-- dump date 20140618_211315 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1114958000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1114958000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1114958000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958000004 Walker A motif; other site 1114958000005 ATP binding site [chemical binding]; other site 1114958000006 Walker B motif; other site 1114958000007 arginine finger; other site 1114958000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1114958000009 DnaA box-binding interface [nucleotide binding]; other site 1114958000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1114958000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1114958000012 putative DNA binding surface [nucleotide binding]; other site 1114958000013 dimer interface [polypeptide binding]; other site 1114958000014 beta-clamp/clamp loader binding surface; other site 1114958000015 beta-clamp/translesion DNA polymerase binding surface; other site 1114958000016 S4 domain; Region: S4_2; pfam13275 1114958000017 recombination protein F; Reviewed; Region: recF; PRK00064 1114958000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1114958000019 Walker A/P-loop; other site 1114958000020 ATP binding site [chemical binding]; other site 1114958000021 Q-loop/lid; other site 1114958000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958000023 ABC transporter signature motif; other site 1114958000024 Walker B; other site 1114958000025 D-loop; other site 1114958000026 H-loop/switch region; other site 1114958000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1114958000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958000029 ATP binding site [chemical binding]; other site 1114958000030 Mg2+ binding site [ion binding]; other site 1114958000031 G-X-G motif; other site 1114958000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1114958000033 anchoring element; other site 1114958000034 dimer interface [polypeptide binding]; other site 1114958000035 ATP binding site [chemical binding]; other site 1114958000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1114958000037 active site 1114958000038 putative metal-binding site [ion binding]; other site 1114958000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1114958000040 DNA gyrase subunit A; Validated; Region: PRK05560 1114958000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1114958000042 CAP-like domain; other site 1114958000043 active site 1114958000044 primary dimer interface [polypeptide binding]; other site 1114958000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958000051 YaaC-like Protein; Region: YaaC; pfam14175 1114958000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1114958000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114958000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1114958000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1114958000056 active site 1114958000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1114958000058 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1114958000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1114958000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1114958000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1114958000062 active site 1114958000063 multimer interface [polypeptide binding]; other site 1114958000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1114958000065 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1114958000066 predicted active site [active] 1114958000067 catalytic triad [active] 1114958000068 seryl-tRNA synthetase; Provisional; Region: PRK05431 1114958000069 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1114958000070 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1114958000071 dimer interface [polypeptide binding]; other site 1114958000072 active site 1114958000073 motif 1; other site 1114958000074 motif 2; other site 1114958000075 motif 3; other site 1114958000076 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1114958000077 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1114958000078 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1114958000079 Substrate-binding site [chemical binding]; other site 1114958000080 Substrate specificity [chemical binding]; other site 1114958000081 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1114958000082 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1114958000083 Substrate-binding site [chemical binding]; other site 1114958000084 Substrate specificity [chemical binding]; other site 1114958000085 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1114958000086 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958000087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958000088 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1114958000089 active site 1114958000090 Isochorismatase family; Region: Isochorismatase; pfam00857 1114958000091 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1114958000092 catalytic triad [active] 1114958000093 conserved cis-peptide bond; other site 1114958000094 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1114958000095 nucleoside/Zn binding site; other site 1114958000096 dimer interface [polypeptide binding]; other site 1114958000097 catalytic motif [active] 1114958000098 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1114958000099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958000100 Walker A motif; other site 1114958000101 ATP binding site [chemical binding]; other site 1114958000102 Walker B motif; other site 1114958000103 arginine finger; other site 1114958000104 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1114958000105 hypothetical protein; Validated; Region: PRK00153 1114958000106 recombination protein RecR; Reviewed; Region: recR; PRK00076 1114958000107 RecR protein; Region: RecR; pfam02132 1114958000108 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1114958000109 putative active site [active] 1114958000110 putative metal-binding site [ion binding]; other site 1114958000111 tetramer interface [polypeptide binding]; other site 1114958000112 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1114958000113 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 1114958000114 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1114958000115 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 1114958000116 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1114958000117 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1114958000118 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1114958000119 homodimer interface [polypeptide binding]; other site 1114958000120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958000121 catalytic residue [active] 1114958000122 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1114958000123 thymidylate kinase; Validated; Region: tmk; PRK00698 1114958000124 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1114958000125 TMP-binding site; other site 1114958000126 ATP-binding site [chemical binding]; other site 1114958000127 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1114958000128 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1114958000129 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1114958000130 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1114958000131 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1114958000132 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1114958000133 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1114958000134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958000135 S-adenosylmethionine binding site [chemical binding]; other site 1114958000136 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1114958000137 GIY-YIG motif/motif A; other site 1114958000138 putative active site [active] 1114958000139 putative metal binding site [ion binding]; other site 1114958000140 Predicted methyltransferases [General function prediction only]; Region: COG0313 1114958000141 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1114958000142 putative SAM binding site [chemical binding]; other site 1114958000143 putative homodimer interface [polypeptide binding]; other site 1114958000144 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1114958000145 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1114958000146 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1114958000147 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1114958000148 active site 1114958000149 HIGH motif; other site 1114958000150 KMSKS motif; other site 1114958000151 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1114958000152 tRNA binding surface [nucleotide binding]; other site 1114958000153 anticodon binding site; other site 1114958000154 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1114958000155 dimer interface [polypeptide binding]; other site 1114958000156 putative tRNA-binding site [nucleotide binding]; other site 1114958000157 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1114958000158 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1114958000159 active site 1114958000160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1114958000161 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1114958000162 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1114958000163 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1114958000164 G5 domain; Region: G5; pfam07501 1114958000165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1114958000166 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1114958000167 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1114958000168 putative active site [active] 1114958000169 putative metal binding site [ion binding]; other site 1114958000170 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1114958000171 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1114958000172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958000173 S-adenosylmethionine binding site [chemical binding]; other site 1114958000174 YabG peptidase U57; Region: Peptidase_U57; pfam05582 1114958000175 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1114958000176 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1114958000177 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1114958000178 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1114958000179 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1114958000180 pur operon repressor; Provisional; Region: PRK09213 1114958000181 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1114958000182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958000183 active site 1114958000184 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114958000185 homotrimer interaction site [polypeptide binding]; other site 1114958000186 putative active site [active] 1114958000187 regulatory protein SpoVG; Reviewed; Region: PRK13259 1114958000188 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1114958000189 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1114958000190 Substrate binding site; other site 1114958000191 Mg++ binding site; other site 1114958000192 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1114958000193 active site 1114958000194 substrate binding site [chemical binding]; other site 1114958000195 CoA binding site [chemical binding]; other site 1114958000196 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1114958000197 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1114958000198 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958000199 active site 1114958000200 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1114958000201 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1114958000202 5S rRNA interface [nucleotide binding]; other site 1114958000203 CTC domain interface [polypeptide binding]; other site 1114958000204 L16 interface [polypeptide binding]; other site 1114958000205 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1114958000206 putative active site [active] 1114958000207 catalytic residue [active] 1114958000208 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1114958000209 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1114958000210 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1114958000211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958000212 ATP binding site [chemical binding]; other site 1114958000213 putative Mg++ binding site [ion binding]; other site 1114958000214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958000215 nucleotide binding region [chemical binding]; other site 1114958000216 ATP-binding site [chemical binding]; other site 1114958000217 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1114958000218 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1114958000219 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1114958000220 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1114958000221 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1114958000222 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1114958000223 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1114958000224 putative SAM binding site [chemical binding]; other site 1114958000225 putative homodimer interface [polypeptide binding]; other site 1114958000226 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1114958000227 homodimer interface [polypeptide binding]; other site 1114958000228 metal binding site [ion binding]; metal-binding site 1114958000229 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1114958000230 homodimer interface [polypeptide binding]; other site 1114958000231 active site 1114958000232 putative chemical substrate binding site [chemical binding]; other site 1114958000233 metal binding site [ion binding]; metal-binding site 1114958000234 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958000235 RNA binding surface [nucleotide binding]; other site 1114958000236 sporulation protein YabP; Region: spore_yabP; TIGR02892 1114958000237 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 1114958000238 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1114958000239 Septum formation initiator; Region: DivIC; pfam04977 1114958000240 hypothetical protein; Provisional; Region: PRK08582 1114958000241 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1114958000242 RNA binding site [nucleotide binding]; other site 1114958000243 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1114958000244 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1114958000245 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1114958000246 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1114958000247 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1114958000248 metal ion-dependent adhesion site (MIDAS); other site 1114958000249 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1114958000250 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958000251 active site 1114958000252 ATP binding site [chemical binding]; other site 1114958000253 substrate binding site [chemical binding]; other site 1114958000254 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1114958000255 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1114958000256 Ligand Binding Site [chemical binding]; other site 1114958000257 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1114958000258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958000259 active site 1114958000260 FtsH Extracellular; Region: FtsH_ext; pfam06480 1114958000261 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1114958000262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958000263 Walker A motif; other site 1114958000264 ATP binding site [chemical binding]; other site 1114958000265 Walker B motif; other site 1114958000266 arginine finger; other site 1114958000267 Peptidase family M41; Region: Peptidase_M41; pfam01434 1114958000268 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1114958000269 nucleotide binding site [chemical binding]; other site 1114958000270 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1114958000271 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1114958000272 dimerization interface [polypeptide binding]; other site 1114958000273 domain crossover interface; other site 1114958000274 redox-dependent activation switch; other site 1114958000275 SurA N-terminal domain; Region: SurA_N_3; cl07813 1114958000276 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1114958000277 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1114958000278 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1114958000279 dimer interface [polypeptide binding]; other site 1114958000280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958000281 catalytic residue [active] 1114958000282 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1114958000283 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1114958000284 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1114958000285 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1114958000286 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1114958000287 glutamine binding [chemical binding]; other site 1114958000288 catalytic triad [active] 1114958000289 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1114958000290 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1114958000291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958000292 catalytic residue [active] 1114958000293 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1114958000294 dihydropteroate synthase; Region: DHPS; TIGR01496 1114958000295 substrate binding pocket [chemical binding]; other site 1114958000296 dimer interface [polypeptide binding]; other site 1114958000297 inhibitor binding site; inhibition site 1114958000298 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1114958000299 homooctamer interface [polypeptide binding]; other site 1114958000300 active site 1114958000301 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1114958000302 catalytic center binding site [active] 1114958000303 ATP binding site [chemical binding]; other site 1114958000304 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1114958000305 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1114958000306 FMN binding site [chemical binding]; other site 1114958000307 active site 1114958000308 catalytic residues [active] 1114958000309 substrate binding site [chemical binding]; other site 1114958000310 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1114958000311 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1114958000312 dimer interface [polypeptide binding]; other site 1114958000313 putative anticodon binding site; other site 1114958000314 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1114958000315 motif 1; other site 1114958000316 active site 1114958000317 motif 2; other site 1114958000318 motif 3; other site 1114958000319 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1114958000320 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1114958000321 UvrB/uvrC motif; Region: UVR; pfam02151 1114958000322 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1114958000323 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1114958000324 ADP binding site [chemical binding]; other site 1114958000325 phosphagen binding site; other site 1114958000326 substrate specificity loop; other site 1114958000327 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1114958000328 Clp amino terminal domain; Region: Clp_N; pfam02861 1114958000329 Clp amino terminal domain; Region: Clp_N; pfam02861 1114958000330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958000331 Walker A motif; other site 1114958000332 ATP binding site [chemical binding]; other site 1114958000333 Walker B motif; other site 1114958000334 arginine finger; other site 1114958000335 UvrB/uvrC motif; Region: UVR; pfam02151 1114958000336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958000337 Walker A motif; other site 1114958000338 ATP binding site [chemical binding]; other site 1114958000339 Walker B motif; other site 1114958000340 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1114958000341 DNA repair protein RadA; Provisional; Region: PRK11823 1114958000342 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1114958000343 Walker A motif/ATP binding site; other site 1114958000344 ATP binding site [chemical binding]; other site 1114958000345 Walker B motif; other site 1114958000346 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1114958000347 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1114958000348 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1114958000349 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1114958000350 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1114958000351 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1114958000352 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1114958000353 putative active site [active] 1114958000354 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1114958000355 substrate binding site; other site 1114958000356 dimer interface; other site 1114958000357 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1114958000358 homotrimer interaction site [polypeptide binding]; other site 1114958000359 zinc binding site [ion binding]; other site 1114958000360 CDP-binding sites; other site 1114958000361 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1114958000362 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1114958000363 HIGH motif; other site 1114958000364 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1114958000365 active site 1114958000366 KMSKS motif; other site 1114958000367 serine O-acetyltransferase; Region: cysE; TIGR01172 1114958000368 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1114958000369 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1114958000370 trimer interface [polypeptide binding]; other site 1114958000371 active site 1114958000372 substrate binding site [chemical binding]; other site 1114958000373 CoA binding site [chemical binding]; other site 1114958000374 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1114958000375 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1114958000376 active site 1114958000377 HIGH motif; other site 1114958000378 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1114958000379 KMSKS motif; other site 1114958000380 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1114958000381 tRNA binding surface [nucleotide binding]; other site 1114958000382 anticodon binding site; other site 1114958000383 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1114958000384 active site 1114958000385 metal binding site [ion binding]; metal-binding site 1114958000386 dimerization interface [polypeptide binding]; other site 1114958000387 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1114958000388 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1114958000389 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1114958000390 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 1114958000391 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1114958000392 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958000393 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1114958000394 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1114958000395 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1114958000396 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1114958000397 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1114958000398 putative homodimer interface [polypeptide binding]; other site 1114958000399 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1114958000400 heterodimer interface [polypeptide binding]; other site 1114958000401 homodimer interface [polypeptide binding]; other site 1114958000402 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1114958000403 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1114958000404 23S rRNA interface [nucleotide binding]; other site 1114958000405 L7/L12 interface [polypeptide binding]; other site 1114958000406 putative thiostrepton binding site; other site 1114958000407 L25 interface [polypeptide binding]; other site 1114958000408 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1114958000409 mRNA/rRNA interface [nucleotide binding]; other site 1114958000410 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1114958000411 23S rRNA interface [nucleotide binding]; other site 1114958000412 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1114958000413 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1114958000414 core dimer interface [polypeptide binding]; other site 1114958000415 peripheral dimer interface [polypeptide binding]; other site 1114958000416 L10 interface [polypeptide binding]; other site 1114958000417 L11 interface [polypeptide binding]; other site 1114958000418 putative EF-Tu interaction site [polypeptide binding]; other site 1114958000419 putative EF-G interaction site [polypeptide binding]; other site 1114958000420 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1114958000421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958000422 S-adenosylmethionine binding site [chemical binding]; other site 1114958000423 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1114958000424 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1114958000425 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1114958000426 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1114958000427 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 1114958000428 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1114958000429 RPB1 interaction site [polypeptide binding]; other site 1114958000430 RPB10 interaction site [polypeptide binding]; other site 1114958000431 RPB11 interaction site [polypeptide binding]; other site 1114958000432 RPB3 interaction site [polypeptide binding]; other site 1114958000433 RPB12 interaction site [polypeptide binding]; other site 1114958000434 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1114958000435 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1114958000436 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1114958000437 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1114958000438 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1114958000439 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1114958000440 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1114958000441 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1114958000442 G-loop; other site 1114958000443 DNA binding site [nucleotide binding] 1114958000444 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1114958000445 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1114958000446 S17 interaction site [polypeptide binding]; other site 1114958000447 S8 interaction site; other site 1114958000448 16S rRNA interaction site [nucleotide binding]; other site 1114958000449 streptomycin interaction site [chemical binding]; other site 1114958000450 23S rRNA interaction site [nucleotide binding]; other site 1114958000451 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1114958000452 30S ribosomal protein S7; Validated; Region: PRK05302 1114958000453 elongation factor G; Reviewed; Region: PRK00007 1114958000454 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1114958000455 G1 box; other site 1114958000456 putative GEF interaction site [polypeptide binding]; other site 1114958000457 GTP/Mg2+ binding site [chemical binding]; other site 1114958000458 Switch I region; other site 1114958000459 G2 box; other site 1114958000460 G3 box; other site 1114958000461 Switch II region; other site 1114958000462 G4 box; other site 1114958000463 G5 box; other site 1114958000464 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1114958000465 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1114958000466 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1114958000467 elongation factor Tu; Reviewed; Region: PRK00049 1114958000468 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1114958000469 G1 box; other site 1114958000470 GEF interaction site [polypeptide binding]; other site 1114958000471 GTP/Mg2+ binding site [chemical binding]; other site 1114958000472 Switch I region; other site 1114958000473 G2 box; other site 1114958000474 G3 box; other site 1114958000475 Switch II region; other site 1114958000476 G4 box; other site 1114958000477 G5 box; other site 1114958000478 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1114958000479 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1114958000480 Antibiotic Binding Site [chemical binding]; other site 1114958000481 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114958000482 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1114958000483 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1114958000484 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1114958000485 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1114958000486 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1114958000487 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1114958000488 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1114958000489 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1114958000490 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1114958000491 putative translocon binding site; other site 1114958000492 protein-rRNA interface [nucleotide binding]; other site 1114958000493 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1114958000494 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1114958000495 G-X-X-G motif; other site 1114958000496 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1114958000497 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1114958000498 23S rRNA interface [nucleotide binding]; other site 1114958000499 5S rRNA interface [nucleotide binding]; other site 1114958000500 putative antibiotic binding site [chemical binding]; other site 1114958000501 L25 interface [polypeptide binding]; other site 1114958000502 L27 interface [polypeptide binding]; other site 1114958000503 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1114958000504 23S rRNA interface [nucleotide binding]; other site 1114958000505 putative translocon interaction site; other site 1114958000506 signal recognition particle (SRP54) interaction site; other site 1114958000507 L23 interface [polypeptide binding]; other site 1114958000508 trigger factor interaction site; other site 1114958000509 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1114958000510 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1114958000511 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1114958000512 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1114958000513 RNA binding site [nucleotide binding]; other site 1114958000514 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1114958000515 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1114958000516 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1114958000517 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1114958000518 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1114958000519 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1114958000520 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1114958000521 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1114958000522 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1114958000523 5S rRNA interface [nucleotide binding]; other site 1114958000524 L27 interface [polypeptide binding]; other site 1114958000525 23S rRNA interface [nucleotide binding]; other site 1114958000526 L5 interface [polypeptide binding]; other site 1114958000527 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1114958000528 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1114958000529 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1114958000530 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1114958000531 23S rRNA binding site [nucleotide binding]; other site 1114958000532 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1114958000533 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1114958000534 SecY translocase; Region: SecY; pfam00344 1114958000535 adenylate kinase; Reviewed; Region: adk; PRK00279 1114958000536 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1114958000537 AMP-binding site [chemical binding]; other site 1114958000538 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1114958000539 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1114958000540 active site 1114958000541 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1114958000542 rRNA binding site [nucleotide binding]; other site 1114958000543 predicted 30S ribosome binding site; other site 1114958000544 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1114958000545 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1114958000546 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1114958000547 30S ribosomal protein S11; Validated; Region: PRK05309 1114958000548 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1114958000549 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1114958000550 alphaNTD homodimer interface [polypeptide binding]; other site 1114958000551 alphaNTD - beta interaction site [polypeptide binding]; other site 1114958000552 alphaNTD - beta' interaction site [polypeptide binding]; other site 1114958000553 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1114958000554 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1114958000555 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1114958000556 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1114958000557 Walker A/P-loop; other site 1114958000558 ATP binding site [chemical binding]; other site 1114958000559 Q-loop/lid; other site 1114958000560 ABC transporter signature motif; other site 1114958000561 Walker B; other site 1114958000562 D-loop; other site 1114958000563 H-loop/switch region; other site 1114958000564 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1114958000565 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1114958000566 Walker A/P-loop; other site 1114958000567 ATP binding site [chemical binding]; other site 1114958000568 Q-loop/lid; other site 1114958000569 ABC transporter signature motif; other site 1114958000570 Walker B; other site 1114958000571 D-loop; other site 1114958000572 H-loop/switch region; other site 1114958000573 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1114958000574 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1114958000575 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1114958000576 dimerization interface 3.5A [polypeptide binding]; other site 1114958000577 active site 1114958000578 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1114958000579 23S rRNA interface [nucleotide binding]; other site 1114958000580 L3 interface [polypeptide binding]; other site 1114958000581 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1114958000582 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114958000583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958000584 S-adenosylmethionine binding site [chemical binding]; other site 1114958000585 DinB family; Region: DinB; cl17821 1114958000586 DinB superfamily; Region: DinB_2; pfam12867 1114958000587 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1114958000588 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1114958000589 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1114958000590 active site 1114958000591 metal binding site [ion binding]; metal-binding site 1114958000592 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1114958000593 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1114958000594 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1114958000595 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1114958000596 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1114958000597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000598 putative substrate translocation pore; other site 1114958000599 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1114958000600 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958000601 inhibitor-cofactor binding pocket; inhibition site 1114958000602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958000603 catalytic residue [active] 1114958000604 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1114958000605 active site 1114958000606 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114958000607 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114958000608 NAD(P) binding site [chemical binding]; other site 1114958000609 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1114958000610 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1114958000611 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1114958000612 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1114958000613 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1114958000614 Sodium Bile acid symporter family; Region: SBF; cl17470 1114958000615 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1114958000616 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114958000617 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958000618 ABC-ATPase subunit interface; other site 1114958000619 dimer interface [polypeptide binding]; other site 1114958000620 putative PBP binding regions; other site 1114958000621 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114958000622 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958000623 ABC-ATPase subunit interface; other site 1114958000624 dimer interface [polypeptide binding]; other site 1114958000625 putative PBP binding regions; other site 1114958000626 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1114958000627 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114958000628 intersubunit interface [polypeptide binding]; other site 1114958000629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958000630 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114958000631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958000632 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114958000633 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1114958000634 intersubunit interface [polypeptide binding]; other site 1114958000635 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 1114958000636 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1114958000637 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1114958000638 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1114958000639 Beta-lactamase; Region: Beta-lactamase; cl17358 1114958000640 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114958000641 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1114958000642 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114958000643 active site turn [active] 1114958000644 phosphorylation site [posttranslational modification] 1114958000645 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1114958000646 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1114958000647 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1114958000648 putative active site [active] 1114958000649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114958000650 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1114958000651 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1114958000652 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958000653 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958000654 DNA binding residues [nucleotide binding] 1114958000655 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1114958000656 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1114958000657 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1114958000658 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1114958000659 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1114958000660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1114958000661 YbbR-like protein; Region: YbbR; pfam07949 1114958000662 YbbR-like protein; Region: YbbR; pfam07949 1114958000663 YbbR-like protein; Region: YbbR; pfam07949 1114958000664 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1114958000665 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1114958000666 active site 1114958000667 substrate binding site [chemical binding]; other site 1114958000668 metal binding site [ion binding]; metal-binding site 1114958000669 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1114958000670 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1114958000671 glutaminase active site [active] 1114958000672 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1114958000673 dimer interface [polypeptide binding]; other site 1114958000674 active site 1114958000675 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1114958000676 dimer interface [polypeptide binding]; other site 1114958000677 active site 1114958000678 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1114958000679 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114958000680 Walker A/P-loop; other site 1114958000681 ATP binding site [chemical binding]; other site 1114958000682 Q-loop/lid; other site 1114958000683 ABC transporter signature motif; other site 1114958000684 Walker B; other site 1114958000685 D-loop; other site 1114958000686 H-loop/switch region; other site 1114958000687 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1114958000688 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 1114958000689 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958000690 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114958000691 active site 1114958000692 catalytic tetrad [active] 1114958000693 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1114958000694 holin-like protein; Validated; Region: PRK01658 1114958000695 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958000696 MarR family; Region: MarR; pfam01047 1114958000697 putative transport protein YifK; Provisional; Region: PRK10746 1114958000698 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1114958000699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958000700 active site 1114958000701 motif I; other site 1114958000702 motif II; other site 1114958000703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114958000704 Histidine kinase; Region: HisKA_3; pfam07730 1114958000705 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1114958000706 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114958000707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958000708 active site 1114958000709 phosphorylation site [posttranslational modification] 1114958000710 intermolecular recognition site; other site 1114958000711 dimerization interface [polypeptide binding]; other site 1114958000712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958000713 DNA binding residues [nucleotide binding] 1114958000714 dimerization interface [polypeptide binding]; other site 1114958000715 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958000716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958000717 Walker A/P-loop; other site 1114958000718 ATP binding site [chemical binding]; other site 1114958000719 Q-loop/lid; other site 1114958000720 ABC transporter signature motif; other site 1114958000721 Walker B; other site 1114958000722 D-loop; other site 1114958000723 H-loop/switch region; other site 1114958000724 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1114958000725 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1114958000726 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1114958000727 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1114958000728 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114958000729 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1114958000730 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1114958000731 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1114958000732 active site 1114958000733 catalytic site [active] 1114958000734 metal binding site [ion binding]; metal-binding site 1114958000735 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1114958000736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000737 putative substrate translocation pore; other site 1114958000738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000739 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1114958000740 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1114958000741 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1114958000742 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1114958000743 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1114958000744 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1114958000745 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1114958000746 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1114958000747 active site 1114958000748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958000749 non-specific DNA binding site [nucleotide binding]; other site 1114958000750 salt bridge; other site 1114958000751 sequence-specific DNA binding site [nucleotide binding]; other site 1114958000752 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1114958000753 Glycerol_dehydrogenase-like; Region: GlyDH-like; cd08550 1114958000754 active site 1114958000755 NAD binding site [chemical binding]; other site 1114958000756 metal binding site [ion binding]; metal-binding site 1114958000757 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1114958000758 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958000759 ATP-grasp domain; Region: ATP-grasp; pfam02222 1114958000760 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1114958000761 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1114958000762 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1114958000763 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1114958000764 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 1114958000765 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1114958000766 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1114958000767 active site residue [active] 1114958000768 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1114958000769 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114958000770 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1114958000771 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1114958000772 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1114958000773 homodimer interface [polypeptide binding]; other site 1114958000774 substrate-cofactor binding pocket; other site 1114958000775 catalytic residue [active] 1114958000776 S-methylmethionine transporter; Provisional; Region: PRK11387 1114958000777 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1114958000778 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1114958000779 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1114958000780 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1114958000781 glutaminase; Reviewed; Region: PRK12357 1114958000782 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1114958000783 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958000784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958000785 ATP binding site [chemical binding]; other site 1114958000786 Mg2+ binding site [ion binding]; other site 1114958000787 G-X-G motif; other site 1114958000788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958000789 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958000790 active site 1114958000791 phosphorylation site [posttranslational modification] 1114958000792 intermolecular recognition site; other site 1114958000793 dimerization interface [polypeptide binding]; other site 1114958000794 YcbB domain; Region: YcbB; pfam08664 1114958000795 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1114958000796 putative active site [active] 1114958000797 putative substrate binding site [chemical binding]; other site 1114958000798 Phosphotransferase enzyme family; Region: APH; pfam01636 1114958000799 ATP binding site [chemical binding]; other site 1114958000800 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1114958000801 dodecamer interface 1 [polypeptide binding]; other site 1114958000802 dodecamer interface 2 [polypeptide binding]; other site 1114958000803 trimer interface [polypeptide binding]; other site 1114958000804 TRAP binding interface [polypeptide binding]; other site 1114958000805 Zn binding site [ion binding]; other site 1114958000806 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1114958000807 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1114958000808 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1114958000809 dimer interface [polypeptide binding]; other site 1114958000810 FMN binding site [chemical binding]; other site 1114958000811 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1114958000812 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958000813 Zn binding site [ion binding]; other site 1114958000814 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1114958000815 Zn binding site [ion binding]; other site 1114958000816 Predicted membrane protein [Function unknown]; Region: COG2259 1114958000817 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114958000818 catalytic residues [active] 1114958000819 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1114958000820 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1114958000821 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1114958000822 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1114958000823 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1114958000824 putative active site [active] 1114958000825 putative metal binding site [ion binding]; other site 1114958000826 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1114958000827 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1114958000828 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1114958000829 putative substrate binding pocket [chemical binding]; other site 1114958000830 AC domain interface; other site 1114958000831 catalytic triad [active] 1114958000832 AB domain interface; other site 1114958000833 interchain disulfide; other site 1114958000834 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1114958000835 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114958000836 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958000837 catalytic residue [active] 1114958000838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000839 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958000840 putative substrate translocation pore; other site 1114958000841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958000842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958000843 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1114958000844 active site 1114958000845 homotetramer interface [polypeptide binding]; other site 1114958000846 homodimer interface [polypeptide binding]; other site 1114958000847 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1114958000848 Lipase (class 2); Region: Lipase_2; pfam01674 1114958000849 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1114958000850 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1114958000851 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958000852 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114958000853 active site 1114958000854 catalytic tetrad [active] 1114958000855 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1114958000856 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1114958000857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958000858 binding surface 1114958000859 TPR motif; other site 1114958000860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958000861 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958000862 TPR motif; other site 1114958000863 binding surface 1114958000864 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1114958000865 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1114958000866 NAD binding site [chemical binding]; other site 1114958000867 homodimer interface [polypeptide binding]; other site 1114958000868 active site 1114958000869 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1114958000870 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1114958000871 Ca binding site [ion binding]; other site 1114958000872 active site 1114958000873 catalytic site [active] 1114958000874 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 1114958000875 Predicted transcriptional regulators [Transcription]; Region: COG1695 1114958000876 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1114958000877 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1114958000878 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1114958000879 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1114958000880 metal binding site [ion binding]; metal-binding site 1114958000881 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1114958000882 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1114958000883 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1114958000884 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958000885 ABC-ATPase subunit interface; other site 1114958000886 dimer interface [polypeptide binding]; other site 1114958000887 putative PBP binding regions; other site 1114958000888 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1114958000889 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1114958000890 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1114958000891 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1114958000892 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1114958000893 putative metal binding site [ion binding]; other site 1114958000894 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1114958000895 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1114958000896 putative metal binding site [ion binding]; other site 1114958000897 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1114958000898 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1114958000899 putative metal binding site [ion binding]; other site 1114958000900 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1114958000901 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1114958000902 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1114958000903 benzoate transport; Region: 2A0115; TIGR00895 1114958000904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000905 putative substrate translocation pore; other site 1114958000906 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1114958000907 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1114958000908 Walker A/P-loop; other site 1114958000909 ATP binding site [chemical binding]; other site 1114958000910 Q-loop/lid; other site 1114958000911 ABC transporter signature motif; other site 1114958000912 Walker B; other site 1114958000913 D-loop; other site 1114958000914 H-loop/switch region; other site 1114958000915 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1114958000916 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1114958000917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958000918 dimer interface [polypeptide binding]; other site 1114958000919 conserved gate region; other site 1114958000920 putative PBP binding loops; other site 1114958000921 ABC-ATPase subunit interface; other site 1114958000922 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1114958000923 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114958000924 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114958000925 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1114958000926 amidohydrolase; Region: amidohydrolases; TIGR01891 1114958000927 metal binding site [ion binding]; metal-binding site 1114958000928 putative dimer interface [polypeptide binding]; other site 1114958000929 Predicted membrane protein [Function unknown]; Region: COG1288 1114958000930 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1114958000931 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 1114958000932 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1114958000933 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1114958000934 active site 1114958000935 Ca binding site [ion binding]; other site 1114958000936 catalytic site [active] 1114958000937 Aamy_C domain; Region: Aamy_C; smart00632 1114958000938 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1114958000939 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1114958000940 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114958000941 NAD binding site [chemical binding]; other site 1114958000942 dimer interface [polypeptide binding]; other site 1114958000943 substrate binding site [chemical binding]; other site 1114958000944 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1114958000945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000946 putative substrate translocation pore; other site 1114958000947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000948 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958000949 MarR family; Region: MarR; pfam01047 1114958000950 LysE type translocator; Region: LysE; pfam01810 1114958000951 Uncharacterized conserved protein [Function unknown]; Region: COG3403 1114958000952 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114958000953 Spore germination protein; Region: Spore_permease; cl17796 1114958000954 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1114958000955 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1114958000956 NAD+ synthetase; Region: nadE; TIGR00552 1114958000957 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1114958000958 homodimer interface [polypeptide binding]; other site 1114958000959 NAD binding pocket [chemical binding]; other site 1114958000960 ATP binding pocket [chemical binding]; other site 1114958000961 Mg binding site [ion binding]; other site 1114958000962 active-site loop [active] 1114958000963 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 1114958000964 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1114958000965 AAA domain; Region: AAA_18; pfam13238 1114958000966 active site 1114958000967 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114958000968 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114958000969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958000970 D-galactonate transporter; Region: 2A0114; TIGR00893 1114958000971 putative substrate translocation pore; other site 1114958000972 shikimate kinase; Reviewed; Region: aroK; PRK00131 1114958000973 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1114958000974 ADP binding site [chemical binding]; other site 1114958000975 magnesium binding site [ion binding]; other site 1114958000976 putative shikimate binding site; other site 1114958000977 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1114958000978 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1114958000979 Proline dehydrogenase; Region: Pro_dh; pfam01619 1114958000980 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1114958000981 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1114958000982 Glutamate binding site [chemical binding]; other site 1114958000983 homodimer interface [polypeptide binding]; other site 1114958000984 NAD binding site [chemical binding]; other site 1114958000985 catalytic residues [active] 1114958000986 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1114958000987 Na binding site [ion binding]; other site 1114958000988 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1114958000989 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1114958000990 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1114958000991 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114958000992 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958000993 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 1114958000994 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1114958000995 active site 1114958000996 SAM binding site [chemical binding]; other site 1114958000997 homodimer interface [polypeptide binding]; other site 1114958000998 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1114958000999 [2Fe-2S] cluster binding site [ion binding]; other site 1114958001000 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1114958001001 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958001002 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1114958001003 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1114958001004 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114958001005 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1114958001006 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1114958001007 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1114958001008 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1114958001009 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114958001010 NAD binding site [chemical binding]; other site 1114958001011 catalytic Zn binding site [ion binding]; other site 1114958001012 structural Zn binding site [ion binding]; other site 1114958001013 RDD family; Region: RDD; pfam06271 1114958001014 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1114958001015 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1114958001016 Competence protein J (ComJ); Region: ComJ; pfam11033 1114958001017 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1114958001018 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114958001019 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1114958001020 tetramer interface [polypeptide binding]; other site 1114958001021 active site 1114958001022 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1114958001023 active site 1114958001024 dimer interface [polypeptide binding]; other site 1114958001025 magnesium binding site [ion binding]; other site 1114958001026 Predicted transcriptional regulators [Transcription]; Region: COG1733 1114958001027 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1114958001028 Condensation domain; Region: Condensation; pfam00668 1114958001029 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958001030 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958001031 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958001032 acyl-activating enzyme (AAE) consensus motif; other site 1114958001033 AMP binding site [chemical binding]; other site 1114958001034 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958001035 Condensation domain; Region: Condensation; pfam00668 1114958001036 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958001037 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958001038 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1114958001039 acyl-activating enzyme (AAE) consensus motif; other site 1114958001040 AMP binding site [chemical binding]; other site 1114958001041 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958001042 Condensation domain; Region: Condensation; pfam00668 1114958001043 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958001044 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958001045 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958001046 acyl-activating enzyme (AAE) consensus motif; other site 1114958001047 AMP binding site [chemical binding]; other site 1114958001048 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958001049 Condensation domain; Region: Condensation; pfam00668 1114958001050 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958001051 Condensation domain; Region: Condensation; pfam00668 1114958001052 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958001053 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1114958001054 acyl-activating enzyme (AAE) consensus motif; other site 1114958001055 AMP binding site [chemical binding]; other site 1114958001056 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958001057 Condensation domain; Region: Condensation; pfam00668 1114958001058 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958001059 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958001060 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958001061 acyl-activating enzyme (AAE) consensus motif; other site 1114958001062 AMP binding site [chemical binding]; other site 1114958001063 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958001064 Condensation domain; Region: Condensation; pfam00668 1114958001065 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958001066 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958001067 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958001068 acyl-activating enzyme (AAE) consensus motif; other site 1114958001069 AMP binding site [chemical binding]; other site 1114958001070 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958001071 Condensation domain; Region: Condensation; pfam00668 1114958001072 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958001073 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958001074 Condensation domain; Region: Condensation; pfam00668 1114958001075 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958001076 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1114958001077 acyl-activating enzyme (AAE) consensus motif; other site 1114958001078 AMP binding site [chemical binding]; other site 1114958001079 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958001080 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1114958001081 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1114958001082 PGAP1-like protein; Region: PGAP1; pfam07819 1114958001083 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1114958001084 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958001085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958001086 homodimer interface [polypeptide binding]; other site 1114958001087 catalytic residue [active] 1114958001088 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1114958001089 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 1114958001090 Predicted membrane protein [Function unknown]; Region: COG2364 1114958001091 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958001092 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114958001093 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114958001094 Walker A/P-loop; other site 1114958001095 ATP binding site [chemical binding]; other site 1114958001096 Q-loop/lid; other site 1114958001097 ABC transporter signature motif; other site 1114958001098 Walker B; other site 1114958001099 D-loop; other site 1114958001100 H-loop/switch region; other site 1114958001101 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114958001102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958001103 dimer interface [polypeptide binding]; other site 1114958001104 conserved gate region; other site 1114958001105 putative PBP binding loops; other site 1114958001106 ABC-ATPase subunit interface; other site 1114958001107 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1114958001108 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114958001109 substrate binding pocket [chemical binding]; other site 1114958001110 membrane-bound complex binding site; other site 1114958001111 hinge residues; other site 1114958001112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958001113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958001114 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958001115 dimerization interface [polypeptide binding]; other site 1114958001116 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1114958001117 Flavoprotein; Region: Flavoprotein; pfam02441 1114958001118 UbiD family decarboxylase; Region: TIGR00148 1114958001119 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1114958001120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001121 putative substrate translocation pore; other site 1114958001122 POT family; Region: PTR2; pfam00854 1114958001123 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1114958001124 Right handed beta helix region; Region: Beta_helix; pfam13229 1114958001125 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1114958001126 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1114958001127 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1114958001128 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1114958001129 Spore germination protein; Region: Spore_permease; pfam03845 1114958001130 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1114958001131 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1114958001132 active site 1114958001133 non-prolyl cis peptide bond; other site 1114958001134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958001135 Coenzyme A binding pocket [chemical binding]; other site 1114958001136 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114958001137 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114958001138 substrate binding pocket [chemical binding]; other site 1114958001139 membrane-bound complex binding site; other site 1114958001140 hinge residues; other site 1114958001141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958001142 dimer interface [polypeptide binding]; other site 1114958001143 conserved gate region; other site 1114958001144 putative PBP binding loops; other site 1114958001145 ABC-ATPase subunit interface; other site 1114958001146 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114958001147 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114958001148 Walker A/P-loop; other site 1114958001149 ATP binding site [chemical binding]; other site 1114958001150 Q-loop/lid; other site 1114958001151 ABC transporter signature motif; other site 1114958001152 Walker B; other site 1114958001153 D-loop; other site 1114958001154 H-loop/switch region; other site 1114958001155 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1114958001156 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1114958001157 metal binding site [ion binding]; metal-binding site 1114958001158 dimer interface [polypeptide binding]; other site 1114958001159 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1114958001160 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114958001161 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114958001162 Walker A/P-loop; other site 1114958001163 ATP binding site [chemical binding]; other site 1114958001164 Q-loop/lid; other site 1114958001165 ABC transporter signature motif; other site 1114958001166 Walker B; other site 1114958001167 D-loop; other site 1114958001168 H-loop/switch region; other site 1114958001169 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114958001170 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1114958001171 FtsX-like permease family; Region: FtsX; pfam02687 1114958001172 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958001173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958001174 active site 1114958001175 phosphorylation site [posttranslational modification] 1114958001176 intermolecular recognition site; other site 1114958001177 dimerization interface [polypeptide binding]; other site 1114958001178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958001179 DNA binding site [nucleotide binding] 1114958001180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958001181 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958001182 dimerization interface [polypeptide binding]; other site 1114958001183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958001184 dimer interface [polypeptide binding]; other site 1114958001185 phosphorylation site [posttranslational modification] 1114958001186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958001187 ATP binding site [chemical binding]; other site 1114958001188 Mg2+ binding site [ion binding]; other site 1114958001189 G-X-G motif; other site 1114958001190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958001191 binding surface 1114958001192 TPR motif; other site 1114958001193 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958001194 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958001195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958001196 TPR motif; other site 1114958001197 binding surface 1114958001198 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958001199 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1114958001200 aspartate kinase; Reviewed; Region: PRK09034 1114958001201 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1114958001202 putative catalytic residues [active] 1114958001203 putative nucleotide binding site [chemical binding]; other site 1114958001204 putative aspartate binding site [chemical binding]; other site 1114958001205 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1114958001206 allosteric regulatory residue; other site 1114958001207 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1114958001208 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114958001209 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958001210 ABC-ATPase subunit interface; other site 1114958001211 dimer interface [polypeptide binding]; other site 1114958001212 putative PBP binding regions; other site 1114958001213 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958001214 ABC-ATPase subunit interface; other site 1114958001215 dimer interface [polypeptide binding]; other site 1114958001216 putative PBP binding regions; other site 1114958001217 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1114958001218 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114958001219 Walker A/P-loop; other site 1114958001220 ATP binding site [chemical binding]; other site 1114958001221 Q-loop/lid; other site 1114958001222 ABC transporter signature motif; other site 1114958001223 Walker B; other site 1114958001224 D-loop; other site 1114958001225 H-loop/switch region; other site 1114958001226 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1114958001227 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1114958001228 putative ligand binding residues [chemical binding]; other site 1114958001229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001230 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958001231 putative substrate translocation pore; other site 1114958001232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958001234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958001235 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1114958001236 dimer interface [polypeptide binding]; other site 1114958001237 FMN binding site [chemical binding]; other site 1114958001238 NADPH bind site [chemical binding]; other site 1114958001239 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1114958001240 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958001241 dimerization interface [polypeptide binding]; other site 1114958001242 putative DNA binding site [nucleotide binding]; other site 1114958001243 putative Zn2+ binding site [ion binding]; other site 1114958001244 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114958001245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958001246 DNA-binding site [nucleotide binding]; DNA binding site 1114958001247 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958001248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958001249 homodimer interface [polypeptide binding]; other site 1114958001250 catalytic residue [active] 1114958001251 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1114958001252 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958001253 inhibitor-cofactor binding pocket; inhibition site 1114958001254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958001255 catalytic residue [active] 1114958001256 succinic semialdehyde dehydrogenase; Region: PLN02278 1114958001257 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1114958001258 tetramerization interface [polypeptide binding]; other site 1114958001259 NAD(P) binding site [chemical binding]; other site 1114958001260 catalytic residues [active] 1114958001261 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1114958001262 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1114958001263 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1114958001264 NAD binding site [chemical binding]; other site 1114958001265 homodimer interface [polypeptide binding]; other site 1114958001266 active site 1114958001267 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1114958001268 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1114958001269 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1114958001270 YtkA-like; Region: YtkA; pfam13115 1114958001271 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114958001272 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1114958001273 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1114958001274 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1114958001275 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1114958001276 active site 1114958001277 P-loop; other site 1114958001278 phosphorylation site [posttranslational modification] 1114958001279 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114958001280 active site 1114958001281 phosphorylation site [posttranslational modification] 1114958001282 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1114958001283 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1114958001284 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1114958001285 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1114958001286 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1114958001287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958001288 active site 1114958001289 motif I; other site 1114958001290 motif II; other site 1114958001291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958001292 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1114958001293 putative active site [active] 1114958001294 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1114958001295 hypothetical protein; Provisional; Region: PRK05463 1114958001296 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1114958001297 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1114958001298 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1114958001299 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1114958001300 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1114958001301 Bacterial transcriptional regulator; Region: IclR; pfam01614 1114958001302 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1114958001303 active site 1114958001304 catalytic triad [active] 1114958001305 oxyanion hole [active] 1114958001306 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1114958001307 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1114958001308 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1114958001309 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1114958001310 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114958001311 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1114958001312 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958001313 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114958001314 active site 1114958001315 catalytic tetrad [active] 1114958001316 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1114958001317 HTH domain; Region: HTH_11; pfam08279 1114958001318 Mga helix-turn-helix domain; Region: Mga; pfam05043 1114958001319 PRD domain; Region: PRD; pfam00874 1114958001320 PRD domain; Region: PRD; pfam00874 1114958001321 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1114958001322 active site 1114958001323 P-loop; other site 1114958001324 phosphorylation site [posttranslational modification] 1114958001325 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1114958001326 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1114958001327 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1114958001328 acyl-activating enzyme (AAE) consensus motif; other site 1114958001329 putative AMP binding site [chemical binding]; other site 1114958001330 putative active site [active] 1114958001331 putative CoA binding site [chemical binding]; other site 1114958001332 short chain dehydrogenase; Provisional; Region: PRK06701 1114958001333 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1114958001334 NAD binding site [chemical binding]; other site 1114958001335 metal binding site [ion binding]; metal-binding site 1114958001336 active site 1114958001337 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1114958001338 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114958001339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114958001340 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1114958001341 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1114958001342 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1114958001343 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1114958001344 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1114958001345 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1114958001346 putative DNA binding site [nucleotide binding]; other site 1114958001347 putative Zn2+ binding site [ion binding]; other site 1114958001348 AsnC family; Region: AsnC_trans_reg; pfam01037 1114958001349 DNA topoisomerase III; Provisional; Region: PRK07726 1114958001350 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1114958001351 active site 1114958001352 putative interdomain interaction site [polypeptide binding]; other site 1114958001353 putative metal-binding site [ion binding]; other site 1114958001354 putative nucleotide binding site [chemical binding]; other site 1114958001355 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1114958001356 domain I; other site 1114958001357 DNA binding groove [nucleotide binding] 1114958001358 phosphate binding site [ion binding]; other site 1114958001359 domain II; other site 1114958001360 domain III; other site 1114958001361 nucleotide binding site [chemical binding]; other site 1114958001362 catalytic site [active] 1114958001363 domain IV; other site 1114958001364 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1114958001365 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1114958001366 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1114958001367 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114958001368 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114958001369 metal binding site [ion binding]; metal-binding site 1114958001370 active site 1114958001371 I-site; other site 1114958001372 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1114958001373 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1114958001374 NodB motif; other site 1114958001375 putative active site [active] 1114958001376 putative catalytic site [active] 1114958001377 putative Zn binding site [ion binding]; other site 1114958001378 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1114958001379 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1114958001380 DXD motif; other site 1114958001381 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1114958001382 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1114958001383 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1114958001384 nudix motif; other site 1114958001385 pyruvate oxidase; Provisional; Region: PRK08611 1114958001386 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1114958001387 PYR/PP interface [polypeptide binding]; other site 1114958001388 dimer interface [polypeptide binding]; other site 1114958001389 tetramer interface [polypeptide binding]; other site 1114958001390 TPP binding site [chemical binding]; other site 1114958001391 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1114958001392 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1114958001393 TPP-binding site [chemical binding]; other site 1114958001394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958001395 Coenzyme A binding pocket [chemical binding]; other site 1114958001396 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1114958001397 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1114958001398 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1114958001399 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1114958001400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958001401 binding surface 1114958001402 TPR motif; other site 1114958001403 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958001404 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958001405 manganese transport protein MntH; Reviewed; Region: PRK00701 1114958001406 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1114958001407 Bacterial SH3 domain; Region: SH3_3; cl17532 1114958001408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1114958001409 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1114958001410 EcsC protein family; Region: EcsC; pfam12787 1114958001411 General stress protein [General function prediction only]; Region: GsiB; COG3729 1114958001412 General stress protein [General function prediction only]; Region: GsiB; COG3729 1114958001413 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1114958001414 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1114958001415 dimanganese center [ion binding]; other site 1114958001416 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1114958001417 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1114958001418 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1114958001419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958001420 putative active site [active] 1114958001421 heme pocket [chemical binding]; other site 1114958001422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958001423 ATP binding site [chemical binding]; other site 1114958001424 Mg2+ binding site [ion binding]; other site 1114958001425 G-X-G motif; other site 1114958001426 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1114958001427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958001428 active site 1114958001429 phosphorylation site [posttranslational modification] 1114958001430 intermolecular recognition site; other site 1114958001431 dimerization interface [polypeptide binding]; other site 1114958001432 HTH domain; Region: HTH_11; pfam08279 1114958001433 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1114958001434 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114958001435 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114958001436 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114958001437 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958001438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958001439 Walker A/P-loop; other site 1114958001440 ATP binding site [chemical binding]; other site 1114958001441 Q-loop/lid; other site 1114958001442 ABC transporter signature motif; other site 1114958001443 Walker B; other site 1114958001444 D-loop; other site 1114958001445 H-loop/switch region; other site 1114958001446 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1114958001447 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1114958001448 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114958001449 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114958001450 active site 1114958001451 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1114958001452 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1114958001453 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1114958001454 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1114958001455 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114958001456 catalytic residues [active] 1114958001457 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1114958001458 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1114958001459 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1114958001460 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1114958001461 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114958001462 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114958001463 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114958001464 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1114958001465 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114958001466 ATP binding site [chemical binding]; other site 1114958001467 Mg++ binding site [ion binding]; other site 1114958001468 motif III; other site 1114958001469 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958001470 nucleotide binding region [chemical binding]; other site 1114958001471 ATP-binding site [chemical binding]; other site 1114958001472 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1114958001473 Predicted membrane protein [Function unknown]; Region: COG3428 1114958001474 Bacterial PH domain; Region: DUF304; pfam03703 1114958001475 Bacterial PH domain; Region: DUF304; pfam03703 1114958001476 Bacterial PH domain; Region: DUF304; pfam03703 1114958001477 Rhomboid family; Region: Rhomboid; pfam01694 1114958001478 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1114958001479 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1114958001480 alanine racemase; Region: alr; TIGR00492 1114958001481 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1114958001482 active site 1114958001483 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114958001484 dimer interface [polypeptide binding]; other site 1114958001485 substrate binding site [chemical binding]; other site 1114958001486 catalytic residues [active] 1114958001487 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1114958001488 ribbon-helix-helix domain containing protein; Region: PHA00617 1114958001489 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 1114958001490 Rsbr N terminal; Region: Rsbr_N; pfam08678 1114958001491 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1114958001492 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1114958001493 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1114958001494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958001495 ATP binding site [chemical binding]; other site 1114958001496 Mg2+ binding site [ion binding]; other site 1114958001497 G-X-G motif; other site 1114958001498 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1114958001499 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1114958001500 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1114958001501 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1114958001502 anti sigma factor interaction site; other site 1114958001503 regulatory phosphorylation site [posttranslational modification]; other site 1114958001504 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1114958001505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958001506 ATP binding site [chemical binding]; other site 1114958001507 Mg2+ binding site [ion binding]; other site 1114958001508 G-X-G motif; other site 1114958001509 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1114958001510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958001511 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114958001512 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958001513 DNA binding residues [nucleotide binding] 1114958001514 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1114958001515 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1114958001516 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1114958001517 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1114958001518 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1114958001519 RNA binding site [nucleotide binding]; other site 1114958001520 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1114958001521 hypothetical protein; Provisional; Region: PRK04351 1114958001522 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1114958001523 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114958001524 proline/glycine betaine transporter; Provisional; Region: PRK10642 1114958001525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001526 putative substrate translocation pore; other site 1114958001527 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1114958001528 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1114958001529 substrate binding pocket [chemical binding]; other site 1114958001530 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114958001531 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1114958001532 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1114958001533 MarR family; Region: MarR; pfam01047 1114958001534 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1114958001535 putative active site [active] 1114958001536 putative catalytic site [active] 1114958001537 Predicted transcriptional regulator [Transcription]; Region: COG1959 1114958001538 Transcriptional regulator; Region: Rrf2; pfam02082 1114958001539 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1114958001540 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1114958001541 NAD binding site [chemical binding]; other site 1114958001542 substrate binding site [chemical binding]; other site 1114958001543 putative active site [active] 1114958001544 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1114958001545 DNA-binding site [nucleotide binding]; DNA binding site 1114958001546 RNA-binding motif; other site 1114958001547 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1114958001548 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1114958001549 putative homodimer interface [polypeptide binding]; other site 1114958001550 putative homotetramer interface [polypeptide binding]; other site 1114958001551 putative metal binding site [ion binding]; other site 1114958001552 putative homodimer-homodimer interface [polypeptide binding]; other site 1114958001553 putative allosteric switch controlling residues; other site 1114958001554 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1114958001555 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1114958001556 CPxP motif; other site 1114958001557 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1114958001558 active site residue [active] 1114958001559 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1114958001560 active site residue [active] 1114958001561 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114958001562 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1114958001563 CPxP motif; other site 1114958001564 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114958001565 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1114958001566 aspartate racemase; Region: asp_race; TIGR00035 1114958001567 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1114958001568 Predicted transcriptional regulators [Transcription]; Region: COG1695 1114958001569 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1114958001570 Patatin [General function prediction only]; Region: COG3621 1114958001571 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 1114958001572 active site 1114958001573 nucleophile elbow; other site 1114958001574 DinB superfamily; Region: DinB_2; pfam12867 1114958001575 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1114958001576 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1114958001577 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958001578 catalytic residue [active] 1114958001579 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114958001580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958001581 DNA-binding site [nucleotide binding]; DNA binding site 1114958001582 FCD domain; Region: FCD; pfam07729 1114958001583 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1114958001584 homotrimer interaction site [polypeptide binding]; other site 1114958001585 putative active site [active] 1114958001586 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 1114958001587 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1114958001588 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1114958001589 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1114958001590 metal binding site [ion binding]; metal-binding site 1114958001591 putative dimer interface [polypeptide binding]; other site 1114958001592 Cupin domain; Region: Cupin_2; pfam07883 1114958001593 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114958001594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958001595 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1114958001596 allantoate amidohydrolase; Reviewed; Region: PRK12890 1114958001597 active site 1114958001598 metal binding site [ion binding]; metal-binding site 1114958001599 dimer interface [polypeptide binding]; other site 1114958001600 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114958001601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958001602 DNA-binding site [nucleotide binding]; DNA binding site 1114958001603 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958001604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958001605 homodimer interface [polypeptide binding]; other site 1114958001606 catalytic residue [active] 1114958001607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001608 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958001609 putative substrate translocation pore; other site 1114958001610 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1114958001611 nudix motif; other site 1114958001612 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114958001613 FAD binding domain; Region: FAD_binding_4; pfam01565 1114958001614 Berberine and berberine like; Region: BBE; pfam08031 1114958001615 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1114958001616 active site 1114958001617 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1114958001618 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1114958001619 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1114958001620 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1114958001621 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 1114958001622 N-acetylneuraminate lyase; Region: nanA; TIGR00683 1114958001623 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1114958001624 inhibitor site; inhibition site 1114958001625 active site 1114958001626 dimer interface [polypeptide binding]; other site 1114958001627 catalytic residue [active] 1114958001628 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 1114958001629 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958001630 FeS/SAM binding site; other site 1114958001631 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1114958001632 Sodium Bile acid symporter family; Region: SBF; cl17470 1114958001633 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1114958001634 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1114958001635 putative NAD(P) binding site [chemical binding]; other site 1114958001636 putative substrate binding site [chemical binding]; other site 1114958001637 catalytic Zn binding site [ion binding]; other site 1114958001638 structural Zn binding site [ion binding]; other site 1114958001639 dimer interface [polypeptide binding]; other site 1114958001640 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1114958001641 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1114958001642 DNA binding residues [nucleotide binding] 1114958001643 putative dimer interface [polypeptide binding]; other site 1114958001644 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 1114958001645 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114958001646 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958001647 DNA-binding site [nucleotide binding]; DNA binding site 1114958001648 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958001649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958001650 homodimer interface [polypeptide binding]; other site 1114958001651 catalytic residue [active] 1114958001652 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1114958001653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001654 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958001655 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958001656 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1114958001657 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1114958001658 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114958001659 NAD binding site [chemical binding]; other site 1114958001660 catalytic Zn binding site [ion binding]; other site 1114958001661 structural Zn binding site [ion binding]; other site 1114958001662 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1114958001663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114958001664 Histidine kinase; Region: HisKA_3; pfam07730 1114958001665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958001666 ATP binding site [chemical binding]; other site 1114958001667 Mg2+ binding site [ion binding]; other site 1114958001668 G-X-G motif; other site 1114958001669 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114958001670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958001671 active site 1114958001672 phosphorylation site [posttranslational modification] 1114958001673 intermolecular recognition site; other site 1114958001674 dimerization interface [polypeptide binding]; other site 1114958001675 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958001676 DNA binding residues [nucleotide binding] 1114958001677 dimerization interface [polypeptide binding]; other site 1114958001678 MMPL family; Region: MMPL; pfam03176 1114958001679 methane monooxygenase/ammonia monooxygenase, subunit A; Region: CH4_NH3mon_ox_A; TIGR03080 1114958001680 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1114958001681 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1114958001682 catalytic triad [active] 1114958001683 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114958001684 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114958001685 ABC transporter; Region: ABC_tran_2; pfam12848 1114958001686 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114958001687 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114958001688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958001689 Coenzyme A binding pocket [chemical binding]; other site 1114958001690 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958001691 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958001692 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958001693 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1114958001694 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1114958001695 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1114958001696 dimer interface [polypeptide binding]; other site 1114958001697 active site 1114958001698 metal binding site [ion binding]; metal-binding site 1114958001699 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1114958001700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001701 putative substrate translocation pore; other site 1114958001702 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1114958001703 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114958001704 dimer interface [polypeptide binding]; other site 1114958001705 active site 1114958001706 Helix-turn-helix domain; Region: HTH_31; pfam13560 1114958001707 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114958001708 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1114958001709 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1114958001710 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114958001711 DNA binding residues [nucleotide binding] 1114958001712 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1114958001713 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1114958001714 EamA-like transporter family; Region: EamA; pfam00892 1114958001715 EamA-like transporter family; Region: EamA; pfam00892 1114958001716 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1114958001717 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1114958001718 nudix motif; other site 1114958001719 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114958001720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958001721 S-adenosylmethionine binding site [chemical binding]; other site 1114958001722 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1114958001723 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1114958001724 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1114958001725 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958001726 DNA-binding site [nucleotide binding]; DNA binding site 1114958001727 FCD domain; Region: FCD; pfam07729 1114958001728 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1114958001729 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1114958001730 active site 1114958001731 TDP-binding site; other site 1114958001732 acceptor substrate-binding pocket; other site 1114958001733 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114958001734 Beta-lactamase; Region: Beta-lactamase; pfam00144 1114958001735 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1114958001736 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1114958001737 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1114958001738 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114958001739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001740 putative substrate translocation pore; other site 1114958001741 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1114958001742 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958001743 DNA-binding site [nucleotide binding]; DNA binding site 1114958001744 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1114958001745 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114958001746 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958001747 DNA-binding site [nucleotide binding]; DNA binding site 1114958001748 FCD domain; Region: FCD; pfam07729 1114958001749 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1114958001750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001751 putative substrate translocation pore; other site 1114958001752 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1114958001753 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1114958001754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958001755 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958001756 amino acid transporter; Region: 2A0306; TIGR00909 1114958001757 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1114958001758 dimanganese center [ion binding]; other site 1114958001759 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1114958001760 putative hydrophobic ligand binding site [chemical binding]; other site 1114958001761 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1114958001762 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1114958001763 putative NADP binding site [chemical binding]; other site 1114958001764 putative dimer interface [polypeptide binding]; other site 1114958001765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001766 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1114958001767 putative substrate translocation pore; other site 1114958001768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001769 thiamine monophosphate kinase; Provisional; Region: PRK05731 1114958001770 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1114958001771 ATP binding site [chemical binding]; other site 1114958001772 dimerization interface [polypeptide binding]; other site 1114958001773 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1114958001774 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1114958001775 Glycoprotease family; Region: Peptidase_M22; pfam00814 1114958001776 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1114958001777 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958001778 Coenzyme A binding pocket [chemical binding]; other site 1114958001779 UGMP family protein; Validated; Region: PRK09604 1114958001780 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1114958001781 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1114958001782 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114958001783 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114958001784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958001785 Walker A/P-loop; other site 1114958001786 ATP binding site [chemical binding]; other site 1114958001787 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114958001788 ABC transporter signature motif; other site 1114958001789 ABC transporter; Region: ABC_tran_2; pfam12848 1114958001790 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114958001791 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1114958001792 trimer interface [polypeptide binding]; other site 1114958001793 dimer interface [polypeptide binding]; other site 1114958001794 putative active site [active] 1114958001795 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1114958001796 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1114958001797 CoA binding domain; Region: CoA_binding; pfam02629 1114958001798 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1114958001799 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1114958001800 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1114958001801 CAAX protease self-immunity; Region: Abi; pfam02517 1114958001802 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1114958001803 oligomerisation interface [polypeptide binding]; other site 1114958001804 mobile loop; other site 1114958001805 roof hairpin; other site 1114958001806 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1114958001807 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1114958001808 ring oligomerisation interface [polypeptide binding]; other site 1114958001809 ATP/Mg binding site [chemical binding]; other site 1114958001810 stacking interactions; other site 1114958001811 hinge regions; other site 1114958001812 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1114958001813 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1114958001814 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1114958001815 active site 1114958001816 DNA binding site [nucleotide binding] 1114958001817 Int/Topo IB signature motif; other site 1114958001818 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1114958001819 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114958001820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958001821 non-specific DNA binding site [nucleotide binding]; other site 1114958001822 salt bridge; other site 1114958001823 sequence-specific DNA binding site [nucleotide binding]; other site 1114958001824 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 1114958001825 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 1114958001826 Helix-turn-helix; Region: HTH_3; pfam01381 1114958001827 non-specific DNA binding site [nucleotide binding]; other site 1114958001828 salt bridge; other site 1114958001829 sequence-specific DNA binding site [nucleotide binding]; other site 1114958001830 Hypothetical protein Yqai; Region: Yqai; pfam09466 1114958001831 Phage-related protein, predicted endonuclease [DNA replication, recombination, and repair]; Region: COG5377 1114958001832 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 1114958001833 Helix-turn-helix domain; Region: HTH_36; pfam13730 1114958001834 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1114958001835 hypothetical protein; Provisional; Region: PRK06921 1114958001836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958001837 Walker A motif; other site 1114958001838 ATP binding site [chemical binding]; other site 1114958001839 Walker B motif; other site 1114958001840 arginine finger; other site 1114958001841 YopX protein; Region: YopX; pfam09643 1114958001842 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1114958001843 YopX protein; Region: YopX; cl09859 1114958001844 positive control sigma-like factor; Validated; Region: PRK06930 1114958001845 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958001846 DNA binding residues [nucleotide binding] 1114958001847 Helix-turn-helix domain; Region: HTH_17; pfam12728 1114958001848 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1114958001849 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1114958001850 Phage terminase large subunit; Region: Terminase_3; cl12054 1114958001851 Terminase-like family; Region: Terminase_6; pfam03237 1114958001852 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 1114958001853 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1114958001854 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1114958001855 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 1114958001856 Phage capsid family; Region: Phage_capsid; pfam05065 1114958001857 Head-Tail Connector Protein gp15 of Bacteriophage SPP1 and similar proteins; Region: gp15; cd08055 1114958001858 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1114958001859 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1114958001860 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1114958001861 Phage major tail protein 2; Region: Phage_tail_2; cl11463 1114958001862 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1114958001863 Interdomain contacts; other site 1114958001864 Cytokine receptor motif; other site 1114958001865 Phage protein; Region: DUF3647; pfam12363 1114958001866 type III secretion protein HrpB7; Region: HrpB7; TIGR02559 1114958001867 membrane protein P6; Region: PHA01399 1114958001868 Phage tail protein; Region: Sipho_tail; pfam05709 1114958001869 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1114958001870 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1114958001871 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1114958001872 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114958001873 amidase catalytic site [active] 1114958001874 Zn binding residues [ion binding]; other site 1114958001875 substrate binding site [chemical binding]; other site 1114958001876 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1114958001877 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958001878 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1114958001879 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1114958001880 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1114958001881 metal binding triad [ion binding]; metal-binding site 1114958001882 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 1114958001883 LXG domain of WXG superfamily; Region: LXG; pfam04740 1114958001884 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1114958001885 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1114958001886 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1114958001887 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1114958001888 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1114958001889 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1114958001890 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1114958001891 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1114958001892 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1114958001893 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1114958001894 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1114958001895 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958001896 ATP binding site [chemical binding]; other site 1114958001897 putative Mg++ binding site [ion binding]; other site 1114958001898 silicon transporter; Region: sit; TIGR00811 1114958001899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958001900 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114958001901 Walker A motif; other site 1114958001902 ATP binding site [chemical binding]; other site 1114958001903 Walker B motif; other site 1114958001904 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958001905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958001906 binding surface 1114958001907 TPR motif; other site 1114958001908 TPR repeat; Region: TPR_11; pfam13414 1114958001909 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114958001910 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1114958001911 inhibitor binding site; inhibition site 1114958001912 catalytic Zn binding site [ion binding]; other site 1114958001913 structural Zn binding site [ion binding]; other site 1114958001914 NADP binding site [chemical binding]; other site 1114958001915 tetramer interface [polypeptide binding]; other site 1114958001916 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1114958001917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958001918 putative substrate translocation pore; other site 1114958001919 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114958001920 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1114958001921 putative substrate binding site [chemical binding]; other site 1114958001922 putative ATP binding site [chemical binding]; other site 1114958001923 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1114958001924 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1114958001925 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 1114958001926 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1114958001927 Repair protein; Region: Repair_PSII; pfam04536 1114958001928 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1114958001929 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1114958001930 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1114958001931 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1114958001932 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1114958001933 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1114958001934 catalytic triad [active] 1114958001935 catalytic triad [active] 1114958001936 oxyanion hole [active] 1114958001937 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1114958001938 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1114958001939 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1114958001940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958001941 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958001942 DNA binding residues [nucleotide binding] 1114958001943 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1114958001944 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1114958001945 putative NAD(P) binding site [chemical binding]; other site 1114958001946 catalytic Zn binding site [ion binding]; other site 1114958001947 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1114958001948 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1114958001949 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1114958001950 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1114958001951 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1114958001952 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1114958001953 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1114958001954 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1114958001955 MoxR-like ATPases [General function prediction only]; Region: COG0714 1114958001956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958001957 Walker A motif; other site 1114958001958 ATP binding site [chemical binding]; other site 1114958001959 Walker B motif; other site 1114958001960 arginine finger; other site 1114958001961 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1114958001962 Protein of unknown function DUF58; Region: DUF58; pfam01882 1114958001963 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1114958001964 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1114958001965 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1114958001966 GMP synthase; Reviewed; Region: guaA; PRK00074 1114958001967 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1114958001968 AMP/PPi binding site [chemical binding]; other site 1114958001969 candidate oxyanion hole; other site 1114958001970 catalytic triad [active] 1114958001971 potential glutamine specificity residues [chemical binding]; other site 1114958001972 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1114958001973 ATP Binding subdomain [chemical binding]; other site 1114958001974 Ligand Binding sites [chemical binding]; other site 1114958001975 Dimerization subdomain; other site 1114958001976 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1114958001977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958001978 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958001979 DNA binding residues [nucleotide binding] 1114958001980 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1114958001981 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1114958001982 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1114958001983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1114958001984 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1114958001985 NETI protein; Region: NETI; pfam14044 1114958001986 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1114958001987 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1114958001988 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1114958001989 NAD binding site [chemical binding]; other site 1114958001990 ATP-grasp domain; Region: ATP-grasp; pfam02222 1114958001991 adenylosuccinate lyase; Provisional; Region: PRK07492 1114958001992 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1114958001993 tetramer interface [polypeptide binding]; other site 1114958001994 active site 1114958001995 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1114958001996 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1114958001997 ATP binding site [chemical binding]; other site 1114958001998 active site 1114958001999 substrate binding site [chemical binding]; other site 1114958002000 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1114958002001 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1114958002002 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1114958002003 putative active site [active] 1114958002004 catalytic triad [active] 1114958002005 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1114958002006 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1114958002007 dimerization interface [polypeptide binding]; other site 1114958002008 ATP binding site [chemical binding]; other site 1114958002009 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1114958002010 dimerization interface [polypeptide binding]; other site 1114958002011 ATP binding site [chemical binding]; other site 1114958002012 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1114958002013 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1114958002014 active site 1114958002015 tetramer interface [polypeptide binding]; other site 1114958002016 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958002017 active site 1114958002018 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1114958002019 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1114958002020 dimerization interface [polypeptide binding]; other site 1114958002021 putative ATP binding site [chemical binding]; other site 1114958002022 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1114958002023 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1114958002024 active site 1114958002025 substrate binding site [chemical binding]; other site 1114958002026 cosubstrate binding site; other site 1114958002027 catalytic site [active] 1114958002028 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1114958002029 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1114958002030 purine monophosphate binding site [chemical binding]; other site 1114958002031 dimer interface [polypeptide binding]; other site 1114958002032 putative catalytic residues [active] 1114958002033 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1114958002034 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1114958002035 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1114958002036 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1114958002037 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1114958002038 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1114958002039 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1114958002040 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958002041 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1114958002042 active site 1114958002043 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958002044 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1114958002045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1114958002046 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1114958002047 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1114958002048 active site 1114958002049 FMN binding site [chemical binding]; other site 1114958002050 substrate binding site [chemical binding]; other site 1114958002051 3Fe-4S cluster binding site [ion binding]; other site 1114958002052 PcrB family; Region: PcrB; pfam01884 1114958002053 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1114958002054 substrate binding site [chemical binding]; other site 1114958002055 putative active site [active] 1114958002056 dimer interface [polypeptide binding]; other site 1114958002057 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1114958002058 Part of AAA domain; Region: AAA_19; pfam13245 1114958002059 Family description; Region: UvrD_C_2; pfam13538 1114958002060 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1114958002061 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1114958002062 nucleotide binding pocket [chemical binding]; other site 1114958002063 K-X-D-G motif; other site 1114958002064 catalytic site [active] 1114958002065 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1114958002066 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1114958002067 Helix-hairpin-helix motif; Region: HHH; pfam00633 1114958002068 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1114958002069 Dimer interface [polypeptide binding]; other site 1114958002070 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1114958002071 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1114958002072 putative dimer interface [polypeptide binding]; other site 1114958002073 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1114958002074 putative dimer interface [polypeptide binding]; other site 1114958002075 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1114958002076 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1114958002077 active site 1114958002078 ATP binding site [chemical binding]; other site 1114958002079 substrate binding site [chemical binding]; other site 1114958002080 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1114958002081 MgtC family; Region: MgtC; pfam02308 1114958002082 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1114958002083 Na binding site [ion binding]; other site 1114958002084 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1114958002085 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1114958002086 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1114958002087 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1114958002088 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1114958002089 GatB domain; Region: GatB_Yqey; pfam02637 1114958002090 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958002091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958002092 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1114958002093 Protein export membrane protein; Region: SecD_SecF; cl14618 1114958002094 putative lipid kinase; Reviewed; Region: PRK13337 1114958002095 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1114958002096 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1114958002097 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1114958002098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958002099 S-adenosylmethionine binding site [chemical binding]; other site 1114958002100 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958002101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958002102 Walker A/P-loop; other site 1114958002103 ATP binding site [chemical binding]; other site 1114958002104 Q-loop/lid; other site 1114958002105 ABC transporter signature motif; other site 1114958002106 Walker B; other site 1114958002107 D-loop; other site 1114958002108 H-loop/switch region; other site 1114958002109 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114958002110 Protein of unknown function, DUF600; Region: DUF600; pfam04634 1114958002111 LXG domain of WXG superfamily; Region: LXG; pfam04740 1114958002112 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1114958002113 hypothetical protein; Provisional; Region: PRK12378 1114958002114 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1114958002115 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1114958002116 CotJB protein; Region: CotJB; pfam12652 1114958002117 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1114958002118 dimanganese center [ion binding]; other site 1114958002119 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958002120 Coenzyme A binding pocket [chemical binding]; other site 1114958002121 YesK-like protein; Region: YesK; pfam14150 1114958002122 Predicted membrane protein [Function unknown]; Region: COG2323 1114958002123 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1114958002124 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958002125 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1114958002126 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1114958002127 Uncharacterized small protein [Function unknown]; Region: COG5583 1114958002128 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1114958002129 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1114958002130 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958002131 MarR family; Region: MarR; pfam01047 1114958002132 hypothetical protein; Provisional; Region: PRK06847 1114958002133 hypothetical protein; Provisional; Region: PRK07236 1114958002134 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1114958002135 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1114958002136 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1114958002137 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1114958002138 Cytochrome P450; Region: p450; pfam00067 1114958002139 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1114958002140 Flavodoxin; Region: Flavodoxin_1; pfam00258 1114958002141 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1114958002142 FAD binding pocket [chemical binding]; other site 1114958002143 FAD binding motif [chemical binding]; other site 1114958002144 catalytic residues [active] 1114958002145 NAD binding pocket [chemical binding]; other site 1114958002146 phosphate binding motif [ion binding]; other site 1114958002147 beta-alpha-beta structure motif; other site 1114958002148 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1114958002149 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958002150 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114958002151 Walker A/P-loop; other site 1114958002152 ATP binding site [chemical binding]; other site 1114958002153 Q-loop/lid; other site 1114958002154 ABC transporter signature motif; other site 1114958002155 Walker B; other site 1114958002156 D-loop; other site 1114958002157 H-loop/switch region; other site 1114958002158 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1114958002159 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1114958002160 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1114958002161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958002162 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1114958002163 YcaO-like family; Region: YcaO; pfam02624 1114958002164 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1114958002165 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1114958002166 putative FMN binding site [chemical binding]; other site 1114958002167 NADPH bind site [chemical binding]; other site 1114958002168 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114958002169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958002170 S-adenosylmethionine binding site [chemical binding]; other site 1114958002171 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1114958002172 Sulfatase; Region: Sulfatase; pfam00884 1114958002173 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1114958002174 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1114958002175 substrate binding site; other site 1114958002176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958002177 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114958002178 NAD(P) binding site [chemical binding]; other site 1114958002179 active site 1114958002180 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1114958002181 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1114958002182 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958002183 active site 1114958002184 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1114958002185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002186 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958002187 putative substrate translocation pore; other site 1114958002188 amino acid transporter; Region: 2A0306; TIGR00909 1114958002189 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1114958002190 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1114958002191 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114958002192 NAD(P) binding site [chemical binding]; other site 1114958002193 catalytic residues [active] 1114958002194 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958002195 dimer interface [polypeptide binding]; other site 1114958002196 putative CheW interface [polypeptide binding]; other site 1114958002197 oxidoreductase; Provisional; Region: PRK07985 1114958002198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958002199 NAD(P) binding site [chemical binding]; other site 1114958002200 active site 1114958002201 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1114958002202 putative metal binding site; other site 1114958002203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958002204 binding surface 1114958002205 TPR motif; other site 1114958002206 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114958002207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958002208 Walker A/P-loop; other site 1114958002209 ATP binding site [chemical binding]; other site 1114958002210 Q-loop/lid; other site 1114958002211 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114958002212 ABC transporter signature motif; other site 1114958002213 Walker B; other site 1114958002214 D-loop; other site 1114958002215 ABC transporter; Region: ABC_tran_2; pfam12848 1114958002216 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114958002217 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1114958002218 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1114958002219 DNA binding residues [nucleotide binding] 1114958002220 putative dimer interface [polypeptide binding]; other site 1114958002221 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114958002222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002223 putative substrate translocation pore; other site 1114958002224 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114958002225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958002226 Walker A/P-loop; other site 1114958002227 ATP binding site [chemical binding]; other site 1114958002228 Q-loop/lid; other site 1114958002229 ABC transporter signature motif; other site 1114958002230 Walker B; other site 1114958002231 D-loop; other site 1114958002232 H-loop/switch region; other site 1114958002233 ABC transporter; Region: ABC_tran_2; pfam12848 1114958002234 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114958002235 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114958002236 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1114958002237 ATP binding site [chemical binding]; other site 1114958002238 Mg++ binding site [ion binding]; other site 1114958002239 motif III; other site 1114958002240 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958002241 nucleotide binding region [chemical binding]; other site 1114958002242 ATP-binding site [chemical binding]; other site 1114958002243 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1114958002244 Coenzyme A binding pocket [chemical binding]; other site 1114958002245 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1114958002246 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1114958002247 NAD(P) binding site [chemical binding]; other site 1114958002248 substrate binding site [chemical binding]; other site 1114958002249 dimer interface [polypeptide binding]; other site 1114958002250 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1114958002251 Heat induced stress protein YflT; Region: YflT; pfam11181 1114958002252 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1114958002253 Amb_all domain; Region: Amb_all; smart00656 1114958002254 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1114958002255 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1114958002256 transmembrane helices; other site 1114958002257 BclB C-terminal domain; Region: exospore_TM; TIGR03721 1114958002258 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1114958002259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958002260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958002261 dimer interface [polypeptide binding]; other site 1114958002262 phosphorylation site [posttranslational modification] 1114958002263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958002264 ATP binding site [chemical binding]; other site 1114958002265 Mg2+ binding site [ion binding]; other site 1114958002266 G-X-G motif; other site 1114958002267 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958002268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958002269 active site 1114958002270 phosphorylation site [posttranslational modification] 1114958002271 intermolecular recognition site; other site 1114958002272 dimerization interface [polypeptide binding]; other site 1114958002273 Histidine kinase; Region: His_kinase; pfam06580 1114958002274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958002275 ATP binding site [chemical binding]; other site 1114958002276 Mg2+ binding site [ion binding]; other site 1114958002277 G-X-G motif; other site 1114958002278 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1114958002279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958002280 active site 1114958002281 phosphorylation site [posttranslational modification] 1114958002282 intermolecular recognition site; other site 1114958002283 dimerization interface [polypeptide binding]; other site 1114958002284 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1114958002285 DNA binding site [nucleotide binding] 1114958002286 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1114958002287 Collagen binding domain; Region: Collagen_bind; pfam05737 1114958002288 Collagen binding domain; Region: Collagen_bind; pfam05737 1114958002289 Collagen binding domain; Region: Collagen_bind; pfam05737 1114958002290 Cna protein B-type domain; Region: Cna_B; pfam05738 1114958002291 Cna protein B-type domain; Region: Cna_B; pfam05738 1114958002292 Cna protein B-type domain; Region: Cna_B; pfam05738 1114958002293 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1114958002294 Cna protein B-type domain; Region: Cna_B; pfam05738 1114958002295 Cna protein B-type domain; Region: Cna_B; pfam05738 1114958002296 Cna protein B-type domain; Region: Cna_B; pfam05738 1114958002297 Cna protein B-type domain; Region: Cna_B; pfam05738 1114958002298 Cna protein B-type domain; Region: Cna_B; pfam05738 1114958002299 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1114958002300 active site 1114958002301 catalytic site [active] 1114958002302 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1114958002303 PAS domain; Region: PAS; smart00091 1114958002304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958002305 ATP binding site [chemical binding]; other site 1114958002306 Mg2+ binding site [ion binding]; other site 1114958002307 G-X-G motif; other site 1114958002308 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1114958002309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958002310 active site 1114958002311 phosphorylation site [posttranslational modification] 1114958002312 intermolecular recognition site; other site 1114958002313 dimerization interface [polypeptide binding]; other site 1114958002314 Transcriptional regulator; Region: CitT; pfam12431 1114958002315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1114958002316 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1114958002317 Citrate transporter; Region: CitMHS; pfam03600 1114958002318 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114958002319 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1114958002320 active site 1114958002321 dimer interface [polypeptide binding]; other site 1114958002322 acylphosphatase; Provisional; Region: PRK14420 1114958002323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1114958002324 MOSC domain; Region: MOSC; pfam03473 1114958002325 3-alpha domain; Region: 3-alpha; pfam03475 1114958002326 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1114958002327 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1114958002328 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1114958002329 active site 1114958002330 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1114958002331 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1114958002332 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114958002333 active site turn [active] 1114958002334 phosphorylation site [posttranslational modification] 1114958002335 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1114958002336 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1114958002337 Sulfatase; Region: Sulfatase; pfam00884 1114958002338 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1114958002339 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1114958002340 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1114958002341 putative dimer interface [polypeptide binding]; other site 1114958002342 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1114958002343 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1114958002344 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1114958002345 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114958002346 active site turn [active] 1114958002347 phosphorylation site [posttranslational modification] 1114958002348 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1114958002349 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1114958002350 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1114958002351 Ca binding site [ion binding]; other site 1114958002352 active site 1114958002353 catalytic site [active] 1114958002354 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1114958002355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958002356 DNA-binding site [nucleotide binding]; DNA binding site 1114958002357 UTRA domain; Region: UTRA; pfam07702 1114958002358 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1114958002359 dimer interface [polypeptide binding]; other site 1114958002360 FMN binding site [chemical binding]; other site 1114958002361 YibE/F-like protein; Region: YibE_F; pfam07907 1114958002362 YibE/F-like protein; Region: YibE_F; pfam07907 1114958002363 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1114958002364 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1114958002365 active site 1114958002366 metal binding site [ion binding]; metal-binding site 1114958002367 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1114958002368 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1114958002369 active site 1114958002370 metal binding site [ion binding]; metal-binding site 1114958002371 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1114958002372 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1114958002373 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1114958002374 proposed catalytic triad [active] 1114958002375 conserved cys residue [active] 1114958002376 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958002377 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958002378 DNA binding site [nucleotide binding] 1114958002379 domain linker motif; other site 1114958002380 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1114958002381 putative dimerization interface [polypeptide binding]; other site 1114958002382 putative ligand binding site [chemical binding]; other site 1114958002383 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1114958002384 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1114958002385 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1114958002386 shikimate binding site; other site 1114958002387 NAD(P) binding site [chemical binding]; other site 1114958002388 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1114958002389 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1114958002390 active site 1114958002391 catalytic residue [active] 1114958002392 dimer interface [polypeptide binding]; other site 1114958002393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002394 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958002395 putative substrate translocation pore; other site 1114958002396 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 1114958002397 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1114958002398 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1114958002399 active site 1114958002400 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765 1114958002401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002402 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958002403 putative substrate translocation pore; other site 1114958002404 calcium/proton exchanger (cax); Region: cax; TIGR00378 1114958002405 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1114958002406 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1114958002407 YfkD-like protein; Region: YfkD; pfam14167 1114958002408 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1114958002409 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958002410 FeS/SAM binding site; other site 1114958002411 YfkB-like domain; Region: YfkB; pfam08756 1114958002412 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1114958002413 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1114958002414 NodB motif; other site 1114958002415 active site 1114958002416 catalytic site [active] 1114958002417 Cd binding site [ion binding]; other site 1114958002418 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1114958002419 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1114958002420 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1114958002421 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1114958002422 oligomer interface [polypeptide binding]; other site 1114958002423 metal binding site [ion binding]; metal-binding site 1114958002424 metal binding site [ion binding]; metal-binding site 1114958002425 putative Cl binding site [ion binding]; other site 1114958002426 aspartate ring; other site 1114958002427 basic sphincter; other site 1114958002428 hydrophobic gate; other site 1114958002429 periplasmic entrance; other site 1114958002430 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1114958002431 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1114958002432 minor groove reading motif; other site 1114958002433 helix-hairpin-helix signature motif; other site 1114958002434 substrate binding pocket [chemical binding]; other site 1114958002435 active site 1114958002436 TRAM domain; Region: TRAM; pfam01938 1114958002437 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1114958002438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958002439 S-adenosylmethionine binding site [chemical binding]; other site 1114958002440 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1114958002441 Phosphotransferase enzyme family; Region: APH; pfam01636 1114958002442 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1114958002443 substrate binding site [chemical binding]; other site 1114958002444 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958002445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958002446 Walker A/P-loop; other site 1114958002447 ATP binding site [chemical binding]; other site 1114958002448 Q-loop/lid; other site 1114958002449 ABC transporter signature motif; other site 1114958002450 Walker B; other site 1114958002451 D-loop; other site 1114958002452 H-loop/switch region; other site 1114958002453 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958002454 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114958002455 Walker A/P-loop; other site 1114958002456 ATP binding site [chemical binding]; other site 1114958002457 Q-loop/lid; other site 1114958002458 ABC transporter signature motif; other site 1114958002459 Walker B; other site 1114958002460 D-loop; other site 1114958002461 H-loop/switch region; other site 1114958002462 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1114958002463 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1114958002464 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114958002465 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114958002466 NAD(P) binding site [chemical binding]; other site 1114958002467 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1114958002468 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1114958002469 FMN binding site [chemical binding]; other site 1114958002470 active site 1114958002471 catalytic residues [active] 1114958002472 substrate binding site [chemical binding]; other site 1114958002473 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1114958002474 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1114958002475 tetramer interface [polypeptide binding]; other site 1114958002476 TPP-binding site [chemical binding]; other site 1114958002477 heterodimer interface [polypeptide binding]; other site 1114958002478 phosphorylation loop region [posttranslational modification] 1114958002479 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1114958002480 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1114958002481 alpha subunit interface [polypeptide binding]; other site 1114958002482 TPP binding site [chemical binding]; other site 1114958002483 heterodimer interface [polypeptide binding]; other site 1114958002484 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114958002485 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1114958002486 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114958002487 E3 interaction surface; other site 1114958002488 lipoyl attachment site [posttranslational modification]; other site 1114958002489 e3 binding domain; Region: E3_binding; pfam02817 1114958002490 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1114958002491 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1114958002492 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958002493 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114958002494 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1114958002495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958002496 Walker A motif; other site 1114958002497 ATP binding site [chemical binding]; other site 1114958002498 Walker B motif; other site 1114958002499 arginine finger; other site 1114958002500 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114958002501 Small acid-soluble spore protein H family; Region: SspH; pfam08141 1114958002502 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1114958002503 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1114958002504 NAD binding site [chemical binding]; other site 1114958002505 sugar binding site [chemical binding]; other site 1114958002506 divalent metal binding site [ion binding]; other site 1114958002507 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114958002508 dimer interface [polypeptide binding]; other site 1114958002509 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114958002510 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114958002511 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114958002512 putative active site [active] 1114958002513 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1114958002514 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1114958002515 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114958002516 active site turn [active] 1114958002517 phosphorylation site [posttranslational modification] 1114958002518 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114958002519 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114958002520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958002521 Walker A/P-loop; other site 1114958002522 ATP binding site [chemical binding]; other site 1114958002523 Q-loop/lid; other site 1114958002524 ABC transporter signature motif; other site 1114958002525 Walker B; other site 1114958002526 D-loop; other site 1114958002527 H-loop/switch region; other site 1114958002528 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114958002529 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114958002530 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1114958002531 Walker A/P-loop; other site 1114958002532 ATP binding site [chemical binding]; other site 1114958002533 Q-loop/lid; other site 1114958002534 ABC transporter signature motif; other site 1114958002535 Walker B; other site 1114958002536 D-loop; other site 1114958002537 H-loop/switch region; other site 1114958002538 Predicted membrane protein [Function unknown]; Region: COG2259 1114958002539 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1114958002540 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1114958002541 putative metal binding site [ion binding]; other site 1114958002542 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1114958002543 active site 1114958002544 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1114958002545 UbiA prenyltransferase family; Region: UbiA; pfam01040 1114958002546 Predicted transcriptional regulators [Transcription]; Region: COG1695 1114958002547 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1114958002548 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1114958002549 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1114958002550 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114958002551 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1114958002552 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1114958002553 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1114958002554 DNA polymerase phi; Region: DNA_pol_phi; pfam04931 1114958002555 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1114958002556 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1114958002557 RNAase interaction site [polypeptide binding]; other site 1114958002558 metal-dependent hydrolase; Provisional; Region: PRK13291 1114958002559 DinB superfamily; Region: DinB_2; pfam12867 1114958002560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002561 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958002562 putative substrate translocation pore; other site 1114958002563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002564 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958002565 MarR family; Region: MarR; pfam01047 1114958002566 Predicted integral membrane protein [Function unknown]; Region: COG0392 1114958002567 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1114958002568 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1114958002569 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1114958002570 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1114958002571 putative FMN binding site [chemical binding]; other site 1114958002572 YfhD-like protein; Region: YfhD; pfam14151 1114958002573 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1114958002574 TIGR01777 family protein; Region: yfcH 1114958002575 putative NAD(P) binding site [chemical binding]; other site 1114958002576 putative active site [active] 1114958002577 recombination regulator RecX; Provisional; Region: recX; PRK14135 1114958002578 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1114958002579 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114958002580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002581 putative substrate translocation pore; other site 1114958002582 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1114958002583 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1114958002584 acid-soluble spore protein K; Provisional; Region: sspK; PRK03081 1114958002585 WVELL protein; Region: WVELL; pfam14043 1114958002586 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1114958002587 Bacterial SH3 domain; Region: SH3_3; cl17532 1114958002588 SdpI/YhfL protein family; Region: SdpI; pfam13630 1114958002589 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1114958002590 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114958002591 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1114958002592 Ligand binding site; other site 1114958002593 Putative Catalytic site; other site 1114958002594 DXD motif; other site 1114958002595 Predicted membrane protein [Function unknown]; Region: COG4485 1114958002596 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1114958002597 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1114958002598 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1114958002599 minor groove reading motif; other site 1114958002600 helix-hairpin-helix signature motif; other site 1114958002601 substrate binding pocket [chemical binding]; other site 1114958002602 active site 1114958002603 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1114958002604 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1114958002605 DNA binding and oxoG recognition site [nucleotide binding] 1114958002606 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1114958002607 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1114958002608 putative NAD(P) binding site [chemical binding]; other site 1114958002609 active site 1114958002610 YgaB-like protein; Region: YgaB; pfam14182 1114958002611 hypothetical protein; Provisional; Region: PRK13662 1114958002612 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114958002613 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114958002614 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1114958002615 Walker A/P-loop; other site 1114958002616 ATP binding site [chemical binding]; other site 1114958002617 Q-loop/lid; other site 1114958002618 ABC transporter signature motif; other site 1114958002619 Walker B; other site 1114958002620 D-loop; other site 1114958002621 H-loop/switch region; other site 1114958002622 Predicted membrane protein [Function unknown]; Region: COG4129 1114958002623 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1114958002624 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1114958002625 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958002626 inhibitor-cofactor binding pocket; inhibition site 1114958002627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958002628 catalytic residue [active] 1114958002629 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1114958002630 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1114958002631 catalytic triad [active] 1114958002632 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1114958002633 metal binding site 2 [ion binding]; metal-binding site 1114958002634 putative DNA binding helix; other site 1114958002635 metal binding site 1 [ion binding]; metal-binding site 1114958002636 dimer interface [polypeptide binding]; other site 1114958002637 structural Zn2+ binding site [ion binding]; other site 1114958002638 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 1114958002639 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1114958002640 active site pocket [active] 1114958002641 oxyanion hole [active] 1114958002642 catalytic triad [active] 1114958002643 active site nucleophile [active] 1114958002644 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1114958002645 ThiC-associated domain; Region: ThiC-associated; pfam13667 1114958002646 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1114958002647 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114958002648 FAD binding domain; Region: FAD_binding_4; pfam01565 1114958002649 Berberine and berberine like; Region: BBE; pfam08031 1114958002650 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1114958002651 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114958002652 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1114958002653 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114958002654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958002655 dimer interface [polypeptide binding]; other site 1114958002656 conserved gate region; other site 1114958002657 putative PBP binding loops; other site 1114958002658 ABC-ATPase subunit interface; other site 1114958002659 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114958002660 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1114958002661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958002662 dimer interface [polypeptide binding]; other site 1114958002663 conserved gate region; other site 1114958002664 putative PBP binding loops; other site 1114958002665 ABC-ATPase subunit interface; other site 1114958002666 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114958002667 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114958002668 Walker A/P-loop; other site 1114958002669 ATP binding site [chemical binding]; other site 1114958002670 Q-loop/lid; other site 1114958002671 ABC transporter signature motif; other site 1114958002672 Walker B; other site 1114958002673 D-loop; other site 1114958002674 H-loop/switch region; other site 1114958002675 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1114958002676 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1114958002677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114958002678 Walker A/P-loop; other site 1114958002679 ATP binding site [chemical binding]; other site 1114958002680 Q-loop/lid; other site 1114958002681 ABC transporter signature motif; other site 1114958002682 Walker B; other site 1114958002683 D-loop; other site 1114958002684 H-loop/switch region; other site 1114958002685 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114958002686 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1114958002687 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1114958002688 tetramer interface [polypeptide binding]; other site 1114958002689 heme binding pocket [chemical binding]; other site 1114958002690 NADPH binding site [chemical binding]; other site 1114958002691 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1114958002692 active site 1114958002693 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1114958002694 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1114958002695 Walker A/P-loop; other site 1114958002696 ATP binding site [chemical binding]; other site 1114958002697 Q-loop/lid; other site 1114958002698 ABC transporter signature motif; other site 1114958002699 Walker B; other site 1114958002700 D-loop; other site 1114958002701 H-loop/switch region; other site 1114958002702 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1114958002703 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114958002704 substrate binding pocket [chemical binding]; other site 1114958002705 membrane-bound complex binding site; other site 1114958002706 hinge residues; other site 1114958002707 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1114958002708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958002709 dimer interface [polypeptide binding]; other site 1114958002710 conserved gate region; other site 1114958002711 putative PBP binding loops; other site 1114958002712 ABC-ATPase subunit interface; other site 1114958002713 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1114958002714 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1114958002715 active site 1114958002716 dimer interface [polypeptide binding]; other site 1114958002717 non-prolyl cis peptide bond; other site 1114958002718 insertion regions; other site 1114958002719 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1114958002720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958002721 non-specific DNA binding site [nucleotide binding]; other site 1114958002722 salt bridge; other site 1114958002723 sequence-specific DNA binding site [nucleotide binding]; other site 1114958002724 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1114958002725 epoxyqueuosine reductase; Region: TIGR00276 1114958002726 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1114958002727 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1114958002728 Putative amidase domain; Region: Amidase_6; pfam12671 1114958002729 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 1114958002730 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1114958002731 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1114958002732 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1114958002733 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1114958002734 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1114958002735 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1114958002736 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1114958002737 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958002738 MarR family; Region: MarR; pfam01047 1114958002739 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1114958002740 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114958002741 carboxyltransferase (CT) interaction site; other site 1114958002742 biotinylation site [posttranslational modification]; other site 1114958002743 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114958002744 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1114958002745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002746 putative substrate translocation pore; other site 1114958002747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958002748 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1114958002749 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114958002750 Predicted transcriptional regulators [Transcription]; Region: COG1725 1114958002751 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958002752 DNA-binding site [nucleotide binding]; DNA binding site 1114958002753 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114958002754 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1114958002755 Walker A/P-loop; other site 1114958002756 ATP binding site [chemical binding]; other site 1114958002757 Q-loop/lid; other site 1114958002758 ABC transporter signature motif; other site 1114958002759 Walker B; other site 1114958002760 D-loop; other site 1114958002761 H-loop/switch region; other site 1114958002762 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958002763 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958002764 Walker A/P-loop; other site 1114958002765 ATP binding site [chemical binding]; other site 1114958002766 Q-loop/lid; other site 1114958002767 ABC transporter signature motif; other site 1114958002768 Walker B; other site 1114958002769 D-loop; other site 1114958002770 H-loop/switch region; other site 1114958002771 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1114958002772 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1114958002773 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1114958002774 DNA-binding site [nucleotide binding]; DNA binding site 1114958002775 RNA-binding motif; other site 1114958002776 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1114958002777 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1114958002778 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1114958002779 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114958002780 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114958002781 metal binding site [ion binding]; metal-binding site 1114958002782 active site 1114958002783 I-site; other site 1114958002784 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1114958002785 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114958002786 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1114958002787 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1114958002788 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1114958002789 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1114958002790 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1114958002791 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1114958002792 putative active site [active] 1114958002793 putative metal binding site [ion binding]; other site 1114958002794 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1114958002795 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1114958002796 active site 1114958002797 catalytic site [active] 1114958002798 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1114958002799 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1114958002800 active site 1114958002801 FOG: CBS domain [General function prediction only]; Region: COG0517 1114958002802 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1114958002803 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1114958002804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958002805 motif II; other site 1114958002806 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114958002807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958002808 Coenzyme A binding pocket [chemical binding]; other site 1114958002809 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1114958002810 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1114958002811 putative active site [active] 1114958002812 catalytic triad [active] 1114958002813 putative dimer interface [polypeptide binding]; other site 1114958002814 aminotransferase; Validated; Region: PRK07678 1114958002815 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958002816 inhibitor-cofactor binding pocket; inhibition site 1114958002817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958002818 catalytic residue [active] 1114958002819 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1114958002820 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1114958002821 amphipathic channel; other site 1114958002822 Asn-Pro-Ala signature motifs; other site 1114958002823 glycerol kinase; Provisional; Region: glpK; PRK00047 1114958002824 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1114958002825 N- and C-terminal domain interface [polypeptide binding]; other site 1114958002826 active site 1114958002827 MgATP binding site [chemical binding]; other site 1114958002828 catalytic site [active] 1114958002829 metal binding site [ion binding]; metal-binding site 1114958002830 glycerol binding site [chemical binding]; other site 1114958002831 homotetramer interface [polypeptide binding]; other site 1114958002832 homodimer interface [polypeptide binding]; other site 1114958002833 FBP binding site [chemical binding]; other site 1114958002834 protein IIAGlc interface [polypeptide binding]; other site 1114958002835 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1114958002836 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1114958002837 active site 1114958002838 substrate binding site [chemical binding]; other site 1114958002839 metal binding site [ion binding]; metal-binding site 1114958002840 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1114958002841 GAF domain; Region: GAF; pfam01590 1114958002842 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1114958002843 Histidine kinase; Region: HisKA_3; pfam07730 1114958002844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958002845 ATP binding site [chemical binding]; other site 1114958002846 Mg2+ binding site [ion binding]; other site 1114958002847 G-X-G motif; other site 1114958002848 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958002849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958002850 active site 1114958002851 phosphorylation site [posttranslational modification] 1114958002852 intermolecular recognition site; other site 1114958002853 dimerization interface [polypeptide binding]; other site 1114958002854 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958002855 DNA binding residues [nucleotide binding] 1114958002856 Predicted flavoprotein [General function prediction only]; Region: COG0431 1114958002857 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114958002858 YhdB-like protein; Region: YhdB; pfam14148 1114958002859 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1114958002860 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958002861 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958002862 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1114958002863 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958002864 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958002865 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958002866 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1114958002867 NlpC/P60 family; Region: NLPC_P60; pfam00877 1114958002868 Predicted transcriptional regulator [Transcription]; Region: COG1959 1114958002869 Transcriptional regulator; Region: Rrf2; cl17282 1114958002870 Conserved TM helix; Region: TM_helix; pfam05552 1114958002871 Conserved TM helix; Region: TM_helix; pfam05552 1114958002872 Conserved TM helix; Region: TM_helix; pfam05552 1114958002873 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1114958002874 SpoVR like protein; Region: SpoVR; pfam04293 1114958002875 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1114958002876 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1114958002877 dimer interface [polypeptide binding]; other site 1114958002878 active site 1114958002879 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958002880 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958002881 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1114958002882 NlpC/P60 family; Region: NLPC_P60; pfam00877 1114958002883 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958002884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958002885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958002886 dimerization interface [polypeptide binding]; other site 1114958002887 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1114958002888 dimer interface [polypeptide binding]; other site 1114958002889 Citrate synthase; Region: Citrate_synt; pfam00285 1114958002890 active site 1114958002891 citrylCoA binding site [chemical binding]; other site 1114958002892 oxalacetate/citrate binding site [chemical binding]; other site 1114958002893 coenzyme A binding site [chemical binding]; other site 1114958002894 catalytic triad [active] 1114958002895 short chain dehydrogenase; Provisional; Region: PRK06701 1114958002896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958002897 NAD(P) binding site [chemical binding]; other site 1114958002898 active site 1114958002899 amino acid transporter; Region: 2A0306; TIGR00909 1114958002900 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1114958002901 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1114958002902 Na2 binding site [ion binding]; other site 1114958002903 putative substrate binding site 1 [chemical binding]; other site 1114958002904 Na binding site 1 [ion binding]; other site 1114958002905 putative substrate binding site 2 [chemical binding]; other site 1114958002906 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1114958002907 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1114958002908 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1114958002909 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958002910 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958002911 DNA binding residues [nucleotide binding] 1114958002912 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1114958002913 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1114958002914 putative acyl-acceptor binding pocket; other site 1114958002915 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1114958002916 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114958002917 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114958002918 Transporter associated domain; Region: CorC_HlyC; smart01091 1114958002919 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1114958002920 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114958002921 DNA binding residues [nucleotide binding] 1114958002922 putative dimer interface [polypeptide binding]; other site 1114958002923 aspartate aminotransferase; Provisional; Region: PRK06836 1114958002924 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958002925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958002926 homodimer interface [polypeptide binding]; other site 1114958002927 catalytic residue [active] 1114958002928 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1114958002929 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114958002930 dimer interface [polypeptide binding]; other site 1114958002931 active site 1114958002932 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1114958002933 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114958002934 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114958002935 Transporter associated domain; Region: CorC_HlyC; smart01091 1114958002936 camphor resistance protein CrcB; Provisional; Region: PRK14213 1114958002937 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1114958002938 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1114958002939 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1114958002940 active site 1114958002941 catalytic site [active] 1114958002942 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1114958002943 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114958002944 NAD-dependent deacetylase; Provisional; Region: PRK00481 1114958002945 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1114958002946 NAD+ binding site [chemical binding]; other site 1114958002947 substrate binding site [chemical binding]; other site 1114958002948 Zn binding site [ion binding]; other site 1114958002949 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1114958002950 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1114958002951 NodB motif; other site 1114958002952 active site 1114958002953 catalytic site [active] 1114958002954 Zn binding site [ion binding]; other site 1114958002955 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1114958002956 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1114958002957 homodimer interface [polypeptide binding]; other site 1114958002958 substrate-cofactor binding pocket; other site 1114958002959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958002960 catalytic residue [active] 1114958002961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958002962 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1114958002963 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114958002964 Ligand Binding Site [chemical binding]; other site 1114958002965 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114958002966 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114958002967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958002968 Walker A/P-loop; other site 1114958002969 ATP binding site [chemical binding]; other site 1114958002970 Q-loop/lid; other site 1114958002971 ABC transporter signature motif; other site 1114958002972 Walker B; other site 1114958002973 D-loop; other site 1114958002974 H-loop/switch region; other site 1114958002975 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114958002976 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114958002977 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1114958002978 Walker A/P-loop; other site 1114958002979 ATP binding site [chemical binding]; other site 1114958002980 Q-loop/lid; other site 1114958002981 ABC transporter signature motif; other site 1114958002982 Walker B; other site 1114958002983 D-loop; other site 1114958002984 H-loop/switch region; other site 1114958002985 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1114958002986 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1114958002987 NAD binding site [chemical binding]; other site 1114958002988 substrate binding site [chemical binding]; other site 1114958002989 putative active site [active] 1114958002990 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1114958002991 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1114958002992 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1114958002993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1114958002994 hypothetical protein; Provisional; Region: PRK13676 1114958002995 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1114958002996 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1114958002997 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958002998 active site 1114958002999 motif I; other site 1114958003000 motif II; other site 1114958003001 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114958003002 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1114958003003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958003004 FeS/SAM binding site; other site 1114958003005 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1114958003006 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114958003007 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1114958003008 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1114958003009 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1114958003010 TrkA-C domain; Region: TrkA_C; pfam02080 1114958003011 enoyl-CoA hydratase; Provisional; Region: PRK07659 1114958003012 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958003013 substrate binding site [chemical binding]; other site 1114958003014 oxyanion hole (OAH) forming residues; other site 1114958003015 trimer interface [polypeptide binding]; other site 1114958003016 YhzD-like protein; Region: YhzD; pfam14120 1114958003017 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1114958003018 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 1114958003019 Walker A/P-loop; other site 1114958003020 ATP binding site [chemical binding]; other site 1114958003021 Q-loop/lid; other site 1114958003022 ABC transporter signature motif; other site 1114958003023 Walker B; other site 1114958003024 D-loop; other site 1114958003025 H-loop/switch region; other site 1114958003026 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1114958003027 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1114958003028 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1114958003029 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1114958003030 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114958003031 active site 1114958003032 metal binding site [ion binding]; metal-binding site 1114958003033 DNA binding site [nucleotide binding] 1114958003034 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1114958003035 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1114958003036 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1114958003037 generic binding surface II; other site 1114958003038 generic binding surface I; other site 1114958003039 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114958003040 Zn2+ binding site [ion binding]; other site 1114958003041 Mg2+ binding site [ion binding]; other site 1114958003042 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1114958003043 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1114958003044 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1114958003045 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1114958003046 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1114958003047 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1114958003048 transcriptional regulator Hpr; Provisional; Region: PRK13777 1114958003049 MarR family; Region: MarR; pfam01047 1114958003050 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1114958003051 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1114958003052 homodimer interface [polypeptide binding]; other site 1114958003053 substrate-cofactor binding pocket; other site 1114958003054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958003055 catalytic residue [active] 1114958003056 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1114958003057 HIT family signature motif; other site 1114958003058 catalytic residue [active] 1114958003059 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1114958003060 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114958003061 Walker A/P-loop; other site 1114958003062 ATP binding site [chemical binding]; other site 1114958003063 Q-loop/lid; other site 1114958003064 ABC transporter signature motif; other site 1114958003065 Walker B; other site 1114958003066 D-loop; other site 1114958003067 H-loop/switch region; other site 1114958003068 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1114958003069 EcsC protein family; Region: EcsC; pfam12787 1114958003070 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1114958003071 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1114958003072 metal binding site [ion binding]; metal-binding site 1114958003073 dimer interface [polypeptide binding]; other site 1114958003074 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1114958003075 Transglycosylase; Region: Transgly; pfam00912 1114958003076 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1114958003077 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1114958003078 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1114958003079 substrate binding site [chemical binding]; other site 1114958003080 active site 1114958003081 ferrochelatase; Provisional; Region: PRK12435 1114958003082 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1114958003083 C-terminal domain interface [polypeptide binding]; other site 1114958003084 active site 1114958003085 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1114958003086 active site 1114958003087 N-terminal domain interface [polypeptide binding]; other site 1114958003088 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1114958003089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114958003090 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958003091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958003092 Predicted membrane protein [Function unknown]; Region: COG1511 1114958003093 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1114958003094 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1114958003095 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1114958003096 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1114958003097 dimer interface [polypeptide binding]; other site 1114958003098 active site 1114958003099 CoA binding pocket [chemical binding]; other site 1114958003100 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1114958003101 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1114958003102 putative oligomer interface [polypeptide binding]; other site 1114958003103 putative active site [active] 1114958003104 metal binding site [ion binding]; metal-binding site 1114958003105 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1114958003106 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1114958003107 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1114958003108 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1114958003109 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1114958003110 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1114958003111 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1114958003112 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1114958003113 NAD(P) binding site [chemical binding]; other site 1114958003114 putative active site [active] 1114958003115 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1114958003116 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1114958003117 acyl-activating enzyme (AAE) consensus motif; other site 1114958003118 putative AMP binding site [chemical binding]; other site 1114958003119 putative active site [active] 1114958003120 putative CoA binding site [chemical binding]; other site 1114958003121 Peptidase family M48; Region: Peptidase_M48; pfam01435 1114958003122 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1114958003123 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1114958003124 active site 1114958003125 catalytic residues [active] 1114958003126 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1114958003127 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1114958003128 siderophore binding site; other site 1114958003129 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1114958003130 catalytic core [active] 1114958003131 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1114958003132 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114958003133 dimer interface [polypeptide binding]; other site 1114958003134 active site 1114958003135 acyl-CoA synthetase; Validated; Region: PRK07638 1114958003136 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114958003137 acyl-activating enzyme (AAE) consensus motif; other site 1114958003138 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1114958003139 acyl-activating enzyme (AAE) consensus motif; other site 1114958003140 AMP binding site [chemical binding]; other site 1114958003141 active site 1114958003142 CoA binding site [chemical binding]; other site 1114958003143 BioY family; Region: BioY; pfam02632 1114958003144 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1114958003145 heme-binding site [chemical binding]; other site 1114958003146 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114958003147 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958003148 dimer interface [polypeptide binding]; other site 1114958003149 putative CheW interface [polypeptide binding]; other site 1114958003150 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1114958003151 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114958003152 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1114958003153 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1114958003154 [2Fe-2S] cluster binding site [ion binding]; other site 1114958003155 short chain dehydrogenase; Provisional; Region: PRK06701 1114958003156 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1114958003157 NAD binding site [chemical binding]; other site 1114958003158 metal binding site [ion binding]; metal-binding site 1114958003159 active site 1114958003160 A short protein domain of unknown function; Region: IDEAL; smart00914 1114958003161 Genetic competence transcription factor [Transcription]; Region: ComK; COG4903 1114958003162 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1114958003163 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1114958003164 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1114958003165 putative binding site; other site 1114958003166 putative dimer interface [polypeptide binding]; other site 1114958003167 Excalibur calcium-binding domain; Region: Excalibur; cl05460 1114958003168 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1114958003169 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1114958003170 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1114958003171 Na binding site [ion binding]; other site 1114958003172 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1114958003173 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1114958003174 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1114958003175 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1114958003176 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1114958003177 Catalytic site [active] 1114958003178 hypothetical protein; Provisional; Region: PRK08244 1114958003179 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1114958003180 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958003181 MarR family; Region: MarR; pfam01047 1114958003182 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1114958003183 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1114958003184 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1114958003185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958003186 putative substrate translocation pore; other site 1114958003187 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958003188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958003189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958003190 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1114958003191 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1114958003192 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1114958003193 dinuclear metal binding motif [ion binding]; other site 1114958003194 Predicted membrane protein [Function unknown]; Region: COG2323 1114958003195 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1114958003196 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1114958003197 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1114958003198 Part of AAA domain; Region: AAA_19; pfam13245 1114958003199 Family description; Region: UvrD_C_2; pfam13538 1114958003200 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1114958003201 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1114958003202 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1114958003203 active site 1114958003204 metal binding site [ion binding]; metal-binding site 1114958003205 DNA binding site [nucleotide binding] 1114958003206 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1114958003207 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1114958003208 AAA domain; Region: AAA_23; pfam13476 1114958003209 Walker A/P-loop; other site 1114958003210 ATP binding site [chemical binding]; other site 1114958003211 Q-loop/lid; other site 1114958003212 ABC transporter signature motif; other site 1114958003213 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1114958003214 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1114958003215 ABC transporter signature motif; other site 1114958003216 Walker B; other site 1114958003217 D-loop; other site 1114958003218 H-loop/switch region; other site 1114958003219 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1114958003220 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1114958003221 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1114958003222 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1114958003223 Spore germination protein GerPC; Region: GerPC; pfam10737 1114958003224 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1114958003225 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1114958003226 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1114958003227 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1114958003228 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1114958003229 hypothetical protein; Provisional; Region: PRK13673 1114958003230 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1114958003231 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1114958003232 active site 1114958003233 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1114958003234 dimer interface [polypeptide binding]; other site 1114958003235 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1114958003236 Ligand Binding Site [chemical binding]; other site 1114958003237 Molecular Tunnel; other site 1114958003238 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 1114958003239 substrate binding pocket [chemical binding]; other site 1114958003240 substrate-Mg2+ binding site; other site 1114958003241 aspartate-rich region 1; other site 1114958003242 aspartate-rich region 2; other site 1114958003243 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1114958003244 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1114958003245 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1114958003246 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1114958003247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958003248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958003249 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958003250 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958003251 DNA binding site [nucleotide binding] 1114958003252 domain linker motif; other site 1114958003253 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1114958003254 dimerization interface [polypeptide binding]; other site 1114958003255 ligand binding site [chemical binding]; other site 1114958003256 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114958003257 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114958003258 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114958003259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1114958003260 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1114958003261 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1114958003262 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1114958003263 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1114958003264 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1114958003265 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1114958003266 FAD binding site [chemical binding]; other site 1114958003267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1114958003268 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1114958003269 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1114958003270 S1 domain; Region: S1_2; pfam13509 1114958003271 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1114958003272 RNA binding site [nucleotide binding]; other site 1114958003273 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1114958003274 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1114958003275 ligand binding site [chemical binding]; other site 1114958003276 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958003277 dimerization interface [polypeptide binding]; other site 1114958003278 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114958003279 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958003280 dimer interface [polypeptide binding]; other site 1114958003281 putative CheW interface [polypeptide binding]; other site 1114958003282 EDD domain protein, DegV family; Region: DegV; TIGR00762 1114958003283 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1114958003284 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958003285 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958003286 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958003287 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1114958003288 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1114958003289 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1114958003290 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958003291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958003292 motif II; other site 1114958003293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958003294 esterase; Provisional; Region: PRK10566 1114958003295 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1114958003296 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1114958003297 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1114958003298 active site 1114958003299 metal binding site [ion binding]; metal-binding site 1114958003300 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1114958003301 FAD binding domain; Region: FAD_binding_4; pfam01565 1114958003302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958003303 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958003304 putative substrate translocation pore; other site 1114958003305 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1114958003306 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1114958003307 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1114958003308 heterotetramer interface [polypeptide binding]; other site 1114958003309 active site pocket [active] 1114958003310 cleavage site 1114958003311 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1114958003312 nucleotide binding site [chemical binding]; other site 1114958003313 N-acetyl-L-glutamate binding site [chemical binding]; other site 1114958003314 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1114958003315 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958003316 inhibitor-cofactor binding pocket; inhibition site 1114958003317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958003318 catalytic residue [active] 1114958003319 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1114958003320 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1114958003321 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1114958003322 catalytic site [active] 1114958003323 subunit interface [polypeptide binding]; other site 1114958003324 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1114958003325 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958003326 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1114958003327 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1114958003328 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958003329 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1114958003330 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1114958003331 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1114958003332 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1114958003333 YjzC-like protein; Region: YjzC; pfam14168 1114958003334 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1114958003335 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114958003336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958003337 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1114958003338 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1114958003339 putative ligand binding site [chemical binding]; other site 1114958003340 ComZ; Region: ComZ; pfam10815 1114958003341 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1114958003342 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1114958003343 dimer interface [polypeptide binding]; other site 1114958003344 active site 1114958003345 CoA binding pocket [chemical binding]; other site 1114958003346 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1114958003347 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1114958003348 dimer interface [polypeptide binding]; other site 1114958003349 active site 1114958003350 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 1114958003351 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114958003352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114958003353 Walker A/P-loop; other site 1114958003354 ATP binding site [chemical binding]; other site 1114958003355 Q-loop/lid; other site 1114958003356 ABC transporter signature motif; other site 1114958003357 Walker B; other site 1114958003358 D-loop; other site 1114958003359 H-loop/switch region; other site 1114958003360 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1114958003361 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1114958003362 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114958003363 Walker A/P-loop; other site 1114958003364 ATP binding site [chemical binding]; other site 1114958003365 Q-loop/lid; other site 1114958003366 ABC transporter signature motif; other site 1114958003367 Walker B; other site 1114958003368 D-loop; other site 1114958003369 H-loop/switch region; other site 1114958003370 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1114958003371 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1114958003372 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1114958003373 peptide binding site [polypeptide binding]; other site 1114958003374 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114958003375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958003376 dimer interface [polypeptide binding]; other site 1114958003377 conserved gate region; other site 1114958003378 putative PBP binding loops; other site 1114958003379 ABC-ATPase subunit interface; other site 1114958003380 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114958003381 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1114958003382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958003383 dimer interface [polypeptide binding]; other site 1114958003384 conserved gate region; other site 1114958003385 putative PBP binding loops; other site 1114958003386 ABC-ATPase subunit interface; other site 1114958003387 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1114958003388 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1114958003389 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1114958003390 active site 1114958003391 HIGH motif; other site 1114958003392 dimer interface [polypeptide binding]; other site 1114958003393 KMSKS motif; other site 1114958003394 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1114958003395 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1114958003396 peptide binding site [polypeptide binding]; other site 1114958003397 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1114958003398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958003399 dimer interface [polypeptide binding]; other site 1114958003400 conserved gate region; other site 1114958003401 putative PBP binding loops; other site 1114958003402 ABC-ATPase subunit interface; other site 1114958003403 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114958003404 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1114958003405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958003406 dimer interface [polypeptide binding]; other site 1114958003407 conserved gate region; other site 1114958003408 putative PBP binding loops; other site 1114958003409 ABC-ATPase subunit interface; other site 1114958003410 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114958003411 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114958003412 Walker A/P-loop; other site 1114958003413 ATP binding site [chemical binding]; other site 1114958003414 Q-loop/lid; other site 1114958003415 ABC transporter signature motif; other site 1114958003416 Walker B; other site 1114958003417 D-loop; other site 1114958003418 H-loop/switch region; other site 1114958003419 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114958003420 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1114958003421 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114958003422 Walker A/P-loop; other site 1114958003423 ATP binding site [chemical binding]; other site 1114958003424 Q-loop/lid; other site 1114958003425 ABC transporter signature motif; other site 1114958003426 Walker B; other site 1114958003427 D-loop; other site 1114958003428 H-loop/switch region; other site 1114958003429 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1114958003430 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1114958003431 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1114958003432 Coenzyme A binding pocket [chemical binding]; other site 1114958003433 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1114958003434 ArsC family; Region: ArsC; pfam03960 1114958003435 putative catalytic residues [active] 1114958003436 thiol/disulfide switch; other site 1114958003437 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1114958003438 adaptor protein; Provisional; Region: PRK02315 1114958003439 Competence protein CoiA-like family; Region: CoiA; cl11541 1114958003440 oligoendopeptidase F; Region: pepF; TIGR00181 1114958003441 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1114958003442 active site 1114958003443 Zn binding site [ion binding]; other site 1114958003444 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1114958003445 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1114958003446 catalytic residues [active] 1114958003447 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1114958003448 apolar tunnel; other site 1114958003449 heme binding site [chemical binding]; other site 1114958003450 dimerization interface [polypeptide binding]; other site 1114958003451 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1114958003452 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1114958003453 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114958003454 catalytic residue [active] 1114958003455 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1114958003456 putative active site [active] 1114958003457 putative metal binding residues [ion binding]; other site 1114958003458 signature motif; other site 1114958003459 putative triphosphate binding site [ion binding]; other site 1114958003460 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1114958003461 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1114958003462 synthetase active site [active] 1114958003463 NTP binding site [chemical binding]; other site 1114958003464 metal binding site [ion binding]; metal-binding site 1114958003465 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1114958003466 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1114958003467 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1114958003468 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1114958003469 active site 1114958003470 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1114958003471 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1114958003472 active site 1114958003473 metal binding site [ion binding]; metal-binding site 1114958003474 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1114958003475 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1114958003476 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1114958003477 TrkA-N domain; Region: TrkA_N; pfam02254 1114958003478 TrkA-C domain; Region: TrkA_C; pfam02080 1114958003479 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1114958003480 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1114958003481 thiamine phosphate binding site [chemical binding]; other site 1114958003482 active site 1114958003483 pyrophosphate binding site [ion binding]; other site 1114958003484 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1114958003485 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1114958003486 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1114958003487 thiS-thiF/thiG interaction site; other site 1114958003488 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1114958003489 ThiS interaction site; other site 1114958003490 putative active site [active] 1114958003491 tetramer interface [polypeptide binding]; other site 1114958003492 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1114958003493 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1114958003494 ATP binding site [chemical binding]; other site 1114958003495 substrate interface [chemical binding]; other site 1114958003496 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1114958003497 dimer interface [polypeptide binding]; other site 1114958003498 substrate binding site [chemical binding]; other site 1114958003499 ATP binding site [chemical binding]; other site 1114958003500 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1114958003501 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1114958003502 NAD binding site [chemical binding]; other site 1114958003503 homotetramer interface [polypeptide binding]; other site 1114958003504 homodimer interface [polypeptide binding]; other site 1114958003505 substrate binding site [chemical binding]; other site 1114958003506 active site 1114958003507 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1114958003508 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1114958003509 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1114958003510 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1114958003511 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1114958003512 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1114958003513 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1114958003514 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1114958003515 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1114958003516 Part of AAA domain; Region: AAA_19; pfam13245 1114958003517 Family description; Region: UvrD_C_2; pfam13538 1114958003518 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114958003519 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1114958003520 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1114958003521 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1114958003522 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1114958003523 Walker A/P-loop; other site 1114958003524 ATP binding site [chemical binding]; other site 1114958003525 Q-loop/lid; other site 1114958003526 ABC transporter signature motif; other site 1114958003527 Walker B; other site 1114958003528 D-loop; other site 1114958003529 H-loop/switch region; other site 1114958003530 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1114958003531 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1114958003532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958003533 Coenzyme A binding pocket [chemical binding]; other site 1114958003534 hypothetical protein; Provisional; Region: PRK13679 1114958003535 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1114958003536 Putative esterase; Region: Esterase; pfam00756 1114958003537 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1114958003538 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1114958003539 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1114958003540 homodimer interface [polypeptide binding]; other site 1114958003541 substrate-cofactor binding pocket; other site 1114958003542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958003543 catalytic residue [active] 1114958003544 cystathionine beta-lyase; Provisional; Region: PRK08064 1114958003545 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1114958003546 homodimer interface [polypeptide binding]; other site 1114958003547 substrate-cofactor binding pocket; other site 1114958003548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958003549 catalytic residue [active] 1114958003550 LXG domain of WXG superfamily; Region: LXG; pfam04740 1114958003551 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958003552 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1114958003553 active site 1114958003554 metal binding site [ion binding]; metal-binding site 1114958003555 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1114958003556 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1114958003557 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1114958003558 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958003559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958003560 putative substrate translocation pore; other site 1114958003561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958003562 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958003563 putative Zn2+ binding site [ion binding]; other site 1114958003564 putative DNA binding site [nucleotide binding]; other site 1114958003565 dimerization interface [polypeptide binding]; other site 1114958003566 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1114958003567 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1114958003568 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1114958003569 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1114958003570 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1114958003571 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1114958003572 NAD binding site [chemical binding]; other site 1114958003573 homodimer interface [polypeptide binding]; other site 1114958003574 active site 1114958003575 substrate binding site [chemical binding]; other site 1114958003576 galactokinase; Provisional; Region: PRK05322 1114958003577 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1114958003578 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1114958003579 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1114958003580 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1114958003581 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1114958003582 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 1114958003583 active site 1114958003584 P-loop; other site 1114958003585 phosphorylation site [posttranslational modification] 1114958003586 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1114958003587 methionine cluster; other site 1114958003588 active site 1114958003589 phosphorylation site [posttranslational modification] 1114958003590 metal binding site [ion binding]; metal-binding site 1114958003591 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 1114958003592 beta-galactosidase; Region: BGL; TIGR03356 1114958003593 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114958003594 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1114958003595 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114958003596 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1114958003597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958003598 motif II; other site 1114958003599 MgtC family; Region: MgtC; pfam02308 1114958003600 Putative motility protein; Region: YjfB_motility; pfam14070 1114958003601 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1114958003602 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1114958003603 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1114958003604 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114958003605 catalytic loop [active] 1114958003606 iron binding site [ion binding]; other site 1114958003607 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1114958003608 4Fe-4S binding domain; Region: Fer4; pfam00037 1114958003609 4Fe-4S binding domain; Region: Fer4; pfam00037 1114958003610 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1114958003611 [4Fe-4S] binding site [ion binding]; other site 1114958003612 molybdopterin cofactor binding site; other site 1114958003613 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1114958003614 molybdopterin cofactor binding site; other site 1114958003615 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1114958003616 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1114958003617 Cytochrome P450; Region: p450; cl12078 1114958003618 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1114958003619 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1114958003620 active site 1114958003621 TDP-binding site; other site 1114958003622 acceptor substrate-binding pocket; other site 1114958003623 homodimer interface [polypeptide binding]; other site 1114958003624 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1114958003625 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1114958003626 active site 1114958003627 TIGR00245 family protein; Region: TIGR00245 1114958003628 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1114958003629 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1114958003630 Walker A/P-loop; other site 1114958003631 ATP binding site [chemical binding]; other site 1114958003632 Q-loop/lid; other site 1114958003633 ABC transporter signature motif; other site 1114958003634 Walker B; other site 1114958003635 D-loop; other site 1114958003636 H-loop/switch region; other site 1114958003637 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1114958003638 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 1114958003639 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1114958003640 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1114958003641 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958003642 Glucuronate isomerase; Region: UxaC; pfam02614 1114958003643 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1114958003644 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1114958003645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958003646 putative substrate translocation pore; other site 1114958003647 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958003648 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958003649 DNA binding site [nucleotide binding] 1114958003650 domain linker motif; other site 1114958003651 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1114958003652 dimerization interface [polypeptide binding]; other site 1114958003653 ligand binding site [chemical binding]; other site 1114958003654 altronate oxidoreductase; Provisional; Region: PRK03643 1114958003655 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1114958003656 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1114958003657 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1114958003658 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1114958003659 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1114958003660 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958003661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958003662 active site 1114958003663 phosphorylation site [posttranslational modification] 1114958003664 intermolecular recognition site; other site 1114958003665 dimerization interface [polypeptide binding]; other site 1114958003666 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958003667 DNA binding site [nucleotide binding] 1114958003668 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958003669 HAMP domain; Region: HAMP; pfam00672 1114958003670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958003671 dimer interface [polypeptide binding]; other site 1114958003672 phosphorylation site [posttranslational modification] 1114958003673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958003674 ATP binding site [chemical binding]; other site 1114958003675 Mg2+ binding site [ion binding]; other site 1114958003676 G-X-G motif; other site 1114958003677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958003678 Walker A/P-loop; other site 1114958003679 ATP binding site [chemical binding]; other site 1114958003680 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114958003681 DinB family; Region: DinB; cl17821 1114958003682 DinB superfamily; Region: DinB_2; pfam12867 1114958003683 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958003684 binding surface 1114958003685 TPR motif; other site 1114958003686 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958003687 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958003688 binding surface 1114958003689 TPR motif; other site 1114958003690 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1114958003691 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114958003692 amidase catalytic site [active] 1114958003693 Zn binding residues [ion binding]; other site 1114958003694 substrate binding site [chemical binding]; other site 1114958003695 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1114958003696 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958003697 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1114958003698 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1114958003699 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1114958003700 pentamer interface [polypeptide binding]; other site 1114958003701 dodecaamer interface [polypeptide binding]; other site 1114958003702 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1114958003703 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1114958003704 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114958003705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958003706 non-specific DNA binding site [nucleotide binding]; other site 1114958003707 salt bridge; other site 1114958003708 sequence-specific DNA binding site [nucleotide binding]; other site 1114958003709 hypothetical protein; Provisional; Region: PRK06921 1114958003710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958003711 Walker A motif; other site 1114958003712 ATP binding site [chemical binding]; other site 1114958003713 Walker B motif; other site 1114958003714 positive control sigma-like factor; Validated; Region: PRK06930 1114958003715 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958003716 DNA binding residues [nucleotide binding] 1114958003717 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1114958003718 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 1114958003719 Phage terminase large subunit [General function prediction only]; Region: XtmB; COG1783 1114958003720 Bacteriophage capsid portal protein [General function prediction only]; Region: COG5518 1114958003721 Phage capsid family; Region: Phage_capsid; pfam05065 1114958003722 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1114958003723 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1114958003724 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1114958003725 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1114958003726 Phage XkdN-like protein; Region: XkdN; pfam08890 1114958003727 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1114958003728 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1114958003729 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114958003730 catalytic residue [active] 1114958003731 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1114958003732 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958003733 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1114958003734 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1114958003735 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1114958003736 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 1114958003737 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 1114958003738 XkdW protein; Region: XkdW; pfam09636 1114958003739 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1114958003740 Haemolysin XhlA; Region: XhlA; pfam10779 1114958003741 Phage lysis protein, holin; Region: Phage_holin; pfam04688 1114958003742 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114958003743 amidase catalytic site [active] 1114958003744 Zn binding residues [ion binding]; other site 1114958003745 substrate binding site [chemical binding]; other site 1114958003746 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958003747 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1114958003748 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1114958003749 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1114958003750 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1114958003751 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1114958003752 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1114958003753 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1114958003754 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1114958003755 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958003756 Zn binding site [ion binding]; other site 1114958003757 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1114958003758 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958003759 Zn binding site [ion binding]; other site 1114958003760 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1114958003761 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1114958003762 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1114958003763 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1114958003764 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1114958003765 Ligand binding site; other site 1114958003766 Putative Catalytic site; other site 1114958003767 DXD motif; other site 1114958003768 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1114958003769 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114958003770 protein binding site [polypeptide binding]; other site 1114958003771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958003772 putative substrate translocation pore; other site 1114958003773 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958003774 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1114958003775 SxDxEG motif; other site 1114958003776 active site 1114958003777 metal binding site [ion binding]; metal-binding site 1114958003778 homopentamer interface [polypeptide binding]; other site 1114958003779 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1114958003780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958003781 dimer interface [polypeptide binding]; other site 1114958003782 conserved gate region; other site 1114958003783 putative PBP binding loops; other site 1114958003784 ABC-ATPase subunit interface; other site 1114958003785 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1114958003786 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1114958003787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958003788 dimer interface [polypeptide binding]; other site 1114958003789 conserved gate region; other site 1114958003790 putative PBP binding loops; other site 1114958003791 ABC-ATPase subunit interface; other site 1114958003792 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1114958003793 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114958003794 Walker A/P-loop; other site 1114958003795 ATP binding site [chemical binding]; other site 1114958003796 Q-loop/lid; other site 1114958003797 ABC transporter signature motif; other site 1114958003798 Walker B; other site 1114958003799 D-loop; other site 1114958003800 H-loop/switch region; other site 1114958003801 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114958003802 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1114958003803 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1114958003804 peptide binding site [polypeptide binding]; other site 1114958003805 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1114958003806 dimer interface [polypeptide binding]; other site 1114958003807 catalytic triad [active] 1114958003808 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1114958003809 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1114958003810 active site 1114958003811 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1114958003812 NlpC/P60 family; Region: NLPC_P60; pfam00877 1114958003813 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1114958003814 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1114958003815 Walker A/P-loop; other site 1114958003816 ATP binding site [chemical binding]; other site 1114958003817 Q-loop/lid; other site 1114958003818 ABC transporter signature motif; other site 1114958003819 Walker B; other site 1114958003820 D-loop; other site 1114958003821 H-loop/switch region; other site 1114958003822 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1114958003823 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1114958003824 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1114958003825 Amidinotransferase; Region: Amidinotransf; pfam02274 1114958003826 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1114958003827 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114958003828 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1114958003829 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1114958003830 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1114958003831 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1114958003832 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1114958003833 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1114958003834 putative active site [active] 1114958003835 putative substrate binding site [chemical binding]; other site 1114958003836 putative cosubstrate binding site; other site 1114958003837 catalytic site [active] 1114958003838 gamma-glutamyl kinase; Provisional; Region: PRK05429 1114958003839 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1114958003840 nucleotide binding site [chemical binding]; other site 1114958003841 homotetrameric interface [polypeptide binding]; other site 1114958003842 putative phosphate binding site [ion binding]; other site 1114958003843 putative allosteric binding site; other site 1114958003844 PUA domain; Region: PUA; pfam01472 1114958003845 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1114958003846 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1114958003847 putative catalytic cysteine [active] 1114958003848 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1114958003849 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958003850 MarR family; Region: MarR; pfam01047 1114958003851 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1114958003852 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1114958003853 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1114958003854 putative metal binding site; other site 1114958003855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958003856 binding surface 1114958003857 TPR motif; other site 1114958003858 TPR repeat; Region: TPR_11; pfam13414 1114958003859 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1114958003860 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1114958003861 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1114958003862 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114958003863 ligand binding site [chemical binding]; other site 1114958003864 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1114958003865 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1114958003866 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1114958003867 THF binding site; other site 1114958003868 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1114958003869 substrate binding site [chemical binding]; other site 1114958003870 THF binding site; other site 1114958003871 zinc-binding site [ion binding]; other site 1114958003872 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1114958003873 active site 1114958003874 catalytic residues [active] 1114958003875 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1114958003876 Cobalt transport protein; Region: CbiQ; pfam02361 1114958003877 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1114958003878 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1114958003879 Walker A/P-loop; other site 1114958003880 ATP binding site [chemical binding]; other site 1114958003881 Q-loop/lid; other site 1114958003882 ABC transporter signature motif; other site 1114958003883 Walker B; other site 1114958003884 D-loop; other site 1114958003885 H-loop/switch region; other site 1114958003886 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1114958003887 Walker A/P-loop; other site 1114958003888 ATP binding site [chemical binding]; other site 1114958003889 Q-loop/lid; other site 1114958003890 ABC transporter signature motif; other site 1114958003891 Walker B; other site 1114958003892 D-loop; other site 1114958003893 H-loop/switch region; other site 1114958003894 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1114958003895 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1114958003896 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958003897 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958003898 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1114958003899 active site 1114958003900 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1114958003901 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1114958003902 MgtE intracellular N domain; Region: MgtE_N; smart00924 1114958003903 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1114958003904 Divalent cation transporter; Region: MgtE; pfam01769 1114958003905 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1114958003906 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1114958003907 DNA binding residues [nucleotide binding] 1114958003908 putative dimer interface [polypeptide binding]; other site 1114958003909 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958003910 MarR family; Region: MarR; pfam01047 1114958003911 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1114958003912 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1114958003913 active site 1114958003914 DNA binding site [nucleotide binding] 1114958003915 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1114958003916 nucleotide binding site [chemical binding]; other site 1114958003917 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 1114958003918 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1114958003919 putative DNA binding site [nucleotide binding]; other site 1114958003920 putative homodimer interface [polypeptide binding]; other site 1114958003921 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1114958003922 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1114958003923 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1114958003924 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1114958003925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958003926 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1114958003927 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1114958003928 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1114958003929 heat shock protein HtpX; Provisional; Region: PRK05457 1114958003930 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1114958003931 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1114958003932 Predicted membrane protein [Function unknown]; Region: COG2323 1114958003933 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1114958003934 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1114958003935 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958003936 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114958003937 putative active site [active] 1114958003938 heme pocket [chemical binding]; other site 1114958003939 PAS domain; Region: PAS; smart00091 1114958003940 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114958003941 PAS domain; Region: PAS; smart00091 1114958003942 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1114958003943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958003944 dimer interface [polypeptide binding]; other site 1114958003945 phosphorylation site [posttranslational modification] 1114958003946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958003947 ATP binding site [chemical binding]; other site 1114958003948 Mg2+ binding site [ion binding]; other site 1114958003949 G-X-G motif; other site 1114958003950 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1114958003951 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1114958003952 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114958003953 DNA binding site [nucleotide binding] 1114958003954 active site 1114958003955 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1114958003956 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1114958003957 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1114958003958 Phosphotransferase enzyme family; Region: APH; pfam01636 1114958003959 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1114958003960 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1114958003961 putative active site [active] 1114958003962 catalytic triad [active] 1114958003963 putative dimer interface [polypeptide binding]; other site 1114958003964 transaminase; Reviewed; Region: PRK08068 1114958003965 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958003966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958003967 homodimer interface [polypeptide binding]; other site 1114958003968 catalytic residue [active] 1114958003969 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1114958003970 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1114958003971 dimer interface [polypeptide binding]; other site 1114958003972 active site 1114958003973 catalytic residue [active] 1114958003974 metal binding site [ion binding]; metal-binding site 1114958003975 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1114958003976 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958003977 motif II; other site 1114958003978 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 1114958003979 intersubunit interface [polypeptide binding]; other site 1114958003980 active site 1114958003981 Zn2+ binding site [ion binding]; other site 1114958003982 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1114958003983 Cupin domain; Region: Cupin_2; pfam07883 1114958003984 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1114958003985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958003986 dimer interface [polypeptide binding]; other site 1114958003987 phosphorylation site [posttranslational modification] 1114958003988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958003989 ATP binding site [chemical binding]; other site 1114958003990 Mg2+ binding site [ion binding]; other site 1114958003991 G-X-G motif; other site 1114958003992 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958003993 MarR family; Region: MarR; pfam01047 1114958003994 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1114958003995 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1114958003996 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114958003997 ligand binding site [chemical binding]; other site 1114958003998 flagellar motor protein MotA; Validated; Region: PRK08124 1114958003999 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114958004000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958004001 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114958004002 Walker A motif; other site 1114958004003 ATP binding site [chemical binding]; other site 1114958004004 Walker B motif; other site 1114958004005 arginine finger; other site 1114958004006 UvrB/uvrC motif; Region: UVR; pfam02151 1114958004007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958004008 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114958004009 Walker A motif; other site 1114958004010 ATP binding site [chemical binding]; other site 1114958004011 Walker B motif; other site 1114958004012 arginine finger; other site 1114958004013 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1114958004014 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1114958004015 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1114958004016 Ligand Binding Site [chemical binding]; other site 1114958004017 6-pyruvoyl tetrahydropterin synthase/QueD family protein; Region: 6PTHBS; TIGR00039 1114958004018 active site 1114958004019 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1114958004020 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1114958004021 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1114958004022 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1114958004023 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1114958004024 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1114958004025 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1114958004026 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1114958004027 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1114958004028 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1114958004029 catalytic residues [active] 1114958004030 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1114958004031 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114958004032 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1114958004033 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1114958004034 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1114958004035 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1114958004036 active site 1114958004037 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958004038 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958004039 DNA binding site [nucleotide binding] 1114958004040 domain linker motif; other site 1114958004041 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1114958004042 putative dimerization interface [polypeptide binding]; other site 1114958004043 putative ligand binding site [chemical binding]; other site 1114958004044 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1114958004045 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1114958004046 PRD domain; Region: PRD; pfam00874 1114958004047 PRD domain; Region: PRD; pfam00874 1114958004048 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1114958004049 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1114958004050 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114958004051 active site turn [active] 1114958004052 phosphorylation site [posttranslational modification] 1114958004053 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1114958004054 HPr interaction site; other site 1114958004055 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1114958004056 active site 1114958004057 phosphorylation site [posttranslational modification] 1114958004058 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1114958004059 dimerization domain swap beta strand [polypeptide binding]; other site 1114958004060 regulatory protein interface [polypeptide binding]; other site 1114958004061 active site 1114958004062 regulatory phosphorylation site [posttranslational modification]; other site 1114958004063 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1114958004064 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1114958004065 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1114958004066 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1114958004067 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1114958004068 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1114958004069 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958004070 FeS/SAM binding site; other site 1114958004071 Cache domain; Region: Cache_1; pfam02743 1114958004072 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958004073 dimerization interface [polypeptide binding]; other site 1114958004074 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958004075 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114958004076 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958004077 dimer interface [polypeptide binding]; other site 1114958004078 putative CheW interface [polypeptide binding]; other site 1114958004079 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1114958004080 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1114958004081 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1114958004082 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1114958004083 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1114958004084 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114958004085 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114958004086 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1114958004087 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114958004088 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958004089 putative active site [active] 1114958004090 heme pocket [chemical binding]; other site 1114958004091 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1114958004092 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958004093 putative active site [active] 1114958004094 heme pocket [chemical binding]; other site 1114958004095 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958004096 putative active site [active] 1114958004097 heme pocket [chemical binding]; other site 1114958004098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958004099 dimer interface [polypeptide binding]; other site 1114958004100 phosphorylation site [posttranslational modification] 1114958004101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958004102 ATP binding site [chemical binding]; other site 1114958004103 Mg2+ binding site [ion binding]; other site 1114958004104 G-X-G motif; other site 1114958004105 aminotransferase A; Validated; Region: PRK07683 1114958004106 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958004107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958004108 homodimer interface [polypeptide binding]; other site 1114958004109 catalytic residue [active] 1114958004110 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1114958004111 putative CheA interaction surface; other site 1114958004112 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958004113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958004114 active site 1114958004115 phosphorylation site [posttranslational modification] 1114958004116 intermolecular recognition site; other site 1114958004117 dimerization interface [polypeptide binding]; other site 1114958004118 YkyB-like protein; Region: YkyB; pfam14177 1114958004119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958004120 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114958004121 putative substrate translocation pore; other site 1114958004122 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958004123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1114958004124 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1114958004125 phosphodiesterase YaeI; Provisional; Region: PRK11340 1114958004126 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1114958004127 putative active site [active] 1114958004128 putative metal binding site [ion binding]; other site 1114958004129 short chain dehydrogenase; Provisional; Region: PRK07677 1114958004130 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1114958004131 NAD(P) binding site [chemical binding]; other site 1114958004132 substrate binding site [chemical binding]; other site 1114958004133 homotetramer interface [polypeptide binding]; other site 1114958004134 active site 1114958004135 homodimer interface [polypeptide binding]; other site 1114958004136 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1114958004137 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1114958004138 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1114958004139 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1114958004140 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1114958004141 FOG: CBS domain [General function prediction only]; Region: COG0517 1114958004142 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1114958004143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958004144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958004145 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958004146 dimerization interface [polypeptide binding]; other site 1114958004147 flavodoxin; Provisional; Region: PRK06703 1114958004148 BNR repeat-like domain; Region: BNR_2; pfam13088 1114958004149 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1114958004150 flavodoxin, short chain; Region: flav_short; TIGR01753 1114958004151 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1114958004152 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1114958004153 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1114958004154 active site 1114958004155 trimer interface [polypeptide binding]; other site 1114958004156 substrate binding site [chemical binding]; other site 1114958004157 CoA binding site [chemical binding]; other site 1114958004158 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1114958004159 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1114958004160 metal binding site [ion binding]; metal-binding site 1114958004161 hypothetical protein; Provisional; Region: PRK03094 1114958004162 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1114958004163 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1114958004164 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1114958004165 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1114958004166 catalytic residues [active] 1114958004167 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1114958004168 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1114958004169 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1114958004170 GTP binding site; other site 1114958004171 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1114958004172 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1114958004173 ATP binding site [chemical binding]; other site 1114958004174 substrate interface [chemical binding]; other site 1114958004175 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1114958004176 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1114958004177 dimer interface [polypeptide binding]; other site 1114958004178 putative functional site; other site 1114958004179 putative MPT binding site; other site 1114958004180 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1114958004181 Walker A motif; other site 1114958004182 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1114958004183 MoaE homodimer interface [polypeptide binding]; other site 1114958004184 MoaD interaction [polypeptide binding]; other site 1114958004185 active site residues [active] 1114958004186 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1114958004187 MoaE interaction surface [polypeptide binding]; other site 1114958004188 MoeB interaction surface [polypeptide binding]; other site 1114958004189 thiocarboxylated glycine; other site 1114958004190 Yip1 domain; Region: Yip1; pfam04893 1114958004191 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1114958004192 HlyD family secretion protein; Region: HlyD_3; pfam13437 1114958004193 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114958004194 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114958004195 Walker A/P-loop; other site 1114958004196 ATP binding site [chemical binding]; other site 1114958004197 Q-loop/lid; other site 1114958004198 ABC transporter signature motif; other site 1114958004199 Walker B; other site 1114958004200 D-loop; other site 1114958004201 H-loop/switch region; other site 1114958004202 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114958004203 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1114958004204 FtsX-like permease family; Region: FtsX; pfam02687 1114958004205 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114958004206 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1114958004207 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114958004208 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1114958004209 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1114958004210 putative substrate binding site [chemical binding]; other site 1114958004211 putative ATP binding site [chemical binding]; other site 1114958004212 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1114958004213 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114958004214 active site 1114958004215 phosphorylation site [posttranslational modification] 1114958004216 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1114958004217 active site 1114958004218 P-loop; other site 1114958004219 phosphorylation site [posttranslational modification] 1114958004220 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1114958004221 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1114958004222 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1114958004223 Catalytic site [active] 1114958004224 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1114958004225 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114958004226 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114958004227 ABC transporter; Region: ABC_tran_2; pfam12848 1114958004228 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114958004229 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1114958004230 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1114958004231 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1114958004232 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1114958004233 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1114958004234 rod-share determining protein MreBH; Provisional; Region: PRK13929 1114958004235 MreB and similar proteins; Region: MreB_like; cd10225 1114958004236 nucleotide binding site [chemical binding]; other site 1114958004237 Mg binding site [ion binding]; other site 1114958004238 putative protofilament interaction site [polypeptide binding]; other site 1114958004239 RodZ interaction site [polypeptide binding]; other site 1114958004240 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1114958004241 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1114958004242 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1114958004243 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1114958004244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958004245 putative active site [active] 1114958004246 heme pocket [chemical binding]; other site 1114958004247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958004248 dimer interface [polypeptide binding]; other site 1114958004249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958004250 ATP binding site [chemical binding]; other site 1114958004251 Mg2+ binding site [ion binding]; other site 1114958004252 G-X-G motif; other site 1114958004253 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1114958004254 putative active site pocket [active] 1114958004255 dimerization interface [polypeptide binding]; other site 1114958004256 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1114958004257 putative active site pocket [active] 1114958004258 dimerization interface [polypeptide binding]; other site 1114958004259 putative catalytic residue [active] 1114958004260 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1114958004261 TrkA-N domain; Region: TrkA_N; pfam02254 1114958004262 TrkA-C domain; Region: TrkA_C; pfam02080 1114958004263 adenine deaminase; Region: ade; TIGR01178 1114958004264 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958004265 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1114958004266 active site 1114958004267 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1114958004268 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1114958004269 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1114958004270 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1114958004271 hypothetical protein; Provisional; Region: PRK13667 1114958004272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958004273 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958004274 active site 1114958004275 motif I; other site 1114958004276 motif II; other site 1114958004277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958004278 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1114958004279 active site 1114958004280 catalytic residues [active] 1114958004281 metal binding site [ion binding]; metal-binding site 1114958004282 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1114958004283 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1114958004284 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114958004285 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1114958004286 FMN binding site [chemical binding]; other site 1114958004287 substrate binding site [chemical binding]; other site 1114958004288 putative catalytic residue [active] 1114958004289 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004290 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004291 active site 1114958004292 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004293 KR domain; Region: KR; pfam08659 1114958004294 putative NADP binding site [chemical binding]; other site 1114958004295 active site 1114958004296 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958004297 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004298 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004299 active site 1114958004300 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958004301 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004302 putative NADP binding site [chemical binding]; other site 1114958004303 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958004304 active site 1114958004305 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958004306 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958004307 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1114958004308 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004309 active site 1114958004310 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958004311 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004312 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958004313 putative NADP binding site [chemical binding]; other site 1114958004314 active site 1114958004315 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958004316 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004317 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004318 active site 1114958004319 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958004320 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004321 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958004322 putative NADP binding site [chemical binding]; other site 1114958004323 active site 1114958004324 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958004325 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004326 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004327 active site 1114958004328 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958004329 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004330 putative NADP binding site [chemical binding]; other site 1114958004331 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958004332 active site 1114958004333 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958004334 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004335 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1114958004336 active site 1114958004337 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958004338 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004339 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958004340 putative NADP binding site [chemical binding]; other site 1114958004341 active site 1114958004342 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958004343 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004344 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004345 active site 1114958004346 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004347 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958004348 putative NADP binding site [chemical binding]; other site 1114958004349 active site 1114958004350 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958004351 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004352 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004353 active site 1114958004354 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958004355 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958004356 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004357 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958004358 putative NADP binding site [chemical binding]; other site 1114958004359 active site 1114958004360 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004361 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004362 active site 1114958004363 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958004364 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004365 putative NADP binding site [chemical binding]; other site 1114958004366 KR domain; Region: KR; pfam08659 1114958004367 active site 1114958004368 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958004369 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004370 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004371 active site 1114958004372 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958004373 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004374 putative NADP binding site [chemical binding]; other site 1114958004375 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958004376 active site 1114958004377 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958004378 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958004379 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958004380 active site 1114958004381 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958004382 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958004383 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958004384 putative NADP binding site [chemical binding]; other site 1114958004385 KR domain; Region: KR; pfam08659 1114958004386 active site 1114958004387 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114958004388 Beta-lactamase; Region: Beta-lactamase; pfam00144 1114958004389 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114958004390 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1114958004391 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1114958004392 TPP-binding site [chemical binding]; other site 1114958004393 tetramer interface [polypeptide binding]; other site 1114958004394 heterodimer interface [polypeptide binding]; other site 1114958004395 phosphorylation loop region [posttranslational modification] 1114958004396 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1114958004397 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1114958004398 alpha subunit interface [polypeptide binding]; other site 1114958004399 TPP binding site [chemical binding]; other site 1114958004400 heterodimer interface [polypeptide binding]; other site 1114958004401 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114958004402 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1114958004403 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114958004404 E3 interaction surface; other site 1114958004405 lipoyl attachment site [posttranslational modification]; other site 1114958004406 e3 binding domain; Region: E3_binding; pfam02817 1114958004407 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1114958004408 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1114958004409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1114958004410 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958004411 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114958004412 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1114958004413 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1114958004414 NodB motif; other site 1114958004415 active site 1114958004416 catalytic site [active] 1114958004417 metal binding site [ion binding]; metal-binding site 1114958004418 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1114958004419 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1114958004420 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1114958004421 homodimer interface [polypeptide binding]; other site 1114958004422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958004423 catalytic residue [active] 1114958004424 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1114958004425 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 1114958004426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1114958004427 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1114958004428 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1114958004429 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1114958004430 active site 1114958004431 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1114958004432 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114958004433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958004434 Coenzyme A binding pocket [chemical binding]; other site 1114958004435 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1114958004436 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1114958004437 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1114958004438 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1114958004439 active site 1114958004440 Zn binding site [ion binding]; other site 1114958004441 Putative zinc-finger; Region: zf-HC2; pfam13490 1114958004442 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1114958004443 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1114958004444 G1 box; other site 1114958004445 putative GEF interaction site [polypeptide binding]; other site 1114958004446 GTP/Mg2+ binding site [chemical binding]; other site 1114958004447 Switch I region; other site 1114958004448 G2 box; other site 1114958004449 G3 box; other site 1114958004450 Switch II region; other site 1114958004451 G4 box; other site 1114958004452 G5 box; other site 1114958004453 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1114958004454 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1114958004455 YlaH-like protein; Region: YlaH; pfam14036 1114958004456 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 1114958004457 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1114958004458 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1114958004459 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1114958004460 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1114958004461 putative active site [active] 1114958004462 PhoH-like protein; Region: PhoH; pfam02562 1114958004463 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1114958004464 glutaminase A; Region: Gln_ase; TIGR03814 1114958004465 hypothetical protein; Provisional; Region: PRK13666 1114958004466 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1114958004467 pyruvate carboxylase; Reviewed; Region: PRK12999 1114958004468 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958004469 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1114958004470 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1114958004471 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1114958004472 active site 1114958004473 catalytic residues [active] 1114958004474 metal binding site [ion binding]; metal-binding site 1114958004475 homodimer binding site [polypeptide binding]; other site 1114958004476 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114958004477 carboxyltransferase (CT) interaction site; other site 1114958004478 biotinylation site [posttranslational modification]; other site 1114958004479 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1114958004480 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1114958004481 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1114958004482 UbiA prenyltransferase family; Region: UbiA; pfam01040 1114958004483 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1114958004484 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1114958004485 Cytochrome c; Region: Cytochrom_C; pfam00034 1114958004486 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1114958004487 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1114958004488 D-pathway; other site 1114958004489 Putative ubiquinol binding site [chemical binding]; other site 1114958004490 Low-spin heme (heme b) binding site [chemical binding]; other site 1114958004491 Putative water exit pathway; other site 1114958004492 Binuclear center (heme o3/CuB) [ion binding]; other site 1114958004493 K-pathway; other site 1114958004494 Putative proton exit pathway; other site 1114958004495 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1114958004496 Subunit I/III interface [polypeptide binding]; other site 1114958004497 Subunit III/IV interface [polypeptide binding]; other site 1114958004498 cytochrome c oxidase, subunit IVB; Region: CoxD_Bacillus; TIGR02908 1114958004499 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1114958004500 YugN-like family; Region: YugN; pfam08868 1114958004501 FOG: CBS domain [General function prediction only]; Region: COG0517 1114958004502 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1114958004503 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1114958004504 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1114958004505 Putative coat protein; Region: YlbD_coat; pfam14071 1114958004506 YlbE-like protein; Region: YlbE; pfam14003 1114958004507 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1114958004508 hypothetical protein; Provisional; Region: PRK02886 1114958004509 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1114958004510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958004511 S-adenosylmethionine binding site [chemical binding]; other site 1114958004512 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1114958004513 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1114958004514 active site 1114958004515 (T/H)XGH motif; other site 1114958004516 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1114958004517 Nucleoside recognition; Region: Gate; pfam07670 1114958004518 Nucleoside recognition; Region: Gate; pfam07670 1114958004519 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1114958004520 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1114958004521 active site 1114958004522 nucleophile elbow; other site 1114958004523 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1114958004524 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1114958004525 protein binding site [polypeptide binding]; other site 1114958004526 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1114958004527 hypothetical protein; Provisional; Region: PRK13670 1114958004528 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1114958004529 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1114958004530 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1114958004531 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1114958004532 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1114958004533 hypothetical protein; Provisional; Region: PRK13688 1114958004534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958004535 Coenzyme A binding pocket [chemical binding]; other site 1114958004536 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1114958004537 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1114958004538 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1114958004539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1114958004540 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 1114958004541 mraZ protein; Region: TIGR00242 1114958004542 MraZ protein; Region: MraZ; pfam02381 1114958004543 MraZ protein; Region: MraZ; pfam02381 1114958004544 MraW methylase family; Region: Methyltransf_5; pfam01795 1114958004545 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1114958004546 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1114958004547 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1114958004548 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114958004549 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1114958004550 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1114958004551 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1114958004552 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1114958004553 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114958004554 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1114958004555 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1114958004556 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1114958004557 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114958004558 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114958004559 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114958004560 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1114958004561 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1114958004562 Mg++ binding site [ion binding]; other site 1114958004563 putative catalytic motif [active] 1114958004564 putative substrate binding site [chemical binding]; other site 1114958004565 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1114958004566 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114958004567 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114958004568 stage V sporulation protein E; Region: spoVE; TIGR02615 1114958004569 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1114958004570 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1114958004571 active site 1114958004572 homodimer interface [polypeptide binding]; other site 1114958004573 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1114958004574 FAD binding domain; Region: FAD_binding_4; pfam01565 1114958004575 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1114958004576 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1114958004577 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1114958004578 Cell division protein FtsQ; Region: FtsQ; pfam03799 1114958004579 cell division protein FtsA; Region: ftsA; TIGR01174 1114958004580 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1114958004581 nucleotide binding site [chemical binding]; other site 1114958004582 Cell division protein FtsA; Region: FtsA; pfam14450 1114958004583 cell division protein FtsZ; Validated; Region: PRK09330 1114958004584 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1114958004585 nucleotide binding site [chemical binding]; other site 1114958004586 SulA interaction site; other site 1114958004587 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1114958004588 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1114958004589 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1114958004590 active site 1114958004591 catalytic triad [active] 1114958004592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1114958004593 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1114958004594 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1114958004595 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1114958004596 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1114958004597 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1114958004598 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1114958004599 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958004600 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958004601 DNA binding residues [nucleotide binding] 1114958004602 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1114958004603 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958004604 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114958004605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958004606 DNA binding residues [nucleotide binding] 1114958004607 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114958004608 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1114958004609 Walker A/P-loop; other site 1114958004610 ATP binding site [chemical binding]; other site 1114958004611 Q-loop/lid; other site 1114958004612 ABC transporter signature motif; other site 1114958004613 Walker B; other site 1114958004614 D-loop; other site 1114958004615 H-loop/switch region; other site 1114958004616 acetylornithine deacetylase; Validated; Region: PRK08596 1114958004617 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1114958004618 metal binding site [ion binding]; metal-binding site 1114958004619 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1114958004620 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1114958004621 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1114958004622 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1114958004623 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114958004624 catalytic residue [active] 1114958004625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1114958004626 YGGT family; Region: YGGT; pfam02325 1114958004627 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1114958004628 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958004629 RNA binding surface [nucleotide binding]; other site 1114958004630 DivIVA protein; Region: DivIVA; pfam05103 1114958004631 DivIVA domain; Region: DivI1A_domain; TIGR03544 1114958004632 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1114958004633 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1114958004634 HIGH motif; other site 1114958004635 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1114958004636 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1114958004637 active site 1114958004638 KMSKS motif; other site 1114958004639 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1114958004640 tRNA binding surface [nucleotide binding]; other site 1114958004641 anticodon binding site; other site 1114958004642 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1114958004643 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1114958004644 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1114958004645 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958004646 RNA binding surface [nucleotide binding]; other site 1114958004647 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1114958004648 active site 1114958004649 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1114958004650 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958004651 active site 1114958004652 uracil-xanthine permease; Region: ncs2; TIGR00801 1114958004653 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1114958004654 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1114958004655 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1114958004656 dihydroorotase; Validated; Region: pyrC; PRK09357 1114958004657 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958004658 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1114958004659 active site 1114958004660 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1114958004661 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1114958004662 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1114958004663 catalytic site [active] 1114958004664 subunit interface [polypeptide binding]; other site 1114958004665 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1114958004666 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958004667 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1114958004668 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1114958004669 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958004670 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1114958004671 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1114958004672 IMP binding site; other site 1114958004673 dimer interface [polypeptide binding]; other site 1114958004674 interdomain contacts; other site 1114958004675 partial ornithine binding site; other site 1114958004676 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1114958004677 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1114958004678 FAD binding pocket [chemical binding]; other site 1114958004679 FAD binding motif [chemical binding]; other site 1114958004680 phosphate binding motif [ion binding]; other site 1114958004681 beta-alpha-beta structure motif; other site 1114958004682 NAD binding pocket [chemical binding]; other site 1114958004683 Iron coordination center [ion binding]; other site 1114958004684 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1114958004685 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1114958004686 heterodimer interface [polypeptide binding]; other site 1114958004687 active site 1114958004688 FMN binding site [chemical binding]; other site 1114958004689 homodimer interface [polypeptide binding]; other site 1114958004690 substrate binding site [chemical binding]; other site 1114958004691 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1114958004692 active site 1114958004693 dimer interface [polypeptide binding]; other site 1114958004694 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958004695 active site 1114958004696 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1114958004697 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1114958004698 Active Sites [active] 1114958004699 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1114958004700 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1114958004701 ATP-sulfurylase; Region: ATPS; cd00517 1114958004702 active site 1114958004703 HXXH motif; other site 1114958004704 flexible loop; other site 1114958004705 AAA domain; Region: AAA_33; pfam13671 1114958004706 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1114958004707 ligand-binding site [chemical binding]; other site 1114958004708 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1114958004709 diphthine synthase; Region: dph5; TIGR00522 1114958004710 active site 1114958004711 SAM binding site [chemical binding]; other site 1114958004712 homodimer interface [polypeptide binding]; other site 1114958004713 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1114958004714 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1114958004715 putative active site [active] 1114958004716 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1114958004717 putative active site [active] 1114958004718 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1114958004719 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1114958004720 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1114958004721 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1114958004722 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1114958004723 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1114958004724 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114958004725 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1114958004726 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958004727 motif II; other site 1114958004728 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1114958004729 hypothetical protein; Provisional; Region: PRK11820 1114958004730 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1114958004731 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1114958004732 hypothetical protein; Provisional; Region: PRK04323 1114958004733 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1114958004734 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1114958004735 catalytic site [active] 1114958004736 G-X2-G-X-G-K; other site 1114958004737 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1114958004738 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1114958004739 Flavoprotein; Region: Flavoprotein; pfam02441 1114958004740 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1114958004741 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1114958004742 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958004743 ATP binding site [chemical binding]; other site 1114958004744 putative Mg++ binding site [ion binding]; other site 1114958004745 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958004746 nucleotide binding region [chemical binding]; other site 1114958004747 ATP-binding site [chemical binding]; other site 1114958004748 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1114958004749 active site 1114958004750 catalytic residues [active] 1114958004751 metal binding site [ion binding]; metal-binding site 1114958004752 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1114958004753 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1114958004754 putative active site [active] 1114958004755 substrate binding site [chemical binding]; other site 1114958004756 putative cosubstrate binding site; other site 1114958004757 catalytic site [active] 1114958004758 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1114958004759 substrate binding site [chemical binding]; other site 1114958004760 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1114958004761 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1114958004762 putative RNA binding site [nucleotide binding]; other site 1114958004763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958004764 S-adenosylmethionine binding site [chemical binding]; other site 1114958004765 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1114958004766 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958004767 FeS/SAM binding site; other site 1114958004768 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1114958004769 Protein phosphatase 2C; Region: PP2C; pfam00481 1114958004770 active site 1114958004771 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1114958004772 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1114958004773 active site 1114958004774 ATP binding site [chemical binding]; other site 1114958004775 substrate binding site [chemical binding]; other site 1114958004776 activation loop (A-loop); other site 1114958004777 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1114958004778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1114958004779 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1114958004780 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1114958004781 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1114958004782 GTPase RsgA; Reviewed; Region: PRK00098 1114958004783 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1114958004784 RNA binding site [nucleotide binding]; other site 1114958004785 homodimer interface [polypeptide binding]; other site 1114958004786 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1114958004787 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1114958004788 GTP/Mg2+ binding site [chemical binding]; other site 1114958004789 G4 box; other site 1114958004790 G5 box; other site 1114958004791 G1 box; other site 1114958004792 Switch I region; other site 1114958004793 G2 box; other site 1114958004794 G3 box; other site 1114958004795 Switch II region; other site 1114958004796 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1114958004797 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1114958004798 substrate binding site [chemical binding]; other site 1114958004799 hexamer interface [polypeptide binding]; other site 1114958004800 metal binding site [ion binding]; metal-binding site 1114958004801 Thiamine pyrophosphokinase; Region: TPK; cd07995 1114958004802 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1114958004803 active site 1114958004804 dimerization interface [polypeptide binding]; other site 1114958004805 thiamine binding site [chemical binding]; other site 1114958004806 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 1114958004807 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1114958004808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1114958004809 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1114958004810 DAK2 domain; Region: Dak2; pfam02734 1114958004811 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1114958004812 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1114958004813 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1114958004814 putative L-serine binding site [chemical binding]; other site 1114958004815 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1114958004816 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1114958004817 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1114958004818 Y-family of DNA polymerases; Region: PolY; cl12025 1114958004819 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1114958004820 generic binding surface II; other site 1114958004821 ssDNA binding site; other site 1114958004822 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958004823 ATP binding site [chemical binding]; other site 1114958004824 putative Mg++ binding site [ion binding]; other site 1114958004825 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958004826 nucleotide binding region [chemical binding]; other site 1114958004827 ATP-binding site [chemical binding]; other site 1114958004828 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1114958004829 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1114958004830 putative phosphate acyltransferase; Provisional; Region: PRK05331 1114958004831 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1114958004832 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114958004833 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1114958004834 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1114958004835 NAD(P) binding site [chemical binding]; other site 1114958004836 homotetramer interface [polypeptide binding]; other site 1114958004837 homodimer interface [polypeptide binding]; other site 1114958004838 active site 1114958004839 acyl carrier protein; Provisional; Region: acpP; PRK00982 1114958004840 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1114958004841 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1114958004842 dimerization interface [polypeptide binding]; other site 1114958004843 active site 1114958004844 metal binding site [ion binding]; metal-binding site 1114958004845 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1114958004846 dsRNA binding site [nucleotide binding]; other site 1114958004847 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1114958004848 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1114958004849 Walker A/P-loop; other site 1114958004850 ATP binding site [chemical binding]; other site 1114958004851 Q-loop/lid; other site 1114958004852 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1114958004853 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1114958004854 ABC transporter signature motif; other site 1114958004855 Walker B; other site 1114958004856 D-loop; other site 1114958004857 H-loop/switch region; other site 1114958004858 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1114958004859 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1114958004860 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1114958004861 GTP binding site [chemical binding]; other site 1114958004862 Phosphotransferase enzyme family; Region: APH; pfam01636 1114958004863 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1114958004864 active site 1114958004865 substrate binding site [chemical binding]; other site 1114958004866 ATP binding site [chemical binding]; other site 1114958004867 putative DNA-binding protein; Validated; Region: PRK00118 1114958004868 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1114958004869 signal recognition particle protein; Provisional; Region: PRK10867 1114958004870 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1114958004871 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1114958004872 P loop; other site 1114958004873 GTP binding site [chemical binding]; other site 1114958004874 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1114958004875 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1114958004876 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1114958004877 KH domain; Region: KH_4; pfam13083 1114958004878 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1114958004879 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1114958004880 RimM N-terminal domain; Region: RimM; pfam01782 1114958004881 PRC-barrel domain; Region: PRC; pfam05239 1114958004882 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1114958004883 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1114958004884 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1114958004885 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1114958004886 GTP/Mg2+ binding site [chemical binding]; other site 1114958004887 G4 box; other site 1114958004888 G5 box; other site 1114958004889 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1114958004890 G1 box; other site 1114958004891 G1 box; other site 1114958004892 GTP/Mg2+ binding site [chemical binding]; other site 1114958004893 Switch I region; other site 1114958004894 G2 box; other site 1114958004895 G2 box; other site 1114958004896 G3 box; other site 1114958004897 G3 box; other site 1114958004898 Switch II region; other site 1114958004899 Switch II region; other site 1114958004900 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1114958004901 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114958004902 active site 1114958004903 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1114958004904 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1114958004905 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1114958004906 CoA-ligase; Region: Ligase_CoA; pfam00549 1114958004907 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1114958004908 CoA binding domain; Region: CoA_binding; smart00881 1114958004909 CoA-ligase; Region: Ligase_CoA; pfam00549 1114958004910 DNA protecting protein DprA; Region: dprA; TIGR00732 1114958004911 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1114958004912 DNA topoisomerase I; Validated; Region: PRK05582 1114958004913 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1114958004914 active site 1114958004915 interdomain interaction site; other site 1114958004916 putative metal-binding site [ion binding]; other site 1114958004917 nucleotide binding site [chemical binding]; other site 1114958004918 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1114958004919 domain I; other site 1114958004920 DNA binding groove [nucleotide binding] 1114958004921 phosphate binding site [ion binding]; other site 1114958004922 domain II; other site 1114958004923 domain III; other site 1114958004924 nucleotide binding site [chemical binding]; other site 1114958004925 catalytic site [active] 1114958004926 domain IV; other site 1114958004927 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1114958004928 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1114958004929 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1114958004930 Glucose inhibited division protein A; Region: GIDA; pfam01134 1114958004931 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1114958004932 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1114958004933 active site 1114958004934 Int/Topo IB signature motif; other site 1114958004935 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1114958004936 active site 1114958004937 HslU subunit interaction site [polypeptide binding]; other site 1114958004938 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1114958004939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958004940 Walker A motif; other site 1114958004941 ATP binding site [chemical binding]; other site 1114958004942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1114958004943 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1114958004944 transcriptional repressor CodY; Validated; Region: PRK04158 1114958004945 CodY GAF-like domain; Region: CodY; pfam06018 1114958004946 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1114958004947 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1114958004948 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1114958004949 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1114958004950 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1114958004951 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1114958004952 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1114958004953 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 1114958004954 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1114958004955 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1114958004956 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1114958004957 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1114958004958 MgtE intracellular N domain; Region: MgtE_N; smart00924 1114958004959 FliG C-terminal domain; Region: FliG_C; pfam01706 1114958004960 flagellar assembly protein H; Validated; Region: fliH; PRK06669 1114958004961 Flagellar assembly protein FliH; Region: FliH; pfam02108 1114958004962 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1114958004963 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1114958004964 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1114958004965 Walker A motif/ATP binding site; other site 1114958004966 Walker B motif; other site 1114958004967 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1114958004968 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1114958004969 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1114958004970 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1114958004971 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1114958004972 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1114958004973 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1114958004974 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1114958004975 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1114958004976 Flagellar protein (FlbD); Region: FlbD; pfam06289 1114958004977 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1114958004978 Flagellar basal body-associated protein [Cell motility and secretion]; Region: FliL; COG1580 1114958004979 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1114958004980 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1114958004981 flagellar motor switch protein; Validated; Region: PRK08119 1114958004982 CheC-like family; Region: CheC; pfam04509 1114958004983 CheC-like family; Region: CheC; pfam04509 1114958004984 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1114958004985 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958004986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958004987 active site 1114958004988 phosphorylation site [posttranslational modification] 1114958004989 intermolecular recognition site; other site 1114958004990 dimerization interface [polypeptide binding]; other site 1114958004991 flagella biosynthesis protein FliZ; Provisional; Region: PRK13415 1114958004992 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1114958004993 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1114958004994 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1114958004995 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1114958004996 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1114958004997 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1114958004998 FHIPEP family; Region: FHIPEP; pfam00771 1114958004999 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1114958005000 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1114958005001 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1114958005002 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1114958005003 P-loop; other site 1114958005004 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1114958005005 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1114958005006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958005007 active site 1114958005008 phosphorylation site [posttranslational modification] 1114958005009 intermolecular recognition site; other site 1114958005010 dimerization interface [polypeptide binding]; other site 1114958005011 CheB methylesterase; Region: CheB_methylest; pfam01339 1114958005012 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1114958005013 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1114958005014 putative binding surface; other site 1114958005015 active site 1114958005016 P2 response regulator binding domain; Region: P2; pfam07194 1114958005017 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1114958005018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958005019 ATP binding site [chemical binding]; other site 1114958005020 Mg2+ binding site [ion binding]; other site 1114958005021 G-X-G motif; other site 1114958005022 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1114958005023 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1114958005024 putative CheA interaction surface; other site 1114958005025 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1114958005026 CheC-like family; Region: CheC; pfam04509 1114958005027 CheC-like family; Region: CheC; pfam04509 1114958005028 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1114958005029 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1114958005030 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958005031 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114958005032 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958005033 DNA binding residues [nucleotide binding] 1114958005034 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1114958005035 rRNA interaction site [nucleotide binding]; other site 1114958005036 S8 interaction site; other site 1114958005037 putative laminin-1 binding site; other site 1114958005038 elongation factor Ts; Provisional; Region: tsf; PRK09377 1114958005039 UBA/TS-N domain; Region: UBA; pfam00627 1114958005040 Elongation factor TS; Region: EF_TS; pfam00889 1114958005041 Elongation factor TS; Region: EF_TS; pfam00889 1114958005042 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1114958005043 putative nucleotide binding site [chemical binding]; other site 1114958005044 uridine monophosphate binding site [chemical binding]; other site 1114958005045 homohexameric interface [polypeptide binding]; other site 1114958005046 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1114958005047 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1114958005048 hinge region; other site 1114958005049 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1114958005050 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1114958005051 catalytic residue [active] 1114958005052 putative FPP diphosphate binding site; other site 1114958005053 putative FPP binding hydrophobic cleft; other site 1114958005054 dimer interface [polypeptide binding]; other site 1114958005055 putative IPP diphosphate binding site; other site 1114958005056 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1114958005057 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1114958005058 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1114958005059 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1114958005060 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1114958005061 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1114958005062 RIP metalloprotease RseP; Region: TIGR00054 1114958005063 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1114958005064 active site 1114958005065 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1114958005066 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1114958005067 protein binding site [polypeptide binding]; other site 1114958005068 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1114958005069 putative substrate binding region [chemical binding]; other site 1114958005070 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1114958005071 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1114958005072 dimer interface [polypeptide binding]; other site 1114958005073 motif 1; other site 1114958005074 active site 1114958005075 motif 2; other site 1114958005076 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1114958005077 putative deacylase active site [active] 1114958005078 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1114958005079 active site 1114958005080 motif 3; other site 1114958005081 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1114958005082 anticodon binding site; other site 1114958005083 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1114958005084 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1114958005085 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1114958005086 generic binding surface II; other site 1114958005087 generic binding surface I; other site 1114958005088 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1114958005089 active site 1114958005090 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1114958005091 active site 1114958005092 catalytic site [active] 1114958005093 substrate binding site [chemical binding]; other site 1114958005094 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1114958005095 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1114958005096 Sm and related proteins; Region: Sm_like; cl00259 1114958005097 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1114958005098 putative oligomer interface [polypeptide binding]; other site 1114958005099 putative RNA binding site [nucleotide binding]; other site 1114958005100 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1114958005101 NusA N-terminal domain; Region: NusA_N; pfam08529 1114958005102 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1114958005103 RNA binding site [nucleotide binding]; other site 1114958005104 homodimer interface [polypeptide binding]; other site 1114958005105 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1114958005106 G-X-X-G motif; other site 1114958005107 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1114958005108 G-X-X-G motif; other site 1114958005109 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1114958005110 putative RNA binding cleft [nucleotide binding]; other site 1114958005111 hypothetical protein; Provisional; Region: PRK07714 1114958005112 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1114958005113 translation initiation factor IF-2; Region: IF-2; TIGR00487 1114958005114 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1114958005115 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1114958005116 G1 box; other site 1114958005117 putative GEF interaction site [polypeptide binding]; other site 1114958005118 GTP/Mg2+ binding site [chemical binding]; other site 1114958005119 Switch I region; other site 1114958005120 G2 box; other site 1114958005121 G3 box; other site 1114958005122 Switch II region; other site 1114958005123 G4 box; other site 1114958005124 G5 box; other site 1114958005125 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1114958005126 Translation-initiation factor 2; Region: IF-2; pfam11987 1114958005127 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1114958005128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1114958005129 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1114958005130 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1114958005131 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1114958005132 RNA binding site [nucleotide binding]; other site 1114958005133 active site 1114958005134 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1114958005135 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1114958005136 active site 1114958005137 Riboflavin kinase; Region: Flavokinase; smart00904 1114958005138 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1114958005139 16S/18S rRNA binding site [nucleotide binding]; other site 1114958005140 S13e-L30e interaction site [polypeptide binding]; other site 1114958005141 25S rRNA binding site [nucleotide binding]; other site 1114958005142 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1114958005143 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1114958005144 RNase E interface [polypeptide binding]; other site 1114958005145 trimer interface [polypeptide binding]; other site 1114958005146 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1114958005147 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1114958005148 RNase E interface [polypeptide binding]; other site 1114958005149 trimer interface [polypeptide binding]; other site 1114958005150 active site 1114958005151 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1114958005152 putative nucleic acid binding region [nucleotide binding]; other site 1114958005153 G-X-X-G motif; other site 1114958005154 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1114958005155 RNA binding site [nucleotide binding]; other site 1114958005156 domain interface; other site 1114958005157 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1114958005158 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1114958005159 NodB motif; other site 1114958005160 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114958005161 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1114958005162 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114958005163 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1114958005164 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1114958005165 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1114958005166 NAD binding site [chemical binding]; other site 1114958005167 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1114958005168 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1114958005169 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1114958005170 aspartate kinase I; Reviewed; Region: PRK08210 1114958005171 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1114958005172 putative catalytic residues [active] 1114958005173 putative nucleotide binding site [chemical binding]; other site 1114958005174 putative aspartate binding site [chemical binding]; other site 1114958005175 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1114958005176 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1114958005177 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1114958005178 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1114958005179 dimer interface [polypeptide binding]; other site 1114958005180 active site 1114958005181 catalytic residue [active] 1114958005182 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1114958005183 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114958005184 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1114958005185 Clp protease; Region: CLP_protease; pfam00574 1114958005186 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1114958005187 active site 1114958005188 YlzJ-like protein; Region: YlzJ; pfam14035 1114958005189 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1114958005190 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1114958005191 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1114958005192 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1114958005193 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1114958005194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958005195 DNA-binding site [nucleotide binding]; DNA binding site 1114958005196 UTRA domain; Region: UTRA; pfam07702 1114958005197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958005198 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958005199 putative substrate translocation pore; other site 1114958005200 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958005201 MarR family; Region: MarR_2; pfam12802 1114958005202 MMPL family; Region: MMPL; pfam03176 1114958005203 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1114958005204 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114958005205 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114958005206 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1114958005207 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1114958005208 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1114958005209 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1114958005210 classical (c) SDRs; Region: SDR_c; cd05233 1114958005211 NAD(P) binding site [chemical binding]; other site 1114958005212 active site 1114958005213 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1114958005214 ACT domain; Region: ACT; pfam01842 1114958005215 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1114958005216 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1114958005217 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958005218 non-specific DNA binding site [nucleotide binding]; other site 1114958005219 salt bridge; other site 1114958005220 sequence-specific DNA binding site [nucleotide binding]; other site 1114958005221 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1114958005222 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1114958005223 competence damage-inducible protein A; Provisional; Region: PRK00549 1114958005224 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1114958005225 putative MPT binding site; other site 1114958005226 Competence-damaged protein; Region: CinA; pfam02464 1114958005227 recombinase A; Provisional; Region: recA; PRK09354 1114958005228 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1114958005229 hexamer interface [polypeptide binding]; other site 1114958005230 Walker A motif; other site 1114958005231 ATP binding site [chemical binding]; other site 1114958005232 Walker B motif; other site 1114958005233 Beta-lactamase; Region: Beta-lactamase; pfam00144 1114958005234 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1114958005235 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1114958005236 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1114958005237 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114958005238 Zn2+ binding site [ion binding]; other site 1114958005239 Mg2+ binding site [ion binding]; other site 1114958005240 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1114958005241 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114958005242 putative active site [active] 1114958005243 metal binding site [ion binding]; metal-binding site 1114958005244 homodimer binding site [polypeptide binding]; other site 1114958005245 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1114958005246 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114958005247 NAD(P) binding site [chemical binding]; other site 1114958005248 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114958005249 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1114958005250 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1114958005251 substrate-cofactor binding pocket; other site 1114958005252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958005253 catalytic residue [active] 1114958005254 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1114958005255 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1114958005256 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958005257 FeS/SAM binding site; other site 1114958005258 TRAM domain; Region: TRAM; pfam01938 1114958005259 Predicted membrane protein [Function unknown]; Region: COG4550 1114958005260 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1114958005261 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1114958005262 MutS domain I; Region: MutS_I; pfam01624 1114958005263 MutS domain II; Region: MutS_II; pfam05188 1114958005264 MutS domain III; Region: MutS_III; pfam05192 1114958005265 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1114958005266 Walker A/P-loop; other site 1114958005267 ATP binding site [chemical binding]; other site 1114958005268 Q-loop/lid; other site 1114958005269 ABC transporter signature motif; other site 1114958005270 Walker B; other site 1114958005271 D-loop; other site 1114958005272 H-loop/switch region; other site 1114958005273 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1114958005274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958005275 ATP binding site [chemical binding]; other site 1114958005276 Mg2+ binding site [ion binding]; other site 1114958005277 G-X-G motif; other site 1114958005278 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1114958005279 ATP binding site [chemical binding]; other site 1114958005280 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1114958005281 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958005282 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1114958005283 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114958005284 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114958005285 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1114958005286 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1114958005287 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114958005288 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1114958005289 FMN binding site [chemical binding]; other site 1114958005290 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1114958005291 substrate binding site [chemical binding]; other site 1114958005292 putative catalytic residue [active] 1114958005293 acyl carrier protein; Validated; Region: PRK07117 1114958005294 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1114958005295 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1114958005296 dimer interface [polypeptide binding]; other site 1114958005297 active site 1114958005298 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958005299 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1114958005300 substrate binding site [chemical binding]; other site 1114958005301 oxyanion hole (OAH) forming residues; other site 1114958005302 trimer interface [polypeptide binding]; other site 1114958005303 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1114958005304 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958005305 substrate binding site [chemical binding]; other site 1114958005306 oxyanion hole (OAH) forming residues; other site 1114958005307 trimer interface [polypeptide binding]; other site 1114958005308 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 1114958005309 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1114958005310 acyl-activating enzyme (AAE) consensus motif; other site 1114958005311 putative AMP binding site [chemical binding]; other site 1114958005312 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005313 Condensation domain; Region: Condensation; pfam00668 1114958005314 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005315 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005316 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1114958005317 acyl-activating enzyme (AAE) consensus motif; other site 1114958005318 AMP binding site [chemical binding]; other site 1114958005319 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005320 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005321 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005322 active site 1114958005323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958005324 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005325 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005326 KR domain; Region: KR; pfam08659 1114958005327 putative NADP binding site [chemical binding]; other site 1114958005328 active site 1114958005329 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005330 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958005331 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005332 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005333 active site 1114958005334 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005335 putative NADP binding site [chemical binding]; other site 1114958005336 active site 1114958005337 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005338 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005339 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005340 active site 1114958005341 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005342 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005343 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005344 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005345 active site 1114958005346 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005347 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005348 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958005349 putative NADP binding site [chemical binding]; other site 1114958005350 active site 1114958005351 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958005352 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005353 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005354 active site 1114958005355 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958005356 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958005357 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005358 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005359 active site 1114958005360 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005361 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958005362 putative NADP binding site [chemical binding]; other site 1114958005363 active site 1114958005364 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005365 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005366 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005367 active site 1114958005368 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005369 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005370 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005371 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005372 active site 1114958005373 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005374 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005375 putative NADP binding site [chemical binding]; other site 1114958005376 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958005377 active site 1114958005378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958005379 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005380 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005381 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005382 active site 1114958005383 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005384 putative NADP binding site [chemical binding]; other site 1114958005385 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958005386 active site 1114958005387 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005388 Condensation domain; Region: Condensation; pfam00668 1114958005389 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005390 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005391 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005392 acyl-activating enzyme (AAE) consensus motif; other site 1114958005393 AMP binding site [chemical binding]; other site 1114958005394 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005395 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005396 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005397 active site 1114958005398 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005399 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005400 putative NADP binding site [chemical binding]; other site 1114958005401 KR domain; Region: KR; pfam08659 1114958005402 active site 1114958005403 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958005404 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005405 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005406 active site 1114958005407 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005408 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005409 putative NADP binding site [chemical binding]; other site 1114958005410 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958005411 active site 1114958005412 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958005413 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958005414 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005415 active site 1114958005416 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958005417 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958005418 putative NADP binding site [chemical binding]; other site 1114958005419 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958005420 active site 1114958005421 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1114958005422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958005423 S-adenosylmethionine binding site [chemical binding]; other site 1114958005424 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958005425 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005426 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005427 active site 1114958005428 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958005429 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1114958005430 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005431 active site 1114958005432 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005433 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1114958005434 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1114958005435 Cytochrome P450; Region: p450; cl12078 1114958005436 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1114958005437 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1114958005438 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1114958005439 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1114958005440 active site 1114958005441 catalytic triad [active] 1114958005442 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1114958005443 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 1114958005444 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1114958005445 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1114958005446 YmaF family; Region: YmaF; pfam12788 1114958005447 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1114958005448 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1114958005449 bacterial Hfq-like; Region: Hfq; cd01716 1114958005450 hexamer interface [polypeptide binding]; other site 1114958005451 Sm1 motif; other site 1114958005452 RNA binding site [nucleotide binding]; other site 1114958005453 Sm2 motif; other site 1114958005454 YmzC-like protein; Region: YmzC; pfam14157 1114958005455 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1114958005456 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1114958005457 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1114958005458 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1114958005459 active site 1114958005460 dimer interface [polypeptide binding]; other site 1114958005461 catalytic residues [active] 1114958005462 effector binding site; other site 1114958005463 R2 peptide binding site; other site 1114958005464 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1114958005465 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1114958005466 dimer interface [polypeptide binding]; other site 1114958005467 putative radical transfer pathway; other site 1114958005468 diiron center [ion binding]; other site 1114958005469 tyrosyl radical; other site 1114958005470 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 1114958005471 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1114958005472 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1114958005473 active site 1114958005474 metal binding site [ion binding]; metal-binding site 1114958005475 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1114958005476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958005477 Walker A motif; other site 1114958005478 ATP binding site [chemical binding]; other site 1114958005479 Walker B motif; other site 1114958005480 arginine finger; other site 1114958005481 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1114958005482 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1114958005483 HflX GTPase family; Region: HflX; cd01878 1114958005484 G1 box; other site 1114958005485 GTP/Mg2+ binding site [chemical binding]; other site 1114958005486 Switch I region; other site 1114958005487 G2 box; other site 1114958005488 G3 box; other site 1114958005489 Switch II region; other site 1114958005490 G4 box; other site 1114958005491 G5 box; other site 1114958005492 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1114958005493 Aluminium resistance protein; Region: Alum_res; pfam06838 1114958005494 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1114958005495 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114958005496 DNA binding residues [nucleotide binding] 1114958005497 glutamine synthetase, type I; Region: GlnA; TIGR00653 1114958005498 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1114958005499 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1114958005500 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1114958005501 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1114958005502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958005503 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1114958005504 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1114958005505 inhibitor binding site; inhibition site 1114958005506 active site 1114958005507 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1114958005508 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1114958005509 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1114958005510 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1114958005511 nucleotide binding site [chemical binding]; other site 1114958005512 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1114958005513 xylose isomerase; Provisional; Region: PRK05474 1114958005514 xylose isomerase; Region: xylose_isom_A; TIGR02630 1114958005515 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1114958005516 N- and C-terminal domain interface [polypeptide binding]; other site 1114958005517 D-xylulose kinase; Region: XylB; TIGR01312 1114958005518 active site 1114958005519 MgATP binding site [chemical binding]; other site 1114958005520 catalytic site [active] 1114958005521 metal binding site [ion binding]; metal-binding site 1114958005522 xylulose binding site [chemical binding]; other site 1114958005523 homodimer interface [polypeptide binding]; other site 1114958005524 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1114958005525 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1114958005526 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 1114958005527 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1114958005528 Predicted transcriptional regulator [Transcription]; Region: COG2378 1114958005529 HTH domain; Region: HTH_11; pfam08279 1114958005530 WYL domain; Region: WYL; pfam13280 1114958005531 DinB family; Region: DinB; cl17821 1114958005532 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1114958005533 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1114958005534 NAD binding site [chemical binding]; other site 1114958005535 substrate binding site [chemical binding]; other site 1114958005536 catalytic Zn binding site [ion binding]; other site 1114958005537 tetramer interface [polypeptide binding]; other site 1114958005538 structural Zn binding site [ion binding]; other site 1114958005539 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1114958005540 Coenzyme A binding pocket [chemical binding]; other site 1114958005541 YoaP-like; Region: YoaP; pfam14268 1114958005542 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1114958005543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114958005544 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1114958005545 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1114958005546 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1114958005547 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1114958005548 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1114958005549 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1114958005550 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1114958005551 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1114958005552 trimer interface [polypeptide binding]; other site 1114958005553 active site 1114958005554 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1114958005555 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 1114958005556 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1114958005557 LexA repressor; Validated; Region: PRK00215 1114958005558 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958005559 putative DNA binding site [nucleotide binding]; other site 1114958005560 putative Zn2+ binding site [ion binding]; other site 1114958005561 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1114958005562 Catalytic site [active] 1114958005563 cell division suppressor protein YneA; Provisional; Region: PRK14125 1114958005564 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958005565 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1114958005566 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1114958005567 catalytic residues [active] 1114958005568 catalytic nucleophile [active] 1114958005569 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1114958005570 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1114958005571 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1114958005572 TPP-binding site [chemical binding]; other site 1114958005573 dimer interface [polypeptide binding]; other site 1114958005574 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1114958005575 PYR/PP interface [polypeptide binding]; other site 1114958005576 dimer interface [polypeptide binding]; other site 1114958005577 TPP binding site [chemical binding]; other site 1114958005578 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114958005579 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1114958005580 hypothetical protein; Provisional; Region: PRK01844 1114958005581 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1114958005582 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1114958005583 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1114958005584 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958005585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958005586 active site 1114958005587 phosphorylation site [posttranslational modification] 1114958005588 intermolecular recognition site; other site 1114958005589 dimerization interface [polypeptide binding]; other site 1114958005590 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1114958005591 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1114958005592 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1114958005593 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1114958005594 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 1114958005595 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 1114958005596 aconitate hydratase; Validated; Region: PRK09277 1114958005597 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1114958005598 substrate binding site [chemical binding]; other site 1114958005599 ligand binding site [chemical binding]; other site 1114958005600 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1114958005601 substrate binding site [chemical binding]; other site 1114958005602 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1114958005603 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1114958005604 catalytic residues [active] 1114958005605 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1114958005606 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 1114958005607 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1114958005608 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114958005609 active site 1114958005610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1114958005611 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1114958005612 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1114958005613 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1114958005614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958005615 ATP binding site [chemical binding]; other site 1114958005616 Mg2+ binding site [ion binding]; other site 1114958005617 G-X-G motif; other site 1114958005618 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1114958005619 anchoring element; other site 1114958005620 dimer interface [polypeptide binding]; other site 1114958005621 ATP binding site [chemical binding]; other site 1114958005622 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1114958005623 active site 1114958005624 metal binding site [ion binding]; metal-binding site 1114958005625 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1114958005626 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1114958005627 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1114958005628 CAP-like domain; other site 1114958005629 active site 1114958005630 primary dimer interface [polypeptide binding]; other site 1114958005631 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958005632 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958005633 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958005634 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1114958005635 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1114958005636 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1114958005637 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114958005638 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114958005639 substrate binding site [chemical binding]; other site 1114958005640 ATP binding site [chemical binding]; other site 1114958005641 putative oxidoreductase; Provisional; Region: PRK10083 1114958005642 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1114958005643 putative NAD(P) binding site [chemical binding]; other site 1114958005644 catalytic Zn binding site [ion binding]; other site 1114958005645 structural Zn binding site [ion binding]; other site 1114958005646 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1114958005647 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1114958005648 active site 1114958005649 intersubunit interface [polypeptide binding]; other site 1114958005650 catalytic residue [active] 1114958005651 mannonate dehydratase; Provisional; Region: PRK03906 1114958005652 mannonate dehydratase; Region: uxuA; TIGR00695 1114958005653 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1114958005654 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1114958005655 putative NAD(P) binding site [chemical binding]; other site 1114958005656 active site 1114958005657 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958005658 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958005659 DNA binding site [nucleotide binding] 1114958005660 domain linker motif; other site 1114958005661 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1114958005662 putative dimerization interface [polypeptide binding]; other site 1114958005663 putative ligand binding site [chemical binding]; other site 1114958005664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958005665 D-galactonate transporter; Region: 2A0114; TIGR00893 1114958005666 putative substrate translocation pore; other site 1114958005667 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1114958005668 YndJ-like protein; Region: YndJ; pfam14158 1114958005669 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1114958005670 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1114958005671 Cellulose binding domain; Region: CBM_3; pfam00942 1114958005672 Tic20-like protein; Region: Tic20; pfam09685 1114958005673 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958005674 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1114958005675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958005676 dimer interface [polypeptide binding]; other site 1114958005677 phosphorylation site [posttranslational modification] 1114958005678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958005679 ATP binding site [chemical binding]; other site 1114958005680 Mg2+ binding site [ion binding]; other site 1114958005681 G-X-G motif; other site 1114958005682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958005683 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958005684 active site 1114958005685 phosphorylation site [posttranslational modification] 1114958005686 intermolecular recognition site; other site 1114958005687 dimerization interface [polypeptide binding]; other site 1114958005688 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958005689 DNA binding site [nucleotide binding] 1114958005690 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1114958005691 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1114958005692 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1114958005693 substrate binding site [chemical binding]; other site 1114958005694 active site 1114958005695 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1114958005696 metal binding site [ion binding]; metal-binding site 1114958005697 ligand binding site [chemical binding]; other site 1114958005698 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005699 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1114958005700 acyl-activating enzyme (AAE) consensus motif; other site 1114958005701 AMP binding site [chemical binding]; other site 1114958005702 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005703 Condensation domain; Region: Condensation; pfam00668 1114958005704 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005705 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005706 Condensation domain; Region: Condensation; pfam00668 1114958005707 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005708 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005709 acyl-activating enzyme (AAE) consensus motif; other site 1114958005710 AMP binding site [chemical binding]; other site 1114958005711 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005712 Thioesterase domain; Region: Thioesterase; pfam00975 1114958005713 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005714 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005715 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005716 acyl-activating enzyme (AAE) consensus motif; other site 1114958005717 AMP binding site [chemical binding]; other site 1114958005718 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005719 Condensation domain; Region: Condensation; pfam00668 1114958005720 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005721 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005722 Condensation domain; Region: Condensation; pfam00668 1114958005723 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005724 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005725 acyl-activating enzyme (AAE) consensus motif; other site 1114958005726 AMP binding site [chemical binding]; other site 1114958005727 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005728 Condensation domain; Region: Condensation; pfam00668 1114958005729 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005730 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005731 Condensation domain; Region: Condensation; pfam00668 1114958005732 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005733 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005734 acyl-activating enzyme (AAE) consensus motif; other site 1114958005735 AMP binding site [chemical binding]; other site 1114958005736 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005737 Condensation domain; Region: Condensation; pfam00668 1114958005738 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005739 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005740 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005741 acyl-activating enzyme (AAE) consensus motif; other site 1114958005742 AMP binding site [chemical binding]; other site 1114958005743 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005744 Condensation domain; Region: Condensation; pfam00668 1114958005745 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005746 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005747 Condensation domain; Region: Condensation; pfam00668 1114958005748 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005749 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005750 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005751 acyl-activating enzyme (AAE) consensus motif; other site 1114958005752 AMP binding site [chemical binding]; other site 1114958005753 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005754 Condensation domain; Region: Condensation; pfam00668 1114958005755 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005756 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005757 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 1114958005758 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1114958005759 acyl-activating enzyme (AAE) consensus motif; other site 1114958005760 putative AMP binding site [chemical binding]; other site 1114958005761 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005762 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958005763 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958005764 active site 1114958005765 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005766 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1114958005767 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958005768 inhibitor-cofactor binding pocket; inhibition site 1114958005769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958005770 catalytic residue [active] 1114958005771 Condensation domain; Region: Condensation; pfam00668 1114958005772 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005773 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005774 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005775 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1114958005776 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114958005777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958005778 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1114958005779 NAD(P) binding site [chemical binding]; other site 1114958005780 active site 1114958005781 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1114958005782 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1114958005783 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1114958005784 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1114958005785 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1114958005786 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1114958005787 Cytochrome P450; Region: p450; cl12078 1114958005788 biotin synthase; Validated; Region: PRK06256 1114958005789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958005790 FeS/SAM binding site; other site 1114958005791 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1114958005792 AAA domain; Region: AAA_26; pfam13500 1114958005793 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1114958005794 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1114958005795 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1114958005796 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1114958005797 substrate-cofactor binding pocket; other site 1114958005798 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958005799 catalytic residue [active] 1114958005800 6-carboxyhexanoate--CoA ligase; Provisional; Region: PRK01322 1114958005801 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1114958005802 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958005803 inhibitor-cofactor binding pocket; inhibition site 1114958005804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958005805 catalytic residue [active] 1114958005806 Predicted membrane protein [Function unknown]; Region: COG2246 1114958005807 GtrA-like protein; Region: GtrA; pfam04138 1114958005808 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1114958005809 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1114958005810 active site 1114958005811 tetramer interface; other site 1114958005812 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1114958005813 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1114958005814 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1114958005815 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1114958005816 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1114958005817 enoyl-CoA hydratase; Provisional; Region: PRK07657 1114958005818 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958005819 substrate binding site [chemical binding]; other site 1114958005820 oxyanion hole (OAH) forming residues; other site 1114958005821 trimer interface [polypeptide binding]; other site 1114958005822 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1114958005823 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1114958005824 active site 1114958005825 catalytic residues [active] 1114958005826 metal binding site [ion binding]; metal-binding site 1114958005827 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114958005828 carboxyltransferase (CT) interaction site; other site 1114958005829 biotinylation site [posttranslational modification]; other site 1114958005830 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1114958005831 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958005832 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1114958005833 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1114958005834 AMP-binding domain protein; Validated; Region: PRK08315 1114958005835 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114958005836 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1114958005837 acyl-activating enzyme (AAE) consensus motif; other site 1114958005838 putative AMP binding site [chemical binding]; other site 1114958005839 putative active site [active] 1114958005840 putative CoA binding site [chemical binding]; other site 1114958005841 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114958005842 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1114958005843 FAD binding site [chemical binding]; other site 1114958005844 homotetramer interface [polypeptide binding]; other site 1114958005845 substrate binding pocket [chemical binding]; other site 1114958005846 catalytic base [active] 1114958005847 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1114958005848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1114958005849 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1114958005850 Condensation domain; Region: Condensation; pfam00668 1114958005851 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005852 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1114958005853 acyl-activating enzyme (AAE) consensus motif; other site 1114958005854 AMP binding site [chemical binding]; other site 1114958005855 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005856 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1114958005857 Condensation domain; Region: Condensation; pfam00668 1114958005858 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005859 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005860 acyl-activating enzyme (AAE) consensus motif; other site 1114958005861 AMP binding site [chemical binding]; other site 1114958005862 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005863 Condensation domain; Region: Condensation; pfam00668 1114958005864 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005865 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005866 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005867 acyl-activating enzyme (AAE) consensus motif; other site 1114958005868 AMP binding site [chemical binding]; other site 1114958005869 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005870 Condensation domain; Region: Condensation; pfam00668 1114958005871 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005872 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005873 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005874 acyl-activating enzyme (AAE) consensus motif; other site 1114958005875 AMP binding site [chemical binding]; other site 1114958005876 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005877 Condensation domain; Region: Condensation; pfam00668 1114958005878 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005879 Condensation domain; Region: Condensation; pfam00668 1114958005880 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005881 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005882 acyl-activating enzyme (AAE) consensus motif; other site 1114958005883 AMP binding site [chemical binding]; other site 1114958005884 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005885 Condensation domain; Region: Condensation; pfam00668 1114958005886 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005887 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005888 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1114958005889 acyl-activating enzyme (AAE) consensus motif; other site 1114958005890 AMP binding site [chemical binding]; other site 1114958005891 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005892 Condensation domain; Region: Condensation; pfam00668 1114958005893 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005894 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1114958005895 CoA binding site [chemical binding]; other site 1114958005896 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005897 Condensation domain; Region: Condensation; pfam00668 1114958005898 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005899 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005900 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005901 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005902 acyl-activating enzyme (AAE) consensus motif; other site 1114958005903 AMP binding site [chemical binding]; other site 1114958005904 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005905 Condensation domain; Region: Condensation; pfam00668 1114958005906 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005907 Condensation domain; Region: Condensation; pfam00668 1114958005908 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005909 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005910 acyl-activating enzyme (AAE) consensus motif; other site 1114958005911 AMP binding site [chemical binding]; other site 1114958005912 Condensation domain; Region: Condensation; pfam00668 1114958005913 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005914 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005915 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005916 acyl-activating enzyme (AAE) consensus motif; other site 1114958005917 AMP binding site [chemical binding]; other site 1114958005918 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005919 Condensation domain; Region: Condensation; pfam00668 1114958005920 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005921 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958005922 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958005923 acyl-activating enzyme (AAE) consensus motif; other site 1114958005924 AMP binding site [chemical binding]; other site 1114958005925 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958005926 Condensation domain; Region: Condensation; pfam00668 1114958005927 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1114958005928 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1114958005929 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 1114958005930 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1114958005931 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1114958005932 active site 1114958005933 catalytic residues [active] 1114958005934 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1114958005935 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1114958005936 LXG domain of WXG superfamily; Region: LXG; pfam04740 1114958005937 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 1114958005938 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114958005939 amidase catalytic site [active] 1114958005940 substrate binding site [chemical binding]; other site 1114958005941 Zn binding residues [ion binding]; other site 1114958005942 Bacterial SH3 domain; Region: SH3_3; pfam08239 1114958005943 holin, SPP1 family; Region: holin_SPP1; TIGR01592 1114958005944 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 1114958005945 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 1114958005946 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1114958005947 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1114958005948 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1114958005949 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1114958005950 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1114958005951 Phage tail protein; Region: Sipho_tail; pfam05709 1114958005952 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1114958005953 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114958005954 catalytic residue [active] 1114958005955 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1114958005956 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1114958005957 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1114958005958 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1114958005959 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1114958005960 oligomerization interface [polypeptide binding]; other site 1114958005961 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1114958005962 Phage capsid family; Region: Phage_capsid; pfam05065 1114958005963 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1114958005964 Phage-related protein [Function unknown]; Region: COG4695 1114958005965 Phage portal protein; Region: Phage_portal; pfam04860 1114958005966 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1114958005967 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1114958005968 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1114958005969 Int/Topo IB signature motif; other site 1114958005970 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1114958005971 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 1114958005972 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1114958005973 Helix-turn-helix domain; Region: HTH_17; cl17695 1114958005974 hypothetical protein; Validated; Region: PRK08116 1114958005975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958005976 Walker A motif; other site 1114958005977 ATP binding site [chemical binding]; other site 1114958005978 Walker B motif; other site 1114958005979 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 1114958005980 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 1114958005981 Domain of unknown function (DUF771); Region: DUF771; cl09962 1114958005982 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958005983 non-specific DNA binding site [nucleotide binding]; other site 1114958005984 salt bridge; other site 1114958005985 sequence-specific DNA binding site [nucleotide binding]; other site 1114958005986 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114958005987 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958005988 sequence-specific DNA binding site [nucleotide binding]; other site 1114958005989 salt bridge; other site 1114958005990 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958005991 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1114958005992 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1114958005993 Int/Topo IB signature motif; other site 1114958005994 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1114958005995 Int/Topo IB signature motif; other site 1114958005996 Helix-turn-helix domain; Region: HTH_17; cl17695 1114958005997 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1114958005998 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1114958005999 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114958006000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958006001 putative substrate translocation pore; other site 1114958006002 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958006003 dimerization interface [polypeptide binding]; other site 1114958006004 putative DNA binding site [nucleotide binding]; other site 1114958006005 putative Zn2+ binding site [ion binding]; other site 1114958006006 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1114958006007 anticodon binding site; other site 1114958006008 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958006009 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958006010 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1114958006011 putative dimerization interface [polypeptide binding]; other site 1114958006012 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1114958006013 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1114958006014 NAD(P) binding site [chemical binding]; other site 1114958006015 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1114958006016 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114958006017 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1114958006018 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1114958006019 active site 1114958006020 dimer interface [polypeptide binding]; other site 1114958006021 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1114958006022 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1114958006023 active site 1114958006024 FMN binding site [chemical binding]; other site 1114958006025 substrate binding site [chemical binding]; other site 1114958006026 3Fe-4S cluster binding site [ion binding]; other site 1114958006027 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1114958006028 domain interface; other site 1114958006029 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958006030 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958006031 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1114958006032 putative dimerization interface [polypeptide binding]; other site 1114958006033 gamma-glutamyl kinase; Provisional; Region: PRK13402 1114958006034 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1114958006035 nucleotide binding site [chemical binding]; other site 1114958006036 homotetrameric interface [polypeptide binding]; other site 1114958006037 putative phosphate binding site [ion binding]; other site 1114958006038 putative allosteric binding site; other site 1114958006039 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1114958006040 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1114958006041 Replication terminator protein; Region: RTP; pfam02334 1114958006042 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1114958006043 classical (c) SDRs; Region: SDR_c; cd05233 1114958006044 NAD(P) binding site [chemical binding]; other site 1114958006045 active site 1114958006046 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1114958006047 polyol permease family; Region: 2A0118; TIGR00897 1114958006048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958006049 putative substrate translocation pore; other site 1114958006050 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1114958006051 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1114958006052 nucleotide binding site [chemical binding]; other site 1114958006053 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1114958006054 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1114958006055 putative ligand binding site [chemical binding]; other site 1114958006056 putative NAD binding site [chemical binding]; other site 1114958006057 catalytic site [active] 1114958006058 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1114958006059 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1114958006060 putative [4Fe-4S] binding site [ion binding]; other site 1114958006061 putative molybdopterin cofactor binding site [chemical binding]; other site 1114958006062 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1114958006063 putative molybdopterin cofactor binding site; other site 1114958006064 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1114958006065 MarR family; Region: MarR_2; pfam12802 1114958006066 short chain dehydrogenase; Provisional; Region: PRK06500 1114958006067 classical (c) SDRs; Region: SDR_c; cd05233 1114958006068 NAD(P) binding site [chemical binding]; other site 1114958006069 active site 1114958006070 Predicted transcriptional regulators [Transcription]; Region: COG1733 1114958006071 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1114958006072 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1114958006073 dimer interface [polypeptide binding]; other site 1114958006074 putative tRNA-binding site [nucleotide binding]; other site 1114958006075 Cupin domain; Region: Cupin_2; pfam07883 1114958006076 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958006077 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114958006078 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958006079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958006080 WHG domain; Region: WHG; pfam13305 1114958006081 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114958006082 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958006083 dimerization interface [polypeptide binding]; other site 1114958006084 putative DNA binding site [nucleotide binding]; other site 1114958006085 putative Zn2+ binding site [ion binding]; other site 1114958006086 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1114958006087 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114958006088 catalytic residue [active] 1114958006089 Predicted membrane protein [Function unknown]; Region: COG2322 1114958006090 Protein required for attachment to host cells; Region: Host_attach; cl02398 1114958006091 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1114958006092 putative dimer interface [polypeptide binding]; other site 1114958006093 catalytic triad [active] 1114958006094 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958006095 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958006096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1114958006097 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1114958006098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958006099 ATP binding site [chemical binding]; other site 1114958006100 putative Mg++ binding site [ion binding]; other site 1114958006101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958006102 nucleotide binding region [chemical binding]; other site 1114958006103 ATP-binding site [chemical binding]; other site 1114958006104 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1114958006105 HRDC domain; Region: HRDC; pfam00570 1114958006106 azoreductase; Provisional; Region: PRK13556 1114958006107 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1114958006108 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1114958006109 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1114958006110 putative dimer interface [polypeptide binding]; other site 1114958006111 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1114958006112 pentamer interface [polypeptide binding]; other site 1114958006113 dodecaamer interface [polypeptide binding]; other site 1114958006114 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114958006115 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1114958006116 NAD(P) binding site [chemical binding]; other site 1114958006117 catalytic residues [active] 1114958006118 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1114958006119 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 1114958006120 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1114958006121 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1114958006122 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1114958006123 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1114958006124 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1114958006125 Na2 binding site [ion binding]; other site 1114958006126 putative substrate binding site 1 [chemical binding]; other site 1114958006127 Na binding site 1 [ion binding]; other site 1114958006128 putative substrate binding site 2 [chemical binding]; other site 1114958006129 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1114958006130 Sodium Bile acid symporter family; Region: SBF; pfam01758 1114958006131 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114958006132 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1114958006133 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114958006134 E3 interaction surface; other site 1114958006135 lipoyl attachment site [posttranslational modification]; other site 1114958006136 e3 binding domain; Region: E3_binding; pfam02817 1114958006137 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1114958006138 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1114958006139 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1114958006140 TPP-binding site [chemical binding]; other site 1114958006141 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1114958006142 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1114958006143 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1114958006144 metal ion-dependent adhesion site (MIDAS); other site 1114958006145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958006146 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1114958006147 Walker A motif; other site 1114958006148 ATP binding site [chemical binding]; other site 1114958006149 Walker B motif; other site 1114958006150 arginine finger; other site 1114958006151 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1114958006152 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1114958006153 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1114958006154 E-class dimer interface [polypeptide binding]; other site 1114958006155 P-class dimer interface [polypeptide binding]; other site 1114958006156 active site 1114958006157 Cu2+ binding site [ion binding]; other site 1114958006158 Zn2+ binding site [ion binding]; other site 1114958006159 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958006160 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1114958006161 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958006162 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1114958006163 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958006164 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1114958006165 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958006166 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1114958006167 NlpC/P60 family; Region: NLPC_P60; pfam00877 1114958006168 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1114958006169 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1114958006170 active site 1114958006171 TDP-binding site; other site 1114958006172 acceptor substrate-binding pocket; other site 1114958006173 homodimer interface [polypeptide binding]; other site 1114958006174 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1114958006175 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1114958006176 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1114958006177 multidrug efflux protein; Reviewed; Region: PRK01766 1114958006178 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1114958006179 cation binding site [ion binding]; other site 1114958006180 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1114958006181 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 1114958006182 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1114958006183 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1114958006184 EamA-like transporter family; Region: EamA; pfam00892 1114958006185 EamA-like transporter family; Region: EamA; pfam00892 1114958006186 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1114958006187 Predicted transcriptional regulators [Transcription]; Region: COG1733 1114958006188 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958006189 dimerization interface [polypeptide binding]; other site 1114958006190 putative DNA binding site [nucleotide binding]; other site 1114958006191 putative Zn2+ binding site [ion binding]; other site 1114958006192 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1114958006193 dimer interface [polypeptide binding]; other site 1114958006194 FMN binding site [chemical binding]; other site 1114958006195 Predicted esterase [General function prediction only]; Region: COG0400 1114958006196 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1114958006197 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958006198 Zn binding site [ion binding]; other site 1114958006199 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1114958006200 Zn binding site [ion binding]; other site 1114958006201 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1114958006202 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1114958006203 Na binding site [ion binding]; other site 1114958006204 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1114958006205 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1114958006206 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1114958006207 beta-galactosidase; Region: BGL; TIGR03356 1114958006208 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1114958006209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958006210 DNA-binding site [nucleotide binding]; DNA binding site 1114958006211 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1114958006212 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1114958006213 C-terminal peptidase (prc); Region: prc; TIGR00225 1114958006214 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1114958006215 protein binding site [polypeptide binding]; other site 1114958006216 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1114958006217 Catalytic dyad [active] 1114958006218 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1114958006219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958006220 S-adenosylmethionine binding site [chemical binding]; other site 1114958006221 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1114958006222 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1114958006223 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1114958006224 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1114958006225 YodL-like; Region: YodL; pfam14191 1114958006226 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1114958006227 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1114958006228 active site 1114958006229 YozD-like protein; Region: YozD; pfam14162 1114958006230 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1114958006231 hypothetical protein; Provisional; Region: PRK13672 1114958006232 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1114958006233 Zn binding site [ion binding]; other site 1114958006234 toxin interface [polypeptide binding]; other site 1114958006235 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1114958006236 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958006237 FeS/SAM binding site; other site 1114958006238 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1114958006239 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1114958006240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958006241 Coenzyme A binding pocket [chemical binding]; other site 1114958006242 acetylornithine deacetylase; Validated; Region: PRK06915 1114958006243 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1114958006244 metal binding site [ion binding]; metal-binding site 1114958006245 dimer interface [polypeptide binding]; other site 1114958006246 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1114958006247 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1114958006248 hypothetical protein; Provisional; Region: PRK06917 1114958006249 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958006250 inhibitor-cofactor binding pocket; inhibition site 1114958006251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958006252 catalytic residue [active] 1114958006253 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1114958006254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958006255 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114958006256 Coenzyme A binding pocket [chemical binding]; other site 1114958006257 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1114958006258 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958006259 active site 1114958006260 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1114958006261 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1114958006262 Phytase; Region: Phytase; pfam02333 1114958006263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006264 NAD(P) binding site [chemical binding]; other site 1114958006265 active site 1114958006266 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 1114958006267 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 1114958006268 YoqO-like protein; Region: YoqO; pfam14037 1114958006269 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958006270 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958006271 binding surface 1114958006272 TPR motif; other site 1114958006273 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958006274 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 1114958006275 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1114958006276 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1114958006277 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1114958006278 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1114958006279 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 1114958006280 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1114958006281 Staphylococcal nuclease homologues; Region: SNc; smart00318 1114958006282 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1114958006283 Catalytic site; other site 1114958006284 Excalibur calcium-binding domain; Region: Excalibur; smart00894 1114958006285 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1114958006286 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1114958006287 catalytic residues [active] 1114958006288 catalytic nucleophile [active] 1114958006289 Recombinase; Region: Recombinase; pfam07508 1114958006290 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1114958006291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006292 active site 1114958006293 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1114958006294 SelR domain; Region: SelR; pfam01641 1114958006295 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1114958006296 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958006297 MarR family; Region: MarR; pfam01047 1114958006298 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 1114958006299 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1114958006300 active site 1114958006301 catalytic triad [active] 1114958006302 oxyanion hole [active] 1114958006303 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1114958006304 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1114958006305 Cu(I) binding site [ion binding]; other site 1114958006306 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1114958006307 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1114958006308 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1114958006309 putative Ile/Val binding site [chemical binding]; other site 1114958006310 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1114958006311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958006312 catalytic residue [active] 1114958006313 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1114958006314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958006315 Walker A motif; other site 1114958006316 ATP binding site [chemical binding]; other site 1114958006317 Walker B motif; other site 1114958006318 arginine finger; other site 1114958006319 Haemolysin-III related; Region: HlyIII; cl03831 1114958006320 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1114958006321 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1114958006322 putative acyl-acceptor binding pocket; other site 1114958006323 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1114958006324 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1114958006325 folate binding site [chemical binding]; other site 1114958006326 NADP+ binding site [chemical binding]; other site 1114958006327 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1114958006328 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1114958006329 dimerization interface [polypeptide binding]; other site 1114958006330 active site 1114958006331 YpjP-like protein; Region: YpjP; pfam14005 1114958006332 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1114958006333 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1114958006334 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1114958006335 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1114958006336 Virulence factor; Region: Virulence_fact; pfam13769 1114958006337 HEAT repeats; Region: HEAT_2; pfam13646 1114958006338 HEAT repeats; Region: HEAT_2; pfam13646 1114958006339 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1114958006340 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1114958006341 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114958006342 Zn2+ binding site [ion binding]; other site 1114958006343 Mg2+ binding site [ion binding]; other site 1114958006344 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1114958006345 catalytic residues [active] 1114958006346 dimer interface [polypeptide binding]; other site 1114958006347 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1114958006348 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1114958006349 proposed active site lysine [active] 1114958006350 conserved cys residue [active] 1114958006351 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1114958006352 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1114958006353 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114958006354 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1114958006355 DNA-binding site [nucleotide binding]; DNA binding site 1114958006356 RNA-binding motif; other site 1114958006357 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1114958006358 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1114958006359 hypothetical protein; Validated; Region: PRK07708 1114958006360 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1114958006361 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114958006362 active site 1114958006363 conserved hypothetical integral membrane protein; Region: TIGR00697 1114958006364 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1114958006365 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114958006366 active site 1114958006367 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1114958006368 5'-3' exonuclease; Region: 53EXOc; smart00475 1114958006369 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1114958006370 active site 1114958006371 metal binding site 1 [ion binding]; metal-binding site 1114958006372 putative 5' ssDNA interaction site; other site 1114958006373 metal binding site 3; metal-binding site 1114958006374 metal binding site 2 [ion binding]; metal-binding site 1114958006375 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1114958006376 putative DNA binding site [nucleotide binding]; other site 1114958006377 putative metal binding site [ion binding]; other site 1114958006378 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1114958006379 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1114958006380 Dynamin family; Region: Dynamin_N; pfam00350 1114958006381 G1 box; other site 1114958006382 GTP/Mg2+ binding site [chemical binding]; other site 1114958006383 G2 box; other site 1114958006384 Switch I region; other site 1114958006385 G3 box; other site 1114958006386 Switch II region; other site 1114958006387 G4 box; other site 1114958006388 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1114958006389 G1 box; other site 1114958006390 GTP/Mg2+ binding site [chemical binding]; other site 1114958006391 Dynamin family; Region: Dynamin_N; pfam00350 1114958006392 G2 box; other site 1114958006393 Switch I region; other site 1114958006394 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1114958006395 G3 box; other site 1114958006396 Switch II region; other site 1114958006397 GTP/Mg2+ binding site [chemical binding]; other site 1114958006398 G4 box; other site 1114958006399 G5 box; other site 1114958006400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1114958006401 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1114958006402 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1114958006403 malonyl-CoA binding site [chemical binding]; other site 1114958006404 dimer interface [polypeptide binding]; other site 1114958006405 active site 1114958006406 product binding site; other site 1114958006407 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1114958006408 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114958006409 DNA binding site [nucleotide binding] 1114958006410 active site 1114958006411 Protein of unknown function (DUF421); Region: DUF421; cl00990 1114958006412 Protein of unknown function (DUF421); Region: DUF421; cl00990 1114958006413 Isochorismatase family; Region: Isochorismatase; pfam00857 1114958006414 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1114958006415 catalytic triad [active] 1114958006416 conserved cis-peptide bond; other site 1114958006417 xanthine permease; Region: pbuX; TIGR03173 1114958006418 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958006419 active site 1114958006420 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1114958006421 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1114958006422 active site 1114958006423 Zn binding site [ion binding]; other site 1114958006424 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1114958006425 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1114958006426 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1114958006427 YpzG-like protein; Region: YpzG; pfam14139 1114958006428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1114958006429 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1114958006430 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1114958006431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1114958006432 cell division protein GpsB; Provisional; Region: PRK14127 1114958006433 DivIVA domain; Region: DivI1A_domain; TIGR03544 1114958006434 hypothetical protein; Provisional; Region: PRK13660 1114958006435 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 1114958006436 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1114958006437 RNase_H superfamily; Region: RNase_H_2; pfam13482 1114958006438 active site 1114958006439 substrate binding site [chemical binding]; other site 1114958006440 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1114958006441 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958006442 ATP binding site [chemical binding]; other site 1114958006443 putative Mg++ binding site [ion binding]; other site 1114958006444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958006445 nucleotide binding region [chemical binding]; other site 1114958006446 ATP-binding site [chemical binding]; other site 1114958006447 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1114958006448 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1114958006449 HPr interaction site; other site 1114958006450 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1114958006451 active site 1114958006452 phosphorylation site [posttranslational modification] 1114958006453 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1114958006454 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 1114958006455 YppG-like protein; Region: YppG; pfam14179 1114958006456 YppF-like protein; Region: YppF; pfam14178 1114958006457 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1114958006458 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1114958006459 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1114958006460 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1114958006461 Transglycosylase; Region: Transgly; pfam00912 1114958006462 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1114958006463 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1114958006464 Interdomain contacts; other site 1114958006465 Cytokine receptor motif; other site 1114958006466 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1114958006467 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1114958006468 minor groove reading motif; other site 1114958006469 helix-hairpin-helix signature motif; other site 1114958006470 substrate binding pocket [chemical binding]; other site 1114958006471 active site 1114958006472 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1114958006473 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1114958006474 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1114958006475 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1114958006476 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1114958006477 putative dimer interface [polypeptide binding]; other site 1114958006478 putative anticodon binding site; other site 1114958006479 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1114958006480 homodimer interface [polypeptide binding]; other site 1114958006481 motif 1; other site 1114958006482 motif 2; other site 1114958006483 active site 1114958006484 motif 3; other site 1114958006485 aspartate aminotransferase; Provisional; Region: PRK05764 1114958006486 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958006487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958006488 homodimer interface [polypeptide binding]; other site 1114958006489 catalytic residue [active] 1114958006490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1114958006491 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1114958006492 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1114958006493 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1114958006494 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1114958006495 active site 1114958006496 catalytic site [active] 1114958006497 substrate binding site [chemical binding]; other site 1114958006498 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1114958006499 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1114958006500 tetramerization interface [polypeptide binding]; other site 1114958006501 active site 1114958006502 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1114958006503 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1114958006504 active site 1114958006505 ATP-binding site [chemical binding]; other site 1114958006506 pantoate-binding site; other site 1114958006507 HXXH motif; other site 1114958006508 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1114958006509 oligomerization interface [polypeptide binding]; other site 1114958006510 active site 1114958006511 metal binding site [ion binding]; metal-binding site 1114958006512 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1114958006513 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1114958006514 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1114958006515 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1114958006516 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1114958006517 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1114958006518 active site 1114958006519 NTP binding site [chemical binding]; other site 1114958006520 metal binding triad [ion binding]; metal-binding site 1114958006521 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1114958006522 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1114958006523 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1114958006524 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1114958006525 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1114958006526 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1114958006527 active site 1114958006528 dimer interfaces [polypeptide binding]; other site 1114958006529 catalytic residues [active] 1114958006530 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1114958006531 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1114958006532 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1114958006533 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1114958006534 homodimer interface [polypeptide binding]; other site 1114958006535 metal binding site [ion binding]; metal-binding site 1114958006536 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958006537 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958006538 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958006539 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1114958006540 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1114958006541 Cupin; Region: Cupin_1; smart00835 1114958006542 Cupin; Region: Cupin_1; smart00835 1114958006543 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 1114958006544 Predicted membrane protein [Function unknown]; Region: COG4347 1114958006545 Qo binding site; other site 1114958006546 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1114958006547 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1114958006548 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1114958006549 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1114958006550 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1114958006551 interchain domain interface [polypeptide binding]; other site 1114958006552 intrachain domain interface; other site 1114958006553 heme bH binding site [chemical binding]; other site 1114958006554 Qi binding site; other site 1114958006555 heme bL binding site [chemical binding]; other site 1114958006556 Qo binding site; other site 1114958006557 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1114958006558 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1114958006559 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1114958006560 iron-sulfur cluster [ion binding]; other site 1114958006561 [2Fe-2S] cluster binding site [ion binding]; other site 1114958006562 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1114958006563 hypothetical protein; Provisional; Region: PRK03636 1114958006564 UPF0302 domain; Region: UPF0302; pfam08864 1114958006565 A short protein domain of unknown function; Region: IDEAL; smart00914 1114958006566 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1114958006567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958006568 TPR motif; other site 1114958006569 binding surface 1114958006570 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1114958006571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958006572 binding surface 1114958006573 TPR motif; other site 1114958006574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958006575 binding surface 1114958006576 TPR motif; other site 1114958006577 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1114958006578 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1114958006579 hinge; other site 1114958006580 active site 1114958006581 prephenate dehydrogenase; Validated; Region: PRK06545 1114958006582 prephenate dehydrogenase; Validated; Region: PRK08507 1114958006583 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1114958006584 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1114958006585 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958006586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958006587 homodimer interface [polypeptide binding]; other site 1114958006588 catalytic residue [active] 1114958006589 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1114958006590 substrate binding site [chemical binding]; other site 1114958006591 active site 1114958006592 catalytic residues [active] 1114958006593 heterodimer interface [polypeptide binding]; other site 1114958006594 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1114958006595 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1114958006596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958006597 catalytic residue [active] 1114958006598 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1114958006599 active site 1114958006600 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1114958006601 active site 1114958006602 ribulose/triose binding site [chemical binding]; other site 1114958006603 phosphate binding site [ion binding]; other site 1114958006604 substrate (anthranilate) binding pocket [chemical binding]; other site 1114958006605 product (indole) binding pocket [chemical binding]; other site 1114958006606 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1114958006607 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1114958006608 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1114958006609 anthranilate synthase component I; Provisional; Region: PRK13569 1114958006610 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1114958006611 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1114958006612 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1114958006613 homotrimer interaction site [polypeptide binding]; other site 1114958006614 active site 1114958006615 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1114958006616 active site 1114958006617 dimer interface [polypeptide binding]; other site 1114958006618 metal binding site [ion binding]; metal-binding site 1114958006619 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1114958006620 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1114958006621 Tetramer interface [polypeptide binding]; other site 1114958006622 active site 1114958006623 FMN-binding site [chemical binding]; other site 1114958006624 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1114958006625 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1114958006626 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1114958006627 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1114958006628 active site 1114958006629 multimer interface [polypeptide binding]; other site 1114958006630 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1114958006631 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1114958006632 substrate binding pocket [chemical binding]; other site 1114958006633 chain length determination region; other site 1114958006634 substrate-Mg2+ binding site; other site 1114958006635 catalytic residues [active] 1114958006636 aspartate-rich region 1; other site 1114958006637 active site lid residues [active] 1114958006638 aspartate-rich region 2; other site 1114958006639 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1114958006640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958006641 S-adenosylmethionine binding site [chemical binding]; other site 1114958006642 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1114958006643 Tryptophan RNA-binding attenuator protein; Region: TrpBP; pfam02081 1114958006644 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1114958006645 homodecamer interface [polypeptide binding]; other site 1114958006646 GTP cyclohydrolase I; Provisional; Region: PLN03044 1114958006647 active site 1114958006648 putative catalytic site residues [active] 1114958006649 zinc binding site [ion binding]; other site 1114958006650 GTP-CH-I/GFRP interaction surface; other site 1114958006651 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1114958006652 IHF dimer interface [polypeptide binding]; other site 1114958006653 IHF - DNA interface [nucleotide binding]; other site 1114958006654 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 1114958006655 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1114958006656 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1114958006657 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1114958006658 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1114958006659 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1114958006660 GTP-binding protein Der; Reviewed; Region: PRK00093 1114958006661 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1114958006662 G1 box; other site 1114958006663 GTP/Mg2+ binding site [chemical binding]; other site 1114958006664 Switch I region; other site 1114958006665 G2 box; other site 1114958006666 Switch II region; other site 1114958006667 G3 box; other site 1114958006668 G4 box; other site 1114958006669 G5 box; other site 1114958006670 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1114958006671 G1 box; other site 1114958006672 GTP/Mg2+ binding site [chemical binding]; other site 1114958006673 Switch I region; other site 1114958006674 G2 box; other site 1114958006675 G3 box; other site 1114958006676 Switch II region; other site 1114958006677 G4 box; other site 1114958006678 G5 box; other site 1114958006679 YpzI-like protein; Region: YpzI; pfam14140 1114958006680 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1114958006681 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1114958006682 homotetramer interface [polypeptide binding]; other site 1114958006683 FMN binding site [chemical binding]; other site 1114958006684 homodimer contacts [polypeptide binding]; other site 1114958006685 putative active site [active] 1114958006686 putative substrate binding site [chemical binding]; other site 1114958006687 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1114958006688 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1114958006689 RNA binding site [nucleotide binding]; other site 1114958006690 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1114958006691 RNA binding site [nucleotide binding]; other site 1114958006692 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1114958006693 RNA binding site [nucleotide binding]; other site 1114958006694 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1114958006695 RNA binding site [nucleotide binding]; other site 1114958006696 cytidylate kinase; Provisional; Region: cmk; PRK00023 1114958006697 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1114958006698 CMP-binding site; other site 1114958006699 The sites determining sugar specificity; other site 1114958006700 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1114958006701 PilZ domain; Region: PilZ; pfam07238 1114958006702 germination protein YpeB; Region: spore_YpeB; TIGR02889 1114958006703 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1114958006704 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1114958006705 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1114958006706 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1114958006707 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1114958006708 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1114958006709 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1114958006710 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1114958006711 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1114958006712 NAD(P) binding site [chemical binding]; other site 1114958006713 adaptor protein; Provisional; Region: PRK02899 1114958006714 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1114958006715 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114958006716 putative active site [active] 1114958006717 putative metal binding site [ion binding]; other site 1114958006718 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1114958006719 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1114958006720 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958006721 CAAX protease self-immunity; Region: Abi; pfam02517 1114958006722 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1114958006723 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958006724 ATP binding site [chemical binding]; other site 1114958006725 putative Mg++ binding site [ion binding]; other site 1114958006726 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958006727 nucleotide binding region [chemical binding]; other site 1114958006728 ATP-binding site [chemical binding]; other site 1114958006729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1114958006730 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1114958006731 Predicted membrane protein [Function unknown]; Region: COG3601 1114958006732 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1114958006733 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1114958006734 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1114958006735 ligand binding site [chemical binding]; other site 1114958006736 NAD binding site [chemical binding]; other site 1114958006737 dimerization interface [polypeptide binding]; other site 1114958006738 catalytic site [active] 1114958006739 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1114958006740 putative L-serine binding site [chemical binding]; other site 1114958006741 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1114958006742 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958006743 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958006744 DNA binding residues [nucleotide binding] 1114958006745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1114958006746 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958006747 dimerization interface [polypeptide binding]; other site 1114958006748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958006749 putative active site [active] 1114958006750 heme pocket [chemical binding]; other site 1114958006751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958006752 dimer interface [polypeptide binding]; other site 1114958006753 phosphorylation site [posttranslational modification] 1114958006754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958006755 ATP binding site [chemical binding]; other site 1114958006756 Mg2+ binding site [ion binding]; other site 1114958006757 G-X-G motif; other site 1114958006758 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958006759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958006760 active site 1114958006761 phosphorylation site [posttranslational modification] 1114958006762 intermolecular recognition site; other site 1114958006763 dimerization interface [polypeptide binding]; other site 1114958006764 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958006765 DNA binding site [nucleotide binding] 1114958006766 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1114958006767 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1114958006768 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1114958006769 ResB-like family; Region: ResB; pfam05140 1114958006770 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1114958006771 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1114958006772 catalytic residues [active] 1114958006773 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1114958006774 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958006775 RNA binding surface [nucleotide binding]; other site 1114958006776 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1114958006777 active site 1114958006778 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1114958006779 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1114958006780 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1114958006781 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1114958006782 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1114958006783 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1114958006784 segregation and condensation protein B; Region: TIGR00281 1114958006785 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1114958006786 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1114958006787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958006788 Coenzyme A binding pocket [chemical binding]; other site 1114958006789 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1114958006790 homopentamer interface [polypeptide binding]; other site 1114958006791 active site 1114958006792 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1114958006793 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1114958006794 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1114958006795 dimerization interface [polypeptide binding]; other site 1114958006796 active site 1114958006797 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1114958006798 Lumazine binding domain; Region: Lum_binding; pfam00677 1114958006799 Lumazine binding domain; Region: Lum_binding; pfam00677 1114958006800 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1114958006801 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1114958006802 catalytic motif [active] 1114958006803 Zn binding site [ion binding]; other site 1114958006804 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1114958006805 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1114958006806 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1114958006807 Catalytic site [active] 1114958006808 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1114958006809 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1114958006810 active site 1114958006811 Predicted secreted protein [Function unknown]; Region: COG4086 1114958006812 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1114958006813 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1114958006814 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1114958006815 active site 1114958006816 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114958006817 substrate binding site [chemical binding]; other site 1114958006818 catalytic residues [active] 1114958006819 dimer interface [polypeptide binding]; other site 1114958006820 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1114958006821 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 1114958006822 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1114958006823 stage V sporulation protein AD; Validated; Region: PRK08304 1114958006824 stage V sporulation protein AD; Provisional; Region: PRK12404 1114958006825 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1114958006826 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1114958006827 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1114958006828 sporulation sigma factor SigF; Validated; Region: PRK05572 1114958006829 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958006830 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114958006831 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958006832 DNA binding residues [nucleotide binding] 1114958006833 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1114958006834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958006835 ATP binding site [chemical binding]; other site 1114958006836 Mg2+ binding site [ion binding]; other site 1114958006837 G-X-G motif; other site 1114958006838 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 1114958006839 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1114958006840 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1114958006841 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1114958006842 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1114958006843 phosphopentomutase; Provisional; Region: PRK05362 1114958006844 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1114958006845 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1114958006846 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1114958006847 active site 1114958006848 Int/Topo IB signature motif; other site 1114958006849 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1114958006850 ferric uptake regulator; Provisional; Region: fur; PRK09462 1114958006851 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1114958006852 metal binding site 2 [ion binding]; metal-binding site 1114958006853 putative DNA binding helix; other site 1114958006854 metal binding site 1 [ion binding]; metal-binding site 1114958006855 dimer interface [polypeptide binding]; other site 1114958006856 structural Zn2+ binding site [ion binding]; other site 1114958006857 stage II sporulation protein M; Region: spo_II_M; TIGR02831 1114958006858 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1114958006859 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1114958006860 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1114958006861 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 1114958006862 NAD(P) binding pocket [chemical binding]; other site 1114958006863 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1114958006864 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1114958006865 Aspartase; Region: Aspartase; cd01357 1114958006866 active sites [active] 1114958006867 tetramer interface [polypeptide binding]; other site 1114958006868 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1114958006869 active site 1114958006870 homodimer interface [polypeptide binding]; other site 1114958006871 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114958006872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958006873 non-specific DNA binding site [nucleotide binding]; other site 1114958006874 salt bridge; other site 1114958006875 sequence-specific DNA binding site [nucleotide binding]; other site 1114958006876 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 1114958006877 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1114958006878 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1114958006879 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1114958006880 dimer interface [polypeptide binding]; other site 1114958006881 ADP-ribose binding site [chemical binding]; other site 1114958006882 active site 1114958006883 nudix motif; other site 1114958006884 metal binding site [ion binding]; metal-binding site 1114958006885 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1114958006886 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958006887 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114958006888 active site 1114958006889 catalytic tetrad [active] 1114958006890 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114958006891 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114958006892 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1114958006893 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1114958006894 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1114958006895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1114958006896 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114958006897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958006898 Coenzyme A binding pocket [chemical binding]; other site 1114958006899 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1114958006900 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1114958006901 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114958006902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958006903 Coenzyme A binding pocket [chemical binding]; other site 1114958006904 DNA polymerase IV; Reviewed; Region: PRK03103 1114958006905 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1114958006906 active site 1114958006907 DNA binding site [nucleotide binding] 1114958006908 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1114958006909 YolD-like protein; Region: YolD; pfam08863 1114958006910 YqzH-like protein; Region: YqzH; pfam14164 1114958006911 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114958006912 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114958006913 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958006914 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1114958006915 putative dimer interface [polypeptide binding]; other site 1114958006916 ligand binding site [chemical binding]; other site 1114958006917 Zn binding site [ion binding]; other site 1114958006918 pantothenate kinase; Provisional; Region: PRK05439 1114958006919 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1114958006920 ATP-binding site [chemical binding]; other site 1114958006921 CoA-binding site [chemical binding]; other site 1114958006922 Mg2+-binding site [ion binding]; other site 1114958006923 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1114958006924 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1114958006925 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958006926 catalytic residue [active] 1114958006927 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1114958006928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958006929 NAD(P) binding site [chemical binding]; other site 1114958006930 active site 1114958006931 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114958006932 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1114958006933 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1114958006934 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1114958006935 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958006936 substrate binding site [chemical binding]; other site 1114958006937 oxyanion hole (OAH) forming residues; other site 1114958006938 trimer interface [polypeptide binding]; other site 1114958006939 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1114958006940 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1114958006941 dimer interface [polypeptide binding]; other site 1114958006942 active site 1114958006943 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1114958006944 Cytochrome P450; Region: p450; cl12078 1114958006945 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1114958006946 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1114958006947 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958006948 polyketide synthase; Region: polyketide_synthase; cd08251 1114958006949 Enoylreductase; Region: PKS_ER; smart00829 1114958006950 putative NAD(P) binding site [chemical binding]; other site 1114958006951 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006952 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958006953 active site 1114958006954 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958006955 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958006956 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1114958006957 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958006958 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006959 active site 1114958006960 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006961 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958006962 putative NADP binding site [chemical binding]; other site 1114958006963 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958006964 active site 1114958006965 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006966 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958006967 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006968 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958006969 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006970 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006971 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958006972 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958006973 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958006974 putative NADP binding site [chemical binding]; other site 1114958006975 active site 1114958006976 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006977 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958006978 active site 1114958006979 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958006980 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958006981 putative NADP binding site [chemical binding]; other site 1114958006982 active site 1114958006983 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958006984 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006985 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958006986 active site 1114958006987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958006988 S-adenosylmethionine binding site [chemical binding]; other site 1114958006989 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958006990 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958006991 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958006992 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958006993 active site 1114958006994 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958006995 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958006996 KR domain; Region: KR; pfam08659 1114958006997 putative NADP binding site [chemical binding]; other site 1114958006998 active site 1114958006999 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958007000 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958007001 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958007002 active site 1114958007003 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958007004 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958007005 putative NADP binding site [chemical binding]; other site 1114958007006 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958007007 active site 1114958007008 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958007009 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958007010 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958007011 active site 1114958007012 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958007013 putative NADP binding site [chemical binding]; other site 1114958007014 active site 1114958007015 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958007016 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958007017 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958007018 active site 1114958007019 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958007020 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958007021 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958007022 active site 1114958007023 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958007024 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1114958007025 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958007026 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958007027 putative NADP binding site [chemical binding]; other site 1114958007028 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958007029 active site 1114958007030 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958007031 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958007032 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958007033 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958007034 active site 1114958007035 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958007036 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958007037 putative NADP binding site [chemical binding]; other site 1114958007038 active site 1114958007039 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958007040 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958007041 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958007042 active site 1114958007043 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1114958007044 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1114958007045 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958007046 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958007047 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958007048 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958007049 active site 1114958007050 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958007051 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958007052 putative NADP binding site [chemical binding]; other site 1114958007053 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958007054 active site 1114958007055 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958007056 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958007057 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1114958007058 active site 1114958007059 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1114958007060 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1114958007061 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1114958007062 active site 1114958007063 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1114958007064 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1114958007065 putative NADP binding site [chemical binding]; other site 1114958007066 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1114958007067 active site 1114958007068 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1114958007069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958007070 NAD(P) binding site [chemical binding]; other site 1114958007071 active site 1114958007072 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1114958007073 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1114958007074 acyl-activating enzyme (AAE) consensus motif; other site 1114958007075 active site 1114958007076 AMP binding site [chemical binding]; other site 1114958007077 CoA binding site [chemical binding]; other site 1114958007078 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1114958007079 biosynthesis cluster domain; Region: biosyn_clust_1; TIGR04098 1114958007080 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1114958007081 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1114958007082 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1114958007083 FMN binding site [chemical binding]; other site 1114958007084 substrate binding site [chemical binding]; other site 1114958007085 putative catalytic residue [active] 1114958007086 Transcription antiterminator [Transcription]; Region: NusG; COG0250 1114958007087 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 1114958007088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958007089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958007090 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958007091 dimerization interface [polypeptide binding]; other site 1114958007092 GlpM protein; Region: GlpM; cl01212 1114958007093 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1114958007094 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1114958007095 active site 1114958007096 FMN binding site [chemical binding]; other site 1114958007097 substrate binding site [chemical binding]; other site 1114958007098 homotetramer interface [polypeptide binding]; other site 1114958007099 catalytic residue [active] 1114958007100 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114958007101 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1114958007102 ribonuclease Z; Region: RNase_Z; TIGR02651 1114958007103 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1114958007104 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1114958007105 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1114958007106 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1114958007107 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1114958007108 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1114958007109 DNA polymerase IV; Validated; Region: PRK01810 1114958007110 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1114958007111 active site 1114958007112 DNA binding site [nucleotide binding] 1114958007113 OxaA-like protein precursor; Validated; Region: PRK01622 1114958007114 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1114958007115 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1114958007116 peptidase T-like protein; Region: PepT-like; TIGR01883 1114958007117 metal binding site [ion binding]; metal-binding site 1114958007118 putative dimer interface [polypeptide binding]; other site 1114958007119 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1114958007120 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1114958007121 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1114958007122 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958007123 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1114958007124 dimer interface [polypeptide binding]; other site 1114958007125 substrate binding site [chemical binding]; other site 1114958007126 metal binding site [ion binding]; metal-binding site 1114958007127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1114958007128 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1114958007129 Predicted membrane protein [Function unknown]; Region: COG4129 1114958007130 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1114958007131 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1114958007132 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114958007133 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114958007134 Walker A/P-loop; other site 1114958007135 ATP binding site [chemical binding]; other site 1114958007136 Q-loop/lid; other site 1114958007137 ABC transporter signature motif; other site 1114958007138 Walker B; other site 1114958007139 D-loop; other site 1114958007140 H-loop/switch region; other site 1114958007141 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114958007142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958007143 dimer interface [polypeptide binding]; other site 1114958007144 conserved gate region; other site 1114958007145 putative PBP binding loops; other site 1114958007146 ABC-ATPase subunit interface; other site 1114958007147 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114958007148 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114958007149 substrate binding pocket [chemical binding]; other site 1114958007150 membrane-bound complex binding site; other site 1114958007151 hinge residues; other site 1114958007152 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1114958007153 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1114958007154 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1114958007155 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1114958007156 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1114958007157 E3 interaction surface; other site 1114958007158 lipoyl attachment site [posttranslational modification]; other site 1114958007159 e3 binding domain; Region: E3_binding; pfam02817 1114958007160 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1114958007161 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1114958007162 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1114958007163 alpha subunit interface [polypeptide binding]; other site 1114958007164 TPP binding site [chemical binding]; other site 1114958007165 heterodimer interface [polypeptide binding]; other site 1114958007166 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114958007167 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1114958007168 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1114958007169 tetramer interface [polypeptide binding]; other site 1114958007170 TPP-binding site [chemical binding]; other site 1114958007171 heterodimer interface [polypeptide binding]; other site 1114958007172 phosphorylation loop region [posttranslational modification] 1114958007173 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1114958007174 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1114958007175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958007176 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1114958007177 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1114958007178 nucleotide binding site [chemical binding]; other site 1114958007179 Acetokinase family; Region: Acetate_kinase; cl17229 1114958007180 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1114958007181 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1114958007182 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1114958007183 NAD binding site [chemical binding]; other site 1114958007184 Phe binding site; other site 1114958007185 phosphate butyryltransferase; Validated; Region: PRK07742 1114958007186 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114958007187 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1114958007188 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958007189 putative active site [active] 1114958007190 heme pocket [chemical binding]; other site 1114958007191 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958007192 putative active site [active] 1114958007193 heme pocket [chemical binding]; other site 1114958007194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958007195 Walker A motif; other site 1114958007196 ATP binding site [chemical binding]; other site 1114958007197 Walker B motif; other site 1114958007198 arginine finger; other site 1114958007199 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114958007200 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1114958007201 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1114958007202 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1114958007203 tetramer interface [polypeptide binding]; other site 1114958007204 active site 1114958007205 Mg2+/Mn2+ binding site [ion binding]; other site 1114958007206 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1114958007207 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1114958007208 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1114958007209 dimer interface [polypeptide binding]; other site 1114958007210 Citrate synthase; Region: Citrate_synt; pfam00285 1114958007211 active site 1114958007212 coenzyme A binding site [chemical binding]; other site 1114958007213 citrylCoA binding site [chemical binding]; other site 1114958007214 oxalacetate/citrate binding site [chemical binding]; other site 1114958007215 catalytic triad [active] 1114958007216 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114958007217 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1114958007218 FAD binding site [chemical binding]; other site 1114958007219 homotetramer interface [polypeptide binding]; other site 1114958007220 substrate binding pocket [chemical binding]; other site 1114958007221 catalytic base [active] 1114958007222 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1114958007223 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1114958007224 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114958007225 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1114958007226 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114958007227 dimer interface [polypeptide binding]; other site 1114958007228 active site 1114958007229 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1114958007230 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1114958007231 active site 1114958007232 catalytic site [active] 1114958007233 metal binding site [ion binding]; metal-binding site 1114958007234 dimer interface [polypeptide binding]; other site 1114958007235 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1114958007236 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1114958007237 active site 1114958007238 metal binding site [ion binding]; metal-binding site 1114958007239 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1114958007240 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958007241 sequence-specific DNA binding site [nucleotide binding]; other site 1114958007242 salt bridge; other site 1114958007243 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1114958007244 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1114958007245 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1114958007246 putative active site [active] 1114958007247 putative FMN binding site [chemical binding]; other site 1114958007248 putative substrate binding site [chemical binding]; other site 1114958007249 putative catalytic residue [active] 1114958007250 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1114958007251 alanine racemase; Region: alr; TIGR00492 1114958007252 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1114958007253 active site 1114958007254 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1114958007255 dimer interface [polypeptide binding]; other site 1114958007256 substrate binding site [chemical binding]; other site 1114958007257 catalytic residues [active] 1114958007258 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1114958007259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958007260 active site 1114958007261 phosphorylation site [posttranslational modification] 1114958007262 intermolecular recognition site; other site 1114958007263 dimerization interface [polypeptide binding]; other site 1114958007264 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1114958007265 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1114958007266 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1114958007267 protein binding site [polypeptide binding]; other site 1114958007268 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1114958007269 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1114958007270 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1114958007271 Walker A/P-loop; other site 1114958007272 ATP binding site [chemical binding]; other site 1114958007273 Q-loop/lid; other site 1114958007274 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1114958007275 ABC transporter signature motif; other site 1114958007276 Walker B; other site 1114958007277 D-loop; other site 1114958007278 H-loop/switch region; other site 1114958007279 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1114958007280 arginine repressor; Provisional; Region: PRK04280 1114958007281 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1114958007282 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1114958007283 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958007284 RNA binding surface [nucleotide binding]; other site 1114958007285 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1114958007286 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1114958007287 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1114958007288 TPP-binding site; other site 1114958007289 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1114958007290 PYR/PP interface [polypeptide binding]; other site 1114958007291 dimer interface [polypeptide binding]; other site 1114958007292 TPP binding site [chemical binding]; other site 1114958007293 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1114958007294 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1114958007295 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1114958007296 substrate binding pocket [chemical binding]; other site 1114958007297 chain length determination region; other site 1114958007298 substrate-Mg2+ binding site; other site 1114958007299 catalytic residues [active] 1114958007300 aspartate-rich region 1; other site 1114958007301 active site lid residues [active] 1114958007302 aspartate-rich region 2; other site 1114958007303 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 1114958007304 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1114958007305 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1114958007306 generic binding surface II; other site 1114958007307 generic binding surface I; other site 1114958007308 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 1114958007309 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1114958007310 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1114958007311 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1114958007312 homodimer interface [polypeptide binding]; other site 1114958007313 NADP binding site [chemical binding]; other site 1114958007314 substrate binding site [chemical binding]; other site 1114958007315 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1114958007316 putative RNA binding site [nucleotide binding]; other site 1114958007317 Asp23 family; Region: Asp23; pfam03780 1114958007318 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1114958007319 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1114958007320 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1114958007321 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1114958007322 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1114958007323 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1114958007324 carboxyltransferase (CT) interaction site; other site 1114958007325 biotinylation site [posttranslational modification]; other site 1114958007326 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1114958007327 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1114958007328 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1114958007329 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 1114958007330 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1114958007331 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 1114958007332 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1114958007333 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1114958007334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958007335 Walker A motif; other site 1114958007336 ATP binding site [chemical binding]; other site 1114958007337 Walker B motif; other site 1114958007338 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1114958007339 elongation factor P; Validated; Region: PRK00529 1114958007340 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1114958007341 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1114958007342 RNA binding site [nucleotide binding]; other site 1114958007343 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1114958007344 RNA binding site [nucleotide binding]; other site 1114958007345 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1114958007346 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1114958007347 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1114958007348 active site 1114958007349 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1114958007350 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1114958007351 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1114958007352 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1114958007353 active site 1114958007354 nucleophile elbow; other site 1114958007355 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1114958007356 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1114958007357 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1114958007358 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1114958007359 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1114958007360 active site residue [active] 1114958007361 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1114958007362 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1114958007363 tetramer interface [polypeptide binding]; other site 1114958007364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958007365 catalytic residue [active] 1114958007366 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1114958007367 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1114958007368 tetramer interface [polypeptide binding]; other site 1114958007369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958007370 catalytic residue [active] 1114958007371 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1114958007372 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1114958007373 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1114958007374 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1114958007375 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958007376 ATP binding site [chemical binding]; other site 1114958007377 putative Mg++ binding site [ion binding]; other site 1114958007378 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958007379 nucleotide binding region [chemical binding]; other site 1114958007380 ATP-binding site [chemical binding]; other site 1114958007381 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1114958007382 Anti-repressor SinI; Region: SinI; pfam08671 1114958007383 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114958007384 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958007385 non-specific DNA binding site [nucleotide binding]; other site 1114958007386 salt bridge; other site 1114958007387 sequence-specific DNA binding site [nucleotide binding]; other site 1114958007388 Anti-repressor SinI; Region: SinI; pfam08671 1114958007389 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1114958007390 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1114958007391 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1114958007392 Catalytic site [active] 1114958007393 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1114958007394 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1114958007395 YqzE-like protein; Region: YqzE; pfam14038 1114958007396 ComG operon protein 7; Region: ComGG; pfam14173 1114958007397 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1114958007398 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1114958007399 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1114958007400 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1114958007401 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1114958007402 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1114958007403 Type II/IV secretion system protein; Region: T2SE; pfam00437 1114958007404 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1114958007405 Walker A motif; other site 1114958007406 ATP binding site [chemical binding]; other site 1114958007407 Walker B motif; other site 1114958007408 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1114958007409 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1114958007410 Cl binding site [ion binding]; other site 1114958007411 oligomer interface [polypeptide binding]; other site 1114958007412 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1114958007413 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114958007414 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114958007415 Transporter associated domain; Region: CorC_HlyC; smart01091 1114958007416 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1114958007417 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1114958007418 ArsC family; Region: ArsC; pfam03960 1114958007419 putative catalytic residues [active] 1114958007420 thiol/disulfide switch; other site 1114958007421 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1114958007422 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114958007423 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1114958007424 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1114958007425 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1114958007426 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1114958007427 putative active site [active] 1114958007428 Zn binding site [ion binding]; other site 1114958007429 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1114958007430 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1114958007431 nucleotide binding site [chemical binding]; other site 1114958007432 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1114958007433 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1114958007434 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 1114958007435 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1114958007436 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1114958007437 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1114958007438 YceG-like family; Region: YceG; pfam02618 1114958007439 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1114958007440 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1114958007441 Walker A/P-loop; other site 1114958007442 ATP binding site [chemical binding]; other site 1114958007443 Q-loop/lid; other site 1114958007444 ABC transporter signature motif; other site 1114958007445 Walker B; other site 1114958007446 D-loop; other site 1114958007447 H-loop/switch region; other site 1114958007448 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1114958007449 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1114958007450 Walker A/P-loop; other site 1114958007451 ATP binding site [chemical binding]; other site 1114958007452 Q-loop/lid; other site 1114958007453 ABC transporter signature motif; other site 1114958007454 Walker B; other site 1114958007455 D-loop; other site 1114958007456 H-loop/switch region; other site 1114958007457 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1114958007458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958007459 dimer interface [polypeptide binding]; other site 1114958007460 conserved gate region; other site 1114958007461 ABC-ATPase subunit interface; other site 1114958007462 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1114958007463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958007464 dimer interface [polypeptide binding]; other site 1114958007465 conserved gate region; other site 1114958007466 putative PBP binding loops; other site 1114958007467 ABC-ATPase subunit interface; other site 1114958007468 PBP superfamily domain; Region: PBP_like_2; cl17296 1114958007469 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1114958007470 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1114958007471 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114958007472 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1114958007473 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958007474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958007475 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1114958007476 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1114958007477 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1114958007478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 1114958007479 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1114958007480 Lysin motif; Region: LysM; smart00257 1114958007481 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1114958007482 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1114958007483 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1114958007484 Uncharacterized conserved protein [Function unknown]; Region: COG5663 1114958007485 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1114958007486 metal binding site 2 [ion binding]; metal-binding site 1114958007487 putative DNA binding helix; other site 1114958007488 metal binding site 1 [ion binding]; metal-binding site 1114958007489 dimer interface [polypeptide binding]; other site 1114958007490 structural Zn2+ binding site [ion binding]; other site 1114958007491 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958007492 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958007493 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1114958007494 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1114958007495 endonuclease IV; Provisional; Region: PRK01060 1114958007496 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1114958007497 Metal-binding active site; metal-binding site 1114958007498 AP (apurinic/apyrimidinic) site pocket; other site 1114958007499 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114958007500 DNA interaction; other site 1114958007501 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114958007502 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1114958007503 ATP binding site [chemical binding]; other site 1114958007504 Mg++ binding site [ion binding]; other site 1114958007505 motif III; other site 1114958007506 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958007507 nucleotide binding region [chemical binding]; other site 1114958007508 ATP-binding site [chemical binding]; other site 1114958007509 YqfQ-like protein; Region: YqfQ; pfam14181 1114958007510 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1114958007511 LytB protein; Region: LYTB; pfam02401 1114958007512 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1114958007513 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1114958007514 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1114958007515 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1114958007516 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1114958007517 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1114958007518 Family of unknown function (DUF633); Region: DUF633; pfam04816 1114958007519 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1114958007520 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1114958007521 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1114958007522 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1114958007523 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1114958007524 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958007525 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1114958007526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958007527 DNA binding residues [nucleotide binding] 1114958007528 DNA primase; Validated; Region: dnaG; PRK05667 1114958007529 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1114958007530 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1114958007531 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1114958007532 active site 1114958007533 metal binding site [ion binding]; metal-binding site 1114958007534 interdomain interaction site; other site 1114958007535 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1114958007536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1114958007537 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1114958007538 HTH domain; Region: HTH_11; pfam08279 1114958007539 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1114958007540 FOG: CBS domain [General function prediction only]; Region: COG0517 1114958007541 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1114958007542 DALR anticodon binding domain; Region: DALR_1; pfam05746 1114958007543 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1114958007544 dimer interface [polypeptide binding]; other site 1114958007545 motif 1; other site 1114958007546 active site 1114958007547 motif 2; other site 1114958007548 motif 3; other site 1114958007549 Recombination protein O N terminal; Region: RecO_N; pfam11967 1114958007550 DNA repair protein RecO; Region: reco; TIGR00613 1114958007551 Recombination protein O C terminal; Region: RecO_C; pfam02565 1114958007552 GTPase Era; Reviewed; Region: era; PRK00089 1114958007553 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1114958007554 G1 box; other site 1114958007555 GTP/Mg2+ binding site [chemical binding]; other site 1114958007556 Switch I region; other site 1114958007557 G2 box; other site 1114958007558 Switch II region; other site 1114958007559 G3 box; other site 1114958007560 G4 box; other site 1114958007561 G5 box; other site 1114958007562 KH domain; Region: KH_2; pfam07650 1114958007563 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1114958007564 active site 1114958007565 catalytic motif [active] 1114958007566 Zn binding site [ion binding]; other site 1114958007567 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1114958007568 metal-binding heat shock protein; Provisional; Region: PRK00016 1114958007569 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1114958007570 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1114958007571 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114958007572 Zn2+ binding site [ion binding]; other site 1114958007573 Mg2+ binding site [ion binding]; other site 1114958007574 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1114958007575 PhoH-like protein; Region: PhoH; pfam02562 1114958007576 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1114958007577 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1114958007578 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 1114958007579 hypothetical protein; Provisional; Region: PRK13665 1114958007580 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1114958007581 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1114958007582 dimer interface [polypeptide binding]; other site 1114958007583 active site residues [active] 1114958007584 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1114958007585 Yqey-like protein; Region: YqeY; pfam09424 1114958007586 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1114958007587 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1114958007588 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1114958007589 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1114958007590 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1114958007591 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1114958007592 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958007593 FeS/SAM binding site; other site 1114958007594 TRAM domain; Region: TRAM; cl01282 1114958007595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1114958007596 RNA methyltransferase, RsmE family; Region: TIGR00046 1114958007597 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1114958007598 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958007599 S-adenosylmethionine binding site [chemical binding]; other site 1114958007600 chaperone protein DnaJ; Provisional; Region: PRK14280 1114958007601 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1114958007602 HSP70 interaction site [polypeptide binding]; other site 1114958007603 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1114958007604 substrate binding site [polypeptide binding]; other site 1114958007605 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1114958007606 Zn binding sites [ion binding]; other site 1114958007607 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1114958007608 dimer interface [polypeptide binding]; other site 1114958007609 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1114958007610 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1114958007611 nucleotide binding site [chemical binding]; other site 1114958007612 NEF interaction site [polypeptide binding]; other site 1114958007613 SBD interface [polypeptide binding]; other site 1114958007614 GrpE; Region: GrpE; pfam01025 1114958007615 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1114958007616 dimer interface [polypeptide binding]; other site 1114958007617 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1114958007618 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1114958007619 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1114958007620 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1114958007621 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958007622 FeS/SAM binding site; other site 1114958007623 HemN C-terminal domain; Region: HemN_C; pfam06969 1114958007624 GTP-binding protein LepA; Provisional; Region: PRK05433 1114958007625 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1114958007626 G1 box; other site 1114958007627 putative GEF interaction site [polypeptide binding]; other site 1114958007628 GTP/Mg2+ binding site [chemical binding]; other site 1114958007629 Switch I region; other site 1114958007630 G2 box; other site 1114958007631 G3 box; other site 1114958007632 Switch II region; other site 1114958007633 G4 box; other site 1114958007634 G5 box; other site 1114958007635 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1114958007636 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1114958007637 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1114958007638 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1114958007639 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1114958007640 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1114958007641 germination protease; Provisional; Region: PRK02858 1114958007642 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1114958007643 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1114958007644 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1114958007645 YqzM-like protein; Region: YqzM; pfam14141 1114958007646 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1114958007647 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1114958007648 Competence protein; Region: Competence; pfam03772 1114958007649 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1114958007650 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1114958007651 catalytic motif [active] 1114958007652 Zn binding site [ion binding]; other site 1114958007653 SLBB domain; Region: SLBB; pfam10531 1114958007654 comEA protein; Region: comE; TIGR01259 1114958007655 Helix-hairpin-helix motif; Region: HHH; pfam00633 1114958007656 late competence protein ComER; Validated; Region: PRK07680 1114958007657 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1114958007658 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114958007659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958007660 S-adenosylmethionine binding site [chemical binding]; other site 1114958007661 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1114958007662 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114958007663 Zn2+ binding site [ion binding]; other site 1114958007664 Mg2+ binding site [ion binding]; other site 1114958007665 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1114958007666 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1114958007667 active site 1114958007668 (T/H)XGH motif; other site 1114958007669 putative RNA-binding protein, YhbY family; Region: RNA_bind_YhbY; TIGR00253 1114958007670 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1114958007671 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1114958007672 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1114958007673 shikimate binding site; other site 1114958007674 NAD(P) binding site [chemical binding]; other site 1114958007675 GTPase YqeH; Provisional; Region: PRK13796 1114958007676 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1114958007677 GTP/Mg2+ binding site [chemical binding]; other site 1114958007678 G4 box; other site 1114958007679 G5 box; other site 1114958007680 G1 box; other site 1114958007681 Switch I region; other site 1114958007682 G2 box; other site 1114958007683 G3 box; other site 1114958007684 Switch II region; other site 1114958007685 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1114958007686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958007687 active site 1114958007688 motif I; other site 1114958007689 motif II; other site 1114958007690 Sporulation inhibitor A; Region: Sda; pfam08970 1114958007691 GDSL-like Lipase/Acylhydrolase; Region: Lipase_GDSL; pfam00657 1114958007692 active site 1114958007693 catalytic triad [active] 1114958007694 oxyanion hole [active] 1114958007695 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1114958007696 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1114958007697 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1114958007698 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1114958007699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958007700 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114958007701 putative substrate translocation pore; other site 1114958007702 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1114958007703 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1114958007704 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958007705 DNA binding residues [nucleotide binding] 1114958007706 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1114958007707 Predicted transcriptional regulators [Transcription]; Region: COG1695 1114958007708 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1114958007709 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1114958007710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1114958007711 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1114958007712 hypothetical protein; Validated; Region: PRK06217 1114958007713 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 1114958007714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958007715 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958007716 putative substrate translocation pore; other site 1114958007717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958007718 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1114958007719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958007720 Coenzyme A binding pocket [chemical binding]; other site 1114958007721 DinB family; Region: DinB; pfam05163 1114958007722 DinB superfamily; Region: DinB_2; pfam12867 1114958007723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1114958007724 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958007725 active site 1114958007726 motif I; other site 1114958007727 motif II; other site 1114958007728 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114958007729 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958007730 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958007731 active site 1114958007732 motif I; other site 1114958007733 motif II; other site 1114958007734 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114958007735 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114958007736 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114958007737 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114958007738 putative active site [active] 1114958007739 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1114958007740 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1114958007741 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1114958007742 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1114958007743 active site 1114958007744 P-loop; other site 1114958007745 phosphorylation site [posttranslational modification] 1114958007746 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1114958007747 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114958007748 active site 1114958007749 phosphorylation site [posttranslational modification] 1114958007750 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1114958007751 HTH domain; Region: HTH_11; cl17392 1114958007752 Mga helix-turn-helix domain; Region: Mga; pfam05043 1114958007753 PRD domain; Region: PRD; pfam00874 1114958007754 PRD domain; Region: PRD; pfam00874 1114958007755 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1114958007756 active site 1114958007757 P-loop; other site 1114958007758 phosphorylation site [posttranslational modification] 1114958007759 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114958007760 active site 1114958007761 phosphorylation site [posttranslational modification] 1114958007762 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1114958007763 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1114958007764 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1114958007765 putative deacylase active site [active] 1114958007766 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958007767 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958007768 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1114958007769 putative dimerization interface [polypeptide binding]; other site 1114958007770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958007771 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958007772 putative substrate translocation pore; other site 1114958007773 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1114958007774 Cytochrome P450; Region: p450; pfam00067 1114958007775 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1114958007776 Flavodoxin; Region: Flavodoxin_1; pfam00258 1114958007777 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1114958007778 FAD binding pocket [chemical binding]; other site 1114958007779 FAD binding motif [chemical binding]; other site 1114958007780 catalytic residues [active] 1114958007781 NAD binding pocket [chemical binding]; other site 1114958007782 phosphate binding motif [ion binding]; other site 1114958007783 beta-alpha-beta structure motif; other site 1114958007784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958007785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958007786 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1114958007787 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 1114958007788 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1114958007789 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1114958007790 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1114958007791 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1114958007792 catalytic loop [active] 1114958007793 iron binding site [ion binding]; other site 1114958007794 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1114958007795 4Fe-4S binding domain; Region: Fer4; pfam00037 1114958007796 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1114958007797 [4Fe-4S] binding site [ion binding]; other site 1114958007798 molybdopterin cofactor binding site; other site 1114958007799 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1114958007800 molybdopterin cofactor binding site; other site 1114958007801 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1114958007802 YrhC-like protein; Region: YrhC; pfam14143 1114958007803 cystathionine beta-lyase; Provisional; Region: PRK07671 1114958007804 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1114958007805 homodimer interface [polypeptide binding]; other site 1114958007806 substrate-cofactor binding pocket; other site 1114958007807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958007808 catalytic residue [active] 1114958007809 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1114958007810 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1114958007811 dimer interface [polypeptide binding]; other site 1114958007812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958007813 catalytic residue [active] 1114958007814 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1114958007815 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1114958007816 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1114958007817 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1114958007818 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1114958007819 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1114958007820 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1114958007821 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1114958007822 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1114958007823 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1114958007824 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1114958007825 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1114958007826 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1114958007827 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1114958007828 ATP-binding site [chemical binding]; other site 1114958007829 Sugar specificity; other site 1114958007830 Pyrimidine base specificity; other site 1114958007831 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1114958007832 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1114958007833 Peptidase family U32; Region: Peptidase_U32; pfam01136 1114958007834 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1114958007835 Peptidase family U32; Region: Peptidase_U32; pfam01136 1114958007836 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1114958007837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958007838 S-adenosylmethionine binding site [chemical binding]; other site 1114958007839 conserved hypothetical protein, YceG family; Region: TIGR00247 1114958007840 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1114958007841 dimerization interface [polypeptide binding]; other site 1114958007842 hypothetical protein; Provisional; Region: PRK13678 1114958007843 RNAse H-fold protein YqgF; Region: RNAse_H_YqgF; TIGR00250 1114958007844 hypothetical protein; Provisional; Region: PRK05473 1114958007845 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1114958007846 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1114958007847 motif 1; other site 1114958007848 active site 1114958007849 motif 2; other site 1114958007850 motif 3; other site 1114958007851 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1114958007852 DHHA1 domain; Region: DHHA1; pfam02272 1114958007853 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114958007854 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114958007855 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114958007856 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114958007857 Walker A/P-loop; other site 1114958007858 ATP binding site [chemical binding]; other site 1114958007859 Q-loop/lid; other site 1114958007860 ABC transporter signature motif; other site 1114958007861 Walker B; other site 1114958007862 D-loop; other site 1114958007863 H-loop/switch region; other site 1114958007864 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1114958007865 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114958007866 substrate binding pocket [chemical binding]; other site 1114958007867 membrane-bound complex binding site; other site 1114958007868 hinge residues; other site 1114958007869 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114958007870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958007871 dimer interface [polypeptide binding]; other site 1114958007872 conserved gate region; other site 1114958007873 putative PBP binding loops; other site 1114958007874 ABC-ATPase subunit interface; other site 1114958007875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958007876 dimer interface [polypeptide binding]; other site 1114958007877 conserved gate region; other site 1114958007878 putative PBP binding loops; other site 1114958007879 ABC-ATPase subunit interface; other site 1114958007880 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1114958007881 PRC-barrel domain; Region: PRC; pfam05239 1114958007882 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1114958007883 AAA domain; Region: AAA_30; pfam13604 1114958007884 Family description; Region: UvrD_C_2; pfam13538 1114958007885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958007886 binding surface 1114958007887 TPR repeat; Region: TPR_11; pfam13414 1114958007888 TPR motif; other site 1114958007889 TPR repeat; Region: TPR_11; pfam13414 1114958007890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958007891 binding surface 1114958007892 TPR motif; other site 1114958007893 TPR repeat; Region: TPR_11; pfam13414 1114958007894 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1114958007895 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1114958007896 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1114958007897 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1114958007898 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958007899 catalytic residue [active] 1114958007900 Predicted transcriptional regulator [Transcription]; Region: COG1959 1114958007901 Transcriptional regulator; Region: Rrf2; pfam02082 1114958007902 recombination factor protein RarA; Reviewed; Region: PRK13342 1114958007903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958007904 Walker A motif; other site 1114958007905 ATP binding site [chemical binding]; other site 1114958007906 Walker B motif; other site 1114958007907 arginine finger; other site 1114958007908 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1114958007909 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1114958007910 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1114958007911 putative ATP binding site [chemical binding]; other site 1114958007912 putative substrate interface [chemical binding]; other site 1114958007913 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1114958007914 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1114958007915 dimer interface [polypeptide binding]; other site 1114958007916 anticodon binding site; other site 1114958007917 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1114958007918 homodimer interface [polypeptide binding]; other site 1114958007919 motif 1; other site 1114958007920 active site 1114958007921 motif 2; other site 1114958007922 GAD domain; Region: GAD; pfam02938 1114958007923 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1114958007924 motif 3; other site 1114958007925 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1114958007926 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1114958007927 dimer interface [polypeptide binding]; other site 1114958007928 motif 1; other site 1114958007929 active site 1114958007930 motif 2; other site 1114958007931 motif 3; other site 1114958007932 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1114958007933 anticodon binding site; other site 1114958007934 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1114958007935 Bacterial SH3 domain; Region: SH3_3; pfam08239 1114958007936 Bacterial SH3 domain; Region: SH3_3; pfam08239 1114958007937 Bacterial SH3 domain; Region: SH3_3; pfam08239 1114958007938 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1114958007939 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1114958007940 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1114958007941 active site 1114958007942 metal binding site [ion binding]; metal-binding site 1114958007943 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1114958007944 putative active site [active] 1114958007945 dimerization interface [polypeptide binding]; other site 1114958007946 putative tRNAtyr binding site [nucleotide binding]; other site 1114958007947 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1114958007948 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114958007949 Zn2+ binding site [ion binding]; other site 1114958007950 Mg2+ binding site [ion binding]; other site 1114958007951 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1114958007952 synthetase active site [active] 1114958007953 NTP binding site [chemical binding]; other site 1114958007954 metal binding site [ion binding]; metal-binding site 1114958007955 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1114958007956 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1114958007957 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958007958 active site 1114958007959 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1114958007960 DHH family; Region: DHH; pfam01368 1114958007961 DHHA1 domain; Region: DHHA1; pfam02272 1114958007962 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 1114958007963 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1114958007964 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1114958007965 TrkA-C domain; Region: TrkA_C; pfam02080 1114958007966 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1114958007967 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1114958007968 RDD family; Region: RDD; pfam06271 1114958007969 Protein export membrane protein; Region: SecD_SecF; pfam02355 1114958007970 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1114958007971 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1114958007972 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1114958007973 Predicted membrane protein [Function unknown]; Region: COG2323 1114958007974 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 1114958007975 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1114958007976 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1114958007977 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1114958007978 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1114958007979 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1114958007980 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1114958007981 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1114958007982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958007983 Walker A motif; other site 1114958007984 ATP binding site [chemical binding]; other site 1114958007985 Walker B motif; other site 1114958007986 arginine finger; other site 1114958007987 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1114958007988 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1114958007989 RuvA N terminal domain; Region: RuvA_N; pfam01330 1114958007990 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1114958007991 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1114958007992 BofC C-terminal domain; Region: BofC_C; pfam08955 1114958007993 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1114958007994 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1114958007995 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958007996 quinolinate synthetase; Provisional; Region: PRK09375 1114958007997 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1114958007998 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1114958007999 dimerization interface [polypeptide binding]; other site 1114958008000 active site 1114958008001 L-aspartate oxidase; Provisional; Region: PRK08071 1114958008002 L-aspartate oxidase; Provisional; Region: PRK06175 1114958008003 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1114958008004 cysteine desulfurase; Provisional; Region: PRK02948 1114958008005 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1114958008006 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958008007 catalytic residue [active] 1114958008008 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1114958008009 HTH domain; Region: HTH_11; pfam08279 1114958008010 3H domain; Region: 3H; pfam02829 1114958008011 prephenate dehydratase; Provisional; Region: PRK11898 1114958008012 Prephenate dehydratase; Region: PDT; pfam00800 1114958008013 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1114958008014 putative L-Phe binding site [chemical binding]; other site 1114958008015 hypothetical protein; Provisional; Region: PRK04435 1114958008016 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1114958008017 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1114958008018 GTP1/OBG; Region: GTP1_OBG; pfam01018 1114958008019 Obg GTPase; Region: Obg; cd01898 1114958008020 G1 box; other site 1114958008021 GTP/Mg2+ binding site [chemical binding]; other site 1114958008022 Switch I region; other site 1114958008023 G2 box; other site 1114958008024 G3 box; other site 1114958008025 Switch II region; other site 1114958008026 G4 box; other site 1114958008027 G5 box; other site 1114958008028 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1114958008029 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1114958008030 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1114958008031 hypothetical protein; Provisional; Region: PRK14553 1114958008032 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1114958008033 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1114958008034 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1114958008035 Peptidase family M50; Region: Peptidase_M50; pfam02163 1114958008036 active site 1114958008037 putative substrate binding region [chemical binding]; other site 1114958008038 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1114958008039 Peptidase family M23; Region: Peptidase_M23; pfam01551 1114958008040 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1114958008041 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1114958008042 Switch I; other site 1114958008043 Switch II; other site 1114958008044 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1114958008045 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1114958008046 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1114958008047 rod shape-determining protein MreC; Region: mreC; TIGR00219 1114958008048 rod shape-determining protein MreC; Region: MreC; pfam04085 1114958008049 rod shape-determining protein MreB; Provisional; Region: PRK13927 1114958008050 MreB and similar proteins; Region: MreB_like; cd10225 1114958008051 nucleotide binding site [chemical binding]; other site 1114958008052 Mg binding site [ion binding]; other site 1114958008053 putative protofilament interaction site [polypeptide binding]; other site 1114958008054 RodZ interaction site [polypeptide binding]; other site 1114958008055 hypothetical protein; Reviewed; Region: PRK00024 1114958008056 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1114958008057 MPN+ (JAMM) motif; other site 1114958008058 Zinc-binding site [ion binding]; other site 1114958008059 Maf-like protein; Region: Maf; pfam02545 1114958008060 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1114958008061 active site 1114958008062 dimer interface [polypeptide binding]; other site 1114958008063 Sporulation related domain; Region: SPOR; pfam05036 1114958008064 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1114958008065 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1114958008066 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1114958008067 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1114958008068 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114958008069 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114958008070 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1114958008071 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114958008072 active site 1114958008073 HIGH motif; other site 1114958008074 nucleotide binding site [chemical binding]; other site 1114958008075 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1114958008076 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1114958008077 active site 1114958008078 KMSKS motif; other site 1114958008079 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1114958008080 tRNA binding surface [nucleotide binding]; other site 1114958008081 anticodon binding site; other site 1114958008082 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1114958008083 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1114958008084 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1114958008085 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1114958008086 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1114958008087 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1114958008088 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1114958008089 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958008090 inhibitor-cofactor binding pocket; inhibition site 1114958008091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958008092 catalytic residue [active] 1114958008093 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1114958008094 dimer interface [polypeptide binding]; other site 1114958008095 active site 1114958008096 Schiff base residues; other site 1114958008097 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1114958008098 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1114958008099 active site 1114958008100 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1114958008101 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1114958008102 domain interfaces; other site 1114958008103 active site 1114958008104 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 1114958008105 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1114958008106 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1114958008107 tRNA; other site 1114958008108 putative tRNA binding site [nucleotide binding]; other site 1114958008109 putative NADP binding site [chemical binding]; other site 1114958008110 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1114958008111 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1114958008112 G1 box; other site 1114958008113 GTP/Mg2+ binding site [chemical binding]; other site 1114958008114 Switch I region; other site 1114958008115 G2 box; other site 1114958008116 G3 box; other site 1114958008117 Switch II region; other site 1114958008118 G4 box; other site 1114958008119 G5 box; other site 1114958008120 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1114958008121 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1114958008122 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1114958008123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958008124 Walker A motif; other site 1114958008125 ATP binding site [chemical binding]; other site 1114958008126 Walker B motif; other site 1114958008127 arginine finger; other site 1114958008128 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1114958008129 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1114958008130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958008131 Walker A motif; other site 1114958008132 ATP binding site [chemical binding]; other site 1114958008133 Walker B motif; other site 1114958008134 arginine finger; other site 1114958008135 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1114958008136 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1114958008137 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1114958008138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958008139 Walker A motif; other site 1114958008140 ATP binding site [chemical binding]; other site 1114958008141 Walker B motif; other site 1114958008142 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1114958008143 trigger factor; Provisional; Region: tig; PRK01490 1114958008144 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1114958008145 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1114958008146 TPR repeat; Region: TPR_11; pfam13414 1114958008147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958008148 binding surface 1114958008149 TPR motif; other site 1114958008150 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1114958008151 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1114958008152 substrate binding site [chemical binding]; other site 1114958008153 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1114958008154 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1114958008155 substrate binding site [chemical binding]; other site 1114958008156 ligand binding site [chemical binding]; other site 1114958008157 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1114958008158 tartrate dehydrogenase; Region: TTC; TIGR02089 1114958008159 2-isopropylmalate synthase; Validated; Region: PRK00915 1114958008160 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1114958008161 active site 1114958008162 catalytic residues [active] 1114958008163 metal binding site [ion binding]; metal-binding site 1114958008164 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1114958008165 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1114958008166 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1114958008167 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1114958008168 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1114958008169 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1114958008170 putative valine binding site [chemical binding]; other site 1114958008171 dimer interface [polypeptide binding]; other site 1114958008172 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1114958008173 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1114958008174 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114958008175 PYR/PP interface [polypeptide binding]; other site 1114958008176 dimer interface [polypeptide binding]; other site 1114958008177 TPP binding site [chemical binding]; other site 1114958008178 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1114958008179 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1114958008180 TPP-binding site [chemical binding]; other site 1114958008181 dimer interface [polypeptide binding]; other site 1114958008182 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1114958008183 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114958008184 active site 1114958008185 metal binding site [ion binding]; metal-binding site 1114958008186 homotetramer interface [polypeptide binding]; other site 1114958008187 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1114958008188 active site 1114958008189 dimerization interface [polypeptide binding]; other site 1114958008190 ribonuclease PH; Reviewed; Region: rph; PRK00173 1114958008191 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1114958008192 hexamer interface [polypeptide binding]; other site 1114958008193 active site 1114958008194 Sporulation and spore germination; Region: Germane; pfam10646 1114958008195 Spore germination protein [General function prediction only]; Region: COG5401 1114958008196 Sporulation and spore germination; Region: Germane; pfam10646 1114958008197 glutamate racemase; Provisional; Region: PRK00865 1114958008198 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958008199 MarR family; Region: MarR; pfam01047 1114958008200 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114958008201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958008202 DNA binding residues [nucleotide binding] 1114958008203 dimerization interface [polypeptide binding]; other site 1114958008204 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1114958008205 active site 1114958008206 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1114958008207 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1114958008208 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1114958008209 L-aspartate oxidase; Provisional; Region: PRK06175 1114958008210 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1114958008211 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1114958008212 putative Iron-sulfur protein interface [polypeptide binding]; other site 1114958008213 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1114958008214 proximal heme binding site [chemical binding]; other site 1114958008215 distal heme binding site [chemical binding]; other site 1114958008216 putative dimer interface [polypeptide binding]; other site 1114958008217 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1114958008218 aspartate kinase; Reviewed; Region: PRK06635 1114958008219 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1114958008220 putative nucleotide binding site [chemical binding]; other site 1114958008221 putative catalytic residues [active] 1114958008222 putative Mg ion binding site [ion binding]; other site 1114958008223 putative aspartate binding site [chemical binding]; other site 1114958008224 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1114958008225 putative allosteric regulatory site; other site 1114958008226 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1114958008227 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1114958008228 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1114958008229 GIY-YIG motif/motif A; other site 1114958008230 active site 1114958008231 catalytic site [active] 1114958008232 putative DNA binding site [nucleotide binding]; other site 1114958008233 metal binding site [ion binding]; metal-binding site 1114958008234 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1114958008235 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114958008236 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1114958008237 catalytic residues [active] 1114958008238 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1114958008239 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1114958008240 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1114958008241 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1114958008242 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1114958008243 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1114958008244 Ligand binding site [chemical binding]; other site 1114958008245 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1114958008246 enoyl-CoA hydratase; Provisional; Region: PRK07658 1114958008247 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958008248 substrate binding site [chemical binding]; other site 1114958008249 oxyanion hole (OAH) forming residues; other site 1114958008250 trimer interface [polypeptide binding]; other site 1114958008251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958008252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958008253 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1114958008254 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1114958008255 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1114958008256 acyl-activating enzyme (AAE) consensus motif; other site 1114958008257 putative AMP binding site [chemical binding]; other site 1114958008258 putative active site [active] 1114958008259 putative CoA binding site [chemical binding]; other site 1114958008260 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1114958008261 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1114958008262 Predicted membrane protein [Function unknown]; Region: COG3766 1114958008263 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1114958008264 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1114958008265 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1114958008266 MutS domain III; Region: MutS_III; pfam05192 1114958008267 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1114958008268 Walker A/P-loop; other site 1114958008269 ATP binding site [chemical binding]; other site 1114958008270 Q-loop/lid; other site 1114958008271 ABC transporter signature motif; other site 1114958008272 Walker B; other site 1114958008273 D-loop; other site 1114958008274 H-loop/switch region; other site 1114958008275 Smr domain; Region: Smr; pfam01713 1114958008276 hypothetical protein; Provisional; Region: PRK08609 1114958008277 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1114958008278 active site 1114958008279 primer binding site [nucleotide binding]; other site 1114958008280 NTP binding site [chemical binding]; other site 1114958008281 metal binding triad [ion binding]; metal-binding site 1114958008282 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1114958008283 active site 1114958008284 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1114958008285 Colicin V production protein; Region: Colicin_V; pfam02674 1114958008286 cell division protein ZapA; Provisional; Region: PRK14126 1114958008287 ribonuclease HIII; Provisional; Region: PRK00996 1114958008288 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1114958008289 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1114958008290 RNA/DNA hybrid binding site [nucleotide binding]; other site 1114958008291 active site 1114958008292 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1114958008293 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1114958008294 putative tRNA-binding site [nucleotide binding]; other site 1114958008295 B3/4 domain; Region: B3_4; pfam03483 1114958008296 tRNA synthetase B5 domain; Region: B5; smart00874 1114958008297 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1114958008298 dimer interface [polypeptide binding]; other site 1114958008299 motif 1; other site 1114958008300 motif 3; other site 1114958008301 motif 2; other site 1114958008302 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1114958008303 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1114958008304 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1114958008305 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1114958008306 dimer interface [polypeptide binding]; other site 1114958008307 motif 1; other site 1114958008308 active site 1114958008309 motif 2; other site 1114958008310 motif 3; other site 1114958008311 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1114958008312 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1114958008313 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1114958008314 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 1114958008315 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1114958008316 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1114958008317 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1114958008318 FAD binding domain; Region: FAD_binding_4; pfam01565 1114958008319 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1114958008320 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1114958008321 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1114958008322 Cysteine-rich domain; Region: CCG; pfam02754 1114958008323 Cysteine-rich domain; Region: CCG; pfam02754 1114958008324 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1114958008325 Carbon starvation protein CstA; Region: CstA; pfam02554 1114958008326 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1114958008327 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1114958008328 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1114958008329 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114958008330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958008331 putative PBP binding loops; other site 1114958008332 dimer interface [polypeptide binding]; other site 1114958008333 ABC-ATPase subunit interface; other site 1114958008334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958008335 dimer interface [polypeptide binding]; other site 1114958008336 conserved gate region; other site 1114958008337 putative PBP binding loops; other site 1114958008338 ABC-ATPase subunit interface; other site 1114958008339 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114958008340 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114958008341 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1114958008342 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1114958008343 active site 1114958008344 metal binding site [ion binding]; metal-binding site 1114958008345 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1114958008346 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958008347 active site 1114958008348 motif I; other site 1114958008349 motif II; other site 1114958008350 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958008351 motif II; other site 1114958008352 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1114958008353 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1114958008354 intersubunit interface [polypeptide binding]; other site 1114958008355 active site 1114958008356 Zn2+ binding site [ion binding]; other site 1114958008357 ribulokinase; Provisional; Region: PRK04123 1114958008358 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1114958008359 N- and C-terminal domain interface [polypeptide binding]; other site 1114958008360 active site 1114958008361 MgATP binding site [chemical binding]; other site 1114958008362 catalytic site [active] 1114958008363 metal binding site [ion binding]; metal-binding site 1114958008364 carbohydrate binding site [chemical binding]; other site 1114958008365 homodimer interface [polypeptide binding]; other site 1114958008366 L-arabinose isomerase; Provisional; Region: PRK02929 1114958008367 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1114958008368 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1114958008369 trimer interface [polypeptide binding]; other site 1114958008370 putative substrate binding site [chemical binding]; other site 1114958008371 putative metal binding site [ion binding]; other site 1114958008372 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1114958008373 substrate binding site [chemical binding]; other site 1114958008374 active site 1114958008375 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1114958008376 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1114958008377 oligomer interface [polypeptide binding]; other site 1114958008378 active site 1114958008379 metal binding site [ion binding]; metal-binding site 1114958008380 Predicted integral membrane protein [Function unknown]; Region: COG5615 1114958008381 Predicted membrane protein [Function unknown]; Region: COG3326 1114958008382 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1114958008383 23S rRNA binding site [nucleotide binding]; other site 1114958008384 L21 binding site [polypeptide binding]; other site 1114958008385 L13 binding site [polypeptide binding]; other site 1114958008386 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1114958008387 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1114958008388 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1114958008389 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1114958008390 antiholin-like protein LrgB; Provisional; Region: PRK04288 1114958008391 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 1114958008392 two-component response regulator; Provisional; Region: PRK14084 1114958008393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958008394 active site 1114958008395 phosphorylation site [posttranslational modification] 1114958008396 intermolecular recognition site; other site 1114958008397 dimerization interface [polypeptide binding]; other site 1114958008398 LytTr DNA-binding domain; Region: LytTR; smart00850 1114958008399 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1114958008400 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1114958008401 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1114958008402 Histidine kinase; Region: His_kinase; pfam06580 1114958008403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958008404 ATP binding site [chemical binding]; other site 1114958008405 Mg2+ binding site [ion binding]; other site 1114958008406 G-X-G motif; other site 1114958008407 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1114958008408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958008409 motif II; other site 1114958008410 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1114958008411 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1114958008412 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1114958008413 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1114958008414 active site 1114958008415 dimer interface [polypeptide binding]; other site 1114958008416 motif 1; other site 1114958008417 motif 2; other site 1114958008418 motif 3; other site 1114958008419 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1114958008420 anticodon binding site; other site 1114958008421 YtxC-like family; Region: YtxC; pfam08812 1114958008422 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1114958008423 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1114958008424 primosomal protein DnaI; Reviewed; Region: PRK08939 1114958008425 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1114958008426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1114958008427 Walker A motif; other site 1114958008428 ATP binding site [chemical binding]; other site 1114958008429 Walker B motif; other site 1114958008430 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1114958008431 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1114958008432 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1114958008433 ATP cone domain; Region: ATP-cone; pfam03477 1114958008434 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 1114958008435 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1114958008436 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1114958008437 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1114958008438 Predicted transcriptional regulators [Transcription]; Region: COG1733 1114958008439 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1114958008440 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114958008441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958008442 putative substrate translocation pore; other site 1114958008443 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958008444 active site 1114958008445 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114958008446 catalytic tetrad [active] 1114958008447 dephospho-CoA kinase; Region: TIGR00152 1114958008448 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1114958008449 CoA-binding site [chemical binding]; other site 1114958008450 ATP-binding [chemical binding]; other site 1114958008451 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1114958008452 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1114958008453 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1114958008454 DNA binding site [nucleotide binding] 1114958008455 catalytic residue [active] 1114958008456 H2TH interface [polypeptide binding]; other site 1114958008457 putative catalytic residues [active] 1114958008458 turnover-facilitating residue; other site 1114958008459 intercalation triad [nucleotide binding]; other site 1114958008460 8OG recognition residue [nucleotide binding]; other site 1114958008461 putative reading head residues; other site 1114958008462 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1114958008463 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1114958008464 DNA polymerase I; Provisional; Region: PRK05755 1114958008465 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1114958008466 active site 1114958008467 metal binding site 1 [ion binding]; metal-binding site 1114958008468 putative 5' ssDNA interaction site; other site 1114958008469 metal binding site 3; metal-binding site 1114958008470 metal binding site 2 [ion binding]; metal-binding site 1114958008471 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1114958008472 putative DNA binding site [nucleotide binding]; other site 1114958008473 putative metal binding site [ion binding]; other site 1114958008474 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1114958008475 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1114958008476 active site 1114958008477 DNA binding site [nucleotide binding] 1114958008478 catalytic site [active] 1114958008479 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1114958008480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958008481 putative active site [active] 1114958008482 heme pocket [chemical binding]; other site 1114958008483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958008484 dimer interface [polypeptide binding]; other site 1114958008485 phosphorylation site [posttranslational modification] 1114958008486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958008487 ATP binding site [chemical binding]; other site 1114958008488 Mg2+ binding site [ion binding]; other site 1114958008489 G-X-G motif; other site 1114958008490 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958008491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958008492 active site 1114958008493 phosphorylation site [posttranslational modification] 1114958008494 intermolecular recognition site; other site 1114958008495 dimerization interface [polypeptide binding]; other site 1114958008496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958008497 DNA binding site [nucleotide binding] 1114958008498 malate dehydrogenase; Reviewed; Region: PRK06223 1114958008499 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1114958008500 NAD(P) binding site [chemical binding]; other site 1114958008501 dimer interface [polypeptide binding]; other site 1114958008502 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114958008503 substrate binding site [chemical binding]; other site 1114958008504 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1114958008505 isocitrate dehydrogenase; Validated; Region: PRK07362 1114958008506 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1114958008507 dimer interface [polypeptide binding]; other site 1114958008508 Citrate synthase; Region: Citrate_synt; pfam00285 1114958008509 active site 1114958008510 citrylCoA binding site [chemical binding]; other site 1114958008511 oxalacetate/citrate binding site [chemical binding]; other site 1114958008512 coenzyme A binding site [chemical binding]; other site 1114958008513 catalytic triad [active] 1114958008514 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1114958008515 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1114958008516 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 1114958008517 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114958008518 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1114958008519 pyruvate kinase; Provisional; Region: PRK06354 1114958008520 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1114958008521 domain interfaces; other site 1114958008522 active site 1114958008523 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1114958008524 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1114958008525 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1114958008526 active site 1114958008527 ADP/pyrophosphate binding site [chemical binding]; other site 1114958008528 dimerization interface [polypeptide binding]; other site 1114958008529 allosteric effector site; other site 1114958008530 fructose-1,6-bisphosphate binding site; other site 1114958008531 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1114958008532 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1114958008533 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1114958008534 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1114958008535 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1114958008536 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1114958008537 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1114958008538 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1114958008539 putative NAD(P) binding site [chemical binding]; other site 1114958008540 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1114958008541 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1114958008542 active site 1114958008543 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1114958008544 generic binding surface I; other site 1114958008545 generic binding surface II; other site 1114958008546 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1114958008547 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1114958008548 DHH family; Region: DHH; pfam01368 1114958008549 DHHA1 domain; Region: DHHA1; pfam02272 1114958008550 YtpI-like protein; Region: YtpI; pfam14007 1114958008551 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1114958008552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958008553 DNA-binding site [nucleotide binding]; DNA binding site 1114958008554 DRTGG domain; Region: DRTGG; pfam07085 1114958008555 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1114958008556 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1114958008557 active site 2 [active] 1114958008558 active site 1 [active] 1114958008559 metal-dependent hydrolase; Provisional; Region: PRK00685 1114958008560 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1114958008561 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1114958008562 classical (c) SDRs; Region: SDR_c; cd05233 1114958008563 NAD(P) binding site [chemical binding]; other site 1114958008564 active site 1114958008565 argininosuccinate lyase; Provisional; Region: PRK00855 1114958008566 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1114958008567 active sites [active] 1114958008568 tetramer interface [polypeptide binding]; other site 1114958008569 argininosuccinate synthase; Provisional; Region: PRK13820 1114958008570 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1114958008571 ANP binding site [chemical binding]; other site 1114958008572 Substrate Binding Site II [chemical binding]; other site 1114958008573 Substrate Binding Site I [chemical binding]; other site 1114958008574 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1114958008575 MPT binding site; other site 1114958008576 trimer interface [polypeptide binding]; other site 1114958008577 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1114958008578 propionate/acetate kinase; Provisional; Region: PRK12379 1114958008579 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1114958008580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958008581 S-adenosylmethionine binding site [chemical binding]; other site 1114958008582 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1114958008583 dimer interface [polypeptide binding]; other site 1114958008584 catalytic triad [active] 1114958008585 peroxidatic and resolving cysteines [active] 1114958008586 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 1114958008587 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1114958008588 RDD family; Region: RDD; pfam06271 1114958008589 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1114958008590 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1114958008591 tandem repeat interface [polypeptide binding]; other site 1114958008592 oligomer interface [polypeptide binding]; other site 1114958008593 active site residues [active] 1114958008594 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1114958008595 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1114958008596 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1114958008597 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1114958008598 active site 1114958008599 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958008600 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1114958008601 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1114958008602 active site 1114958008603 acyl-activating enzyme (AAE) consensus motif; other site 1114958008604 putative CoA binding site [chemical binding]; other site 1114958008605 AMP binding site [chemical binding]; other site 1114958008606 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1114958008607 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1114958008608 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1114958008609 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1114958008610 Ligand Binding Site [chemical binding]; other site 1114958008611 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1114958008612 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1114958008613 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958008614 catalytic residue [active] 1114958008615 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1114958008616 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 1114958008617 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1114958008618 histidinol-phosphatase; Reviewed; Region: PRK08123 1114958008619 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1114958008620 active site 1114958008621 dimer interface [polypeptide binding]; other site 1114958008622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958008623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958008624 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1114958008625 GAF domain; Region: GAF_2; pfam13185 1114958008626 GAF domain; Region: GAF_3; pfam13492 1114958008627 GAF domain; Region: GAF_2; pfam13185 1114958008628 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1114958008629 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1114958008630 metal binding site [ion binding]; metal-binding site 1114958008631 active site 1114958008632 I-site; other site 1114958008633 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1114958008634 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1114958008635 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958008636 RNA binding surface [nucleotide binding]; other site 1114958008637 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1114958008638 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1114958008639 NAD(P) binding site [chemical binding]; other site 1114958008640 catalytic residues [active] 1114958008641 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1114958008642 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1114958008643 heme-binding site [chemical binding]; other site 1114958008644 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1114958008645 FAD binding pocket [chemical binding]; other site 1114958008646 FAD binding motif [chemical binding]; other site 1114958008647 phosphate binding motif [ion binding]; other site 1114958008648 beta-alpha-beta structure motif; other site 1114958008649 NAD binding pocket [chemical binding]; other site 1114958008650 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1114958008651 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1114958008652 proposed catalytic triad [active] 1114958008653 conserved cys residue [active] 1114958008654 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1114958008655 active site 1114958008656 catalytic triad [active] 1114958008657 oxyanion hole [active] 1114958008658 Cytochrome c/c1 heme lyase; Region: Cyto_heme_lyase; pfam01265 1114958008659 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1114958008660 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1114958008661 Predicted transcriptional regulators [Transcription]; Region: COG1378 1114958008662 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1114958008663 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1114958008664 C-terminal domain interface [polypeptide binding]; other site 1114958008665 sugar binding site [chemical binding]; other site 1114958008666 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1114958008667 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1114958008668 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1114958008669 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1114958008670 active site 1114958008671 HIGH motif; other site 1114958008672 dimer interface [polypeptide binding]; other site 1114958008673 KMSKS motif; other site 1114958008674 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958008675 RNA binding surface [nucleotide binding]; other site 1114958008676 acetyl-CoA synthetase; Provisional; Region: PRK04319 1114958008677 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1114958008678 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1114958008679 active site 1114958008680 acyl-activating enzyme (AAE) consensus motif; other site 1114958008681 putative CoA binding site [chemical binding]; other site 1114958008682 AMP binding site [chemical binding]; other site 1114958008683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958008684 Coenzyme A binding pocket [chemical binding]; other site 1114958008685 FOG: CBS domain [General function prediction only]; Region: COG0517 1114958008686 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1114958008687 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1114958008688 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1114958008689 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1114958008690 active site 1114958008691 Zn binding site [ion binding]; other site 1114958008692 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1114958008693 flagellar motor protein MotS; Reviewed; Region: PRK06925 1114958008694 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1114958008695 ligand binding site [chemical binding]; other site 1114958008696 flagellar motor protein MotP; Reviewed; Region: PRK06926 1114958008697 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1114958008698 catabolite control protein A; Region: ccpA; TIGR01481 1114958008699 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958008700 DNA binding site [nucleotide binding] 1114958008701 domain linker motif; other site 1114958008702 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1114958008703 dimerization interface [polypeptide binding]; other site 1114958008704 effector binding site; other site 1114958008705 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1114958008706 Chorismate mutase type II; Region: CM_2; cl00693 1114958008707 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1114958008708 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 1114958008709 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1114958008710 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1114958008711 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1114958008712 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1114958008713 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114958008714 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1114958008715 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1114958008716 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1114958008717 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1114958008718 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1114958008719 putative tRNA-binding site [nucleotide binding]; other site 1114958008720 hypothetical protein; Provisional; Region: PRK13668 1114958008721 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114958008722 catalytic residues [active] 1114958008723 YtoQ family protein; Region: YtoQ_fam; TIGR03646 1114958008724 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1114958008725 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1114958008726 oligomer interface [polypeptide binding]; other site 1114958008727 active site 1114958008728 metal binding site [ion binding]; metal-binding site 1114958008729 Predicted small secreted protein [Function unknown]; Region: COG5584 1114958008730 malate dehydrogenase; Provisional; Region: PRK13529 1114958008731 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1114958008732 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1114958008733 NAD(P) binding site [chemical binding]; other site 1114958008734 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1114958008735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958008736 S-adenosylmethionine binding site [chemical binding]; other site 1114958008737 YtzH-like protein; Region: YtzH; pfam14165 1114958008738 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1114958008739 active site 1114958008740 ATP binding site [chemical binding]; other site 1114958008741 Phosphotransferase enzyme family; Region: APH; pfam01636 1114958008742 substrate binding site [chemical binding]; other site 1114958008743 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1114958008744 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1114958008745 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1114958008746 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1114958008747 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1114958008748 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1114958008749 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1114958008750 dimer interface [polypeptide binding]; other site 1114958008751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958008752 catalytic residue [active] 1114958008753 dipeptidase PepV; Reviewed; Region: PRK07318 1114958008754 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1114958008755 active site 1114958008756 metal binding site [ion binding]; metal-binding site 1114958008757 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1114958008758 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1114958008759 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1114958008760 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114958008761 Walker A/P-loop; other site 1114958008762 ATP binding site [chemical binding]; other site 1114958008763 Q-loop/lid; other site 1114958008764 ABC transporter signature motif; other site 1114958008765 Walker B; other site 1114958008766 D-loop; other site 1114958008767 H-loop/switch region; other site 1114958008768 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114958008769 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1114958008770 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1114958008771 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1114958008772 RNA binding surface [nucleotide binding]; other site 1114958008773 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1114958008774 active site 1114958008775 uracil binding [chemical binding]; other site 1114958008776 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1114958008777 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1114958008778 HI0933-like protein; Region: HI0933_like; pfam03486 1114958008779 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114958008780 BCCT family transporter; Region: BCCT; pfam02028 1114958008781 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1114958008782 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958008783 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958008784 DNA binding site [nucleotide binding] 1114958008785 domain linker motif; other site 1114958008786 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1114958008787 putative ligand binding site [chemical binding]; other site 1114958008788 putative dimerization interface [polypeptide binding]; other site 1114958008789 PBP superfamily domain; Region: PBP_like_2; cl17296 1114958008790 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114958008791 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1114958008792 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1114958008793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958008794 dimer interface [polypeptide binding]; other site 1114958008795 conserved gate region; other site 1114958008796 putative PBP binding loops; other site 1114958008797 ABC-ATPase subunit interface; other site 1114958008798 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114958008799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958008800 dimer interface [polypeptide binding]; other site 1114958008801 conserved gate region; other site 1114958008802 putative PBP binding loops; other site 1114958008803 ABC-ATPase subunit interface; other site 1114958008804 alpha-galactosidase; Provisional; Region: PRK15076 1114958008805 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1114958008806 NAD binding site [chemical binding]; other site 1114958008807 sugar binding site [chemical binding]; other site 1114958008808 divalent metal binding site [ion binding]; other site 1114958008809 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114958008810 dimer interface [polypeptide binding]; other site 1114958008811 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1114958008812 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958008813 Coenzyme A binding pocket [chemical binding]; other site 1114958008814 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1114958008815 active site residue [active] 1114958008816 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1114958008817 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1114958008818 HIGH motif; other site 1114958008819 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1114958008820 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1114958008821 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1114958008822 active site 1114958008823 KMSKS motif; other site 1114958008824 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1114958008825 tRNA binding surface [nucleotide binding]; other site 1114958008826 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1114958008827 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958008828 PAS domain; Region: PAS_9; pfam13426 1114958008829 putative active site [active] 1114958008830 heme pocket [chemical binding]; other site 1114958008831 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1114958008832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958008833 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958008834 putative substrate translocation pore; other site 1114958008835 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 1114958008836 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1114958008837 FtsX-like permease family; Region: FtsX; pfam02687 1114958008838 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114958008839 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114958008840 Walker A/P-loop; other site 1114958008841 ATP binding site [chemical binding]; other site 1114958008842 Q-loop/lid; other site 1114958008843 ABC transporter signature motif; other site 1114958008844 Walker B; other site 1114958008845 D-loop; other site 1114958008846 H-loop/switch region; other site 1114958008847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958008848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1114958008849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958008850 ATP binding site [chemical binding]; other site 1114958008851 Mg2+ binding site [ion binding]; other site 1114958008852 G-X-G motif; other site 1114958008853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958008854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958008855 active site 1114958008856 phosphorylation site [posttranslational modification] 1114958008857 intermolecular recognition site; other site 1114958008858 dimerization interface [polypeptide binding]; other site 1114958008859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958008860 DNA binding site [nucleotide binding] 1114958008861 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1114958008862 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1114958008863 FtsX-like permease family; Region: FtsX; pfam02687 1114958008864 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114958008865 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114958008866 Walker A/P-loop; other site 1114958008867 ATP binding site [chemical binding]; other site 1114958008868 Q-loop/lid; other site 1114958008869 ABC transporter signature motif; other site 1114958008870 Walker B; other site 1114958008871 D-loop; other site 1114958008872 H-loop/switch region; other site 1114958008873 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1114958008874 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1114958008875 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958008876 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114958008877 Walker A/P-loop; other site 1114958008878 ATP binding site [chemical binding]; other site 1114958008879 Q-loop/lid; other site 1114958008880 ABC transporter signature motif; other site 1114958008881 Walker B; other site 1114958008882 D-loop; other site 1114958008883 H-loop/switch region; other site 1114958008884 Predicted transcriptional regulators [Transcription]; Region: COG1725 1114958008885 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958008886 DNA-binding site [nucleotide binding]; DNA binding site 1114958008887 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1114958008888 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958008889 putative DNA binding site [nucleotide binding]; other site 1114958008890 putative Zn2+ binding site [ion binding]; other site 1114958008891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958008892 putative substrate translocation pore; other site 1114958008893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958008894 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1114958008895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958008896 S-adenosylmethionine binding site [chemical binding]; other site 1114958008897 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1114958008898 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1114958008899 active site 1114958008900 catalytic site [active] 1114958008901 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1114958008902 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1114958008903 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114958008904 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1114958008905 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1114958008906 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1114958008907 trimer interface [polypeptide binding]; other site 1114958008908 putative metal binding site [ion binding]; other site 1114958008909 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114958008910 Spore germination protein; Region: Spore_permease; cl17796 1114958008911 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1114958008912 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1114958008913 active site 1114958008914 dimer interface [polypeptide binding]; other site 1114958008915 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1114958008916 Ligand Binding Site [chemical binding]; other site 1114958008917 Molecular Tunnel; other site 1114958008918 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1114958008919 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1114958008920 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1114958008921 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1114958008922 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1114958008923 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1114958008924 active site 1114958008925 substrate-binding site [chemical binding]; other site 1114958008926 metal-binding site [ion binding] 1114958008927 ATP binding site [chemical binding]; other site 1114958008928 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1114958008929 Dienelactone hydrolase family; Region: DLH; pfam01738 1114958008930 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114958008931 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1114958008932 NMT1-like family; Region: NMT1_2; pfam13379 1114958008933 substrate binding pocket [chemical binding]; other site 1114958008934 membrane-bound complex binding site; other site 1114958008935 hinge residues; other site 1114958008936 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1114958008937 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1114958008938 Walker A/P-loop; other site 1114958008939 ATP binding site [chemical binding]; other site 1114958008940 Q-loop/lid; other site 1114958008941 ABC transporter signature motif; other site 1114958008942 Walker B; other site 1114958008943 D-loop; other site 1114958008944 H-loop/switch region; other site 1114958008945 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1114958008946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958008947 dimer interface [polypeptide binding]; other site 1114958008948 conserved gate region; other site 1114958008949 putative PBP binding loops; other site 1114958008950 ABC-ATPase subunit interface; other site 1114958008951 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1114958008952 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1114958008953 nudix motif; other site 1114958008954 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 1114958008955 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1114958008956 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1114958008957 dimerization interface [polypeptide binding]; other site 1114958008958 DPS ferroxidase diiron center [ion binding]; other site 1114958008959 ion pore; other site 1114958008960 YtkA-like; Region: YtkA; pfam13115 1114958008961 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1114958008962 Haemolytic domain; Region: Haemolytic; pfam01809 1114958008963 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1114958008964 active site clefts [active] 1114958008965 zinc binding site [ion binding]; other site 1114958008966 dimer interface [polypeptide binding]; other site 1114958008967 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1114958008968 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1114958008969 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1114958008970 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1114958008971 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1114958008972 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1114958008973 active site 1114958008974 octamer interface [polypeptide binding]; other site 1114958008975 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1114958008976 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1114958008977 acyl-activating enzyme (AAE) consensus motif; other site 1114958008978 putative AMP binding site [chemical binding]; other site 1114958008979 putative active site [active] 1114958008980 putative CoA binding site [chemical binding]; other site 1114958008981 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958008982 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1114958008983 substrate binding site [chemical binding]; other site 1114958008984 oxyanion hole (OAH) forming residues; other site 1114958008985 trimer interface [polypeptide binding]; other site 1114958008986 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1114958008987 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1114958008988 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1114958008989 dimer interface [polypeptide binding]; other site 1114958008990 tetramer interface [polypeptide binding]; other site 1114958008991 PYR/PP interface [polypeptide binding]; other site 1114958008992 TPP binding site [chemical binding]; other site 1114958008993 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1114958008994 TPP-binding site; other site 1114958008995 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1114958008996 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1114958008997 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1114958008998 TspO/MBR family; Region: TspO_MBR; cl01379 1114958008999 Predicted membrane protein [Function unknown]; Region: COG3859 1114958009000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1114958009001 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1114958009002 DinB superfamily; Region: DinB_2; pfam12867 1114958009003 DinB family; Region: DinB; cl17821 1114958009004 MOSC domain; Region: MOSC; pfam03473 1114958009005 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1114958009006 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1114958009007 active site 1114958009008 NAD binding site [chemical binding]; other site 1114958009009 metal binding site [ion binding]; metal-binding site 1114958009010 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1114958009011 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1114958009012 tetramerization interface [polypeptide binding]; other site 1114958009013 NAD(P) binding site [chemical binding]; other site 1114958009014 catalytic residues [active] 1114958009015 Predicted transcriptional regulators [Transcription]; Region: COG1510 1114958009016 MarR family; Region: MarR_2; pfam12802 1114958009017 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1114958009018 TrkA-N domain; Region: TrkA_N; pfam02254 1114958009019 TrkA-C domain; Region: TrkA_C; pfam02080 1114958009020 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1114958009021 SH3-like domain; Region: SH3_8; pfam13457 1114958009022 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1114958009023 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1114958009024 heme-binding site [chemical binding]; other site 1114958009025 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1114958009026 FAD binding pocket [chemical binding]; other site 1114958009027 FAD binding motif [chemical binding]; other site 1114958009028 phosphate binding motif [ion binding]; other site 1114958009029 beta-alpha-beta structure motif; other site 1114958009030 NAD binding pocket [chemical binding]; other site 1114958009031 Heme binding pocket [chemical binding]; other site 1114958009032 Cupin; Region: Cupin_1; smart00835 1114958009033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958009034 binding surface 1114958009035 TPR motif; other site 1114958009036 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958009037 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958009038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958009039 binding surface 1114958009040 TPR motif; other site 1114958009041 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1114958009042 amidase catalytic site [active] 1114958009043 Zn binding residues [ion binding]; other site 1114958009044 substrate binding site [chemical binding]; other site 1114958009045 Bacterial SH3 domain; Region: SH3_3; pfam08239 1114958009046 Holin family; Region: Phage_holin_4; cl01989 1114958009047 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 1114958009048 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1114958009049 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1114958009050 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1114958009051 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1114958009052 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1114958009053 Phage tail protein; Region: Sipho_tail; pfam05709 1114958009054 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1114958009055 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1114958009056 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1114958009057 catalytic residue [active] 1114958009058 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1114958009059 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1114958009060 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1114958009061 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1114958009062 oligomerization interface [polypeptide binding]; other site 1114958009063 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1114958009064 Phage capsid family; Region: Phage_capsid; pfam05065 1114958009065 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1114958009066 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1114958009067 oligomer interface [polypeptide binding]; other site 1114958009068 active site residues [active] 1114958009069 Phage-related protein [Function unknown]; Region: COG4695 1114958009070 Phage portal protein; Region: Phage_portal; pfam04860 1114958009071 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1114958009072 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1114958009073 HNH endonuclease; Region: HNH_3; pfam13392 1114958009074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958009075 non-specific DNA binding site [nucleotide binding]; other site 1114958009076 salt bridge; other site 1114958009077 sequence-specific DNA binding site [nucleotide binding]; other site 1114958009078 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1114958009079 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1114958009080 Int/Topo IB signature motif; other site 1114958009081 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1114958009082 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114958009083 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114958009084 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114958009085 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114958009086 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1114958009087 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1114958009088 proposed catalytic triad [active] 1114958009089 conserved cys residue [active] 1114958009090 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1114958009091 Cache domain; Region: Cache_1; pfam02743 1114958009092 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1114958009093 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958009094 dimerization interface [polypeptide binding]; other site 1114958009095 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958009096 dimer interface [polypeptide binding]; other site 1114958009097 putative CheW interface [polypeptide binding]; other site 1114958009098 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1114958009099 Cache domain; Region: Cache_1; pfam02743 1114958009100 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958009101 dimerization interface [polypeptide binding]; other site 1114958009102 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114958009103 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958009104 dimer interface [polypeptide binding]; other site 1114958009105 putative CheW interface [polypeptide binding]; other site 1114958009106 Tar ligand binding domain homologue; Region: TarH; pfam02203 1114958009107 Cache domain; Region: Cache_1; pfam02743 1114958009108 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958009109 dimerization interface [polypeptide binding]; other site 1114958009110 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114958009111 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958009112 dimer interface [polypeptide binding]; other site 1114958009113 putative CheW interface [polypeptide binding]; other site 1114958009114 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958009115 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1114958009116 Cache domain; Region: Cache_1; pfam02743 1114958009117 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958009118 dimerization interface [polypeptide binding]; other site 1114958009119 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1114958009120 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1114958009121 dimer interface [polypeptide binding]; other site 1114958009122 putative CheW interface [polypeptide binding]; other site 1114958009123 transglutaminase; Provisional; Region: tgl; PRK03187 1114958009124 Nitronate monooxygenase; Region: NMO; pfam03060 1114958009125 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1114958009126 FMN binding site [chemical binding]; other site 1114958009127 substrate binding site [chemical binding]; other site 1114958009128 putative catalytic residue [active] 1114958009129 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 1114958009130 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1114958009131 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1114958009132 Ca binding site [ion binding]; other site 1114958009133 active site 1114958009134 catalytic site [active] 1114958009135 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1114958009136 Domain of unknown function DUF21; Region: DUF21; pfam01595 1114958009137 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1114958009138 Transporter associated domain; Region: CorC_HlyC; smart01091 1114958009139 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1114958009140 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1114958009141 Ion channel; Region: Ion_trans_2; pfam07885 1114958009142 TrkA-N domain; Region: TrkA_N; pfam02254 1114958009143 YugN-like family; Region: YugN; pfam08868 1114958009144 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1114958009145 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1114958009146 active site 1114958009147 dimer interface [polypeptide binding]; other site 1114958009148 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1114958009149 dimer interface [polypeptide binding]; other site 1114958009150 active site 1114958009151 Predicted flavoprotein [General function prediction only]; Region: COG0431 1114958009152 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114958009153 Isochorismatase family; Region: Isochorismatase; pfam00857 1114958009154 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1114958009155 catalytic triad [active] 1114958009156 dimer interface [polypeptide binding]; other site 1114958009157 conserved cis-peptide bond; other site 1114958009158 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1114958009159 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1114958009160 dimer interface [polypeptide binding]; other site 1114958009161 active site 1114958009162 metal binding site [ion binding]; metal-binding site 1114958009163 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1114958009164 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1114958009165 dimer interface [polypeptide binding]; other site 1114958009166 active site 1114958009167 metal binding site [ion binding]; metal-binding site 1114958009168 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1114958009169 general stress protein 13; Validated; Region: PRK08059 1114958009170 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1114958009171 RNA binding site [nucleotide binding]; other site 1114958009172 hypothetical protein; Validated; Region: PRK07682 1114958009173 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958009174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958009175 homodimer interface [polypeptide binding]; other site 1114958009176 catalytic residue [active] 1114958009177 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114958009178 AsnC family; Region: AsnC_trans_reg; pfam01037 1114958009179 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1114958009180 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1114958009181 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1114958009182 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1114958009183 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958009184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958009185 homodimer interface [polypeptide binding]; other site 1114958009186 catalytic residue [active] 1114958009187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958009188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958009189 dimer interface [polypeptide binding]; other site 1114958009190 phosphorylation site [posttranslational modification] 1114958009191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958009192 ATP binding site [chemical binding]; other site 1114958009193 Mg2+ binding site [ion binding]; other site 1114958009194 G-X-G motif; other site 1114958009195 Kinase associated protein B; Region: KapB; pfam08810 1114958009196 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1114958009197 active site 1114958009198 catalytic site [active] 1114958009199 substrate binding site [chemical binding]; other site 1114958009200 drug efflux system protein MdtG; Provisional; Region: PRK09874 1114958009201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009202 putative substrate translocation pore; other site 1114958009203 Transglycosylase; Region: Transgly; pfam00912 1114958009204 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1114958009205 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1114958009206 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1114958009207 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1114958009208 PAS domain; Region: PAS; smart00091 1114958009209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958009210 ATP binding site [chemical binding]; other site 1114958009211 Mg2+ binding site [ion binding]; other site 1114958009212 G-X-G motif; other site 1114958009213 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1114958009214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958009215 active site 1114958009216 phosphorylation site [posttranslational modification] 1114958009217 intermolecular recognition site; other site 1114958009218 dimerization interface [polypeptide binding]; other site 1114958009219 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1114958009220 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1114958009221 ligand binding site [chemical binding]; other site 1114958009222 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1114958009223 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1114958009224 Walker A/P-loop; other site 1114958009225 ATP binding site [chemical binding]; other site 1114958009226 Q-loop/lid; other site 1114958009227 ABC transporter signature motif; other site 1114958009228 Walker B; other site 1114958009229 D-loop; other site 1114958009230 H-loop/switch region; other site 1114958009231 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1114958009232 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114958009233 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1114958009234 TM-ABC transporter signature motif; other site 1114958009235 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114958009236 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1114958009237 TM-ABC transporter signature motif; other site 1114958009238 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1114958009239 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1114958009240 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1114958009241 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1114958009242 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 1114958009243 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1114958009244 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1114958009245 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1114958009246 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1114958009247 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1114958009248 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1114958009249 CoenzymeA binding site [chemical binding]; other site 1114958009250 subunit interaction site [polypeptide binding]; other site 1114958009251 PHB binding site; other site 1114958009252 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958009253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958009254 active site 1114958009255 phosphorylation site [posttranslational modification] 1114958009256 intermolecular recognition site; other site 1114958009257 dimerization interface [polypeptide binding]; other site 1114958009258 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114958009259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114958009260 Histidine kinase; Region: HisKA_3; pfam07730 1114958009261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958009262 ATP binding site [chemical binding]; other site 1114958009263 Mg2+ binding site [ion binding]; other site 1114958009264 G-X-G motif; other site 1114958009265 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1114958009266 substrate binding pocket [chemical binding]; other site 1114958009267 substrate-Mg2+ binding site; other site 1114958009268 aspartate-rich region 1; other site 1114958009269 aspartate-rich region 2; other site 1114958009270 DegQ (SacQ) family; Region: DegQ; pfam08181 1114958009271 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1114958009272 EAL domain; Region: EAL; pfam00563 1114958009273 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1114958009274 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1114958009275 active site 1114958009276 Isochorismatase family; Region: Isochorismatase; pfam00857 1114958009277 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1114958009278 catalytic triad [active] 1114958009279 conserved cis-peptide bond; other site 1114958009280 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1114958009281 YueH-like protein; Region: YueH; pfam14166 1114958009282 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1114958009283 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1114958009284 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1114958009285 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1114958009286 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1114958009287 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114958009288 Zn2+ binding site [ion binding]; other site 1114958009289 Mg2+ binding site [ion binding]; other site 1114958009290 short chain dehydrogenase; Provisional; Region: PRK06924 1114958009291 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1114958009292 NADP binding site [chemical binding]; other site 1114958009293 homodimer interface [polypeptide binding]; other site 1114958009294 active site 1114958009295 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 1114958009296 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1114958009297 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1114958009298 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1114958009299 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1114958009300 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1114958009301 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1114958009302 Domain of unknown function DUF87; Region: DUF87; pfam01935 1114958009303 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1114958009304 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 1114958009305 Uncharacterized small protein [Function unknown]; Region: COG5417 1114958009306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1114958009307 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1114958009308 CodY GAF-like domain; Region: CodY; pfam06018 1114958009309 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1114958009310 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1114958009311 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1114958009312 hexamer interface [polypeptide binding]; other site 1114958009313 ligand binding site [chemical binding]; other site 1114958009314 putative active site [active] 1114958009315 NAD(P) binding site [chemical binding]; other site 1114958009316 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1114958009317 MbtH-like protein; Region: MbtH; cl01279 1114958009318 Condensation domain; Region: Condensation; pfam00668 1114958009319 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1114958009320 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1114958009321 acyl-activating enzyme (AAE) consensus motif; other site 1114958009322 AMP binding site [chemical binding]; other site 1114958009323 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958009324 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1114958009325 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1114958009326 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1114958009327 acyl-activating enzyme (AAE) consensus motif; other site 1114958009328 AMP binding site [chemical binding]; other site 1114958009329 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1114958009330 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1114958009331 hydrophobic substrate binding pocket; other site 1114958009332 Isochorismatase family; Region: Isochorismatase; pfam00857 1114958009333 active site 1114958009334 conserved cis-peptide bond; other site 1114958009335 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1114958009336 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1114958009337 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1114958009338 acyl-activating enzyme (AAE) consensus motif; other site 1114958009339 active site 1114958009340 AMP binding site [chemical binding]; other site 1114958009341 substrate binding site [chemical binding]; other site 1114958009342 isochorismate synthase DhbC; Validated; Region: PRK06923 1114958009343 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1114958009344 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1114958009345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958009346 NAD(P) binding site [chemical binding]; other site 1114958009347 active site 1114958009348 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1114958009349 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1114958009350 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1114958009351 Moco binding site; other site 1114958009352 metal coordination site [ion binding]; other site 1114958009353 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 1114958009354 Predicted permease [General function prediction only]; Region: COG2056 1114958009355 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 1114958009356 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1114958009357 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1114958009358 interface (dimer of trimers) [polypeptide binding]; other site 1114958009359 Substrate-binding/catalytic site; other site 1114958009360 Zn-binding sites [ion binding]; other site 1114958009361 Divergent PAP2 family; Region: DUF212; pfam02681 1114958009362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1114958009363 Putative membrane protein; Region: YuiB; pfam14068 1114958009364 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 1114958009365 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1114958009366 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958009367 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1114958009368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114958009369 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958009370 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1114958009371 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1114958009372 active site 1114958009373 Integral membrane protein DUF95; Region: DUF95; pfam01944 1114958009374 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1114958009375 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1114958009376 Walker A/P-loop; other site 1114958009377 ATP binding site [chemical binding]; other site 1114958009378 Q-loop/lid; other site 1114958009379 ABC transporter signature motif; other site 1114958009380 Walker B; other site 1114958009381 D-loop; other site 1114958009382 H-loop/switch region; other site 1114958009383 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1114958009384 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1114958009385 DNA binding residues [nucleotide binding] 1114958009386 putative dimer interface [polypeptide binding]; other site 1114958009387 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1114958009388 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1114958009389 putative NAD(P) binding site [chemical binding]; other site 1114958009390 active site 1114958009391 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1114958009392 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1114958009393 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114958009394 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1114958009395 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1114958009396 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1114958009397 Nucleoside recognition; Region: Gate; pfam07670 1114958009398 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1114958009399 hypothetical protein; Provisional; Region: PRK13669 1114958009400 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1114958009401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958009402 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 1114958009403 NifU-like domain; Region: NifU; pfam01106 1114958009404 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1114958009405 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1114958009406 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1114958009407 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1114958009408 homoserine kinase; Provisional; Region: PRK01212 1114958009409 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1114958009410 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1114958009411 threonine synthase; Reviewed; Region: PRK06721 1114958009412 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1114958009413 homodimer interface [polypeptide binding]; other site 1114958009414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958009415 catalytic residue [active] 1114958009416 homoserine dehydrogenase; Provisional; Region: PRK06349 1114958009417 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1114958009418 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1114958009419 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1114958009420 spore coat protein YutH; Region: spore_yutH; TIGR02905 1114958009421 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1114958009422 tetramer interfaces [polypeptide binding]; other site 1114958009423 binuclear metal-binding site [ion binding]; other site 1114958009424 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1114958009425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958009426 active site 1114958009427 motif I; other site 1114958009428 motif II; other site 1114958009429 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958009430 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1114958009431 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1114958009432 lipoyl synthase; Provisional; Region: PRK05481 1114958009433 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958009434 FeS/SAM binding site; other site 1114958009435 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1114958009436 Peptidase family M23; Region: Peptidase_M23; pfam01551 1114958009437 sporulation protein YunB; Region: spo_yunB; TIGR02832 1114958009438 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1114958009439 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1114958009440 active site 1114958009441 metal binding site [ion binding]; metal-binding site 1114958009442 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1114958009443 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1114958009444 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1114958009445 allantoinase; Provisional; Region: PRK06189 1114958009446 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1114958009447 active site 1114958009448 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1114958009449 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1114958009450 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1114958009451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009452 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958009453 putative substrate translocation pore; other site 1114958009454 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1114958009455 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958009456 catalytic residue [active] 1114958009457 allantoate amidohydrolase; Reviewed; Region: PRK09290 1114958009458 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1114958009459 active site 1114958009460 metal binding site [ion binding]; metal-binding site 1114958009461 dimer interface [polypeptide binding]; other site 1114958009462 Endonuclease I; Region: Endonuclease_1; cl01003 1114958009463 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1114958009464 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1114958009465 Walker A/P-loop; other site 1114958009466 ATP binding site [chemical binding]; other site 1114958009467 Q-loop/lid; other site 1114958009468 ABC transporter signature motif; other site 1114958009469 Walker B; other site 1114958009470 D-loop; other site 1114958009471 H-loop/switch region; other site 1114958009472 TOBE domain; Region: TOBE_2; pfam08402 1114958009473 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1114958009474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958009475 DNA-binding site [nucleotide binding]; DNA binding site 1114958009476 UTRA domain; Region: UTRA; pfam07702 1114958009477 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114958009478 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1114958009479 substrate binding site [chemical binding]; other site 1114958009480 ATP binding site [chemical binding]; other site 1114958009481 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1114958009482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009483 dimer interface [polypeptide binding]; other site 1114958009484 conserved gate region; other site 1114958009485 putative PBP binding loops; other site 1114958009486 ABC-ATPase subunit interface; other site 1114958009487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009488 dimer interface [polypeptide binding]; other site 1114958009489 conserved gate region; other site 1114958009490 putative PBP binding loops; other site 1114958009491 ABC-ATPase subunit interface; other site 1114958009492 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1114958009493 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1114958009494 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1114958009495 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1114958009496 putative active site [active] 1114958009497 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1114958009498 dimer interface [polypeptide binding]; other site 1114958009499 active site 1114958009500 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1114958009501 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1114958009502 GIY-YIG motif/motif A; other site 1114958009503 active site 1114958009504 catalytic site [active] 1114958009505 putative DNA binding site [nucleotide binding]; other site 1114958009506 metal binding site [ion binding]; metal-binding site 1114958009507 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1114958009508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958009509 S-adenosylmethionine binding site [chemical binding]; other site 1114958009510 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1114958009511 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1114958009512 chitosan binding site [chemical binding]; other site 1114958009513 catalytic residues [active] 1114958009514 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1114958009515 FeS assembly protein SufB; Region: sufB; TIGR01980 1114958009516 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1114958009517 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1114958009518 trimerization site [polypeptide binding]; other site 1114958009519 active site 1114958009520 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1114958009521 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1114958009522 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958009523 catalytic residue [active] 1114958009524 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1114958009525 FeS assembly protein SufD; Region: sufD; TIGR01981 1114958009526 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1114958009527 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1114958009528 Walker A/P-loop; other site 1114958009529 ATP binding site [chemical binding]; other site 1114958009530 Q-loop/lid; other site 1114958009531 ABC transporter signature motif; other site 1114958009532 Walker B; other site 1114958009533 D-loop; other site 1114958009534 H-loop/switch region; other site 1114958009535 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1114958009536 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1114958009537 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1114958009538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009539 ABC-ATPase subunit interface; other site 1114958009540 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1114958009541 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1114958009542 Walker A/P-loop; other site 1114958009543 ATP binding site [chemical binding]; other site 1114958009544 Q-loop/lid; other site 1114958009545 ABC transporter signature motif; other site 1114958009546 Walker B; other site 1114958009547 D-loop; other site 1114958009548 H-loop/switch region; other site 1114958009549 NIL domain; Region: NIL; pfam09383 1114958009550 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1114958009551 catalytic residues [active] 1114958009552 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1114958009553 putative active site [active] 1114958009554 putative metal binding site [ion binding]; other site 1114958009555 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1114958009556 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1114958009557 lipoyl attachment site [posttranslational modification]; other site 1114958009558 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1114958009559 ArsC family; Region: ArsC; pfam03960 1114958009560 putative ArsC-like catalytic residues; other site 1114958009561 putative TRX-like catalytic residues [active] 1114958009562 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1114958009563 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1114958009564 active site 1114958009565 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1114958009566 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1114958009567 dimer interface [polypeptide binding]; other site 1114958009568 active site 1114958009569 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1114958009570 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1114958009571 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114958009572 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1114958009573 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1114958009574 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1114958009575 substrate binding site [chemical binding]; other site 1114958009576 oxyanion hole (OAH) forming residues; other site 1114958009577 trimer interface [polypeptide binding]; other site 1114958009578 YuzL-like protein; Region: YuzL; pfam14115 1114958009579 Proline dehydrogenase; Region: Pro_dh; cl03282 1114958009580 Coat F domain; Region: Coat_F; pfam07875 1114958009581 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958009582 MarR family; Region: MarR; pfam01047 1114958009583 MarR family; Region: MarR_2; cl17246 1114958009584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958009586 putative substrate translocation pore; other site 1114958009587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009588 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958009589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958009590 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958009591 dimerization interface [polypeptide binding]; other site 1114958009592 acetoacetate decarboxylase; Provisional; Region: PRK02265 1114958009593 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1114958009594 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1114958009595 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1114958009596 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1114958009597 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114958009598 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114958009599 Walker A/P-loop; other site 1114958009600 ATP binding site [chemical binding]; other site 1114958009601 Q-loop/lid; other site 1114958009602 ABC transporter signature motif; other site 1114958009603 Walker B; other site 1114958009604 D-loop; other site 1114958009605 H-loop/switch region; other site 1114958009606 YusW-like protein; Region: YusW; pfam14039 1114958009607 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1114958009608 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1114958009609 active site 1114958009610 Zn binding site [ion binding]; other site 1114958009611 short chain dehydrogenase; Provisional; Region: PRK06914 1114958009612 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1114958009613 NADP binding site [chemical binding]; other site 1114958009614 active site 1114958009615 steroid binding site; other site 1114958009616 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1114958009617 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1114958009618 dimerization interface [polypeptide binding]; other site 1114958009619 DPS ferroxidase diiron center [ion binding]; other site 1114958009620 ion pore; other site 1114958009621 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1114958009622 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1114958009623 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114958009624 protein binding site [polypeptide binding]; other site 1114958009625 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958009626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958009627 active site 1114958009628 phosphorylation site [posttranslational modification] 1114958009629 intermolecular recognition site; other site 1114958009630 dimerization interface [polypeptide binding]; other site 1114958009631 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958009632 DNA binding site [nucleotide binding] 1114958009633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958009634 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958009635 dimerization interface [polypeptide binding]; other site 1114958009636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958009637 dimer interface [polypeptide binding]; other site 1114958009638 phosphorylation site [posttranslational modification] 1114958009639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958009640 ATP binding site [chemical binding]; other site 1114958009641 Mg2+ binding site [ion binding]; other site 1114958009642 G-X-G motif; other site 1114958009643 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958009644 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958009645 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1114958009646 Class II fumarases; Region: Fumarase_classII; cd01362 1114958009647 active site 1114958009648 tetramer interface [polypeptide binding]; other site 1114958009649 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1114958009650 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1114958009651 Spore germination protein; Region: Spore_permease; pfam03845 1114958009652 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1114958009653 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1114958009654 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114958009655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958009656 active site 1114958009657 phosphorylation site [posttranslational modification] 1114958009658 intermolecular recognition site; other site 1114958009659 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958009660 DNA binding residues [nucleotide binding] 1114958009661 dimerization interface [polypeptide binding]; other site 1114958009662 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114958009663 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958009664 dimerization interface [polypeptide binding]; other site 1114958009665 Histidine kinase; Region: HisKA_3; pfam07730 1114958009666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958009667 ATP binding site [chemical binding]; other site 1114958009668 Mg2+ binding site [ion binding]; other site 1114958009669 G-X-G motif; other site 1114958009670 Predicted membrane protein [Function unknown]; Region: COG4758 1114958009671 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1114958009672 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1114958009673 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1114958009674 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1114958009675 PspA/IM30 family; Region: PspA_IM30; pfam04012 1114958009676 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1114958009677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009678 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114958009679 putative substrate translocation pore; other site 1114958009680 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1114958009681 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114958009682 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114958009683 Walker A/P-loop; other site 1114958009684 ATP binding site [chemical binding]; other site 1114958009685 Q-loop/lid; other site 1114958009686 ABC transporter signature motif; other site 1114958009687 Walker B; other site 1114958009688 D-loop; other site 1114958009689 H-loop/switch region; other site 1114958009690 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 1114958009691 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1114958009692 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958009693 ABC-ATPase subunit interface; other site 1114958009694 dimer interface [polypeptide binding]; other site 1114958009695 putative PBP binding regions; other site 1114958009696 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1114958009697 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1114958009698 putative binding site residues; other site 1114958009699 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114958009700 classical (c) SDRs; Region: SDR_c; cd05233 1114958009701 NAD(P) binding site [chemical binding]; other site 1114958009702 active site 1114958009703 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1114958009704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958009705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958009706 dimer interface [polypeptide binding]; other site 1114958009707 phosphorylation site [posttranslational modification] 1114958009708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958009709 ATP binding site [chemical binding]; other site 1114958009710 Mg2+ binding site [ion binding]; other site 1114958009711 G-X-G motif; other site 1114958009712 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958009713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958009714 active site 1114958009715 phosphorylation site [posttranslational modification] 1114958009716 intermolecular recognition site; other site 1114958009717 dimerization interface [polypeptide binding]; other site 1114958009718 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958009719 DNA binding site [nucleotide binding] 1114958009720 hypothetical protein; Provisional; Region: PRK14082 1114958009721 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1114958009722 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1114958009723 DNA binding residues [nucleotide binding] 1114958009724 YvrJ protein family; Region: YvrJ; pfam12841 1114958009725 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1114958009726 Cupin; Region: Cupin_1; smart00835 1114958009727 Cupin; Region: Cupin_1; smart00835 1114958009728 Regulatory protein YrvL; Region: YrvL; pfam14184 1114958009729 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1114958009730 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1114958009731 Walker A/P-loop; other site 1114958009732 ATP binding site [chemical binding]; other site 1114958009733 Q-loop/lid; other site 1114958009734 ABC transporter signature motif; other site 1114958009735 Walker B; other site 1114958009736 D-loop; other site 1114958009737 H-loop/switch region; other site 1114958009738 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1114958009739 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958009740 ABC-ATPase subunit interface; other site 1114958009741 dimer interface [polypeptide binding]; other site 1114958009742 putative PBP binding regions; other site 1114958009743 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114958009744 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958009745 ABC-ATPase subunit interface; other site 1114958009746 dimer interface [polypeptide binding]; other site 1114958009747 putative PBP binding regions; other site 1114958009748 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1114958009749 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1114958009750 putative ligand binding residues [chemical binding]; other site 1114958009751 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1114958009752 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1114958009753 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 1114958009754 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; pfam09575 1114958009755 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1114958009756 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1114958009757 Sulfatase; Region: Sulfatase; pfam00884 1114958009758 DNA binding domain, excisionase family; Region: excise; TIGR01764 1114958009759 Periplasmic molybdate-binding protein/domain [Inorganic ion transport and metabolism]; Region: COG1910 1114958009760 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1114958009761 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1114958009762 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1114958009763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009764 dimer interface [polypeptide binding]; other site 1114958009765 conserved gate region; other site 1114958009766 putative PBP binding loops; other site 1114958009767 ABC-ATPase subunit interface; other site 1114958009768 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114958009769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958009770 active site 1114958009771 phosphorylation site [posttranslational modification] 1114958009772 intermolecular recognition site; other site 1114958009773 dimerization interface [polypeptide binding]; other site 1114958009774 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958009775 DNA binding residues [nucleotide binding] 1114958009776 dimerization interface [polypeptide binding]; other site 1114958009777 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114958009778 Histidine kinase; Region: HisKA_3; pfam07730 1114958009779 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1114958009780 Mg2+ binding site [ion binding]; other site 1114958009781 G-X-G motif; other site 1114958009782 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958009783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958009784 Walker A/P-loop; other site 1114958009785 ATP binding site [chemical binding]; other site 1114958009786 Q-loop/lid; other site 1114958009787 ABC transporter signature motif; other site 1114958009788 Walker B; other site 1114958009789 D-loop; other site 1114958009790 H-loop/switch region; other site 1114958009791 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1114958009792 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1114958009793 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1114958009794 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1114958009795 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1114958009796 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958009797 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114958009798 active site 1114958009799 catalytic tetrad [active] 1114958009800 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1114958009801 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1114958009802 sulfite reductase subunit beta; Provisional; Region: PRK13504 1114958009803 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114958009804 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1114958009805 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1114958009806 Flavodoxin; Region: Flavodoxin_1; pfam00258 1114958009807 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1114958009808 FAD binding pocket [chemical binding]; other site 1114958009809 FAD binding motif [chemical binding]; other site 1114958009810 catalytic residues [active] 1114958009811 NAD binding pocket [chemical binding]; other site 1114958009812 phosphate binding motif [ion binding]; other site 1114958009813 beta-alpha-beta structure motif; other site 1114958009814 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1114958009815 Family description; Region: UvrD_C_2; pfam13538 1114958009816 Predicted membrane protein [Function unknown]; Region: COG2860 1114958009817 UPF0126 domain; Region: UPF0126; pfam03458 1114958009818 UPF0126 domain; Region: UPF0126; pfam03458 1114958009819 Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688 1114958009820 active site 1114958009821 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1114958009822 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1114958009823 Thioredoxin; Region: Thioredoxin_4; pfam13462 1114958009824 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114958009825 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114958009826 metal-binding site [ion binding] 1114958009827 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114958009828 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1114958009829 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114958009830 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114958009831 metal-binding site [ion binding] 1114958009832 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114958009833 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114958009834 metal-binding site [ion binding] 1114958009835 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1114958009836 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1114958009837 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1114958009838 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1114958009839 metal-binding site [ion binding] 1114958009840 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1114958009841 putative homodimer interface [polypeptide binding]; other site 1114958009842 putative homotetramer interface [polypeptide binding]; other site 1114958009843 putative allosteric switch controlling residues; other site 1114958009844 putative metal binding site [ion binding]; other site 1114958009845 putative homodimer-homodimer interface [polypeptide binding]; other site 1114958009846 putative oxidoreductase; Provisional; Region: PRK11579 1114958009847 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114958009848 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114958009849 azoreductase; Reviewed; Region: PRK00170 1114958009850 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114958009851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958009852 salt bridge; other site 1114958009853 non-specific DNA binding site [nucleotide binding]; other site 1114958009854 sequence-specific DNA binding site [nucleotide binding]; other site 1114958009855 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114958009856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958009857 putative substrate translocation pore; other site 1114958009858 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1114958009859 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958009860 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1114958009861 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1114958009862 active site 1114958009863 non-prolyl cis peptide bond; other site 1114958009864 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1114958009865 catalytic residues [active] 1114958009866 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1114958009867 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1114958009868 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1114958009869 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1114958009870 Walker A/P-loop; other site 1114958009871 ATP binding site [chemical binding]; other site 1114958009872 Q-loop/lid; other site 1114958009873 ABC transporter signature motif; other site 1114958009874 Walker B; other site 1114958009875 D-loop; other site 1114958009876 H-loop/switch region; other site 1114958009877 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1114958009878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009879 dimer interface [polypeptide binding]; other site 1114958009880 conserved gate region; other site 1114958009881 putative PBP binding loops; other site 1114958009882 ABC-ATPase subunit interface; other site 1114958009883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009884 dimer interface [polypeptide binding]; other site 1114958009885 conserved gate region; other site 1114958009886 putative PBP binding loops; other site 1114958009887 ABC-ATPase subunit interface; other site 1114958009888 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1114958009889 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114958009890 substrate binding pocket [chemical binding]; other site 1114958009891 membrane-bound complex binding site; other site 1114958009892 hinge residues; other site 1114958009893 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1114958009894 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1114958009895 substrate binding pocket [chemical binding]; other site 1114958009896 membrane-bound complex binding site; other site 1114958009897 hinge residues; other site 1114958009898 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1114958009899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958009900 Coenzyme A binding pocket [chemical binding]; other site 1114958009901 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1114958009902 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958009903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958009904 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958009905 dimerization interface [polypeptide binding]; other site 1114958009906 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114958009907 classical (c) SDRs; Region: SDR_c; cd05233 1114958009908 NAD(P) binding site [chemical binding]; other site 1114958009909 active site 1114958009910 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1114958009911 RNAase interaction site [polypeptide binding]; other site 1114958009912 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1114958009913 SmpB-tmRNA interface; other site 1114958009914 ribonuclease R; Region: RNase_R; TIGR02063 1114958009915 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1114958009916 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1114958009917 RNB domain; Region: RNB; pfam00773 1114958009918 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1114958009919 RNA binding site [nucleotide binding]; other site 1114958009920 Esterase/lipase [General function prediction only]; Region: COG1647 1114958009921 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1114958009922 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1114958009923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958009924 salt bridge; other site 1114958009925 non-specific DNA binding site [nucleotide binding]; other site 1114958009926 sequence-specific DNA binding site [nucleotide binding]; other site 1114958009927 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114958009928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958009929 non-specific DNA binding site [nucleotide binding]; other site 1114958009930 salt bridge; other site 1114958009931 sequence-specific DNA binding site [nucleotide binding]; other site 1114958009932 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114958009933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958009934 non-specific DNA binding site [nucleotide binding]; other site 1114958009935 salt bridge; other site 1114958009936 sequence-specific DNA binding site [nucleotide binding]; other site 1114958009937 Predicted transcriptional regulators [Transcription]; Region: COG1733 1114958009938 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1114958009939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958009940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958009941 dimer interface [polypeptide binding]; other site 1114958009942 phosphorylation site [posttranslational modification] 1114958009943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958009944 ATP binding site [chemical binding]; other site 1114958009945 Mg2+ binding site [ion binding]; other site 1114958009946 G-X-G motif; other site 1114958009947 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958009948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958009949 active site 1114958009950 phosphorylation site [posttranslational modification] 1114958009951 intermolecular recognition site; other site 1114958009952 dimerization interface [polypeptide binding]; other site 1114958009953 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958009954 DNA binding site [nucleotide binding] 1114958009955 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1114958009956 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1114958009957 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1114958009958 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1114958009959 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1114958009960 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1114958009961 Walker A/P-loop; other site 1114958009962 ATP binding site [chemical binding]; other site 1114958009963 Q-loop/lid; other site 1114958009964 ABC transporter signature motif; other site 1114958009965 Walker B; other site 1114958009966 D-loop; other site 1114958009967 H-loop/switch region; other site 1114958009968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009969 dimer interface [polypeptide binding]; other site 1114958009970 conserved gate region; other site 1114958009971 putative PBP binding loops; other site 1114958009972 ABC-ATPase subunit interface; other site 1114958009973 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114958009974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009975 dimer interface [polypeptide binding]; other site 1114958009976 conserved gate region; other site 1114958009977 putative PBP binding loops; other site 1114958009978 ABC-ATPase subunit interface; other site 1114958009979 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1114958009980 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1114958009981 Walker A/P-loop; other site 1114958009982 ATP binding site [chemical binding]; other site 1114958009983 Q-loop/lid; other site 1114958009984 ABC transporter signature motif; other site 1114958009985 Walker B; other site 1114958009986 D-loop; other site 1114958009987 H-loop/switch region; other site 1114958009988 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1114958009989 Predicted transcriptional regulators [Transcription]; Region: COG1510 1114958009990 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958009991 putative DNA binding site [nucleotide binding]; other site 1114958009992 putative Zn2+ binding site [ion binding]; other site 1114958009993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958009994 dimer interface [polypeptide binding]; other site 1114958009995 conserved gate region; other site 1114958009996 putative PBP binding loops; other site 1114958009997 ABC-ATPase subunit interface; other site 1114958009998 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1114958009999 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1114958010000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1114958010001 dimer interface [polypeptide binding]; other site 1114958010002 conserved gate region; other site 1114958010003 putative PBP binding loops; other site 1114958010004 ABC-ATPase subunit interface; other site 1114958010005 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1114958010006 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1114958010007 Walker A/P-loop; other site 1114958010008 ATP binding site [chemical binding]; other site 1114958010009 Q-loop/lid; other site 1114958010010 ABC transporter signature motif; other site 1114958010011 Walker B; other site 1114958010012 D-loop; other site 1114958010013 H-loop/switch region; other site 1114958010014 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1114958010015 Predicted transcriptional regulators [Transcription]; Region: COG1510 1114958010016 MarR family; Region: MarR_2; pfam12802 1114958010017 membrane protein, MarC family; Region: TIGR00427 1114958010018 Predicted membrane protein [Function unknown]; Region: COG4640 1114958010019 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1114958010020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958010021 Coenzyme A binding pocket [chemical binding]; other site 1114958010022 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114958010023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010024 putative substrate translocation pore; other site 1114958010025 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1114958010026 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1114958010027 WbqC-like protein family; Region: WbqC; pfam08889 1114958010028 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1114958010029 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1114958010030 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1114958010031 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1114958010032 catalytic residue [active] 1114958010033 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1114958010034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958010035 NAD(P) binding site [chemical binding]; other site 1114958010036 active site 1114958010037 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1114958010038 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1114958010039 inhibitor-cofactor binding pocket; inhibition site 1114958010040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958010041 catalytic residue [active] 1114958010042 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1114958010043 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1114958010044 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114958010045 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1114958010046 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1114958010047 putative integrin binding motif; other site 1114958010048 PA/protease domain interface [polypeptide binding]; other site 1114958010049 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1114958010050 Peptidase family M28; Region: Peptidase_M28; pfam04389 1114958010051 metal binding site [ion binding]; metal-binding site 1114958010052 enolase; Provisional; Region: eno; PRK00077 1114958010053 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1114958010054 dimer interface [polypeptide binding]; other site 1114958010055 metal binding site [ion binding]; metal-binding site 1114958010056 substrate binding pocket [chemical binding]; other site 1114958010057 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1114958010058 phosphoglyceromutase; Provisional; Region: PRK05434 1114958010059 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1114958010060 triosephosphate isomerase; Provisional; Region: PRK14565 1114958010061 substrate binding site [chemical binding]; other site 1114958010062 dimer interface [polypeptide binding]; other site 1114958010063 catalytic triad [active] 1114958010064 Phosphoglycerate kinase; Region: PGK; pfam00162 1114958010065 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1114958010066 substrate binding site [chemical binding]; other site 1114958010067 hinge regions; other site 1114958010068 ADP binding site [chemical binding]; other site 1114958010069 catalytic site [active] 1114958010070 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1114958010071 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1114958010072 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1114958010073 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1114958010074 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1114958010075 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1114958010076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958010078 DNA-binding site [nucleotide binding]; DNA binding site 1114958010079 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958010080 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1114958010081 putative dimerization interface [polypeptide binding]; other site 1114958010082 putative ligand binding site [chemical binding]; other site 1114958010083 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1114958010084 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1114958010085 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1114958010086 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958010087 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958010088 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958010089 dimerization interface [polypeptide binding]; other site 1114958010090 EamA-like transporter family; Region: EamA; pfam00892 1114958010091 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114958010092 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1114958010093 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1114958010094 active site 1114958010095 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958010096 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958010097 DNA binding site [nucleotide binding] 1114958010098 domain linker motif; other site 1114958010099 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1114958010100 putative ligand binding site [chemical binding]; other site 1114958010101 putative dimerization interface [polypeptide binding]; other site 1114958010102 Predicted membrane protein [Function unknown]; Region: COG2364 1114958010103 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958010104 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958010105 active site 1114958010106 motif I; other site 1114958010107 motif II; other site 1114958010108 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958010109 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1114958010110 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1114958010111 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1114958010112 putative active site [active] 1114958010113 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1114958010114 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1114958010115 N- and C-terminal domain interface [polypeptide binding]; other site 1114958010116 active site 1114958010117 catalytic site [active] 1114958010118 metal binding site [ion binding]; metal-binding site 1114958010119 carbohydrate binding site [chemical binding]; other site 1114958010120 ATP binding site [chemical binding]; other site 1114958010121 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1114958010122 GntP family permease; Region: GntP_permease; pfam02447 1114958010123 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1114958010124 iron-sulfur cluster-binding protein; Region: TIGR00273 1114958010125 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1114958010126 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1114958010127 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1114958010128 Cysteine-rich domain; Region: CCG; pfam02754 1114958010129 Cysteine-rich domain; Region: CCG; pfam02754 1114958010130 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114958010131 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958010132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958010133 homodimer interface [polypeptide binding]; other site 1114958010134 catalytic residue [active] 1114958010135 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1114958010136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958010137 DNA-binding site [nucleotide binding]; DNA binding site 1114958010138 FCD domain; Region: FCD; pfam07729 1114958010139 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1114958010140 L-lactate permease; Region: Lactate_perm; pfam02652 1114958010141 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1114958010142 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1114958010143 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1114958010144 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1114958010145 YvfG protein; Region: YvfG; pfam09628 1114958010146 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1114958010147 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1114958010148 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1114958010149 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1114958010150 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1114958010151 inhibitor-cofactor binding pocket; inhibition site 1114958010152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958010153 catalytic residue [active] 1114958010154 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1114958010155 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1114958010156 putative trimer interface [polypeptide binding]; other site 1114958010157 putative CoA binding site [chemical binding]; other site 1114958010158 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1114958010159 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1114958010160 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1114958010161 putative glycosyl transferase; Provisional; Region: PRK10073 1114958010162 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958010163 active site 1114958010164 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1114958010165 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1114958010166 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1114958010167 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958010168 active site 1114958010169 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114958010170 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1114958010171 putative ADP-binding pocket [chemical binding]; other site 1114958010172 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1114958010173 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1114958010174 active site 1114958010175 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1114958010176 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114958010177 putative ADP-binding pocket [chemical binding]; other site 1114958010178 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1114958010179 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1114958010180 NAD(P) binding site [chemical binding]; other site 1114958010181 homodimer interface [polypeptide binding]; other site 1114958010182 substrate binding site [chemical binding]; other site 1114958010183 active site 1114958010184 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1114958010185 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1114958010186 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1114958010187 Chain length determinant protein; Region: Wzz; cl15801 1114958010188 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114958010189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958010190 non-specific DNA binding site [nucleotide binding]; other site 1114958010191 salt bridge; other site 1114958010192 sequence-specific DNA binding site [nucleotide binding]; other site 1114958010193 Anti-repressor SinI; Region: SinI; pfam08671 1114958010194 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1114958010195 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1114958010196 substrate binding pocket [chemical binding]; other site 1114958010197 catalytic triad [active] 1114958010198 RibD C-terminal domain; Region: RibD_C; cl17279 1114958010199 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1114958010200 Predicted membrane protein [Function unknown]; Region: COG2364 1114958010201 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114958010202 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958010203 Coenzyme A binding pocket [chemical binding]; other site 1114958010204 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1114958010205 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 1114958010206 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1114958010207 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1114958010208 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1114958010209 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1114958010210 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1114958010211 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1114958010212 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1114958010213 substrate binding [chemical binding]; other site 1114958010214 active site 1114958010215 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1114958010216 galactoside permease; Reviewed; Region: lacY; PRK09528 1114958010217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010218 putative substrate translocation pore; other site 1114958010219 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958010220 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958010221 DNA binding site [nucleotide binding] 1114958010222 domain linker motif; other site 1114958010223 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1114958010224 dimerization interface [polypeptide binding]; other site 1114958010225 ligand binding site [chemical binding]; other site 1114958010226 sodium binding site [ion binding]; other site 1114958010227 Clp protease; Region: CLP_protease; pfam00574 1114958010228 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1114958010229 oligomer interface [polypeptide binding]; other site 1114958010230 active site residues [active] 1114958010231 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958010232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958010233 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958010234 dimerization interface [polypeptide binding]; other site 1114958010235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 1114958010236 benzoate transport; Region: 2A0115; TIGR00895 1114958010237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010238 putative substrate translocation pore; other site 1114958010239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010240 TIGR00730 family protein; Region: TIGR00730 1114958010241 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1114958010242 metal binding site [ion binding]; metal-binding site 1114958010243 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1114958010244 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1114958010245 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1114958010246 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1114958010247 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1114958010248 active site clefts [active] 1114958010249 zinc binding site [ion binding]; other site 1114958010250 dimer interface [polypeptide binding]; other site 1114958010251 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1114958010252 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1114958010253 dimerization interface [polypeptide binding]; other site 1114958010254 ligand binding site [chemical binding]; other site 1114958010255 NADP binding site [chemical binding]; other site 1114958010256 catalytic site [active] 1114958010257 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 1114958010258 active site 1114958010259 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1114958010260 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1114958010261 dimerization domain swap beta strand [polypeptide binding]; other site 1114958010262 regulatory protein interface [polypeptide binding]; other site 1114958010263 active site 1114958010264 regulatory phosphorylation site [posttranslational modification]; other site 1114958010265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1114958010266 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1114958010267 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1114958010268 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1114958010269 phosphate binding site [ion binding]; other site 1114958010270 putative substrate binding pocket [chemical binding]; other site 1114958010271 dimer interface [polypeptide binding]; other site 1114958010272 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1114958010273 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1114958010274 putative active site [active] 1114958010275 nucleotide binding site [chemical binding]; other site 1114958010276 nudix motif; other site 1114958010277 putative metal binding site [ion binding]; other site 1114958010278 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1114958010279 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114958010280 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958010281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1114958010282 GDP/GTP exchange factor Sec2p; Region: Sec2p; pfam06428 1114958010283 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1114958010284 NlpC/P60 family; Region: NLPC_P60; pfam00877 1114958010285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958010286 binding surface 1114958010287 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1114958010288 TPR motif; other site 1114958010289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958010290 TPR motif; other site 1114958010291 binding surface 1114958010292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958010293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958010294 dimer interface [polypeptide binding]; other site 1114958010295 phosphorylation site [posttranslational modification] 1114958010296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958010297 ATP binding site [chemical binding]; other site 1114958010298 Mg2+ binding site [ion binding]; other site 1114958010299 G-X-G motif; other site 1114958010300 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958010301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958010302 active site 1114958010303 phosphorylation site [posttranslational modification] 1114958010304 intermolecular recognition site; other site 1114958010305 dimerization interface [polypeptide binding]; other site 1114958010306 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958010307 DNA binding site [nucleotide binding] 1114958010308 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114958010309 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114958010310 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958010311 Walker A/P-loop; other site 1114958010312 ATP binding site [chemical binding]; other site 1114958010313 Q-loop/lid; other site 1114958010314 ABC transporter signature motif; other site 1114958010315 Walker B; other site 1114958010316 D-loop; other site 1114958010317 H-loop/switch region; other site 1114958010318 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1114958010319 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1114958010320 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1114958010321 metal binding site [ion binding]; metal-binding site 1114958010322 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1114958010323 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1114958010324 substrate binding site [chemical binding]; other site 1114958010325 glutamase interaction surface [polypeptide binding]; other site 1114958010326 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1114958010327 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1114958010328 catalytic residues [active] 1114958010329 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1114958010330 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1114958010331 putative active site [active] 1114958010332 oxyanion strand; other site 1114958010333 catalytic triad [active] 1114958010334 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1114958010335 putative active site pocket [active] 1114958010336 4-fold oligomerization interface [polypeptide binding]; other site 1114958010337 metal binding residues [ion binding]; metal-binding site 1114958010338 3-fold/trimer interface [polypeptide binding]; other site 1114958010339 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1114958010340 histidinol dehydrogenase; Region: hisD; TIGR00069 1114958010341 NAD binding site [chemical binding]; other site 1114958010342 dimerization interface [polypeptide binding]; other site 1114958010343 product binding site; other site 1114958010344 substrate binding site [chemical binding]; other site 1114958010345 zinc binding site [ion binding]; other site 1114958010346 catalytic residues [active] 1114958010347 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1114958010348 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1114958010349 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1114958010350 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1114958010351 dimer interface [polypeptide binding]; other site 1114958010352 motif 1; other site 1114958010353 active site 1114958010354 motif 2; other site 1114958010355 motif 3; other site 1114958010356 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1114958010357 putative active site [active] 1114958010358 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1114958010359 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1114958010360 trimer interface [polypeptide binding]; other site 1114958010361 active site 1114958010362 substrate binding site [chemical binding]; other site 1114958010363 CoA binding site [chemical binding]; other site 1114958010364 pyrophosphatase PpaX; Provisional; Region: PRK13288 1114958010365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958010366 active site 1114958010367 motif I; other site 1114958010368 motif II; other site 1114958010369 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1114958010370 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1114958010371 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1114958010372 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1114958010373 Hpr binding site; other site 1114958010374 active site 1114958010375 homohexamer subunit interaction site [polypeptide binding]; other site 1114958010376 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1114958010377 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1114958010378 active site 1114958010379 dimer interface [polypeptide binding]; other site 1114958010380 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1114958010381 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1114958010382 active site 1114958010383 trimer interface [polypeptide binding]; other site 1114958010384 allosteric site; other site 1114958010385 active site lid [active] 1114958010386 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1114958010387 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1114958010388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958010389 DNA-binding site [nucleotide binding]; DNA binding site 1114958010390 UTRA domain; Region: UTRA; pfam07702 1114958010391 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958010392 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958010393 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1114958010394 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1114958010395 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1114958010396 putative active site [active] 1114958010397 putative metal binding site [ion binding]; other site 1114958010398 Predicted membrane protein [Function unknown]; Region: COG1950 1114958010399 PspC domain; Region: PspC; pfam04024 1114958010400 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1114958010401 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1114958010402 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1114958010403 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1114958010404 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1114958010405 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1114958010406 excinuclease ABC subunit B; Provisional; Region: PRK05298 1114958010407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958010408 ATP binding site [chemical binding]; other site 1114958010409 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958010410 nucleotide binding region [chemical binding]; other site 1114958010411 ATP-binding site [chemical binding]; other site 1114958010412 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1114958010413 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; pfam09964 1114958010414 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1114958010415 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1114958010416 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1114958010417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958010418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958010419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010420 putative substrate translocation pore; other site 1114958010421 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1114958010422 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114958010423 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114958010424 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114958010425 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114958010426 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1114958010427 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1114958010428 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114958010429 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1114958010430 C-terminal peptidase (prc); Region: prc; TIGR00225 1114958010431 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1114958010432 protein binding site [polypeptide binding]; other site 1114958010433 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1114958010434 Catalytic dyad [active] 1114958010435 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1114958010436 Right handed beta helix region; Region: Beta_helix; pfam13229 1114958010437 Right handed beta helix region; Region: Beta_helix; pfam13229 1114958010438 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1114958010439 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1114958010440 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1114958010441 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958010442 Walker A/P-loop; other site 1114958010443 ATP binding site [chemical binding]; other site 1114958010444 Q-loop/lid; other site 1114958010445 ABC transporter signature motif; other site 1114958010446 Walker B; other site 1114958010447 D-loop; other site 1114958010448 H-loop/switch region; other site 1114958010449 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1114958010450 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1114958010451 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958010452 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958010453 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958010454 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1114958010455 peptide chain release factor 2; Provisional; Region: PRK06746 1114958010456 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1114958010457 RF-1 domain; Region: RF-1; pfam00472 1114958010458 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1114958010459 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1114958010460 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1114958010461 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1114958010462 nucleotide binding region [chemical binding]; other site 1114958010463 ATP-binding site [chemical binding]; other site 1114958010464 SEC-C motif; Region: SEC-C; pfam02810 1114958010465 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1114958010466 30S subunit binding site; other site 1114958010467 Flagellar protein FliT; Region: FliT; pfam05400 1114958010468 flagellar protein FliS; Validated; Region: fliS; PRK05685 1114958010469 flagellar capping protein; Validated; Region: fliD; PRK07737 1114958010470 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1114958010471 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1114958010472 flagellin; Provisional; Region: PRK12804 1114958010473 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1114958010474 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1114958010475 carbon storage regulator; Provisional; Region: PRK01712 1114958010476 flagellar assembly protein FliW; Provisional; Region: PRK13285 1114958010477 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1114958010478 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1114958010479 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1114958010480 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1114958010481 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1114958010482 FlgN protein; Region: FlgN; pfam05130 1114958010483 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1114958010484 flagellar operon protein TIGR03826; Region: YvyF 1114958010485 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958010486 active site 1114958010487 Late competence development protein ComFB; Region: ComFB; pfam10719 1114958010488 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1114958010489 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958010490 ATP binding site [chemical binding]; other site 1114958010491 putative Mg++ binding site [ion binding]; other site 1114958010492 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958010493 nucleotide binding region [chemical binding]; other site 1114958010494 ATP-binding site [chemical binding]; other site 1114958010495 EDD domain protein, DegV family; Region: DegV; TIGR00762 1114958010496 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1114958010497 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114958010498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958010499 active site 1114958010500 phosphorylation site [posttranslational modification] 1114958010501 intermolecular recognition site; other site 1114958010502 dimerization interface [polypeptide binding]; other site 1114958010503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958010504 DNA binding residues [nucleotide binding] 1114958010505 dimerization interface [polypeptide binding]; other site 1114958010506 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114958010507 Histidine kinase; Region: HisKA_3; pfam07730 1114958010508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958010509 ATP binding site [chemical binding]; other site 1114958010510 Mg2+ binding site [ion binding]; other site 1114958010511 G-X-G motif; other site 1114958010512 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1114958010513 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1114958010514 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1114958010515 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1114958010516 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1114958010517 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1114958010518 Mg++ binding site [ion binding]; other site 1114958010519 putative catalytic motif [active] 1114958010520 substrate binding site [chemical binding]; other site 1114958010521 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1114958010522 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114958010523 putative homodimer interface [polypeptide binding]; other site 1114958010524 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1114958010525 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958010526 active site 1114958010527 O-Antigen ligase; Region: Wzy_C; pfam04932 1114958010528 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1114958010529 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1114958010530 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114958010531 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1114958010532 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114958010533 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1114958010534 colanic acid exporter; Provisional; Region: PRK10459 1114958010535 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1114958010536 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1114958010537 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1114958010538 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1114958010539 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1114958010540 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1114958010541 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1114958010542 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1114958010543 active site 1114958010544 metal binding site [ion binding]; metal-binding site 1114958010545 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1114958010546 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1114958010547 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1114958010548 Stage II sporulation protein; Region: SpoIID; pfam08486 1114958010549 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1114958010550 Entericidin EcnA/B family; Region: Entericidin; cl02322 1114958010551 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 1114958010552 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1114958010553 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1114958010554 active site 1114958010555 homodimer interface [polypeptide binding]; other site 1114958010556 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1114958010557 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1114958010558 active site 1114958010559 tetramer interface; other site 1114958010560 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1114958010561 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1114958010562 Walker A/P-loop; other site 1114958010563 ATP binding site [chemical binding]; other site 1114958010564 Q-loop/lid; other site 1114958010565 ABC transporter signature motif; other site 1114958010566 Walker B; other site 1114958010567 D-loop; other site 1114958010568 H-loop/switch region; other site 1114958010569 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1114958010570 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1114958010571 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1114958010572 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1114958010573 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958010574 active site 1114958010575 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1114958010576 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1114958010577 active site 1114958010578 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1114958010579 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1114958010580 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1114958010581 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1114958010582 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1114958010583 Bacterial SH3 domain; Region: SH3_3; pfam08239 1114958010584 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 1114958010585 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1114958010586 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1114958010587 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1114958010588 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1114958010589 Spore germination protein; Region: Spore_permease; pfam03845 1114958010590 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1114958010591 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1114958010592 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1114958010593 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1114958010594 Probable Catalytic site; other site 1114958010595 metal-binding site 1114958010596 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1114958010597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958010598 S-adenosylmethionine binding site [chemical binding]; other site 1114958010599 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1114958010600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010601 putative substrate translocation pore; other site 1114958010602 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1114958010603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958010604 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958010605 active site 1114958010606 motif I; other site 1114958010607 motif II; other site 1114958010608 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1114958010609 Septum formation initiator; Region: DivIC; cl17659 1114958010610 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1114958010611 NlpC/P60 family; Region: NLPC_P60; pfam00877 1114958010612 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1114958010613 NlpC/P60 family; Region: NLPC_P60; pfam00877 1114958010614 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1114958010615 NlpC/P60 family; Region: NLPC_P60; pfam00877 1114958010616 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1114958010617 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1114958010618 putative active site [active] 1114958010619 putative metal binding site [ion binding]; other site 1114958010620 poly-gamma-glutamate biosynthesis protein PgsC/CapC; Region: poly_gGlu_PgsC; TIGR04011 1114958010621 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1114958010622 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1114958010623 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1114958010624 Spore germination protein; Region: Spore_permease; cl17796 1114958010625 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1114958010626 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1114958010627 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958010628 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958010629 DNA binding site [nucleotide binding] 1114958010630 domain linker motif; other site 1114958010631 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1114958010632 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114958010633 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1114958010634 substrate binding site [chemical binding]; other site 1114958010635 dimer interface [polypeptide binding]; other site 1114958010636 ATP binding site [chemical binding]; other site 1114958010637 D-ribose pyranase; Provisional; Region: PRK11797 1114958010638 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1114958010639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958010640 Walker A/P-loop; other site 1114958010641 ATP binding site [chemical binding]; other site 1114958010642 Q-loop/lid; other site 1114958010643 ABC transporter signature motif; other site 1114958010644 Walker B; other site 1114958010645 D-loop; other site 1114958010646 H-loop/switch region; other site 1114958010647 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1114958010648 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1114958010649 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1114958010650 TM-ABC transporter signature motif; other site 1114958010651 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1114958010652 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1114958010653 ligand binding site [chemical binding]; other site 1114958010654 dimerization interface [polypeptide binding]; other site 1114958010655 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1114958010656 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1114958010657 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 1114958010658 acetolactate synthase; Reviewed; Region: PRK08617 1114958010659 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114958010660 PYR/PP interface [polypeptide binding]; other site 1114958010661 dimer interface [polypeptide binding]; other site 1114958010662 TPP binding site [chemical binding]; other site 1114958010663 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1114958010664 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1114958010665 TPP-binding site [chemical binding]; other site 1114958010666 dimer interface [polypeptide binding]; other site 1114958010667 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1114958010668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958010669 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1114958010670 putative dimerization interface [polypeptide binding]; other site 1114958010671 putative substrate binding pocket [chemical binding]; other site 1114958010672 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1114958010673 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1114958010674 transmembrane helices; other site 1114958010675 CotH protein; Region: CotH; pfam08757 1114958010676 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1114958010677 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1114958010678 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1114958010679 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1114958010680 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1114958010681 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958010682 putative DNA binding site [nucleotide binding]; other site 1114958010683 putative Zn2+ binding site [ion binding]; other site 1114958010684 AsnC family; Region: AsnC_trans_reg; pfam01037 1114958010685 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1114958010686 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1114958010687 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1114958010688 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1114958010689 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958010690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958010691 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1114958010692 dimerization interface [polypeptide binding]; other site 1114958010693 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1114958010694 Active_site [active] 1114958010695 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1114958010696 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1114958010697 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1114958010698 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 1114958010699 LXG domain of WXG superfamily; Region: LXG; pfam04740 1114958010700 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1114958010701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1114958010702 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1114958010703 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1114958010704 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1114958010705 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1114958010706 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1114958010707 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1114958010708 active site 1114958010709 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1114958010710 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1114958010711 Nucleotide binding site [chemical binding]; other site 1114958010712 DTAP/Switch II; other site 1114958010713 Switch I; other site 1114958010714 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1114958010715 Chain length determinant protein; Region: Wzz; cl15801 1114958010716 SWIM zinc finger; Region: SWIM; pfam04434 1114958010717 SNF2 Helicase protein; Region: DUF3670; pfam12419 1114958010718 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1114958010719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958010720 ATP binding site [chemical binding]; other site 1114958010721 putative Mg++ binding site [ion binding]; other site 1114958010722 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1114958010723 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958010724 nucleotide binding region [chemical binding]; other site 1114958010725 ATP-binding site [chemical binding]; other site 1114958010726 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958010727 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1114958010728 active site 1114958010729 motif I; other site 1114958010730 motif II; other site 1114958010731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958010732 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114958010733 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1114958010734 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114958010735 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1114958010736 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1114958010737 dimer interface [polypeptide binding]; other site 1114958010738 ssDNA binding site [nucleotide binding]; other site 1114958010739 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114958010740 YwpF-like protein; Region: YwpF; pfam14183 1114958010741 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 1114958010742 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1114958010743 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1114958010744 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958010745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958010746 binding surface 1114958010747 TPR motif; other site 1114958010748 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958010749 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1114958010750 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1114958010751 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1114958010752 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1114958010753 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1114958010754 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1114958010755 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1114958010756 MreB and similar proteins; Region: MreB_like; cd10225 1114958010757 nucleotide binding site [chemical binding]; other site 1114958010758 Mg binding site [ion binding]; other site 1114958010759 putative protofilament interaction site [polypeptide binding]; other site 1114958010760 RodZ interaction site [polypeptide binding]; other site 1114958010761 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1114958010762 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958010763 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958010764 putative Zn2+ binding site [ion binding]; other site 1114958010765 putative DNA binding site [nucleotide binding]; other site 1114958010766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010767 putative substrate translocation pore; other site 1114958010768 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958010769 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1114958010770 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1114958010771 Na binding site [ion binding]; other site 1114958010772 putative substrate binding site [chemical binding]; other site 1114958010773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010774 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958010775 putative substrate translocation pore; other site 1114958010776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958010777 Isochorismatase family; Region: Isochorismatase; pfam00857 1114958010778 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1114958010779 catalytic triad [active] 1114958010780 conserved cis-peptide bond; other site 1114958010781 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1114958010782 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1114958010783 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1114958010784 cell division protein FtsW; Region: ftsW; TIGR02614 1114958010785 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1114958010786 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1114958010787 active site 1114958010788 VanZ like family; Region: VanZ; pfam04892 1114958010789 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1114958010790 Peptidase family M23; Region: Peptidase_M23; pfam01551 1114958010791 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1114958010792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958010793 Coenzyme A binding pocket [chemical binding]; other site 1114958010794 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1114958010795 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1114958010796 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1114958010797 putative active site [active] 1114958010798 catalytic site [active] 1114958010799 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1114958010800 putative active site [active] 1114958010801 catalytic site [active] 1114958010802 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1114958010803 Predicted transcriptional regulator [Transcription]; Region: COG1959 1114958010804 Transcriptional regulator; Region: Rrf2; pfam02082 1114958010805 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1114958010806 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1114958010807 subunit interactions [polypeptide binding]; other site 1114958010808 active site 1114958010809 flap region; other site 1114958010810 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1114958010811 gamma-beta subunit interface [polypeptide binding]; other site 1114958010812 alpha-beta subunit interface [polypeptide binding]; other site 1114958010813 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1114958010814 alpha-gamma subunit interface [polypeptide binding]; other site 1114958010815 beta-gamma subunit interface [polypeptide binding]; other site 1114958010816 CsbD-like; Region: CsbD; cl17424 1114958010817 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958010818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958010819 binding surface 1114958010820 TPR motif; other site 1114958010821 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1114958010822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1114958010823 FeS/SAM binding site; other site 1114958010824 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1114958010825 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1114958010826 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1114958010827 metal ion-dependent adhesion site (MIDAS); other site 1114958010828 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1114958010829 metal ion-dependent adhesion site (MIDAS); other site 1114958010830 Stage II sporulation protein; Region: SpoIID; pfam08486 1114958010831 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1114958010832 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1114958010833 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1114958010834 hinge; other site 1114958010835 active site 1114958010836 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1114958010837 Predicted membrane protein [Function unknown]; Region: COG4836 1114958010838 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1114958010839 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1114958010840 gamma subunit interface [polypeptide binding]; other site 1114958010841 epsilon subunit interface [polypeptide binding]; other site 1114958010842 LBP interface [polypeptide binding]; other site 1114958010843 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1114958010844 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1114958010845 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1114958010846 alpha subunit interaction interface [polypeptide binding]; other site 1114958010847 Walker A motif; other site 1114958010848 ATP binding site [chemical binding]; other site 1114958010849 Walker B motif; other site 1114958010850 inhibitor binding site; inhibition site 1114958010851 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1114958010852 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1114958010853 core domain interface [polypeptide binding]; other site 1114958010854 delta subunit interface [polypeptide binding]; other site 1114958010855 epsilon subunit interface [polypeptide binding]; other site 1114958010856 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1114958010857 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1114958010858 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1114958010859 beta subunit interaction interface [polypeptide binding]; other site 1114958010860 Walker A motif; other site 1114958010861 ATP binding site [chemical binding]; other site 1114958010862 Walker B motif; other site 1114958010863 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1114958010864 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 1114958010865 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1114958010866 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1114958010867 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1114958010868 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1114958010869 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1114958010870 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1114958010871 ATP synthase I chain; Region: ATP_synt_I; pfam03899 1114958010872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1114958010873 active site 1114958010874 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1114958010875 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1114958010876 dimer interface [polypeptide binding]; other site 1114958010877 active site 1114958010878 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1114958010879 folate binding site [chemical binding]; other site 1114958010880 hypothetical protein; Provisional; Region: PRK13690 1114958010881 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1114958010882 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1114958010883 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1114958010884 active site 1114958010885 Predicted membrane protein [Function unknown]; Region: COG1971 1114958010886 Domain of unknown function DUF; Region: DUF204; pfam02659 1114958010887 Domain of unknown function DUF; Region: DUF204; pfam02659 1114958010888 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1114958010889 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1114958010890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114958010891 stage II sporulation protein R; Region: spore_II_R; TIGR02837 1114958010892 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1114958010893 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958010894 S-adenosylmethionine binding site [chemical binding]; other site 1114958010895 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1114958010896 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1114958010897 RF-1 domain; Region: RF-1; pfam00472 1114958010898 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1114958010899 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958010900 putative metal binding site [ion binding]; other site 1114958010901 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1114958010902 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1114958010903 DNA binding residues [nucleotide binding] 1114958010904 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 1114958010905 malate dehydrogenase; Provisional; Region: PRK13529 1114958010906 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1114958010907 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1114958010908 NAD(P) binding site [chemical binding]; other site 1114958010909 thymidine kinase; Provisional; Region: PRK04296 1114958010910 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1114958010911 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1114958010912 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1114958010913 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1114958010914 RNA binding site [nucleotide binding]; other site 1114958010915 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1114958010916 multimer interface [polypeptide binding]; other site 1114958010917 Walker A motif; other site 1114958010918 ATP binding site [chemical binding]; other site 1114958010919 Walker B motif; other site 1114958010920 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1114958010921 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1114958010922 putative active site [active] 1114958010923 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1114958010924 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1114958010925 hinge; other site 1114958010926 active site 1114958010927 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1114958010928 active site 1114958010929 intersubunit interactions; other site 1114958010930 catalytic residue [active] 1114958010931 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1114958010932 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1114958010933 intersubunit interface [polypeptide binding]; other site 1114958010934 active site 1114958010935 zinc binding site [ion binding]; other site 1114958010936 Na+ binding site [ion binding]; other site 1114958010937 Response regulator receiver domain; Region: Response_reg; pfam00072 1114958010938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958010939 active site 1114958010940 phosphorylation site [posttranslational modification] 1114958010941 intermolecular recognition site; other site 1114958010942 dimerization interface [polypeptide binding]; other site 1114958010943 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1114958010944 CTP synthetase; Validated; Region: pyrG; PRK05380 1114958010945 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1114958010946 Catalytic site [active] 1114958010947 active site 1114958010948 UTP binding site [chemical binding]; other site 1114958010949 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1114958010950 active site 1114958010951 putative oxyanion hole; other site 1114958010952 catalytic triad [active] 1114958010953 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1114958010954 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 1114958010955 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1114958010956 Cysteine-rich domain; Region: CCG; pfam02754 1114958010957 Cysteine-rich domain; Region: CCG; pfam02754 1114958010958 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1114958010959 PLD-like domain; Region: PLDc_2; pfam13091 1114958010960 putative active site [active] 1114958010961 catalytic site [active] 1114958010962 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1114958010963 PLD-like domain; Region: PLDc_2; pfam13091 1114958010964 putative active site [active] 1114958010965 catalytic site [active] 1114958010966 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 1114958010967 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1114958010968 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114958010969 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1114958010970 Walker A/P-loop; other site 1114958010971 ATP binding site [chemical binding]; other site 1114958010972 Q-loop/lid; other site 1114958010973 ABC transporter signature motif; other site 1114958010974 Walker B; other site 1114958010975 D-loop; other site 1114958010976 H-loop/switch region; other site 1114958010977 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1114958010978 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1114958010979 putative active site [active] 1114958010980 catalytic site [active] 1114958010981 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1114958010982 putative active site [active] 1114958010983 catalytic site [active] 1114958010984 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958010985 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958010986 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1114958010987 nitrate reductase molybdenum cofactor assembly chaperone; Region: narJ; TIGR00684 1114958010988 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1114958010989 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1114958010990 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1114958010991 [4Fe-4S] binding site [ion binding]; other site 1114958010992 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114958010993 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114958010994 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1114958010995 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1114958010996 molybdopterin cofactor binding site; other site 1114958010997 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1114958010998 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1114958010999 ligand binding site [chemical binding]; other site 1114958011000 flexible hinge region; other site 1114958011001 YwiC-like protein; Region: YwiC; pfam14256 1114958011002 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1114958011003 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1114958011004 ligand binding site [chemical binding]; other site 1114958011005 flexible hinge region; other site 1114958011006 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1114958011007 putative switch regulator; other site 1114958011008 non-specific DNA interactions [nucleotide binding]; other site 1114958011009 DNA binding site [nucleotide binding] 1114958011010 sequence specific DNA binding site [nucleotide binding]; other site 1114958011011 putative cAMP binding site [chemical binding]; other site 1114958011012 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1114958011013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011014 putative substrate translocation pore; other site 1114958011015 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1114958011016 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1114958011017 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1114958011018 active site 1114958011019 HIGH motif; other site 1114958011020 KMSK motif region; other site 1114958011021 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1114958011022 tRNA binding surface [nucleotide binding]; other site 1114958011023 anticodon binding site; other site 1114958011024 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1114958011025 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958011026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1114958011027 binding surface 1114958011028 TPR motif; other site 1114958011029 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958011030 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1114958011031 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1114958011032 non-specific DNA binding site [nucleotide binding]; other site 1114958011033 salt bridge; other site 1114958011034 sequence-specific DNA binding site [nucleotide binding]; other site 1114958011035 Integral membrane protein DUF95; Region: DUF95; pfam01944 1114958011036 agmatinase; Region: agmatinase; TIGR01230 1114958011037 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1114958011038 putative active site [active] 1114958011039 Mn binding site [ion binding]; other site 1114958011040 spermidine synthase; Provisional; Region: PRK00811 1114958011041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1114958011042 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1114958011043 Transglycosylase; Region: Transgly; pfam00912 1114958011044 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1114958011045 YwhD family; Region: YwhD; pfam08741 1114958011046 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1114958011047 Peptidase family M50; Region: Peptidase_M50; pfam02163 1114958011048 active site 1114958011049 putative substrate binding region [chemical binding]; other site 1114958011050 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1114958011051 active site 1 [active] 1114958011052 dimer interface [polypeptide binding]; other site 1114958011053 hexamer interface [polypeptide binding]; other site 1114958011054 active site 2 [active] 1114958011055 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958011056 dimerization interface [polypeptide binding]; other site 1114958011057 putative DNA binding site [nucleotide binding]; other site 1114958011058 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958011059 putative Zn2+ binding site [ion binding]; other site 1114958011060 amino acid transporter; Region: 2A0306; TIGR00909 1114958011061 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1114958011062 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1114958011063 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1114958011064 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1114958011065 Zn2+ binding site [ion binding]; other site 1114958011066 Mg2+ binding site [ion binding]; other site 1114958011067 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1114958011068 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1114958011069 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1114958011070 Predicted transcriptional regulators [Transcription]; Region: COG1695 1114958011071 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1114958011072 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1114958011073 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1114958011074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958011075 Walker A/P-loop; other site 1114958011076 ATP binding site [chemical binding]; other site 1114958011077 Q-loop/lid; other site 1114958011078 ABC transporter signature motif; other site 1114958011079 Walker B; other site 1114958011080 D-loop; other site 1114958011081 H-loop/switch region; other site 1114958011082 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1114958011083 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1114958011084 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1114958011085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958011086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958011087 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1114958011088 putative dimerization interface [polypeptide binding]; other site 1114958011089 Predicted membrane protein [Function unknown]; Region: COG2855 1114958011090 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1114958011091 putative heme peroxidase; Provisional; Region: PRK12276 1114958011092 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114958011093 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1114958011094 putative NAD(P) binding site [chemical binding]; other site 1114958011095 putative active site [active] 1114958011096 transaminase; Reviewed; Region: PRK08068 1114958011097 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958011098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958011099 homodimer interface [polypeptide binding]; other site 1114958011100 catalytic residue [active] 1114958011101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011102 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114958011103 putative substrate translocation pore; other site 1114958011104 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1114958011105 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1114958011106 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1114958011107 classical (c) SDRs; Region: SDR_c; cd05233 1114958011108 NAD(P) binding site [chemical binding]; other site 1114958011109 active site 1114958011110 Cupin domain; Region: Cupin_2; pfam07883 1114958011111 Cupin domain; Region: Cupin_2; pfam07883 1114958011112 Prephenate dehydratase; Region: PDT; pfam00800 1114958011113 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114958011114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011115 putative substrate translocation pore; other site 1114958011116 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1114958011117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011118 putative substrate translocation pore; other site 1114958011119 S-methylmethionine transporter; Provisional; Region: PRK11387 1114958011120 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1114958011121 putative metal binding site [ion binding]; other site 1114958011122 putative dimer interface [polypeptide binding]; other site 1114958011123 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1114958011124 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1114958011125 Glutamate binding site [chemical binding]; other site 1114958011126 homodimer interface [polypeptide binding]; other site 1114958011127 NAD binding site [chemical binding]; other site 1114958011128 catalytic residues [active] 1114958011129 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1114958011130 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1114958011131 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1114958011132 NAD(P) binding site [chemical binding]; other site 1114958011133 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1114958011134 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1114958011135 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1114958011136 NADP binding site [chemical binding]; other site 1114958011137 active site 1114958011138 putative substrate binding site [chemical binding]; other site 1114958011139 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1114958011140 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1114958011141 NAD binding site [chemical binding]; other site 1114958011142 substrate binding site [chemical binding]; other site 1114958011143 homodimer interface [polypeptide binding]; other site 1114958011144 active site 1114958011145 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1114958011146 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1114958011147 substrate binding site; other site 1114958011148 tetramer interface; other site 1114958011149 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 1114958011150 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1114958011151 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1114958011152 ligand binding site; other site 1114958011153 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1114958011154 NeuB family; Region: NeuB; pfam03102 1114958011155 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1114958011156 NeuB binding interface [polypeptide binding]; other site 1114958011157 putative substrate binding site [chemical binding]; other site 1114958011158 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1114958011159 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958011160 Coenzyme A binding pocket [chemical binding]; other site 1114958011161 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1114958011162 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1114958011163 inhibitor-cofactor binding pocket; inhibition site 1114958011164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958011165 catalytic residue [active] 1114958011166 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1114958011167 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1114958011168 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958011169 active site 1114958011170 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1114958011171 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1114958011172 Permease family; Region: Xan_ur_permease; pfam00860 1114958011173 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1114958011174 ligand binding site [chemical binding]; other site 1114958011175 active site 1114958011176 UGI interface [polypeptide binding]; other site 1114958011177 catalytic site [active] 1114958011178 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1114958011179 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1114958011180 active site 1114958011181 Predicted transcriptional regulators [Transcription]; Region: COG1695 1114958011182 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1114958011183 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1114958011184 dimer interface [polypeptide binding]; other site 1114958011185 substrate binding site [chemical binding]; other site 1114958011186 ATP binding site [chemical binding]; other site 1114958011187 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1114958011188 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1114958011189 substrate binding [chemical binding]; other site 1114958011190 active site 1114958011191 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1114958011192 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1114958011193 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1114958011194 active site turn [active] 1114958011195 phosphorylation site [posttranslational modification] 1114958011196 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1114958011197 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1114958011198 CAT RNA binding domain; Region: CAT_RBD; smart01061 1114958011199 PRD domain; Region: PRD; pfam00874 1114958011200 PRD domain; Region: PRD; pfam00874 1114958011201 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1114958011202 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1114958011203 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1114958011204 putative active site [active] 1114958011205 catalytic triad [active] 1114958011206 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1114958011207 PA/protease domain interface [polypeptide binding]; other site 1114958011208 putative integrin binding motif; other site 1114958011209 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1114958011210 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1114958011211 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1114958011212 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1114958011213 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1114958011214 dimer interface [polypeptide binding]; other site 1114958011215 FMN binding site [chemical binding]; other site 1114958011216 NADPH bind site [chemical binding]; other site 1114958011217 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 1114958011218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958011219 Coenzyme A binding pocket [chemical binding]; other site 1114958011220 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 1114958011221 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1114958011222 Subunit I/III interface [polypeptide binding]; other site 1114958011223 Subunit III/IV interface [polypeptide binding]; other site 1114958011224 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1114958011225 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1114958011226 D-pathway; other site 1114958011227 Putative ubiquinol binding site [chemical binding]; other site 1114958011228 Low-spin heme (heme b) binding site [chemical binding]; other site 1114958011229 Putative water exit pathway; other site 1114958011230 Binuclear center (heme o3/CuB) [ion binding]; other site 1114958011231 K-pathway; other site 1114958011232 Putative proton exit pathway; other site 1114958011233 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1114958011234 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1114958011235 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1114958011236 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1114958011237 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1114958011238 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1114958011239 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1114958011240 Predicted membrane protein [Function unknown]; Region: COG2246 1114958011241 GtrA-like protein; Region: GtrA; pfam04138 1114958011242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958011243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958011244 Anti-repressor SinI; Region: SinI; pfam08671 1114958011245 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1114958011246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958011247 S-adenosylmethionine binding site [chemical binding]; other site 1114958011248 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1114958011249 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1114958011250 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1114958011251 catalytic residues [active] 1114958011252 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1114958011253 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1114958011254 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1114958011255 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1114958011256 thiamine phosphate binding site [chemical binding]; other site 1114958011257 active site 1114958011258 pyrophosphate binding site [ion binding]; other site 1114958011259 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1114958011260 substrate binding site [chemical binding]; other site 1114958011261 multimerization interface [polypeptide binding]; other site 1114958011262 ATP binding site [chemical binding]; other site 1114958011263 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958011264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958011265 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1114958011266 putative dimerization interface [polypeptide binding]; other site 1114958011267 holin-like protein; Validated; Region: PRK01658 1114958011268 TIGR00659 family protein; Region: TIGR00659 1114958011269 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1114958011270 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1114958011271 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1114958011272 DNA binding residues [nucleotide binding] 1114958011273 dimer interface [polypeptide binding]; other site 1114958011274 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1114958011275 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1114958011276 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1114958011277 putative RNA binding site [nucleotide binding]; other site 1114958011278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958011279 S-adenosylmethionine binding site [chemical binding]; other site 1114958011280 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958011281 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1114958011282 active site 1114958011283 metal binding site [ion binding]; metal-binding site 1114958011284 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1114958011285 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1114958011286 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1114958011287 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1114958011288 active site 1114958011289 catalytic residues [active] 1114958011290 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1114958011291 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1114958011292 Ligand binding site; other site 1114958011293 metal-binding site 1114958011294 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1114958011295 synthetase active site [active] 1114958011296 NTP binding site [chemical binding]; other site 1114958011297 metal binding site [ion binding]; metal-binding site 1114958011298 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1114958011299 UbiA prenyltransferase family; Region: UbiA; pfam01040 1114958011300 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1114958011301 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1114958011302 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1114958011303 acyl-activating enzyme (AAE) consensus motif; other site 1114958011304 AMP binding site [chemical binding]; other site 1114958011305 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1114958011306 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1114958011307 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 1114958011308 DltD N-terminal region; Region: DltD_N; pfam04915 1114958011309 DltD central region; Region: DltD_M; pfam04918 1114958011310 DltD C-terminal region; Region: DltD_C; pfam04914 1114958011311 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1114958011312 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1114958011313 homodimer interface [polypeptide binding]; other site 1114958011314 substrate-cofactor binding pocket; other site 1114958011315 catalytic residue [active] 1114958011316 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1114958011317 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1114958011318 NAD binding site [chemical binding]; other site 1114958011319 sugar binding site [chemical binding]; other site 1114958011320 divalent metal binding site [ion binding]; other site 1114958011321 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114958011322 dimer interface [polypeptide binding]; other site 1114958011323 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1114958011324 methionine cluster; other site 1114958011325 active site 1114958011326 phosphorylation site [posttranslational modification] 1114958011327 metal binding site [ion binding]; metal-binding site 1114958011328 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1114958011329 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1114958011330 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1114958011331 active site 1114958011332 P-loop; other site 1114958011333 phosphorylation site [posttranslational modification] 1114958011334 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1114958011335 HTH domain; Region: HTH_11; pfam08279 1114958011336 Mga helix-turn-helix domain; Region: Mga; pfam05043 1114958011337 PRD domain; Region: PRD; pfam00874 1114958011338 PRD domain; Region: PRD; pfam00874 1114958011339 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1114958011340 active site 1114958011341 P-loop; other site 1114958011342 phosphorylation site [posttranslational modification] 1114958011343 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1114958011344 active site 1114958011345 phosphorylation site [posttranslational modification] 1114958011346 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1114958011347 active site 1114958011348 DNA binding site [nucleotide binding] 1114958011349 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1114958011350 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958011351 ABC-ATPase subunit interface; other site 1114958011352 dimer interface [polypeptide binding]; other site 1114958011353 putative PBP binding regions; other site 1114958011354 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1114958011355 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1114958011356 ABC-ATPase subunit interface; other site 1114958011357 dimer interface [polypeptide binding]; other site 1114958011358 putative PBP binding regions; other site 1114958011359 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1114958011360 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1114958011361 intersubunit interface [polypeptide binding]; other site 1114958011362 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958011363 dimerization interface [polypeptide binding]; other site 1114958011364 putative DNA binding site [nucleotide binding]; other site 1114958011365 putative Zn2+ binding site [ion binding]; other site 1114958011366 arsenical pump membrane protein; Provisional; Region: PRK15445 1114958011367 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1114958011368 transmembrane helices; other site 1114958011369 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1114958011370 active site 1114958011371 P-loop; other site 1114958011372 phosphorylation site [posttranslational modification] 1114958011373 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1114958011374 active site 1114958011375 methionine cluster; other site 1114958011376 phosphorylation site [posttranslational modification] 1114958011377 metal binding site [ion binding]; metal-binding site 1114958011378 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1114958011379 PTS system, lactose/cellobiose family IIC component; Region: lacE; TIGR00410 1114958011380 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1114958011381 beta-galactosidase; Region: BGL; TIGR03356 1114958011382 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1114958011383 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1114958011384 nucleotide binding site [chemical binding]; other site 1114958011385 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1114958011386 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1114958011387 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1114958011388 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1114958011389 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1114958011390 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1114958011391 tetramer interface [polypeptide binding]; other site 1114958011392 heme binding pocket [chemical binding]; other site 1114958011393 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1114958011394 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1114958011395 active site 1114958011396 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1114958011397 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1114958011398 Na binding site [ion binding]; other site 1114958011399 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1114958011400 putative substrate binding site [chemical binding]; other site 1114958011401 putative ATP binding site [chemical binding]; other site 1114958011402 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1114958011403 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114958011404 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1114958011405 Walker A/P-loop; other site 1114958011406 ATP binding site [chemical binding]; other site 1114958011407 Q-loop/lid; other site 1114958011408 ABC transporter signature motif; other site 1114958011409 Walker B; other site 1114958011410 D-loop; other site 1114958011411 H-loop/switch region; other site 1114958011412 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1114958011413 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1114958011414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958011415 ATP binding site [chemical binding]; other site 1114958011416 Q-loop/lid; other site 1114958011417 ABC transporter signature motif; other site 1114958011418 Walker B; other site 1114958011419 D-loop; other site 1114958011420 H-loop/switch region; other site 1114958011421 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1114958011422 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1114958011423 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1114958011424 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1114958011425 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1114958011426 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1114958011427 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1114958011428 putative active site [active] 1114958011429 putative metal binding site [ion binding]; other site 1114958011430 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1114958011431 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1114958011432 Walker A/P-loop; other site 1114958011433 ATP binding site [chemical binding]; other site 1114958011434 Q-loop/lid; other site 1114958011435 ABC transporter signature motif; other site 1114958011436 Walker B; other site 1114958011437 D-loop; other site 1114958011438 H-loop/switch region; other site 1114958011439 TOBE domain; Region: TOBE; pfam03459 1114958011440 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1114958011441 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1114958011442 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958011443 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958011444 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1114958011445 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1114958011446 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1114958011447 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1114958011448 UDP-glucose 4-epimerase; Region: PLN02240 1114958011449 NAD binding site [chemical binding]; other site 1114958011450 homodimer interface [polypeptide binding]; other site 1114958011451 active site 1114958011452 substrate binding site [chemical binding]; other site 1114958011453 peptidase T; Region: peptidase-T; TIGR01882 1114958011454 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1114958011455 metal binding site [ion binding]; metal-binding site 1114958011456 dimer interface [polypeptide binding]; other site 1114958011457 Tubby C 2; Region: Tub_2; cl02043 1114958011458 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1114958011459 substrate binding site [chemical binding]; other site 1114958011460 THF binding site; other site 1114958011461 zinc-binding site [ion binding]; other site 1114958011462 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1114958011463 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1114958011464 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1114958011465 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1114958011466 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1114958011467 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1114958011468 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1114958011469 hydroperoxidase II; Provisional; Region: katE; PRK11249 1114958011470 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1114958011471 tetramer interface [polypeptide binding]; other site 1114958011472 heme binding pocket [chemical binding]; other site 1114958011473 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1114958011474 domain interactions; other site 1114958011475 citrate transporter, CitMHS family; Region: citMHS; TIGR00784 1114958011476 Citrate transporter; Region: CitMHS; pfam03600 1114958011477 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1114958011478 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1114958011479 active site 1114958011480 active site 1114958011481 catalytic residues [active] 1114958011482 PRD domain; Region: PRD; pfam00874 1114958011483 PRD domain; Region: PRD; pfam00874 1114958011484 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1114958011485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011486 putative substrate translocation pore; other site 1114958011487 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1114958011488 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1114958011489 ATP binding site [chemical binding]; other site 1114958011490 Mg++ binding site [ion binding]; other site 1114958011491 motif III; other site 1114958011492 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958011493 nucleotide binding region [chemical binding]; other site 1114958011494 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1114958011495 RNA binding site [nucleotide binding]; other site 1114958011496 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1114958011497 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 1114958011498 YxiJ-like protein; Region: YxiJ; pfam14176 1114958011499 RHS Repeat; Region: RHS_repeat; pfam05593 1114958011500 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1114958011501 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1114958011502 RHS Repeat; Region: RHS_repeat; pfam05593 1114958011503 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1114958011504 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1114958011505 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1114958011506 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1114958011507 Amb_all domain; Region: Amb_all; smart00656 1114958011508 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1114958011509 EamA-like transporter family; Region: EamA; pfam00892 1114958011510 EamA-like transporter family; Region: EamA; pfam00892 1114958011511 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1114958011512 Ligand Binding Site [chemical binding]; other site 1114958011513 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b; cd09180 1114958011514 PLD-like domain; Region: PLDc_2; pfam13091 1114958011515 putative homodimer interface [polypeptide binding]; other site 1114958011516 putative active site [active] 1114958011517 catalytic site [active] 1114958011518 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1114958011519 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1114958011520 ATP binding site [chemical binding]; other site 1114958011521 putative Mg++ binding site [ion binding]; other site 1114958011522 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1114958011523 nucleotide binding region [chemical binding]; other site 1114958011524 ATP-binding site [chemical binding]; other site 1114958011525 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1114958011526 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1114958011527 active site 1114958011528 8-oxo-dGMP binding site [chemical binding]; other site 1114958011529 nudix motif; other site 1114958011530 metal binding site [ion binding]; metal-binding site 1114958011531 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1114958011532 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1114958011533 substrate binding site [chemical binding]; other site 1114958011534 active site 1114958011535 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1114958011536 hexamer interface [polypeptide binding]; other site 1114958011537 RNA binding site [nucleotide binding]; other site 1114958011538 Histidine-zinc binding site [chemical binding]; other site 1114958011539 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1114958011540 active sites [active] 1114958011541 tetramer interface [polypeptide binding]; other site 1114958011542 urocanate hydratase; Provisional; Region: PRK05414 1114958011543 imidazolonepropionase; Validated; Region: PRK09356 1114958011544 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1114958011545 active site 1114958011546 Agmatinase-like family; Region: Agmatinase-like; cd09990 1114958011547 agmatinase; Region: agmatinase; TIGR01230 1114958011548 active site 1114958011549 oligomer interface [polypeptide binding]; other site 1114958011550 Mn binding site [ion binding]; other site 1114958011551 S-methylmethionine transporter; Provisional; Region: PRK11387 1114958011552 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1114958011553 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1114958011554 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1114958011555 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1114958011556 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1114958011557 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1114958011558 Nucleoside recognition; Region: Gate; pfam07670 1114958011559 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1114958011560 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1114958011561 intersubunit interface [polypeptide binding]; other site 1114958011562 active site 1114958011563 catalytic residue [active] 1114958011564 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1114958011565 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1114958011566 non-specific DNA interactions [nucleotide binding]; other site 1114958011567 DNA binding site [nucleotide binding] 1114958011568 sequence specific DNA binding site [nucleotide binding]; other site 1114958011569 putative cAMP binding site [chemical binding]; other site 1114958011570 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1114958011571 sugar phosphate phosphatase; Provisional; Region: PRK10513 1114958011572 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958011573 active site 1114958011574 motif I; other site 1114958011575 motif II; other site 1114958011576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1114958011577 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1114958011578 SlyX; Region: SlyX; cl01090 1114958011579 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1114958011580 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1114958011581 putative ligand binding residues [chemical binding]; other site 1114958011582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294 1114958011583 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1114958011584 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1114958011585 Walker A/P-loop; other site 1114958011586 ATP binding site [chemical binding]; other site 1114958011587 Q-loop/lid; other site 1114958011588 ABC transporter signature motif; other site 1114958011589 Walker B; other site 1114958011590 D-loop; other site 1114958011591 H-loop/switch region; other site 1114958011592 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958011593 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1114958011594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958011595 ATP binding site [chemical binding]; other site 1114958011596 Mg2+ binding site [ion binding]; other site 1114958011597 G-X-G motif; other site 1114958011598 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958011599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958011600 active site 1114958011601 phosphorylation site [posttranslational modification] 1114958011602 intermolecular recognition site; other site 1114958011603 dimerization interface [polypeptide binding]; other site 1114958011604 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958011605 DNA binding site [nucleotide binding] 1114958011606 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1114958011607 intersubunit interface [polypeptide binding]; other site 1114958011608 active site 1114958011609 zinc binding site [ion binding]; other site 1114958011610 Na+ binding site [ion binding]; other site 1114958011611 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114958011612 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114958011613 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114958011614 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1114958011615 DNA interaction; other site 1114958011616 Metal-binding active site; metal-binding site 1114958011617 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1114958011618 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1114958011619 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1114958011620 Glucuronate isomerase; Region: UxaC; cl00829 1114958011621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011622 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958011623 putative substrate translocation pore; other site 1114958011624 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1114958011625 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1114958011626 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1114958011627 PYR/PP interface [polypeptide binding]; other site 1114958011628 dimer interface [polypeptide binding]; other site 1114958011629 TPP binding site [chemical binding]; other site 1114958011630 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1114958011631 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1114958011632 TPP-binding site; other site 1114958011633 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1114958011634 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1114958011635 substrate binding site [chemical binding]; other site 1114958011636 ATP binding site [chemical binding]; other site 1114958011637 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1114958011638 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1114958011639 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1114958011640 tetrameric interface [polypeptide binding]; other site 1114958011641 NAD binding site [chemical binding]; other site 1114958011642 catalytic residues [active] 1114958011643 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1114958011644 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1114958011645 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1114958011646 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958011647 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114958011648 active site 1114958011649 catalytic tetrad [active] 1114958011650 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1114958011651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011652 putative substrate translocation pore; other site 1114958011653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011654 heat shock protein 90; Provisional; Region: PRK05218 1114958011655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958011656 ATP binding site [chemical binding]; other site 1114958011657 Mg2+ binding site [ion binding]; other site 1114958011658 G-X-G motif; other site 1114958011659 short chain dehydrogenase; Validated; Region: PRK08589 1114958011660 classical (c) SDRs; Region: SDR_c; cd05233 1114958011661 NAD(P) binding site [chemical binding]; other site 1114958011662 active site 1114958011663 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1114958011664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958011665 active site 1114958011666 phosphorylation site [posttranslational modification] 1114958011667 intermolecular recognition site; other site 1114958011668 dimerization interface [polypeptide binding]; other site 1114958011669 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1114958011670 DNA binding residues [nucleotide binding] 1114958011671 dimerization interface [polypeptide binding]; other site 1114958011672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1114958011673 Histidine kinase; Region: HisKA_3; pfam07730 1114958011674 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1114958011675 ATP binding site [chemical binding]; other site 1114958011676 Mg2+ binding site [ion binding]; other site 1114958011677 G-X-G motif; other site 1114958011678 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1114958011679 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1114958011680 putative di-iron ligands [ion binding]; other site 1114958011681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958011682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958011683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1114958011684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1114958011685 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114958011686 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1114958011687 NAD(P) binding site [chemical binding]; other site 1114958011688 catalytic residues [active] 1114958011689 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1114958011690 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1114958011691 Trp docking motif [polypeptide binding]; other site 1114958011692 active site 1114958011693 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958011694 putative DNA binding site [nucleotide binding]; other site 1114958011695 dimerization interface [polypeptide binding]; other site 1114958011696 putative Zn2+ binding site [ion binding]; other site 1114958011697 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1114958011698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011699 putative substrate translocation pore; other site 1114958011700 RDD family; Region: RDD; pfam06271 1114958011701 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958011702 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1114958011703 active site 1114958011704 metal binding site [ion binding]; metal-binding site 1114958011705 peroxiredoxin; Region: AhpC; TIGR03137 1114958011706 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1114958011707 dimer interface [polypeptide binding]; other site 1114958011708 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1114958011709 catalytic triad [active] 1114958011710 peroxidatic and resolving cysteines [active] 1114958011711 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1114958011712 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1114958011713 catalytic residue [active] 1114958011714 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1114958011715 catalytic residues [active] 1114958011716 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1114958011717 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1114958011718 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1114958011719 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1114958011720 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1114958011721 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1114958011722 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1114958011723 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1114958011724 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1114958011725 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1114958011726 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1114958011727 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1114958011728 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1114958011729 Ligand binding site; other site 1114958011730 metal-binding site 1114958011731 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1114958011732 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1114958011733 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1114958011734 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1114958011735 AAA domain; Region: AAA_31; pfam13614 1114958011736 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114958011737 P-loop; other site 1114958011738 Magnesium ion binding site [ion binding]; other site 1114958011739 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114958011740 Magnesium ion binding site [ion binding]; other site 1114958011741 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1114958011742 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 1114958011743 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1114958011744 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 1114958011745 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1114958011746 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1114958011747 active site 1114958011748 catalytic tetrad [active] 1114958011749 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114958011750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958011751 Coenzyme A binding pocket [chemical binding]; other site 1114958011752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1114958011753 binding surface 1114958011754 TPR motif; other site 1114958011755 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958011756 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1114958011757 Arginase family; Region: Arginase; cd09989 1114958011758 agmatinase; Region: agmatinase; TIGR01230 1114958011759 active site 1114958011760 Mn binding site [ion binding]; other site 1114958011761 oligomer interface [polypeptide binding]; other site 1114958011762 S-methylmethionine transporter; Provisional; Region: PRK11387 1114958011763 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1114958011764 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1114958011765 inhibitor-cofactor binding pocket; inhibition site 1114958011766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958011767 catalytic residue [active] 1114958011768 PAS domain; Region: PAS_9; pfam13426 1114958011769 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1114958011770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1114958011771 Walker A motif; other site 1114958011772 ATP binding site [chemical binding]; other site 1114958011773 Walker B motif; other site 1114958011774 arginine finger; other site 1114958011775 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1114958011776 Cupin-like domain; Region: Cupin_8; pfam13621 1114958011777 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1114958011778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1114958011779 Walker A/P-loop; other site 1114958011780 ATP binding site [chemical binding]; other site 1114958011781 Q-loop/lid; other site 1114958011782 ABC transporter signature motif; other site 1114958011783 Walker B; other site 1114958011784 D-loop; other site 1114958011785 H-loop/switch region; other site 1114958011786 ABC transporter; Region: ABC_tran_2; pfam12848 1114958011787 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1114958011788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011789 putative substrate translocation pore; other site 1114958011790 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1114958011791 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1114958011792 hypothetical protein; Provisional; Region: PRK08328 1114958011793 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1114958011794 ATP binding site [chemical binding]; other site 1114958011795 substrate interface [chemical binding]; other site 1114958011796 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1114958011797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958011798 dimerization interface [polypeptide binding]; other site 1114958011799 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958011800 dimer interface [polypeptide binding]; other site 1114958011801 phosphorylation site [posttranslational modification] 1114958011802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958011803 ATP binding site [chemical binding]; other site 1114958011804 Mg2+ binding site [ion binding]; other site 1114958011805 G-X-G motif; other site 1114958011806 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1114958011807 DNA binding site [nucleotide binding] 1114958011808 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1114958011809 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1114958011810 protein binding site [polypeptide binding]; other site 1114958011811 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1114958011812 YycH protein; Region: YycI; cl02015 1114958011813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1114958011814 YycH protein; Region: YycH; pfam07435 1114958011815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1114958011816 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1114958011817 dimerization interface [polypeptide binding]; other site 1114958011818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1114958011819 putative active site [active] 1114958011820 heme pocket [chemical binding]; other site 1114958011821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1114958011822 dimer interface [polypeptide binding]; other site 1114958011823 phosphorylation site [posttranslational modification] 1114958011824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1114958011825 ATP binding site [chemical binding]; other site 1114958011826 Mg2+ binding site [ion binding]; other site 1114958011827 G-X-G motif; other site 1114958011828 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1114958011829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1114958011830 active site 1114958011831 phosphorylation site [posttranslational modification] 1114958011832 intermolecular recognition site; other site 1114958011833 dimerization interface [polypeptide binding]; other site 1114958011834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1114958011835 DNA binding site [nucleotide binding] 1114958011836 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1114958011837 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1114958011838 GDP-binding site [chemical binding]; other site 1114958011839 ACT binding site; other site 1114958011840 IMP binding site; other site 1114958011841 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958011842 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1114958011843 active site 1114958011844 replicative DNA helicase; Provisional; Region: PRK05748 1114958011845 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1114958011846 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1114958011847 Walker A motif; other site 1114958011848 ATP binding site [chemical binding]; other site 1114958011849 Walker B motif; other site 1114958011850 DNA binding loops [nucleotide binding] 1114958011851 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1114958011852 YycC-like protein; Region: YycC; pfam14174 1114958011853 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114958011854 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1114958011855 Phosphotransferase enzyme family; Region: APH; pfam01636 1114958011856 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1114958011857 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1114958011858 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1114958011859 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1114958011860 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1114958011861 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1114958011862 active site 1114958011863 substrate binding site [chemical binding]; other site 1114958011864 ATP binding site [chemical binding]; other site 1114958011865 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1114958011866 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1114958011867 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1114958011868 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1114958011869 diguanylate cyclase; Region: GGDEF; smart00267 1114958011870 DHH family; Region: DHH; pfam01368 1114958011871 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 1114958011872 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1114958011873 Predicted transcriptional regulators [Transcription]; Region: COG1733 1114958011874 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1114958011875 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1114958011876 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1114958011877 DHHA2 domain; Region: DHHA2; pfam02833 1114958011878 EamA-like transporter family; Region: EamA; pfam00892 1114958011879 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114958011880 EamA-like transporter family; Region: EamA; pfam00892 1114958011881 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1114958011882 active site 1114958011883 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1114958011884 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1114958011885 substrate binding [chemical binding]; other site 1114958011886 active site 1114958011887 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1114958011888 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1114958011889 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958011890 DNA-binding site [nucleotide binding]; DNA binding site 1114958011891 FCD domain; Region: FCD; pfam07729 1114958011892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1114958011893 H+ Antiporter protein; Region: 2A0121; TIGR00900 1114958011894 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1114958011895 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1114958011896 dimer interface [polypeptide binding]; other site 1114958011897 FMN binding site [chemical binding]; other site 1114958011898 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958011899 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1114958011900 putative DNA binding site [nucleotide binding]; other site 1114958011901 putative Zn2+ binding site [ion binding]; other site 1114958011902 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1114958011903 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1114958011904 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1114958011905 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1114958011906 MarR family; Region: MarR; pfam01047 1114958011907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1114958011908 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1114958011909 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1114958011910 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1114958011911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1114958011912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1114958011913 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1114958011914 putative dimerization interface [polypeptide binding]; other site 1114958011915 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1114958011916 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1114958011917 NAD(P) binding site [chemical binding]; other site 1114958011918 active site 1114958011919 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1114958011920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1114958011921 DNA-binding site [nucleotide binding]; DNA binding site 1114958011922 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1114958011923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1114958011924 homodimer interface [polypeptide binding]; other site 1114958011925 catalytic residue [active] 1114958011926 EamA-like transporter family; Region: EamA; pfam00892 1114958011927 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1114958011928 EamA-like transporter family; Region: EamA; pfam00892 1114958011929 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1114958011930 Predicted transcriptional regulator [Transcription]; Region: COG1959 1114958011931 Transcriptional regulator; Region: Rrf2; pfam02082 1114958011932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1114958011933 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1114958011934 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1114958011935 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114958011936 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1114958011937 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1114958011938 DNA binding residues [nucleotide binding] 1114958011939 drug binding residues [chemical binding]; other site 1114958011940 dimer interface [polypeptide binding]; other site 1114958011941 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 1114958011942 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1114958011943 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1114958011944 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1114958011945 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1114958011946 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1114958011947 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1114958011948 CAAX protease self-immunity; Region: Abi; pfam02517 1114958011949 benzoate transport; Region: 2A0115; TIGR00895 1114958011950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011951 putative substrate translocation pore; other site 1114958011952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1114958011953 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1114958011954 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1114958011955 putative metal binding site [ion binding]; other site 1114958011956 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1114958011957 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1114958011958 DNA binding site [nucleotide binding] 1114958011959 domain linker motif; other site 1114958011960 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1114958011961 putative dimerization interface [polypeptide binding]; other site 1114958011962 putative ligand binding site [chemical binding]; other site 1114958011963 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1114958011964 active site 1114958011965 putative catalytic site [active] 1114958011966 DNA binding site [nucleotide binding] 1114958011967 putative phosphate binding site [ion binding]; other site 1114958011968 metal binding site A [ion binding]; metal-binding site 1114958011969 AP binding site [nucleotide binding]; other site 1114958011970 metal binding site B [ion binding]; metal-binding site 1114958011971 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1114958011972 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1114958011973 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1114958011974 DNA binding site [nucleotide binding] 1114958011975 active site 1114958011976 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1114958011977 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1114958011978 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958011979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1114958011980 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1114958011981 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1114958011982 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1114958011983 dimer interface [polypeptide binding]; other site 1114958011984 ssDNA binding site [nucleotide binding]; other site 1114958011985 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1114958011986 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1114958011987 GTP-binding protein YchF; Reviewed; Region: PRK09601 1114958011988 YchF GTPase; Region: YchF; cd01900 1114958011989 G1 box; other site 1114958011990 GTP/Mg2+ binding site [chemical binding]; other site 1114958011991 Switch I region; other site 1114958011992 G2 box; other site 1114958011993 Switch II region; other site 1114958011994 G3 box; other site 1114958011995 G4 box; other site 1114958011996 G5 box; other site 1114958011997 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1114958011998 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1114958011999 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1114958012000 putative [4Fe-4S] binding site [ion binding]; other site 1114958012001 putative molybdopterin cofactor binding site [chemical binding]; other site 1114958012002 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1114958012003 molybdopterin cofactor binding site; other site 1114958012004 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1114958012005 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1114958012006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1114958012007 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1114958012008 Coenzyme A binding pocket [chemical binding]; other site 1114958012009 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 1114958012010 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1114958012011 ParB-like nuclease domain; Region: ParB; smart00470 1114958012012 KorB domain; Region: KorB; pfam08535 1114958012013 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1114958012014 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114958012015 P-loop; other site 1114958012016 Magnesium ion binding site [ion binding]; other site 1114958012017 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1114958012018 Magnesium ion binding site [ion binding]; other site 1114958012019 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1114958012020 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1114958012021 ParB-like nuclease domain; Region: ParB; smart00470 1114958012022 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1114958012023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1114958012024 S-adenosylmethionine binding site [chemical binding]; other site 1114958012025 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1114958012026 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1114958012027 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1114958012028 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1114958012029 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1114958012030 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1114958012031 G1 box; other site 1114958012032 GTP/Mg2+ binding site [chemical binding]; other site 1114958012033 Switch I region; other site 1114958012034 G2 box; other site 1114958012035 Switch II region; other site 1114958012036 G3 box; other site 1114958012037 G4 box; other site 1114958012038 G5 box; other site 1114958012039 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1114958012040 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1114958012041 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1114958012042 G-X-X-G motif; other site 1114958012043 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1114958012044 RxxxH motif; other site 1114958012045 OxaA-like protein precursor; Validated; Region: PRK02944 1114958012046 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1114958012047 ribonuclease P; Reviewed; Region: rnpA; PRK00499