues; other site 1225788008348 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1225788008349 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1225788008350 DNA polymerase I; Provisional; Region: PRK05755 1225788008351 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1225788008352 active site 1225788008353 metal binding site 1 [ion binding]; metal-binding site 1225788008354 putative 5' ssDNA interaction site; other site 1225788008355 metal binding site 3; metal-binding site 1225788008356 metal binding site 2 [ion binding]; metal-binding site 1225788008357 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1225788008358 putative DNA binding site [nucleotide binding]; other site 1225788008359 putative metal binding site [ion binding]; other site 1225788008360 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1225788008361 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1225788008362 active site 1225788008363 DNA binding site [nucleotide binding] 1225788008364 catalytic site [active] 1225788008365 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1225788008366 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1225788008367 putative active site [active] 1225788008368 heme pocket [chemical binding]; other site 1225788008369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788008370 dimer interface [polypeptide binding]; other site 1225788008371 phosphorylation site [posttranslational modification] 1225788008372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788008373 ATP binding site [chemical binding]; other site 1225788008374 Mg2+ binding site [ion binding]; other site 1225788008375 G-X-G motif; other site 1225788008376 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1225788008377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788008378 active site 1225788008379 phosphorylation site [posttranslational modification] 1225788008380 intermolecular recognition site; other site 1225788008381 dimerization interface [polypeptide binding]; other site 1225788008382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1225788008383 DNA binding site [nucleotide binding] 1225788008384 malate dehydrogenase; Reviewed; Region: PRK06223 1225788008385 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1225788008386 NAD(P) binding site [chemical binding]; other site 1225788008387 dimer interface [polypeptide binding]; other site 1225788008388 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1225788008389 substrate binding site [chemical binding]; other site 1225788008390 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1225788008391 isocitrate dehydrogenase; Validated; Region: PRK07362 1225788008392 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1225788008393 dimer interface [polypeptide binding]; other site 1225788008394 Citrate synthase; Region: Citrate_synt; pfam00285 1225788008395 active site 1225788008396 citrylCoA binding site [chemical binding]; other site 1225788008397 oxalacetate/citrate binding site [chemical binding]; other site 1225788008398 coenzyme A binding site [chemical binding]; other site 1225788008399 catalytic triad [active] 1225788008400 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1225788008401 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1225788008402 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 1225788008403 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1225788008404 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1225788008405 pyruvate kinase; Provisional; Region: PRK06354 1225788008406 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1225788008407 domain interfaces; other site 1225788008408 active site 1225788008409 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1225788008410 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1225788008411 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1225788008412 active site 1225788008413 ADP/pyrophosphate binding site [chemical binding]; other site 1225788008414 dimerization interface [polypeptide binding]; other site 1225788008415 allosteric effector site; other site 1225788008416 fructose-1,6-bisphosphate binding site; other site 1225788008417 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1225788008418 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1225788008419 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1225788008420 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1225788008421 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1225788008422 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1225788008423 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1225788008424 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1225788008425 putative NAD(P) binding site [chemical binding]; other site 1225788008426 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1225788008427 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1225788008428 active site 1225788008429 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1225788008430 generic binding surface I; other site 1225788008431 generic binding surface II; other site 1225788008432 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1225788008433 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1225788008434 DHH family; Region: DHH; pfam01368 1225788008435 DHHA1 domain; Region: DHHA1; pfam02272 1225788008436 YtpI-like protein; Region: YtpI; pfam14007 1225788008437 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1225788008438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788008439 DNA-binding site [nucleotide binding]; DNA binding site 1225788008440 DRTGG domain; Region: DRTGG; pfam07085 1225788008441 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1225788008442 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1225788008443 active site 2 [active] 1225788008444 active site 1 [active] 1225788008445 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1225788008446 metal-dependent hydrolase; Provisional; Region: PRK00685 1225788008447 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1225788008448 classical (c) SDRs; Region: SDR_c; cd05233 1225788008449 NAD(P) binding site [chemical binding]; other site 1225788008450 active site 1225788008451 argininosuccinate lyase; Provisional; Region: PRK00855 1225788008452 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1225788008453 active sites [active] 1225788008454 tetramer interface [polypeptide binding]; other site 1225788008455 argininosuccinate synthase; Provisional; Region: PRK13820 1225788008456 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1225788008457 ANP binding site [chemical binding]; other site 1225788008458 Substrate Binding Site II [chemical binding]; other site 1225788008459 Substrate Binding Site I [chemical binding]; other site 1225788008460 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1225788008461 MPT binding site; other site 1225788008462 trimer interface [polypeptide binding]; other site 1225788008463 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1225788008464 propionate/acetate kinase; Provisional; Region: PRK12379 1225788008465 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1225788008466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788008467 S-adenosylmethionine binding site [chemical binding]; other site 1225788008468 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1225788008469 dimer interface [polypeptide binding]; other site 1225788008470 catalytic triad [active] 1225788008471 peroxidatic and resolving cysteines [active] 1225788008472 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 1225788008473 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1225788008474 RDD family; Region: RDD; pfam06271 1225788008475 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1225788008476 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1225788008477 tandem repeat interface [polypeptide binding]; other site 1225788008478 oligomer interface [polypeptide binding]; other site 1225788008479 active site residues [active] 1225788008480 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1225788008481 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1225788008482 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1225788008483 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1225788008484 active site 1225788008485 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1225788008486 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1225788008487 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1225788008488 active site 1225788008489 acyl-activating enzyme (AAE) consensus motif; other site 1225788008490 putative CoA binding site [chemical binding]; other site 1225788008491 AMP binding site [chemical binding]; other site 1225788008492 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1225788008493 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1225788008494 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1225788008495 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1225788008496 Ligand Binding Site [chemical binding]; other site 1225788008497 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1225788008498 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1225788008499 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1225788008500 catalytic residue [active] 1225788008501 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1225788008502 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1225788008503 TMPIT-like protein; Region: TMPIT; pfam07851 1225788008504 histidinol-phosphatase; Reviewed; Region: PRK08123 1225788008505 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1225788008506 active site 1225788008507 dimer interface [polypeptide binding]; other site 1225788008508 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788008509 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788008510 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1225788008511 GAF domain; Region: GAF_2; pfam13185 1225788008512 GAF domain; Region: GAF_3; pfam13492 1225788008513 GAF domain; Region: GAF_2; pfam13185 1225788008514 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1225788008515 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1225788008516 metal binding site [ion binding]; metal-binding site 1225788008517 active site 1225788008518 I-site; other site 1225788008519 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1225788008520 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1225788008521 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1225788008522 RNA binding surface [nucleotide binding]; other site 1225788008523 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1225788008524 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1225788008525 NAD(P) binding site [chemical binding]; other site 1225788008526 catalytic residues [active] 1225788008527 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1225788008528 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1225788008529 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1225788008530 heme-binding site [chemical binding]; other site 1225788008531 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1225788008532 FAD binding pocket [chemical binding]; other site 1225788008533 FAD binding motif [chemical binding]; other site 1225788008534 phosphate binding motif [ion binding]; other site 1225788008535 beta-alpha-beta structure motif; other site 1225788008536 NAD binding pocket [chemical binding]; other site 1225788008537 Heme binding pocket [chemical binding]; other site 1225788008538 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1225788008539 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1225788008540 proposed catalytic triad [active] 1225788008541 conserved cys residue [active] 1225788008542 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1225788008543 active site 1225788008544 catalytic triad [active] 1225788008545 oxyanion hole [active] 1225788008546 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1225788008547 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1225788008548 Predicted transcriptional regulators [Transcription]; Region: COG1378 1225788008549 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1225788008550 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1225788008551 C-terminal domain interface [polypeptide binding]; other site 1225788008552 sugar binding site [chemical binding]; other site 1225788008553 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1225788008554 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1225788008555 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1225788008556 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1225788008557 active site 1225788008558 HIGH motif; other site 1225788008559 dimer interface [polypeptide binding]; other site 1225788008560 KMSKS motif; other site 1225788008561 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1225788008562 RNA binding surface [nucleotide binding]; other site 1225788008563 acetyl-CoA synthetase; Provisional; Region: PRK04319 1225788008564 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1225788008565 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1225788008566 active site 1225788008567 acyl-activating enzyme (AAE) consensus motif; other site 1225788008568 putative CoA binding site [chemical binding]; other site 1225788008569 AMP binding site [chemical binding]; other site 1225788008570 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788008571 Coenzyme A binding pocket [chemical binding]; other site 1225788008572 FOG: CBS domain [General function prediction only]; Region: COG0517 1225788008573 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1225788008574 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1225788008575 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1225788008576 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1225788008577 active site 1225788008578 Zn binding site [ion binding]; other site 1225788008579 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1225788008580 flagellar motor protein MotS; Reviewed; Region: PRK06925 1225788008581 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1225788008582 ligand binding site [chemical binding]; other site 1225788008583 flagellar motor protein MotP; Reviewed; Region: PRK06926 1225788008584 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1225788008585 catabolite control protein A; Region: ccpA; TIGR01481 1225788008586 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1225788008587 DNA binding site [nucleotide binding] 1225788008588 domain linker motif; other site 1225788008589 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1225788008590 dimerization interface [polypeptide binding]; other site 1225788008591 effector binding site; other site 1225788008592 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1225788008593 Chorismate mutase type II; Region: CM_2; cl00693 1225788008594 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1225788008595 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 1225788008596 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1225788008597 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1225788008598 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1225788008599 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1225788008600 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1225788008601 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1225788008602 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1225788008603 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1225788008604 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1225788008605 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1225788008606 putative tRNA-binding site [nucleotide binding]; other site 1225788008607 hypothetical protein; Provisional; Region: PRK13668 1225788008608 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1225788008609 catalytic residues [active] 1225788008610 YtoQ family protein; Region: YtoQ_fam; TIGR03646 1225788008611 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1225788008612 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1225788008613 oligomer interface [polypeptide binding]; other site 1225788008614 active site 1225788008615 metal binding site [ion binding]; metal-binding site 1225788008616 Predicted small secreted protein [Function unknown]; Region: COG5584 1225788008617 malate dehydrogenase; Provisional; Region: PRK13529 1225788008618 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1225788008619 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1225788008620 NAD(P) binding site [chemical binding]; other site 1225788008621 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1225788008622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788008623 S-adenosylmethionine binding site [chemical binding]; other site 1225788008624 YtzH-like protein; Region: YtzH; pfam14165 1225788008625 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1225788008626 active site 1225788008627 ATP binding site [chemical binding]; other site 1225788008628 Phosphotransferase enzyme family; Region: APH; pfam01636 1225788008629 substrate binding site [chemical binding]; other site 1225788008630 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1225788008631 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1225788008632 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1225788008633 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1225788008634 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1225788008635 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1225788008636 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1225788008637 dimer interface [polypeptide binding]; other site 1225788008638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788008639 catalytic residue [active] 1225788008640 dipeptidase PepV; Reviewed; Region: PRK07318 1225788008641 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1225788008642 active site 1225788008643 metal binding site [ion binding]; metal-binding site 1225788008644 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1225788008645 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1225788008646 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1225788008647 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1225788008648 Walker A/P-loop; other site 1225788008649 ATP binding site [chemical binding]; other site 1225788008650 Q-loop/lid; other site 1225788008651 ABC transporter signature motif; other site 1225788008652 Walker B; other site 1225788008653 D-loop; other site 1225788008654 H-loop/switch region; other site 1225788008655 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1225788008656 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1225788008657 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1225788008658 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1225788008659 RNA binding surface [nucleotide binding]; other site 1225788008660 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1225788008661 active site 1225788008662 uracil binding [chemical binding]; other site 1225788008663 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1225788008664 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1225788008665 HI0933-like protein; Region: HI0933_like; pfam03486 1225788008666 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1225788008667 BCCT family transporter; Region: BCCT; pfam02028 1225788008668 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1225788008669 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1225788008670 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1225788008671 DNA binding site [nucleotide binding] 1225788008672 domain linker motif; other site 1225788008673 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1225788008674 putative ligand binding site [chemical binding]; other site 1225788008675 putative dimerization interface [polypeptide binding]; other site 1225788008676 PBP superfamily domain; Region: PBP_like_2; cl17296 1225788008677 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1225788008678 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1225788008679 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1225788008680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788008681 dimer interface [polypeptide binding]; other site 1225788008682 conserved gate region; other site 1225788008683 putative PBP binding loops; other site 1225788008684 ABC-ATPase subunit interface; other site 1225788008685 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1225788008686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788008687 dimer interface [polypeptide binding]; other site 1225788008688 conserved gate region; other site 1225788008689 putative PBP binding loops; other site 1225788008690 ABC-ATPase subunit interface; other site 1225788008691 alpha-galactosidase; Provisional; Region: PRK15076 1225788008692 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1225788008693 NAD binding site [chemical binding]; other site 1225788008694 sugar binding site [chemical binding]; other site 1225788008695 divalent metal binding site [ion binding]; other site 1225788008696 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1225788008697 dimer interface [polypeptide binding]; other site 1225788008698 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1225788008699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788008700 Coenzyme A binding pocket [chemical binding]; other site 1225788008701 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1225788008702 active site residue [active] 1225788008703 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1225788008704 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1225788008705 HIGH motif; other site 1225788008706 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1225788008707 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1225788008708 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1225788008709 active site 1225788008710 KMSKS motif; other site 1225788008711 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1225788008712 tRNA binding surface [nucleotide binding]; other site 1225788008713 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1225788008714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1225788008715 PAS domain; Region: PAS_9; pfam13426 1225788008716 putative active site [active] 1225788008717 heme pocket [chemical binding]; other site 1225788008718 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1225788008719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788008720 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788008721 putative substrate translocation pore; other site 1225788008722 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 1225788008723 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1225788008724 FtsX-like permease family; Region: FtsX; pfam02687 1225788008725 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1225788008726 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1225788008727 Walker A/P-loop; other site 1225788008728 ATP binding site [chemical binding]; other site 1225788008729 Q-loop/lid; other site 1225788008730 ABC transporter signature motif; other site 1225788008731 Walker B; other site 1225788008732 D-loop; other site 1225788008733 H-loop/switch region; other site 1225788008734 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1225788008735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1225788008736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788008737 ATP binding site [chemical binding]; other site 1225788008738 Mg2+ binding site [ion binding]; other site 1225788008739 G-X-G motif; other site 1225788008740 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1225788008741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788008742 active site 1225788008743 phosphorylation site [posttranslational modification] 1225788008744 intermolecular recognition site; other site 1225788008745 dimerization interface [polypeptide binding]; other site 1225788008746 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1225788008747 DNA binding site [nucleotide binding] 1225788008748 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1225788008749 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1225788008750 FtsX-like permease family; Region: FtsX; pfam02687 1225788008751 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1225788008752 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1225788008753 Walker A/P-loop; other site 1225788008754 ATP binding site [chemical binding]; other site 1225788008755 Q-loop/lid; other site 1225788008756 ABC transporter signature motif; other site 1225788008757 Walker B; other site 1225788008758 D-loop; other site 1225788008759 H-loop/switch region; other site 1225788008760 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1225788008761 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1225788008762 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1225788008763 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1225788008764 Walker A/P-loop; other site 1225788008765 ATP binding site [chemical binding]; other site 1225788008766 Q-loop/lid; other site 1225788008767 ABC transporter signature motif; other site 1225788008768 Walker B; other site 1225788008769 D-loop; other site 1225788008770 H-loop/switch region; other site 1225788008771 Predicted transcriptional regulators [Transcription]; Region: COG1725 1225788008772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788008773 DNA-binding site [nucleotide binding]; DNA binding site 1225788008774 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1225788008775 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1225788008776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788008777 S-adenosylmethionine binding site [chemical binding]; other site 1225788008778 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1225788008779 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1225788008780 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1225788008781 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1225788008782 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1225788008783 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1225788008784 trimer interface [polypeptide binding]; other site 1225788008785 putative metal binding site [ion binding]; other site 1225788008786 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1225788008787 Spore germination protein; Region: Spore_permease; cl17796 1225788008788 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1225788008789 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1225788008790 active site 1225788008791 dimer interface [polypeptide binding]; other site 1225788008792 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1225788008793 Ligand Binding Site [chemical binding]; other site 1225788008794 Molecular Tunnel; other site 1225788008795 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1225788008796 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1225788008797 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1225788008798 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1225788008799 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1225788008800 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1225788008801 active site 1225788008802 substrate-binding site [chemical binding]; other site 1225788008803 metal-binding site [ion binding] 1225788008804 ATP binding site [chemical binding]; other site 1225788008805 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1225788008806 Dienelactone hydrolase family; Region: DLH; pfam01738 1225788008807 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1225788008808 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1225788008809 NMT1-like family; Region: NMT1_2; pfam13379 1225788008810 substrate binding pocket [chemical binding]; other site 1225788008811 membrane-bound complex binding site; other site 1225788008812 hinge residues; other site 1225788008813 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1225788008814 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1225788008815 Walker A/P-loop; other site 1225788008816 ATP binding site [chemical binding]; other site 1225788008817 Q-loop/lid; other site 1225788008818 ABC transporter signature motif; other site 1225788008819 Walker B; other site 1225788008820 D-loop; other site 1225788008821 H-loop/switch region; other site 1225788008822 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1225788008823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788008824 dimer interface [polypeptide binding]; other site 1225788008825 conserved gate region; other site 1225788008826 putative PBP binding loops; other site 1225788008827 ABC-ATPase subunit interface; other site 1225788008828 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1225788008829 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1225788008830 nudix motif; other site 1225788008831 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1225788008832 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1225788008833 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1225788008834 dimerization interface [polypeptide binding]; other site 1225788008835 DPS ferroxidase diiron center [ion binding]; other site 1225788008836 ion pore; other site 1225788008837 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 1225788008838 YtkA-like; Region: YtkA; pfam13115 1225788008839 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1225788008840 Haemolytic domain; Region: Haemolytic; pfam01809 1225788008841 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1225788008842 active site clefts [active] 1225788008843 zinc binding site [ion binding]; other site 1225788008844 dimer interface [polypeptide binding]; other site 1225788008845 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1225788008846 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1225788008847 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1225788008848 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1225788008849 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1225788008850 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1225788008851 active site 1225788008852 octamer interface [polypeptide binding]; other site 1225788008853 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1225788008854 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1225788008855 acyl-activating enzyme (AAE) consensus motif; other site 1225788008856 putative AMP binding site [chemical binding]; other site 1225788008857 putative active site [active] 1225788008858 putative CoA binding site [chemical binding]; other site 1225788008859 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1225788008860 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1225788008861 substrate binding site [chemical binding]; other site 1225788008862 oxyanion hole (OAH) forming residues; other site 1225788008863 trimer interface [polypeptide binding]; other site 1225788008864 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1225788008865 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1225788008866 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1225788008867 dimer interface [polypeptide binding]; other site 1225788008868 tetramer interface [polypeptide binding]; other site 1225788008869 PYR/PP interface [polypeptide binding]; other site 1225788008870 TPP binding site [chemical binding]; other site 1225788008871 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1225788008872 TPP-binding site; other site 1225788008873 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1225788008874 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1225788008875 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1225788008876 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 1225788008877 Predicted membrane protein [Function unknown]; Region: COG3859 1225788008878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1225788008879 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1225788008880 DinB superfamily; Region: DinB_2; pfam12867 1225788008881 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1225788008882 MOSC domain; Region: MOSC; pfam03473 1225788008883 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1225788008884 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1225788008885 active site 1225788008886 NAD binding site [chemical binding]; other site 1225788008887 metal binding site [ion binding]; metal-binding site 1225788008888 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1225788008889 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1225788008890 tetramerization interface [polypeptide binding]; other site 1225788008891 NAD(P) binding site [chemical binding]; other site 1225788008892 catalytic residues [active] 1225788008893 Predicted transcriptional regulators [Transcription]; Region: COG1510 1225788008894 MarR family; Region: MarR_2; pfam12802 1225788008895 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1225788008896 TrkA-N domain; Region: TrkA_N; pfam02254 1225788008897 TrkA-C domain; Region: TrkA_C; pfam02080 1225788008898 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1225788008899 SH3-like domain; Region: SH3_8; pfam13457 1225788008900 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1225788008901 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1225788008902 heme-binding site [chemical binding]; other site 1225788008903 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1225788008904 FAD binding pocket [chemical binding]; other site 1225788008905 FAD binding motif [chemical binding]; other site 1225788008906 phosphate binding motif [ion binding]; other site 1225788008907 beta-alpha-beta structure motif; other site 1225788008908 NAD binding pocket [chemical binding]; other site 1225788008909 Heme binding pocket [chemical binding]; other site 1225788008910 Cupin; Region: Cupin_1; smart00835 1225788008911 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1225788008912 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1225788008913 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1225788008914 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1225788008915 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1225788008916 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1225788008917 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1225788008918 proposed catalytic triad [active] 1225788008919 conserved cys residue [active] 1225788008920 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1225788008921 Cache domain; Region: Cache_1; pfam02743 1225788008922 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1225788008923 dimerization interface [polypeptide binding]; other site 1225788008924 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1225788008925 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1225788008926 dimer interface [polypeptide binding]; other site 1225788008927 putative CheW interface [polypeptide binding]; other site 1225788008928 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1225788008929 Cache domain; Region: Cache_1; pfam02743 1225788008930 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1225788008931 dimerization interface [polypeptide binding]; other site 1225788008932 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1225788008933 dimer interface [polypeptide binding]; other site 1225788008934 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1225788008935 putative CheW interface [polypeptide binding]; other site 1225788008936 Tar ligand binding domain homologue; Region: TarH; pfam02203 1225788008937 Cache domain; Region: Cache_1; pfam02743 1225788008938 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1225788008939 dimerization interface [polypeptide binding]; other site 1225788008940 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1225788008941 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1225788008942 dimer interface [polypeptide binding]; other site 1225788008943 putative CheW interface [polypeptide binding]; other site 1225788008944 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1225788008945 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1225788008946 Cache domain; Region: Cache_1; pfam02743 1225788008947 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1225788008948 dimerization interface [polypeptide binding]; other site 1225788008949 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1225788008950 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1225788008951 dimer interface [polypeptide binding]; other site 1225788008952 putative CheW interface [polypeptide binding]; other site 1225788008953 transglutaminase; Provisional; Region: tgl; PRK03187 1225788008954 Nitronate monooxygenase; Region: NMO; pfam03060 1225788008955 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1225788008956 FMN binding site [chemical binding]; other site 1225788008957 substrate binding site [chemical binding]; other site 1225788008958 putative catalytic residue [active] 1225788008959 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1225788008960 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1225788008961 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1225788008962 Ca binding site [ion binding]; other site 1225788008963 active site 1225788008964 catalytic site [active] 1225788008965 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1225788008966 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1225788008967 Domain of unknown function DUF21; Region: DUF21; pfam01595 1225788008968 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1225788008969 Transporter associated domain; Region: CorC_HlyC; smart01091 1225788008970 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1225788008971 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1225788008972 Ion channel; Region: Ion_trans_2; pfam07885 1225788008973 TrkA-N domain; Region: TrkA_N; pfam02254 1225788008974 YugN-like family; Region: YugN; pfam08868 1225788008975 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1225788008976 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1225788008977 active site 1225788008978 dimer interface [polypeptide binding]; other site 1225788008979 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1225788008980 dimer interface [polypeptide binding]; other site 1225788008981 active site 1225788008982 Predicted flavoprotein [General function prediction only]; Region: COG0431 1225788008983 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1225788008984 Isochorismatase family; Region: Isochorismatase; pfam00857 1225788008985 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1225788008986 catalytic triad [active] 1225788008987 dimer interface [polypeptide binding]; other site 1225788008988 conserved cis-peptide bond; other site 1225788008989 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1225788008990 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1225788008991 dimer interface [polypeptide binding]; other site 1225788008992 active site 1225788008993 metal binding site [ion binding]; metal-binding site 1225788008994 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1225788008995 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1225788008996 dimer interface [polypeptide binding]; other site 1225788008997 active site 1225788008998 metal binding site [ion binding]; metal-binding site 1225788008999 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1225788009000 general stress protein 13; Validated; Region: PRK08059 1225788009001 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1225788009002 RNA binding site [nucleotide binding]; other site 1225788009003 hypothetical protein; Validated; Region: PRK07682 1225788009004 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1225788009005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788009006 homodimer interface [polypeptide binding]; other site 1225788009007 catalytic residue [active] 1225788009008 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1225788009009 AsnC family; Region: AsnC_trans_reg; pfam01037 1225788009010 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1225788009011 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1225788009012 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1225788009013 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1225788009014 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1225788009015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788009016 homodimer interface [polypeptide binding]; other site 1225788009017 catalytic residue [active] 1225788009018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1225788009019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788009020 dimer interface [polypeptide binding]; other site 1225788009021 phosphorylation site [posttranslational modification] 1225788009022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788009023 ATP binding site [chemical binding]; other site 1225788009024 Mg2+ binding site [ion binding]; other site 1225788009025 G-X-G motif; other site 1225788009026 Kinase associated protein B; Region: KapB; pfam08810 1225788009027 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1225788009028 active site 1225788009029 catalytic site [active] 1225788009030 substrate binding site [chemical binding]; other site 1225788009031 drug efflux system protein MdtG; Provisional; Region: PRK09874 1225788009032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788009033 putative substrate translocation pore; other site 1225788009034 Transglycosylase; Region: Transgly; pfam00912 1225788009035 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1225788009036 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1225788009037 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1225788009038 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1225788009039 PAS domain; Region: PAS; smart00091 1225788009040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788009041 ATP binding site [chemical binding]; other site 1225788009042 Mg2+ binding site [ion binding]; other site 1225788009043 G-X-G motif; other site 1225788009044 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1225788009045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788009046 active site 1225788009047 phosphorylation site [posttranslational modification] 1225788009048 intermolecular recognition site; other site 1225788009049 dimerization interface [polypeptide binding]; other site 1225788009050 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1225788009051 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1225788009052 ligand binding site [chemical binding]; other site 1225788009053 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1225788009054 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1225788009055 Walker A/P-loop; other site 1225788009056 ATP binding site [chemical binding]; other site 1225788009057 Q-loop/lid; other site 1225788009058 ABC transporter signature motif; other site 1225788009059 Walker B; other site 1225788009060 D-loop; other site 1225788009061 H-loop/switch region; other site 1225788009062 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1225788009063 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1225788009064 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1225788009065 TM-ABC transporter signature motif; other site 1225788009066 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1225788009067 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1225788009068 TM-ABC transporter signature motif; other site 1225788009069 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1225788009070 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1225788009071 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1225788009072 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1225788009073 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1225788009074 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1225788009075 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1225788009076 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1225788009077 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1225788009078 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1225788009079 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1225788009080 CoenzymeA binding site [chemical binding]; other site 1225788009081 subunit interaction site [polypeptide binding]; other site 1225788009082 PHB binding site; other site 1225788009083 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1225788009084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788009085 active site 1225788009086 phosphorylation site [posttranslational modification] 1225788009087 intermolecular recognition site; other site 1225788009088 dimerization interface [polypeptide binding]; other site 1225788009089 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1225788009090 DNA binding residues [nucleotide binding] 1225788009091 dimerization interface [polypeptide binding]; other site 1225788009092 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1225788009093 Histidine kinase; Region: HisKA_3; pfam07730 1225788009094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788009095 ATP binding site [chemical binding]; other site 1225788009096 Mg2+ binding site [ion binding]; other site 1225788009097 G-X-G motif; other site 1225788009098 Bacillus competence pheromone ComX; Region: ComX; pfam05952 1225788009099 Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867 1225788009100 substrate-Mg2+ binding site; other site 1225788009101 aspartate-rich region 2; other site 1225788009102 DegQ (SacQ) family; Region: DegQ; pfam08181 1225788009103 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1225788009104 EAL domain; Region: EAL; pfam00563 1225788009105 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1225788009106 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1225788009107 active site 1225788009108 Isochorismatase family; Region: Isochorismatase; pfam00857 1225788009109 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1225788009110 catalytic triad [active] 1225788009111 conserved cis-peptide bond; other site 1225788009112 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1225788009113 YueH-like protein; Region: YueH; pfam14166 1225788009114 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1225788009115 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1225788009116 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1225788009117 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1225788009118 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1225788009119 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1225788009120 Zn2+ binding site [ion binding]; other site 1225788009121 Mg2+ binding site [ion binding]; other site 1225788009122 short chain dehydrogenase; Provisional; Region: PRK06924 1225788009123 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1225788009124 NADP binding site [chemical binding]; other site 1225788009125 homodimer interface [polypeptide binding]; other site 1225788009126 active site 1225788009127 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1225788009128 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1225788009129 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1225788009130 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1225788009131 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1225788009132 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1225788009133 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1225788009134 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1225788009135 Domain of unknown function DUF87; Region: DUF87; pfam01935 1225788009136 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1225788009137 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 1225788009138 Uncharacterized small protein [Function unknown]; Region: COG5417 1225788009139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1225788009140 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1225788009141 CodY GAF-like domain; Region: CodY; pfam06018 1225788009142 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1225788009143 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1225788009144 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1225788009145 hexamer interface [polypeptide binding]; other site 1225788009146 ligand binding site [chemical binding]; other site 1225788009147 putative active site [active] 1225788009148 NAD(P) binding site [chemical binding]; other site 1225788009149 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1225788009150 MbtH-like protein; Region: MbtH; cl01279 1225788009151 Condensation domain; Region: Condensation; pfam00668 1225788009152 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1225788009153 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1225788009154 acyl-activating enzyme (AAE) consensus motif; other site 1225788009155 AMP binding site [chemical binding]; other site 1225788009156 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788009157 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1225788009158 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1225788009159 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1225788009160 acyl-activating enzyme (AAE) consensus motif; other site 1225788009161 AMP binding site [chemical binding]; other site 1225788009162 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1225788009163 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1225788009164 hydrophobic substrate binding pocket; other site 1225788009165 Isochorismatase family; Region: Isochorismatase; pfam00857 1225788009166 active site 1225788009167 conserved cis-peptide bond; other site 1225788009168 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1225788009169 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1225788009170 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1225788009171 acyl-activating enzyme (AAE) consensus motif; other site 1225788009172 active site 1225788009173 AMP binding site [chemical binding]; other site 1225788009174 substrate binding site [chemical binding]; other site 1225788009175 isochorismate synthase DhbC; Validated; Region: PRK06923 1225788009176 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1225788009177 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1225788009178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1225788009179 NAD(P) binding site [chemical binding]; other site 1225788009180 active site 1225788009181 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1225788009182 Putative esterase; Region: Esterase; pfam00756 1225788009183 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1225788009184 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1225788009185 Moco binding site; other site 1225788009186 metal coordination site [ion binding]; other site 1225788009187 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1225788009188 Predicted permease [General function prediction only]; Region: COG2056 1225788009189 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1225788009190 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1225788009191 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1225788009192 interface (dimer of trimers) [polypeptide binding]; other site 1225788009193 Substrate-binding/catalytic site; other site 1225788009194 Zn-binding sites [ion binding]; other site 1225788009195 Divergent PAP2 family; Region: DUF212; pfam02681 1225788009196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1225788009197 Putative membrane protein; Region: YuiB; pfam14068 1225788009198 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 1225788009199 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1225788009200 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1225788009201 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1225788009202 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1225788009203 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1225788009204 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1225788009205 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1225788009206 active site 1225788009207 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1225788009208 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1225788009209 Walker A/P-loop; other site 1225788009210 ATP binding site [chemical binding]; other site 1225788009211 Q-loop/lid; other site 1225788009212 ABC transporter signature motif; other site 1225788009213 Walker B; other site 1225788009214 D-loop; other site 1225788009215 H-loop/switch region; other site 1225788009216 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1225788009217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1225788009218 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1225788009219 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1225788009220 putative NAD(P) binding site [chemical binding]; other site 1225788009221 active site 1225788009222 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1225788009223 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1225788009224 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1225788009225 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1225788009226 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1225788009227 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1225788009228 Nucleoside recognition; Region: Gate; pfam07670 1225788009229 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1225788009230 hypothetical protein; Provisional; Region: PRK13669 1225788009231 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1225788009232 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1225788009233 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 1225788009234 NifU-like domain; Region: NifU; pfam01106 1225788009235 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1225788009236 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1225788009237 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1225788009238 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1225788009239 homoserine kinase; Provisional; Region: PRK01212 1225788009240 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1225788009241 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1225788009242 threonine synthase; Reviewed; Region: PRK06721 1225788009243 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1225788009244 homodimer interface [polypeptide binding]; other site 1225788009245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788009246 catalytic residue [active] 1225788009247 homoserine dehydrogenase; Provisional; Region: PRK06349 1225788009248 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1225788009249 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1225788009250 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1225788009251 spore coat protein YutH; Region: spore_yutH; TIGR02905 1225788009252 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1225788009253 tetramer interfaces [polypeptide binding]; other site 1225788009254 binuclear metal-binding site [ion binding]; other site 1225788009255 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1225788009256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788009257 active site 1225788009258 motif I; other site 1225788009259 motif II; other site 1225788009260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788009261 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1225788009262 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1225788009263 lipoyl synthase; Provisional; Region: PRK05481 1225788009264 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1225788009265 FeS/SAM binding site; other site 1225788009266 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1225788009267 Peptidase family M23; Region: Peptidase_M23; pfam01551 1225788009268 sporulation protein YunB; Region: spo_yunB; TIGR02832 1225788009269 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1225788009270 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1225788009271 active site 1225788009272 metal binding site [ion binding]; metal-binding site 1225788009273 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1225788009274 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1225788009275 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1225788009276 allantoinase; Provisional; Region: PRK06189 1225788009277 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1225788009278 active site 1225788009279 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1225788009280 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1225788009281 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1225788009282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1225788009283 binding surface 1225788009284 TPR motif; other site 1225788009285 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788009286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788009287 binding surface 1225788009288 TPR motif; other site 1225788009289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788009290 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788009291 putative substrate translocation pore; other site 1225788009292 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1225788009293 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1225788009294 catalytic residue [active] 1225788009295 allantoate amidohydrolase; Reviewed; Region: PRK09290 1225788009296 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1225788009297 active site 1225788009298 metal binding site [ion binding]; metal-binding site 1225788009299 dimer interface [polypeptide binding]; other site 1225788009300 Endonuclease I; Region: Endonuclease_1; cl01003 1225788009301 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1225788009302 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1225788009303 Walker A/P-loop; other site 1225788009304 ATP binding site [chemical binding]; other site 1225788009305 Q-loop/lid; other site 1225788009306 ABC transporter signature motif; other site 1225788009307 Walker B; other site 1225788009308 D-loop; other site 1225788009309 H-loop/switch region; other site 1225788009310 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1225788009311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788009312 DNA-binding site [nucleotide binding]; DNA binding site 1225788009313 UTRA domain; Region: UTRA; pfam07702 1225788009314 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1225788009315 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1225788009316 substrate binding site [chemical binding]; other site 1225788009317 ATP binding site [chemical binding]; other site 1225788009318 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1225788009319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788009320 dimer interface [polypeptide binding]; other site 1225788009321 conserved gate region; other site 1225788009322 putative PBP binding loops; other site 1225788009323 ABC-ATPase subunit interface; other site 1225788009324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788009325 dimer interface [polypeptide binding]; other site 1225788009326 conserved gate region; other site 1225788009327 putative PBP binding loops; other site 1225788009328 ABC-ATPase subunit interface; other site 1225788009329 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1225788009330 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1225788009331 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1225788009332 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1225788009333 putative active site [active] 1225788009334 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1225788009335 dimer interface [polypeptide binding]; other site 1225788009336 active site 1225788009337 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1225788009338 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1225788009339 DNA binding residues [nucleotide binding] 1225788009340 dimer interface [polypeptide binding]; other site 1225788009341 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 1225788009342 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1225788009343 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1225788009344 GIY-YIG motif/motif A; other site 1225788009345 active site 1225788009346 catalytic site [active] 1225788009347 putative DNA binding site [nucleotide binding]; other site 1225788009348 metal binding site [ion binding]; metal-binding site 1225788009349 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1225788009350 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1225788009351 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1225788009352 chitosan binding site [chemical binding]; other site 1225788009353 catalytic residues [active] 1225788009354 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1225788009355 FeS assembly protein SufB; Region: sufB; TIGR01980 1225788009356 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1225788009357 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1225788009358 trimerization site [polypeptide binding]; other site 1225788009359 active site 1225788009360 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1225788009361 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1225788009362 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1225788009363 catalytic residue [active] 1225788009364 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1225788009365 FeS assembly protein SufD; Region: sufD; TIGR01981 1225788009366 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1225788009367 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1225788009368 Walker A/P-loop; other site 1225788009369 ATP binding site [chemical binding]; other site 1225788009370 Q-loop/lid; other site 1225788009371 ABC transporter signature motif; other site 1225788009372 Walker B; other site 1225788009373 D-loop; other site 1225788009374 H-loop/switch region; other site 1225788009375 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1225788009376 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1225788009377 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1225788009378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788009379 dimer interface [polypeptide binding]; other site 1225788009380 conserved gate region; other site 1225788009381 ABC-ATPase subunit interface; other site 1225788009382 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1225788009383 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1225788009384 Walker A/P-loop; other site 1225788009385 ATP binding site [chemical binding]; other site 1225788009386 Q-loop/lid; other site 1225788009387 ABC transporter signature motif; other site 1225788009388 Walker B; other site 1225788009389 D-loop; other site 1225788009390 H-loop/switch region; other site 1225788009391 NIL domain; Region: NIL; pfam09383 1225788009392 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1225788009393 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1225788009394 catalytic residues [active] 1225788009395 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1225788009396 putative active site [active] 1225788009397 putative metal binding site [ion binding]; other site 1225788009398 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1225788009399 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1225788009400 lipoyl attachment site [posttranslational modification]; other site 1225788009401 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1225788009402 ArsC family; Region: ArsC; pfam03960 1225788009403 putative ArsC-like catalytic residues; other site 1225788009404 putative TRX-like catalytic residues [active] 1225788009405 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1225788009406 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1225788009407 active site 1225788009408 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1225788009409 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1225788009410 dimer interface [polypeptide binding]; other site 1225788009411 active site 1225788009412 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1225788009413 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1225788009414 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1225788009415 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1225788009416 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1225788009417 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1225788009418 substrate binding site [chemical binding]; other site 1225788009419 oxyanion hole (OAH) forming residues; other site 1225788009420 trimer interface [polypeptide binding]; other site 1225788009421 YuzL-like protein; Region: YuzL; pfam14115 1225788009422 Proline dehydrogenase; Region: Pro_dh; cl03282 1225788009423 Coat F domain; Region: Coat_F; pfam07875 1225788009424 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788009425 MarR family; Region: MarR; pfam01047 1225788009426 MarR family; Region: MarR_2; cl17246 1225788009427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788009428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788009429 putative substrate translocation pore; other site 1225788009430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788009431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788009432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788009433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1225788009434 dimerization interface [polypeptide binding]; other site 1225788009435 acetoacetate decarboxylase; Provisional; Region: PRK02265 1225788009436 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1225788009437 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1225788009438 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1225788009439 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1225788009440 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1225788009441 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1225788009442 Walker A/P-loop; other site 1225788009443 ATP binding site [chemical binding]; other site 1225788009444 Q-loop/lid; other site 1225788009445 ABC transporter signature motif; other site 1225788009446 Walker B; other site 1225788009447 D-loop; other site 1225788009448 H-loop/switch region; other site 1225788009449 YusW-like protein; Region: YusW; pfam14039 1225788009450 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1225788009451 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1225788009452 active site 1225788009453 Zn binding site [ion binding]; other site 1225788009454 short chain dehydrogenase; Provisional; Region: PRK06914 1225788009455 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1225788009456 NADP binding site [chemical binding]; other site 1225788009457 active site 1225788009458 steroid binding site; other site 1225788009459 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1225788009460 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1225788009461 dimerization interface [polypeptide binding]; other site 1225788009462 DPS ferroxidase diiron center [ion binding]; other site 1225788009463 ion pore; other site 1225788009464 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1225788009465 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1225788009466 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1225788009467 protein binding site [polypeptide binding]; other site 1225788009468 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1225788009469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788009470 active site 1225788009471 phosphorylation site [posttranslational modification] 1225788009472 intermolecular recognition site; other site 1225788009473 dimerization interface [polypeptide binding]; other site 1225788009474 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1225788009475 DNA binding site [nucleotide binding] 1225788009476 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1225788009477 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1225788009478 dimerization interface [polypeptide binding]; other site 1225788009479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788009480 dimer interface [polypeptide binding]; other site 1225788009481 phosphorylation site [posttranslational modification] 1225788009482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788009483 ATP binding site [chemical binding]; other site 1225788009484 Mg2+ binding site [ion binding]; other site 1225788009485 G-X-G motif; other site 1225788009486 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1225788009487 Class II fumarases; Region: Fumarase_classII; cd01362 1225788009488 active site 1225788009489 tetramer interface [polypeptide binding]; other site 1225788009490 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1225788009491 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1225788009492 Spore germination protein; Region: Spore_permease; pfam03845 1225788009493 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1225788009494 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1225788009495 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1225788009496 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1225788009497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788009498 active site 1225788009499 phosphorylation site [posttranslational modification] 1225788009500 intermolecular recognition site; other site 1225788009501 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1225788009502 DNA binding residues [nucleotide binding] 1225788009503 dimerization interface [polypeptide binding]; other site 1225788009504 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1225788009505 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1225788009506 dimerization interface [polypeptide binding]; other site 1225788009507 Histidine kinase; Region: HisKA_3; pfam07730 1225788009508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788009509 ATP binding site [chemical binding]; other site 1225788009510 Mg2+ binding site [ion binding]; other site 1225788009511 G-X-G motif; other site 1225788009512 Predicted membrane protein [Function unknown]; Region: COG4758 1225788009513 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1225788009514 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1225788009515 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1225788009516 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1225788009517 PspA/IM30 family; Region: PspA_IM30; pfam04012 1225788009518 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1225788009519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788009520 H+ Antiporter protein; Region: 2A0121; TIGR00900 1225788009521 putative substrate translocation pore; other site 1225788009522 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1225788009523 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1225788009524 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1225788009525 Walker A/P-loop; other site 1225788009526 ATP binding site [chemical binding]; other site 1225788009527 Q-loop/lid; other site 1225788009528 ABC transporter signature motif; other site 1225788009529 Walker B; other site 1225788009530 D-loop; other site 1225788009531 H-loop/switch region; other site 1225788009532 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 1225788009533 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1225788009534 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1225788009535 ABC-ATPase subunit interface; other site 1225788009536 dimer interface [polypeptide binding]; other site 1225788009537 putative PBP binding regions; other site 1225788009538 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1225788009539 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1225788009540 putative binding site residues; other site 1225788009541 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1225788009542 classical (c) SDRs; Region: SDR_c; cd05233 1225788009543 NAD(P) binding site [chemical binding]; other site 1225788009544 active site 1225788009545 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1225788009546 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1225788009547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788009548 dimer interface [polypeptide binding]; other site 1225788009549 phosphorylation site [posttranslational modification] 1225788009550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788009551 ATP binding site [chemical binding]; other site 1225788009552 Mg2+ binding site [ion binding]; other site 1225788009553 G-X-G motif; other site 1225788009554 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1225788009555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788009556 active site 1225788009557 phosphorylation site [posttranslational modification] 1225788009558 intermolecular recognition site; other site 1225788009559 dimerization interface [polypeptide binding]; other site 1225788009560 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1225788009561 DNA binding site [nucleotide binding] 1225788009562 hypothetical protein; Provisional; Region: PRK14082 1225788009563 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1225788009564 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1225788009565 DNA binding residues [nucleotide binding] 1225788009566 YvrJ protein family; Region: YvrJ; pfam12841 1225788009567 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1225788009568 Cupin; Region: Cupin_1; smart00835 1225788009569 Cupin; Region: Cupin_1; smart00835 1225788009570 Regulatory protein YrvL; Region: YrvL; pfam14184 1225788009571 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1225788009572 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1225788009573 Walker A/P-loop; other site 1225788009574 ATP binding site [chemical binding]; other site 1225788009575 Q-loop/lid; other site 1225788009576 ABC transporter signature motif; other site 1225788009577 Walker B; other site 1225788009578 D-loop; other site 1225788009579 H-loop/switch region; other site 1225788009580 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1225788009581 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1225788009582 ABC-ATPase subunit interface; other site 1225788009583 dimer interface [polypeptide binding]; other site 1225788009584 putative PBP binding regions; other site 1225788009585 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1225788009586 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1225788009587 ABC-ATPase subunit interface; other site 1225788009588 dimer interface [polypeptide binding]; other site 1225788009589 putative PBP binding regions; other site 1225788009590 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1225788009591 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1225788009592 putative ligand binding residues [chemical binding]; other site 1225788009593 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 1225788009594 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; cl09798 1225788009595 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1225788009596 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1225788009597 Sulfatase; Region: Sulfatase; pfam00884 1225788009598 DNA binding domain, excisionase family; Region: excise; TIGR01764 1225788009599 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 1225788009600 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1225788009601 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1225788009602 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1225788009603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788009604 dimer interface [polypeptide binding]; other site 1225788009605 conserved gate region; other site 1225788009606 putative PBP binding loops; other site 1225788009607 ABC-ATPase subunit interface; other site 1225788009608 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1225788009609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788009610 active site 1225788009611 phosphorylation site [posttranslational modification] 1225788009612 intermolecular recognition site; other site 1225788009613 dimerization interface [polypeptide binding]; other site 1225788009614 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1225788009615 DNA binding residues [nucleotide binding] 1225788009616 dimerization interface [polypeptide binding]; other site 1225788009617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1225788009618 Histidine kinase; Region: HisKA_3; pfam07730 1225788009619 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1225788009620 ATP binding site [chemical binding]; other site 1225788009621 Mg2+ binding site [ion binding]; other site 1225788009622 G-X-G motif; other site 1225788009623 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1225788009624 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1225788009625 Walker A/P-loop; other site 1225788009626 ATP binding site [chemical binding]; other site 1225788009627 Q-loop/lid; other site 1225788009628 ABC transporter signature motif; other site 1225788009629 Walker B; other site 1225788009630 D-loop; other site 1225788009631 H-loop/switch region; other site 1225788009632 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1225788009633 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1225788009634 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1225788009635 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1225788009636 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1225788009637 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1225788009638 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1225788009639 active site 1225788009640 catalytic tetrad [active] 1225788009641 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1225788009642 sulfite reductase subunit beta; Provisional; Region: PRK13504 1225788009643 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1225788009644 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1225788009645 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1225788009646 Flavodoxin; Region: Flavodoxin_1; pfam00258 1225788009647 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1225788009648 FAD binding pocket [chemical binding]; other site 1225788009649 FAD binding motif [chemical binding]; other site 1225788009650 catalytic residues [active] 1225788009651 NAD binding pocket [chemical binding]; other site 1225788009652 phosphate binding motif [ion binding]; other site 1225788009653 beta-alpha-beta structure motif; other site 1225788009654 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1225788009655 Family description; Region: UvrD_C_2; pfam13538 1225788009656 Predicted membrane protein [Function unknown]; Region: COG2860 1225788009657 UPF0126 domain; Region: UPF0126; pfam03458 1225788009658 UPF0126 domain; Region: UPF0126; pfam03458 1225788009659 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 1225788009660 active site 1225788009661 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1225788009662 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1225788009663 Thioredoxin; Region: Thioredoxin_4; pfam13462 1225788009664 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1225788009665 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1225788009666 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1225788009667 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1225788009668 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1225788009669 metal-binding site [ion binding] 1225788009670 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1225788009671 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1225788009672 metal-binding site [ion binding] 1225788009673 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1225788009674 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1225788009675 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1225788009676 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1225788009677 metal-binding site [ion binding] 1225788009678 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1225788009679 putative homodimer interface [polypeptide binding]; other site 1225788009680 putative homotetramer interface [polypeptide binding]; other site 1225788009681 putative allosteric switch controlling residues; other site 1225788009682 putative metal binding site [ion binding]; other site 1225788009683 putative homodimer-homodimer interface [polypeptide binding]; other site 1225788009684 putative oxidoreductase; Provisional; Region: PRK11579 1225788009685 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1225788009686 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1225788009687 azoreductase; Reviewed; Region: PRK00170 1225788009688 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1225788009689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788009690 salt bridge; other site 1225788009691 non-specific DNA binding site [nucleotide binding]; other site 1225788009692 sequence-specific DNA binding site [nucleotide binding]; other site 1225788009693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788009694 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788009695 putative substrate translocation pore; other site 1225788009696 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1225788009697 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1225788009698 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1225788009699 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1225788009700 active site 1225788009701 non-prolyl cis peptide bond; other site 1225788009702 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1225788009703 catalytic residues [active] 1225788009704 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1225788009705 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1225788009706 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1225788009707 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1225788009708 Walker A/P-loop; other site 1225788009709 ATP binding site [chemical binding]; other site 1225788009710 Q-loop/lid; other site 1225788009711 ABC transporter signature motif; other site 1225788009712 Walker B; other site 1225788009713 D-loop; other site 1225788009714 H-loop/switch region; other site 1225788009715 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1225788009716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788009717 dimer interface [polypeptide binding]; other site 1225788009718 conserved gate region; other site 1225788009719 putative PBP binding loops; other site 1225788009720 ABC-ATPase subunit interface; other site 1225788009721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788009722 dimer interface [polypeptide binding]; other site 1225788009723 conserved gate region; other site 1225788009724 putative PBP binding loops; other site 1225788009725 ABC-ATPase subunit interface; other site 1225788009726 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1225788009727 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1225788009728 substrate binding pocket [chemical binding]; other site 1225788009729 membrane-bound complex binding site; other site 1225788009730 hinge residues; other site 1225788009731 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1225788009732 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1225788009733 substrate binding pocket [chemical binding]; other site 1225788009734 membrane-bound complex binding site; other site 1225788009735 hinge residues; other site 1225788009736 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1225788009737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788009738 Coenzyme A binding pocket [chemical binding]; other site 1225788009739 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1225788009740 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788009741 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788009742 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1225788009743 dimerization interface [polypeptide binding]; other site 1225788009744 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1225788009745 classical (c) SDRs; Region: SDR_c; cd05233 1225788009746 NAD(P) binding site [chemical binding]; other site 1225788009747 active site 1225788009748 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1225788009749 RNAase interaction site [polypeptide binding]; other site 1225788009750 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1225788009751 SmpB-tmRNA interface; other site 1225788009752 putative transporter; Provisional; Region: PRK03699 1225788009753 ribonuclease R; Region: RNase_R; TIGR02063 1225788009754 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1225788009755 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1225788009756 RNB domain; Region: RNB; pfam00773 1225788009757 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1225788009758 RNA binding site [nucleotide binding]; other site 1225788009759 Esterase/lipase [General function prediction only]; Region: COG1647 1225788009760 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1225788009761 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1225788009762 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788009763 salt bridge; other site 1225788009764 non-specific DNA binding site [nucleotide binding]; other site 1225788009765 sequence-specific DNA binding site [nucleotide binding]; other site 1225788009766 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1225788009767 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788009768 non-specific DNA binding site [nucleotide binding]; other site 1225788009769 salt bridge; other site 1225788009770 sequence-specific DNA binding site [nucleotide binding]; other site 1225788009771 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1225788009772 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788009773 non-specific DNA binding site [nucleotide binding]; other site 1225788009774 salt bridge; other site 1225788009775 sequence-specific DNA binding site [nucleotide binding]; other site 1225788009776 Predicted transcriptional regulators [Transcription]; Region: COG1733 1225788009777 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1225788009778 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1225788009779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788009780 dimer interface [polypeptide binding]; other site 1225788009781 phosphorylation site [posttranslational modification] 1225788009782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788009783 ATP binding site [chemical binding]; other site 1225788009784 Mg2+ binding site [ion binding]; other site 1225788009785 G-X-G motif; other site 1225788009786 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1225788009787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788009788 active site 1225788009789 phosphorylation site [posttranslational modification] 1225788009790 intermolecular recognition site; other site 1225788009791 dimerization interface [polypeptide binding]; other site 1225788009792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1225788009793 DNA binding site [nucleotide binding] 1225788009794 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1225788009795 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1225788009796 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1225788009797 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1225788009798 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1225788009799 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1225788009800 Walker A/P-loop; other site 1225788009801 ATP binding site [chemical binding]; other site 1225788009802 Q-loop/lid; other site 1225788009803 ABC transporter signature motif; other site 1225788009804 Walker B; other site 1225788009805 D-loop; other site 1225788009806 H-loop/switch region; other site 1225788009807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788009808 dimer interface [polypeptide binding]; other site 1225788009809 conserved gate region; other site 1225788009810 putative PBP binding loops; other site 1225788009811 ABC-ATPase subunit interface; other site 1225788009812 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1225788009813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788009814 dimer interface [polypeptide binding]; other site 1225788009815 conserved gate region; other site 1225788009816 putative PBP binding loops; other site 1225788009817 ABC-ATPase subunit interface; other site 1225788009818 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1225788009819 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1225788009820 Walker A/P-loop; other site 1225788009821 ATP binding site [chemical binding]; other site 1225788009822 Q-loop/lid; other site 1225788009823 ABC transporter signature motif; other site 1225788009824 Walker B; other site 1225788009825 D-loop; other site 1225788009826 H-loop/switch region; other site 1225788009827 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1225788009828 Predicted transcriptional regulators [Transcription]; Region: COG1510 1225788009829 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1225788009830 putative DNA binding site [nucleotide binding]; other site 1225788009831 putative Zn2+ binding site [ion binding]; other site 1225788009832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788009833 dimer interface [polypeptide binding]; other site 1225788009834 conserved gate region; other site 1225788009835 putative PBP binding loops; other site 1225788009836 ABC-ATPase subunit interface; other site 1225788009837 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1225788009838 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1225788009839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1225788009840 dimer interface [polypeptide binding]; other site 1225788009841 conserved gate region; other site 1225788009842 putative PBP binding loops; other site 1225788009843 ABC-ATPase subunit interface; other site 1225788009844 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1225788009845 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1225788009846 Walker A/P-loop; other site 1225788009847 ATP binding site [chemical binding]; other site 1225788009848 Q-loop/lid; other site 1225788009849 ABC transporter signature motif; other site 1225788009850 Walker B; other site 1225788009851 D-loop; other site 1225788009852 H-loop/switch region; other site 1225788009853 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1225788009854 Predicted transcriptional regulators [Transcription]; Region: COG1510 1225788009855 MarR family; Region: MarR_2; pfam12802 1225788009856 membrane protein, MarC family; Region: TIGR00427 1225788009857 Predicted membrane protein [Function unknown]; Region: COG4640 1225788009858 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1225788009859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788009860 Coenzyme A binding pocket [chemical binding]; other site 1225788009861 H+ Antiporter protein; Region: 2A0121; TIGR00900 1225788009862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788009863 putative substrate translocation pore; other site 1225788009864 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1225788009865 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1225788009866 WbqC-like protein family; Region: WbqC; pfam08889 1225788009867 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1225788009868 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1225788009869 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1225788009870 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1225788009871 catalytic residue [active] 1225788009872 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1225788009873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1225788009874 NAD(P) binding site [chemical binding]; other site 1225788009875 active site 1225788009876 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1225788009877 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1225788009878 inhibitor-cofactor binding pocket; inhibition site 1225788009879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788009880 catalytic residue [active] 1225788009881 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1225788009882 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1225788009883 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1225788009884 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1225788009885 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1225788009886 putative integrin binding motif; other site 1225788009887 PA/protease domain interface [polypeptide binding]; other site 1225788009888 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1225788009889 Peptidase family M28; Region: Peptidase_M28; pfam04389 1225788009890 metal binding site [ion binding]; metal-binding site 1225788009891 enolase; Provisional; Region: eno; PRK00077 1225788009892 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1225788009893 dimer interface [polypeptide binding]; other site 1225788009894 metal binding site [ion binding]; metal-binding site 1225788009895 substrate binding pocket [chemical binding]; other site 1225788009896 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1225788009897 phosphoglyceromutase; Provisional; Region: PRK05434 1225788009898 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1225788009899 triosephosphate isomerase; Provisional; Region: PRK14565 1225788009900 substrate binding site [chemical binding]; other site 1225788009901 dimer interface [polypeptide binding]; other site 1225788009902 catalytic triad [active] 1225788009903 Phosphoglycerate kinase; Region: PGK; pfam00162 1225788009904 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1225788009905 substrate binding site [chemical binding]; other site 1225788009906 hinge regions; other site 1225788009907 ADP binding site [chemical binding]; other site 1225788009908 catalytic site [active] 1225788009909 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1225788009910 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1225788009911 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1225788009912 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1225788009913 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1225788009914 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1225788009915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788009916 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788009917 DNA-binding site [nucleotide binding]; DNA binding site 1225788009918 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1225788009919 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1225788009920 putative dimerization interface [polypeptide binding]; other site 1225788009921 putative ligand binding site [chemical binding]; other site 1225788009922 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1225788009923 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1225788009924 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1225788009925 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788009926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788009927 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1225788009928 dimerization interface [polypeptide binding]; other site 1225788009929 EamA-like transporter family; Region: EamA; pfam00892 1225788009930 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1225788009931 EamA-like transporter family; Region: EamA; pfam00892 1225788009932 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1225788009933 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1225788009934 active site 1225788009935 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1225788009936 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1225788009937 DNA binding site [nucleotide binding] 1225788009938 domain linker motif; other site 1225788009939 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1225788009940 putative ligand binding site [chemical binding]; other site 1225788009941 putative dimerization interface [polypeptide binding]; other site 1225788009942 Predicted membrane protein [Function unknown]; Region: COG2364 1225788009943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788009944 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1225788009945 active site 1225788009946 motif I; other site 1225788009947 motif II; other site 1225788009948 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788009949 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1225788009950 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1225788009951 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1225788009952 putative active site [active] 1225788009953 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1225788009954 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1225788009955 N- and C-terminal domain interface [polypeptide binding]; other site 1225788009956 active site 1225788009957 catalytic site [active] 1225788009958 metal binding site [ion binding]; metal-binding site 1225788009959 carbohydrate binding site [chemical binding]; other site 1225788009960 ATP binding site [chemical binding]; other site 1225788009961 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1225788009962 GntP family permease; Region: GntP_permease; pfam02447 1225788009963 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1225788009964 iron-sulfur cluster-binding protein; Region: TIGR00273 1225788009965 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1225788009966 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1225788009967 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1225788009968 Cysteine-rich domain; Region: CCG; pfam02754 1225788009969 Cysteine-rich domain; Region: CCG; pfam02754 1225788009970 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1225788009971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1225788009972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788009973 homodimer interface [polypeptide binding]; other site 1225788009974 catalytic residue [active] 1225788009975 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1225788009976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788009977 DNA-binding site [nucleotide binding]; DNA binding site 1225788009978 FCD domain; Region: FCD; pfam07729 1225788009979 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1225788009980 L-lactate permease; Region: Lactate_perm; pfam02652 1225788009981 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1225788009982 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1225788009983 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1225788009984 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1225788009985 YvfG protein; Region: YvfG; pfam09628 1225788009986 potential frameshift: common BLAST hit: gi|375363870|ref|YP_005131909.1| putative pyruvyl transferase epsO 1225788009987 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1225788009988 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1225788009989 inhibitor-cofactor binding pocket; inhibition site 1225788009990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788009991 catalytic residue [active] 1225788009992 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1225788009993 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1225788009994 putative trimer interface [polypeptide binding]; other site 1225788009995 putative CoA binding site [chemical binding]; other site 1225788009996 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1225788009997 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1225788009998 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1225788009999 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1225788010000 active site 1225788010001 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1225788010002 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1225788010003 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1225788010004 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1225788010005 active site 1225788010006 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1225788010007 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1225788010008 putative ADP-binding pocket [chemical binding]; other site 1225788010009 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1225788010010 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1225788010011 active site 1225788010012 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1225788010013 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1225788010014 putative ADP-binding pocket [chemical binding]; other site 1225788010015 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1225788010016 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1225788010017 NAD(P) binding site [chemical binding]; other site 1225788010018 homodimer interface [polypeptide binding]; other site 1225788010019 substrate binding site [chemical binding]; other site 1225788010020 active site 1225788010021 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1225788010022 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1225788010023 potential frameshift: common BLAST hit: gi|387900056|ref|YP_006330352.1| protein-tyrosine kinase 1225788010024 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1225788010025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788010026 non-specific DNA binding site [nucleotide binding]; other site 1225788010027 salt bridge; other site 1225788010028 sequence-specific DNA binding site [nucleotide binding]; other site 1225788010029 Anti-repressor SinI; Region: SinI; pfam08671 1225788010030 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1225788010031 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1225788010032 substrate binding pocket [chemical binding]; other site 1225788010033 catalytic triad [active] 1225788010034 RibD C-terminal domain; Region: RibD_C; cl17279 1225788010035 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1225788010036 Predicted membrane protein [Function unknown]; Region: COG2364 1225788010037 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1225788010038 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1225788010039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788010040 Coenzyme A binding pocket [chemical binding]; other site 1225788010041 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1225788010042 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 1225788010043 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1225788010044 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1225788010045 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1225788010046 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1225788010047 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1225788010048 active site 1225788010049 Int/Topo IB signature motif; other site 1225788010050 DNA binding site [nucleotide binding] 1225788010051 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1225788010052 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1225788010053 substrate binding [chemical binding]; other site 1225788010054 active site 1225788010055 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1225788010056 galactoside permease; Reviewed; Region: lacY; PRK09528 1225788010057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788010058 putative substrate translocation pore; other site 1225788010059 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1225788010060 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1225788010061 DNA binding site [nucleotide binding] 1225788010062 domain linker motif; other site 1225788010063 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1225788010064 dimerization interface [polypeptide binding]; other site 1225788010065 ligand binding site [chemical binding]; other site 1225788010066 sodium binding site [ion binding]; other site 1225788010067 Clp protease; Region: CLP_protease; pfam00574 1225788010068 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1225788010069 oligomer interface [polypeptide binding]; other site 1225788010070 active site residues [active] 1225788010071 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788010072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788010073 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1225788010074 dimerization interface [polypeptide binding]; other site 1225788010075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1225788010076 benzoate transport; Region: 2A0115; TIGR00895 1225788010077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788010078 putative substrate translocation pore; other site 1225788010079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788010080 TIGR00730 family protein; Region: TIGR00730 1225788010081 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1225788010082 metal binding site [ion binding]; metal-binding site 1225788010083 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1225788010084 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1225788010085 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1225788010086 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1225788010087 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1225788010088 active site clefts [active] 1225788010089 zinc binding site [ion binding]; other site 1225788010090 dimer interface [polypeptide binding]; other site 1225788010091 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1225788010092 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1225788010093 dimerization interface [polypeptide binding]; other site 1225788010094 ligand binding site [chemical binding]; other site 1225788010095 NADP binding site [chemical binding]; other site 1225788010096 catalytic site [active] 1225788010097 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 1225788010098 active site 1225788010099 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1225788010100 Alpha-kinase family; Region: Alpha_kinase; cl03728 1225788010101 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1225788010102 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1225788010103 dimerization domain swap beta strand [polypeptide binding]; other site 1225788010104 regulatory protein interface [polypeptide binding]; other site 1225788010105 active site 1225788010106 regulatory phosphorylation site [posttranslational modification]; other site 1225788010107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1225788010108 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1225788010109 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1225788010110 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1225788010111 phosphate binding site [ion binding]; other site 1225788010112 putative substrate binding pocket [chemical binding]; other site 1225788010113 dimer interface [polypeptide binding]; other site 1225788010114 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1225788010115 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1225788010116 putative active site [active] 1225788010117 nucleotide binding site [chemical binding]; other site 1225788010118 nudix motif; other site 1225788010119 putative metal binding site [ion binding]; other site 1225788010120 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1225788010121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1225788010122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1225788010123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1225788010124 GDP/GTP exchange factor Sec2p; Region: Sec2p; pfam06428 1225788010125 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1225788010126 NlpC/P60 family; Region: NLPC_P60; pfam00877 1225788010127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788010128 binding surface 1225788010129 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1225788010130 TPR motif; other site 1225788010131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788010132 TPR motif; other site 1225788010133 binding surface 1225788010134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1225788010135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788010136 dimer interface [polypeptide binding]; other site 1225788010137 phosphorylation site [posttranslational modification] 1225788010138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788010139 ATP binding site [chemical binding]; other site 1225788010140 Mg2+ binding site [ion binding]; other site 1225788010141 G-X-G motif; other site 1225788010142 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1225788010143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788010144 active site 1225788010145 phosphorylation site [posttranslational modification] 1225788010146 intermolecular recognition site; other site 1225788010147 dimerization interface [polypeptide binding]; other site 1225788010148 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1225788010149 DNA binding site [nucleotide binding] 1225788010150 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1225788010151 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1225788010152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1225788010153 Walker A/P-loop; other site 1225788010154 ATP binding site [chemical binding]; other site 1225788010155 Q-loop/lid; other site 1225788010156 ABC transporter signature motif; other site 1225788010157 Walker B; other site 1225788010158 D-loop; other site 1225788010159 H-loop/switch region; other site 1225788010160 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1225788010161 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1225788010162 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1225788010163 metal binding site [ion binding]; metal-binding site 1225788010164 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1225788010165 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1225788010166 substrate binding site [chemical binding]; other site 1225788010167 glutamase interaction surface [polypeptide binding]; other site 1225788010168 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1225788010169 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1225788010170 catalytic residues [active] 1225788010171 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1225788010172 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1225788010173 putative active site [active] 1225788010174 oxyanion strand; other site 1225788010175 catalytic triad [active] 1225788010176 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1225788010177 putative active site pocket [active] 1225788010178 4-fold oligomerization interface [polypeptide binding]; other site 1225788010179 metal binding residues [ion binding]; metal-binding site 1225788010180 3-fold/trimer interface [polypeptide binding]; other site 1225788010181 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1225788010182 histidinol dehydrogenase; Region: hisD; TIGR00069 1225788010183 NAD binding site [chemical binding]; other site 1225788010184 dimerization interface [polypeptide binding]; other site 1225788010185 product binding site; other site 1225788010186 substrate binding site [chemical binding]; other site 1225788010187 zinc binding site [ion binding]; other site 1225788010188 catalytic residues [active] 1225788010189 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1225788010190 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1225788010191 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1225788010192 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1225788010193 dimer interface [polypeptide binding]; other site 1225788010194 motif 1; other site 1225788010195 active site 1225788010196 motif 2; other site 1225788010197 motif 3; other site 1225788010198 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1225788010199 putative active site [active] 1225788010200 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1225788010201 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1225788010202 trimer interface [polypeptide binding]; other site 1225788010203 active site 1225788010204 substrate binding site [chemical binding]; other site 1225788010205 CoA binding site [chemical binding]; other site 1225788010206 pyrophosphatase PpaX; Provisional; Region: PRK13288 1225788010207 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1225788010208 motif I; other site 1225788010209 active site 1225788010210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788010211 motif II; other site 1225788010212 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1225788010213 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1225788010214 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1225788010215 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1225788010216 Hpr binding site; other site 1225788010217 active site 1225788010218 homohexamer subunit interaction site [polypeptide binding]; other site 1225788010219 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1225788010220 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1225788010221 active site 1225788010222 dimer interface [polypeptide binding]; other site 1225788010223 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1225788010224 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1225788010225 active site 1225788010226 trimer interface [polypeptide binding]; other site 1225788010227 allosteric site; other site 1225788010228 active site lid [active] 1225788010229 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1225788010230 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1225788010231 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788010232 DNA-binding site [nucleotide binding]; DNA binding site 1225788010233 UTRA domain; Region: UTRA; pfam07702 1225788010234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788010235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788010236 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1225788010237 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1225788010238 putative active site [active] 1225788010239 putative metal binding site [ion binding]; other site 1225788010240 Predicted membrane protein [Function unknown]; Region: COG1950 1225788010241 PspC domain; Region: PspC; pfam04024 1225788010242 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1225788010243 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1225788010244 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1225788010245 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1225788010246 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1225788010247 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1225788010248 excinuclease ABC subunit B; Provisional; Region: PRK05298 1225788010249 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1225788010250 ATP binding site [chemical binding]; other site 1225788010251 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1225788010252 nucleotide binding region [chemical binding]; other site 1225788010253 ATP-binding site [chemical binding]; other site 1225788010254 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1225788010255 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 1225788010256 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1225788010257 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1225788010258 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1225788010259 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788010260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788010261 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1225788010262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788010263 putative substrate translocation pore; other site 1225788010264 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1225788010265 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1225788010266 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1225788010267 C-terminal peptidase (prc); Region: prc; TIGR00225 1225788010268 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1225788010269 protein binding site [polypeptide binding]; other site 1225788010270 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1225788010271 Catalytic dyad [active] 1225788010272 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1225788010273 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1225788010274 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1225788010275 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1225788010276 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1225788010277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1225788010278 Walker A/P-loop; other site 1225788010279 ATP binding site [chemical binding]; other site 1225788010280 Q-loop/lid; other site 1225788010281 ABC transporter signature motif; other site 1225788010282 Walker B; other site 1225788010283 D-loop; other site 1225788010284 H-loop/switch region; other site 1225788010285 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1225788010286 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1225788010287 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1225788010288 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1225788010289 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1225788010290 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1225788010291 peptide chain release factor 2; Provisional; Region: PRK06746 1225788010292 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1225788010293 RF-1 domain; Region: RF-1; pfam00472 1225788010294 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1225788010295 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1225788010296 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1225788010297 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1225788010298 nucleotide binding region [chemical binding]; other site 1225788010299 ATP-binding site [chemical binding]; other site 1225788010300 SEC-C motif; Region: SEC-C; pfam02810 1225788010301 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1225788010302 30S subunit binding site; other site 1225788010303 Flagellar protein FliT; Region: FliT; pfam05400 1225788010304 flagellar protein FliS; Validated; Region: fliS; PRK05685 1225788010305 flagellar capping protein; Validated; Region: fliD; PRK07737 1225788010306 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1225788010307 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1225788010308 flagellin; Provisional; Region: PRK12804 1225788010309 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1225788010310 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1225788010311 carbon storage regulator; Provisional; Region: PRK01712 1225788010312 flagellar assembly protein FliW; Provisional; Region: PRK13285 1225788010313 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1225788010314 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1225788010315 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1225788010316 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1225788010317 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1225788010318 FlgN protein; Region: FlgN; pfam05130 1225788010319 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1225788010320 flagellar operon protein TIGR03826; Region: YvyF 1225788010321 comF family protein; Region: comF; TIGR00201 1225788010322 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1225788010323 active site 1225788010324 Late competence development protein ComFB; Region: ComFB; pfam10719 1225788010325 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1225788010326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1225788010327 ATP binding site [chemical binding]; other site 1225788010328 putative Mg++ binding site [ion binding]; other site 1225788010329 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1225788010330 nucleotide binding region [chemical binding]; other site 1225788010331 ATP-binding site [chemical binding]; other site 1225788010332 EDD domain protein, DegV family; Region: DegV; TIGR00762 1225788010333 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1225788010334 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1225788010335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788010336 active site 1225788010337 phosphorylation site [posttranslational modification] 1225788010338 intermolecular recognition site; other site 1225788010339 dimerization interface [polypeptide binding]; other site 1225788010340 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1225788010341 DNA binding residues [nucleotide binding] 1225788010342 dimerization interface [polypeptide binding]; other site 1225788010343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1225788010344 Histidine kinase; Region: HisKA_3; pfam07730 1225788010345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788010346 ATP binding site [chemical binding]; other site 1225788010347 Mg2+ binding site [ion binding]; other site 1225788010348 G-X-G motif; other site 1225788010349 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1225788010350 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1225788010351 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1225788010352 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1225788010353 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1225788010354 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1225788010355 Mg++ binding site [ion binding]; other site 1225788010356 putative catalytic motif [active] 1225788010357 substrate binding site [chemical binding]; other site 1225788010358 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1225788010359 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1225788010360 putative homodimer interface [polypeptide binding]; other site 1225788010361 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1225788010362 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1225788010363 active site 1225788010364 O-Antigen ligase; Region: Wzy_C; pfam04932 1225788010365 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1225788010366 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1225788010367 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1225788010368 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1225788010369 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1225788010370 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1225788010371 colanic acid exporter; Provisional; Region: PRK10459 1225788010372 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1225788010373 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1225788010374 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1225788010375 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1225788010376 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1225788010377 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1225788010378 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1225788010379 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1225788010380 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1225788010381 active site 1225788010382 metal binding site [ion binding]; metal-binding site 1225788010383 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1225788010384 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1225788010385 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1225788010386 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1225788010387 Stage II sporulation protein; Region: SpoIID; pfam08486 1225788010388 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1225788010389 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 1225788010390 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1225788010391 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1225788010392 active site 1225788010393 homodimer interface [polypeptide binding]; other site 1225788010394 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1225788010395 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1225788010396 active site 1225788010397 tetramer interface; other site 1225788010398 potential frameshift: common BLAST hit: gi|384170275|ref|YP_005551653.1| ATP-binding teichoic acid precursor transporter 1225788010399 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1225788010400 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1225788010401 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1225788010402 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1225788010403 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1225788010404 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1225788010405 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1225788010406 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1225788010407 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1225788010408 active site 1225788010409 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1225788010410 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1225788010411 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1225788010412 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1225788010413 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1225788010414 Bacterial SH3 domain; Region: SH3_3; pfam08239 1225788010415 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1225788010416 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1225788010417 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1225788010418 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1225788010419 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1225788010420 Spore germination protein; Region: Spore_permease; pfam03845 1225788010421 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1225788010422 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1225788010423 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1225788010424 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1225788010425 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1225788010426 Probable Catalytic site; other site 1225788010427 metal-binding site 1225788010428 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1225788010429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788010430 S-adenosylmethionine binding site [chemical binding]; other site 1225788010431 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1225788010432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788010433 putative substrate translocation pore; other site 1225788010434 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1225788010435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788010436 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1225788010437 active site 1225788010438 motif I; other site 1225788010439 motif II; other site 1225788010440 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1225788010441 Septum formation initiator; Region: DivIC; cl17659 1225788010442 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 1225788010443 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1225788010444 NlpC/P60 family; Region: NLPC_P60; pfam00877 1225788010445 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1225788010446 NlpC/P60 family; Region: NLPC_P60; pfam00877 1225788010447 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1225788010448 NlpC/P60 family; Region: NLPC_P60; pfam00877 1225788010449 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1225788010450 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1225788010451 putative active site [active] 1225788010452 putative metal binding site [ion binding]; other site 1225788010453 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 1225788010454 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1225788010455 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1225788010456 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1225788010457 Spore germination protein; Region: Spore_permease; cl17796 1225788010458 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1225788010459 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1225788010460 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1225788010461 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1225788010462 DNA binding site [nucleotide binding] 1225788010463 domain linker motif; other site 1225788010464 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1225788010465 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1225788010466 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1225788010467 substrate binding site [chemical binding]; other site 1225788010468 dimer interface [polypeptide binding]; other site 1225788010469 ATP binding site [chemical binding]; other site 1225788010470 D-ribose pyranase; Provisional; Region: PRK11797 1225788010471 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1225788010472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1225788010473 Walker A/P-loop; other site 1225788010474 ATP binding site [chemical binding]; other site 1225788010475 Q-loop/lid; other site 1225788010476 ABC transporter signature motif; other site 1225788010477 Walker B; other site 1225788010478 D-loop; other site 1225788010479 H-loop/switch region; other site 1225788010480 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1225788010481 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1225788010482 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1225788010483 TM-ABC transporter signature motif; other site 1225788010484 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1225788010485 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1225788010486 ligand binding site [chemical binding]; other site 1225788010487 dimerization interface [polypeptide binding]; other site 1225788010488 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1225788010489 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1225788010490 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1225788010491 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1225788010492 acetolactate synthase; Reviewed; Region: PRK08617 1225788010493 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1225788010494 PYR/PP interface [polypeptide binding]; other site 1225788010495 dimer interface [polypeptide binding]; other site 1225788010496 TPP binding site [chemical binding]; other site 1225788010497 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1225788010498 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1225788010499 TPP-binding site [chemical binding]; other site 1225788010500 dimer interface [polypeptide binding]; other site 1225788010501 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1225788010502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788010503 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1225788010504 putative dimerization interface [polypeptide binding]; other site 1225788010505 putative substrate binding pocket [chemical binding]; other site 1225788010506 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1225788010507 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1225788010508 transmembrane helices; other site 1225788010509 CotH protein; Region: CotH; pfam08757 1225788010510 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1225788010511 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1225788010512 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1225788010513 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1225788010514 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1225788010515 putative DNA binding site [nucleotide binding]; other site 1225788010516 putative Zn2+ binding site [ion binding]; other site 1225788010517 AsnC family; Region: AsnC_trans_reg; pfam01037 1225788010518 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1225788010519 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1225788010520 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1225788010521 Active_site [active] 1225788010522 LXG domain of WXG superfamily; Region: LXG; pfam04740 1225788010523 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1225788010524 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1225788010525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1225788010526 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1225788010527 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1225788010528 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1225788010529 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1225788010530 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1225788010531 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1225788010532 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1225788010533 Nucleotide binding site [chemical binding]; other site 1225788010534 DTAP/Switch II; other site 1225788010535 Switch I; other site 1225788010536 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1225788010537 Chain length determinant protein; Region: Wzz; cl15801 1225788010538 SWIM zinc finger; Region: SWIM; pfam04434 1225788010539 SNF2 Helicase protein; Region: DUF3670; pfam12419 1225788010540 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1225788010541 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1225788010542 ATP binding site [chemical binding]; other site 1225788010543 putative Mg++ binding site [ion binding]; other site 1225788010544 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1225788010545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1225788010546 nucleotide binding region [chemical binding]; other site 1225788010547 ATP-binding site [chemical binding]; other site 1225788010548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788010549 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1225788010550 active site 1225788010551 motif I; other site 1225788010552 motif II; other site 1225788010553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788010554 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1225788010555 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1225788010556 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1225788010557 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1225788010558 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1225788010559 dimer interface [polypeptide binding]; other site 1225788010560 ssDNA binding site [nucleotide binding]; other site 1225788010561 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1225788010562 YwpF-like protein; Region: YwpF; pfam14183 1225788010563 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1225788010564 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1225788010565 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1225788010566 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788010567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788010568 binding surface 1225788010569 TPR motif; other site 1225788010570 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788010571 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1225788010572 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1225788010573 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1225788010574 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1225788010575 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1225788010576 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1225788010577 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1225788010578 MreB and similar proteins; Region: MreB_like; cd10225 1225788010579 nucleotide binding site [chemical binding]; other site 1225788010580 Mg binding site [ion binding]; other site 1225788010581 putative protofilament interaction site [polypeptide binding]; other site 1225788010582 RodZ interaction site [polypeptide binding]; other site 1225788010583 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1225788010584 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788010585 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1225788010586 putative Zn2+ binding site [ion binding]; other site 1225788010587 putative DNA binding site [nucleotide binding]; other site 1225788010588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788010589 putative substrate translocation pore; other site 1225788010590 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788010591 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1225788010592 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1225788010593 Na binding site [ion binding]; other site 1225788010594 putative substrate binding site [chemical binding]; other site 1225788010595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788010596 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788010597 putative substrate translocation pore; other site 1225788010598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788010599 Isochorismatase family; Region: Isochorismatase; pfam00857 1225788010600 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1225788010601 catalytic triad [active] 1225788010602 conserved cis-peptide bond; other site 1225788010603 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1225788010604 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1225788010605 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1225788010606 cell division protein FtsW; Region: ftsW; TIGR02614 1225788010607 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1225788010608 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1225788010609 active site 1225788010610 VanZ like family; Region: VanZ; pfam04892 1225788010611 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1225788010612 Peptidase family M23; Region: Peptidase_M23; pfam01551 1225788010613 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1225788010614 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788010615 Coenzyme A binding pocket [chemical binding]; other site 1225788010616 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1225788010617 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1225788010618 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1225788010619 putative active site [active] 1225788010620 catalytic site [active] 1225788010621 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1225788010622 putative active site [active] 1225788010623 catalytic site [active] 1225788010624 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1225788010625 Predicted transcriptional regulator [Transcription]; Region: COG1959 1225788010626 Transcriptional regulator; Region: Rrf2; pfam02082 1225788010627 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1225788010628 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1225788010629 subunit interactions [polypeptide binding]; other site 1225788010630 active site 1225788010631 flap region; other site 1225788010632 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1225788010633 gamma-beta subunit interface [polypeptide binding]; other site 1225788010634 alpha-beta subunit interface [polypeptide binding]; other site 1225788010635 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1225788010636 alpha-gamma subunit interface [polypeptide binding]; other site 1225788010637 beta-gamma subunit interface [polypeptide binding]; other site 1225788010638 CsbD-like; Region: CsbD; pfam05532 1225788010639 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788010640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788010641 binding surface 1225788010642 TPR motif; other site 1225788010643 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1225788010644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1225788010645 FeS/SAM binding site; other site 1225788010646 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1225788010647 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1225788010648 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1225788010649 metal ion-dependent adhesion site (MIDAS); other site 1225788010650 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1225788010651 metal ion-dependent adhesion site (MIDAS); other site 1225788010652 Stage II sporulation protein; Region: SpoIID; pfam08486 1225788010653 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1225788010654 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1225788010655 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1225788010656 hinge; other site 1225788010657 active site 1225788010658 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1225788010659 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1225788010660 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1225788010661 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1225788010662 gamma subunit interface [polypeptide binding]; other site 1225788010663 epsilon subunit interface [polypeptide binding]; other site 1225788010664 LBP interface [polypeptide binding]; other site 1225788010665 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1225788010666 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1225788010667 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1225788010668 alpha subunit interaction interface [polypeptide binding]; other site 1225788010669 Walker A motif; other site 1225788010670 ATP binding site [chemical binding]; other site 1225788010671 Walker B motif; other site 1225788010672 inhibitor binding site; inhibition site 1225788010673 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1225788010674 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1225788010675 core domain interface [polypeptide binding]; other site 1225788010676 delta subunit interface [polypeptide binding]; other site 1225788010677 epsilon subunit interface [polypeptide binding]; other site 1225788010678 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1225788010679 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1225788010680 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1225788010681 beta subunit interaction interface [polypeptide binding]; other site 1225788010682 Walker A motif; other site 1225788010683 ATP binding site [chemical binding]; other site 1225788010684 Walker B motif; other site 1225788010685 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1225788010686 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 1225788010687 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1225788010688 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1225788010689 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1225788010690 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1225788010691 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1225788010692 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1225788010693 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1225788010694 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1225788010695 active site 1225788010696 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1225788010697 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1225788010698 dimer interface [polypeptide binding]; other site 1225788010699 active site 1225788010700 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1225788010701 folate binding site [chemical binding]; other site 1225788010702 hypothetical protein; Provisional; Region: PRK13690 1225788010703 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1225788010704 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1225788010705 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1225788010706 active site 1225788010707 Predicted membrane protein [Function unknown]; Region: COG1971 1225788010708 Domain of unknown function DUF; Region: DUF204; pfam02659 1225788010709 Domain of unknown function DUF; Region: DUF204; pfam02659 1225788010710 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1225788010711 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1225788010712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1225788010713 stage II sporulation protein R; Region: spore_II_R; TIGR02837 1225788010714 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1225788010715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788010716 S-adenosylmethionine binding site [chemical binding]; other site 1225788010717 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1225788010718 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1225788010719 RF-1 domain; Region: RF-1; pfam00472 1225788010720 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1225788010721 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1225788010722 putative metal binding site [ion binding]; other site 1225788010723 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1225788010724 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1225788010725 DNA binding residues [nucleotide binding] 1225788010726 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1225788010727 malate dehydrogenase; Provisional; Region: PRK13529 1225788010728 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1225788010729 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1225788010730 NAD(P) binding site [chemical binding]; other site 1225788010731 thymidine kinase; Provisional; Region: PRK04296 1225788010732 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1225788010733 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1225788010734 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1225788010735 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1225788010736 RNA binding site [nucleotide binding]; other site 1225788010737 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1225788010738 multimer interface [polypeptide binding]; other site 1225788010739 Walker A motif; other site 1225788010740 ATP binding site [chemical binding]; other site 1225788010741 Walker B motif; other site 1225788010742 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1225788010743 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1225788010744 putative active site [active] 1225788010745 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1225788010746 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1225788010747 hinge; other site 1225788010748 active site 1225788010749 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1225788010750 active site 1225788010751 intersubunit interactions; other site 1225788010752 catalytic residue [active] 1225788010753 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1225788010754 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1225788010755 intersubunit interface [polypeptide binding]; other site 1225788010756 active site 1225788010757 zinc binding site [ion binding]; other site 1225788010758 Na+ binding site [ion binding]; other site 1225788010759 Response regulator receiver domain; Region: Response_reg; pfam00072 1225788010760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788010761 active site 1225788010762 phosphorylation site [posttranslational modification] 1225788010763 intermolecular recognition site; other site 1225788010764 dimerization interface [polypeptide binding]; other site 1225788010765 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1225788010766 CTP synthetase; Validated; Region: pyrG; PRK05380 1225788010767 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1225788010768 Catalytic site [active] 1225788010769 active site 1225788010770 UTP binding site [chemical binding]; other site 1225788010771 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1225788010772 active site 1225788010773 putative oxyanion hole; other site 1225788010774 catalytic triad [active] 1225788010775 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1225788010776 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1225788010777 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1225788010778 Cysteine-rich domain; Region: CCG; pfam02754 1225788010779 Cysteine-rich domain; Region: CCG; pfam02754 1225788010780 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1225788010781 PLD-like domain; Region: PLDc_2; pfam13091 1225788010782 putative active site [active] 1225788010783 catalytic site [active] 1225788010784 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1225788010785 PLD-like domain; Region: PLDc_2; pfam13091 1225788010786 putative active site [active] 1225788010787 catalytic site [active] 1225788010788 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 1225788010789 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1225788010790 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1225788010791 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1225788010792 Walker A/P-loop; other site 1225788010793 ATP binding site [chemical binding]; other site 1225788010794 Q-loop/lid; other site 1225788010795 ABC transporter signature motif; other site 1225788010796 Walker B; other site 1225788010797 D-loop; other site 1225788010798 H-loop/switch region; other site 1225788010799 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1225788010800 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1225788010801 putative active site [active] 1225788010802 catalytic site [active] 1225788010803 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1225788010804 putative active site [active] 1225788010805 catalytic site [active] 1225788010806 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1225788010807 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1225788010808 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1225788010809 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1225788010810 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1225788010811 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1225788010812 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1225788010813 [4Fe-4S] binding site [ion binding]; other site 1225788010814 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1225788010815 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1225788010816 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1225788010817 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1225788010818 molybdopterin cofactor binding site; other site 1225788010819 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1225788010820 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1225788010821 ligand binding site [chemical binding]; other site 1225788010822 flexible hinge region; other site 1225788010823 YwiC-like protein; Region: YwiC; pfam14256 1225788010824 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1225788010825 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1225788010826 ligand binding site [chemical binding]; other site 1225788010827 flexible hinge region; other site 1225788010828 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1225788010829 putative switch regulator; other site 1225788010830 non-specific DNA interactions [nucleotide binding]; other site 1225788010831 DNA binding site [nucleotide binding] 1225788010832 sequence specific DNA binding site [nucleotide binding]; other site 1225788010833 putative cAMP binding site [chemical binding]; other site 1225788010834 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1225788010835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788010836 putative substrate translocation pore; other site 1225788010837 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1225788010838 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1225788010839 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1225788010840 active site 1225788010841 HIGH motif; other site 1225788010842 KMSK motif region; other site 1225788010843 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1225788010844 tRNA binding surface [nucleotide binding]; other site 1225788010845 anticodon binding site; other site 1225788010846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 1225788010847 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1225788010848 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1225788010849 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1225788010850 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1225788010851 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788010852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1225788010853 binding surface 1225788010854 TPR motif; other site 1225788010855 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788010856 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1225788010857 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1225788010858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1225788010859 non-specific DNA binding site [nucleotide binding]; other site 1225788010860 salt bridge; other site 1225788010861 sequence-specific DNA binding site [nucleotide binding]; other site 1225788010862 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1225788010863 Integral membrane protein DUF95; Region: DUF95; pfam01944 1225788010864 DNA binding residues [nucleotide binding] 1225788010865 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1225788010866 dimerization interface [polypeptide binding]; other site 1225788010867 agmatinase; Region: agmatinase; TIGR01230 1225788010868 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1225788010869 putative active site [active] 1225788010870 Mn binding site [ion binding]; other site 1225788010871 spermidine synthase; Provisional; Region: PRK00811 1225788010872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1225788010873 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1225788010874 Transglycosylase; Region: Transgly; pfam00912 1225788010875 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1225788010876 YwhD family; Region: YwhD; pfam08741 1225788010877 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1225788010878 Peptidase family M50; Region: Peptidase_M50; pfam02163 1225788010879 active site 1225788010880 putative substrate binding region [chemical binding]; other site 1225788010881 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1225788010882 active site 1 [active] 1225788010883 dimer interface [polypeptide binding]; other site 1225788010884 hexamer interface [polypeptide binding]; other site 1225788010885 active site 2 [active] 1225788010886 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1225788010887 dimerization interface [polypeptide binding]; other site 1225788010888 putative DNA binding site [nucleotide binding]; other site 1225788010889 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788010890 putative Zn2+ binding site [ion binding]; other site 1225788010891 amino acid transporter; Region: 2A0306; TIGR00909 1225788010892 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1225788010893 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1225788010894 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1225788010895 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1225788010896 Zn2+ binding site [ion binding]; other site 1225788010897 Mg2+ binding site [ion binding]; other site 1225788010898 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1225788010899 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1225788010900 Predicted transcriptional regulators [Transcription]; Region: COG1695 1225788010901 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1225788010902 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1225788010903 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1225788010904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1225788010905 Walker A/P-loop; other site 1225788010906 ATP binding site [chemical binding]; other site 1225788010907 Q-loop/lid; other site 1225788010908 ABC transporter signature motif; other site 1225788010909 Walker B; other site 1225788010910 D-loop; other site 1225788010911 H-loop/switch region; other site 1225788010912 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1225788010913 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1225788010914 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1225788010915 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788010916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788010917 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1225788010918 putative dimerization interface [polypeptide binding]; other site 1225788010919 Predicted membrane protein [Function unknown]; Region: COG2855 1225788010920 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1225788010921 putative heme peroxidase; Provisional; Region: PRK12276 1225788010922 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1225788010923 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1225788010924 putative NAD(P) binding site [chemical binding]; other site 1225788010925 putative active site [active] 1225788010926 transaminase; Reviewed; Region: PRK08068 1225788010927 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1225788010928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788010929 homodimer interface [polypeptide binding]; other site 1225788010930 catalytic residue [active] 1225788010931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788010932 H+ Antiporter protein; Region: 2A0121; TIGR00900 1225788010933 putative substrate translocation pore; other site 1225788010934 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1225788010935 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1225788010936 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1225788010937 classical (c) SDRs; Region: SDR_c; cd05233 1225788010938 NAD(P) binding site [chemical binding]; other site 1225788010939 active site 1225788010940 Cupin domain; Region: Cupin_2; pfam07883 1225788010941 Cupin domain; Region: Cupin_2; pfam07883 1225788010942 Prephenate dehydratase; Region: PDT; pfam00800 1225788010943 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1225788010944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788010945 putative substrate translocation pore; other site 1225788010946 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1225788010947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788010948 putative substrate translocation pore; other site 1225788010949 S-methylmethionine transporter; Provisional; Region: PRK11387 1225788010950 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1225788010951 putative metal binding site [ion binding]; other site 1225788010952 putative dimer interface [polypeptide binding]; other site 1225788010953 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1225788010954 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1225788010955 Glutamate binding site [chemical binding]; other site 1225788010956 homodimer interface [polypeptide binding]; other site 1225788010957 NAD binding site [chemical binding]; other site 1225788010958 catalytic residues [active] 1225788010959 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1225788010960 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1225788010961 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1225788010962 NAD(P) binding site [chemical binding]; other site 1225788010963 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1225788010964 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1225788010965 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1225788010966 NADP binding site [chemical binding]; other site 1225788010967 active site 1225788010968 putative substrate binding site [chemical binding]; other site 1225788010969 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1225788010970 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1225788010971 NAD binding site [chemical binding]; other site 1225788010972 substrate binding site [chemical binding]; other site 1225788010973 homodimer interface [polypeptide binding]; other site 1225788010974 active site 1225788010975 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1225788010976 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1225788010977 substrate binding site; other site 1225788010978 tetramer interface; other site 1225788010979 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1225788010980 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1225788010981 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1225788010982 ligand binding site; other site 1225788010983 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1225788010984 NeuB family; Region: NeuB; pfam03102 1225788010985 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1225788010986 NeuB binding interface [polypeptide binding]; other site 1225788010987 putative substrate binding site [chemical binding]; other site 1225788010988 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1225788010989 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788010990 Coenzyme A binding pocket [chemical binding]; other site 1225788010991 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1225788010992 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1225788010993 inhibitor-cofactor binding pocket; inhibition site 1225788010994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788010995 catalytic residue [active] 1225788010996 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1225788010997 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1225788010998 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1225788010999 active site 1225788011000 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1225788011001 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1225788011002 Permease family; Region: Xan_ur_permease; pfam00860 1225788011003 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1225788011004 ligand binding site [chemical binding]; other site 1225788011005 active site 1225788011006 UGI interface [polypeptide binding]; other site 1225788011007 catalytic site [active] 1225788011008 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1225788011009 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1225788011010 active site 1225788011011 Predicted transcriptional regulators [Transcription]; Region: COG1695 1225788011012 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1225788011013 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1225788011014 dimer interface [polypeptide binding]; other site 1225788011015 substrate binding site [chemical binding]; other site 1225788011016 ATP binding site [chemical binding]; other site 1225788011017 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1225788011018 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1225788011019 substrate binding [chemical binding]; other site 1225788011020 active site 1225788011021 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1225788011022 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1225788011023 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1225788011024 active site turn [active] 1225788011025 phosphorylation site [posttranslational modification] 1225788011026 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1225788011027 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1225788011028 CAT RNA binding domain; Region: CAT_RBD; smart01061 1225788011029 PRD domain; Region: PRD; pfam00874 1225788011030 PRD domain; Region: PRD; pfam00874 1225788011031 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1225788011032 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1225788011033 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1225788011034 putative active site [active] 1225788011035 catalytic triad [active] 1225788011036 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1225788011037 PA/protease domain interface [polypeptide binding]; other site 1225788011038 putative integrin binding motif; other site 1225788011039 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1225788011040 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1225788011041 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1225788011042 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1225788011043 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1225788011044 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1225788011045 HTH-like domain; Region: HTH_21; pfam13276 1225788011046 Integrase core domain; Region: rve; pfam00665 1225788011047 Integrase core domain; Region: rve_3; pfam13683 1225788011048 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1225788011049 dimer interface [polypeptide binding]; other site 1225788011050 FMN binding site [chemical binding]; other site 1225788011051 NADPH bind site [chemical binding]; other site 1225788011052 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1225788011053 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1225788011054 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788011055 Coenzyme A binding pocket [chemical binding]; other site 1225788011056 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1225788011057 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1225788011058 Subunit I/III interface [polypeptide binding]; other site 1225788011059 Subunit III/IV interface [polypeptide binding]; other site 1225788011060 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1225788011061 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1225788011062 D-pathway; other site 1225788011063 Putative ubiquinol binding site [chemical binding]; other site 1225788011064 Low-spin heme (heme b) binding site [chemical binding]; other site 1225788011065 Putative water exit pathway; other site 1225788011066 Binuclear center (heme o3/CuB) [ion binding]; other site 1225788011067 K-pathway; other site 1225788011068 Putative proton exit pathway; other site 1225788011069 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1225788011070 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1225788011071 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1225788011072 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1225788011073 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1225788011074 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1225788011075 potential frameshift: common BLAST hit: gi|154687945|ref|YP_001423106.1| galactokinase 1225788011076 Predicted membrane protein [Function unknown]; Region: COG2246 1225788011077 GtrA-like protein; Region: GtrA; pfam04138 1225788011078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788011079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788011080 Anti-repressor SinI; Region: SinI; pfam08671 1225788011081 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1225788011082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788011083 S-adenosylmethionine binding site [chemical binding]; other site 1225788011084 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1225788011085 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1225788011086 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1225788011087 catalytic residues [active] 1225788011088 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1225788011089 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1225788011090 thiamine phosphate binding site [chemical binding]; other site 1225788011091 active site 1225788011092 pyrophosphate binding site [ion binding]; other site 1225788011093 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1225788011094 substrate binding site [chemical binding]; other site 1225788011095 multimerization interface [polypeptide binding]; other site 1225788011096 ATP binding site [chemical binding]; other site 1225788011097 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788011098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788011099 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1225788011100 putative dimerization interface [polypeptide binding]; other site 1225788011101 holin-like protein; Validated; Region: PRK01658 1225788011102 TIGR00659 family protein; Region: TIGR00659 1225788011103 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1225788011104 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1225788011105 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1225788011106 DNA binding residues [nucleotide binding] 1225788011107 dimer interface [polypeptide binding]; other site 1225788011108 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1225788011109 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 1225788011110 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1225788011111 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1225788011112 putative RNA binding site [nucleotide binding]; other site 1225788011113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788011114 S-adenosylmethionine binding site [chemical binding]; other site 1225788011115 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1225788011116 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1225788011117 active site 1225788011118 metal binding site [ion binding]; metal-binding site 1225788011119 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1225788011120 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1225788011121 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1225788011122 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1225788011123 active site 1225788011124 catalytic residues [active] 1225788011125 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1225788011126 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1225788011127 Ligand binding site; other site 1225788011128 metal-binding site 1225788011129 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1225788011130 synthetase active site [active] 1225788011131 NTP binding site [chemical binding]; other site 1225788011132 metal binding site [ion binding]; metal-binding site 1225788011133 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1225788011134 UbiA prenyltransferase family; Region: UbiA; pfam01040 1225788011135 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1225788011136 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1225788011137 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1225788011138 acyl-activating enzyme (AAE) consensus motif; other site 1225788011139 AMP binding site [chemical binding]; other site 1225788011140 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1225788011141 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1225788011142 potential frameshift: common BLAST hit: gi|384170575|ref|YP_005551953.1| undecaprenol-phosphate-poly(glycerophosphate chain) D-alanine 1225788011143 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1225788011144 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1225788011145 homodimer interface [polypeptide binding]; other site 1225788011146 substrate-cofactor binding pocket; other site 1225788011147 catalytic residue [active] 1225788011148 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1225788011149 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1225788011150 NAD binding site [chemical binding]; other site 1225788011151 sugar binding site [chemical binding]; other site 1225788011152 divalent metal binding site [ion binding]; other site 1225788011153 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1225788011154 dimer interface [polypeptide binding]; other site 1225788011155 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1225788011156 methionine cluster; other site 1225788011157 active site 1225788011158 phosphorylation site [posttranslational modification] 1225788011159 metal binding site [ion binding]; metal-binding site 1225788011160 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1225788011161 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1225788011162 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1225788011163 active site 1225788011164 P-loop; other site 1225788011165 phosphorylation site [posttranslational modification] 1225788011166 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1225788011167 HTH domain; Region: HTH_11; pfam08279 1225788011168 Mga helix-turn-helix domain; Region: Mga; pfam05043 1225788011169 PRD domain; Region: PRD; pfam00874 1225788011170 PRD domain; Region: PRD; pfam00874 1225788011171 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1225788011172 active site 1225788011173 P-loop; other site 1225788011174 phosphorylation site [posttranslational modification] 1225788011175 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1225788011176 active site 1225788011177 phosphorylation site [posttranslational modification] 1225788011178 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1225788011179 active site 1225788011180 DNA binding site [nucleotide binding] 1225788011181 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1225788011182 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1225788011183 ABC-ATPase subunit interface; other site 1225788011184 dimer interface [polypeptide binding]; other site 1225788011185 putative PBP binding regions; other site 1225788011186 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1225788011187 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1225788011188 ABC-ATPase subunit interface; other site 1225788011189 dimer interface [polypeptide binding]; other site 1225788011190 putative PBP binding regions; other site 1225788011191 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1225788011192 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1225788011193 intersubunit interface [polypeptide binding]; other site 1225788011194 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1225788011195 dimerization interface [polypeptide binding]; other site 1225788011196 putative DNA binding site [nucleotide binding]; other site 1225788011197 putative Zn2+ binding site [ion binding]; other site 1225788011198 arsenical pump membrane protein; Provisional; Region: PRK15445 1225788011199 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1225788011200 transmembrane helices; other site 1225788011201 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1225788011202 active site 1225788011203 P-loop; other site 1225788011204 phosphorylation site [posttranslational modification] 1225788011205 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1225788011206 active site 1225788011207 methionine cluster; other site 1225788011208 phosphorylation site [posttranslational modification] 1225788011209 metal binding site [ion binding]; metal-binding site 1225788011210 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1225788011211 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1225788011212 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1225788011213 beta-galactosidase; Region: BGL; TIGR03356 1225788011214 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1225788011215 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1225788011216 nucleotide binding site [chemical binding]; other site 1225788011217 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1225788011218 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1225788011219 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1225788011220 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1225788011221 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1225788011222 tetramer interface [polypeptide binding]; other site 1225788011223 heme binding pocket [chemical binding]; other site 1225788011224 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1225788011225 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1225788011226 active site 1225788011227 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1225788011228 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1225788011229 Na binding site [ion binding]; other site 1225788011230 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1225788011231 putative substrate binding site [chemical binding]; other site 1225788011232 putative ATP binding site [chemical binding]; other site 1225788011233 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1225788011234 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1225788011235 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1225788011236 Walker A/P-loop; other site 1225788011237 ATP binding site [chemical binding]; other site 1225788011238 Q-loop/lid; other site 1225788011239 ABC transporter signature motif; other site 1225788011240 Walker B; other site 1225788011241 D-loop; other site 1225788011242 H-loop/switch region; other site 1225788011243 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1225788011244 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1225788011245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1225788011246 ATP binding site [chemical binding]; other site 1225788011247 Q-loop/lid; other site 1225788011248 ABC transporter signature motif; other site 1225788011249 Walker B; other site 1225788011250 D-loop; other site 1225788011251 H-loop/switch region; other site 1225788011252 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1225788011253 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1225788011254 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1225788011255 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1225788011256 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1225788011257 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1225788011258 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1225788011259 putative active site [active] 1225788011260 putative metal binding site [ion binding]; other site 1225788011261 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1225788011262 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1225788011263 Walker A/P-loop; other site 1225788011264 ATP binding site [chemical binding]; other site 1225788011265 Q-loop/lid; other site 1225788011266 ABC transporter signature motif; other site 1225788011267 Walker B; other site 1225788011268 D-loop; other site 1225788011269 H-loop/switch region; other site 1225788011270 TOBE domain; Region: TOBE; pfam03459 1225788011271 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1225788011272 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1225788011273 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1225788011274 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1225788011275 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1225788011276 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1225788011277 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1225788011278 UDP-glucose 4-epimerase; Region: PLN02240 1225788011279 NAD binding site [chemical binding]; other site 1225788011280 homodimer interface [polypeptide binding]; other site 1225788011281 active site 1225788011282 substrate binding site [chemical binding]; other site 1225788011283 peptidase T; Region: peptidase-T; TIGR01882 1225788011284 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1225788011285 metal binding site [ion binding]; metal-binding site 1225788011286 dimer interface [polypeptide binding]; other site 1225788011287 Tubby C 2; Region: Tub_2; cl02043 1225788011288 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1225788011289 substrate binding site [chemical binding]; other site 1225788011290 THF binding site; other site 1225788011291 zinc-binding site [ion binding]; other site 1225788011292 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1225788011293 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1225788011294 nucleoside transporter; Region: nupC; TIGR00804 1225788011295 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1225788011296 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1225788011297 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1225788011298 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1225788011299 hydroperoxidase II; Provisional; Region: katE; PRK11249 1225788011300 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1225788011301 tetramer interface [polypeptide binding]; other site 1225788011302 heme binding pocket [chemical binding]; other site 1225788011303 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1225788011304 domain interactions; other site 1225788011305 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1225788011306 Citrate transporter; Region: CitMHS; pfam03600 1225788011307 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1225788011308 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1225788011309 active site 1225788011310 active site 1225788011311 catalytic residues [active] 1225788011312 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1225788011313 CAT RNA binding domain; Region: CAT_RBD; smart01061 1225788011314 PRD domain; Region: PRD; pfam00874 1225788011315 PRD domain; Region: PRD; pfam00874 1225788011316 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1225788011317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788011318 putative substrate translocation pore; other site 1225788011319 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1225788011320 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1225788011321 ATP binding site [chemical binding]; other site 1225788011322 Mg++ binding site [ion binding]; other site 1225788011323 motif III; other site 1225788011324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1225788011325 nucleotide binding region [chemical binding]; other site 1225788011326 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1225788011327 RNA binding site [nucleotide binding]; other site 1225788011328 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1225788011329 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 1225788011330 YxiJ-like protein; Region: YxiJ; pfam14176 1225788011331 RHS Repeat; Region: RHS_repeat; pfam05593 1225788011332 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1225788011333 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1225788011334 RHS Repeat; Region: RHS_repeat; pfam05593 1225788011335 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1225788011336 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1225788011337 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1225788011338 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1225788011339 Amb_all domain; Region: Amb_all; smart00656 1225788011340 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1225788011341 EamA-like transporter family; Region: EamA; pfam00892 1225788011342 EamA-like transporter family; Region: EamA; pfam00892 1225788011343 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1225788011344 Ligand Binding Site [chemical binding]; other site 1225788011345 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1225788011346 beta-galactosidase; Region: BGL; TIGR03356 1225788011347 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1225788011348 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1225788011349 active site turn [active] 1225788011350 phosphorylation site [posttranslational modification] 1225788011351 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1225788011352 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1225788011353 HPr interaction site; other site 1225788011354 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1225788011355 active site 1225788011356 phosphorylation site [posttranslational modification] 1225788011357 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1225788011358 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1225788011359 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1225788011360 cofactor binding site; other site 1225788011361 DNA binding site [nucleotide binding] 1225788011362 substrate interaction site [chemical binding]; other site 1225788011363 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1225788011364 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1225788011365 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1225788011366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788011367 ATP binding site [chemical binding]; other site 1225788011368 G-X-G motif; other site 1225788011369 Z1 domain; Region: Z1; pfam10593 1225788011370 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 1225788011371 AIPR protein; Region: AIPR; pfam10592 1225788011372 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1225788011373 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1225788011374 substrate binding site [chemical binding]; other site 1225788011375 active site 1225788011376 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1225788011377 hexamer interface [polypeptide binding]; other site 1225788011378 RNA binding site [nucleotide binding]; other site 1225788011379 Histidine-zinc binding site [chemical binding]; other site 1225788011380 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1225788011381 active sites [active] 1225788011382 tetramer interface [polypeptide binding]; other site 1225788011383 urocanate hydratase; Provisional; Region: PRK05414 1225788011384 imidazolonepropionase; Validated; Region: PRK09356 1225788011385 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1225788011386 active site 1225788011387 Agmatinase-like family; Region: Agmatinase-like; cd09990 1225788011388 agmatinase; Region: agmatinase; TIGR01230 1225788011389 active site 1225788011390 oligomer interface [polypeptide binding]; other site 1225788011391 Mn binding site [ion binding]; other site 1225788011392 S-methylmethionine transporter; Provisional; Region: PRK11387 1225788011393 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1225788011394 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1225788011395 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1225788011396 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1225788011397 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1225788011398 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1225788011399 Nucleoside recognition; Region: Gate; pfam07670 1225788011400 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1225788011401 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1225788011402 intersubunit interface [polypeptide binding]; other site 1225788011403 active site 1225788011404 catalytic residue [active] 1225788011405 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1225788011406 MarR family; Region: MarR_2; pfam12802 1225788011407 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1225788011408 sugar phosphate phosphatase; Provisional; Region: PRK10513 1225788011409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788011410 active site 1225788011411 motif I; other site 1225788011412 motif II; other site 1225788011413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1225788011414 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1225788011415 SlyX; Region: SlyX; cl01090 1225788011416 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1225788011417 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1225788011418 putative ligand binding residues [chemical binding]; other site 1225788011419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1225788011420 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1225788011421 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1225788011422 Walker A/P-loop; other site 1225788011423 ATP binding site [chemical binding]; other site 1225788011424 Q-loop/lid; other site 1225788011425 ABC transporter signature motif; other site 1225788011426 Walker B; other site 1225788011427 D-loop; other site 1225788011428 H-loop/switch region; other site 1225788011429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1225788011430 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1225788011431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788011432 ATP binding site [chemical binding]; other site 1225788011433 Mg2+ binding site [ion binding]; other site 1225788011434 G-X-G motif; other site 1225788011435 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1225788011436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788011437 active site 1225788011438 phosphorylation site [posttranslational modification] 1225788011439 intermolecular recognition site; other site 1225788011440 dimerization interface [polypeptide binding]; other site 1225788011441 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1225788011442 DNA binding site [nucleotide binding] 1225788011443 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1225788011444 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1225788011445 intersubunit interface [polypeptide binding]; other site 1225788011446 active site 1225788011447 zinc binding site [ion binding]; other site 1225788011448 Na+ binding site [ion binding]; other site 1225788011449 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1225788011450 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1225788011451 Metal-binding active site; metal-binding site 1225788011452 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1225788011453 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1225788011454 DNA interaction; other site 1225788011455 Metal-binding active site; metal-binding site 1225788011456 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1225788011457 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1225788011458 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1225788011459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788011460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788011461 putative substrate translocation pore; other site 1225788011462 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1225788011463 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1225788011464 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1225788011465 PYR/PP interface [polypeptide binding]; other site 1225788011466 dimer interface [polypeptide binding]; other site 1225788011467 TPP binding site [chemical binding]; other site 1225788011468 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1225788011469 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1225788011470 TPP-binding site; other site 1225788011471 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1225788011472 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1225788011473 substrate binding site [chemical binding]; other site 1225788011474 ATP binding site [chemical binding]; other site 1225788011475 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1225788011476 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1225788011477 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1225788011478 tetrameric interface [polypeptide binding]; other site 1225788011479 NAD binding site [chemical binding]; other site 1225788011480 catalytic residues [active] 1225788011481 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1225788011482 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1225788011483 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1225788011484 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1225788011485 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1225788011486 active site 1225788011487 catalytic tetrad [active] 1225788011488 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1225788011489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788011490 putative substrate translocation pore; other site 1225788011491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788011492 heat shock protein 90; Provisional; Region: PRK05218 1225788011493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788011494 ATP binding site [chemical binding]; other site 1225788011495 Mg2+ binding site [ion binding]; other site 1225788011496 G-X-G motif; other site 1225788011497 short chain dehydrogenase; Validated; Region: PRK08589 1225788011498 classical (c) SDRs; Region: SDR_c; cd05233 1225788011499 NAD(P) binding site [chemical binding]; other site 1225788011500 active site 1225788011501 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1225788011502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788011503 active site 1225788011504 phosphorylation site [posttranslational modification] 1225788011505 intermolecular recognition site; other site 1225788011506 dimerization interface [polypeptide binding]; other site 1225788011507 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1225788011508 DNA binding residues [nucleotide binding] 1225788011509 dimerization interface [polypeptide binding]; other site 1225788011510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1225788011511 Histidine kinase; Region: HisKA_3; pfam07730 1225788011512 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1225788011513 ATP binding site [chemical binding]; other site 1225788011514 Mg2+ binding site [ion binding]; other site 1225788011515 G-X-G motif; other site 1225788011516 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1225788011517 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1225788011518 putative di-iron ligands [ion binding]; other site 1225788011519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788011520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788011521 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1225788011522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1225788011523 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1225788011524 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1225788011525 NAD(P) binding site [chemical binding]; other site 1225788011526 catalytic residues [active] 1225788011527 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1225788011528 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1225788011529 Trp docking motif [polypeptide binding]; other site 1225788011530 active site 1225788011531 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1225788011532 putative DNA binding site [nucleotide binding]; other site 1225788011533 dimerization interface [polypeptide binding]; other site 1225788011534 putative Zn2+ binding site [ion binding]; other site 1225788011535 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1225788011536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788011537 putative substrate translocation pore; other site 1225788011538 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1225788011539 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1225788011540 active site 1225788011541 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1225788011542 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1225788011543 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1225788011544 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1225788011545 Restriction endonuclease; Region: Mrr_cat; pfam04471 1225788011546 peroxiredoxin; Region: AhpC; TIGR03137 1225788011547 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1225788011548 dimer interface [polypeptide binding]; other site 1225788011549 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1225788011550 catalytic triad [active] 1225788011551 peroxidatic and resolving cysteines [active] 1225788011552 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1225788011553 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1225788011554 catalytic residue [active] 1225788011555 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1225788011556 catalytic residues [active] 1225788011557 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1225788011558 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1225788011559 Fic family protein [Function unknown]; Region: COG3177 1225788011560 Fic/DOC family; Region: Fic; pfam02661 1225788011561 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1225788011562 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1225788011563 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1225788011564 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1225788011565 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1225788011566 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1225788011567 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1225788011568 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1225788011569 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1225788011570 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1225788011571 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1225788011572 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1225788011573 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1225788011574 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1225788011575 Ligand binding site; other site 1225788011576 metal-binding site 1225788011577 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1225788011578 Uncharacterized protein conserved in bacteria [Carbohydrate transport and metabolism]; Region: Fbp; COG3855 1225788011579 Protein of unknown function DUF262; Region: DUF262; pfam03235 1225788011580 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1225788011581 Divergent AAA domain; Region: AAA_4; pfam04326 1225788011582 Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]; Region: CDC6; COG1474 1225788011583 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1225788011584 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1225788011585 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1225788011586 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1225788011587 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1225788011588 active site 1225788011589 catalytic tetrad [active] 1225788011590 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1225788011591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788011592 Coenzyme A binding pocket [chemical binding]; other site 1225788011593 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788011594 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1225788011595 Arginase family; Region: Arginase; cd09989 1225788011596 agmatinase; Region: agmatinase; TIGR01230 1225788011597 active site 1225788011598 Mn binding site [ion binding]; other site 1225788011599 oligomer interface [polypeptide binding]; other site 1225788011600 S-methylmethionine transporter; Provisional; Region: PRK11387 1225788011601 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1225788011602 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1225788011603 inhibitor-cofactor binding pocket; inhibition site 1225788011604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788011605 catalytic residue [active] 1225788011606 Predicted integral membrane protein [Function unknown]; Region: COG5658 1225788011607 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1225788011608 SdpI/YhfL protein family; Region: SdpI; pfam13630 1225788011609 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1225788011610 dimerization interface [polypeptide binding]; other site 1225788011611 putative DNA binding site [nucleotide binding]; other site 1225788011612 putative Zn2+ binding site [ion binding]; other site 1225788011613 PAS domain; Region: PAS_9; pfam13426 1225788011614 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1225788011615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1225788011616 Walker A motif; other site 1225788011617 ATP binding site [chemical binding]; other site 1225788011618 Walker B motif; other site 1225788011619 arginine finger; other site 1225788011620 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1225788011621 Cupin-like domain; Region: Cupin_8; pfam13621 1225788011622 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1225788011623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1225788011624 Walker A/P-loop; other site 1225788011625 ATP binding site [chemical binding]; other site 1225788011626 Q-loop/lid; other site 1225788011627 ABC transporter signature motif; other site 1225788011628 Walker B; other site 1225788011629 D-loop; other site 1225788011630 H-loop/switch region; other site 1225788011631 ABC transporter; Region: ABC_tran_2; pfam12848 1225788011632 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1225788011633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788011634 putative substrate translocation pore; other site 1225788011635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788011636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1225788011637 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1225788011638 dimerization interface [polypeptide binding]; other site 1225788011639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788011640 dimer interface [polypeptide binding]; other site 1225788011641 phosphorylation site [posttranslational modification] 1225788011642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788011643 ATP binding site [chemical binding]; other site 1225788011644 Mg2+ binding site [ion binding]; other site 1225788011645 G-X-G motif; other site 1225788011646 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1225788011647 DNA binding site [nucleotide binding] 1225788011648 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1225788011649 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1225788011650 protein binding site [polypeptide binding]; other site 1225788011651 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1225788011652 YycH protein; Region: YycI; cl02015 1225788011653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1225788011654 YycH protein; Region: YycH; pfam07435 1225788011655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1225788011656 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1225788011657 dimerization interface [polypeptide binding]; other site 1225788011658 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1225788011659 putative active site [active] 1225788011660 heme pocket [chemical binding]; other site 1225788011661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1225788011662 dimer interface [polypeptide binding]; other site 1225788011663 phosphorylation site [posttranslational modification] 1225788011664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1225788011665 ATP binding site [chemical binding]; other site 1225788011666 Mg2+ binding site [ion binding]; other site 1225788011667 G-X-G motif; other site 1225788011668 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1225788011669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1225788011670 active site 1225788011671 phosphorylation site [posttranslational modification] 1225788011672 intermolecular recognition site; other site 1225788011673 dimerization interface [polypeptide binding]; other site 1225788011674 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1225788011675 DNA binding site [nucleotide binding] 1225788011676 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1225788011677 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1225788011678 GDP-binding site [chemical binding]; other site 1225788011679 ACT binding site; other site 1225788011680 IMP binding site; other site 1225788011681 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1225788011682 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1225788011683 active site 1225788011684 replicative DNA helicase; Provisional; Region: PRK05748 1225788011685 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1225788011686 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1225788011687 Walker A motif; other site 1225788011688 ATP binding site [chemical binding]; other site 1225788011689 Walker B motif; other site 1225788011690 DNA binding loops [nucleotide binding] 1225788011691 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1225788011692 YycC-like protein; Region: YycC; pfam14174 1225788011693 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1225788011694 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1225788011695 Phosphotransferase enzyme family; Region: APH; pfam01636 1225788011696 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1225788011697 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1225788011698 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1225788011699 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1225788011700 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1225788011701 active site 1225788011702 substrate binding site [chemical binding]; other site 1225788011703 ATP binding site [chemical binding]; other site 1225788011704 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1225788011705 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1225788011706 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1225788011707 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1225788011708 diguanylate cyclase; Region: GGDEF; smart00267 1225788011709 DHH family; Region: DHH; pfam01368 1225788011710 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 1225788011711 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1225788011712 Predicted transcriptional regulators [Transcription]; Region: COG1733 1225788011713 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1225788011714 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1225788011715 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1225788011716 DHHA2 domain; Region: DHHA2; pfam02833 1225788011717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1225788011718 HTH-like domain; Region: HTH_21; pfam13276 1225788011719 Integrase core domain; Region: rve; pfam00665 1225788011720 Integrase core domain; Region: rve_3; pfam13683 1225788011721 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1225788011722 EamA-like transporter family; Region: EamA; pfam00892 1225788011723 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1225788011724 EamA-like transporter family; Region: EamA; pfam00892 1225788011725 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1225788011726 active site 1225788011727 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1225788011728 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1225788011729 substrate binding [chemical binding]; other site 1225788011730 active site 1225788011731 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1225788011732 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1225788011733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788011734 DNA-binding site [nucleotide binding]; DNA binding site 1225788011735 FCD domain; Region: FCD; pfam07729 1225788011736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1225788011737 DinB superfamily; Region: DinB_2; pfam12867 1225788011738 H+ Antiporter protein; Region: 2A0121; TIGR00900 1225788011739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788011740 putative substrate translocation pore; other site 1225788011741 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788011742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788011743 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1225788011744 dimerization interface [polypeptide binding]; other site 1225788011745 LysE type translocator; Region: LysE; cl00565 1225788011746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788011747 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1225788011748 putative substrate translocation pore; other site 1225788011749 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788011750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788011751 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1225788011752 putative dimerization interface [polypeptide binding]; other site 1225788011753 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1225788011754 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1225788011755 dimer interface [polypeptide binding]; other site 1225788011756 FMN binding site [chemical binding]; other site 1225788011757 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788011758 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1225788011759 putative DNA binding site [nucleotide binding]; other site 1225788011760 putative Zn2+ binding site [ion binding]; other site 1225788011761 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1225788011762 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1225788011763 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1225788011764 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1225788011765 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1225788011766 MarR family; Region: MarR; pfam01047 1225788011767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788011768 Coenzyme A binding pocket [chemical binding]; other site 1225788011769 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1225788011770 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1225788011771 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1225788011772 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1225788011773 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1225788011774 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1225788011775 putative dimerization interface [polypeptide binding]; other site 1225788011776 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1225788011777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1225788011778 NAD(P) binding site [chemical binding]; other site 1225788011779 active site 1225788011780 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1225788011781 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1225788011782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1225788011783 DNA-binding site [nucleotide binding]; DNA binding site 1225788011784 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1225788011785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1225788011786 homodimer interface [polypeptide binding]; other site 1225788011787 catalytic residue [active] 1225788011788 EamA-like transporter family; Region: EamA; pfam00892 1225788011789 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1225788011790 EamA-like transporter family; Region: EamA; pfam00892 1225788011791 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1225788011792 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1225788011793 catalytic residues [active] 1225788011794 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1225788011795 CAAX protease self-immunity; Region: Abi; pfam02517 1225788011796 benzoate transport; Region: 2A0115; TIGR00895 1225788011797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788011798 putative substrate translocation pore; other site 1225788011799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1225788011800 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1225788011801 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1225788011802 putative metal binding site [ion binding]; other site 1225788011803 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1225788011804 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1225788011805 DNA binding site [nucleotide binding] 1225788011806 domain linker motif; other site 1225788011807 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1225788011808 putative dimerization interface [polypeptide binding]; other site 1225788011809 putative ligand binding site [chemical binding]; other site 1225788011810 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1225788011811 active site 1225788011812 putative catalytic site [active] 1225788011813 DNA binding site [nucleotide binding] 1225788011814 putative phosphate binding site [ion binding]; other site 1225788011815 metal binding site A [ion binding]; metal-binding site 1225788011816 AP binding site [nucleotide binding]; other site 1225788011817 metal binding site B [ion binding]; metal-binding site 1225788011818 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1225788011819 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1225788011820 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1225788011821 DNA binding site [nucleotide binding] 1225788011822 active site 1225788011823 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1225788011824 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1225788011825 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1225788011826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1225788011827 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1225788011828 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1225788011829 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1225788011830 dimer interface [polypeptide binding]; other site 1225788011831 ssDNA binding site [nucleotide binding]; other site 1225788011832 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1225788011833 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1225788011834 GTP-binding protein YchF; Reviewed; Region: PRK09601 1225788011835 YchF GTPase; Region: YchF; cd01900 1225788011836 G1 box; other site 1225788011837 GTP/Mg2+ binding site [chemical binding]; other site 1225788011838 Switch I region; other site 1225788011839 G2 box; other site 1225788011840 Switch II region; other site 1225788011841 G3 box; other site 1225788011842 G4 box; other site 1225788011843 G5 box; other site 1225788011844 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1225788011845 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1225788011846 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1225788011847 putative [4Fe-4S] binding site [ion binding]; other site 1225788011848 putative molybdopterin cofactor binding site [chemical binding]; other site 1225788011849 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1225788011850 molybdopterin cofactor binding site; other site 1225788011851 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1225788011852 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1225788011853 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1225788011854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1225788011855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1225788011856 Coenzyme A binding pocket [chemical binding]; other site 1225788011857 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1225788011858 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1225788011859 ParB-like nuclease domain; Region: ParB; smart00470 1225788011860 KorB domain; Region: KorB; pfam08535 1225788011861 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1225788011862 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1225788011863 P-loop; other site 1225788011864 Magnesium ion binding site [ion binding]; other site 1225788011865 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1225788011866 Magnesium ion binding site [ion binding]; other site 1225788011867 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1225788011868 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1225788011869 ParB-like nuclease domain; Region: ParB; smart00470 1225788011870 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1225788011871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1225788011872 S-adenosylmethionine binding site [chemical binding]; other site 1225788011873 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1225788011874 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1225788011875 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1225788011876 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1225788011877 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1225788011878 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1225788011879 G1 box; other site 1225788011880 GTP/Mg2+ binding site [chemical binding]; other site 1225788011881 Switch I region; other site 1225788011882 G2 box; other site 1225788011883 Switch II region; other site 1225788011884 G3 box; other site 1225788011885 G4 box; other site 1225788011886 G5 box; other site 1225788011887 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1225788011888 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1225788011889 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1225788011890 G-X-X-G motif; other site 1225788011891 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1225788011892 RxxxH motif; other site 1225788011893 OxaA-like protein precursor; Validated; Region: PRK02944 1225788011894 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1225788011895 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1225788011896 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399